Publications by authors named "Qinghua Chen"

137 Publications

Effects of Dietary Tea Powder on the Growth Performance, Carcass Traits, and Meat Quality of Tibetan Pig × Bama Miniature Pigs.

Animals (Basel) 2021 Nov 11;11(11). Epub 2021 Nov 11.

Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture Chinese Academy of Sciences, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.

This study was conducted to evaluate the effects of tea powder in diets on the growth performance, meat quality, muscular amino acid, fatty acid profile, and serum biochemical indices of pigs. A total of 120 local Chinese pigs (Tibetan × Bama miniature pigs) were randomly assigned to five treatment groups, each with six pens and four pigs per pen. During a 60-day experiment, these groups of pigs were fed the normal diet and the diet supplemented with 1%, 2%, 4%, and 6% tea powder, respectively. The results showed that the supplementation of tea powder did not affect the growth performance of pigs. However, the dietary tea powder inclusion decreased ( < 0.05) the average fat thickness, total fat, and abdominal fat, and increased ( < 0.05) the total muscle as well. In addition, the dietary 2% tea powder decreased ( < 0.05) the muscle lightness (L*) and yellowness (b*). Compared with the control group, the dietary supplementation with 1%, 2%, and 4% tea powder raised ( < 0.05) the total amino acids (TAA) and essential amino acids (EAA), and dietary 4% and 6% tea powder increased ( < 0.05) the C20:5n3 in the muscle tissue. Furthermore, the serum lipid metabolism-related biochemical indices and mRNA expression levels were improved with the addition of tea powder. These results indicated that dietary tea powder might improve the carcass traits and meat quality of the Chinese native finishing pigs, but it does not affect their growth performance. Tea powder could be fully developed and reasonably applied as a dietary supplement.
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http://dx.doi.org/10.3390/ani11113225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614359PMC
November 2021

Characterization and in vitro assessment of three-dimensional extrusion Mg-Sr codoped SiO-complexed porous microhydroxyapatite whisker scaffolds for biomedical engineering.

Biomed Eng Online 2021 Nov 24;20(1):116. Epub 2021 Nov 24.

Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, 650032, China.

Background: Large bone defects have always been a great challenge for orthopedic surgeons. The use of a good bone substitute obtained by bone tissue engineering (BTE) may be an effective treatment method. Artificial hydroxyapatite, a commonly used bone defect filler, is the main inorganic component of bones. Because of its high brittleness, fragility, and lack of osteogenic active elements, its application is limited. Therefore, its fragility should be reduced, its osteogenic activity should be improved, and a more suitable scaffold should be constructed.

Methods: In this study, a microhydroxyapatite whisker (mHAw) was developed, which was doped with the essential trace active elements Mg and Sr through a low-temperature sintering technique. After being formulated into a slurry, a bionic porous scaffold was manufactured by extrusion molding and freeze drying, and then SiO was used to improve the mechanical properties of the scaffold. The hydrophilicity, pore size, surface morphology, surface roughness, mechanical properties, and release rate of the osteogenic elements of the prepared scaffold were detected and analyzed. In in vitro experiments, Sprague-Dawley (SD) rat bone marrow mesenchymal stem cells (rBMSCs) were cultured on the scaffold to evaluate cytotoxicity, cell proliferation, spreading, and osteogenic differentiation.

Results: Four types of scaffolds were obtained: mHAw-SiO (SHA), Mg-doped mHAw-SiO (SMHA), Sr-doped mHAw-SiO (SSHA), and Mg-Sr codoped mHAw-SiO (SMSHA). SHA was the most hydrophilic (WCA 5°), while SMHA was the least (WCA 8°); SMHA had the smallest pore size (247.40 ± 23.66 μm), while SSHA had the largest (286.20 ± 19.04 μm); SHA had the smallest Young's modulus (122.43 ± 28.79 MPa), while SSHA had the largest (188.44 ± 47.89 MPa); and SHA had the smallest compressive strength (1.72 ± 0.29 MPa), while SMHA had the largest (2.47 ± 0.25 MPa). The osteogenic active elements Si, Mg, and Sr were evenly distributed and could be sustainably released from the scaffolds. None of the scaffolds had cytotoxicity. SMSHA had the highest supporting cell proliferation and spreading rate, and its ability to promote osteogenic differentiation of rBMSCs was also the strongest.

Conclusions: These composite porous scaffolds not only have acceptable physical and chemical properties suitable for BTE but also have higher osteogenic bioactivity and can possibly serve as potential bone repair materials.
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http://dx.doi.org/10.1186/s12938-021-00953-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611959PMC
November 2021

Glycogen accumulation and phase separation drives liver tumor initiation.

Cell 2021 Oct 21;184(22):5559-5576.e19. Epub 2021 Oct 21.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) catalyzing the last step of glycogenolysis is frequently downregulated to augment glucose storage in pre-malignant cells. Accumulated glycogen undergoes liquid-liquid phase separation, which results in the assembly of the Laforin-Mst1/2 complex and consequently sequesters Hippo kinases Mst1/2 in glycogen liquid droplets to relieve their inhibition on Yap. Moreover, G6PC or another glycogenolysis enzyme-liver glycogen phosphorylase (PYGL) deficiency in both human and mice results in glycogen storage disease along with liver enlargement and tumorigenesis in a Yap-dependent manner. Consistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence.
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http://dx.doi.org/10.1016/j.cell.2021.10.001DOI Listing
October 2021

Novel Human Insulin Isoforms and Cα-peptide Product in Islets of Langerhans and Choroid Plexus.

Diabetes 2021 Oct 14. Epub 2021 Oct 14.

Diabetes Study Sections, IRP/NIA/NIH, 251 Bayview Blvd, Baltimore, MD 21224

Human insulin () gene diverged from the ancestral genes of invertebrate and mammalian species millions of years ago. We previously found that mouse insulin gene () isoforms are expressed in brain choroid plexus (ChP) epithelium cells where insulin secretion is regulated by serotonin and not by glucose. We further compared human isoform expression in postmortem ChP and islets of Langerhans. We uncovered novel upstream open reading frame (uORF) isoforms and their protein products. In addition, we found a novel alternatively spliced isoform that translates to a 74-amino acid (AA) proinsulin containing a shorter 19-AA C-peptide sequence, herein designated Cα-peptide. The middle portion of the conventional C-peptide contains β-sheet (GQVEL) and hairpin (GGGPG) motifs that are not present in Cα-peptide. Islet amyloid polypeptide () is not expressed in ChP and its amyloid formation was inhibited by Cα-peptide more efficiently than by C-peptide. Of clinical relevance, the ratio of the 74-AA proinsulin to proconvertase processed Cα-peptide was significantly increased in islets from type 2 diabetes mellitus (T2DM) autopsy donors. Intriguingly, 100 years after the discovery of insulin we found that isoforms are present in ChP from insulin-deficient autopsy donors.
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http://dx.doi.org/10.2337/db21-0198DOI Listing
October 2021

Knowledge of and Compliance with Surviving Sepsis Campaign Guidelines among Anesthesiologists: A Nationwide Survey in China.

J Healthc Eng 2021 22;2021:1877166. Epub 2021 Sep 22.

Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

We aimed to describe anesthesiologists' knowledge of and compliance with the Surviving Sepsis Campaign (SSC) guidelines in the perioperative management of patients with sepsis in China. We designed a questionnaire-based, cross-sectional survey. We sent out online questionnaires during 2019 to evaluate whether anesthesiologists in China were familiar with and applied SSC guidelines in perioperative management. We also compared anesthesiologists' knowledge of and compliance with the guidelines among different levels of hospital. In this study, we obtained 971 responses from anesthesiology departments across China. The survey responses showed that 39.0% of anesthesiologists rated their knowledge of the SSC guidelines as being "very familiar" or at least "somewhat familiar." In total, 68.9% of respondents chose "Initial fluid resuscitation followed by frequent hemodynamic reassessment" as their therapy strategy for patients with septic shock; 62.0% of anesthesiologists chose lactate as a marker of initial resuscitation in clinical practice, and 39.1% thought bundle therapy needed to be started within 1 hour of sepsis diagnosis. A total of 37.1% and 27.1% of respondents chose hydroxyethyl starches and gelatins, respectively, as the preferred fluids for septic shock. As the first choice of vasopressors in patients with sepsis, 727 (74.9%) anesthesiologists chose the correct answer (norepinephrine). Anesthesiologists from tertiary hospitals (class A) had greater familiarity and compliance with the SSC guidelines than those from other hospitals ( < 0.001). In summary, anesthesiologists in China have some knowledge of the SSC guidelines and tend to practice in keeping with these guidelines. However, for some items, anesthesiologists are not up to date with the latest version of the SSC guidelines. The popularity of these guidelines is not homogenous among different levels of hospital. Anesthesiologists must strengthen their knowledge of the SSC guidelines and update their practice in a regular and timely manner, especially in other tertiary and primary hospitals.
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http://dx.doi.org/10.1155/2021/1877166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481065PMC
November 2021

Ecological wetland paradigm drives water source improvement in the stream network of Yangtze River Delta.

J Environ Sci (China) 2021 Dec 27;110:55-72. Epub 2021 Mar 27.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Jiaxing created a precedent using bypass riparian marshes to purify micro-polluted water sources in China. Pond-wetland complex with constructed root channel technology becomes a paradigm which can be analogized as "human-body wetland model" based on bionics or biomimetics. Heterogeneous plant-bed/ditch system with highly active land/water ecotone interfaces, especially meandering boundaries, breeds many biochemical reactions "living areas". Optimization of hydraulic regulation promotes redox environment alternations and wetland treatment efficiency. Here we reported a series of upgrades and performances in Guanjinggang wetland after the Shijiuyang prototype. Morphological reform of plant-bed/ditch system played a vital role. Spatially root channel zone was main force of wetland purification, and temporally the treatment effect was higher in low-temperature seasons indicating non-temperature dependent mechanisms worked. Water pollution comprehensive index improved steadily from IV to III, and comprehensive pollution load was reduced by ca. 40%-60%. Comprehensive evaluation function value further showed the gradients purification effect of the upgraded wetland. Ecological wetlands ameliorated source water quality, and reduced drinking water treatment reagents, thereby bringing about economic benefits. Through wetlands operation, people can see how the micro-polluted surface water becomes clear and clean, so promoting a significant social benefit. As a viable component of urban green space, wetlands could beautify regional eco-environment, freshen the air, increase urban ecological taste, and enhance the eco-environmental protection publicity. Thus, the multifunctional service values and indirect benefits are substantial. Jiaxing ecological wetlands provide a typical paradigm for water pollution remediation in developing countries and plays a leading role in technology engineering radiation effect.
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http://dx.doi.org/10.1016/j.jes.2021.03.015DOI Listing
December 2021

Facile fabrication of WS nanocrystals confined in chlorella-derived N, P co-doped bio-carbon for sodium-ion batteries with ultra-long lifespan.

Dalton Trans 2021 Oct 26;50(41):14745-14752. Epub 2021 Oct 26.

Engineering Research Center of Polymer Green Recycling of Ministry of Education, College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China.

Sodium-ion batteries (SIBs) have been regarded as a promising substitute for lithium-ion batteries but there are still formidable challenges in developing an anode material with adequate lifespan and outstanding rate performance. Transition metal dichalcogenides (TMDs) are promising anode materials for SIBs due to their high theoretical capacities. However, their severe volume expansions and low electronic conductivity impede their practical developments. In addition, the synthesis of energy storage materials from waste biomass has aroused extensive attention. Herein, we synthesize WS nanocrystals embedded in N and P co-doped biochar a facile bio-sorption followed by sulphurization, employing waste chlorella as the adsorbent and bio-reactor. The WS nanocrystals are beneficial for storing more sodium ions and expediting the transportation of sodium ions, thus improving the capacity and reaction kinetics. Chlorella acts as a reactor and not only inhibits the stacking of WS nanocrystals during the synthesis process but also alleviates the mechanical pressure of composite during the charge/discharge process. As a result, the WS/NPC-2 electrode delivers a high specific capacity (436 mA h g at 0.1 A g) and superior rate performance of 311 mA h g at 3 A g for SIBs. It also exhibits excellent stability even up to 6000 cycles at 5 A g, which is one of the optimal long-cycle properties reported for WS-based materials to date.
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http://dx.doi.org/10.1039/d1dt01582fDOI Listing
October 2021

The piRNA pathway is essential for generating functional oocytes in golden hamsters.

Nat Cell Biol 2021 09 6;23(9):1013-1022. Epub 2021 Sep 6.

State Key Laboratory of Reproductive Medicine, Jiangsu Laboratory Animal Center, Jiangsu Animal Experimental Center of Medicine and Pharmacy, Jiangsu Key Laboratory of Xenotransplantation, Department of Cell Biology, Animal Core facility, Key Laboratory of Model Animal, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.

Piwi-interacting RNAs (piRNAs) are predominantly expressed in germ cells and function in gametogenesis in various species. However, Piwi-deficient female mice are fertile and mouse oocytes express a panel of small RNAs that do not appear to be widely representative of mammals. Thus, the function of piRNAs in mammalian oogenesis remains largely unclear. Here, we generated Piwil1- and Mov10l1-deficient golden hamsters and found that all female and male mutants were sterile, with severe defects in embryogenesis and spermatogenesis, respectively. In Piwil1-deficient female hamsters, the oocytes and embryos displayed aberrant transposon accumulation and extensive transcriptomic dysregulation, and the embryos were arrested at the two-cell stage with impaired zygotic genome activation. Moreover, PIWIL1-piRNAs exert a non-redundant function in silencing endogenous retroviruses in the oocytes and embryos. Together, our findings demonstrate that piRNAs are indispensable for generating functional germ cells in golden hamsters and show the value of this model species for piRNA studies in gametogenesis, especially those related to female infertility.
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http://dx.doi.org/10.1038/s41556-021-00750-6DOI Listing
September 2021

Regulative Mechanism of Guanidinoacetic Acid on Skeletal Muscle Development and Its Application Prospects in Animal Husbandry: A Review.

Front Nutr 2021 12;8:714567. Epub 2021 Aug 12.

College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Guanidinoacetic acid is the direct precursor of creatine and its phosphorylated derivative phosphocreatine in the body. It is a safe nutritional supplement that can be used to promote muscle growth and development. Improving the growth performance of livestock and poultry and meat quality is the eternal goal of the animal husbandry, and it is also the common demand of today's society and consumers. A large number of experimental studies have shown that guanidinoacetic acid could improve the growth performance of animals, promote muscle development and improve the health of animals. However, the mechanism of how it affects muscle development needs to be further elucidated. This article discusses the physical and chemical properties of guanidinoacetic acid and its synthesis pathway, explores its mechanism of how it promotes muscle development and growth, and also classifies and summarizes the impact of its application in animal husbandry, providing a scientific basis for this application. In addition, this article also proposes future directions for the development of this substance.
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http://dx.doi.org/10.3389/fnut.2021.714567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387576PMC
August 2021

Endowing Acceptable Mechanical Properties of Segregated Conductive Polymer Composites with Enhanced Filler-Matrix Interfacial Interactions by Incorporating High Specific Surface Area Nanosized Carbon Black.

Nanomaterials (Basel) 2021 Aug 16;11(8). Epub 2021 Aug 16.

College of Environmental Science and Engineering, Fujian Normal University, Fuzhou 350007, China.

Tuning the high properties of segregated conductive polymer materials (CPCs) by incorporating nanoscale carbon fillers has drawn increasing attention in the industry and academy fields, although weak interfacial interaction of matrix-filler is a daunting challenge for high-loading CPCs. Herein, we present a facile and efficient strategy for preparing the segregated conducting ultra-high molecular weight polyethylene (UHMWPE)-based composites with acceptable mechanical properties. The interfacial interactions, mechanical properties, electrical properties and electromagnetic interference (EMI) shielding effectiveness (SE) of the UHMWPE/conducting carbon black (CCB) composites were investigated. The morphological and Raman mapping results showed that UHMWPE/high specific surface area CCB (h-CCB) composites demonstrate an obviously interfacial transition layer and strongly interfacial adhesion, as compared to UHMWPE/low specific surface area CCB (l-CCB) composites. Consequently, the high-loading UHMWPE/h-CCB composite (beyond 10 wt% CCB dosage) exhibits higher strength and elongation at break than the UHMWPE/l-CCB composite. Moreover, due to the formation of a densely stacked h-CCB network under the enhanced filler-matrix interfacial interactions, UHMWPE/h-CCB composite possesses a higher EMI SE than those of UHMWPE/l-CCB composites. The electrical conductivity and EMI SE value of the UHMWPE/h-CCB composite increase sharply with the increasing content of h-CCB. The EMI SE of UHMWPE/h-CCB composite with 10 wt% h-CCB is 22.3 dB at X-band, as four times that of the UHMWPE/l-CCB composite with same l-CCB dosage (5.6 dB). This work will help to manufacture a low-cost and high-performance EMI shielding material for modern electronic systems.
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http://dx.doi.org/10.3390/nano11082074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400817PMC
August 2021

Are We in a De-Globalization Process? The Evidence from Global Trade During 2007-2017.

Glob Chall 2021 Aug 27;5(8):2000096. Epub 2021 May 27.

School of Systems Science Beijing Normal University Beijing 100875 China.

Through the analysis of statistical data, some scholars believe that the globalization of trade is declining, and de-globalization has become a trend, even since the financial crisis in 2008. However, the superficial decline of global trade volume cannot be taken as a corollary of the de-globalization. It needs go deep into the structural analysis, and "globalization or de-globalization" should be discussed by analyzing whether the global trade structure has changed. This paper finds that during 2007-2017, the global trade resistances are clearly classified, and trade resistance in the global community has increased significantly. Second, an expectation maximization (EM) algorithm is applied to divide global trade relations into two categories: intimate trade relations, whose barriers are mainly related to geographical distance; and unfriendly trade relations with high artificial barriers. Third, the trade purity indicator (TPI) is introduced to describe the trade environment of countries, and its evolution indicates after the financial crisis and for quite a long time, the structure of global trade has not changed much. And it shows some deterioration trend and structural adjustment after 2015, which indicates an opportunity for the emergence of de-globalization in such an international environment full of uncertainty and challenges.
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http://dx.doi.org/10.1002/gch2.202000096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335849PMC
August 2021

Investigating the formation of iodinated aromatic disinfection by-products in chlorine/phenol/iodide system.

Sci Total Environ 2021 Nov 20;797:149152. Epub 2021 Jul 20.

Qingdao Engineering Research Center for Rural Environment, College of Resource and Environment, Qingdao Agricultural University, Qingdao 266109, China; State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China.

Iodinated disinfection by-products (DBPs) have been attracting great attention due to their potential high toxicity to human health. Understanding of formation mechanisms and transformation process of iodinated aromatic DBPs during the chlorination of iodide-containing water is crucial. Phenol was therefore chosen as a representative of phenolic compounds to investigate the generation of iodinated aromatic DBPs in a chlorine/phenol/iodide system. The presence of iodide in water could enhance the removal of phenol by chlorine due to higher second order rate constants of HOI with phenol than that of HOCl with phenol. Fourteen kinds of iodinated aromatic DBPs were identified, which were generated from oxidation and electrophilic substitution of phenol by HOCl and HOI. Iodinated phenolic DBPs were sources of iodinated quinone DBPs and chlorinated/iodinated phenolic DBPs. Alkaline condition favored the formation of iodinated phenolic DBPs, while acid condition favored the production of iodinated quinone DBPs. Neutral condition might be the most suitable pH condition to control the formation of iodinated aromatic DBPs. The relative concentration of almost all iodinated aromatic DBPs first increased and then decreased with time, indicating iodinated aromatic DBPs might be further converted into halogenated aliphatic DBPs during the chlorination. This research provides a research basis for the removal of phenol in water.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149152DOI Listing
November 2021

Enhancement of Electromagnetic Interference Shielding Performance and Wear Resistance of the UHMWPE/PP Blend by Constructing a Segregated Hybrid Conductive Carbon Black-Polymer Network.

ACS Omega 2021 Jun 2;6(23):15078-15088. Epub 2021 Jun 2.

College of Environmental Science and Engineering, Fujian Normal University, Fuzhou 350007, Fujian, China.

The low-percolation-threshold conductive networking structure is indispensable for the high performance and functionalization of conductive polymer composites (CPCs). In this work, conductive carbon black (CCB)-reinforced ultrahigh-molecular-weight polyethylene (UHMWPE)/polypropylene (PP) blend with tunable electrical conductivity and good mechanical properties was prepared using a high-speed mechanical mixing method and a compression-molded process. An interconnecting segregated hybrid CCB-polymer network is formed in electrically conductive UHMWPE/PP/CCB (UPC) composites. The UPC composites possess a dense conductive pathway at a low percolation threshold of 0.48 phr. The composite with 3 phr CCB gives an electrical conductivity value of 1.67 × 10 S/cm, 12 orders of magnitude higher than that of the polymeric matrix, suggesting that CCB improves both the electrical conductivity and electromagnetic interference shielding effectiveness (EMI SE) of the composite at the loading fraction over its percolation threshold. The composite with 15 phr CCB presents an absorption-dominated electromagnetic interference shielding effectiveness (EMI SE) as high as 27.29 dB at the X-band. The composite also presents higher tribological properties, mechanical properties, and thermal stability compared to the UP blend. This effort provides a simple and effective way for the mass fabrication of CPC materials with excellent performance.
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http://dx.doi.org/10.1021/acsomega.1c01240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210415PMC
June 2021

The influence of family therapy on psychological stress and social adaptability of depressed patients.

Work 2021 ;69(2):613-624

Department of Neurosurgery, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: with the increase of study and life pressure, the number of depressed college students showed an increasing trend year by year, and the drug treatment alone could not achieve a comprehensive recovery of depression patients, so it was more necessary to pay attention to the spiritual treatment.

Objective: this research aimed to better understand the relationship between college students' depression and life events, social support, psychological pressure, and coping style, and the influence of systematic family therapy on depression degree, psychological stress, and social adaptability of college students with depression.

Methods: in this study, 105 college students with depression were selected as the research object, and healthy college students were taken as the control group. Through questionnaire, the differences in life events, social support, psychological stress, and coping styles between the groups were compared. The correlation between the degree of depression and various variables were analyzed, and the impact path of each variable on depression was analyzed using the path analysis model. Depression patients were then divided into a conventional group treating with conventional medications and an observation group treating with systematic family interventions. Differences in Hamilton Depression Scale-17, (HAMD-17), CPSS, and Social Adaptive Functioning Evaluation (SAFE) scores were compared and analyzed between the two groups before treatment (T1), during the treatment (T2), and after treatment(T3).

Results: there were significant differences in scores of life events, social support, psychological stress, and coping styles between the healthy control group and the depressed patients (P < 0.05). There was an obvious correlation between different depression degrees and life events, social support, psychological stress, and coping styles (P < 0.05). Life events, social support, and psychological stress had a direct and significant impact on depression (0.250, 0.218, and 0.392; P < 0.05), and they also had an indirect and significant impact on depression through coping styles (P < 0.05). The systematic family treatment model could significantly reduce HAMD-17 and CPSS scores (P < 0.05), and significantly improve SAFE scores (P < 0.05).

Conclusions: adverse life events, lack of social support, excessive psychological stress, and negative coping styles can aggravate college students' depression. Systematic family therapy can improve the degree of depression, reduce the psychological stress, and enhance the social adaptability of college students with depression.
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http://dx.doi.org/10.3233/WOR-213503DOI Listing
June 2021

Ectopic Overexpression of Histone H3K4 Methyltransferase CsSDG36 from Tea Plant Decreases Hyperosmotic Stress Tolerance in .

Int J Mol Sci 2021 May 11;22(10). Epub 2021 May 11.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China.

Histone methylation plays an important regulatory role in the drought response of many plants, but its regulatory mechanism in the drought response of the tea plant remains poorly understood. Here, drought stress was shown to induce lower relative water content and significantly downregulate the methylations of histone H3K4 in the tea plant. Based on our previous analysis of the SET Domain Group () gene family, the full-length coding sequence (CDS) of was cloned from the tea cultivar ''. Bioinformatics analysis showed that the open reading frame (ORF) of the gene was 3138 bp, encoding 1045 amino acids and containing the conserved structural domains of PWWP, PHD, SET and PostSET. The CsSDG36 protein showed a close relationship to AtATX4 of the TRX subfamily, with a molecular weight of 118,249.89 Da, and a theoretical isoelectric point of 8.87, belonging to a hydrophilic protein without a transmembrane domain, probably located on the nucleus. The expression of was not detected in the wild type, while it was clearly detected in the over-expression lines of Arabidopsis. Compared with the wild type, the over-expression lines exhibited lower hyperosmotic resistance by accelerating plant water loss, increasing reactive oxygen species (ROS) pressure, and increasing leaf stomatal density. RNA-seq analysis suggested that the overexpression caused the differential expression of genes related to chromatin assembly, microtubule assembly, and leaf stomatal development pathways. qRT-PCR analysis revealed the significant down-regulation of stomatal development-related genes (, , , , , , , , and ) in the overexpression lines. This study provides a novel sight on the function of histone methyltransferase CsSDG36 under drought stress.
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http://dx.doi.org/10.3390/ijms22105064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150943PMC
May 2021

The effects of mindfulness-based stress reduction therapy combined with intensive education on the effectiveness of the care and the awareness rate in patients with arthritis and diabetes.

Am J Transl Res 2021 15;13(4):3190-3197. Epub 2021 Apr 15.

Department of Rheumatology and Immunology/Interventional Diagnosis and Treatment, The Second Affiliated Hospital of Hainan Medical University Haikou 570311, Hainan Province, China.

Objective: To explore the effect of mindfulness-based stress reduction (MBSR) therapy combined with intensive education on the effectiveness of the care and the awareness rate in patients with diabetes and arthritis.

Methods: A total of 94 patients with diabetes and arthritis admitted to our hospital were recruited as the study cohort and randomly divided into two groups, with 47 patients in each group. Both groups underwent routine nursing interventions. The control group underwent an eight-week-long intensive education program, while the observation group was additionally cared for with MBSR for 8 weeks. The two groups were assessed using the Symptom Checklist 90 (SCL-90), the Hamilton Anxiety Scale (HAMA-14), the Hamilton Depression Scale (HAMD-17), the Simple Coping Style Questionnaire (SCSQ), the diabetes specificity quality of life scale (DSQL), and their cortisol levels and awareness/satisfaction rates.

Results: The SCL-90 scores were lower in both groups after 8 weeks of nursing ( < 0.05), and the scores in the observation group were lower than the scores in the control group ( < 0.05). The observation group exhibited lower HAMA-14, HAMD-17, and negative coping scores ( < 0.05) and higher positive coping scores than the control group ( < 0.05). The DSQL scores and the cortisol levels in the observation group at 2, 4, 6, and 8 weeks after the nursing were lower than they were in the control group ( < 0.05). The satisfaction rate with the nursing methods, the nursing effectiveness, and the awareness rate with regard to regular review, knowledge of pathogenesis, and clinical manifestations in the observation group were higher than they were in the control group ( < 0.05).

Conclusion: MBSR therapy combined with intensive education can improve patients' symptoms, reduce their anxiety/depression, improve their coping levels, quality of life, and cortisol levels as well as their satisfaction/awareness rates in diabetic patients with arthritis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129383PMC
April 2021

Effectiveness and safety of ivabradine in the treatment of acute myocardial infarction: a systematic review and meta-analysis.

Ann Palliat Med 2021 Apr;10(4):4523-4531

Department of Internal Medicine, Danzhou People's Hospital, Danzhou, China.

Background: Cardiovascular diseases have become a prominent threat to public health and quality of life. In recent years, some studies have reported that ivabradine can improve the cardiac function and prognosis of patients with acute myocardial infarction (AMI).

Methods: We searched China National Knowledge Infrastructure (CNKI), Wanfang database, Chinese Biomedical Literature (CBM), Chongqing Weipu Chinese Sci-tech Journal Database (VIP), PubMed, Cochrane Library, and EMBASE for randomized controlled trials (RCTs) of ivabradine in the treatment of AMI from January 1980 until December 2020. Each RCT was systematically reviewed.

Results: A total of 7 RCTs with 658 patients were included. Compared with the control group, the heart rate [mean deviation (MD) =-9.20, 95% confidence interval (CI): -13.03 to -5.38, P<0.00001] and brain natriuretic peptide (BNP) (MD =-112.73, 95% CI: -186.12 to -39.35, P=0.003) of patients who received ivabradine combined with conventional standard treatment were significantly lower and left ventricular ejection fraction (LVEF) (MD =3.17, 95% CI: 2.12 to 4.23, P<0.00001) was significantly better. The difference in adverse events was not statistically significant [odds ratio (OR) =2.45, 95% CI: 0.92 to 6.55, P=0.07].

Discussion: Ivabradine combined with β-blockers can reduce the resting heart rate and improve heart function in patients with AMI while not increasing adverse events. However, due to limitations in the number and quality of studies included, our conclusions need to be further confirmed by analyzing more studies.
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http://dx.doi.org/10.21037/apm-21-563DOI Listing
April 2021

Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer.

Nat Commun 2021 05 5;12(1):2536. Epub 2021 May 5.

Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China.

Molecular profiling of circulating extracellular vesicles (EVs) provides a promising noninvasive means to diagnose, monitor, and predict the course of metastatic breast cancer (MBC). However, the analysis of EV protein markers has been confounded by the presence of soluble protein counterparts in peripheral blood. Here we use a rapid, sensitive, and low-cost thermophoretic aptasensor (TAS) to profile cancer-associated protein profiles of plasma EVs without the interference of soluble proteins. We show that the EV signature (a weighted sum of eight EV protein markers) has a high accuracy (91.1 %) for discrimination of MBC, non-metastatic breast cancer (NMBC), and healthy donors (HD). For MBC patients undergoing therapies, the EV signature can accurately monitor the treatment response across the training, validation, and prospective cohorts, and serve as an independent prognostic factor for progression free survival in MBC patients. Together, this work highlights the potential clinical utility of EVs in management of MBC.
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http://dx.doi.org/10.1038/s41467-021-22913-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100127PMC
May 2021

Adsorption-desorption behavior of methylene blue onto aged polyethylene microplastics in aqueous environments.

Mar Pollut Bull 2021 Jun 21;167:112287. Epub 2021 Apr 21.

College of Environmental Science and Engineering, Fujian Key Laboratory of Pollution Control & Resource Reuse, Fuzhou 350007, China; Engineering Research Center of Polymer Green Recycling of Ministry of Education, Fujian Normal University, Fuzhou 350007, China.

In this study, polyethylene microplastics were artificially photoaged by xenon light. Experiments were then performed with methylene blue (MB) dye to compare the changes in the structure, properties, and adsorption-desorption behaviors of the aged and virgin polyethylene microplastics. The results showed that the aged polyethylene microplastics were hydrophilic with oxygen-containing functional groups, which enhanced the adsorption capacity of polyethylene for MB from 0.63 mg·g to 8.12 mg·g. The adsorption isotherms changed from the Henry model (virgin polyethylene microplastics) to the Langmuir model (aged polyethylene microplastics), indicating that the partitioning function was gradually replaced by a single-layer covering during the adsorption process. In addition, 7% and 17.8% of the MB loaded onto the aged polyethylene microplastics was desorbed into water and a simulated intestinal fluid, respectively. These findings reveal that aged polyethylene microplastics can accumulate MB, thus posing potential risks to aqueous environments and biological tissues.
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http://dx.doi.org/10.1016/j.marpolbul.2021.112287DOI Listing
June 2021

Enhanced performance of microbial fuel cells with enriched ferrous iron oxidation microflora at room temperatures.

Bioresour Technol 2021 Jul 24;331:125025. Epub 2021 Mar 24.

Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan; Department of Mechanical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong; College of Engineering, Tunghai University, Taichung 407, Taiwan. Electronic address:

Adding ferric ions (Fe) in catholyte can enhance performance of microbial fuel cells (MFCs). This work adopted biocathode with enriched Fe oxidizing microflora to perform in situ Fe oxidization so the MFC could operate with prolonged period with increased cell open circuit voltage (1037 mV) and maximum power density (71.8 Wm at 154 Am) but with minimal needs for iron replenishment. The Fe-oxidizing microflora was very effective so the Fe/Fe could reach high ratio, which was composed of Acidithiobacillus (73.8%), Acidiphilium (12.1%), Mycobacterium (6.92%), Sulfobacillus (2.66%), Ochrobactrum (1.30%), Alicyclobacillus (0.82%), and other minor species. The membrane transport and cell replication were shown to be their most important metabolic activities. The formation of jarosite and hydronium jarosite by Fe and sulfate led to loss of iron ions, which should be minimized in operation.
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http://dx.doi.org/10.1016/j.biortech.2021.125025DOI Listing
July 2021

Climate network approach reveals the modes of CO concentration to surface air temperature.

Chaos 2021 Mar;31(3):031104

China State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

Increasing atmospheric carbon dioxide (CO) is expected to be the main factor of global warming. The relation between CO concentrations and surface air temperature (SAT) has been found related to Rossby waves based on a multi-layer complex network approach. However, the significant relations between CO and SAT occur in the South Hemisphere that is not that much influenced by human activities may offer not enough information to formulate targeted carbon reduction policies. Here, we address it by removing the effects of the Rossby waves to reconstruct CO concentrations and SAT multi-layer complex network. We uncover that the CO concentrations are strongly associated with the surrounding SAT regions. The influential regions of CO on SAT occur over eastern Asia, West Asia, North Africa, the coast of North American, and Western Europe. It is shown that CO over Siberia in phase with the SAT variability in eastern East Asia. Indeed, CO concentration variability is causing effects on the recent warming of SAT in some middle latitude regions. Furthermore, sensitive parameters that CO impacts SAT of top 15 carbon emissions countries have been identified. These countries are significantly responsible for global warming, giving implications for carbon emissions reductions. The methodology and results presented here not only facilitate further research in regions of increased sensitivity to the warming resulting from CO concentrations but also can formulate strategies and countermeasures for carbon emission and carbon reduction.
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http://dx.doi.org/10.1063/5.0040360DOI Listing
March 2021

Protected Intestinal Integrity, Alleviated Intestinal Oxidative Damage, and Activated Toll-Like Receptor-Bruton's Tyrosine Kinase-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Weaned Piglets Challenged with Lipopolysaccharide.

Antioxidants (Basel) 2021 Mar 16;10(3). Epub 2021 Mar 16.

College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.

Oxidative stress is increasingly being recognized as a player in the pathogenesis of intestinal pathologies, and probiotics are becoming an attractive means of addressing it. The present study investigated the effects of dietary supplementation with (LAB) on intestinal integrity and oxidative damage in lipopolysaccharide (LPS)-challenged piglets. A total of 36 crossbred weaned piglets (Duroc × Landrace × Large Yorkshire) were randomly divided into three groups: (1) non-challenged controls (CON), (2) LPS-challenged controls (LPS), and (3) 0.2% LAB (2.01 × 10 CFU/g) + LPS treatment (LAB + LPS). On the 29th day of the experiment, the LPS and CON groups were injected intraperitoneally with LPS and saline at 100 ug/kg body weight, respectively. The results show that the LPS-induced elevation of the serum diamine oxidase (DAO) level and small intestinal crypt depth (CD) were reversed by the dietary addition of LAB, which also markedly increased the ileal expression of tight junction proteins (occludin, ZO-1, and claudin-1) in the LPS-challenged piglets. Furthermore, LAB supplementation normalized other LPS-induced changes, such as by decreasing malondialdehyde (MDA) in both the serum and intestinal mucosa and 8-hydroxy-2-deoxyguanosine (8-OHdG) in the jejunal mucosa, increasing glutathione reductase (GR) and glutathione peroxidase (GSH-Px) in both the serum and intestinal mucosa, and increasing glutathione (GSH) and superoxide dismutase (SOD) in the jejunal mucosa. LAB also activated Toll-like receptor (TLR)-Bruton's tyrosine kinase (Btk)-nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathways in the intestine, suggesting that it plays a vital role in the ameliorative antioxidant capacity of weaned piglets. In summary, LAB increased intestinal integrity by improving the intestinal structure and tight junctions while enhancing antioxidant functions via the activation of the TLR-Btk-Nrf2 signaling pathway.
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http://dx.doi.org/10.3390/antiox10030468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002333PMC
March 2021

Nitrogen-doped carbon encapsulated zinc vanadate polyhedron engineered from a metal-organic framework as a stable anode for alkali ion batteries.

J Colloid Interface Sci 2021 Jul 9;593:251-265. Epub 2021 Mar 9.

Engineering Research Center of Polymer Green Recycling of Ministry of Education, College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China; Fujian Key Laboratory of Pollution Control & Resource Reuse, Fuzhou, Fujian 350007, China. Electronic address:

In this work, we fabricated vanadium/zinc metal-organic frameworks (V/Zn-MOFs) derived from self-assembled metal organic frameworks, to further disperse ultrasmall ZnVO nanoparticles and encapsulate them in a nitrogen-doped nanocarbon network (ZVO/NC) under in situ pyrolysis. When employed as an anode for lithium-ion batteries, ZVO/NC delivers a high reversible capacity (807 mAh g at 0.5 A g) and excellent rate performance (372 mAh g at 8.0 A g). Meanwhile, when used in sodium-ion batteries, it exhibits long-term cycling stability (7000 cycles with 145 mAh g at 2.0 A g). Additionally, when employed in potassium-ion batteries, it also shows outstanding electrochemical performance with reversible capacities of 264 mAh g at 0.1 A g and 140 mAh g at 0.5 A g for 1000 cycles. The mechanism by which the pseudocapacitive behaviour of ZVO/NC enhances battery performance under a suitable electrolyte was probed, which offers useful enlightenment for the potential development of anodes of alkali-ion batteries. The performance of ZnVO as an anode for SIBs/PIBs was investigated for the first time. This work provides a new horizon in the design ZVO/NC as a promising anode material owing to the intrinsically synergic effects of mixed metal species and the multiple valence states of V.
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http://dx.doi.org/10.1016/j.jcis.2021.02.108DOI Listing
July 2021

Co-construction of sulfur vacancies and carbon confinement in VS/CNFs to induce an ultra-stable performance for half/full sodium-ion and potassium-ion batteries.

Nanoscale 2021 Mar;13(9):5033-5044

Engineering Research Center of Polymer Green Recycling of Ministry of Education, College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, Fujian 35007, China. and Fujian Key Laboratory of Pollution Control & Resource Reuse, Fuzhou, Fujian 350007, China and Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, China.

The construction of anode materials for sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) with a high energy and a long lifespan is significant and still challenging. Here, sulfur-defective vanadium sulfide/carbon fiber composites (D-V5S8/CNFs) are designed and fabricated by a facile electrospinning method, followed by sulfuration treatment. The unique architecture, in which V5S8 nanoparticles are confined inside the carbon fiber, provides a short-range channel and abundant adsorption sites for ion storage. Moreover, enlarged interlayer spacings could also alleviate the volume changes, and offer small vdW interactions and ionic diffusion resistance to store more Na and K ions reversibly and simultaneously. The DFT calculations further demonstrate that sulfur defects can effectively facilitate the adsorption behavior of Na+ and K+ and offer low energy barriers for ion intercalation. Taking advantage of the functional integration of these merits, the D-V5S8/CNF anode exhibits excellent storage performance and long-term cycling stability. It reveals a high capacity of 462 mA h g-1 at a current density of 0.2 A g-1 in SIBs, while it is 350 mA h g-1 at 0.1 A g-1 in PIBs, as well as admirable long-term cycling characteristics (190 mA h g-1/17 000 cycles/5 A g-1 for SIBs and 165 mA h g-1/3000 cycles/1 A g-1 for PIBs). Practically, full SIBs upon pairing with a Na3V2(PO4)3 cathode also exhibit superior performance.
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http://dx.doi.org/10.1039/d0nr08788bDOI Listing
March 2021

Amorphous Boron Dispersed in LaCoO with Large Oxygen Vacancies for Efficient Catalytic Propane Oxidation.

Chemistry 2021 Mar 3;27(14):4738-4745. Epub 2021 Feb 3.

Fujian Key Laboratory of Pollution Control & Resource Reuse, Fujian Normal University, Fuzhou, 350007, P.R. China.

Unsatisfactory oxygen mobility is a considerable barrier to the development of perovskites for low-temperature volatile organic compounds (VOCs) oxidation. This work introduced small amounts of dispersed non-metal boron into the LaCoO crystal through an easy sol-gel method to create more oxygen defects, which are conducive to the catalytic performance of propane (C H ) oxidation. It reveals that moderate addition of boron successfully induces a high distortion of the LaCoO crystal, decreases the perovskite particle size, and produces a large proportion of bulk Co species corresponding to abundant oxygen vacancies. Additionally, surface Co species, as the acid sites, which are active for cleaving the C-H bonds of C H molecules, are enriched. As a result, the LCB-7 (molar ratio of Co/B=0.93:0.07) displays the best C H oxidation activity. Simultaneously, the above catalyst exhibits superior thermal stability against CO and H O, lasting 200 h. This work provides a new strategy for modifying the catalytic VOCs oxidation performance of perovskites by the regulation of amorphous boron dispersion.
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http://dx.doi.org/10.1002/chem.202004848DOI Listing
March 2021

Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation.

J Genet Genomics 2020 10 28;47(10):618-626. Epub 2020 Oct 28.

Experimental and Clinical Research Center (ECRC), A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Lindenberger Weg.80, Berlin, 13125, Germany. Electronic address:

Congenital hearing loss is a common disorder worldwide. Heterogeneous gene variation accounts for approximately 20-25% of such patients. We investigated a five-generation Chinese family with autosomal-dominant nonsyndromic sensorineural hearing loss (SNHL). No wave was detected in the pure-tone audiometry, and the auditory brainstem response was absent in all patients. Computed tomography of the patients, as well as of two sporadic SNHL cases, showed bilateral inner ear anomaly, cochlear maldevelopment, absence of the osseous spiral lamina, and an enlarged vestibular aqueduct. Such findings were absent in nonaffected persons. We used linkage analysis and exome sequencing and uncovered a heterozygous missense mutation in the PI4KB gene (p.Gln121Arg) encoding phosphatidylinositol 4-kinase β (PI4KB) from the patients in this family. In addition, 3 missense PI4KB (p.Val434Gly, p.Glu667Lys, and p.Met739Arg) mutations were identified in five patients with nonsyndromic SNHL from 57 sporadic cases. No such mutations were present within 600 Chinese controls, the 1000 genome project, gnomAD, or similar databases. Depleting pi4kb mRNA expression in zebrafish caused inner ear abnormalities and audiosensory impairment, mimicking the patient phenotypes. Moreover, overexpression of 4 human missense PI4KB mutant mRNAs in zebrafish embryos resulted in impaired hearing function, suggesting dominant-negative effects. Taken together, our results reveal that PI4KB mutations can cause SNHL and inner ear malformation. PI4KB should be included in neonatal deafness screening.
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http://dx.doi.org/10.1016/j.jgg.2020.07.008DOI Listing
October 2020

Boosting total oxidation of propane over [email protected] nanofiber catalysts prepared by multifluidic coaxial electrospinning with continuous grain boundary and fast lattice oxygen mobility.

J Hazard Mater 2021 Mar 2;406:124695. Epub 2020 Dec 2.

Digital Fujian Internet-of-Things Laboratory of Environmental Monitoring, Fujian Normal University, Fuzhou 350007, China; Fuqing Branch of Fujian Normal University, Fuqing 350300, China. Electronic address:

A one-dimensional (1D) core-shell of Co-Ce oxide has been prepared by multifluidic coaxial electrospinning method and evaluated for the total oxidation of propane (CH). Activity and morphological characterizations show that the [email protected] nanofiber catalyst, of which the core is CeO and the shell is CoO, exhibits excellent oxidation activity. The exposed CoO grown on the outside of the fibers can rapidly react with CH while CeO with high oxygen storage capacity in the inside is conductive to the enhanced oxidation rate. Besides, the continuous grain boundary provides a fast mass transfer channel for lattice oxygen, and rich oxygen vacancies favor the mobility of active oxygen species. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTs) confirms that the [email protected] catalyst have a faster rate of CH adsorption and better oxidation activity with respect to the counterpart using a single-needle electrospinning method. Moreover, the [email protected] catalyst displays excellent thermal stability, and strong resistance against 5 vol% HO and 5 vol% CO at both 300 and 400 °C. Our strategy can give some new insights into morphological engineering to promote active oxygen mobility via the construction of one-dimensional core-shell of metal oxides for catalytic oxidation of VOCs.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124695DOI Listing
March 2021

Improving photocatalytic activity by construction of immobilized Z-scheme CdS/Au/TiO nanobelt photocatalyst for eliminating norfloxacin from water.

J Colloid Interface Sci 2021 Mar 26;586:243-256. Epub 2020 Oct 26.

College of Resources and Environment, Qingdao Agricultural University, Qingdao Engineering Research Center for Rural Environment, Qingdao, PR China. Electronic address:

To improve the photocatalytic activity of TiO NBs under irradiation of solar light, an immobilized Z-scheme composite photocatalyst CdS/Au/TiO NBs has been constructed. For the unique architectures, the TiO NBs provide more absorption and reaction sites, the CdS nanoparticles enhance overall light harvesting, and Au acts as the electron transfer mediator, promoting the interfacial charge transfer and efficient separation of electrons and holes. The morphology, elements, crystal structure, optical and photoelectrochemical properties, and photocatalytic activity of CdS/Au/TiO NBs were characterized. Results showed that CdS/Au/TiO NBs possesses higher photocatalytic activity toward the degradation of antibiotic norfloxacin under irradiation of simulated sunlight, which is attributed to the synergetic interaction of increased light absorption and separation of photogenerated electrons and holes. Besides, the degradation of norfloxacin was promoted by HCO, but inhibited by NO and Cl. The radicals trapping experiments proved that superoxide radicals (O) was the dominating active species during the photocatalysis process. The photocatalytic degradation products of norfloxacin was analyzed, and nine intermediates were identified. Moreover, the photocatalytic degradation mechanism and photostability of CdS/Au/TiO NBs were analyzed in detail. The matched energy levels and unique ternary Z-scheme design are the key for improved photocatalytic activity. The deactivation of CdS/Au/TiO NBs after recycles mainly due to the release of CdS by photocorrosion and the loss of deposited Au.
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http://dx.doi.org/10.1016/j.jcis.2020.10.088DOI Listing
March 2021

Quantitative analysis with volume rendering of pathological myopic eyes by high-resolution three-dimensional magnetic resonance imaging.

Medicine (Baltimore) 2020 Oct;99(42):e22685

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Discovering a relationship between axial length and vitreous volume would be helpful since the axial length is easier to measure than magnetic resonance imaging (MRI) parameters. This study aimed to analyze the topography of human eyes with pathological myopia through volume rendering images by high-resolution 3D-MRI and to establish a model to estimate the vitreous volume.This was a retrospective, non-randomized, controlled study of patients evaluated at Tongren Hospital from July 7, 2007 to December 12, 2018. The controls were emmetropic volunteers. All participants underwent ophthalmic examinations. Axial length was measured with an IOL Master. High-resolution 3D MRI and volume rendering was utilized for all the eyes. Logistic regression was used to establish a model to predict the vitreous volume.A total of 280 emmetropic eyes and 290 eyes with pathological myopia were included. Males represented 60.7% and 65.5% of the individuals. The mean axial lengths of those two groups were 23.1 ± 0.8 mm (95%CI: 22.7-23.4 mm) and 28.3 ± 2.2 mm (95%CI: 27.5-29.2 mm), respectively (P < .001). The regression model in the pathological myopic group for calculating the vitreous volume according to the axial length was: Vitreous volume = 546.27 × axial length - 6977.12. The regression model in the emmetropic group for calculating the vitreous volume according to the axial length was: Vitreous volume = 458.35 × axial length - 6331.14 (R = 0.360, P = .001).Elongation of the axial length is involved in eyeball enlargement in pathological myopic eyes. Measurement of the axial length could be recommended for the estimation of the vitreous volume during vitrectomy if vitreous cavity filling is needed.
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http://dx.doi.org/10.1097/MD.0000000000022685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572025PMC
October 2020
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