Publications by authors named "Qing Yang"

1,841 Publications

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RSF1 in cancer: interactions and functions.

Cancer Cell Int 2021 Jun 19;21(1):315. Epub 2021 Jun 19.

Department of Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, School of Life Sciences, China Medical University, Shenyang, China.

RSF1, remodelling and spacing factor 1, is an important interphase centromere protein and is overexpressed in many types of cancers and correlated with poor overall survival. RSF1 has functions mainly in maintaining chromosome stability, facilitating DNA repair, maintaining the protein homeostasis of RSF1 and suppressing the transcription of some oncogenes when RSF1 protein is expressed at an optimal level; however, RSF1 overexpression facilitates drug resistance and cell cycle checkpoint inhibition to prompt cancer proliferation and survival. The RSF1 expression level and gene background are crucial for RSF1 functions, which may explain why RSF1 has different functions in different cancer types. This review summarizes the functional domains of RSF1, the overexpression status of RSF1 and SNF2H in cancer based on the TCGA and GTE databases, the cancer-related functions of RSF1 in interacting with H2Aub, HDAC1, CENP-A, PLK1, ATM, CENP-S, SNF2H, HB, BubR1, cyclin E1, CBP and NF-κB and the potential clinical value of RSF1, which will lay a theoretical foundation for the structural biology study of RSF1 and application of RSF1 inhibitors, truncated RSF1 proteins and SNF2H inhibitors in the treatment of RSF1-overexpressing tumours.
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http://dx.doi.org/10.1186/s12935-021-02012-9DOI Listing
June 2021

Study on toxicological effect and the mechanism of cadmium in rice and inorganic cadmium on ICR mice.

Toxicol Res (Camb) 2021 May 1;10(3):639-650. Epub 2021 Jun 1.

Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, Wuhan Polytechnic University, 68 Xuefu South Road, Wuhan 430023, Hubei, China.

Cadmium (Cd) exposure may induce chronic intoxication, but the harm of cadmium in rice to human at chronic low-level Cd exposure remains unclear. This study employed a mouse model to investigate the toxicity and mechanism of cadmium in rice and CdCl. After 8-week exposure to Cd (CdCl and Cd-contaminated rice), the biochemical indicators and oxidation indicators in the serum and liver of mice were determined, and used mRNA sequencing to investigate the mechanism of different forms of Cd. Results showed that the cadmium concentration of the liver in the CdCl + Rice-N group (CdCl mixed with feed and normal rice, 0.4mg/kg.bw) was higher than that in the Rice-H group (0.4mg/kg.bw). However, the cadmium concentration of the kidneys in the Rice-H group was higher than that in the CdCl + Rice-N group. Our study demonstrated that Cd-treated (Cd in rice and CdCl) ICR mice generated obviously tissues injury, such as the increased biochemical studies, the activity of antioxidant enzymes debasement. Simultaneously, our data also indicated that there existed difference of the hepatic toxicity between Cd in rice and CdCl. By means of transcriptomics, we discovered that CdCl and Cd in rice may affect different gene expression at the molecular level. We hope to provide some theoretical basis for the revision of food security standards.
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http://dx.doi.org/10.1093/toxres/tfab043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201557PMC
May 2021

NH-UiO-66 Coated with Two-Dimensional Covalent Organic Frameworks: High Stability and Photocatalytic Activity.

ACS Appl Mater Interfaces 2021 Jun 17. Epub 2021 Jun 17.

College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China.

The poor stability and low catalytic activity of NH-UiO-66 in basic solutions require the reactions to be conducted in acidic solutions, which seriously hinders its potential photocatalytic application. Herein, we report that NH-UiO-66 coated with two-dimensional covalent organic frameworks (COFs) via imine bond connection presents not only high photocatalytic activity but also high stability and adaptability to the solution environment. The NH-UiO-66/COF hybrid material was fabricated through the Schiff base reaction of NH-UiO-66 with 4,4',4″-(1,3,5-triazine-2,4,6-triyl)trianiline (TAPT) and 2,4,6-triformylphloroglucinol (TP). The hybrid material showed high stability in an alkaline environment, with only 4.7% of NH-UiO-66 decomposed after the photocatalytic reaction. The optimum photocatalytic H evolution rate was 8.44 mmol·h·g when triethanolamine was used as an electron-donating agent. The results presented here illustrate the possibility for effectively improving both the photocatalytic performance and stability of NH-UiO-66 by coupling with COFs.
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http://dx.doi.org/10.1021/acsami.1c06008DOI Listing
June 2021

A single-domain small protein Med-ORF10 regulates the production of antitumour agent medermycin in Streptomyces.

Microb Biotechnol 2021 Jun 17. Epub 2021 Jun 17.

Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.

Med-ORF10, a single-domain protein with unknown function encoded by a gene located in a gene cluster responsible for the biosynthesis of a novel antitumour antibiotic medermycin, shares high homology to a group of small proteins widely distributed in many aromatic polyketide antibiotic pathways. This group of proteins contain a nuclear transport factor-2 (NTF-2) domain and appear to undergo an evolutionary divergence in their functions. Gene knockout and interspecies complementation suggested that Med-ORF10 plays a regulatory role in medermycin biosynthetic pathway. Overexpression of med-ORF10 in its wild-type strain led to significant increase of medermycin production. It was also shown by qRT-PCR and Western blot that Med-ORF10 controls the expression of genes encoding tailoring enzymes involved in medermycin biosynthesis. Transcriptome analysis and qRT-PCR revealed that Med-ORF10 has pleiotropic effects on more targets. However, there is no similar conserved domain available in Med-ORF10 compared to those of mechanistically known regulatory proteins; meanwhile, no direct interaction between Med-ORF10 and its target promoter DNA was detected via gel shift assay. All these studies suggest that Med-ORF10 regulates medermycin biosynthesis probably via an indirect mode.
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http://dx.doi.org/10.1111/1751-7915.13834DOI Listing
June 2021

Microbiome-Metabolomics Reveals Endogenous Alterations of Energy Metabolism by the Dushen Tang to Attenuate D-Galactose-Induced Memory Impairment in Rats.

Biomed Res Int 2021 27;2021:6649085. Epub 2021 May 27.

Jilin Provincial Key Laboratory of Biomacromolecules of Chinese Medicine, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130021, China.

Aging affects the brain function in elderly individuals, and Dushen Tang (DST) is widely used for the treatment of senile diseases. In this study, the protective effect of DST against memory impairment was evaluated through the Morris water maze (MWM) test and transmission electron microscopy (TEM). A joint analysis was also performed using LC-MS metabolomics and the microbiome. The MWM test showed that DST could significantly improve the spatial memory and learning abilities of rats with memory impairment, and the TEM analysis showed that DST could reduce neuronal damage in the hippocampus of rats with memory impairment. Ten potential biomarkers involving pyruvate metabolism, the synthesis and degradation of ketone bodies, and other metabolic pathways were identified by the metabolomic analysis, and it was found that 3-hydroxybutyric acid and lactic acid were involved in the activation of cAMP signaling pathways. The 16S rDNA sequencing results showed that DST could regulate the structure of the gut microbiota in rats with memory impairment, and these effects were manifested as changes in energy metabolism. These findings suggest that DST exerts a good therapeutic effect on rats with memory impairment and that this effect might be mainly achieved by improving energy metabolism. These findings might lead to the potential development of DST as a drug for the treatment of rats with memory impairment.
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http://dx.doi.org/10.1155/2021/6649085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175156PMC
May 2021

Two-sided matching based on I-BTM and LSGDM applied to high-level overseas talent and job fit problems.

Sci Rep 2021 Jun 16;11(1):12723. Epub 2021 Jun 16.

College of Law, Civil Aviation University of China, Tianjin, 300300, China.

With the increasing number of overseas talent tasks in China, overseas talent and job fit are significant issues that aim to improve the utilization of this key human resource. Many studies based on fuzzy sets have been conducted on this topic. Among the many fuzzy set methods, intuitionistic fuzzy sets are usually utilized to express and handle the evaluation information. In recent years, various intuitionistic fuzzy decision-making methods have been rapidly developed and used to solve evaluation problems, but none of them can be used to solve the person-job fit problem with intuitionistic best-worst method (BWM) and TOPSIS methods considering large-scale group decision making (LSGDM) and evaluator social network relations (SNRs). Therefore, to solve problems of intuitionistic fuzzy information analysis and the LSGDM for high-level overseas talent and job fit, we construct a new hybrid two-sided matching method named I-BTM and an LSGDM method considering SNRs. On the one hand, to express the decision-making information more objectively and reasonably, we combine the BWM and TOPSIS in an intuitionistic environment. Additionally, we develop the LSGDM with optimized computer algorithms, where the evaluators' attitudes are expressed by hesitant fuzzy language. Finally, we build a model of high-level overseas talent and job fit and establish a mutual criteria system that is applied to a case study to illustrate the efficiency and reasonableness of the model.
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http://dx.doi.org/10.1038/s41598-021-92057-7DOI Listing
June 2021

ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.

Front Pharmacol 2021 28;12:669730. Epub 2021 May 28.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Macrophage polarization and phenotypic switching of smooth muscle cells (SMCs) are multi-faceted events dominating atherosclerosis (AS) progression. TGF-β was proved to been one of the bridge on the crosstalk between macrophage and SMC. ShenLian (SL) was extracted from a potent anti-atherosclerotic formula. However, its exact mechanism rebalancing inflammatory microenvironment of AS remain largely unknown. Within the entirety of macrophage and SMC, this study investigated the pharmacological effects of SL on stabilizing atherosclerotic plaques. The main components of SL were examined by high performance liquid chromatography. Co-culture and conditioned medium models of macrophage/SMC interactions were designed to identify the relationship between macrophage polarization and switching of SMC phenotypes. Flow cytometry, immunofluorescent staining, RT-PCR, western blotting, and ELISA were used to determine the expression of molecules relating to AS progression. An atherosclerosis animal model, established by placing a perivascular collar on the right common carotid artery in ApoE mice, was used to investigate whether TGF-β is the key molecular mediator of SL in crosstalk between macrophage and SMC. Plaque size was defined by nuclear magnetic resonance imaging. Key markers related to phenotypic transformation of macrophage and SMC were determined by immunohistochemical staining. Results revealed that, accompanied by rebalanced M2 macrophage polarization, SL supported SMC phenotypic transformation and functionally reconstruct the ECM of plaques specifically in macrophage-SMC co-cultural model. Molecularly, such activity of SL closely related to the activation of STAT3/SOCS3 pathway. Furthermore, in co-culture system, up-regulation of α-SMA induced by SL could neutralized by 1D11, a TGF-β neutralizing antibody, indicating that SL mediated Macrophage-SMC communication by enhancing TGF-β. In the AS model constructed by ApoE mice, effects of SL on phenotypic transformation of macrophage and SMC has been well verified. Specific blocking of TGF-β largely attenuated the aforementioned effects of SL. Our findings highlighted that TGF-β might be the responsive factor of SL within macrophage and SMC communication. This study revealed that crosstalk between macrophage and SMC forms a holistic entirety promoting atherosclerotic plaque stability.
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http://dx.doi.org/10.3389/fphar.2021.669730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193129PMC
May 2021

Evidence from an fMRI study that dessert-flavored e-cigarettes engage taste-related, but not smoking-related, brain circuitry for female daily smokers.

Exp Clin Psychopharmacol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery.

Regulations limiting the sale of flavored e-cigarette products are controversial for their potential to interfere with e-cigarette use as a cessation aid in addition to curbing youth use. Limited research suggests that flavor might enhance the addictive potential of e-cigarettes; however, the acute effects of flavored aerosols on brain function among humans have not been assessed. The present study aimed to isolate and compare the neural substrates of flavored and unflavored e-cigarette aerosols on brain function among nine female daily smokers. Participants inhaled aerosolized e-liquid with 36 mg/mL of nicotine with and without a strawberry-vanilla flavor while undergoing functional magnetic resonance imaging. We used general linear modeling to compare whole-brain mean neural activation and seed-to-voxel task-based functional connectivity between the flavored and unflavored inhalation runs. Contrary to our hypothesis, the flavored aerosol was associated with weaker activation than the unflavored aerosol in the brain stem and bilateral parietal-temporal-occipital region of the cortex. Instead, the flavor engaged taste-related brain regions while suppressing activation of the neural circuits typically engaged during smoking and nicotine administration. Alternatively, functional connectivity between subcortical dopaminergic brain seeds and cortical brain regions involved in motivation and reward salience were stronger during the flavored compared to unflavored aerosol run. The findings suggest that fruity and dessert-flavored e-cigarettes may dampen the reward experience of aerosol inhalation for smokers who initiate e-cigarette use by inhibiting activation of dopaminergic brain circuits. These preliminary findings may have implications for understanding how regulations on flavored e-cigarettes might impact their use as cessation aids. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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http://dx.doi.org/10.1037/pha0000488DOI Listing
June 2021

Diffusion tensor imaging indices of acute muscle damage are augmented after exercise in peripheral arterial disease.

Eur J Appl Physiol 2021 Jun 9. Epub 2021 Jun 9.

Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA.

Purpose: Although it is known that peripheral arterial disease (PAD) is associated with chronic myopathies, the acute muscular responses to exercise in this population are less clear. This study used diffusion tensor imaging (DTI) to compare acute exercise-related muscle damage between PAD patients and healthy controls.

Methods: Eight PAD patients and seven healthy controls performed graded plantar flexion in the bore of a 3T MRI scanner. Exercise began at 2 kg and increased by 2 kg every 2 min until failure, or completion of 10 min of exercise. DTI images were acquired from the lower leg pre- and post-exercise, and were analyzed for mean diffusivity, fractional anisotropy (FA), and eigenvalues 1-3 (λ) of the medial gastrocnemius (MG) and tibialis anterior (TA).

Results: Results indicated a significant leg by time interaction for mean diffusivity, explained by a significantly greater increase in diffusivity of the MG in the most affected legs of PAD patients (11.1 × 10 ± 0.5 × 10 mm/s vs. 12.7 × 10 ± 1.2 × 10 mm/s at pre and post, respectively, P = 0.02) compared to healthy control subjects (10.8 × 10 ± 0.3 × 10 mm/s vs. 11.2 × 10 ± 0.5 × 10 mm/s at pre and post, respectively, P = 1.0). No significant differences were observed for the TA, or λ (all P ≥ 0.06). Moreover, no reciprocal changes were observed for FA in either group (all P ≥ 0.29).

Conclusion: These data suggest that calf muscle diffusivity increases more in PAD patients compared to controls after exercise. These findings are consistent with the notion that acute exercise results in increased muscle damage in PAD.
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http://dx.doi.org/10.1007/s00421-021-04711-7DOI Listing
June 2021

HybraPD atlas: Towards precise subcortical nuclei segmentation using multimodality medical images in patients with Parkinson disease.

Hum Brain Mapp 2021 Jun 8. Epub 2021 Jun 8.

School of Information Science and Technology, ShanghaiTech University, Shanghai, China.

Human brain atlases are essential for research and surgical treatment of Parkinson's disease (PD). For example, deep brain stimulation for PD often requires human brain atlases for brain structure identification. However, few atlases can provide disease-specific subcortical structures for PD, and most of them are based on T1w and T2w images. In this work, we construct a HybraPD atlas using fused quantitative susceptibility mapping (QSM) and T1w images from 87 patients with PD. The constructed HybraPD atlas provides a series of templates, that is, T1w, GRE magnitude, QSM, R2*, and brain tissue probabilistic maps. Then, we manually delineate a parcellation map with 12 bilateral subcortical nuclei, which are highly related to PD pathology, such as sub-regions in globus pallidus and substantia nigra. Furthermore, we build a whole-brain parcellation map by combining existing cortical parcellation and white-matter segmentation with the proposed subcortical nuclei map. Considering the multimodality of the HybraPD atlas, the segmentation accuracy of each nucleus is evaluated using T1w and QSM templates, respectively. The results show that the HybraPD atlas provides more accurate segmentation than existing atlases. Moreover, we analyze the metabolic difference in subcortical nuclei between PD patients and healthy control subjects by applying the HybraPD atlas to calculate uptake values of contrast agents on positron emission tomography (PET) images. The atlas-based analysis generates accurate disease-related brain nuclei segmentation on PET images. The newly developed HybraPD atlas could serve as an efficient template to study brain pathological alterations in subcortical regions for PD research.
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http://dx.doi.org/10.1002/hbm.25556DOI Listing
June 2021

A Hybrid Feature Selection based Brain Tumor Detection and Segmentation in Multiparametric Magnetic Resonance Imaging.

Med Phys 2021 Jun 5. Epub 2021 Jun 5.

School of Sport and Health Sciences, Xi'an Physical Education University, Xi'an, 710068, China.

Purpose: To develop a novel method based on feature selection, combining convolutional neural network (CNN) and ensemble learning (EL), to achieve high accuracy and efficiency of glioma detection and segmentation using multiparametric MRIs.

Methods: We proposed an evolutionary feature selection-based hybrid approach for glioma detection and segmentation on 4 MR sequences (T2-FLAIR, T1, T1Gd, and T2). First, we trained a lightweight CNN to detect glioma and mask the suspected region to process large batch of MRI images. Second, we employed a differential evolution algorithm to search a feature space, which composed of 416-dimensions radiomics features extracted from 4 sequences of MRIs and 128-dimensions high-order features extracted by the CNN, to generate an optimal feature combination for pixel classification. Finally, we trained an EL classifier using the optimal feature combination to segment whole tumor (WT) and its subregions including non-enhancing tumor (NET), peritumoral edema (ED), and enhancing tumor (ET) in the suspected region. Experiments were carried out on 300 glioma patients from the BraTS2019 dataset using 5-fold cross-validation, the model was independently validated using the rest 35 patients from the same database.

Results: The approach achieved a detection accuracy of 98.8% using four MRIs. The Dice coefficients (and standard deviations) were 0.852±0.057, 0.844±0.046, and 0.799±0.053 for segmentation of WT (NET+ET+ED), tumor core (NET+ET), and ET, respectively. The sensitivities and specificities were 0.873±0.074, 0.863±0.072, and 0.852±0.082; the specificities were 0.994±0.005, 0.994±0.005, and 0.995±0.004 for the WT, tumor core and ET, respectively. The performances and calculation times were compared with the state-of-the-art approaches, our approach yielded a better overall performance with average processing time of 139.5 sec per set of four sequence MRIs.

Conclusions: We demonstrated a robust and computational cost-effective hybrid segmentation approach for glioma and its subregions on multi-sequence MR images. The proposed approach can be used for automated target delineation for glioma patients.
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http://dx.doi.org/10.1002/mp.15026DOI Listing
June 2021

Occurrence and removal of antibiotics, antibiotic resistance genes, and bacterial communities in hospital wastewater.

Environ Sci Pollut Res Int 2021 Jun 4. Epub 2021 Jun 4.

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Hospital wastewater contains a variety of human antibiotics and pathogens, which makes the treatment of hospital wastewater essential. However, there is a lack of research on these pollutants at hospital wastewater treatment plants. In this study, the characteristics and removal of antibiotics and antibiotic resistance genes (ARGs) in the independent treatment processes of hospitals of different scales (primary hospital, H1; secondary hospital, H2; and tertiary hospital, H3) were investigated. The occurrence of antibiotics and ARGs in wastewater from three hospitals varied greatly. The first-generation cephalosporin cefradine was detected at a concentration of 2.38 μg/L in untreated wastewater from H1, while the fourth-generation cephalosporin cefepime had the highest concentration, 540.39 μg/L, at H3. Ofloxacin was detected at a frequency of 100% and had removal efficiencies of 44.2%, 51.5%, and 81.6% at H1, H2, and H3, respectively. The highest relative abundances of the β-lactam resistance gene bla (1.77×10 copies/16S rRNA), the quinolone resistance gene qnrA (8.81×10 copies/16S rRNA), and the integron intI1 (1.86×10 copies/16S rRNA) were detected in the treated wastewater. The concentrations of several ARGs were increased in the treated wastewater (e.g. bla, bla, and bla). Several pathogenic or opportunistic bacteria (e.g. Acinetobacter, Klebsiella, Aeromonas, and Pseudomonas) were observed at high relative abundances in the treated wastewater. These results suggested the co-occurrence of antibiotics, ARGs, and antibiotic-resistant pathogens in hospital wastewater, and these factors may spread into the receiving aquatic environment.
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http://dx.doi.org/10.1007/s11356-021-14735-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177822PMC
June 2021

Structure-based virtual screening of highly potent inhibitors of the nematode chitinase Cht1.

J Enzyme Inhib Med Chem 2021 Dec;36(1):1198-1204

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Nematode chitinases play vital roles in various physiological processes, including egg hatching, larva moulting, and reproduction. Small-molecule inhibitors of nematode chitinases have potential applications for controlling nematode pests. On the basis of the crystal structure of Cht1, a representative chitinase indispensable to the eggshell chitin degradation of the model nematode , we have discovered a series of novel inhibitors bearing a ()-3,4-diphenyl-4,5-dihydropyrrolo[3,4-]pyrazol-6(2)-one scaffold by hierarchical virtual screening. The crystal structures of Cht1 complexed with two of these inhibitors clearly elucidated their interactions with the enzyme active site. Based on the inhibitory mechanism, several analogues with improved inhibitory activities were identified, among which the compound exhibited the most potent activity with a value of 0.18 μM. This work provides the structural basis for the development of novel nematode chitinase inhibitors.
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http://dx.doi.org/10.1080/14756366.2021.1931862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174485PMC
December 2021

GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B.

J Cell Mol Med 2021 May 28. Epub 2021 May 28.

Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China.

Asthma is a serious public health problem worldwide, without effective therapeutic methods. Our previous study indicated that glucocorticoid-induced transcript 1 gene (GLCCI1) knockout reduces the sensitivity to glucocorticoid in asthmatic mouse. Here, we explored the role and action mechanism of GLCCI1 in asthma development. In ovalbumin-sensitized mice, airway resistance and tissue damage increased, the production of inflammatory cytokines were up-regulated, GLCCI1 expression was reduced and autophagy was activated. Increasing of GLCCI1 inhibited human and mouse airway epithelial cell (AEC) autophagy, while decreasing of GLCCI1 promoted autophagy. Furthermore, we found that GLCCI1 bound with WD repeat domain 45B (WDR45B) and inhibited its expression. Increasing of WDR45B partly reversed the inhibition of GLCCI1 to autophagy-related proteins expression and autophagosome formation in vitro. Increasing of WDR45B in vivo reversed the improvement of GLCCI1 on airway remodelling in asthma and the inhibition to autophagy level in lung tissues. Overall, our data showed that GLCCI1 improved airway remodelling in ovalbumin-sensitized mice through inhibiting autophagy via combination with WDR45B and inhibiting its expression. Our results proved a new idea for asthma treatment.
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http://dx.doi.org/10.1111/jcmm.16658DOI Listing
May 2021

Topologically Protected Transport of Cargo in a Chiral Active Fluid Aided by Odd-Viscosity-Enhanced Depletion Interactions.

Phys Rev Lett 2021 May;126(19):198001

Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.

The discovery of topological edge states that unidirectionally propagate along the boundary of system without backscattering has enabled the development of new design principles for material or information transport. Here, we show that the topological edge flow supported by the chiral active fluid composed of spinners can even robustly transport an immersed intruder with the aid of the spinner-mediated depletion interaction between the intruder and boundary. Importantly, the effective interaction significantly depends on the dissipationless odd viscosity of the chiral active fluid, which originates from the spinning-induced breaking of time-reversal and parity symmetries, rendering the transport controllable. Our findings propose a novel avenue for robust cargo transport and could open a range of new possibilities throughout biological and microfluidic systems.
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http://dx.doi.org/10.1103/PhysRevLett.126.198001DOI Listing
May 2021

Emergence of transferable ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae due to a novel CMY AmpC β-lactamase in China.

Clin Microbiol Infect 2021 May 24. Epub 2021 May 24.

Department of Respiratory Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Objectives: To evaluate the molecular mechanisms of ceftazidime/avibactam (CAZ/AVI) resistance in six Klebsiella pneumoniae that co-producing K. pneumoniae carbapenemase (KPC)-2 and a novel variant of CMY cephalosporinase in a Chinese hospital.

Methods: Antimicrobial susceptibility was determined by broth microdilution. Whole genomic sequencing (WGS) was performed to investigate potential resistant determinants. Plasmid conjugation, electroporation, S1-PFGE hybridization and cloning experiment were carried out to investigate the resistant plasmids and genes.

Results: A high-level of CAZ/AVI resistance was observed in six KPC-Kp strains (MIC=128 mg/L). Five strains were isolated in 2015 and one in 2016, before the approval of CAZ/AVI in China. Sequence analysis indicated all the strains belonged to sequence type (ST) 11 and uniformly carried a novel CMY AmpC β-lactamase gene, designated bla. When compared with CMY-2, CMY-172 owns a deletion of three consecutive amino acids (K290, V291 and A292) in the R2-loop region and a non-synonymous amino acid substitution at position 346 (NI). The bla-bearing plasmid, pKPCZA02_4, was size of 93.3 Kb, IncI1-I type and conjugative. bla located in an IS1294-mediated transposon. Plasmid conjugation and DNA fragment cloning proved bla was responsible for CAZ/AVI resistance.

Conclusions: Our study identified conjugative plasmid-mediated bla as a new mechanism for CAZ/AVI resistance in clinical KPC-Kp strains. Careful monitoring of CAZ/AVI susceptibility is imperative for preventing spread of the resistant gene.
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http://dx.doi.org/10.1016/j.cmi.2021.05.026DOI Listing
May 2021

Identification of Symptom Clusters Among Midlife Menopausal Women with Metabolic Syndrome.

West J Nurs Res 2021 May 27:1939459211018824. Epub 2021 May 27.

School of Nursing, Duke University, Durham, NC, USA.

The aim of this study was to identify and compare symptom clusters in midlife menopausal women with and without metabolic syndrome based on symptom occurrence and severity dimension through secondary data analysis of the Study of Women's Health Across the Nation. Exploratory factor analysis was used to group symptoms that are highly correlated with each other and verified by confirmatory factor analysis. Midlife menopausal women with metabolic syndrome (n = 424) experienced mental health, vasomotor, and somatic cluster across both symptom dimensions. In contrast, midlife menopausal women without metabolic syndrome (n = 1022) experienced mental health/sleep/urinary, vasomotor, and somatic cluster for symptom occurrence dimension and mental health/sleep, vasomotor/genital, and somatic cluster for symptom severity dimension. This is the first study to identify symptom clusters in midlife menopausal women with metabolic syndrome, who are at risk for experiencing complex symptoms associated with menopause transition and metabolic syndrome, and to compare symptom clusters to those without metabolic syndrome.
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http://dx.doi.org/10.1177/01939459211018824DOI Listing
May 2021

Comprehensive influence of topological location and neighbor information on identifying influential nodes in complex networks.

PLoS One 2021 21;16(5):e0251208. Epub 2021 May 21.

School of Management, Wuhan University of Technology, Wuhan, China.

Identifying the influential nodes of complex networks is now seen as essential for optimizing the network structure or efficiently disseminating information through networks. Most of the available methods determine the spreading capability of nodes based on their topological locations or the neighbor information, the degree of node is usually used to denote the neighbor information, and the k-shell is used to denote the locations of nodes, However, k-shell does not provide enough information about the topological connections and position information of the nodes. In this work, a new hybrid method is proposed to identify highly influential spreaders by not only considering the topological location of the node but also the neighbor information. The percentage of triangle structures is employed to measure both the connections among the neighbor nodes and the location of nodes, the contact distance is also taken into consideration to distinguish the interaction influence by different step neighbors. The comparison between our proposed method and some well-known centralities indicates that the proposed measure is more highly correlated with the real spreading process, Furthermore, another comprehensive experiment shows that the top nodes removed according to the proposed method are relatively quick to destroy the network than other compared semi-local measures. Our results may provide further insights into identifying influential individuals according to the structure of the networks.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139458PMC
May 2021

Water/gas separation based on the selective bubble-passage effect of underwater superaerophobic and superaerophilic meshes processed by a femtosecond laser.

Nanoscale 2021 Jun;13(23):10414-10424

State Key Laboratory for Manufacturing System Engineering and Shaanxi Key Laboratory of Photonics Technology for Information, School of Electronic Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China.

To solve the problems caused by tiny bubbles in liquids and the difficulties involved in collecting useful gas underwater, this paper proposes a method to separate bubbles from water by integrating underwater superaerophobic and superaerophilic porous membranes, including bubble removal and collection methods. Inspired by fish scales and lotus leaves, underwater superaerophobic microstructures and underwater superaerophilic microstructures are prepared on a stainless steel (SS) mesh by femtosecond laser processing, respectively. The as-prepared underwater superaerophobic mesh has an anti-bubble ability, while the underwater superaerophilic mesh has a bubble-absorption ability in water. Based on the different dynamic behavior of bubbles on these two kinds of superwetting meshes, efficient water/bubble separation is achieved by using laser-induced superwetting meshes. Tiny bubbles can be completely removed from the water flow in a pipe or easily collected. Such water/gas separation methods based on underwater superaerophobic and superaerophilic porous membranes provide an effective way to prevent the damage caused by bubbles and to collect the available gas in liquids, which has great potential applications in energy utilization, environmental protection, medical and health care, microfluidic chips, chemical manufacturing, agricultural breeding, and so on.
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http://dx.doi.org/10.1039/d1nr01225hDOI Listing
June 2021

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma.

Cell Death Dis 2021 May 19;12(6):511. Epub 2021 May 19.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However, the relationship between MYCN and cell death remains elusive. Ferroptosis is a newly identified cell death mode featured by lipid peroxide accumulation that can be attenuated by GPX4, yet whether and how MYCN regulates ferroptosis are not fully understood. Here, we report that MYCN-amplified NB cells are sensitive to GPX4-targeting ferroptosis inducers. Mechanically, MYCN expression reprograms the cellular iron metabolism by upregulating the expression of TFRC, which encodes transferrin receptor 1 as a key iron transporter on the cell membrane. Further, the increased iron uptake promotes the accumulation of labile iron pool, leading to enhanced lipid peroxide production. Consistently, TFRC overexpression in NB cells also induces selective sensitivity to GPX4 inhibition and ferroptosis. Moreover, we found that MYCN fails to alter the general lipid metabolism and the amount of cystine imported by System X(-) for glutathione synthesis, both of which contribute to ferroptosis in alternative contexts. In conclusion, NB cells harboring MYCN amplification are prone to undergo ferroptosis conferred by TFRC upregulation, suggesting that GPX4-targeting ferroptosis inducers or TFRC agonists can be potential strategies in treating MYCN-amplified NB.
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http://dx.doi.org/10.1038/s41419-021-03790-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134466PMC
May 2021

shrunken4 is a mutant allele of ZmYSL2 that affects aleurone development and starch synthesis in maize.

Genetics 2021 May 1. Epub 2021 May 1.

State Key Laboratory of Plant Physiology and Biochemistry, National Maize Improvement Center, Beijing Key Laboratory of Crop Genetic Improvement, Joint International Research Laboratory of Crop Molecular Breeding, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

Minerals are stored in the aleurone layer and embryo during maize seed development, but how they affect endosperm development and activity is unclear. Here, we cloned the gene underlying the classic maize kernel mutant shrunken4 (sh4) and found that it encodes the YELLOW STRIPE-LIKE oligopeptide metal transporter ZmYSL2. sh4 kernels had a shrunken phenotype with developmental defects in the aleurone layer and starchy endosperm cells. ZmYSL2 showed iron and zinc transporter activity in Xenopus laevis oocytes. Analysis using a specific antibody indicated that ZmYSL2 predominately accumulated in the aleurone and sub-aleurone layers in endosperm and the scutellum in embryos. Specific iron deposition was observed in the aleurone layer in wild-type kernels. In sh4, however, the outermost monolayer of endosperm cells failed to accumulate iron and lost aleurone cell characteristics, indicating that proper functioning of ZmYSL2 and iron accumulation are essential for aleurone cell development. Transcriptome analysis of sh4 endosperm revealed that loss of ZmYSL2 function affects the expression of genes involved in starch synthesis and degradation processes, which is consistent with the delayed development and premature degradation of starch grains in sh4 kernels. Therefore, ZmYSL2 is critical for aleurone cell development and starchy endosperm cell activity during maize seed development.
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http://dx.doi.org/10.1093/genetics/iyab070DOI Listing
May 2021

shrunken4 is a mutant allele of ZmYSL2 that affects aleurone development and starch synthesis in maize.

Genetics 2021 May 1. Epub 2021 May 1.

State Key Laboratory of Plant Physiology and Biochemistry, National Maize Improvement Center, Beijing Key Laboratory of Crop Genetic Improvement, Joint International Research Laboratory of Crop Molecular Breeding, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

Minerals are stored in the aleurone layer and embryo during maize seed development, but how they affect endosperm development and activity is unclear. Here, we cloned the gene underlying the classic maize kernel mutant shrunken4 (sh4) and found that it encodes the YELLOW STRIPE-LIKE oligopeptide metal transporter ZmYSL2. sh4 kernels had a shrunken phenotype with developmental defects in the aleurone layer and starchy endosperm cells. ZmYSL2 showed iron and zinc transporter activity in Xenopus laevis oocytes. Analysis using a specific antibody indicated that ZmYSL2 predominately accumulated in the aleurone and sub-aleurone layers in endosperm and the scutellum in embryos. Specific iron deposition was observed in the aleurone layer in wild-type kernels. In sh4, however, the outermost monolayer of endosperm cells failed to accumulate iron and lost aleurone cell characteristics, indicating that proper functioning of ZmYSL2 and iron accumulation are essential for aleurone cell development. Transcriptome analysis of sh4 endosperm revealed that loss of ZmYSL2 function affects the expression of genes involved in starch synthesis and degradation processes, which is consistent with the delayed development and premature degradation of starch grains in sh4 kernels. Therefore, ZmYSL2 is critical for aleurone cell development and starchy endosperm cell activity during maize seed development.
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http://dx.doi.org/10.1093/genetics/iyab070DOI Listing
May 2021

New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants.

BMC Nephrol 2021 May 17;22(1):181. Epub 2021 May 17.

Department of Rheumatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, China.

Background: The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonephritis (APN) in infants.

Methods: A total of 79 children with APN admitted to our hospital from June 2016 to Jan 2019 were enrolled, including 52 boys and 27 girls, age range 1 month to 3 years old. All cases followed the diagnostic criteria for acute pyelonephritis and excluded anatomical abnormalities of urinary system. All 79 patients were examined by urinary ultrasonography (US), CPDS, and DMSA within 48 h of fever and analyzed the clinical value of combining the two methods in the assessment of APN in infants.

Results: Among 79 children, urinary ultrasonography revealed 2 cases of renal cortical echo changes, both located in the upper pole of the kidney, 24 cases of kidney enlargement, and 1 case of left kidney shrinkage. Ninety-five kidneys were shown to be diseased with DMSA, while 105 kidneys abnormal by CPDS. The sensitivity of CPDS was 69.4%, and the specificity was 38.1%. In children younger than 6 months, the sensitivity of CPDS was 56.9%, which was 84.2% in childeren between 6 months to 1 year, and 94.4% from 1 to 3 years old, respectively. The corresponding specificity of CPDS was 44.1, 26.7, and 35.7%. There was no significant correlation between CPDS levels and DMSA positive results. The abnormal rate of intermediate part in the kidneys was significantly lower than that in the upper and lower poles. Children with abnormal CPDS have a greater risk of renal scarring(p < 0.05).

Conclusion: Abnormalities detected by CPDS in a cohort of infants with APN poorly correlated with DMSA findings. But the sensitivity of CPDS is highly age-related, it can be used as a non-invasive helpful tool for early diagnosis of acute pyelonephritis in infants older than 6 months old.
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http://dx.doi.org/10.1186/s12882-021-02390-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130442PMC
May 2021

Regioselective C-H Phosphorothiolation of (Hetero)arenes Enabled by the Synergy of Electrooxidation and Ultrasonic Irradiation.

Org Lett 2021 Jun 13;23(11):4214-4218. Epub 2021 May 13.

Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.

An electrochemically regioselective C-H phosphorothiolation of (hetero)arenes with thiocyanate as the S source under ultrasonic irradiation has been developed. The synergistic cooperation of electrooxidation and ultrasonication markedly accelerated the C-H phosphorothiolation reaction. This mechanistically different method is distinguished by its wide substrate scope and transition-metal-free and external-oxidant-free conditions, thus complementing the existing metal-catalyzed or peroxide-mediated protocols for the green synthesis of -(hetero)aryl phosphorothioates.
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http://dx.doi.org/10.1021/acs.orglett.1c01161DOI Listing
June 2021

Usability of a Novel Instrument to Measure Damaged Peristomal Skin in Patients with an Ostomy.

Adv Skin Wound Care 2021 Jun;34(6):309-312

At the Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Hui Yang, MM, RN, WT, is Head Nurse, Lecturer, and Wound Therapist, Gastrointestinal Surgery Center; Xinyue Zhao, RN, WOCN, is Wound Ostomy and Continence Nurse, Gastrointestinal Surgery Center; Qing Yang, PhD, is Deputy Director, Nursing Department; and Qinghua Jiang, RN, is Director, Nursing Department. Acknowledgments: This research was supported by Sichuan Province Science and Technology Support Program (no. 2019YFS0387) and Health and Family Planning Commission of Sichuan Province (no. 19PJ141). The authors have disclosed no other financial relationships related to this article. Submitted July 8, 2020; accepted in revised form October 22, 2020.

Objective: To evaluate the usability of a novel instrument (stoma ruler) to measure damaged peristomal skin in patients with an ostomy.

Methods: A wound ostomy and continence nurse used both the stoma ruler and a linear ruler to assess DET (discoloration, erosion, tissue overgrowth) scores and the height of protrusion above the skin of 10 patients with ileostomies and took photographs. The photographs were presented to five ostomy care nurses for reliability testing. The difference between the two methods was determined using paired Wilcoxon signed ranks test.

Primary Outcome Measure: Interrater reliability of the linear versus stoma ruler.

Results: The interrater reliabilities of the stoma ruler versus the linear ruler for the domain-area DET score were 0.95 (95% confidence interval, 0.89-0.99) and 0.68 (95% confidence interval, 0.42-0.89), respectively. Only nurse 5 reported a significant difference between the two rulers (z = -2.24, P = .03).

Conclusions: In busy clinical settings, the stoma ruler is easy for ostomy care nurses to use to obtain accurate DET scores and the height of stoma protrusion above the skin. Observing the position of damaged skin using the clock marks on the stoma ruler enhance clinical description and reduce assessment variation among professionals.
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http://dx.doi.org/10.1097/01.ASW.0000744336.73981.8fDOI Listing
June 2021

Ultrasensitive Vibrational Imaging of Retinoids by Visible Preresonance Stimulated Raman Scattering Microscopy.

Adv Sci (Weinh) 2021 05 8;8(9):2003136. Epub 2021 Feb 8.

Department of Biomedical Engineering Boston University Boston MA 02215 USA.

High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted for retinoid molecules to 34 micromolar via electronic preresonance in the visible wavelength regime. Retinoids play critical roles in development, immunity, stem cell differentiation, and lipid metabolism. By visible preresonance SRS (VP-SRS) imaging, retinoid distribution in single embryonic neurons and mouse brain tissues is mapped, retinoid storage in chemoresistant pancreatic and ovarian cancers is revealed, and retinoids stored in protein network and lipid droplets of are identified. These results demonstrate VP-SRS microscopy as an ultrasensitive label-free chemical imaging tool and collectively open new opportunities of understanding the function of retinoids in biological systems.
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http://dx.doi.org/10.1002/advs.202003136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097318PMC
May 2021

Symptom Trajectory among Formerly Abused Women: An Exploratory Study.

Issues Ment Health Nurs 2021 May 11:1-15. Epub 2021 May 11.

School of Nursing, Duke University School of Nursing, Durham, North Carolina, USA.

Women who have experienced intimate partner violence suffer from symptoms that persist long after the abuse has ended. However, the patterns and trajectory of these symptoms are poorly understood. The objective of this longitudinal research was to explore symptom trajectory typologies. A latent class growth analysis with multi-outcomes modeling was used to explore typologies based on women's ( = 30) trajectories over 4 months. Two distinct symptom typologies were identified: (1) consistently lessening symptom group ( = 16); (2) moderately worsening symptom group ( = 14). Women who experienced severe psychological vulnerability exhibited better symptom trajectories; a potential reflection of resilience in this population.
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http://dx.doi.org/10.1080/01612840.2021.1919806DOI Listing
May 2021

Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities.

Proc Natl Acad Sci U S A 2021 05;118(21)

BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303;

We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using qRT-PCR. All samples were collected from individuals who reported no symptoms associated with COVID-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously observed in symptomatic individuals. Regardless of symptomatic status, ∼50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the disease, based on having low viral loads in a range from which live virus has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral "supercarriers" and possibly also superspreaders.
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http://dx.doi.org/10.1073/pnas.2104547118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166196PMC
May 2021

Rock-Salt MnSSe Nanocubes Assembled on N-Doped Graphene Forming van der Waals Heterostructured Hybrids as High-Performance Anode for Lithium- and Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2021 May 10;13(19):22608-22620. Epub 2021 May 10.

Manganese-based chalcogenides would be of latent capacity in serving as anodes for assembling lithium- and/or sodium-ion batteries (LIBs/SIBs) due to their large theoretical capacity, low price, and low-toxicity functionality, while the low electroconductivity and easy agglomeration behavior may impede their technical applications. Here, a solid-state solution of MnSSe nanocubes in rock-salt phase has been synthesized for the first time at a relatively low temperature from the precursors of Mn(II) acetylacetonate with dibenzyl dichalcogens in oleylamine with octadecene, and the MnSSe nanocubes have been assembled with N-doped graphene to form a new kind of heterostructured nanohybrids (shortened as MnSSe/N-G hybrids), which are very potential for the fabrication of metal-ion batteries including LIBs and/or SIBs. Investigations revealed that there have been dense vacancies generated and active sites increased via nonequilibrium alloying of MnS and MnSe into the solid-solution MnSSe nanocubes with segregation and defects achieved in the low-temperature solution synthetic route. Meanwhile, the introduction of N-doped graphene forming heterojunction interfaces between MnSSe and N-doped graphene would efficiently enhance their electroconductivity and avoid agglomeration of the active MnSSe nanocubes with considerably improved electrochemical properties. As a result, the MnSSe/N-G hybrids delivered superior Li/Na storage capacities with outstanding rate performance as well as satisfactorily lasting stability (1039/457 mA h g at 0.1 A g for LIBs/SIBs). Additionally, full-cell LIBs of the anodic MnSSe/N-G constructed with cathodic LiFePO (LFP) further confirmed the promising future for their practical application.
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http://dx.doi.org/10.1021/acsami.1c04776DOI Listing
May 2021

Correction to: SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA.

Cell Mol Immunol 2021 Jun;18(6):1613-1614

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Medical Research Institute, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1038/s41423-021-00682-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167123PMC
June 2021