Publications

Cystathionine γ-Lyase-Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing.
Antioxid Redox Signal 2017 Oct 10;27(11):742-753. Epub 2017 Mar 10.
1 Hypertension Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases , Beijing, China .

NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.
Diabetes 2017 Jul 14;66(7):1819-1832. Epub 2017 Apr 14.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, China

FAM3A enhances adipogenesis of 3T3-L1 preadipocytes via activation of ATP-P2 receptor-Akt signaling pathway.
Oncotarget 2017 Jul;8(28):45862-45873
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Beijing 100191, China.

FAM3A mediates PPARγ's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress.
Oncotarget 2017 Jul;8(30):49882-49896
Department of Physiology and Pathophysiology, School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China.

Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice.
Diabetes 2017 May 28;66(5):1185-1197. Epub 2017 Feb 28.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, China

Gut microbiota dysbiosis contributes to the development of hypertension.
Microbiome 2017 Feb 1;5(1):14. Epub 2017 Feb 1.
Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.
Circ Res 2016 Jul 5;119(2):261-76. Epub 2016 May 5.
From the Department of Physiology and Pathophysiology (Y.F., C.G., Y.L., M.W., Y.H., T.L., Y.J., F.Y., X.W., W.K.), Department of Biomedical Informatics (W.M., Q.C.), Institute of Cardiovascular Sciences, School of Basic Medical Sciences (Y.L.), Peking University, Beijing, P. R. China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, P. R. China (Y.F., C.G., Y.L., M.W., Y.H., W.M., T.L., Y.J., F.Y., Q.C., Y.L., X.W., W.K.); School of Biological Science and Medical Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing, P. R. China (W.Z.); and Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (Q.X.).

SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features.
Nucleic Acids Res 2016 Jun 20;44(10):e91. Epub 2016 Feb 20.
Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, Beijing 100191, China MOE Key Lab of Molecular Cardiovascular Sciences, Peking University, Beijing 100191, China Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing 100191, China

LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations.
Nucleic Acids Res 2016 May 16;44(9):e90. Epub 2016 Feb 16.
Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China MOE Key Lab of Cardiovascular Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China Beijing Key Laboratory of Tumor Systems Biology, Peking University, 38 Xueyuan Road, Beijing 100191, China

Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.
Biochim Biophys Acta 2016 May 2;1861(5):419-29. Epub 2016 Mar 2.
Department of Physiology and Pathophysiology, Peking University Health Science Center, PR China; Center for Noncoding RNA Medicine, Peking University Health Science Center, PR China; Hypertension Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China. Electronic address:

Comparison Analysis of Dysregulated LncRNA Profile in Mouse Plasma and Liver after Hepatic Ischemia/Reperfusion Injury.
PLoS One 2015 29;10(7):e0133462. Epub 2015 Jul 29.
Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing, 100191, China; MOE Key Lab of Molecular Cardiovascular Science, Peking University, 38 Xueyuan Road, Beijing, 100191, China; Center for Noncoding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.

FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury.
J Mol Cell Cardiol 2014 Sep 23;74:173-82. Epub 2014 May 23.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing 100191, China. Electronic address:

HMDD v2.0: a database for experimentally supported human microRNA and disease associations.
Nucleic Acids Res 2014 Jan 4;42(Database issue):D1070-4. Epub 2013 Nov 4.
Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China and MOE Key Lab of Cardiovascular Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.

Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure.
PLoS One 2013 29;8(10):e77938. Epub 2013 Oct 29.
Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China ; MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing, China.

MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1.
PLoS One 2013 11;8(9):e74504. Epub 2013 Sep 11.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing, China.

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