Publications

AK098656, a Novel Vascular Smooth Muscle Cell-Dominant Long Noncoding RNA, Promotes Hypertension.
Hypertension 2018 Feb 26;71(2):262-272. Epub 2017 Dec 26.
From the Hypertension Center of Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.J., W.W., S.L., X.C., B.G., J.C.); Department of Biomedical Informatics, Physiology, and Pathophysiology, Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing, China (X.L., J.Y., Q.C., B.G.); Department of Cardiology, Medical Research Center, Chaoyang Hospital, Capital Medical University, Beijing, China (L.Y., J.L., X.L., M.B.); and Institute of Hypoxia Medicine, Wenzhou Medical University, Zhejiang, China (X.F.).

Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide.
Antioxid Redox Signal 2018 Jan 17. Epub 2018 Jan 17.
Department of Physiology and Pathophysiology, Peking University Health Science Center , NO.38, Xueyuan Road, Haidian District, Beijing, China , Bei Jing, China , 100191 ;

FAM3C activates HSF1 to suppress hepatic gluconeogenesis and attenuate hyperglycemia of type 1 diabetic mice.
Oncotarget 2017 Dec 20;8(62):106038-106049. Epub 2017 Nov 20.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of The Ministry of Education Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China.

Cystathionine γ-Lyase-Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing.
Antioxid Redox Signal 2017 Oct 10;27(11):742-753. Epub 2017 Mar 10.
1 Hypertension Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases , Beijing, China .

FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation of ATP-P2 receptor-Akt signaling pathway.
Oncotarget 2017 Jul;8(28):45862-45873
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Beijing 100191, China.

FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress.
Oncotarget 2017 Jul;8(30):49882-49896
Department of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China.

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.
Circ Res 2016 Jul 5;119(2):261-76. Epub 2016 May 5.
From the Department of Physiology and Pathophysiology (Y.F., C.G., Y.L., M.W., Y.H., T.L., Y.J., F.Y., X.W., W.K.), Department of Biomedical Informatics (W.M., Q.C.), Institute of Cardiovascular Sciences, School of Basic Medical Sciences (Y.L.), Peking University, Beijing, P. R. China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, P. R. China (Y.F., C.G., Y.L., M.W., Y.H., W.M., T.L., Y.J., F.Y., Q.C., Y.L., X.W., W.K.); School of Biological Science and Medical Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing, P. R. China (W.Z.); and Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (Q.X.).

Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.
Biochim Biophys Acta 2016 May 2;1861(5):419-29. Epub 2016 Mar 2.
Department of Physiology and Pathophysiology, Peking University Health Science Center, PR China; Center for Noncoding RNA Medicine, Peking University Health Science Center, PR China; Hypertension Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China. Electronic address:

FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury.
J Mol Cell Cardiol 2014 Sep 23;74:173-82. Epub 2014 May 23.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing 100191, China. Electronic address:

HMDD v2.0: a database for experimentally supported human microRNA and disease associations.
Nucleic Acids Res 2014 Jan 4;42(Database issue):D1070-4. Epub 2013 Nov 4.
Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China and MOE Key Lab of Cardiovascular Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.

MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1.
PLoS One 2013 11;8(9):e74504. Epub 2013 Sep 11.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China.

Comparison Analysis of Dysregulated LncRNA Profile in Mouse Plasma and Liver after Hepatic Ischemia/Reperfusion Injury.
PLoS One 2015 29;10(7):e0133462. Epub 2015 Jul 29.
Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing, 100191, China; MOE Key Lab of Molecular Cardiovascular Science, Peking University, 38 Xueyuan Road, Beijing, 100191, China; Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.

LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations.
Nucleic Acids Res 2016 05 16;44(9):e90. Epub 2016 Feb 16.
Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China MOE Key Lab of Cardiovascular Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China Beijing Key Laboratory of Tumor Systems Biology, Peking University, 38 Xueyuan Road, Beijing 100191, China

SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features.
Nucleic Acids Res 2016 06 20;44(10):e91. Epub 2016 Feb 20.
Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China MOE Key Lab of Molecular Cardiovascular Sciences, Peking University, Beijing 100191, China Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing 100191, China

Gut microbiota dysbiosis contributes to the development of hypertension.
Microbiome 2017 02 1;5(1):14. Epub 2017 Feb 1.
Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice.
Diabetes 2017 05 28;66(5):1185-1197. Epub 2017 Feb 28.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, China

NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.
Diabetes 2017 07 14;66(7):1819-1832. Epub 2017 Apr 14.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, China

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