Publications by authors named "Quanhai Wang"

9 Publications

  • Page 1 of 1

Fusion proteins of biologic agents in the treatment of rheumatoid arthritis (RA): A network meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26350

Department of Epidemiology and Biostatistics.

Background: To evaluate the efficacy of fusion proteins biologics (Etanercept (ETN), Anakinra (ANA), and Abatacept) combinations in the treatment of rheumatoid arthritis (RA) using network meta-analysis to rank those according to their performance medicines. The performance of these processes is ranked according to the results of the analysis and an explanatory study of the possible results is carried out.

Methods: Multiple databases including PubMed, EMBASE, and Cochrane Library were used to identify applicable articles and collect relevant data to analyze using STATA (14.0) software. The literature included in this study was divided into a combination of a placebo, methotrexate (MTX), and an observation group (1 of the 3 drugs). The last search date was December 12, 2019.

Results: A total of 19 eligible randomized controlled trials of fusion proteins biologics were identified, a total of 1109 papers were included, and the results showed that the ETN + MTX had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking curve of 91.6, was significantly superior (P < .05). Patients who had received ETN or ETN + MTX or ANA had effective compared with patients who had received placebo (95% CI 1.28%-8.47%; 1.92%-19.18%; 1.06%-10.45%).

Conclusions: 1. The combination of ETN and MTX had the highest probability of optimal treatment compared to other drugs and 2. ENT, ENT + MTX, and ANA were effective in the treatment of RA compared to placebo.
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http://dx.doi.org/10.1097/MD.0000000000026350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213327PMC
June 2021

Flammability and Propagation Dynamics of Planar Freely Propagating Dimethyl Ether Premixed Flame.

ACS Omega 2020 May 8;5(19):10965-10976. Epub 2020 May 8.

Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education of China, Chongqing 400044, China.

Flammability dynamics and physics play a crucial role in fire safety and combustion efficiency. This paper numerically studied the flammability dynamics of dimethyl ether/air freely propagating premixed flame over a broad range of equivalence ratios (ϕ). The results showed that the traditional flammability range should be redefined considering the impact of low-temperature chemistry. A physically stable warm-flame branch existed in the ultrarich region (ϕ = 7.58-12.59), which connected the hot and cool flame transition smoothly. However, in the lean region, the transition between hot and cool flames was completed by extinguishment or ignition. Sensitivity analysis was performed to reveal the governing chemical and diffusive processes for the flammability limits (FLs). In addition to the high-temperature reactions, low-temperature chemistry also played an important role in the lean hot-flame FL because of its double-flame structure. Heat conduction and fuel and oxygen diffusions were the most significant diffusive processes for the near-limit flame propagation. The near-limit flames had a diffusion-reaction structure, in which the flame front propagation was sustained by the heat conduction-induced ignition rather than the autoignition wave. The hot-flame extinction was induced by radiative extinguishment of the high-temperature propagating front embedded in the double-flame structure, and the cool-flame extinction was induced by excessive diffusive loss.
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http://dx.doi.org/10.1021/acsomega.0c00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241034PMC
May 2020

[Effect of hydrogen sulfide on tissue factor-induced disseminated intravascular coagulation in rabbits].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2015 Feb;27(2):92-6

Experimental Center for Function Subjects, Wannan Medical College, Wuhu 241002, Anhui, China. Corresponding author: Xu Lei, Email:

Objective: To investigate the protective effect of hydrogen sulfide (H2S) on tissue factor-induced disseminated intravascular coagulation (DIC) in rabbits and its mechanism.

Methods: Thirty-two healthy rabbits were randomly divided into four groups: normal control group, NaHS control group, DIC model group, NaHS pretreatment group (each, n = 8). Ten minutes before model reproduction, rabbits in NaHS control and pretreatment groups were given 3.4 mg/kg NaHS (dissolved in normal saline to 5 mL) via ear vein, while rabbits in normal control and DIC model groups were given an equivalent volume of normal saline. Ten minutes later, rabbits in DIC model and NaHS pretreatment groups were intravenously given tissue factor (TF) 2 mL/kg (dissolved in normal saline to 30 mL, at the speed of 1 mL/min for 5 minutes, 2 mL/min for 5 minutes, and 3 mL/min for 5 minutes), and rabbits in normal control and NaHS control groups were given normal saline. 3 mL of blood was collected 10 minutes before TF injection, and 3, 5, 8, 10, 13, 15, 45, 85, 135 minutes after TF injection for determination of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen content (FIB), fibrin degradation products (FDP), and platelet count (PLT). Microcirculation in the mesentery was also observed under microscope.

Results: Compared with normal control group, PT and APTT became shorter at 5 minutes after TF injection, and the rate of their change was increased [PT: -8.3 (-11.7 to -5.3)% vs. 1.3 (-2.5 to 3.8)%, P < 0.01; APTT: -19.1 (-30.4 to -9.4)% vs. -2.6 (-6.2 to 3.0)%, P < 0.05]. PT and APTT were prolonged 15 minutes after TF injection, and their changes were more significant [PT: 31.0 (25.0 to 36.9)% vs. -1.3 (-6.3 to 5.0)%, APTT: 61.3 (50.0 to 72.9)% vs. 0.0 (-10.0 to 10.0)%, both P < 0.01] in DIC model group. TT was gradually reduced after TF injection, FIB and PLT were gradually decreased, and their changes were more obvious at 15 minutes in DIC model group compared with those in normal control group [TT: -9.5 (-12.0 to -6.2)% vs. -2.0 (-4.0 to 0.7)%, FIB: -4.3 (-9.9 to -2.2)% vs. -1.0 (-5.8 to 4.3)%, PLT: -90.0 (-93.4 to -86.5)% vs. -1.0 (-3.9 to 2.6), all P < 0.01]. After TF injection, it appeared latex-like particles in FDP test board, and it was gradually increased within 3-15 minutes, and then it gradually became less marked. The rate of blood flow in mesenteric capillaries was decreased obviously within 10 minutes, and it became faster accompanying with obvious hemorrhage. PT and APTT in NaHS pretreatment group became shortened 5 minutes after TF injection, and their rate of change was significantly decreased compared with that of DIC model group [PT: -6.3 (-8.6 to 0.0)% vs. -8.3 (-11.7 to -5.3)%, APTT: -13.6 (-24.2 to -2.3)% vs. -19.1 (-30.4 to -9.4)%, both P < 0.05], and prolonged at 15 minutes, and their rate of change was significantly decreased compared with that of DIC model group [PT: 10.1 (3.8 to 15.2)% vs. 31.0 (25.0 to 36.9)%, P < 0.01; APTT: 27.8 (-15.8 to 39.7)% vs. 61.3 (50.0 to 72.9)%, P < 0.05]. TT, FIB, and PLT were reduced at 15 minutes in NaHS pretreatment group, and their rate of change was markedly decreased compared with that of DIC model group [TT: -4.5 (-7.8 to -1.3)% vs. -9.5 (-12.0 to -6.2)%, P < 0.01; FIB: -3.3 (-8.0 to 1.9)% vs. -4.3 (-9.9 to -2.2)%, P < 0.05; PLT: -58.8 (-53.0 to 64.0)% vs. -90.0 (-93.4 to -86.5)%, P < 0.01]. The rate of agglutination of latex particles in NaHS pretreatment group was decreased significantly at each time point compared with DIC model group; mesenteric capillary blood flow slowed down gradually within 10 minutes, but it was faster as compared with the DIC model group. It became faster later, but bleeding was obviously less.

Conclusions: These results show that H2S protects against TF-induced DIC by inhibiting the activity of coagulation system and platelet aggregation.
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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2015.02.003DOI Listing
February 2015

Recovery of SO and MgO from By-Products of MgO Wet Flue Gas Desulfurization.

Environ Eng Sci 2014 Nov;31(11):621-630

Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, Ministry of Education, Chongqing University , Chongqing, People's Republic of China .

An industrial demonstration unit using natural gas as a heat source was built to calcine the by-products of MgO wet flue gas desulfurization from power plants; influencing factors on the SO content in calciner gas were comprehensively analyzed; and an advantageous recycling condition of MgO and SO from by-products was summarized. Results showed that the SO content in the calciner gas was increased by more than 10 times under a lower excess air coefficient, a higher feed rate, a lower crystal water in by-products, and a higher feed port position. For the tests conducted under the excess air coefficient above and below one, the effect of the furnace temperature on the SO content in the calciner gas was reversed. Results of activity analysis indicate that particles of MgO generated under the calcination temperature of 900-1,000°C had a high activity. In contrast, due to the slight sintering, MgO generated under the calcination temperature of 1,100°C had a low activity. To recycle SO as well as MgO, a temperature range of 900-927°C for TE103 is proposed. These studies will prompt the desulfurization market diversification, reduce the sulfur's dependence on imports for making sulfuric acid, be meaningful to balance the usage of the natural resource in China, and be regarded as a reference for the development of this technology for other similar developing countries.
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http://dx.doi.org/10.1089/ees.2014.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215338PMC
November 2014

The role of social support on occupational stress among hospital nurses.

Int J Clin Exp Med 2014 15;7(9):3000-4. Epub 2014 Sep 15.

School of Public Health, Wannan Medical College Wuhu 241002, People's Republic of China.

Stress is a nonspecific reaction to everything the body needs. Although occupational stress exists in every occupation, it is seen with more frequency and intensity amongst those occupations related to human health. In this study, we aimed to investigate the relationship between occupational stress and social support (SS) among hospital nurses. A cross-sectional survey was conducted among 1144 hospital nurse in China. They were investigated with a self-administered questionnaire about socio-demographic characteristics, occupational stress and social support. A validated version of the revised Occupational Stress Inventory (OSI-R) was applied to evaluate occupational stress; SS was measured by nine questions. Logistic regression analysis was used to study the association between occupational stress and SS and adjusted for income, gender, marital status, working years, educational level, and profession. Of 1144 nurses, the majority age group was less than 30 years, and the mean age across participants was 31.8 years. Further correlation analysis indicated that score of ORQ and PSQ had a significant negative correlation with score of SS (P<0.05), and a significant positive correlation was found between Score of PRQ and score of SS (P<0.05). The univariate analysis and multivariate analysis results also revealed that high SS increased significantly with decreasing ORQ score and increasing PRQ score after controlling for income, gender, marital status, working years, educational level and job title. SS significantly influences occupational stress in hospitals nurse. We also should pay more attention to occupational stress of married and long working years nurse.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211824PMC
October 2014

[Factors affecting the quality of life of elderly diabetic patients: survey in north and south Wanjiang river regions].

Nan Fang Yi Ke Da Xue Xue Bao 2014 Feb;34(2):283-5

Department of Epidemiology and Statistics, School of Public Health, Wannan Medical College, Wuhu 241002, China.E-mail:

Objective: To investigate the quality of life of elderly diabetic patients and its influencing factors.

Methods: By randomized cluster sampling, we conducted a survey in 1450 elderly residents (over 60 years old) living in urban, suburban and rural areas in south and north Anhui province. We evaluated the quality of life of the elderly diabetic patients using a demographic information questionnaire and full items on Short Form (36) Health Survey (SF-36).

Results: The elderly diabetic patients had lower scores in all dimensions of quality of life than the elderly without diabetes. Multiple linear regression analysis showed a linear regression in the quality of life among the elderly diabetic patients in terms of geographic regions, education, personality, sleep quality, and age.

Conclusion: Elderly diabetic patients have generally poor quality of life, which was subjected to the influences by geographic regions, education, personality, sleep quality, and age, suggesting the necessity of corresponding interventions to improve the quality of life of these patients.
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February 2014

Serum calcium levels are not associated with coronary heart disease.

Vasc Health Risk Manag 2013 3;9:517-20. Epub 2013 Sep 3.

Department of Preventive Medicine, Wannan Medical College, Wuhu, People's Republic of China.

Background: Numerous studies have reported that low calcium intake is related to a higher prevalence of cardiovascular disease. However, the relationship between serum calcium and coronary heart disease is unclear. The purpose of this study was to compare serum calcium levels in patients with coronary heart disease and those in healthy individuals.

Methods: This retrospective, case-control study conducted in the People's Republic of China comprised 380 cases and 379 controls. Serum calcium levels, blood lipids, and anthropometric measurements were measured in both groups. The Student's unpaired t-test or Chi-square test was used to compare differences between cases and controls. Pearson's partial correlation coefficient was used to determine the association between serum calcium, blood lipids, and blood pressure in both groups.

Results: Our results indicate that the average level of serum calcium in cases was higher than in controls. Serum calcium levels showed no correlation with any parameter except for triglycerides in either group.

Conclusion: Overall, these data suggest that serum calcium has no influence on coronary heart disease or triglyceride levels in the general population.
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http://dx.doi.org/10.2147/VHRM.S49136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772709PMC
March 2014

The relationship between serum calcium level, blood lipids, and blood pressure in hypertensive and normotensive subjects who come from a normal university in east of China.

Biol Trace Elem Res 2013 Jun 29;153(1-3):35-40. Epub 2013 Mar 29.

Department of Preventive Medicine, Wannan Medical College, No. 22 Road West Wenchang, Yijiang District, Wuhu 241002, People's Republic of China.

Previous studies revealed that low calcium intake is related to high prevalence of cardiovascular diseases such as hypertension. However, the relationship between serum calcium and blood pressure was unclear. The prevalence of hypertension is high in China. Thus, the aim of this study was to evaluate the serum calcium level between hypertensive and normotensive groups and to investigate the correlation between serum calcium, blood pressure, and blood lipid parameters. A total of 1,135 adult subjects participated in this study and were divide into two study groups: a hypertensive group (n = 316) who had 140 mmHg or higher in systolic blood pressure (SBP) or 90 mmHg or higher in diastolic blood pressure (DBP) and an age- and sex-matched normotensive group (n = 819, 120 mmHg or less SBP and 80 mmHg or less DBP). Our results indicate a significant trend for men (60 years old or older) in the direction of decreasing blood pressure with increasing serum calcium level, but no trend for women was indicated. In the normotensive group, a significant positive correlation was found between DBP and total cholesterol (P < 0.01) and triglyceride (P < 0.01), Likewise, triglyceride was positively correlated with SBP (P < 0.01). Overall, these data suggest that serum calcium may have an influence in the blood pressure of older male subjects with hypertension and in blood lipid profiles of normotensive subjects.
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http://dx.doi.org/10.1007/s12011-013-9646-3DOI Listing
June 2013

Impacts of halogen additions on mercury oxidation, in a slipstream selective catalyst reduction (SCR), reactor when burning sub-bituminous coal.

Environ Sci Technol 2008 Jan;42(1):256-61

Institute for Combustion Science and Environmental Technology, Western Kentucky University, Bowling Green, Kentucky 42101, USA.

This paper presents a comparison of impacts of halogen species on the elemental mercury (Hg(0)) oxidation in a real coal-derived flue gas atmosphere. It is reported there is a higher percentage of Hg(0) in the flue gas when burning sub-bituminous coal (herein Powder River Basin (PRB) coal) and lignite, even with the use of selective catalytic reduction (SCR). The higher Hg(0)concentration in the flue gas makes it difficult to use the wet-FGD process for the mercury emission control in coal-fired utility boilers. Investigation of enhanced Hg(0) oxidation by addition of hydrogen halogens (HF, HCl, HBr, and HI) was conducted in a slipstream reactor with and without SCR catalysts when burning PRB coal. Two commercial SCR catalysts were evaluated. SCR catalyst no. 1 showed higher efficiencies of both NO reduction and Hg(0) oxidation than those of SCR catalyst no. 2. NH3 addition seemed to inhibit the Hg(0) oxidation, which indicated competitive processes between NH3 reduction and Hg(0) oxidation on the surface of SCR catalysts. The hydrogen halogens, in the order of impact on Hg(0) oxidation, were HBr, HI, and HCl or HF. Addition of HBr at approximately 3 ppm could achieve 80% Hg(0) oxidation. Addition of HI at approximately 5 ppm could achieve 40% Hg(0) oxidation. In comparison to the empty reactor, 40% Hg(0) oxidation could be achieved when HCl addition was up to 300 ppm. The enhanced Hg(0) oxidation by addition of HBr and HI seemed not to be correlated to the catalytic effects by both evaluated SCR catalysts. The effectiveness of conversion of hydrogen halogens to halogen molecules or interhalogens seemed to be attributed to their impacts on Hg(0) oxidation.
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http://dx.doi.org/10.1021/es071281eDOI Listing
January 2008
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