Publications by authors named "Qingsong Wang"

172 Publications

Carbon footprint and embodied carbon transfer at the provincial level of the Yellow River Basin.

Sci Total Environ 2021 Aug 30;803:149993. Epub 2021 Aug 30.

School of Architecture & Built Environment, The University of Adelaide, SA 5005, Australia.

The ecological conservation and high-quality development of China's Yellow River Basin is a national strategy proposed in 2019. Under China's goal of achieving a carbon peak by 2030 and carbon neutrality by 2060, clarifying the carbon footprint of each province and the transfer paths of embodied carbon emissions is crucial to the carbon reduction strategy for this region. This paper uses input-output model and multi-regional input-output model to account for the carbon footprint of nine provinces in the Yellow River Basin, and to estimate the amount of embodied carbon transfer between provinces and industrial sectors. Social network analysis is applied to identify the critical industries in the inter-provincial embodied carbon emission transfers from the three major industries. We found that the per capita carbon footprint of the Yellow River Basin decreased by 23.4% in 2017 compared to 2012. Among the sectoral composition of the carbon footprint of each province, "Processing and manufacturing of petroleum, coking, nuclear fuel, and chemical products", "Construction", "Other services", and "Metal processing and metal, non-metallic products" are the four sectors with a higher proportion of emissions. The embodied carbon emission transfer between the provinces in middle and lower reaches of the Yellow River Basin is much higher than that between the upstream provinces. Among carbon emission transfer network of three major industries in nine provinces,the secondary industry in Shaanxi has the highest centrality and is the most critical industry. This study provides a theoretical basis and data support for formulating carbon emission reduction plans in the Yellow River Basin.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149993DOI Listing
August 2021

New Insight into Desodiation/Sodiation Mechanism of MoS: Sodium Insertion in Amorphous Mo-S Clusters.

ACS Appl Mater Interfaces 2021 Sep 17;13(34):40481-40488. Epub 2021 Aug 17.

Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

Molybdenum disulfide (MoS) is a promising anode material for sodium batteries due to its high theoretical capacity. While significantly improved electrochemical performance has been achieved, the reaction mechanism is still equivocal. Herein, we applied electron pair distribution function and X-ray absorption spectroscopy to investigate the desodiation/sodiation mechanism of MoS electrodes. The results reveal that Mo-S bonds are well preserved and dominant in the sodiation product matrix but do not convert to metallic Mo and NaS even at deep sodiation. The MoS multilayer sheets break into disordered MoS clusters with modified octahedral symmetry during discharging. The long-range order was not rebuilt during subsequent charging but with partial recovery of the Mo-S coordination symmetry. The mechanism of the reaction is independent of the carbon matrix, although it prevents the MoS clusters from leaching into the electrolyte and thus contributes to an extended cycle life. This work refreshes the fundamental understanding of the desodiation/sodiation mechanism of MoS materials.
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http://dx.doi.org/10.1021/acsami.1c07743DOI Listing
September 2021

The biology of bone morphogenetic protein signaling pathway in cerebrovascular system.

Chin Neurosurg J 2021 Sep 1;7(1):36. Epub 2021 Sep 1.

Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China.

Bone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues. Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function. The disorder of cerebrovascular system will result into serious cerebrovascular diseases, which is gradually becoming a major threat to human health in modern society. In recent decades, many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system. This review will discuss the relationship between the two aspects, aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.
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http://dx.doi.org/10.1186/s41016-021-00254-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408949PMC
September 2021

Work Engagement of Employees in Moonlighting: A Moderated Mediation Model From a Boundaryless Career Perspective.

Front Psychol 2021 2;12:693547. Epub 2021 Aug 2.

International Business School, Beijing Foreign Studies University, Beijing, China.

Using a panel of 324 Chinese employees in public sectors, this paper examines the work engagement of employees in moonlighting with the proxy of boundaryless career orientations. We divided work engagement into job engagement and organizational engagement and test their relation to boundaryless career orientations. The results demonstrate that boundaryless career orientations are positively related to job engagement the mediating effects of role conflicts, and negatively related to organizational engagement through the mediating effects of the relational psychological contracts. Moreover, organizational climate for openness moderates the negative correlation between boundaryless career orientations and role conflicts. There is no significant evidence provided for a moderating effect of organizational climate for openness between boundaryless career orientations and relational psychological contracts.
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http://dx.doi.org/10.3389/fpsyg.2021.693547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365158PMC
August 2021

Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure.

Am J Transl Res 2021 15;13(6):6305-6311. Epub 2021 Jun 15.

Chengde Health Commission Chengde, Hebei Province, China.

Objective: This study was designed to investigate the levels and clinical significance of secretory frizzled-related protein 5 (sFRP5), retinol binding protein 4 (RBP-4) and N-terminal (NT)-pro hormone BNP (NT-proBNP) in patients with chronic heart failure (CHF).

Methods: Eighty-nine patients with CHF treated in our hospital were included as the observation group. Seventy-five healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The subjects in the observation group were divided into NYHA class II (n=23), NYHA class III (n=34) and NYHA class IV (n=32) according to NYHA classification, and the levels of sFRP5, RBP-4 and NT-proBNP as well as left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared in the three groups. Spearman correlation was used to analyze the relationship between sFRP5, RBP-4, NT-proBNP and LVEDD, LVEF. The ROC curves of sFRP5, RBP-4 and NT-proBNP for the diagnosis of CHF were plotted. Patients in the observation group were divided into a death group (n=30) and a survival group (n=59) according to the 1-year follow-up outcome, and the levels of sFRP5, RBP-4, and NT-proBNP were compared between the two groups.

Results: The observation group showed significantly higher levels of sFRP5, RBP-4, NT-proBNP and LVEDD, and a significantly lower level of LVEF than the control group. Spearman's correlation analysis showed that sFRP5, RBP-4, NT-proBNP were correlated with LVEDD and LVEF in CHF patients ( < 0.05). The ROC curve showed that the AUC of sFRP5, RBP-4 and NT-proBNP for CHF diagnosis were 0.9378, 0.9133, and 0.9375, respectively. sFRP5, RBP-4, and NT-proBNP in the death group were all higher than those in the survival group ( < 0.05).

Conclusion: sFRP5, RBP-4, and NT-proBNP showed a close correlation with CHF. It is worthy of using this method as a clinical index for the diagnosis and prognosis of CHF.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290780PMC
June 2021

Serum Heparanase: A New Clinical Biomarker Involved in Senile Metabolic Inflammatory Syndrome.

Diabetes Metab Syndr Obes 2021 13;14:3221-3228. Epub 2021 Jul 13.

Department of Geriatrics, Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, 200040, People's Republic of China.

Aim: Metabolic inflammation syndrome (MIS) can lead to a series of complications, but its exact inflammatory mechanism is still unclear. The aim of this study was to explore the correlation between heparanase (HPA) and MIS, and the close relationship between HPA and other chronic low-grade inflammation index, such as C-reactive protein (CRP) and interleukin-6 (IL-6).

Methods: A total of 105 patients with MIS in the physical examination population of Huashan Hospital affiliated to Fudan University from May to June 2018 were selected as the MIS group, and 52 patients who were relatively healthy during the same period were used as the control group. The basic clinical data of the selected candidates were collected, the levels of serum HPA, CRP and IL-6 were measured by ELISA, and the levels of blood glucose and blood lipids were also detected.

Results: Compared with the control group, the levels of HPA, CRP, IL-6, FBG, HbA, and TG of MIS group were all significantly elevated (all P<0.05), and HDL-C levels were considerably reduced (P<0.05). Correlation analysis showed that there was a noticeably positive correlation between serum HPA level and CRP, IL-6 levels (P<0.05).

Conclusion: Higher HPA levels might play a certain role in the occurrence and development of MIS. There was a certain close correlation between serum HPA level and CRP and IL-6 levels, and which indicated that HPA was involved in the chronic low-grade inflammatory reaction process of MIS.
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http://dx.doi.org/10.2147/DMSO.S291612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286426PMC
July 2021

A comparative study of EOF and NMF analysis on downward trend of AOD over China from 2011 to 2019.

Environ Pollut 2021 Jul 7;288:117713. Epub 2021 Jul 7.

School of Municipal and Environmental Engineering, Shandong Jianzhu University, Jinan, Shandong, 250101, China.

In recent decades China has experienced high-level PM pollution and then visible air quality improvement. To understand the air quality change from the perspective of aerosol optical depth (AOD), we adopted two statistical methods of Empirical Orthogonal Functions (EOF) and Non-negative Matrix Factorization (NMF) to AOD retrieved by MODIS over China and surrounding areas. Results showed that EOF and NMF identified the important factors influencing AOD over China from different angles: natural dusts controlled the seasonal variation with contribution of 42.4%, and anthropogenic emissions have larger contribution to AOD magnitude. To better observe the interannual variation of different sources, we removed seasonal cycles from original data and conducted EOF analysis on AOD monthly anomalies. Results showed that aerosols from anthropogenic sources had the greatest contribution (27%) to AOD anomaly variation and took an obvious downward trend, and natural dust was the second largest contributor with contribution of 17%. In the areas surrounding China, the eastward aerosol transport due to prevailing westerlies in spring significantly influenced the AOD variation over West Pacific with the largest contribution of 21%, whereas the aerosol transport from BTH region in winter had relative greater impact on the AOD magnitude. After removing seasonal cycles, biomass burning in South Asia became the most important influencing factor on AOD anomalies with contribution of 10%, as its interannual variability was largely affected by El Niño. Aerosol transport from BTH was the second largest contributor with contribution of 8% and showed a decreasing trend. This study showed that the downward trend of AOD over China since 2011 was dominated by aerosols from anthropogenic sources, which in a way confirmed the effectiveness of air pollution control policies.
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http://dx.doi.org/10.1016/j.envpol.2021.117713DOI Listing
July 2021

Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.

Mol Cell Proteomics 2021 Jul 13;20:100121. Epub 2021 Jul 13.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China. Electronic address:

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have poor overall survival because of limited molecular therapeutic targets. Recently, exosomes have been recognized as key mediators in cancer progression, but the molecular components and function of TNBC-derived exosomes remain unknown. The main goal of this study was to reveal the proteomic landscape of serum exosomes derived from ten patients with TNBC and 17 healthy donors to identify potential therapeutic targets. Using a tandem mass tag-based quantitative proteomics approach, we characterized the proteomes of individual patient-derived serum exosomes, identified exosomal protein signatures specific to patients with TNBC, and filtered out differentially expressed proteins. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes. Our findings indicate that profiling of TNBC-derived exosomal proteins is a useful tool to extend our understanding of TNBC, and exosomal CD151 may be a potential therapeutic target for TNBC.
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http://dx.doi.org/10.1016/j.mcpro.2021.100121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379346PMC
July 2021

Effects of different plastic film mulching on soil hydrothermal conditions and grain-filling process in an arid irrigation district.

Sci Total Environ 2021 Nov 5;795:148886. Epub 2021 Jul 5.

Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas, Ministry of Education, Northwest A&F University, Yangling 712100, China; College of Water Resources and Architectural Engineering, Northwest A&F University, Yangling 712100, Shaanxi Province, China; Institute of Water-saving Agriculture in Arid Areas of China, Northwest A&F University, Yangling 712100, China; Institute of Soil and Water Conservation, Northwest A & F University, Yangling 712100, China. Electronic address:

Plastic film mulching has been extensively used for spring maize (Zea mays L.) production in the Hetao Irrigation District (HID). Determining whether transparent plastic film mulching results in premature senescence and yield reduction of spring maize still needs to be verified. A two-year field experiment was conducted in the HID that involved planting spring maize under three mulching practices on a flat plot 1) without mulching (control treatment, CK), 2) with black plastic film mulching (BM), 3) with transparent plastic film mulching (TM). The results indicated that TM and BM were superior to CK in terms of effects on soil hydrothermal conditions. Compared with BM, TM produced significantly higher soil temperature at V6, and had no significant temperature effect at V12, R1, R3, and R6. Both TM and BM promoted early seedling emergence and earlier silking, and TM extended the duration of the reproductive stages by 1-2 days compared with BM, and 4-5 days longer than CK. TM and BM produced greater kernel weights and kernel volumes in the superior and middle portions of the ear than CK. TM produced significantly greater total kernel weights per ear than BM at and after 23 days after silking. TM significantly increased grain-filling rate and length of the active grain-filling period compared with BM and CK. Additionally, TM and BM produced significantly higher photosynthetic parameters than CK at the grain-filling stage in the two study years. The net photosynthesis rate for TM was significantly greater than for BM. TM and BM significantly increased grain yields by 28.1% and 15.1%, respectively, in 2019 over CK, and by 24.6% and 21.1% in 2020. Transparent plastic film mulching could serve as a promising adaptive management practice to increase resource use efficiency and to improve maize productivity in the HID.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148886DOI Listing
November 2021

High-Entropy Metal-Organic Frameworks for Highly Reversible Sodium Storage.

Adv Mater 2021 Aug 9;33(34):e2101342. Epub 2021 Jul 9.

Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

Prussian blue analogues (PBAs) are reported to be efficient sodium storage materials because of the unique advantages of their metal-organic framework structure. However, the issues of low specific capacity and poor reversibility, caused by phase transitions during charge/discharge cycling, have thus far limited the applicability of these materials. Herein, a new approach is presented to substantially improve the electrochemical properties of PBAs by introducing high entropy into the crystal structure. To achieve this, five different metal species are introduced, sharing the same nitrogen-coordinated site, thereby increasing the configurational entropy of the system beyond 1.5R. By careful selection of the elements, high-entropy PBA (HE-PBA) presents a quasi-zero-strain reaction mechanism, resulting in increased cycling stability and rate capability. The key to such improvement lies in the high entropy and associated effects as well as the presence of several active redox centers. The gassing behavior of PBAs is also reported. Evolution of dimeric cyanogen due to oxidation of the cyanide ligands is detected, which can be attributed to the structural degradation of HE-PBA during battery operation. By optimizing the electrochemical window, a Coulombic efficiency of nearly 100% is retained after cycling for more than 3000 cycles.
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http://dx.doi.org/10.1002/adma.202101342DOI Listing
August 2021

Evaluation and optimization of a circular economy model integrating planting and breeding based on the coupling of emergy analysis and life cycle assessment.

Environ Sci Pollut Res Int 2021 Jul 1. Epub 2021 Jul 1.

National Engineering Laboratory for Reducing Emissions from Coal Combustion, Engineering Research Center of Environmental Thermal Technology of Ministry of Education, Shandong Key Laboratory of Energy Carbon Reduction and Resource Utilization, Research Center for Sustainable Development, Jinan, 250061, Shandong, China.

The sustainable development of agriculture is facing problems such as high resource consumption and serious environmental pollution. The development of the circular economy model integrating planting and breeding (CEMIPB) has become an effective way to realize the sustainable development of agriculture. Due to the great difference of natural resource attributes in different regions of China, CEMIPB shows diverse characteristics on the whole. Based on this, this paper constructs a coupling model based on emergy analysis (EMA) and life cycle assessment (LCA) called EM-LCA model and conducts an empirical analysis using a typical CEMIPB in Fujian Province, China, as a case. By comparing the results of the EM-LCA and EMA models, the former effectively compensates for the deficiencies of the latter in terms of economic and environmental impact assessment, and the evaluation results can better reflect the actual situation of the system. Furthermore, sensitivity analysis is introduced to identify key processes and substances. Based on the reduce-reuse-recycle (3R) principle, several optimization suggestions, such as reducing the input of corn and veterinary drugs, are put forward. The construction of the aforementioned methodology system can provide a new perspective for research in similar fields and provide a scientific basis for local government decision making.
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http://dx.doi.org/10.1007/s11356-021-15101-zDOI Listing
July 2021

CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion.

Biochimie 2021 Jun 23;189:65-75. Epub 2021 Jun 23.

Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, 100190, PR China. Electronic address:

Breast cancer is the most common and highly heterogeneous disease in women worldwide. Given the challenges in the treatment of advanced metastatic breast cancer, it is necessary to understand the molecular mechanisms related to disease progression. Exosomes play various roles in the progression of tumors, including promoting the invasion and advancing the distant metastasis. To study the molecular mechanisms related to the progression of luminal androgen receptor (LAR) breast cancer, we first isolated exosomes of MDA-MB-453 cells, a representative cell line of LAR. Through quantitative proteomic analysis, we identified 180 proteins specifically enriched in exosomes after comparing with those in cells, microvesicles, and the 150K supernatant. Among these, CD151, a protein involved in the regulation of cell motility was the most enriched one. CD151-knockdown exosomes reduced the invasion ability of the recipient breast cancer cell and lowered the phosphorylation level of tyrosine-protein kinase Lck, indicating that the invasion of LAR breast cancer may be due to CD151-enriched exosomes. Our work reports for the first time that CD151 was highly abundant in the exosomes of MDA-MB-453 cells and expands the understanding of the development process of LAR subtype, suggesting CD151 may be a potential candidate for the treatment of LAR breast cancer.
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http://dx.doi.org/10.1016/j.biochi.2021.06.007DOI Listing
June 2021

Early Hospital Arrival After Acute Ischemic Stroke Is Associated With Family Members' Knowledge About Stroke.

Front Neurol 2021 26;12:652321. Epub 2021 May 26.

Department of Neurology, The General Hospital of Western Theater Command, Chengdu, China.

Prehospital delay is the major factor limiting intravenous thrombolysis and mechanical thrombectomy in acute ischemic stroke (AIS). This study aimed to: (1) identify factors related to prehospital delay and (2) determine the impact of recognition and behavior of family members on patient delay. A cross-sectional, multicenter study was conducted at six teaching hospitals in China between December 1, 2018 and November 30, 2019. Patients who experienced AIS within 7 days of onset were interviewed. Of 1,782 consecutive patients (male, 57.97%; mean age, 66.3 ± 9.65 years) who had an AIS, 267 (14.98%) patients arrived within 4.5 h and 722 (40.52%) patients arrived within 6 h of stroke onset. Among patients who arrived within 4.5 h, 103 (38.6%) received thrombolysis. Age over 65 years (OR, 2.009; 95% CI, 1.014-3.982), prior stroke (OR, 3.478; 95% CI, 1.311-9.229), blurred vision (OR, 3.95; 95% CI, 1.71-9.123), and patients deciding to seek medical help (OR, 3.097; 95% CI, 1.417-6.769) were independently associated with late arrival. In contrast, sudden onset of symptoms (OR, 0.075; 95% CI, 0.028-0.196), the National Institutes of Health Stroke Scale 7-15 (OR, 0.093; 95% CI, 0.035-0.251), consciousness disturbance (OR, 0.258; 95% CI, 0.091-0.734), weakness (OR, 0.265; 95% CI, 0.09-0.784), arrival by ambulance (OR, 0.102; 95% CI, 0.049-0.211), decision time <30 min (OR, 0.008; 95% CI, 0.003-0.018), and family member understanding stroke requires early treatment (OR, 0.224; 95% CI, 0.109-0.462) were independently associated with early arrival. The prehospital delay in China lags behind Western countries. Recognition and behavior of stroke patients' family members may play a key role in early arrival.
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http://dx.doi.org/10.3389/fneur.2021.652321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187751PMC
May 2021

The clinical significance of changes in cTnT, CRP and NT-proBNP levels in patients with heart failure.

Am J Transl Res 2021 15;13(4):2947-2954. Epub 2021 Apr 15.

Emergency Department, Affiliated Hospital of Chengde Medical College Chengde 067000, Hebei Province, China.

Objective: This study was designed to explore the clinical significance of changes in troponin T (cTnT), C-reactive protein (CRP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with heart failure (HF).

Methods: A total of 193 patients with HF admitted to our hospital from October 2013 to June 2019 were enrolled as the study subjects (group A). Another 191 healthy controls were included as group B. Both groups were compared in terms of cTnT, CRP, NT-proBNP levels and left ventricular ejection fraction (LVEF), and the correlations between LVEF and cTnT, CRP, NT-proBNP were analyzed. The differences in cTnT, CRP, NT-proBNP were compared among patients with different cardiac function, different causes of HF, and between patients with and without cardiac events.

Results: cTnT, CRP, and NT-proBNP levels in group A were higher than those in group B (<0.05). LVEF in group A was lower than that in group B (<0.05). Negative correlations were found between CRP, cTnT, NT-proBNP and LVEF (<0.05). As cardiac function improved, cTnT, CRP, NT-proBNP levels also increased, with significant differences between groups (<0.05). cTnT, CRP, and NT-proBNP levels exhibited no significant difference between the ischemic and non-ischemic HF groups (>0.05). Patients with cardiac events showed higher levels of cTnT, CRP, and NT-proBNP than those without cardiac events (<0.05).

Conclusion: cTnT, CRP and NT-proBNP levels were elevated in patients with HF, which were negatively correlated with LVEF, and their levels increased with the improvement of cardiac function, independent of the cause of HF. The combination of these three indices is of great significance in the diagnosis and prognosis of HF.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129395PMC
April 2021

Plasma Neurofilament Light Chain as a Predictive Biomarker for Post-stroke Cognitive Impairment: A Prospective Cohort Study.

Front Aging Neurosci 2021 19;13:631738. Epub 2021 Feb 19.

Department of Neurology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Plasma neurofilaments light chain (pNfL) is a marker of axonal injury. The purpose of this study was to examine the role of pNfL as a predictive biomarker for post-stroke cognitive impairment (PSCI).

Methods: A prospective single-center observational cohort study was conducted at the General Hospital of Western Theater Command between July 1, 2017 and December 31, 2019. Consecutive patients ≥18 years with first-ever acute ischemic stroke (AIS) of anterior circulation within 24 h of symptom onset were included. PSCI was defined by the Montreal Cognitive Assessment (MOCA) (MOCA < 26) at 90 days after stroke onset.

Results: A total of 1,694 patients [male, 893 (52.70%); median age, 64 (16) years] were enrolled in the cohort analysis, and 1,029 (60.70%) were diagnosed with PSCI. Patients with PSCI had significantly higher pNfL [median (IQR), 55.96 (36.13) vs. 35.73 (17.57) pg/ml; < 0.001] than Non-PSCI. pNfL was valuable for the prediction of PSCI (OR 1.044, 95% CI 1.038-1.049, < 0.001) after a logistic regression analysis, even after adjusting for conventional risk factors including age, sex, education level, NIHSS, TOAST classification, and infarction volume (OR 1.041, 95% CI 1.034-1.047, < 0.001). The optimal cutoff value of the pNfL concentration was 46.12 pg/ml, which yielded a sensitivity of 71.0% and a specificity of 81.5%, with the area under the curve (AUC) at 0.785 (95% CI 0.762-0.808, < 0.001).

Conclusion: This prospective cohort study showed that the pNfL concentration within 48 h of onset was an independent risk factor for PSCI 90 days after an anterior circulation stroke, even after being adjusted for potential influencing factors regarded as clinically relevant.

Clinical Trial Registration: www.chictr.org.cn, identifier ChiCTR1800020330.
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http://dx.doi.org/10.3389/fnagi.2021.631738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933545PMC
February 2021

Evaluation and optimization of blanket production from recycled polyethylene terephthalate based on the coordination of environment, economy, and society.

Sci Total Environ 2021 Jun 2;772:145049. Epub 2021 Feb 2.

Medical Data Research Center, Providence Health & Services, 9205 SW Barnes Road, Portland, OR 97225, USA.

The recycling of waste polyethylene terephthalate (PET) is widely regarded as an eco-friendly and cost-effective technology and has been gradually developed into an important direction for the utilization of solid waste resources. However, the integrated evaluation research on this technology from the environmental, economic, and social aspects are still not in place. Based on the theory of collaborative entropy, this study constructs an integrated evaluation and optimization methodology system for the environmental, economic, and social impacts of blanket production from recycled PET, using environmental life cycle assessment, life cycle cost assessment, social life cycle assessment, and sensitivity analysis. The study assessed the environmental load, economic cost, and social impact of blanket production from recycled PET, and then identified the key processes through sensitivity analysis. In addition, the graphical method and the principle of collaborative entropy model are applied to evaluate two of the environmental load, economic cost, and social impact in the blanket production from recycled PET. The results of the two methods are consistent, which indicates that to carry out multi-objective integrated evaluation with collaborative entropy model have good reliability. Moreover, the quantified results of collaborative entropy showed that the key processes that affected the coordinated development of the environment, economy, and society were organic chemicals usage process, electricity generation process, and direct air emission process. Based on the "Reduce-Reuse-Recycle" theory and the position of key processes in the system, feasible optimization suggestions were proposed. The establishment of this methodology system could provide theoretical and practical references for other waste utilization industry.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145049DOI Listing
June 2021

One-Step Fabrication Method of GaN Films for Internal Quantum Efficiency Enhancement and Their Ultrafast Mechanism Investigation.

ACS Appl Mater Interfaces 2021 Feb 8;13(6):7688-7697. Epub 2021 Feb 8.

Laser Assisted Nano Engineering Laboratory, Department of Electrical Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0511, United States.

The third-generation semiconductors are the cornerstone of the power semiconductor leap forward and have attracted much attention because of their excellent properties and wide applications. Meanwhile, femtosecond laser processing as a convenient method further improves the performance of the related devices and expands the application prospect. In this work, an approximate 3 times improvement of the internal quantum efficiency (IQE) and a 5.5 times enhancement of the photoluminescence (PL) intensity were achieved in the GaN film prepared using a one-step femtosecond laser fabrication method. Three types of final micro/nanostructures were found with different femtosecond laser fluences, which could be attributed to the decomposition, melting, bubble nucleation, and phase explosion of GaN. The mechanisms of the microbump structure formation and enhancement of IQE were studied experimentally by the time-resolved reflection pump-probe technique, X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Simulations for the laser-GaN interaction have also been performed to ascertain the micro/nanostructure formation principle. These results promote the potential applications of femtosecond lasers on GaN and other wide band gap semiconductors, such as UV-light-emitting diodes (LEDs), photodetectors, and random lasers for use in sensing and full-field imaging.
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http://dx.doi.org/10.1021/acsami.0c19726DOI Listing
February 2021

Association between infectious burden and cerebral microbleeds: a pilot cross-sectional study.

Ann Clin Transl Neurol 2021 02 7;8(2):395-405. Epub 2021 Jan 7.

Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Objective: Cerebral microbleeds (CMBs) is a subtype of cerebral small vessel disease. Their underlying pathogenesis remains unclear. The aim of this study was to investigate the association between infectious burden (IB) and CMBs.

Methods: Seven hundred and seventy-three consecutive patients who were hospitalized in the Department of Neurology in General Hospital of Western Theater Command without severe neurological symptoms were recruited and selected in this pilot cross-sectional study. CMBs were assessed using the susceptibility-weighted imaging sequence of magnetic resonance imaging. Immunoglobulin G antibodies against common pathogens, including herpes simplex virus (HSV)-1, HSV-2, cytomegalovirus (CMV), Chlamydia pneumoniae (C. pneumoniae), Mycoplasma pneumoniae (M. pneumoniae), Epstein-Barr virus (EBV), Helicobacter pylori (HP), and Borrelia burgdorferi (B. burgdorferi), were measured by commercial ELISA assays. IB was defined as a composite serologic measure of exposure to these common pathogens.

Results: Patients with and without CMBs were defined as the CMBs group (n = 76) and the non-CMBs group (n = 81), respectively. IB was significantly different between the CMBs and non-CMBs groups. After adjusted for other risk factors, the increased IB was independently associated with the presence of CMBs (P = 0.031, OR = 3.00, 95% CI [1.11-8.15]). IB was significantly positively associated with the number of CMBs (Spearman ρ = 0.653, P < 0.001). The levels of serum inflammatory markers were significantly different between the CMBs and non-CMBs groups and among the categories of IB.

Interpretation: IB consisting of HSV-1, HSV-2, CMV, C. pneumoniae, M. pneumoniae, EBV, HP, and B. burgdorferi was associated with CMBs. All the findings suggested that pathogen infection could be involved in the pathogenesis of CMBs.
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http://dx.doi.org/10.1002/acn3.51285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886034PMC
February 2021

Mass spectrometry-based screening identifies circulating immunoglobulinA-α1-microglobulin complex as potential biomarker in immunoglobulin A nephropathy.

Nephrol Dial Transplant 2021 04;36(5):782-792

Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China, and Peking University Institute of Nephrology, Beijing, China.

Background: Immunoglobulin A nephropathy (IgAN) is characterized by predominant IgA deposition in the glomerular mesangium. Previous studies have proved that renal-deposited IgA in IgAN came from circulating IgA1-containing complexes (CICs).

Methods: To explore the composition of CICs in IgAN, we isolated CICs from IgAN patients and healthy controls and then quantitatively analyzed them by mass spectrometry. Meanwhile, the isolated CICs were used to treat human mesangial cells to monitor mesangial cell injury. Using the protein content and injury effects, the key constituent in CICs was identified. Then the circulating levels of identified key constituent-IgA complex were detected in an independent population by an in-house-developed enzyme-linked immunosorbent assay.

Results: By comparing the proteins of CICs between IgAN patients and controls, we found that 14 proteins showed significantly different levels. Among them, α1-microglobulin content in CICs was associated with not only in vitro mesangial cell proliferation and monocyte chemoattractant protein 1 secretion, but also in vivo estimated glomerular filtration rate (eGFR) levels and tubulointerstitial lesions in IgAN patients. Moreover, we found α1-microglobulin was prone to bind aberrant glycosylated IgA1. Additionally, elevated circulating IgA-α1-microglobulin complex levels were detected in an independent IgAN population and IgA-α1-microglobulin complex levels were correlated with hypertension, eGFR levels and Oxford T- scores in these IgAN patients.

Conclusions: Our results suggest that the IgA-α1-microglobulin complex is an important constituent in CICs and that circulating IgA-α1-microglobulin complex detection might serve as a potential noninvasive biomarker detection method for IgAN.
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http://dx.doi.org/10.1093/ndt/gfaa352DOI Listing
April 2021

Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis.

PLoS One 2020 13;15(11):e0241241. Epub 2020 Nov 13.

Tianjin Research Center of Basic Medical Sciences, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Nuclear factor erythroid 2-related factor 2 (NRF2) functions as a transcription factor and regulates a wide array of antioxidant and stress-responsive genes. NRF2 has been widely implicated in different types of cancers, but only limited studies concerning the relationship between NRF2 expression and tumour invasion or prognosis in lung cancer. Therefore, we conducted a meta-analysis to determine the prognostic value of NRF2 in patients with non-small cell lung cancer (NSCLC). The relationship between NRF2 expression in NSCLC patients and clinicopathological features was also investigated. Overall survival (OS) and treatment response rate were evaluated using STATA software. Twenty eligible articles with 2530 lung cancer patients were included in this meta-analysis. The results revealed that high expression level of NRF2 was associated with pathologic distant metastasis (odds ratio (OR) = 2.64, 95% confidence interval (CI) 1.62-4.31; P < 0.001), lymph node metastasis (OR = 2.14, 95% CI: 1.53-3.00; P < 0.001), and tumour node metastasis (TNM) stage (OR = 1.95, 95% CI: 1.52-2.49, P < 0.001). High NRF2 expression was associated with low treatment response rate in platinum-based chemotherapy (HR = 0.11, 95% CI 0.02-0.51; P = 0.005). High expression level of NRF2 is predictive for poor overall survival rate (HR = 1.86, 95% CI 1.44-2.41, P < 0.001) and poor progression-free survival (PFS) (HR = 2.27, 95% CI 1.26-4.09, P = 0.006). Compared to patients with a low level of NRF2 expression, patients with high NRF2 expression levels were associated with worse OS and PFS when given the chemotherapy or EGFR-TKI. Together, our meta-analysis results suggest that NRF2 can act as a potential indicator of NSCLC tumour aggressiveness and help the prognosis and design of a better treatment strategy for NSCLC patients.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665804PMC
December 2020

Lithium containing layered high entropy oxide structures.

Sci Rep 2020 Oct 28;10(1):18430. Epub 2020 Oct 28.

Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

Layered Delafossite-type Li(MMMMM…M)O materials, a new class of high-entropy oxides, were synthesized by nebulized spray pyrolysis and subsequent high-temperature annealing. Various metal species (M = Ni, Co, Mn, Al, Fe, Zn, Cr, Ti, Zr, Cu) could be incorporated into this structure type, and in most cases, single-phase oxides were obtained. Delafossite structures are well known and the related materials are used in different fields of application, especially in electrochemical energy storage (e.g., LiNiCoMnO [NCM]). The transfer of the high-entropy concept to this type of materials and the successful structural replication enabled the preparation of novel compounds with unprecedented properties. Here, we report on the characterization of a series of Delafossite-type high-entropy oxides by means of TEM, SEM, XPS, ICP-OES, Mössbauer spectroscopy, XRD including Rietveld refinement analysis, SAED and STEM mapping and discuss about the role of entropy stabilization. Our experimental data indicate the formation of uniform solid-solution structures with some Li/M mixing.
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http://dx.doi.org/10.1038/s41598-020-75134-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595184PMC
October 2020

Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex.

Neural Regen Res 2021 Apr;16(4):750-756

Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China.

Regenerating functional new neurons in the adult mammalian central nervous system has been proven to be very challenging due to the inability of neurons to divide and repopulate themselves after neuronal loss. Glial cells, on the other hand, can divide and repopulate themselves under injury or diseased conditions. We have previously reported that ectopic expression of NeuroD1 in dividing glial cells can directly convert them into neurons. Here, using astrocytic lineage-tracing reporter mice (Aldh1l1-CreER mice crossing with Ai14 mice), we demonstrate that lineage-traced astrocytes can be successfully converted into NeuN-positive neurons after expressing NeuroD1 through adeno-associated viruses. Retroviral expression of NeuroD1 further confirms that dividing glial cells can be converted into neurons. Importantly, we demonstrate that for in vivo cell conversion study, using a safe level of adeno-associated virus dosage (10-10 gc/mL, 1 µL) in the rodent brain is critical to avoid artifacts caused by toxic dosage, such as that used in a recent bioRxiv study (2 × 10 gc/mL, 1 µL, mouse cortex). For therapeutic purpose under injury or diseased conditions, or for non-human primate studies, adeno-associated virus dosage needs to be optimized through a series of dose-finding experiments. Moreover, for future in vivo glia-to-neuron conversion studies, we recommend that the adeno-associated virus results are further verified with retroviruses that mainly express transgenes in dividing glial cells in order to draw solid conclusions. The study was approved by the Laboratory Animal Ethics Committee of Jinan University, China (approval No. IACUC-20180330-06) on March 30, 2018.
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http://dx.doi.org/10.4103/1673-5374.295925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067918PMC
April 2021

Economic transition and industrial sulfur dioxide emissions in the Chinese economy.

Sci Total Environ 2020 Nov 12;744:140826. Epub 2020 Jul 12.

School of Architecture & Built Environment, The University of Adelaide, SA 5005, Australia.

China transitioned into "new normal phase" during 2007 to 2017, shifting from pursuing rapid GDP growth to a win-win state of economic development and environmental improvement. Using the input-output (IO) table for 2007-2012 and the latest IO table for 2012-2017, an IO model of China's industrial SO emissions is established and structural decomposition analysis (SDA) is applied to examine the changes in industrial SO emissions resulting from this economic transition. Five influencing factors (emission intensity, production technology, final demand expenditure, final demand structure and economic scale) are taken into consideration. The analysis shows that emission intensity and economic scale are the most influential factors on SO emissions. Emission intensity reduced SO emissions by 16,560,886 t in 2012-2017 whilst economic scale increased SO emissions by 473,490 t. Compared with the period 2007-2012, the contribution rate of emission intensity increased from -82.3% to -189.2%, while that of economic scale decreased from 131.8% to 54.1%. The total contributions of 5 factors to SO reduction increased from -5,249,417 t to -12,783,248 t, and the contribution rate increased from -24.8% to -146%. China's energy conservation and emission reduction has achieved remarkable results between 2007 and 2017. In "new normal phase", the slowing of China economic growth, the transition of economic development, industrial structural adjustment and rational consumption habits have had significant effects in reducing environmental pollution.
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http://dx.doi.org/10.1016/j.scitotenv.2020.140826DOI Listing
November 2020

Environmental and human health risk evaluation of heavy metals in ceramsites from municipal solid waste incineration fly ash.

Environ Geochem Health 2020 Nov 27;42(11):3779-3794. Epub 2020 Jun 27.

National Engineering Laboratory for Reducing Emissions from Coal Combustion, School of Energy and Power Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, China.

Municipal solid waste incineration (MSWI) for power generation can reuse waste effectively, but it generates a large amount of fly ash enriched with heavy metals. If this fly ash cannot be treated properly, it can cause ecological damage and human health risk. According to the production of ceramsites from MSWI fly ash, an evaluation methodology is established, in which the influence of heavy metal stability on the environment is considered for the first time, and the health risks of heavy metals via different exposure pathways are distinguished. The results show that heavy metals in MSWI fly ash have moderate potential environmental risks to environment and have strong non-carcinogenic and carcinogenic risks both to children and adults. By contrast, heavy metals in ceramsites pose little risk to environment and human health. This paper explains some reasons of heavy metal content and leaching ratio change in ceramsite and also illustrates why stability is a concern through comparing the potential risk index method and the improved evaluation method. This evaluation system can be applied to different production processes of building materials using solid hazardous waste and provides a quantitative evaluation method for reducing environment and human health risks of heavy metals.
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http://dx.doi.org/10.1007/s10653-020-00639-7DOI Listing
November 2020

Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation.

Light Sci Appl 2020 6;9:80. Epub 2020 May 6.

5Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455 USA.

Numerous valuable studies on electron dynamics have focussed on the extraordinary properties of molybdenum disulfide (MoS); however, most of them were confined to the level below the damage threshold. Here the electron dynamics of MoS under intense ultrafast laser irradiation was investigated by experiments and simulations. Two kinds of ablation mechanisms were revealed, which led to two distinct types of electron dynamics and final ablation morphology. At a higher fluence, the emergence of superheated liquid induced a dramatic change in the transient reflectivity and micro-honeycomb structures. At a lower fluence, the material was just removed by sublimation, and the ablation structure was relatively flat. X-ray photoelectron spectroscopic (XPS) measurements demonstrated that thermal decomposition only occurred at the higher fluence. Furthermore, a theoretical model was developed to deeply reveal the ultrafast dynamics of MoS ablation. The simulation results were in good agreement with the temporal and spatial reflectivity distribution obtained from the experiment. The electron and lattice temperature evolution was also obtained to prove the ablation mechanism. Our results revealed ultrafast dynamics of MoS above the damage threshold and are helpful for understanding the interaction mechanism between MoS and intense ultrafast lasers, as well as for MoS processing applications.
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http://dx.doi.org/10.1038/s41377-020-0318-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203173PMC
May 2020

Boosting Potassium Storage Performance of the CuS Anode Morphology Engineering and Electrolyte Chemistry.

ACS Nano 2020 May 28;14(5):6024-6033. Epub 2020 Apr 28.

State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, Anhui 230026, China.

Transition metal sulfides (TMSs) have been demonstrated as attractive anodes for potassium-ion batteries (KIBs) due to the high capacity, abundant resource, and excellent redox reversibility. Unfortunately, practical implementation of TMSs to KIBs is still hindered by the unsatisfactory cyclability and rate performance which result from the vast volume variation during charge/discharge processes. Herein, a uniform nitrogen-doped carbon coated CuS hollow nanocube ([email protected]) is designed as an anode material for the KIB, which displays an outstanding cycle performance (317 mAh g after 1200 cycles at 1 A g) and excellent rate capacity (257 mAh g at 6 A g) in a half-cell. The hollow nanosized structure can both shorten the diffusion length of potassium ions/electrons and buffer the volume expansion upon cycling. Besides, the high concentration electrolyte is beneficial to form the stable solid electrolyte interphase (SEI) film, reducing the interface impedance and enhancing the cycling stability. transmission electron microscopy (TEM) and X-ray diffraction (XRD) reveal the reaction mechanism of [email protected]
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http://dx.doi.org/10.1021/acsnano.0c01681DOI Listing
May 2020

Life cycle assessment of ultra-low treatment for steel industry sintering flue gas emissions.

Sci Total Environ 2020 Jul 2;725:138292. Epub 2020 Apr 2.

School of Architecture & Built Environment, The University of Adelaide, SA 5005, Australia.

The largest contributor to pollutant emissions is the sintering process in steel industry. Ultra-low emission policy for the Chinese steel industry states that emission concentrations of particulate matter, SO and NO should not exceed 10, 35 and 50 mg/m respectively. The emission concentrations of the steel industry are the same as the ultra-low emission policy for the coal-fired power industry, but the pollutant control technologies of the two industries are different. Life cycle assessment method is applied to analyze the latest ultra-low treatment process for sintering flue gas emissions which includes electrostatic precipitation, ozone oxidation, wet desulfurization, wet denitration, condensation dehumidification and wet electrostatic precipitation. Following this novel ultra-low emission treatment, the concentrations of particulate matter, SO, NO, and PCDDs in the sintering flue gas decreased very significantly, attaining the new emission standard. With 1 ton of sinter as the functional unit and "cradle to gate" as the system boundary, the environmental impact of the process is 0.1811 and the total economic cost is 172.79 RMB, of which internal cost is 34.64 RMB and external cost is 138.15 RMB. The main environmental impacts result from applying the wet denitration and ozone oxidation processes. Sodium sulfite in the wet denitration process, and electricity and liquid oxygen in the ozone oxidation process are the key inputs that cause environmental impact. These findings are useful for a further optimization of the ultra-low emissions process from both the environmental and economic perspective, which is applicable in other regions of the world.
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http://dx.doi.org/10.1016/j.scitotenv.2020.138292DOI Listing
July 2020
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