Publications by authors named "Qingyan Wang"

54 Publications

Magnetic resonance conditionality of abandoned leads from active implantable medical devices at 1.5 T.

Magn Reson Med 2021 Aug 11. Epub 2021 Aug 11.

Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA.

Purpose: During MR scans, abandoned leads from active implantable medical devices (AIMDs) can experience excessive heating at the lead tip, depending on the type of termination applied to the proximal contacts (proximal end treatment). The influence of different proximal end treatments (ie, [1] freely exposed in the tissue, [2] terminated with metal in contact with the tissue, or [3] capped with plastic, and thereby fully insulated, on the RF-induced lead-tip heating) are studied. A technique to ensure that MR Conditional AIMD leads remain MR Conditional even when abandoned is recommended.

Methods: Abandoned leads from three MR Conditional AIMDs ([1] a sacral neuromodulation system, [2] a cardiac rhythm management pacemaker system, and [3] a deep brain stimulator system) were investigated in this study. The computational lead models (ie, the transfer functions) for different proximal end treatments were measured and used to assess the in vivo lead-tip heating for four virtual human models (FATS, Duke, Ella, and Billie) and compared with the lead-tip heating of the complete MR Conditional AIMD system.

Result: The average and maximum lead-tip heating for abandoned leads proximally capped with metal is always lower than that from the complete AIMD system. Abandoned leads proximally insulated could lead to an average in vivo temperature rise up to 3.5 times higher than that from the complete AIMD system.

Conclusion: For the three investigated AIMDs under 1.5T MR scanning, our results indicate that RF-induced lead-tip heating of abandoned leads strongly depends on the proximal lead termination. A metallic cap applied to the proximal termination of the tested leads could significantly reduce the RF-induced lead-tip heating.
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http://dx.doi.org/10.1002/mrm.28967DOI Listing
August 2021

A technique for the reduction of RF-induced heating of active implantable medical devices during MRI.

Magn Reson Med 2021 Aug 10. Epub 2021 Aug 10.

Department of Electrical and Computer Engineering, University of Houston, Houston, Texas, USA.

Purpose: The paper presents a novel method to reduce the RF-induced heating of active implantable medical devices during MRI.

Methods: With the addition of an energy decoying and dissipating structure, RF energy can be redirected toward the dissipating rings through the decoying conductor. Three lead groups (45 cm-50 cm) and 4 (50 cm-100 cm) were studied in 1.5 Tesla MR systems by simulation and measurement, respectively. In vivo modeling was performed using human models to estimate the RF-induced heating of an active implantable medical device for spinal cord treatment.

Result: In the simulation study, it was shown that the peak 1g-averaged specific absorption rate near the lead-tips can be reduced by 70% to 80% compared to those from the control leads. In the experimental measurements during a 2-min exposure test in a 1.5 Telsa MR system, the temperature rises dropped from the original 18.3℃, 25.8℃, 8.1℃, and 16.1℃ (control leads 1-4) to 5.4℃, 6.9℃, 1.6℃, and 3.3℃ (leads 1-4 with the energy decoying and dissipation structure). The in vivo calculation results show that the maximum induced temperature rise among all cases can be substantially reduced (up to 80%) when the energy decoying and dissipating structures were used.

Conclusion: Our studies confirm the effectiveness of the novel technique for a variety of scanning scenarios. The results also indicate that the decoying conductor length, number of rings, and ring area must be carefully chosen and validated.
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http://dx.doi.org/10.1002/mrm.28953DOI Listing
August 2021

Review on strategies of close-to-natural wetland restoration and a brief case plan for a typical wetland in northern China.

Chemosphere 2021 Jul 13;285:131534. Epub 2021 Jul 13.

Beijing Engineering Research Center of Process Pollution Control, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

Wetlands play an important role in sustaining ecosystems on the earth, which regulate water resources, adjust local climate and produce food for human beings, etc. However, wetlands are facing huge challenges due to human activities and other natural evolution, such as area shrinkage, function weakening and biodiversity decrease, and so on, therefore, some wetlands need to be urgently restored. In this study, the main technology components of close-to-natural restoration of wetlands were summarized. The ecological water requirement and water resource allocation can be optimized for the water balance between social, economy and ecology, which is a key prerequisite for maintaining wetland ecosystem. The pollution of wetland sediments and soils can be assessed by various indicators to provide the scientific basis for natural restoration of wetland base, and suitable strategies should be taken according to the actual conditions of wetland bases. The hydrological connectivity in wetlands and with related water system can be numerically simulated to make the optimal plan for improvement of hydrological connectivity. The ecological restoration of wetlands with the synergetic function of plants, animals and microorganisms was summarized, to improve the quality of wetland water environment and maintain the ecosystem stability. Based on the wetland close-to-natural restoration strategies, a brief ecological restoration plan for a typical wetland, Zaozhadian Wetland, near Xiong'an New Area in the north China was proposed from water resource guarantee, base pollution management, hydrological connectivity improvement and biological restoration. The close-to-natural restoration shows more effective, sustainable and long-lasting and thus a practical prospect.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131534DOI Listing
July 2021

Prevalence and correlates of lifestyle behavior, anxiety and depression in Chinese college freshman: A cross-sectional survey.

Int J Nurs Sci 2021 Jul 5;8(3):347-353. Epub 2021 Jun 5.

Division of Humanity & Social Sciences, School of Nursing, Peking University, Beijing, China.

Objectives: First-year college students had exposure to unhealthy lifestyle behaviors that correlate with a high prevalence of anxiety and depression. Regarding to the modifiable lifestyle behaviors factors, this study investigated the prevalence and correlation of multiple lifestyle behaviors, anxiety and depression in a sample of Chinese first-year college students.

Methods: Cross-sectional data were extracted from app of health lifestyle behaviors survey from September to October 2019. Anxiety, depression, eating regular meals, consumption of snacks in-between meals, consumption of fruit, dessert and sugar-sweetened beverages, smoking and secondhand smoke exposure, consuming alcohol, physical activity, sedentary time were assessed by self-report. Socio-demographic including age, gender, education, family income, religion, and health condition were captured. Logistic regression was used to explore the association of multiple lifestyle behaviors, anxiety and depression.

Results: Totally 1,017 participants were included in the study. The prevalence of anxiety and depression (from mild to severe) were 40.3% and 45.3%, respectively. In multivariable analyses, religion (believe in Buddhism,  = 2.438, 95%CI: 1.097-5.421; believe in Christian,  = 5.886, 95%CI: 1.604-21.597), gender (Female,  = 1.405, 95%CI: 1.001-1.971), secondhand smoke exposure ( = 1.089, 95%CI: 1.001-1.184), and eating regular meals ( = 0.513, 95%CI: 0.346-0.759) were associated with anxiety. Family income ( = 0.732, 95%CI: 0.596-0.898), eating regular meals ( = 0.641, 95%CI: 0.415-0.990), frequency of breakfast ( = 0.813, 95%CI: 0.690-0.959), with a chronic disease ( = 1.902, 95%CI: 1.335-2.712), and consumption of nocturnal snack ( = 1.337, 95%CI: 1.108-1.612) were associated with depression.

Conclusions: These results highlighted the need for early lifestyle behavior intervention, especially modifying diet patterns considering the background of religion, health condition, and social-economic status in first-year college students to improve their mental health.
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http://dx.doi.org/10.1016/j.ijnss.2021.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283720PMC
July 2021

How physicians respond to negative emotions in high-risk preoperative conversations.

Patient Educ Couns 2021 Jul 9. Epub 2021 Jul 9.

The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate physicians' responses to negative emotions in high-risk preoperative conversations; and to explore the influencing factors of these responses.

Methods: One hundred and sixty-two audio recordings were coded using the Chinese Verona Coding Definition of Emotional Sequences (VR-CoDES). Big Five Personality Inventory Brief Version and Emotional Intelligence Scale were administered to explore the influencing factors of physicians' responses. SPSS 24.0 and R 3.6.3 LME4 Package were used for data analysis.

Results: Reduce Space (83%), referring to physicians' responses reducing the opportunities of patients to disclose emotions, was physicians' most frequent response to patients or families' emotions. The main responses were Information-advice (ERIa) and Ignoring (NRIa). Younger age, female, Agreeableness and Openness were factors positively associated with Explicit Provide Space (EP); Neuroticism was negatively correlated with EP. Extroversion was negatively correlated with Explicit Reduce Space (ER); Conscientiousness was negatively correlated with both EP and ER responses. Emotional intelligence had no significant influence on physicians' responses.

Conclusion: The majority of physicians were inclined to reduce space by providing information advice or ignoring. Physicians' responses were correlated with their gender, age and personality traits.

Practice Implications: The trainees' gender, age and personality should be considered when conducting doctor-patient communication skills training.
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http://dx.doi.org/10.1016/j.pec.2021.06.022DOI Listing
July 2021

Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.

Ren Fail 2021 Dec;43(1):1028-1040

Department of General Surgery, The First Affiliated Hospital, Xi'an Medical University, Xi'an, China.

Sepsis-induced acute kidney injury (AKI) continues to be associated with poor outcomes in critical care patients. Previous research has revealed that tetrahydrocurcumin (THC) exerts renoprotective effects in multiple nephritic disorders by modulating inflammation and oxidative stress. However, the effects of THC on sepsis-induced AKI and the underlying mechanisms remain unclear. In this study, a mouse model of sepsis-induced AKI, generated by cecal ligation and puncture operation, was used to investigate the protective effects of THC and the role of SIRT1. Histological manifestation and TUNEL analysis were observed to determine the severity of kidney damage. Levels of BUN, SCr, KIM-1, and UAlb/Cr were calculated to assess the renal function. Expressions of IL-1β, IL-6, and TNF-α were measured to evaluate the inflammatory response. MDA content, SOD, GSH, CAT, and GPx activities and DHE staining were analyzed to estimate the degree of oxidative stress. Protein expressions of SIRT1, Ac-p65, and Ac-foxo1 were detected to explore the underlying mechanisms. We observed that THC not only increased the survival rate, improved the kidney function and ameliorated the renal histological damage of septic mice, but also inhibited inflammatory response, prohibited oxidative stress, and prevented cell apoptosis in renal tissues in septic mice. Mechanistically, THC remarkably increased the expression of SIRT1, accompanied by decreased expressions of downstream molecules Ac-p65 and Ac-foxo1. Meanwhile, the beneficial effects of THC were clearly abolished by the SIRT1-specific inhibitor EX527. These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling. Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1β: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-α: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine.
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http://dx.doi.org/10.1080/0886022X.2021.1942915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253188PMC
December 2021

The Chinese version of OPTION scale: Is it reliable on measuring the shared decision-making among preoperative conversations.

Patient Educ Couns 2021 Apr 21. Epub 2021 Apr 21.

The Third Xiangya Hospital of Central South University, Department of Clinical Psychology, Changsha, China.

Objective: To test the reliability of the Chinese version of the OPTION (OPTION-C) scale; and to evaluate the level of shared decision-making (SDM) in the preoperative conversations for high-risk procedures by using the OPTION-C.

Methods: Two hundred and ninety-seven conversations were rated. Cronbach's alpha, Pearson's correlation coefficient and intraclass correlation coefficient (ICC) were used to assess the reliability of the OPTION-C. Mean and median were applied to evaluate the scores.

Results: The Cronbach's alpha was 0.603. The Pearson's correlation coefficient of the sub-items ranged from 0.002 to 0.595; the inter-rater ICC was 0.992. The mean and median of the total scores were 9.61 ( ± 3.583) and 9 respectively. 430 family members appeared in the conversations.

Conclusion: The reliability of the OPTION-C was acceptable. The SDM behaviors of doctors were only scored at or close to the minimal skill level. High level of family involvement demonstrated the Chinese culture of family- centeredness.

Practice Implications: The OPTION-C was proved to be applicable for testing the extent of SDM. The low level of SDM indicates a need to improve Chinese doctors' communication skills.
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http://dx.doi.org/10.1016/j.pec.2021.04.012DOI Listing
April 2021

Spectroscopic evidence of superconductivity pairing at 83 K in single-layer FeSe/SrTiO films.

Nat Commun 2021 May 14;12(1):2840. Epub 2021 May 14.

National Lab for Superconductivity, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.

Single-layer FeSe films grown on the SrTiO substrate (FeSe/STO) have attracted much attention because of their possible record-high superconducting critical temperature (T) and distinct electronic structures. However, it has been under debate on how high its T can really reach due to the inconsistency of the results from different measurements. Here we report spectroscopic evidence of superconductivity pairing at 83 K in single-layer FeSe/STO films. By preparing high-quality single-layer FeSe/STO films, we observe strong superconductivity-induced Bogoliubov back-bending bands that extend to rather high binding energy ~ 100 meV by high-resolution angle-resolved photoemission measurements. They provide a new definitive benchmark of superconductivity pairing that is directly observed up to 83 K. Moreover, we find that the pairing state can be further divided into two temperature regions. These results indicate that either T as high as 83 K is achievable, or there is a pseudogap formation from superconductivity fluctuation in single-layer FeSe/STO films.
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http://dx.doi.org/10.1038/s41467-021-23106-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121788PMC
May 2021

The effects of CPBL + SBAR teaching mode among the nursing students.

Nurse Educ Today 2021 May 1;100:104828. Epub 2021 Mar 1.

Department of Nephrology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China. Electronic address:

Objective: To investigate the effect of CPBL (Problem Based Learning on Case) combined with SBAR (Situation, Background, Assessment and Recommendation) mode in clinical teaching for nursing students.

Background: Clinical internship training is the key step for the nursing education. The clinical thinking ability of Chinese nurses is mostly at the middle or low level. To improve clinical thinking ability, especially critical thinking, is of great significance to the nursing practice education.

Methods: 102 nursing students of the Third Xiangya Hospital, Central South University were selected as the participants from June 2018 to September 2019. We applied the CPBL + SBAR mode to the participants during the practice teaching, and conducted questionnaires and semi-structured interview pre- and post-intervention.

Results: After intervention, the nursing students' scores of critical thinking ability (311.47 ± 22.67) were higher than those before intervention (289.75 ± 19.94); the total score (69.84 ± 6.217) and scores in four dimensions of positive problem orientation (RPO), negative problem orientation (NPO), avoidance style (AS) and impulse neglect style (ICS) were all lower than that before intervention (75.53 ± 6.09); the score of rational problem solving (RPS) (18.38 ± 2.714) was higher comparing to the that of pre-intervention (17.11 ± 2.20); the difference was statistically significant (P < 0.05). The approval rate of nursing students to the positive effect of CPBL + SBAR teaching mode was from 78.43% to 93.13%. The semi-structured interview suggested that the model was worth promoting, but the implementation duration was limited.

Conclusion: CPBL + SBAR teaching mode could improve the nursing students' critical thinking and problem-solving ability. The nursing students and teachers' satisfaction to the new teaching mode was high.
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http://dx.doi.org/10.1016/j.nedt.2021.104828DOI Listing
May 2021

Effect of substrate load on anaerobic fermentation of rice straw with rumen liquid as inoculum: Hydrolysis and acidogenesis efficiency, enzymatic activities and rumen bacterial community structure.

Waste Manag 2021 Apr 23;124:235-243. Epub 2021 Feb 23.

College of Environmental Science & Engineering, Beijing Forestry University, Beijing 100083, China.

Rumen liquid is excellent to effectively degrade lignocellulose. In this study, the suitable rice straw load during anaerobic fermentation of rice straw with rumen liquid as inoculum was explored to improve volatile fatty acid (VFA) production. At 10.0% rice straw load, the highest VFA concentration reached 10821.4 mg/L, and acetic acid and propionic acid were the main components. In 10.0% rice straw load system, high concentration of soluble chemical oxygen demand (SCOD) was also observed, and the enzymatic activities at 48 h were higher than those at other rice straw loads. At 10.0% rice straw load, lower diversity and richness of rumen bacteria were found than those at other rice straw loads. Bacteroides, Prevotella, and Ruminococcus were the main rumen bacteria during rice straw degradation, and the rumen bacteria might secret effective lignocellulolytic enzymes to enhance the hydrolysis and acidogenesis of rice straw. The determination of suitable rice straw load will be beneficial to the application of rumen liquid as inoculum in actual production.
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http://dx.doi.org/10.1016/j.wasman.2021.02.017DOI Listing
April 2021

Transformation of bacterial community structure in rumen liquid anaerobic digestion of rice straw.

Environ Pollut 2021 Jan 21;269:116130. Epub 2020 Nov 21.

College of Environmental Science & Engineering, Beijing Forestry University, Beijing, 100083, China.

Rumen liquid can effectively degrade lignocellulosic biomass, in which rumen microorganisms play an important role. In this study, transformation of bacterial community structure in rumen liquid anaerobic digestion of rice straw was explored. Results showed that rice straw was efficiently hydrolyzed and acidified, and the degradation efficiency of cellulose, hemicellulose and lignin reached 46.2%, 60.4%, and 12.9%, respectively. The concentration of soluble chemical oxygen demand (SCOD) and total volatile fatty acid (VFA) reached 12.9 and 8.04 g L. The high-throughput sequencing results showed that structure of rumen bacterial community significantly changed in anaerobic digestion. The Shannon diversity index showed that rumen bacterial diversity decreased by 32.8% on the 5th day of anaerobic digestion. The relative abundance of Prevotella and Fibrobacter significantly increased, while Ruminococcus significantly decreased at the genus level. The Spearman correlation heatmap showed that pH and VFA were the critical factors affecting the rumen bacterial community structure. The function prediction found that rumen bacteria mainly functioned in carbohydrate transport and metabolism, which might contain a large number of lignocellulose degrading enzyme genes. These studies are conducive to the better application of rumen microorganisms in the degradation of lignocellulosic biomass.
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http://dx.doi.org/10.1016/j.envpol.2020.116130DOI Listing
January 2021

A counterpoise design for RF-induced heating reduction.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:4200-4203

This paper presents a novel lead body design for active implantable medical devices (AIMD) to reduce Radio-frequency (RF) induced heating during magnetic resonance imaging (MRI) scanning. By introducing a counterpoise electrode to the original lead construct, part of the RF-induced energy can be decoyed into the surrounding tissues while the therapy signal is intact. The numerical simulation studies of three leads with different configurations are presented to demonstrate the effectiveness of this technique. From simulation results at 1.5 T, the peak 1g average SAR value can be reduced by a factor of 3 when the length of the counterpoise electrode is properly designed.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175891DOI Listing
July 2020

Power production waste.

Water Environ Res 2020 Oct 28;92(10):1711-1716. Epub 2020 Aug 28.

College of Environmental Science & Engineering, Beijing Forestry University, Beijing, China.

The storage of large amount of power production waste occupies huge land resource; moreover, the stored or discarded waste may pollute the water environment through changing the water pH, releasing the trace and toxic elements even radioactive elements, and so on by leachate. Therefore, the recycling and disposal of power production waste are important and necessary. This paper reviews the research literatures published in 2019 on power generation waste from coal-fired and nuclear power plants, mainly including the recycling of fly ash and flue gas desulfurization gypsum in construction industry and environmental application, the recovery and immobilization of different metals from coal combustion products and selective catalytic reduction catalysts, and the treatment and disposal of radioactive elements from nuclear power plants. Practioner points Coal-fired power plant waste can be applied for material preparation and wastewater purification. Valued and toxic metals are normally recovered or removed from spent selective catalytic reduction catalyst. Recovery and removal of radioactive elements is essential for nuclear power plant wastes disposal.
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http://dx.doi.org/10.1002/wer.1426DOI Listing
October 2020

Transcription Analysis of Recombinant HJ-48 to Compare the Molecular Basis for Fermentation of Glucose and Xylose.

J Microbiol Biotechnol 2020 Oct;30(10):1467-1479

National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Key Laboratory of Biorefinery, Guangxi Biomass Engineering Technology Research Center, Guangxi Academy of Sciences, Nanning 530007, P.R. China.

Profiling the transcriptome changes involved in xylose metabolism by the fungus allows for the identification of potential targets for ethanol production processing. In the present study, the transcriptome of HJ-48 grown on xylose versus glucose was analyzed using nextgeneration sequencing technology. During xylose fermentation, numerous genes related to central metabolic pathways, including xylose reductase (XR) and xylitol dehydrogenase (XDH), were expressed at higher levels in HJ-48. Notably, growth on xylose did not fully repress the genes encoding enzymes of the tricarboxylic acid and respiratory pathways. In addition, increased expression of several sugar transporters was observed during xylose fermentation. This study provides a valuable dataset for further investigation of xylose fermentation and provides a deeper insight into the various genes involved in this process.
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http://dx.doi.org/10.4014/jmb.2004.04007DOI Listing
October 2020

Development of an Innovative Process for High-Temperature Fruit Juice Extraction Using a Novel Thermophilic Endo-Polygalacturonase From .

Front Microbiol 2020 12;11:1200. Epub 2020 Jun 12.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, China.

Efficient and cost-effective production of thermophilic endo-polygalacturonase is desirable for industrial fruit juice production, because its application could shorten the processing time and lower the production cost, by eliminating the separate step of pectin degradation. However, no endo-polygalacturonase that both functions well at sufficiently high temperature and can be manufactured economically, has been reported previously. In this study, the cDNA encoding a thermophilic endo-polygalacturonase from CZ1028, was cloned and over-expressed in GS115 and BL21(DE3). The recombinant proteins PoxaEnPG28B-Pp (from ) and PoxaEnPG28B-Ec (from ) were isolated and purified. PoxaEnPG28B-Pp was sufficiently thermostable for potential industrial use, but PoxaEnPG28B-Ec was not. The optimal pH and temperature of PoxaEnPG28B-Pp were pH 5.0 and 65°C, respectively. The enzyme had a low of 1.82 g/L and a high of 77882.2 U/mg, with polygalacturonic acid (PGA) as substrate. The performance of PoxaEnPG28B-Pp in depectinization of papaya, plantain and banana juices at 65°C for 15 min was superior to that of a reported mesophilic endo-polygalacturonase. PoxaEnPG28B-Pp is the first endo-polygalacturonase reported to show excellent performance at high temperature. An innovative process, including a step of simultaneous heat-treatment and depectinization of fruit pulps with PoxaEnPG28B-Pp, is reported for the first time.
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http://dx.doi.org/10.3389/fmicb.2020.01200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303257PMC
June 2020

Reducing MRI RF-induced heating for the external fixation using capacitive structures.

Phys Med Biol 2020 08 11;65(15):155017. Epub 2020 Aug 11.

Dept. of Electrical and Computer Engineering, University of Houston, Houston, TX, 77204-4005, United States of America.

This paper presents a generic method to reduce the radiofrequency (RF) induced heating of external fixation devices during the magnetic resonance imaging (MRI) procedure. A simplified equivalent circuit model was developed to illustrate the interaction between the external fixation device and the MRI RF field. Carefully designed mechanical structures, which utilize capacitive reactance from the circuit model, were applied to the external fixation device to mitigate the coupling between the external fixation device and the MRI RF field for RF-induced heating reduction. Both numerical and experimental studies were performed to demonstrate the validity of the circuit model and the effectiveness of the proposed method. By adding capacitive structures in both the clamp-pin and rod-clamp joints, the peak specific absorption rate averaged in 1 gram (SAR) near the pin tips were reduced from 760.4 W kg to 12.0 W kg at 1.5 T and 391.5 W kg to 25.2 W kg at 3 T from numerical simulations. Experimental results showed that RF-induced heating was reduced from 7.85 °C to 1.01 °C at 1.5 T and from 16.70 °C to 0.32 °C at 3 T for the external fixation device studied here. The carefully designed capacitive structures can be used to detune the coupling between the external fixation device and the MRI fields to reduce the RF-induced heating in the human body for both 1.5 T and 3 T MRI systems. However, as RF-induced heating is very device and design specific all devices must be thoroughly tested based on its final design.
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http://dx.doi.org/10.1088/1361-6560/ab9706DOI Listing
August 2020

Thermal effects.

Water Environ Res 2020 Oct 1;92(10):1406-1411. Epub 2020 May 1.

College of Environmental Science & Engineering, Beijing Forestry University, Beijing, China.

This review paper focuses on the researches published in 2019 in the field of thermal effects in wastewater and solid waste treatment. The content of this review paper includes five parts: wastewater and sludge treatment, nutrient removal and recovery, membrane technology, heavy metal removal and immobilization, and organic waste utilization. © 2020 Water Environment Federation PRACTITIONER POINTS: Thermal effect plays an important role in treatment of wastewater and sewage sludge. Recovery of nitrogen and phosphorus from wastewater and sewage sludge reduces environmental pollution and offers new products. Temperature improves removal and recovery of heavy metals and organic wastes.
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http://dx.doi.org/10.1002/wer.1337DOI Listing
October 2020

Chain elongation performances with anaerobic fermentation liquid from sewage sludge with high total solid as electron acceptor.

Bioresour Technol 2020 Mar 14;306:123188. Epub 2020 Mar 14.

College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China.

This work studied the effect of total solid (TS) of sewage sludge on VFA production and composition in anaerobic fermentation. Results revealed that VFA concentration reached the highest of 10.16 g/L and the ratio of acetic acid, propionic acid and n-butyric acid was 5:2:2 with the 8% TS sewage sludge. In subsequent chain elongation with sludge fermentation liquid, n-caproic acid concentration reached 43.45 mmol/L. The microbial community analysis indicated that relative abundance of Clostridium_sensu_stricto_12 for n-caproic acid production was high (52.41%). The chain elongation with sludge fermentation liquid had more pathways to produce n-caproic acid, and the chain elongation reactions were thermodynamically possible. The mixed VFAs and high concentration of n-butyric acid benefitted n-caproic acid production. Carbon balance revealed that the VFA composition of sludge fermentation liquid was beneficial to the chain elongation. This study will contribute to wasted sludge minimization and high-value material production.
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http://dx.doi.org/10.1016/j.biortech.2020.123188DOI Listing
March 2020

Green synthesis of garlic oil nanoemulsion using ultrasonication technique and its mechanism of antifungal action against Penicillium italicum.

Ultrason Sonochem 2020 Jun 11;64:104970. Epub 2020 Jan 11.

Beijing Research Center of Intelligent Equipment for Agriculture, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China; National Research Center of Intelligent Equipment for Agriculture, Beijing 100097, China; Key Laboratory of Agri-informatics, Ministry of Agriculture, Beijing 100097, China; Beijing Key Laboratory of Intelligent Equipment Technology for Agriculture, Beijing 100097, China.

Penicillium italicum (P. italicum) can cause significant economic loss of fruits and vegetables. Although garlic oil (GO) is an effective antimicrobial agent, the unstability and hydrophobicity limit its use as an environmentally friendly alternative to the conventional antibiotics against P. italicum. In this study, we focused on the fabrication and characterization of a functional GO nanoemulsion (NE) using ultrasonic technique and revealed the antifungal mechanism of the GO NE on P. italicum based on morphological, structural and molecular analyses. The optimal hydrophilic lipophilic balance (HLB) value determined for GO was 14 through the combination of Tween 80 and Span 80. Then the Box-Benhnken Design (BBD) was applied to produce the GO NE and the effects of different fabrication parameters on the particle size were evaluated. The optimal GO NE was selected with the GO concentration of 5.5%, the Smix concentration of 10%, the ultrasonic time of 5 min and the power of 50%. This GO NE had the smallest particle size of 52.27 nm, the best antifungal effect and the most stability. Furthermore, the antifungal mechanism of the GO NE on P. italicum was evaluated by extracellular conductivity, micro-Raman spectra, fluorescence imaging and scanning electron microscopy (SEM) imaging. The results presented that the GO NE retained the antifungal active ingredients. The fungal cell structure and morphology were malformed after treated with the GO NE and the lipids, nucleic acids and protein of P. italicum were destructed. Finally, the optimal GO NE was applied in vivo and P. italicum in citrus was successfully inhibited. It indicated that the optimal GO NE had the better antifungal activity against P. italicum than the pure GO. Besides, the minimum inhibitory concentration (MIC) of GO after preparing into the NE was changed from 3.7% to 0.01265% with about 300 times improvement of bioavailability. Therefore, the synthetic GO NE which promoted the bioavailability of GO was recommended as a promising alternative to inhibit P. italicum in vegetables and fruits.
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http://dx.doi.org/10.1016/j.ultsonch.2020.104970DOI Listing
June 2020

Anomalous quantum Griffiths singularity in ultrathin crystalline lead films.

Nat Commun 2019 Aug 12;10(1):3633. Epub 2019 Aug 12.

International Center for Quantum Materials, School of Physics, Peking University, 100871, Beijing, China.

Superconductor-insulator/metal transition (SIT/SMT) represents a prototype of quantum phase transition, where quantum fluctuation plays a dominant role and dramatically changes the physical properties of low-dimensional superconducting systems. Recent observation of quantum Griffiths singularity (QGS) offers an essential perspective to understand the subtleties of quantum phase transition in two-dimensional superconductors. Here we study the magnetic field induced SMT in ultrathin crystalline Pb films down to ultralow temperatures. The divergent critical exponent is observed when approaching zero temperature quantum critical point, indicating QGS. Distinctively, the anomalous phase boundary of SMT that the onset critical field decreases with decreasing temperatures in low temperature regime distinguishes our observation from previous reports of QGS in various two-dimensional superconductors. We demonstrate that the anomalous phase boundary originates from the superconducting fluctuations in ultrathin Pb films with pronounced spin-orbit interaction. Our findings reveal a novel aspect of QGS of SMT in two-dimensional superconductors with anomalous phase boundary.
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http://dx.doi.org/10.1038/s41467-019-11607-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690870PMC
August 2019

Isolation and Characterization of a Novel Bacterium Bsp-1 Producing Alkaline Lipase.

J Microbiol Biotechnol 2019 Jul;29(7):1043-1052

National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Key Laboratory of Bio-refinery, Guangxi Biomass EngineeringTechnology Research Center, Guangxi Academy of Sciences, Nanning 530007, P.R. China.

Active lipase-producing bacterium Bps-1 was rapidly isolated using a modified trypan blue and tetracycline, ampicillin (TB-TA) plate. The electro-phoretically pure enzyme was obtained by purification using ethanol precipitation, ion-exchange chromatography, and gel filtration chromatography. The molecular weight was 34.6 kDa and the specific activity was determined to be 443.9 U/mg. The purified lipase showed the highest activity after hydrolysis with p-NPC at a pH of 8.5 and 50°C, and the , , and / values were 1.05, 292.95 s and 279 smM, respectively. The lipase was highly stable at 7.5 ≤ pH ≤ 10.0. K and Na exerted activation effects on the lipase which had favorable tolerance to short-chain alcohols with its residual enzyme activity being 110% after being maintained in 30% ethanol for 1 h. The results demonstrated that the lipase produced by the strain Bps-1 has high enzyme activity and is an alkaline lipase. The lipase has promising chemical properties for a range of applications in the food-processing and detergent industries, and has particularly high potential for use in the manufacture of biodiesel.
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http://dx.doi.org/10.4014/jmb.1903.03045DOI Listing
July 2019

Computational and experimental investigation of RF-induced heating for multiple orthopedic implants.

Magn Reson Med 2019 11 10;82(5):1848-1858. Epub 2019 Jun 10.

Department of Electrical and Computer Engineering, University of Houston, Houston, Texas.

Purpose: This paper investigates the RF-induced heating for multiple adjacent orthopedic implants under MRI at 1.5T and 3T exposure. When multiple implants are closely spaced to each other, the interactions between the implants may affect the RF-induced heating. Traditional RF-induced heating labeling is often only applicable to configurations of an individual implant, and is not applicable for multi-implant configurations. Therefore, the aim of this study is to evaluate the effects of multiple orthopedic implants on RF-induced heating and to propose potential appropriate instructions for safe scanning of multi-implantable orthopedic implants.

Methods: Typical plate and nail implants were used as examples. The effects of implant configuration, relative positions, and number of implants were investigated. Numerical simulations were conducted using full-wave electromagnetic simulation software. Experimental measurements at 1.5 T were performed to validate the numerical results.

Results: Numerical results indicate that, due to device interaction, the RF-induced heating of multiple medical implants can be significantly different from that of a single implant. The measured temperature rise for multiple devices could be 2.7 times larger than that of a single implant.

Conclusion: Our results confirm that RF-induced heating of multiple implants can be quite different, and do not follow simple superposition of the results from single devices. Instructions for safe scanning of individual orthopedic devices would not be applicable to multi-implant configurations.
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http://dx.doi.org/10.1002/mrm.27817DOI Listing
November 2019

Effect of Different Sources Support on Adaptation in Families of Patient With Moderate-to-Severe Dementia in China.

Am J Alzheimers Dis Other Demen 2019 09 29;34(6):361-375. Epub 2019 May 29.

1 Department of Fundamental Nursing, School of Nursing, Peking Union Medical College, Beijing, China.

Purpose: To examine the support from different sources of Chinese families of patients with moderate-to-severe dementia that most heavily influences the family adaptation and the influence pathway.

Method: Two hundred and three families participated in this study. Chinese versions of instruments were used. Structural equation modeling was applied to confirm the effect pathway.

Results: More family support, kin support, community support, and social support (narrow sense) were related to greater levels of family adaptation. Family support was the most heavy influence factor (total effect = 0.374), followed by kin support (0.334), social support (0.137), and community support (0.121). Family support and kin support were direct influence factors, while the other 2 were not.

Conclusion: All support will promote family adaptation, especially family support and kin support. Interventions improving support from different sources, especially family support and kin support, will promote adaptation in Chinese families of patients with moderate-to-severe dementia.
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http://dx.doi.org/10.1177/1533317519855154DOI Listing
September 2019

Detection of Bosonic Mode as a Signature of Magnetic Excitation in One-Unit-Cell FeSe on SrTiO.

Nano Lett 2019 06 23;19(6):3464-3472. Epub 2019 May 23.

International Center for Quantum Materials, School of Physics , Peking University , Beijing 100871 , China.

A "fingerprint" of Cooper pairing mediated by collective bosonic excitation mode is the reconstruction of the quasiparticle-density-of-states (DOS) spectrum with an additional "dip-hump" structure located outside the superconducting coherence peak. Here, we report an in situ scanning tunneling spectroscopy study of one-unit-cell (1-UC) FeSe film on a SrTiO(001) substrate. In the quasiparticle-DOS spectrum, the bosonic excitation mode characterized by the dip-hump structure is detected outside the larger superconducting gap. Statistically, the excitation mode shows an anticorrelation with pairing strength in magnitude and yields an energy scale upper-bounded by twice the superconducting gap. The observation coincides with the characteristics of magnetic resonance in cuprates and iron-based superconductors. Furthermore, the local response of superconducting spectra to magnetically distinct Se defects all exhibits the induced in-gap quasiparticle bound states, indicating an unconventional sign-reversing pairing over the Fermi surface in 1-UC FeSe. These results clarify the magnetic nature of the bosonic excitation mode and reveal a signature of electron-magnetic-excitation coupling in 1-UC FeSe/SrTiO(001) besides the previously established pairing channel of electron-phonon interaction.
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http://dx.doi.org/10.1021/acs.nanolett.9b00144DOI Listing
June 2019

On the development of equivalent medium for active implantable device radiofrequency safety assessment.

Magn Reson Med 2019 09 17;82(3):1164-1176. Epub 2019 May 17.

Department of Electrical and Computer Engineering, University of Houston, Houston, Texas.

Purpose: To develop the equivalent medium theorem that can be used to perform accurate evaluation of implantable device safety under MRI exposure.

Methods: Numerical methods were used to determine the equivalent medium parameters along clinically relevant trajectories inside a human body model. Additionally, numerical and experimental investigations were performed using both a computational human body model and an inhomogeneous phantom to demonstrate the effectiveness of the method.

Results: The equivalent medium parameters, which are determined from a simplified lead configuration, are independent of the lead types and lead design parameters and only depend on the lead trajectories. Experimental investigations using an inhomogeneous phantom showed excellent agreement between the computational predicted values and the direct measured temperature rises indicating the effectiveness and accuracy of this method.

Conclusion: For the models based on multiple patient trajectories studied, it demonstrates that the equivalent medium theorem is valid for leads of different types and designs, as long as the lead trajectories are determined.
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http://dx.doi.org/10.1002/mrm.27785DOI Listing
September 2019

Can Verona Coding Definitions of Emotional Sequences (VR-CoDES) be applied to standardized Chinese medical consultations? - A reliability and validity investigation.

Patient Educ Couns 2019 08 5;102(8):1460-1466. Epub 2019 Apr 5.

Third Xiangya Hospital of Central South University, Department of Psychology, 138 Tong Zi Po road, Changsha, United States. Electronic address:

Objective: To investigate the reliability and validity of the Chinese version of VR-CoDES.

Methods: The VR-CoDES was translated into Chinese, and a focus group was held to discuss its cultural adaptation. Video consultations between 75 fourth-year medical students and 2 standardized patients (SPs) were coded by two raters with the Chinese VR-CoDES. Inter-rater reliability was tested by using ICC. To obtain validity, the SPs reviewed the video consultations to confirm the cues and concerns.

Results: ICC was 0.79. Specificity and sensitivity were 0.99 and 0.96 respectively. The SPs expressed considerably more cues (mean = 7.00) than concerns (mean = 0.32). Half of the responses of medical students were explicit reducing space. Focus group participants raised some cultural considerations, and some interactions were difficult to code due to cultural differences.

Conclusion: The Chinese VR-CoDES obtained good reliability and validity. Due to differences in the expression of emotions and other differences such as different medical systems between China and Western countries, the Chinese VR-CoDES needs further cultural adaptation.

Practice Implication: More consultations in real clinical settings need to be gathered to further support the Chinese VR-CoDES both on validation and cultural adaptation.
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http://dx.doi.org/10.1016/j.pec.2019.03.025DOI Listing
August 2019

Quantitative assessment of zearalenone in maize using multivariate algorithms coupled to Raman spectroscopy.

Food Chem 2019 Jul 14;286:282-288. Epub 2019 Feb 14.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; Sino-British Joint Laboratory of Food Nondestructive Detection, Zhenjiang 212013, China.

Zearalenone is a contaminant in food and feed products which are hazardous to humans and animals. This study explored the feasibility of the Raman rapid screening technique for zearalenone in contaminated maize. For representative Raman spectra acquisition, the ground maize samples were collected by extended sample area to avoid the adverse effect of heterogeneous component. Regression models were built with partial least squares (PLS) and compared with those built with other variable selection algorithms such as synergy interval PLS (siPLS), ant colony optimization PLS (ACO-PLS) and siPLS-ACO. SiPLS-ACO algorithm was superior to others in terms of predictive power performance for zearalenone analysis. The best model based on siPLS-ACO achieved coefficients of correlation (R) of 0.9260 and RMSEP of 87.9132 μg/kg in the prediction set, respectively. Raman spectroscopy combined multivariate calibration showed promising results for the rapid screening large numbers of zearalenone maize contaminations in bulk quantities without sample-extraction steps.
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http://dx.doi.org/10.1016/j.foodchem.2019.02.020DOI Listing
July 2019

[In vivo synthesis of csypyrone derivatives by exploring the substrate diversity of start units of type Ⅲ polyketide synthase CsyB].

Sheng Wu Gong Cheng Xue Bao 2018 Jul;34(7):1137-1146

Guangxi Key Laboratory of Biorefinery, Guangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.

As a novel fungal type Ⅲ polyketide synthase, CsyB from Aspergillus oryzae can sequentially accept one molecular short chain fatty acyl CoA as start unit, one molecular malonyl-CoA and one molecular acetoacetyl-CoA as extend unit to produce the short chain csypyrone B1-3. On the basis of crystal structure of CsyB, a fatty acyl CoA binding tunnel of a length of about 16 Å is located in its active center that is proposed to accept diversified start units. In order to examine the substrate diversity of CsyB, CsyB gene was introduced and expressed in Escherichia coli that contained a number of precursors of long chain fatty acyl CoA in vivo. The results of HPLC revealed that a series of long chain csypyrone derivatives were detected in the recombinant strain in comparison with the control strain. These new csypyrone compounds were preliminarily analyzed by UV-visible spectroscopy and LC-HRMS. Three hydroxylated csypyrones were intensively determined by 1D and 2D NMR experiments, especially the position of the hydroxyl group in these compounds. These results demonstrate that CsyB exhibits a broad substrate specificity, which not only can accept the long chain saturated or unsaturated fatty acyl CoA as substrate, but also accept hydroxylated long chain fatty acyl CoA.
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http://dx.doi.org/10.13345/j.cjb.170426DOI Listing
July 2018

Rapid and visual detection of the main chemical compositions in maize seeds based on Raman hyperspectral imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Jul 13;200:186-194. Epub 2018 Apr 13.

Beijing Research Center of Intelligent Equipment for Agriculture, Beijing 100097, China; National Research Center of Intelligent Equipment for Agriculture, Beijing 100097, China; Key Laboratory of Agri-informatics, Ministry of Agriculture, Beijing 100097, China; Beijing Key Laboratory of Intelligent Equipment Technology for Agriculture, Beijing 100097, China.

Rapid and visual detection of the chemical compositions of plant seeds is important but difficult for a traditional seed quality analysis system. In this study, a custom-designed line-scan Raman hyperspectral imaging system was applied for detecting and displaying the main chemical compositions in a heterogeneous maize seed. Raman hyperspectral images collected from the endosperm and embryo of maize seed were acquired and preprocessed by Savitzky-Golay (SG) filter and adaptive iteratively reweighted Penalized Least Squares (airPLS). Three varieties of maize seeds were analyzed, and the characteristics of the spectral and spatial information were extracted from each hyperspectral image. The Raman characteristic peaks, identified at 477, 1443, 1522, 1596 and 1654 cm from 380 to 1800 cm Raman spectra, were related to corn starch, mixture of oil and starch, zeaxanthin, lignin and oil in maize seeds, respectively. Each single-band image corresponding to the characteristic band characterized the spatial distribution of the chemical composition in a seed successfully. The embryo was distinguished from the endosperm by band operation of the single-band images at 477, 1443, and 1596 cm for each variety. Results showed that Raman hyperspectral imaging system could be used for on-line quality control of maize seeds based on the rapid and visual detection of the chemical compositions in maize seeds.
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http://dx.doi.org/10.1016/j.saa.2018.04.026DOI Listing
July 2018

Efficient production of succinic acid from duckweed (Landoltia punctata) hydrolysate by Actinobacillus succinogenes GXAS137.

Bioresour Technol 2018 Feb 4;250:35-42. Epub 2017 Oct 4.

National Non-grain Bio-energy Engineering Research Center, Guangxi Academy of Sciences, Nanning, Guangxi 530007, China.

A novel process of enzyme pretreatment and semi-simultaneous saccharification and fermentation (SSSF) was developed in this work to improve succinic acid (SA) productivity from duckweed (Landoltia punctata) and achieve low viscosity. Viscosity (83.86%) was reduced by the pretreatment with combined enzymes at 50 °C for 2 h to a greater extent than that by single enzyme (26.19-71.75%). SSSF was an optimal combination with 65.31 g/L of SA content, which was remarkably higher than those obtained through conventional separate hydrolysis and fermentation (62.12 g/L) and simultaneous saccharification and fermentation (52.41 g/L). The combined approach was effective for SA production. Approximately 75.46 g/L of SA content with a yield of 82.87% and a productivity of 1.35 g/L/h was obtained after 56 h in a 2 L bioreactor. Further studies will focus on increasing the working scale of the proposed method.
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http://dx.doi.org/10.1016/j.biortech.2017.09.208DOI Listing
February 2018
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