Publications by authors named "Quinn Lu"

29Publications

Comparative Analysis of Multiple Immunoassays for Cytokine Profiling in Drug Discovery.

Authors:

Michael Platchek Quinn Lu Hoang Tran Wensheng Xie

SLAS Discov 2020 Dec 13;25(10):1197-1213. Epub 2020 Sep 13.

Novel Human Genetics Research Unit, GlaxoSmithKline, Collegeville, PA, USA.

View Article and Find Full Text PDF

December 2020

Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

Authors:

Xin Zeng Robert Kirkpatrick Glenn Hofmann Didier Grillot Valerie Linhart Fabrice Viviani Joseph Marino Joseph Boyer Taylor L Graham Quinn Lu Zining Wu Andrew Benowitz Rick Cousins

PLoS One 2018 12;13(12):e0207140. Epub 2018 Dec 12.

R&D Alternative Discovery and Development, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

View Article and Find Full Text PDF

April 2019

Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments.

Authors:

Michelle L Kimberland Wangfang Hou Adolfo Alfonso-Pecchio Stephen Wilson Yanhua Rao Shu Zhang Quinn Lu

J Biotechnol 2018 Oct 22;284:91-101. Epub 2018 Aug 22.

Target Sciences, GlaxoSmithKline R&D, 1250 South Collegeville Road, Collegeville, PA 19426, USA. Electronic address:

View Article and Find Full Text PDF

October 2018

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Authors:

Carl A Machutta Christopher S Kollmann Kenneth E Lind Xiaopeng Bai Pan F Chan Jianzhong Huang Lluis Ballell Svetlana Belyanskaya Gurdyal S Besra David Barros-Aguirre Robert H Bates Paolo A Centrella Sandy S Chang Jing Chai Anthony E Choudhry Aaron Coffin Christopher P Davie Hongfeng Deng Jianghe Deng Yun Ding Jason W Dodson David T Fosbenner Enoch N Gao Taylor L Graham Todd L Graybill Karen Ingraham Walter P Johnson Bryan W King Christopher R Kwiatkowski Joël Lelièvre Yue Li Xiaorong Liu Quinn Lu Ruth Lehr Alfonso Mendoza-Losana John Martin Lynn McCloskey Patti McCormick Heather P O'Keefe Thomas O'Keeffe Christina Pao Christopher B Phelps Hongwei Qi Keith Rafferty Genaro S Scavello Matt S Steiginga Flora S Sundersingh Sharon M Sweitzer Lawrence M Szewczuk Amy Taylor May Fern Toh Juan Wang Minghui Wang Devan J Wilkins Bing Xia Gang Yao Jean Zhang Jingye Zhou Christine P Donahue Jeffrey A Messer David Holmes Christopher C Arico-Muendel Andrew J Pope Jeffrey W Gross Ghotas Evindar

Nat Commun 2018 07 13;9:16227. Epub 2018 Jul 13.

View Article and Find Full Text PDF

July 2018

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Authors:

Carl A Machutta Christopher S Kollmann Kenneth E Lind Xiaopeng Bai Pan F Chan Jianzhong Huang Lluis Ballell Svetlana Belyanskaya Gurdyal S Besra David Barros-Aguirre Robert H Bates Paolo A Centrella Sandy S Chang Jing Chai Anthony E Choudhry Aaron Coffin Christopher P Davie Hongfeng Deng Jianghe Deng Yun Ding Jason W Dodson David T Fosbenner Enoch N Gao Taylor L Graham Todd L Graybill Karen Ingraham Walter P Johnson Bryan W King Christopher R Kwiatkowski Joël Lelièvre Yue Li Xiaorong Liu Quinn Lu Ruth Lehr Alfonso Mendoza-Losana John Martin Lynn McCloskey Patti McCormick Heather P O'Keefe Thomas O'Keeffe Christina Pao Christopher B Phelps Hongwei Qi Keith Rafferty Genaro S Scavello Matt S Steiginga Flora S Sundersingh Sharon M Sweitzer Lawrence M Szewczuk Amy Taylor May Fern Toh Juan Wang Minghui Wang Devan J Wilkins Bing Xia Gang Yao Jean Zhang Jingye Zhou Christine P Donahue Jeffrey A Messer David Holmes Christopher C Arico-Muendel Andrew J Pope Jeffrey W Gross Ghotas Evindar

Nat Commun 2017 07 17;8:16081. Epub 2017 Jul 17.

GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA.

View Article and Find Full Text PDF

July 2017

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.

J Am Heart Assoc 2017 May 9;6(5). Epub 2017 May 9.

Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area GlaxoSmithKline, King of Prussia, PA.

View Article and Find Full Text PDF

May 2017

Applications of CRISPR genome editing technology in drug target identification and validation.

Authors:

Quinn Lu George P Livi Sundip Modha Kosuke Yusa Ricardo Macarrón David J Dow

Expert Opin Drug Discov 2017 Jun 23;12(6):541-552. Epub 2017 Apr 23.

b Target Sciences, GlaxoSmithKline R&D , Stevenage , UK.

View Article and Find Full Text PDF

June 2017

A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.

Authors:

Wensheng Xie Robert Silvers Michael Ouellette Zining Wu Quinn Lu Hu Li Kathleen Gallagher Kathy Johnson Monica Montoute

Methods Mol Biol 2016 ;1439:207-26

Department of Biological Sciences, Platform Technology and Science, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, USA.

View Article and Find Full Text PDF

December 2017

Gene Expression in Mammalian Cells Using BacMam, a Modified Baculovirus System.

Authors:

James A Fornwald Quinn Lu Frederick M Boyce Robert S Ames

Methods Mol Biol 2016 ;1350:95-116

Platform Technology and Science, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA, 19426, USA.

View Article and Find Full Text PDF

October 2016

A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance.

Authors:

Xin Zeng Monica Montoute Tiger W Bee Hong Lin Lorena A Kallal Yan Liu Pankaj Agarwal Dayuan Wang Quinn Lu Dwight Morrow Andrew J Pope Zining Wu

J Biomol Screen 2016 Mar 9;21(3):260-8. Epub 2015 Dec 9.

R&D Platform Technology Sciences, GlaxoSmithKine, Upper Providence, Collegeville, PA, USA.

View Article and Find Full Text PDF

March 2016

Co-expression for intracellular processing in microbial protein production.

Authors:

Quinn Lu Juan C Aon

Biotechnol Lett 2014 Mar 16;36(3):427-41. Epub 2013 Oct 16.

Department of Biological Reagents & Assay Development, Platform Technology & Science, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA,

View Article and Find Full Text PDF

March 2014

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Authors:

Basil P Hubbard Christine Loh Ana P Gomes Jun Li Quinn Lu Taylor Lg Doyle Jeremy S Disch Sean M Armour James L Ellis George P Vlasuk David A Sinclair

Cell Cycle 2013 Jul;12(14):2233-40

Department of Genetics, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF

July 2013

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

Bioorg Med Chem Lett 2013 Jun 16;23(12):3584-8. Epub 2013 Apr 16.

Department of Chemistry, Heart Failure Disease Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.

View Article and Find Full Text PDF

June 2013

Development of a cell-based high throughput luciferase enzyme fragment complementation assay to identify nuclear-factor-e2-related transcription factor 2 activators.

Authors:

Wensheng Xie Christina Pao Taylor Graham Ed Dul Quinn Lu Thomas D Sweitzer Robert S Ames Hu Li

Assay Drug Dev Technol 2012 Dec 10;10(6):514-24. Epub 2012 May 10.

Department of Biological Reagents and Assay Development, Platform Technology and Science, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.

View Article and Find Full Text PDF

December 2012

Perspectives on the discovery of small-molecule modulators for epigenetic processes.

Authors:

Quinn Lu Amy M Quinn Mehul P Patel Simon F Semus Alan P Graves Deepak Bandyopadhyay Andrew J Pope Sara H Thrall

J Biomol Screen 2012 Jun 5;17(5):555-71. Epub 2012 Mar 5.

GlaxoSmithKline, Collegeville, Pennsylvania, USA.

View Article and Find Full Text PDF

June 2012

Production of protein complexes via co-expression.

Authors:

John J Kerrigan Qing Xie Robert S Ames Quinn Lu

Protein Expr Purif 2011 Jan 6;75(1):1-14. Epub 2010 Aug 6.

Biological Reagents & Assay Development, Platform Technology & Science, GlaxoSmithKline R&D, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

View Article and Find Full Text PDF

January 2011

Development of a high throughput cell-based assay for soluble epoxide hydrolase using BacMam technology.

Authors:

Wensheng Xie Xiaoyan Tang Quinn Lu Robert S Ames Steven J Ratcliffe Hu Li

Mol Biotechnol 2010 Jul;45(3):207-17

Biological Reagents and Assay Development, Molecular Discovery Research, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426, USA.

View Article and Find Full Text PDF

July 2010

Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

Authors:

Cynthia M Rominger Wei-Lin Tiger Bee Robert A Copeland Elizabeth A Davenport Aidan Gilmartin Richard Gontarek Keith R Hornberger Lorena A Kallal Zhihong Lai Kenneth Lawrie Quinn Lu Lynette McMillan Maggie Truong Peter J Tummino Brandon Turunen Matthew Will William J Zuercher David H Rominger

J Pharmacol Exp Ther 2009 Jun 20;329(3):995-1005. Epub 2009 Mar 20.

Oncology Center for Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania, USA.

View Article and Find Full Text PDF

June 2009

Optimized procedures for producing biologically active chemokines.

Authors:

Quinn Lu Matthew C Burns Patrick J McDevitt Taylor L Graham Abby J Sukman James A Fornwald Xiaoyan Tang Kathleen T Gallagher Gerald E Hunsberger James J Foley Dulcie B Schmidt John J Kerrigan Tia S Lewis Robert S Ames Kyung O Johanson

Protein Expr Purif 2009 Jun;65(2):251-60

GlaxoSmithKline, Biological Reagents & Assay Development, Mail Code: UE0548, 709 Swedeland Road, King of Prussia, PA 19406, USA.

View Article and Find Full Text PDF

June 2009

Viral-mediated gene delivery for cell-based assays in drug discovery.

Authors:

Robert S Ames Quinn Lu

Expert Opin Drug Discov 2009 Mar;4(3):243-56

Molecular Discovery Research, GlaxoSmithKline R&D, UE0433, 709 Swedeland Road, King of Prussia, PA 19406, USA +1 610 270 7602 ; +1 610 270 7359 ;

View Article and Find Full Text PDF

March 2009