Biography

Primary Affiliation: National Institutes of Health - Blatimore, MD , United States

Specialties: Neuroscience

Research Interests: Pharmacogenetics

Publications

Expression of functional cannabinoid CB receptor in VTA dopamine neurons in rats.
Addict Biol 2017 May 1;22(3):752-765. Epub 2016 Feb 1.
Neuropsychopharmacology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA.

Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma.
Arthritis Res Ther 2016 May 4;18(1):99. Epub 2016 May 4.
Department of Medicine, Division of Rheumatology, University of California, San Francisco, 513 Parnassus Avenue, Med Sci, S-847, San Francisco, CA, 94143, USA.

Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.
Neuropsychopharmacology 2016 Mar 5;41(4):1024-33. Epub 2015 Aug 5.
Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.


Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
J Neurosci 2015 Apr;35(14):5625-39
Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, and

Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats.
Neuropsychopharmacology 2015 Mar 6;40(4):1037-51. Epub 2014 Nov 6.
Neurobiology of Relapse Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.




Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease.
J Biol Chem 2011 Dec 11;286(52):45093-102. Epub 2011 Nov 11.
Neural Protection and Regeneration Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Social Services, Baltimore, Maryland21224, USA.



Localization and altered expression of nucleophosmin in the nuclear matrix during the differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA.
Cancer Invest 2010 Dec 6;28(10):1004-12. Epub 2010 Aug 6.
The Key Laboratory of Ministry of Education for Cell Biology & Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, PR China.

Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid.
J Cell Biochem 2010 Sep;111(1):67-74
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Science, Xiamen University, Xiamen 361005, PR China.


A human-specific de novo protein-coding gene associated with human brain functions.
PLoS Comput Biol 2010 Mar 26;6(3):e1000734. Epub 2010 Mar 26.
Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China.



Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers.
Mol Med 2009 Jan-Feb;15(1-2):21-7. Epub 2008 Oct 2.
Molecular Neurobiology Branch, National Institutes of Health-Intramural Research Program (National Institute on Drug Abuse), Baltimore, Maryland 21224, United States of America.

Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
Ann N Y Acad Sci 2008 Oct;1141:318-81
Molecular Neurobiology Branch, National Institutes of Health (NIH), Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), Baltimore, MD 21224, USA.


Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation.
Nucleic Acids Res 2008 Sep 24;36(15):4833-44. Epub 2008 Jul 24.
Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, PR China.

Brain-derived neurotrophic factor and obesity in the WAGR syndrome.
N Engl J Med 2008 Aug;359(9):918-27
Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1103, USA.

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Arch Gen Psychiatry 2008 Jun;65(6):683-93
Molecular Neurobiology Research Branch, National Institutes of Health-Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Dr, Ste 3510, Baltimore, MD 21224, USA.


[Localization of prohibitin in nuclear matrix and its expressive alteration during the differentiation of human osteosarcoma MG-63 cells induced by HMBA].
Fen Zi Xi Bao Sheng Wu Xue Bao 2008 Feb;41(1):1-10
The Key Laboratory of China Education Ministry for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China.

"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.
Biochem Pharmacol 2008 Jan 25;75(1):98-111. Epub 2007 Jul 25.
Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, MD 21224, USA.




Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine.
Brain Res 2006 Jan 22;1067(1):1-12. Epub 2005 Dec 22.
Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Department of Health and Human Services (DHHS), Box 5180, Baltimore, MD 21224, USA.

Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.
Proc Natl Acad Sci U S A 2005 Aug 9;102(33):11864-9. Epub 2005 Aug 9.
Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Box 5180, Baltimore, MD 21224, USA.

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.
Am J Med Genet B Neuropsychiatr Genet 2005 Apr;134B(1):93-103
Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Department of Health and Human Services (DHHS), Baltimore, Maryland, USA.

GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.
Biochem J 2004 Jan;377(Pt 1):171-81
Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, NIH, Department of Health and Human Services, Box 5180, Baltimore, MD 21224, USA.


Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin.
Int J Biochem Cell Biol 2008 12;40(9):1918-29. Epub 2008 Feb 12.
Key Laboratory of Ministry of Education for Cell Biology & Tumor cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, PR China.

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