Publications by authors named "R Custers"

85 Publications

A need for recalibrating access and benefit sharing: How best to improve conservation, sustainable use of biodiversity, and equitable benefit sharing in a mutually reinforcing manner?: How best to improve conservation, sustainable use of biodiversity, and equitable benefit sharing in a mutually reinforcing manner?

EMBO Rep 2021 Dec 20:e53973. Epub 2021 Dec 20.

Dominic Muyldermans BV, Oostkamp, Belgium.

The upcoming UN Biodiversity Conference should address shortfalls of Access and Benefit Sharing systems inspired by the Nagoya Protocol to help improve sustainable use of biodiversity and equitable benefit sharing.
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http://dx.doi.org/10.15252/embr.202153973DOI Listing
December 2021

Studying the sense of agency in the absence of motor movement: an investigation into temporal binding of tactile sensations and auditory effects.

Exp Brain Res 2021 Jun 7;239(6):1795-1806. Epub 2021 Apr 7.

Department of Psychology, Utrecht University, PO BOX 80140, 3508 TC, Utrecht, The Netherlands.

People form coherent representations of goal-directed actions. Such agency experiences of intentional action are reflected by a shift in temporal perception: self-generated motor movements and subsequent sensory effects are perceived to occur closer together in time-a phenomenon termed intentional binding. Building on recent research suggesting that temporal binding occurs without intentionally performing actions, we further examined whether such perceptual compression occurs when motor action is fully absent. In three experiments, we used a novel sensory-based adaptation of the Libet clock paradigm to assess how a brief tactile sensation on the index finger and a resulting auditory stimulus perceptually bind together in time. Findings revealed robust temporal repulsion (instead of binding) between tactile sensation and auditory effect. Temporal repulsion was attenuated when participants could anticipate the identity and temporal onset (two crucial components of intentional action) of the tactile sensation. These findings are briefly discussed in the context of differences between intentional movement and anticipated bodily sensations in shaping action coherence and agentic experiences.
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http://dx.doi.org/10.1007/s00221-021-06087-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277642PMC
June 2021

Five-Year Outcome of 1-Stage Cell-Based Cartilage Repair Using Recycled Autologous Chondrons and Allogenic Mesenchymal Stromal Cells: A First-in-Human Clinical Trial.

Am J Sports Med 2021 03 16;49(4):941-947. Epub 2021 Feb 16.

Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Long-term clinical evaluation of patient outcomes can steer treatment choices and further research for cartilage repair. Using mesenchymal stromal cells (MSCs) as signaling cells instead of stem cells is a novel approach in the field.

Purpose: To report the 5-year follow-up of safety, clinical efficacy, and durability after treatment of symptomatic cartilage defects in the knee with allogenic MSCs mixed with recycled autologous chondrons in first-in-human study of 1-stage cartilage repair.

Study Design: Case series; Level of evidence, 4.

Methods: This study is an investigator-driven study aiming at the feasibility and safety of this innovative cartilage repair procedure. Between 2013 and 2014, a total of 35 patients (mean ± SD age, 36 ± 8 years) were treated with a 1-stage cartilage repair procedure called IMPACT (Instant MSC Product Accompanying Autologous Chondron Transplantation) for a symptomatic cartilage defect on the femoral condyle or trochlear groove. Subsequent follow-up after initial publication was performed annually using online patient-reported outcome measures with a mean follow-up of 61 months (range, 56-71 months). Patient-reported outcome measures included the KOOS (Knee injury and Osteoarthritis Outcome Score), visual analog scale for pain, and EuroQol-5 Dimensions. All clinical data and serious adverse events, including additional treatment received after IMPACT, were recorded. A failure of IMPACT was defined as a chondral defect of at least 20% of the index lesion with a need for a reintervention including a surgical procedure or an intra-articular injection.

Results: Using allogenic MSCs, no signs of a foreign body response or serious adverse reactions were recorded after 5 years. The majority of patients showed statistically significant and clinically relevant improvement in the KOOS and all its subscales from baseline to 60 months: overall, 57.9 ± 16.3 to 78.9 ± 17.7 ( < .001); Pain, 62.3 ± 18.9 to 79.9 ± 20.0 ( = .03); Function, 61.6 ± 16.5 to 79.4 ± 17.3 ( = .01); Activities of Daily Living, 69.0 ± 19.0 to 89.9 ± 14.9 ( < .001); Sports and Recreation, 32.3 ± 22.6 to 57.5 ± 30.0 ( = .02); and Quality of Life, 25.9 ± 12.9 to 55.8 ± 26.8 ( < .001). The visual analog scale score for pain improved significantly from baseline (45.3 ± 23.6) to 60 months (15.4 ± 13.4) ( < .001). Five cases required reintervention.

Conclusion: This is the first study showing the midterm safety and efficacy of the proof of concept that allogenic MSCs augment 1-stage articular cartilage repair. The absence of serious adverse events and the clinical outcome support the longevity of this unique concept. These data support MSC-augmented chondron transplantation (IMPACT) as a safe 1-stage surgical solution that is considerably more cost-effective and a logistically advantageous alternative to conventional 2-stage cell-based therapy for articular chondral defects in the knee.
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http://dx.doi.org/10.1177/0363546520988069DOI Listing
March 2021

Intentional action and limitation of personal autonomy. Do restrictions of action selection decrease the sense of agency?

Conscious Cogn 2021 02 20;88:103076. Epub 2021 Jan 20.

Department of Psychology, Utrecht University, The Netherlands. Electronic address:

The experience of being an intentional agent is a key component of personal autonomy. Here, we tested how undermining intentional action affects the sense of agency as indexed by intentional binding. In three experiments using the Libet clock paradigm, participants judged the onset of their action (key presses) and resulting effect (auditory stimuli) under conditions of no, partial, or full autonomy over selecting and timing their actions. In all cases, we observed a moderate to strong intentional binding effect. However, we found no evidence for an influence of personal autonomy on intentional binding. These findings thus suggest that being unable to decide how and when to perform actions does not affect the perceived temporal binding between action and effect, a phenomenon suggested to be associated with the implicit sense of agency. We discuss the implications of our findings in the context of research on personal autonomy and goal-directed behavior.
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http://dx.doi.org/10.1016/j.concog.2021.103076DOI Listing
February 2021

Discussions on the quality of antibodies are no reason to ban animal immunization.

EMBO Rep 2020 12 12;21(12):e51761. Epub 2020 Nov 12.

Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Debates about the source of antibodies and their use are confusing two different issues. A ban on life immunization would have no repercussions on the quality of antibodies.
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http://dx.doi.org/10.15252/embr.202051761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726777PMC
December 2020
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