Publications by authors named "Quan-Zhen Li"

100Publications

Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

Authors:
Prithvi Raj Ran Song Honglin Zhu Linley Riediger Dong-Jae Jun Chaoying Liang Carlos Arana Bo Zhang Yajing Gao Benjamin E Wakeland Igor Dozmorov Jinchun Zhou Jennifer A Kelly Bernard R Lauwerys Joel M Guthridge Nancy J Olsen Swapan K Nath Chandrashekhar Pasare Nicolai van Oers Gary Gilkeson Betty P Tsao Patrick M Gaffney Peter K Gregersen Judith A James Xiaoxia Zuo David R Karp Quan-Zhen Li Edward K Wakeland

Genome Biol 2020 Nov 19;21(1):281. Epub 2020 Nov 19.

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1186/s13059-020-02184-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677828PMC
November 2020

Exploratory Study of Autoantibody Profiling in Drug-Induced Liver Injury with an Autoimmune Phenotype.

Authors:
Craig Lammert Chengsong Zhu Yun Lian Indu Raman George Eckert Quan-Zhen Li Naga Chalasani

Hepatol Commun 2020 Nov 1;4(11):1651-1663. Epub 2020 Sep 1.

Department of Medicine Indiana University School of Medicine Indianapolis IN USA.

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http://dx.doi.org/10.1002/hep4.1582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603536PMC
November 2020

Self-reactive antibodies associated with bronchiolitis obliterans syndrome subtype of chronic lung allograft dysfunction.

Authors:
Vaidehi Kaza Chengsong Zhu Lance S Terada Li Wang Fernando Torres Srinivas Bollineni Manish Mohanka Amit Banga John Joerns T Mohanakumar Quan-Zhen Li

Hum Immunol 2020 Oct 28. Epub 2020 Oct 28.

Department of Immunology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2020.10.006DOI Listing
October 2020

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.

Authors:
Jacob A Turner Emmanuel Stephen-Victor Sen Wang Magali Noval Rivas Azza Abdel-Gadir Hani Harb Ye Cui Manoussa Fanny Louis-Marie Charbonnier Jason Jun Hung Fong Mehdi Benamar Leighanne Wang Oliver T Burton Kushagra Bansal Lynn Bry Chengsong Zhu Quan-Zhen Li Rachel L Clement Hans C Oettgen Elena Crestani Rima Rachid Peter T Sage Talal A Chatila

Immunity 2020 Oct 20. Epub 2020 Oct 20.

Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.10.002DOI Listing
October 2020

An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells.

Authors:
Christian T Mayer Jan P Nieke Anna Gazumyan Melissa Cipolla Qiao Wang Thiago Y Oliveira Victor Ramos Sébastien Monette Quan-Zhen Li M Eric Gershwin Hamid Kashkar Michel C Nussenzweig

Proc Natl Acad Sci U S A 2020 10 22;117(40):24957-24963. Epub 2020 Sep 22.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.2015372117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547173PMC
October 2020

Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

Authors:
Shinya Tanaka Wataru Ise Takeshi Inoue Ayako Ito Chisato Ono Yoshihito Shima Shuhei Sakakibara Manabu Nakayama Kentaro Fujii Ikuo Miura Jafar Sharif Haruhiko Koseki Pandelakis A Koni Indu Raman Quan-Zhen Li Masato Kubo Katsunori Fujiki Ryuichiro Nakato Katsuhiko Shirahige Hiromitsu Araki Fumihito Miura Takashi Ito Eiryo Kawakami Yoshihiro Baba Tomohiro Kurosaki

Nat Immunol 2020 Dec;21(12):1611-1612

Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.

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http://dx.doi.org/10.1038/s41590-020-00809-wDOI Listing
December 2020

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice.

Authors:
Lichchavi D Rajasinghe Quan-Zhen Li Chengsong Zhu Mei Yan Preeti S Chauhan Kathryn A Wierenga Melissa A Bates Jack R Harkema Abby D Benninghoff James J Pestka

Autoimmunity 2020 Nov 9;53(7):415-433. Epub 2020 Sep 9.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.

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http://dx.doi.org/10.1080/08916934.2020.1801651DOI Listing
November 2020

SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity.

Authors:
William S Phipps Jeffrey A SoRelle Quan-Zhen Li Lenin Mahimainathan Ellen Araj John Markantonis Chantale Lacelle Jyoti Balani Hiren Parikh E Blair Solow David R Karp Ravi Sarode Alagarraju Muthukumar

Am J Clin Pathol 2020 09;154(4):459-465

Department of Pathology, University of Texas Southwestern Medical Center, Dallas.

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http://dx.doi.org/10.1093/ajcp/aqaa123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454292PMC
September 2020

Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.

Authors:
Ainhoa Perez-Diez Chun-Shu Wong Xiangdong Liu Harry Mystakelis Jian Song Yong Lu Virginia Sheikh Jeffrey S Bourgeois Andrea Lisco Elizabeth Laidlaw Cornelia Cudrici Chengsong Zhu Quan-Zhen Li Alexandra F Freeman Peter R Williamson Megan Anderson Gregg Roby John S Tsang Richard Siegel Irini Sereti

J Clin Invest 2020 Oct;130(10):5326-5337

HIV Pathogenesis Section, Laboratory of Immunoregulation, and.

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http://dx.doi.org/10.1172/JCI136254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524466PMC
October 2020

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

Authors:
Shinya Tanaka Wataru Ise Takeshi Inoue Ayako Ito Chisato Ono Yoshihito Shima Shuhei Sakakibara Manabu Nakayama Kentaro Fujii Ikuo Miura Jafar Sharif Haruhiko Koseki Pandelakis A Koni Indu Raman Quan-Zhen Li Masato Kubo Katsunori Fujiki Ryuichiro Nakato Katsuhiko Shirahige Hiromitsu Araki Fumihito Miura Takashi Ito Eiryo Kawakami Yoshihiro Baba Tomohiro Kurosaki

Nat Immunol 2020 08 22;21(8):950-961. Epub 2020 Jun 22.

Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.

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http://dx.doi.org/10.1038/s41590-020-0700-yDOI Listing
August 2020

Statin Intolerance, Anti-HMGCR Antibodies, and Immune Checkpoint Inhibitor-Associated Myositis: A "Two-Hit" Autoimmune Toxicity or Clinical Predisposition?

Authors:
Mitchell S von Itzstein Shaheen Khan Vinita Popat Rong Lu Saad A Khan Farjana J Fattah Jason Y Park Bonnie L Bermas David R Karp Murtaza Ahmed Jessica M Saltarski Yvonne Gloria-McCutchen Yang Xie Quan-Zhen Li Edward K Wakeland David E Gerber

Oncologist 2020 May 13. Epub 2020 May 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2019-0911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418340PMC
May 2020

Late-Onset Immunotherapy Toxicity and Delayed Autoantibody Changes: Checkpoint Inhibitor-Induced Raynaud's-Like Phenomenon.

Authors:
Shaheen Khan Mitchell S von Itzstein Rong Lu Bonnie L Bermas David R Karp Saad A Khan Farjana J Fattah Jason Y Park Jessica M Saltarski Yvonne Gloria-McCutchen Yang Xie Quan-Zhen Li Edward K Wakeland David E Gerber

Oncologist 2020 05 13;25(5):e753-e757. Epub 2020 Mar 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1634/theoncologist.2019-0666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216445PMC
May 2020

Pre-existing self-reactive IgA antibodies associated with primary graft dysfunction after lung transplantation.

Authors:
Vaidehi Kaza Chengsong Zhu Leying Feng Fernando Torres Srinivas Bollineni Manish Mohanka Amit Banga John Joerns T Mohanakumar Lance S Terada Quan-Zhen Li

Transpl Immunol 2020 04 30;59:101271. Epub 2020 Jan 30.

Department of Immunology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2020.101271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645846PMC
April 2020

Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.

Authors:
Sabira Mohammed Nalanda S Vineetha Shirley James Jayasekharan S Aparna Manendra Babu Lankadasari Takahiro Maeda Abhirupa Ghosh Sudipto Saha Quan-Zhen Li Sarah Spiegel Kuzhuvelil B Harikumar

FASEB J 2020 Mar 23;34(3):4329-4347. Epub 2020 Jan 23.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.

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http://dx.doi.org/10.1096/fj.201902847RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559288PMC
March 2020

Response to Potuijt et al.

Authors:
Peiqiang Su Caixia Xu Xiaoming Yang Hang Zhou Quan-Zhen Li

Genet Med 2020 04 11;22(4):819-820. Epub 2019 Dec 11.

Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41436-019-0726-4DOI Listing
April 2020

Functional Characterization of CD11c Age-Associated B Cells as Memory B Cells.

Authors:
Samuel W Du Tanvi Arkatkar Fahd Al Qureshah Holly M Jacobs Christopher D Thouvenel Kristy Chiang Andrea D Largent Quan-Zhen Li Baidong Hou David J Rawlings Shaun W Jackson

J Immunol 2019 12 21;203(11):2817-2826. Epub 2019 Oct 21.

Seattle Children's Research Institute, Seattle, WA 98101;

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http://dx.doi.org/10.4049/jimmunol.1900404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864310PMC
December 2019

CXCR5PD-1 follicular helper CD8 T cells control B cell tolerance.

Authors:
Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang

Nat Commun 2019 09 27;10(1):4415. Epub 2019 Sep 27.

Blood Research Institute, Versiti, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41467-019-12446-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765049PMC
September 2019

Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells.

Authors:
Marie Pouzolles Alice Machado Mickaël Guilbaud Magali Irla Sarah Gailhac Pierre Barennes Daniela Cesana Andrea Calabria Fabrizio Benedicenti Arnauld Sergé Indu Raman Quan-Zhen Li Eugenio Montini David Klatzmann Oumeya Adjali Naomi Taylor Valérie S Zimmermann

J Allergy Clin Immunol 2020 02 9;145(2):679-697.e5. Epub 2019 Sep 9.

Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193117
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http://dx.doi.org/10.1016/j.jaci.2019.08.029DOI Listing
February 2020

Body Mass Index Drives Changes in DNA Methylation: A Longitudinal Study.

Authors:
Dianjianyi Sun Tao Zhang Shaoyong Su Guang Hao Tao Chen Quan-Zhen Li Lydia Bazzano Jiang He Xiaoling Wang Shengxu Li Wei Chen

Circ Res 2019 10 12;125(9):824-833. Epub 2019 Sep 12.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (D.S., T.Z., L.B., J.H., W.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786955PMC
October 2019

Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus.

Authors:
Hui Luo Ling Wang Ding Bao Li Wang Hongjun Zhao Yun Lian Mei Yan Chandra Mohan Quan-Zhen Li

Genomics Proteomics Bioinformatics 2019 06 5;17(3):248-259. Epub 2019 Sep 5.

Department of Rheumatology, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16720229193012
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http://dx.doi.org/10.1016/j.gpb.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818352PMC
June 2019

Increased Serum Matrix Metalloproteinase-9 Levels are Associated with Anti-Jo1 but not Anti-MDA5 in Myositis Patients.

Authors:
Yanjuan Liu Hui Luo Li Wang Caiyan Li Liyun Liu Li Huang Ke Liu Meidong Liu Siming Gao Yizhi Xiao Honglin Zhu Xiaoxia Zuo Quan-Zhen Li Huali Zhang

Aging Dis 2019 Aug 1;10(4):746-755. Epub 2019 Aug 1.

1Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.14336/AD.2018.1120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675534PMC
August 2019

A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud.

Authors:
Caixia Xu Xiaoming Yang Hang Zhou Yongyong Li Chao Xing Taifeng Zhou Dongmei Zhong Chengjie Lian Mei Yan Tao Chen Zhiheng Liao Bo Gao Deying Su Tingting Wang Swarkar Sharma Chandra Mohan Nadav Ahituv Sajid Malik Quan-Zhen Li Peiqiang Su

Genet Med 2020 01 9;22(1):189-198. Epub 2019 Aug 9.

Department of Orthopedics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.

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http://dx.doi.org/10.1038/s41436-019-0626-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944640PMC
January 2020

Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function.

Authors:
Xingwang Zhao Hengyi Xie Meng Zhao Asma Ahsan Xinxin Li Fei Wang Junyang Yi Zhiyong Yang Chuan Wu Indu Raman Quan-Zhen Li Tae Jin Kim Wanli Liu

Sci Adv 2019 07 17;5(7):eaaw0315. Epub 2019 Jul 17.

MOE Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1126/sciadv.aaw0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637015PMC
July 2019

High Expression Drives the Expansion of CD19CD24CD38 Transitional B Cells and Autoantibody Production in SLE Patients.

Authors:
Ting Wang John Marken Janice Chen Van Bao Tran Quan-Zhen Li Mengtao Li Karen Cerosaletti Keith B Elkon Xiaofeng Zeng Natalia V Giltiay

Front Immunol 2019 4;10:1243. Epub 2019 Jun 4.

Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559307PMC
October 2020

The function of ncRNAs in rheumatic diseases.

Authors:
Weilin Chen Di Liu Quan-Zhen Li Honglin Zhu

Epigenomics 2019 05 7;11(7):821-833. Epub 2019 Jun 7.

Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, PR China.

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http://dx.doi.org/10.2217/epi-2018-0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595547PMC
May 2019

A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First-Degree Relatives of Systemic Lupus Erythematosus Patients.

Authors:
Elizabeth Ogunrinde Zejun Zhou Zhenwu Luo Alexander Alekseyenko Quan-Zhen Li Danielle Macedo Diane L Kamen Jim C Oates Gary S Gilkeson Wei Jiang

Arthritis Rheumatol 2019 11 27;71(11):1858-1868. Epub 2019 Sep 27.

Medical University of South Carolina, Charleston.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40935
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http://dx.doi.org/10.1002/art.40935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817371PMC
November 2019

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.

Authors:
Julio E Molineros Loren L Looger Kwangwoo Kim Yukinori Okada Chikashi Terao Celi Sun Xu-Jie Zhou Prithvi Raj Yuta Kochi Akari Suzuki Shuji Akizuki Shuichiro Nakabo So-Young Bang Hye-Soon Lee Young Mo Kang Chang-Hee Suh Won Tae Chung Yong-Beom Park Jung-Yoon Choe Seung-Cheol Shim Shin-Seok Lee Xiaoxia Zuo Kazuhiko Yamamoto Quan-Zhen Li Nan Shen Lauren L Porter John B Harley Kek Heng Chua Hong Zhang Edward K Wakeland Betty P Tsao Sang-Cheol Bae Swapan K Nath

PLoS Genet 2019 04 25;15(4):e1008092. Epub 2019 Apr 25.

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504188PMC
April 2019

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.

Authors:
Sabira Mohammed Nalanda S Vineetha Shirley James Jayasekharan S Aparna Manendra Babu Lankadasari Jeremy C Allegood Quan-Zhen Li Sarah Spiegel Kuzhuvelil B Harikumar

FASEB J 2019 06 6;33(6):7061-7071. Epub 2019 Mar 6.

Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, India.

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http://dx.doi.org/10.1096/fj.201802535RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529345PMC
June 2019

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease.

Authors:
Zhenwu Luo Min Li Yongxia Wu Zhefeng Meng Lisa Martin Lumin Zhang Elizabeth Ogunrinde Zejun Zhou Shenghui Qin Zhuang Wan Maria Anna Julia Westerink Stephanie Warth Hui Liu Ping Jin David Stroncek Quan-Zhen Li Ena Wang Xueling Wu Sonya L Heath Zihai Li Alexander V Alekseyenko Wei Jiang

Microbiome 2019 02 14;7(1):25. Epub 2019 Feb 14.

Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Ave. BSB208D, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1186/s40168-019-0646-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376754PMC
February 2019

Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis.

Authors:
Honglin Zhu Chengsong Zhu Wentao Mi Tao Chen Hongjun Zhao Xiaoxia Zuo Hui Luo Quan-Zhen Li

Int J Rheumatol 2018 2;2018:7342472. Epub 2018 Sep 2.

Department of Rheumatology & Immunology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.

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http://dx.doi.org/10.1155/2018/7342472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139224PMC
September 2018

Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody-Negative Eosinophilic Granulomatosis with Polyangiitis.

Authors:
Manali Mukherjee Sruthi R Thomas Katherine Radford Anna Dvorkin-Gheva Svetlana Davydchenko Melanie Kjarsgaard Sarah Svenningsen Sarah Almas Lindsey C Felix Jennifer Stearns Quan-Zhen Li Nader Khalidi Paige Lacy Parameswaran K Nair

Am J Respir Crit Care Med 2019 01;199(2):158-170

1 Department of Medicine and.

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http://dx.doi.org/10.1164/rccm.201804-0809OCDOI Listing
January 2019

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Authors:
Silvia Preite Jennifer L Cannons Andrea J Radtke Ivan Vujkovic-Cvijin Julio Gomez-Rodriguez Stefano Volpi Bonnie Huang Jun Cheng Nicholas Collins Julie Reilley Robin Handon Kerry Dobbs Lutfi Huq Indu Raman Chengsong Zhu Quan-Zhen Li Ming O Li Stefania Pittaluga Gulbu Uzel Luigi D Notarangelo Yasmine Belkaid Ronald N Germain Pamela L Schwartzberg

Nat Immunol 2018 09 20;19(9):986-1000. Epub 2018 Aug 20.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41590-018-0182-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140795PMC
September 2018

IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1.

Authors:
Victoria L Palmer Alexandra N Worth Robyn L Scott Greg A Perry Mei Yan Quan-Zhen Li Patrick C Swanson

Cell Immunol 2018 09 13;331:110-120. Epub 2018 Jun 13.

Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189341PMC
September 2018

Foxo3 Promotes Apoptosis of B Cell Receptor-Stimulated Immature B Cells, Thus Limiting the Window for Receptor Editing.

Authors:
Kristina Ottens Rochelle M Hinman Evan Barrios Brian Skaug Laurie S Davis Quan-Zhen Li Diego H Castrillon Anne B Satterthwaite

J Immunol 2018 08 27;201(3):940-949. Epub 2018 Jun 27.

Rheumatic Diseases Division, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701070
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http://dx.doi.org/10.4049/jimmunol.1701070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057821PMC
August 2018

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

Authors:
Yingying Zhang Aaron Burberry Jin-Yuan Wang Jackson Sandoe Sulagna Ghosh Namrata D Udeshi Tanya Svinkina Daniel A Mordes Joanie Mok Maura Charlton Quan-Zhen Li Steven A Carr Kevin Eggan

Genes Dev 2018 07 27;32(13-14):929-943. Epub 2018 Jun 27.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.313932.118
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http://dx.doi.org/10.1101/gad.313932.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075033PMC
July 2018

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.

Authors:
Tanvi Arkatkar Holly M Jacobs Samuel W Du Quan-Zhen Li Kelly L Hudkins Charles E Alpers David J Rawlings Shaun W Jackson

Kidney Int 2018 10 12;94(4):728-740. Epub 2018 Jun 12.

Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151274PMC
October 2018

Circadian clock cryptochrome proteins regulate autoimmunity.

Authors:
Qi Cao Xuan Zhao Jingwen Bai Sigal Gery Haibo Sun De-Chen Lin Qi Chen Zhengshan Chen Lauren Mack Henry Yang Ruishu Deng Xianping Shi Ling-Wa Chong Han Cho Jianjun Xie Quan-Zhen Li Markus Müschen Annette R Atkins Christopher Liddle Ruth T Yu Serhan Alkan Jonathan W Said Ye Zheng Michael Downes Ronald M Evans H Phillip Koeffler

Proc Natl Acad Sci U S A 2017 11 6;114(47):12548-12553. Epub 2017 Nov 6.

Department of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.

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http://dx.doi.org/10.1073/pnas.1619119114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703267PMC
November 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis.

Authors:
Wenjie Gao Chong Chen Taifeng Zhou Shulan Yang Bo Gao Hang Zhou Chengjie Lian Zizhao Wu Xianjian Qiu Xiaoming Yang Esam Alattar Wentao Liu Deying Su Silong Sun Yulan Chen Kenneth M C Cheung Youqiang Song Keith K D Luk Danny Chan Pak Chung Sham Chao Xing Chiea Chuen Khor Gabriel Liu Junlin Yang Yubin Deng Dingjun Hao Dongsheng Huang Quan-Zhen Li Caixia Xu Peiqiang Su

Hum Mutat 2017 11 25;38(11):1500-1510. Epub 2017 Jul 25.

Department of Orthopaedic Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/humu.23296DOI Listing
November 2017

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy.

Authors:
Susana L Silva Adriana Albuquerque Andreia J Amaral Quan-Zhen Li Catarina Mota Rémi Cheynier Rui M M Victorino M Conceição Pereira-Santos Ana E Sousa

PLoS One 2017 7;12(7):e0180385. Epub 2017 Jul 7.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa. Lisboa, Portugal.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501530PMC
September 2017

Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2/J mouse model.

Authors:
Jeremy Kiripolsky Long Shen Yichen Liang Alisa Li Lakshmanan Suresh Yun Lian Quan-Zhen Li Daniel P Gaile Jill M Kramer

Clin Immunol 2017 10 17;183:225-232. Epub 2017 May 17.

Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA; Department of Oral Diagnostics Sciences, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082154PMC
October 2017

Protein array autoantibody profiles to determine diagnostic markers for neuropsychiatric systemic lupus erythematosus.

Authors:
Pomme M van der Meulen Anouk M Barendregt Eloy Cuadrado César Magro-Checa Gerda M Steup-Beekman Dieneke Schonenberg-Meinema J Merlijn Van den Berg Quan-Zhen Li Paul A Baars Diana Wouters Alexandre E Voskuyl Ineke R J M Ten Berge Tom W J Huizinga Taco W Kuijpers

Rheumatology (Oxford) 2017 08;56(8):1407-1416

Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital Academic Medical Center.

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http://dx.doi.org/10.1093/rheumatology/kex073DOI Listing
August 2017

TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus.

Authors:
Hongjun Zhao Lijing Wang Hui Luo Quan-Zhen Li Xiaoxia Zuo

Rheumatology (Oxford) 2017 05;56(5):835-843

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China.

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http://dx.doi.org/10.1093/rheumatology/kew508DOI Listing
May 2017

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.

Authors:
Jian Zhao Jianyang Ma Yun Deng Jennifer A Kelly Kwangwoo Kim So-Young Bang Hye-Soon Lee Quan-Zhen Li Edward K Wakeland Rong Qiu Mengru Liu Jianping Guo Zhanguo Li Wenfeng Tan Astrid Rasmussen Christopher J Lessard Kathy L Sivils Bevra H Hahn Jennifer M Grossman Diane L Kamen Gary S Gilkeson Sang-Cheol Bae Patrick M Gaffney Nan Shen Betty P Tsao

Nat Genet 2017 Mar 30;49(3):433-437. Epub 2017 Jan 30.

Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1038/ng.3782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400098PMC
March 2017

Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment.

Authors:
Nancy J Olsen Carl McAloose Jamie Carter Bobby Kwanghoon Han Indu Raman Quan-Zhen Li Duanping Liao

Autoimmune Dis 2016 28;2016:8791629. Epub 2016 Dec 28.

Department of Public Health Sciences, Penn State University, College of Medicine, Hershey, PA, USA.

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December 2016

Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Authors:
Jennifer Martinez Larissa D Cunha Sunmin Park Mao Yang Qun Lu Robert Orchard Quan-Zhen Li Mei Yan Laura Janke Cliff Guy Andreas Linkermann Herbert W Virgin Douglas R Green

Nature 2016 11 28;539(7627):124. Epub 2016 Sep 28.

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November 2016

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Authors:
Aaron Burberry Naoki Suzuki Jin-Yuan Wang Rob Moccia Daniel A Mordes Morag H Stewart Satomi Suzuki-Uematsu Sulagna Ghosh Ajay Singh Florian T Merkle Kathryn Koszka Quan-Zhen Li Leonard Zon Derrick J Rossi Jennifer J Trowbridge Luigi D Notarangelo Kevin Eggan

Sci Transl Med 2016 07;8(347):347ra93

Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf6038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024536PMC
July 2016

Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus.

Authors:
Honglin Zhu Wentao Mi Hui Luo Tao Chen Shengxi Liu Indu Raman Xiaoxia Zuo Quan-Zhen Li

Arthritis Res Ther 2016 07 13;18:162. Epub 2016 Jul 13.

Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China.

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http://dx.doi.org/10.1186/s13075-016-1050-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942934PMC
July 2016

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Authors:
Jennifer Martinez Larissa D Cunha Sunmin Park Mao Yang Qun Lu Robert Orchard Quan-Zhen Li Mei Yan Laura Janke Cliff Guy Andreas Linkermann Herbert W Virgin Douglas R Green

Nature 2016 May 20;533(7601):115-9. Epub 2016 Apr 20.

Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature17950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860026PMC
May 2016

Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.

Authors:
Tianfu Wu Chun Xie Jie Han Yujin Ye Sandeep Singh Jinchun Zhou Yajuan Li Huihua Ding Quan-zhen Li Xin Zhou Chaim Putterman Ramesh Saxena Chandra Mohan

PLoS One 2016 28;11(3):e0151491. Epub 2016 Mar 28.

Department of Biomedical Engineering, University of Houston, Houston, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809566PMC
August 2016

TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism.

Authors:
Anping Xu Ya Liu Weiqian Chen Julie Wang Youqiu Xue Feng Huang Liming Rong Jin Lin Dahai Liu Mei Yan Quan-Zhen Li Bin Li Jianxun Song Nancy Olsen Song Guo Zheng

J Immunol 2016 05 21;196(9):3631-41. Epub 2016 Mar 21.

Center for Clinic Immunology, Third Hospital, Sun Yat-sen University, Guangzhou 510630, China; Division of Rheumatology, Department of Medicine, Penn State University Hershey College of Medicine, Hershey, PA 17033;

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http://dx.doi.org/10.4049/jimmunol.1501740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868785PMC
May 2016

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

Authors:
Prithvi Raj Ekta Rai Ran Song Shaheen Khan Benjamin E Wakeland Kasthuribai Viswanathan Carlos Arana Chaoying Liang Bo Zhang Igor Dozmorov Ferdicia Carr-Johnson Mitja Mitrovic Graham B Wiley Jennifer A Kelly Bernard R Lauwerys Nancy J Olsen Chris Cotsapas Christine K Garcia Carol A Wise John B Harley Swapan K Nath Judith A James Chaim O Jacob Betty P Tsao Chandrashekhar Pasare David R Karp Quan Zhen Li Patrick M Gaffney Edward K Wakeland

Elife 2016 Feb 15;5. Epub 2016 Feb 15.

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States.

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http://dx.doi.org/10.7554/eLife.12089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811771PMC
February 2016

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.

Authors:
Simanta Pathak Kirthi Raman Kumar Hasna Kanta Ferdicia Carr-Johnson Jie Han Anna Bashmakov Lionel Faure Huihua Ding Kamala Vanarsa Shaheen Khan Quan-Zhen Li Kent Chapman Edward K Wakeland Chandra Mohan

J Immunol 2016 Feb 15;196(4):1507-16. Epub 2016 Jan 15.

Division of Rheumatic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Biomedical Engineering, University of Houston, Houston, TX 77204; Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and

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February 2016

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.

Authors:
Christopher J Lessard Satria Sajuthi Jian Zhao Kwangwoo Kim John A Ice He Li Hannah Ainsworth Astrid Rasmussen Jennifer A Kelly Mindy Marion So-Young Bang Young Bin Joo Jeongim Choi Hye-Soon Lee Young Mo Kang Chang-Hee Suh Won Tae Chung Soo-Kon Lee Jung-Yoon Choe Seung Cheol Shim Ji Hee Oh Young Jin Kim Bok-Ghee Han Nan Shen Hwee Siew Howe Edward K Wakeland Quan-Zhen Li Yeong Wook Song Patrick M Gaffney Marta E Alarcón-Riquelme Lindsey A Criswell Chaim O Jacob Robert P Kimberly Timothy J Vyse John B Harley Kathy L Sivils Sang-Cheol Bae Carl D Langefeld Betty P Tsao

Arthritis Rheumatol 2016 05;68(5):1197-1209

Division of Rheumatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/art.39548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981330PMC
May 2016

A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma.

Authors:
Jin-Huan Wei Ahmed Haddad Kai-Jie Wu Hong-Wei Zhao Payal Kapur Zhi-Ling Zhang Liang-Yun Zhao Zhen-Hua Chen Yun-Yun Zhou Jian-Cheng Zhou Bin Wang Yan-Hong Yu Mu-Yan Cai Dan Xie Bing Liao Cai-Xia Li Pei-Xing Li Zong-Ren Wang Fang-Jian Zhou Lei Shi Qing-Zuo Liu Zhen-Li Gao Da-Lin He Wei Chen Jer-Tsong Hsieh Quan-Zhen Li Vitaly Margulis Jun-Hang Luo

Nat Commun 2015 Oct 30;6:8699. Epub 2015 Oct 30.

Department of Urology, First Affiliated Hospital, Sun Yat-sen University, No. 58, ZhongShan Second Road, Guangdong 510080, China.

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http://dx.doi.org/10.1038/ncomms9699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846314PMC
October 2015

Autoimmune Diseases in the Bioinformatics Paradigm. Preface.

Authors:
Quan-Zhen Li Edward K Wakeland

Genomics Proteomics Bioinformatics 2015 Aug 1;13(4):205-7. Epub 2015 Oct 1.

Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610968PMC
August 2015

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice.

Authors:
Maroof Hasan Nicole Dobbs Shaheen Khan Michael A White Edward K Wakeland Quan-Zhen Li Nan Yan

J Immunol 2015 Nov 2;195(10):4573-7. Epub 2015 Oct 2.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.4049/jimmunol.1500162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635567PMC
November 2015

Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus.

Authors:
Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li

Genomics Proteomics Bioinformatics 2015 Aug 28;13(4):210-8. Epub 2015 Sep 28.

Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610965PMC
August 2015

Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome.

Authors:
Jill M Kramer Nichol E Holodick Teresa C Vizconde Indu Raman Mei Yan Quan-Zhen Li Daniel P Gaile Thomas L Rothstein

J Leukoc Biol 2016 Feb 17;99(2):321-31. Epub 2015 Sep 17.

*Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA; Division of Oral and Maxillofacial Pathology, Department of Dental Medicine, Long Island Jewish Medical Center, New Hyde Park, New York, USA; Department of Oral Biology, School of Dental Medicine, and Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York, USA; Department of Dental Medicine and Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York, USA; and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1189/jlb.2A0715-297RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718196PMC
February 2016

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.

Authors:
Daxing Gao Tuo Li Xiao-Dong Li Xiang Chen Quan-Zhen Li Mary Wight-Carter Zhijian J Chen

Proc Natl Acad Sci U S A 2015 Oct 14;112(42):E5699-705. Epub 2015 Sep 14.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;

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http://dx.doi.org/10.1073/pnas.1516465112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620884PMC
October 2015

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Authors:
Maroof Hasan Charles S Fermaintt Ningguo Gao Tomomi Sakai Takuya Miyazaki Sixin Jiang Quan-Zhen Li John P Atkinson Herbert C Morse Mark A Lehrman Nan Yan

Immunity 2015 Sep 25;43(3):463-74. Epub 2015 Aug 25.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575271PMC
September 2015

Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.

Authors:
Jessica Mayeux Brian Skaug Wei Luo Lisa M Russell Shinu John Prontip Saelee Hansaa Abbasi Quan-Zhen Li Lee Ann Garrett-Sinha Anne B Satterthwaite

J Immunol 2015 Sep 24;195(5):1955-63. Epub 2015 Jul 24.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546901PMC
September 2015

Delivering Oxidation Resistance-1 (OXR1) to Mouse Kidney by Genetic Modified Mesenchymal Stem Cells Exhibited Enhanced Protection against Nephrotoxic Serum Induced Renal Injury and Lupus Nephritis.

Authors:
Yajuan Li Wei Li Chu Liu Mei Yan Indu Raman Yong Du Xiangdong Fang Xin J Zhou Chandra Mohan Quan-Zhen Li

J Stem Cell Res Ther 2014 Sep;4(9)

Key Laboratory of Medical Genetics, Wenzhou Medical University School of Laboratory Medicine & Life Science, Wenzhou, 325035, China ; Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.4172/2157-7633.1000231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435960PMC
September 2014

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.

Authors:
Qi-Quan Huang Harris Perlman Robert Birkett Renee Doyle Deyu Fang G Kenneth Haines William Robinson Syamal Datta Zan Huang Quan-Zhen Li Hyewon Phee Richard M Pope

Nat Commun 2015 May 12;6:7086. Epub 2015 May 12.

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/ncomms8086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429912PMC
May 2015

A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture.

Authors:
Lingxiang Zhu Dingxia Shen Qiming Zhou Zexia Li Xiangdong Fang Quan-Zhen Li

PLoS One 2015 16;10(3):e0120464. Epub 2015 Mar 16.

Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361058PMC
October 2015

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

Authors:
Rebecca Baum Shruti Sharma Susan Carpenter Quan-Zhen Li Patricia Busto Katherine A Fitzgerald Ann Marshak-Rothstein Ellen M Gravallese

J Immunol 2015 Feb 29;194(3):873-7. Epub 2014 Dec 29.

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.4049/jimmunol.1402573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299698PMC
February 2015

Sertraline induces endoplasmic reticulum stress in hepatic cells.

Authors:
Si Chen Jiekun Xuan Letha Couch Advait Iyer Yuanfeng Wu Quan-Zhen Li Lei Guo

Toxicology 2014 Aug 24;322:78-88. Epub 2014 May 24.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736318PMC
August 2014

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

Authors:
Shaun W Jackson Nicole E Scharping Nikita S Kolhatkar Socheath Khim Marc A Schwartz Quan-Zhen Li Kelly L Hudkins Charles E Alpers Denny Liggitt David J Rawlings

J Immunol 2014 May 7;192(10):4525-32. Epub 2014 Apr 7.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041708PMC
May 2014

Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation.

Authors:
Yajuan Li Mei Yan Jichen Yang Indu Raman Yong Du Soyoun Min Xiangdong Fang Chandra Mohan Quan-Zhen Li

Stem Cell Res Ther 2014 Jan 30;5(1):19. Epub 2014 Jan 30.

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http://dx.doi.org/10.1186/scrt408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055015PMC
January 2014

Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates.

Authors:
Jiexia Quan Akshai Lakhanpal M Muralidhar Reddy Sayed Zaman Quan-Zhen Li Dwight C German Nancy J Olsen Thomas Kodadek David R Karp

J Immunol Methods 2014 Jan 20;402(1-2):23-34. Epub 2013 Nov 20.

Department of Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; The Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, USA; The Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2013.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946867PMC
January 2014

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.

Authors:
Xana Kim-Howard Celi Sun Julio E Molineros Amit K Maiti Hema Chandru Adam Adler Graham B Wiley Kenneth M Kaufman Leah Kottyan Joel M Guthridge Astrid Rasmussen Jennifer Kelly Elena Sánchez Prithvi Raj Quan-Zhen Li So-Young Bang Hye-Soon Lee Tae-Hwan Kim Young Mo Kang Chang-Hee Suh Won Tae Chung Yong-Beom Park Jung-Yoon Choe Seung Cheol Shim Shin-Seok Lee Bok-Ghee Han Nancy J Olsen David R Karp Kathy Moser Bernardo A Pons-Estel Edward K Wakeland Judith A James John B Harley Sang-Cheol Bae Patrick M Gaffney Marta Alarcón-Riquelme Loren L Looger Swapan K Nath

Hum Mol Genet 2014 Mar 26;23(6):1656-68. Epub 2013 Oct 26.

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1093/hmg/ddt532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929085PMC
March 2014

Universal Probe Library based real-time PCR for rapid detection of bacterial pathogens from positive blood culture bottles.

Authors:
Lingxiang Zhu Ding-Xia Shen Qiming Zhou Chao-Jun Liu Zexia Li Xiangdong Fang Quan-Zhen Li

World J Microbiol Biotechnol 2014 Mar;30(3):967-75

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March 2014

Enoyl coenzyme a hydratase domain-containing 2, a potential novel regulator of myocardial ischemia injury.

Authors:
Jianhai Du Zhixin Li Quan-Zhen Li Tongju Guan Qiuhui Yang Hao Xu Kirkwood A Pritchard Amadou K S Camara Yang Shi

J Am Heart Assoc 2013 Oct 9;2(5):e000233. Epub 2013 Oct 9.

Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1161/JAHA.113.000233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835224PMC
October 2013

Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.

Authors:
Christopher Richardson Asiya Seema Chida Diana Adlowitz Lin Silver Erin Fox Scott A Jenks Elise Palmer Youliang Wang Jamie Heimburg-Molinaro Quan-Zhen Li Chandra Mohan Richard Cummings Christopher Tipton Ignacio Sanz

J Immunol 2013 Nov 9;191(10):4926-39. Epub 2013 Oct 9.

Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine, Rochester, NY 14642;

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http://dx.doi.org/10.4049/jimmunol.1202263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816606PMC
November 2013

Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

Authors:
Yajuan Li Indu Raman Yong Du Mei Yan Soyoun Min Jichen Yang Xiangdong Fang Wei Li Jianxin Lu Xin J Zhou Chandra Mohan Quan-Zhen Li

PLoS One 2013 23;8(7):e67790. Epub 2013 Jul 23.

Department of Immunology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720854PMC
March 2014

Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.

Authors:
Lukas Bossaller Vijay A K Rathinam Ramon Bonegio Ping-I Chiang Patricia Busto Adam R Wespiser Daniel R Caffrey Quan-Zhen Li Chandra Mohan Katherine A Fitzgerald Eicke Latz Ann Marshak-Rothstein

J Immunol 2013 Sep 5;191(5):2104-14. Epub 2013 Aug 5.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.4049/jimmunol.1300341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219920PMC
September 2013

SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature.

Authors:
Amy M Becker Kathryn H Dao Bobby Kwanghoon Han Roger Kornu Shuchi Lakhanpal Angela B Mobley Quan-Zhen Li Yun Lian Tianfu Wu Andreas M Reimold Nancy J Olsen David R Karp Fatema Z Chowdhury J David Farrar Anne B Satterthwaite Chandra Mohan Peter E Lipsky Edward K Wakeland Laurie S Davis

PLoS One 2013 24;8(6):e67003. Epub 2013 Jun 24.

Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691135PMC
February 2014

Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.

Authors:
Lingxiang Zhu Zhongqiang Yan Zhaojun Zhang Qiming Zhou Jinchun Zhou Edward K Wakeland Xiangdong Fang Zhenyu Xuan Dingxia Shen Quan-Zhen Li

PLoS One 2013 24;8(6):e66584. Epub 2013 Jun 24.

Department of Immunology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691203PMC
March 2014

Biomarker profiling for lupus nephritis.

Authors:
Yajuan Li Xiangdong Fang Quan-Zhen Li

Genomics Proteomics Bioinformatics 2013 Jun 1;11(3):158-65. Epub 2013 Jun 1.

Department of Immunology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.gpb.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357827PMC
June 2013

Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.

Authors:
Satoko Arai Natsumi Maehara Yoshihiro Iwamura Shin-ichiro Honda Katsuhiko Nakashima Toshihiro Kai Masato Ogishi Kumiko Morita Jun Kurokawa Mayumi Mori Yuji Motoi Kensuke Miyake Nobuyuki Matsuhashi Ken-ichi Yamamura Osamu Ohara Akira Shibuya Edward K Wakeland Quan-Zhen Li Toru Miyazaki

Cell Rep 2013 Apr 4;3(4):1187-98. Epub 2013 Apr 4.

Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1016/j.celrep.2013.03.006DOI Listing
April 2013

Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.

Authors:
Xinli Shao Ru Yang Mei Yan Yajuan Li Yong Du Indu Raman Bo Zhang Edward K Wakeland Ward Wakeland Peter Igarashi Chandra Mohan Quan-Zhen Li

Arthritis Rheum 2013 Mar;65(3):780-91

University of Texas-Southwestern Medical Center, Dallas, TX 75235, USA.

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http://dx.doi.org/10.1002/art.37798DOI Listing
March 2013

Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain.

Authors:
Fang Liu Lei Guo Jie Zhang Shuo W Rainosek Leming Shi Tucker A Patterson Quan-Zhen Li Natalya Sadovova Joseph P Hanig Merle G Paule William Slikker Cheng Wang

Syst Pharmacol 2013 1;1:1-9. Epub 2013 Jan 1.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079 USA.

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http://dx.doi.org/10.2478/sph-2012-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755976PMC
January 2013

IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.

Authors:
Toni Gutierrez Jessica M Mayeux Sterling B Ortega Nitin J Karandikar Quan-Zhen Li Dinesh Rakheja Xin J Zhou Anne B Satterthwaite

Eur J Immunol 2013 Feb 18;43(2):382-93. Epub 2012 Dec 18.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8884, USA.

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http://dx.doi.org/10.1002/eji.201142095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768150PMC
February 2013

Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians.

Authors:
Rachel Kaiser Kimberly E Taylor Yun Deng Jian Zhao Yonghong Li Joanne Nititham Monica Chang Joseph Catanese Ann B Begovich Elizabeth E Brown Jeffrey C Edberg Gerald McGwin Graciela S Alarcón Rosalind Ramsey-Goldman John D Reveille Luis M Vila Michelle Petri Robert P Kimberly Xuebing Feng Lingyun Sun Nan Shen Wei Li Jian-Xin Lu Edward K Wakeland Quan-Zhen Li Wanling Yang Yu-Lung Lau Fei-Lan Liu Deh-Ming Chang Chack-Yung Yu Yeong W Song Betty P Tsao Lindsey A Criswell

Arthritis Rheum 2013 Jan;65(1):211-5

University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1002/art.37751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670944PMC
January 2013

The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.

Authors:
Yumin Xia Rahul D Pawar Antonio S Nakouzi Leal Herlitz Anna Broder Kui Liu Beatrice Goilav Manxia Fan Ling Wang Quan-Zhen Li Arturo Casadevall Chaim Putterman

J Autoimmun 2012 Dec 28;39(4):398-411. Epub 2012 Jul 28.

The Department of Microbiology & Immunology, Albert Einstein College of Medicine (AECOM), Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656415PMC
December 2012

Autoantibody profiling to follow evolution of lupus syndromes.

Authors:
Nancy J Olsen Quan-Zhen Li Jiexia Quan Ling Wang Azza Mutwally David R Karp

Arthritis Res Ther 2012 Jul 27;14(4):R174. Epub 2012 Jul 27.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580568PMC
July 2012

Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.

Authors:
Shannon K O'Neill Andrew Getahun Stephen B Gauld Kevin T Merrell Idan Tamir Mia J Smith Joseph M Dal Porto Quan-Zhen Li John C Cambier

Immunity 2011 Nov 9;35(5):746-56. Epub 2011 Nov 9.

Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232011PMC
November 2011

Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps.

Authors:
Bruce K Tan Quan-Zhen Li Lydia Suh Atsushi Kato David B Conley Rakesh K Chandra Jinchun Zhou James Norton Roderick Carter Monique Hinchcliff Kathleen Harris Anju Peters Leslie C Grammer Robert C Kern Chandra Mohan Robert P Schleimer

J Allergy Clin Immunol 2011 Dec 13;128(6):1198-1206.e1. Epub 2011 Oct 13.

Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.jaci.2011.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384688PMC
December 2011

Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys.

Authors:
Zhenqiang Su Zhiguang Li Tao Chen Quan-Zhen Li Hong Fang Don Ding Weigong Ge Baitang Ning Huixiao Hong Roger G Perkins Weida Tong Leming Shi

Chem Res Toxicol 2011 Sep 23;24(9):1486-93. Epub 2011 Aug 23.

ICF International at FDA's National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.

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September 2011

Risk factors for ANA positivity in healthy persons.

Authors:
Quan-Zhen Li David R Karp Jiexia Quan Valerie K Branch Jinchun Zhou Yun Lian Benjamin F Chong Edward K Wakeland Nancy J Olsen

Arthritis Res Ther 2011 Mar 2;13(2):R38. Epub 2011 Mar 2.

Department of Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390-9093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132017PMC
March 2011

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.

Authors:
Swarkar Sharma Xiaochong Gao Douglas Londono Shonn E Devroy Kristen N Mauldin Jessica T Frankel January M Brandon Dongping Zhang Quan-Zhen Li Matthew B Dobbs Christina A Gurnett Struan F A Grant Hakon Hakonarson John P Dormans John A Herring Derek Gordon Carol A Wise

Hum Mol Genet 2011 Apr 7;20(7):1456-66. Epub 2011 Jan 7.

Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA.

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http://dx.doi.org/10.1093/hmg/ddq571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049353PMC
April 2011

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.

Authors:
Leming Shi Gregory Campbell Wendell D Jones Fabien Campagne Zhining Wen Stephen J Walker Zhenqiang Su Tzu-Ming Chu Federico M Goodsaid Lajos Pusztai John D Shaughnessy André Oberthuer Russell S Thomas Richard S Paules Mark Fielden Bart Barlogie Weijie Chen Pan Du Matthias Fischer Cesare Furlanello Brandon D Gallas Xijin Ge Dalila B Megherbi W Fraser Symmans May D Wang John Zhang Hans Bitter Benedikt Brors Pierre R Bushel Max Bylesjo Minjun Chen Jie Cheng Jing Cheng Jeff Chou Timothy S Davison Mauro Delorenzi Youping Deng Viswanath Devanarayan David J Dix Joaquin Dopazo Kevin C Dorff Fathi Elloumi Jianqing Fan Shicai Fan Xiaohui Fan Hong Fang Nina Gonzaludo Kenneth R Hess Huixiao Hong Jun Huan Rafael A Irizarry Richard Judson Dilafruz Juraeva Samir Lababidi Christophe G Lambert Li Li Yanen Li Zhen Li Simon M Lin Guozhen Liu Edward K Lobenhofer Jun Luo Wen Luo Matthew N McCall Yuri Nikolsky Gene A Pennello Roger G Perkins Reena Philip Vlad Popovici Nathan D Price Feng Qian Andreas Scherer Tieliu Shi Weiwei Shi Jaeyun Sung Danielle Thierry-Mieg Jean Thierry-Mieg Venkata Thodima Johan Trygg Lakshmi Vishnuvajjala Sue Jane Wang Jianping Wu Yichao Wu Qian Xie Waleed A Yousef Liang Zhang Xuegong Zhang Sheng Zhong Yiming Zhou Sheng Zhu Dhivya Arasappan Wenjun Bao Anne Bergstrom Lucas Frank Berthold Richard J Brennan Andreas Buness Jennifer G Catalano Chang Chang Rong Chen Yiyu Cheng Jian Cui Wendy Czika Francesca Demichelis Xutao Deng Damir Dosymbekov Roland Eils Yang Feng Jennifer Fostel Stephanie Fulmer-Smentek James C Fuscoe Laurent Gatto Weigong Ge Darlene R Goldstein Li Guo Donald N Halbert Jing Han Stephen C Harris Christos Hatzis Damir Herman Jianping Huang Roderick V Jensen Rui Jiang Charles D Johnson Giuseppe Jurman Yvonne Kahlert Sadik A Khuder Matthias Kohl Jianying Li Li Li Menglong Li Quan-Zhen Li Shao Li Zhiguang Li Jie Liu Ying Liu Zhichao Liu Lu Meng Manuel Madera Francisco Martinez-Murillo Ignacio Medina Joseph Meehan Kelci Miclaus Richard A Moffitt David Montaner Piali Mukherjee George J Mulligan Padraic Neville Tatiana Nikolskaya Baitang Ning Grier P Page Joel Parker R Mitchell Parry Xuejun Peng Ron L Peterson John H Phan Brian Quanz Yi Ren Samantha Riccadonna Alan H Roter Frank W Samuelson Martin M Schumacher Joseph D Shambaugh Qiang Shi Richard Shippy Shengzhu Si Aaron Smalter Christos Sotiriou Mat Soukup Frank Staedtler Guido Steiner Todd H Stokes Qinglan Sun Pei-Yi Tan Rong Tang Zivana Tezak Brett Thorn Marina Tsyganova Yaron Turpaz Silvia C Vega Roberto Visintainer Juergen von Frese Charles Wang Eric Wang Junwei Wang Wei Wang Frank Westermann James C Willey Matthew Woods Shujian Wu Nianqing Xiao Joshua Xu Lei Xu Lun Yang Xiao Zeng Jialu Zhang Li Zhang Min Zhang Chen Zhao Raj K Puri Uwe Scherf Weida Tong Russell D Wolfinger

Nat Biotechnol 2010 Aug 30;28(8):827-38. Epub 2010 Jul 30.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.

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http://dx.doi.org/10.1038/nbt.1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315840PMC
August 2010

Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice.

Authors:
Toni Gutierrez Kristina E Halcomb Alanna J Coughran Quan-Zhen Li Anne B Satterthwaite

Eur J Immunol 2010 Jul;40(7):1897-905

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/eji.200940043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057185PMC
July 2010

Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity.

Authors:
Nancy J Olsen Heidi Prather Quan-Zhen Li Dennis K Burns

Neuromuscul Disord 2010 Mar 27;20(3):188-91. Epub 2010 Jan 27.

Rheumatic Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8884, USA.

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http://dx.doi.org/10.1016/j.nmd.2009.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841214PMC
March 2010

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Authors:
Lei Guo Qiang Shi Stacey Dial Qingsu Xia Nan Mei Quan-zhen Li Po-Chuen Chan Peter Fu

Food Chem Toxicol 2010 Feb 3;48(2):686-96. Epub 2009 Dec 3.

Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.fct.2009.11.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918424PMC
February 2010

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.

Authors:
Marie-Laure Santiago-Raber Isabelle Dunand-Sauthier Tianfu Wu Quan-Zhen Li Satoshi Uematsu Shizuo Akira Walter Reith Chandra Mohan Brian L Kotzin Shozo Izui

J Autoimmun 2010 Jun 26;34(4):339-48. Epub 2009 Nov 26.

Department of Pathology and Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.

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June 2010

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.

Authors:
Kui Liu Quan-Zhen Li Angelica M Delgado-Vega Anna-Karin Abelson Elena Sánchez Jennifer A Kelly Li Li Yang Liu Jinchun Zhou Mei Yan Qiu Ye Shenxi Liu Chun Xie Xin J Zhou Sharon A Chung Bernardo Pons-Estel Torsten Witte Enrique de Ramón Sang-Cheol Bae Nadia Barizzone Gian Domenico Sebastiani Joan T Merrill Peter K Gregersen Gary G Gilkeson Robert P Kimberly Timothy J Vyse Il Kim Sandra D'Alfonso Javier Martin John B Harley Lindsey A Criswell Edward K Wakeland Marta E Alarcón-Riquelme Chandra Mohan

J Clin Invest 2009 Apr;119(4):911-23

Department of Immunology and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8884, USA.

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http://www.jci.org/articles/view/36728
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662554PMC
April 2009

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies.

Authors:
Leming Shi Wendell D Jones Roderick V Jensen Stephen C Harris Roger G Perkins Federico M Goodsaid Lei Guo Lisa J Croner Cecilie Boysen Hong Fang Feng Qian Shashi Amur Wenjun Bao Catalin C Barbacioru Vincent Bertholet Xiaoxi Megan Cao Tzu-Ming Chu Patrick J Collins Xiao-Hui Fan Felix W Frueh James C Fuscoe Xu Guo Jing Han Damir Herman Huixiao Hong Ernest S Kawasaki Quan-Zhen Li Yuling Luo Yunqing Ma Nan Mei Ron L Peterson Raj K Puri Richard Shippy Zhenqiang Su Yongming Andrew Sun Hongmei Sun Brett Thorn Yaron Turpaz Charles Wang Sue Jane Wang Janet A Warrington James C Willey Jie Wu Qian Xie Liang Zhang Lu Zhang Sheng Zhong Russell D Wolfinger Weida Tong

BMC Bioinformatics 2008 Aug 12;9 Suppl 9:S10. Epub 2008 Aug 12.

National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1186/1471-2105-9-S9-S10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2537561PMC
August 2008

Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

Authors:
Anna-Marie Fairhurst Sun-hee Hwang Andrew Wang Xiang-Hong Tian Christopher Boudreaux Xin J Zhou Jose Casco Quan-Zhen Li John E Connolly Edward K Wakeland

Eur J Immunol 2008 Jul;38(7):1971-8

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/eji.200838138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993003PMC
July 2008

Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.

Authors:
Anna-Marie Fairhurst Alexis Mathian John E Connolly Andrew Wang Hillery F Gray Tiffany A George Christopher D Boudreaux Xin J Zhou Quan-Zhen Li Sophie Koutouzov Jacques Banchereau Edward K Wakeland

Eur J Immunol 2008 Jul;38(7):1948-60

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/eji.200837925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699327PMC
July 2008