Qing K Wang

Qing K Wang

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Qing K Wang

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Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging.

Front Physiol 2019 19;10:1226. Epub 2019 Sep 19.

Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China.

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http://dx.doi.org/10.3389/fphys.2019.01226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761282PMC
September 2019

Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.

Mol Genet Genomics 2019 Aug 17;294(4):1059-1071. Epub 2019 Apr 17.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.

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http://dx.doi.org/10.1007/s00438-019-01567-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812521PMC
August 2019

Mutation in causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model.

FASEB J 2019 Aug 29;33(8):8878-8891. Epub 2019 Apr 29.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1096/fj.201802455RRRDOI Listing
August 2019

Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice.

Diabetes 2019 Aug 15;68(8):1635-1648. Epub 2019 May 15.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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http://dx.doi.org/10.2337/db18-1178DOI Listing
August 2019

Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation.

Ann Hum Genet 2019 Jul 1;83(4):239-248. Epub 2019 Mar 1.

The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1111/ahg.12305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815221PMC
July 2019

Identification of a p.Trp403* nonsense variant in PHEX causing X-linked hypophosphatemia by inhibiting p38 MAPK signaling.

Hum Mutat 2019 07 28;40(7):879-885. Epub 2019 Mar 28.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://dx.doi.org/10.1002/humu.23743DOI Listing
July 2019

Losartan protects against myocardial ischemia and reperfusion injury vascular integrity preservation.

FASEB J 2019 Jul 16;33(7):8555-8564. Epub 2019 Apr 16.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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https://www.fasebj.org/doi/10.1096/fj.201900060R
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http://dx.doi.org/10.1096/fj.201900060RDOI Listing
July 2019

ADAMTS16 Activates Latent TGF-beta, Accentuating Fibrosis and Dysfunction of the Pressure-overloaded Heart.

Cardiovasc Res 2019 Jul 11. Epub 2019 Jul 11.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China.

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http://dx.doi.org/10.1093/cvr/cvz187DOI Listing
July 2019

SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension.

Pulm Pharmacol Ther 2019 04 28;55:38-49. Epub 2019 Jan 28.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA; Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, OH, 44195, USA; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814199PMC
April 2019

BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis.

Blood 2019 02 27;133(8):805-815. Epub 2018 Nov 27.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

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http://dx.doi.org/10.1182/blood-2018-09-876599DOI Listing
February 2019

Analysis of causal effect of APOA5 variants on premature coronary artery disease.

Ann Hum Genet 2018 11 19;82(6):437-447. Epub 2018 Jul 19.

Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1111/ahg.12273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188800PMC
November 2018

phlda3 overexpression impairs specification of hemangioblasts and vascular development.

FEBS J 2018 11 20;285(21):4071-4081. Epub 2018 Sep 20.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China.

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http://doi.wiley.com/10.1111/febs.14653
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http://dx.doi.org/10.1111/febs.14653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218282PMC
November 2018

Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na1.5.

Biochim Biophys Acta Mol Basis Dis 2018 11 6;1864(11):3672-3684. Epub 2018 Sep 6.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, PR China; Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168416PMC
November 2018

A novel mutation cosegregates with congenital contractural arachnodactyly in a five-generation Chinese family.

Clin Case Rep 2018 Aug 3;6(8):1612-1617. Epub 2018 Jul 3.

Department of Clinical Laboratory Liyuan Hospital Tongji Medical Collage Huazhong University of Science and Technology Wuhan China.

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http://dx.doi.org/10.1002/ccr3.1693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099051PMC
August 2018

Identification of a mutation in CNNM4 by whole exome sequencing in an Amish family and functional link between CNNM4 and IQCB1.

Mol Genet Genomics 2018 Jun 10;293(3):699-710. Epub 2018 Jan 10.

Center for Genetic Eye Diseases, Cleveland Clinic Cole Eye Institute, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s00438-018-1417-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949075PMC
June 2018

Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Jun 28;27(6):1683-1691. Epub 2018 Feb 28.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China; Center for Cardiovascular Genetics, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815228PMC
June 2018

Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease.

Mol Genet Genomics 2018 Feb 11;293(1):119-128. Epub 2017 Sep 11.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

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http://link.springer.com/10.1007/s00438-017-1365-6
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http://dx.doi.org/10.1007/s00438-017-1365-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794607PMC
February 2018

Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation.

Sci Rep 2018 02 19;8(1):3297. Epub 2018 Feb 19.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://www.nature.com/articles/s41598-018-21611-7
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http://dx.doi.org/10.1038/s41598-018-21611-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818533PMC
February 2018

Lack of association between the variant rs9943582 with ischemic stroke in the Chinese Han GeneID population.

Oncotarget 2017 Dec 21;8(64):107678-107684. Epub 2017 Nov 21.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Human Genome Research Center, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://www.oncotarget.com/fulltext/22588
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http://dx.doi.org/10.18632/oncotarget.22588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746099PMC
December 2017

NINJ2- A novel regulator of endothelial inflammation and activation.

Cell Signal 2017 07 18;35:231-241. Epub 2017 Apr 18.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Human Genome Research Center, Huazhong University of Science and Technology, Wuhan 430074, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.04.011DOI Listing
July 2017

Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease.

Sci Rep 2017 07 14;7(1):5472. Epub 2017 Jul 14.

Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1038/s41598-017-05381-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511258PMC
July 2017

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.

Nat Commun 2017 07 25;8(1):133. Epub 2017 Jul 25.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430074, China.

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http://www.nature.com/articles/s41467-017-00171-w
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http://dx.doi.org/10.1038/s41467-017-00171-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527107PMC
July 2017

Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome.

Circ Res 2017 May 27;120(11):1754-1767. Epub 2017 Mar 27.

From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310324DOI Listing
May 2017

Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease.

Sci Rep 2017 02 9;7:42175. Epub 2017 Feb 9.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, P. R. China.

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http://dx.doi.org/10.1038/srep42175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299598PMC
February 2017

Loss of heterozygosity detected at three short tandem repeat locus commonly used for human DNA identification in a case of paternity testing.

Leg Med (Tokyo) 2017 Jan 5;24:7-11. Epub 2016 Nov 5.

College of Life Science and Technology and Center for Human Genome Research, Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.legalmed.2016.11.001DOI Listing
January 2017

Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.

Sci Rep 2016 10 4;6:34034. Epub 2016 Oct 4.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China.

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http://dx.doi.org/10.1038/srep34034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048429PMC
October 2016

Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation.

Physiol Genomics 2016 08 27;48(8):554-64. Epub 2016 May 27.

The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Department of Molecular Cardiology, Lerner Research Institute, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio; and Department of Molecular Medicine, Department of Genetics and Genome Science, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1152/physiolgenomics.00028.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005456PMC
August 2016

αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5.

J Biol Chem 2016 May 9;291(21):11030-41. Epub 2016 Mar 9.

From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, 1037 Luoyu Road, Huazhong University of Science and Technology, Wuhan 430074, China, the Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195,

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http://dx.doi.org/10.1074/jbc.M115.695080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900253PMC
May 2016

Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population.

Sci Rep 2016 05 12;6:25782. Epub 2016 May 12.

Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1038/srep25782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865940PMC
May 2016

Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.

PLoS One 2015 19;10(5):e0125926. Epub 2015 May 19.

Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438007PMC
April 2016

Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction.

Atherosclerosis 2016 Mar 8;246:148-156. Epub 2016 Jan 8.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764411PMC
March 2016

Identification of rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population.

Mol Genet Genomics 2016 Feb 14;291(1):79-92. Epub 2015 Jul 14.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Center for Human Genome Research and Cardio-X Institute, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

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http://dx.doi.org/10.1007/s00438-015-1090-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713376PMC
February 2016

Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm.

Sci Rep 2016 Feb 23;6:21538. Epub 2016 Feb 23.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1038/srep21538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763225PMC
February 2016

Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p.

Biochim Biophys Acta 2015 Oct 21;1852(10 Pt A):2024-34. Epub 2015 Jul 21.

Department of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757900PMC
October 2015

Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families.

PLoS One 2014 8;9(12):e113935. Epub 2014 Dec 8.

Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Ave., Cleveland, Ohio, 44195, United States of America; Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, Ohio, 44195, United States of America; Center for Sleep Medicine, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, Ohio, United States of America; Department of Genetics and Genome Sciences, Case Western Reserve University, 9500 Euclid Ave., Cleveland, Ohio, 44195, United States of America; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113935PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259362PMC
August 2015

Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation.

PLoS Genet 2015 Aug 12;11(8):e1005393. Epub 2015 Aug 12.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Center, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China; Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Molecular Medicine, Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534423PMC
August 2015

Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population.

J Am Heart Assoc 2015 May 7;4(5). Epub 2015 May 7.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China (S.C., C.W., X.W., C.X., M.W., P.W., X.T., Q.K.W.) Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH (Q.K.W.) Department of Molecular Medicine, Department of Genetics and Genome Sciences, CCLCM, Case Western Reserve University, Cleveland, OH (Q.K.W.).

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http://dx.doi.org/10.1161/JAHA.115.001980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599427PMC
May 2015

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

Hum Mol Genet 2015 Mar 26;24(6):1791-800. Epub 2014 Nov 26.

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

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http://hmg.oxfordjournals.org/content/24/6/1791.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu583
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http://dx.doi.org/10.1093/hmg/ddu583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351379PMC
March 2015

A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene.

Circ Cardiovasc Genet 2014 Aug 27;7(4):514-20. Epub 2014 May 27.

From the Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, OH (G.-Q.S., L.L., S.R., S.A., Q.C., Q.K.W.); Department of Medicine, University of Verona, Verona, Italy (D.G., O.O., N.M.); Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea (J.E.P.); The Scripps Research Institute, Scripps Clinic, La Jolla, CA (E.J.T.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China (Q.K.W.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140990PMC
August 2014

BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3.

Hum Genet 2014 May 5;133(5):499-508. Epub 2013 Nov 5.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1007/s00439-013-1389-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988217PMC
May 2014

Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.

Biochim Biophys Acta 2014 May 23;1842(5):712-25. Epub 2014 Jan 23.

The Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Genetics and Developmental Biology, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, PR China; Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.01.007DOI Listing
May 2014

MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development.

Int J Biochem Cell Biol 2014 Apr 18;49:53-63. Epub 2014 Jan 18.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, PR China; Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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April 2014

Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke.

Stroke 2014 Feb 2;45(2):383-8. Epub 2014 Jan 2.

From the Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute (Y.B., G.J., Yingchao Zhou, M.Z., Yuanyuan Zhao, S.L., F.W., Q. Lu, Y.H., Q.Y., T.K., H.L., X.R., C.X., X.T., Q.K.W.), and College of Life Science and Technology and Center for Human Genome Research, Institute of Cardiology (S.N., X.C., Y. Liao), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Cardiology, Jining Medical College Affiliated Hospital, Jining, China (Q. Li); Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China (Y. Li); Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China (Y.X., Y. Liu, J.L., Y.Y.); Department of Cardiology, Suizhou Central Hospital, Suizhou, China (J.Q.); Department of Cardiology, Xiangyang Central Hospital, Xiangyang, China (B.L.); Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China (G.W.); Department of Cardiology, Wuhan No. 1 Hospital, Wuhan, China (Y.W.); Research Institute of the National Population and Family Planning Commission, Beijing, China (B.W., X.M.); and Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, OH (Q.K.W.).

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February 2014

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.

Blood 2014 Jan 25;123(4):501-8. Epub 2013 Nov 25.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Genetics and Developmental Biology, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, People's Republic of China; and.

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January 2014

Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease.

Atherosclerosis 2013 Nov 12;231(1):136-40. Epub 2013 Sep 12.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.

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November 2013

The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population.

Am J Hum Genet 2013 Oct 26;93(4):652-60. Epub 2013 Sep 26.

Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan 430074, China.

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October 2013

Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of slc4a10.

PLoS One 2013 7;8(2):e55974. Epub 2013 Feb 7.

Department of Biophysics and Molecular Physiology, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science & Technology School of Life Science & Technology, Wuhan, Hubei, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567025PMC
August 2013

MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.

Circ Arrhythm Electrophysiol 2013 Apr 18;6(2):392-401. Epub 2013 Feb 18.

Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633223PMC
April 2013

Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI.

Ann Hum Genet 2012 May 8;76(3):193-9. Epub 2012 Mar 8.

Center for Cardiovascular Genetics, Cleveland Clinic, OH, USA.

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May 2012

Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population.

PLoS One 2011 14;6(11):e27481. Epub 2011 Nov 14.

Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215720PMC
March 2012

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.

Nat Genet 2012 Feb 12;44(3):254-6. Epub 2012 Feb 12.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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February 2012

A novel SCN1A missense mutation causes generalized epilepsy with febrile seizures plus in a Chinese family.

Neurosci Lett 2011 Sep 6;503(1):27-30. Epub 2011 Aug 6.

Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.

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September 2011

No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.

Atherosclerosis 2011 Jun 3;216(2):381-2. Epub 2011 Mar 3.

The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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June 2011

Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.

Hum Genet 2011 Mar 25;129(3):239-46. Epub 2010 Nov 25.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, China.

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March 2011

A de novo mutation in NKX2.5 associated with atrial septal defects, ventricular noncompaction, syncope and sudden death.

Clin Chim Acta 2011 Jan 4;412(1-2):170-5. Epub 2010 Oct 4.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998397PMC
January 2011

Identification of compound heterozygous mutations in GNPTG in three siblings of a Chinese family with mucolipidosis type III gamma.

Mol Genet Metab 2011 Jan 27;102(1):107-9. Epub 2010 Sep 27.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

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January 2011

Identification of a novel genetic locus on chromosome 8p21.1-q11.23 for idiopathic basal ganglia calcification.

Am J Med Genet B Neuropsychiatr Genet 2010 Oct;153B(7):1305-10

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.

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October 2010

Minor allele C of chromosome 1p32 single nucleotide polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han population.

Stroke 2010 Aug 24;41(8):1587-92. Epub 2010 Jun 24.

Key Laboratory of Molecular Biophysics of Ministry of Education, Integrated Traditional Chinese and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China.

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August 2010

Identification of a novel homozygous nonsense mutation in EYS in a Chinese family with autosomal recessive retinitis pigmentosa.

BMC Med Genet 2010 Aug 10;11:121. Epub 2010 Aug 10.

Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.

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August 2010

Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population.

Biochem Biophys Res Commun 2010 Jul 15;398(1):98-104. Epub 2010 Jun 15.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132081PMC
July 2010

Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype.

J Huazhong Univ Sci Technolog Med Sci 2010 Feb 14;30(1):103-7. Epub 2010 Feb 14.

Department of Pediatrics, Huazhong University of Science and Technology, Wuhan, 430022, China.

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February 2010

Familial aggregation analysis of gene expressions.

BMC Proc 2007 18;1 Suppl 1:S49. Epub 2007 Dec 18.

Departments of Molecular Cardiology and Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1186/1753-6561-1-s1-s49DOI Listing
December 2009

Identification of a novel splicing mutation in the growth hormone (GH)-releasing hormone receptor gene in a Chinese family with pituitary dwarfism.

Mol Cell Endocrinol 2009 Dec 4;313(1-2):50-6. Epub 2009 Sep 4.

Key Laboratory of Molecular Biophysics of Ministry of Education, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.

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December 2009

Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration.

Biochem Biophys Res Commun 2009 Oct 8;388(2):383-8. Epub 2009 Aug 8.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China.

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October 2009

A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2-q26.33.

Hum Genet 2008 Nov 2;124(4):423-9. Epub 2008 Oct 2.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 430074, Wuhan, China.

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November 2008

Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations.

BMC Med Genet 2008 Sep 23;9:87. Epub 2008 Sep 23.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570672PMC
September 2008

Identification of a genetic locus for ichthyosis vulgaris on chromosome 10q22.3-q24.2.

J Invest Dermatol 2008 Jun 13;128(6):1418-22. Epub 2007 Dec 13.

Key Laboratory of Molecular Biophysics of Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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June 2008

T14484C and T14502C in the mitochondrial ND6 gene are associated with Leber's hereditary optic neuropathy in a Chinese family.

Mitochondrion 2008 Jun 6;8(3):205-10. Epub 2008 Mar 6.

Key Laboratory of Molecular Biophysics of Ministry of Education and Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, 9500 Euclid Avenue, Wuhan 430074, China.

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http://dx.doi.org/10.1016/j.mito.2008.02.003DOI Listing
June 2008

Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1.

Hum Genet 2008 Jun 29;123(5):507-13. Epub 2008 Apr 29.

Key Laboratory of Molecular Biophysics of Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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June 2008

Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells.

Biochim Biophys Acta 2008 May 20;1782(5):303-9. Epub 2008 Feb 20.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P.R. China.

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May 2008

Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population.

J Hum Genet 2008 8;53(2):144-50. Epub 2007 Dec 8.

Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA.

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April 2008

Identification and functional characterization of a novel splicing mutation in RP gene PRPF31.

Biochem Biophys Res Commun 2008 Mar 3;367(2):420-6. Epub 2008 Jan 3.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, PR China.

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http://dx.doi.org/10.1016/j.bbrc.2007.12.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712755PMC
March 2008

Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease.

Arterioscler Thromb Vasc Biol 2008 Feb 29;28(2):360-5. Epub 2007 Nov 29.

Department of Molecular Cardiology, Lerner Research Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.157248DOI Listing
February 2008

A novel DSPP mutation is associated with type II dentinogenesis imperfecta in a Chinese family.

BMC Med Genet 2007 Aug 8;8:52. Epub 2007 Aug 8.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

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http://dx.doi.org/10.1186/1471-2350-8-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995191PMC
August 2007

A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis pigmentosa in a Chinese family.

Mol Vis 2007 Aug 30;13:1548-54. Epub 2007 Aug 30.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan Hubei, China.

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August 2007

Identification of a novel GPR143 mutation in a large Chinese family with congenital nystagmus as the most prominent and consistent manifestation.

J Hum Genet 2007 22;52(6):565-70. Epub 2007 May 22.

Center for Human Genome Research and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, and Development of Proof-Testing, Renmin Hospital of Tanghe, Henan, People's Republic of China.

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July 2007

Induction of high STAT1 expression in transgenic mice with LQTS and heart failure.

Biochem Biophys Res Commun 2007 Jun 26;358(2):449-54. Epub 2007 Apr 26.

Center for Cardiovascular Genetics and Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505674PMC
June 2007

Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.

Biochem Biophys Res Commun 2007 Apr 7;355(2):444-50. Epub 2007 Feb 7.

Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute/NE40, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885482PMC
April 2007

A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family with hypohidrotic ectodermal dysplasia.

J Hum Genet 2006 26;51(12):1133-7. Epub 2006 Oct 26.

Center for Human Genome Research, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.

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February 2007

Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes.

Biochem Biophys Res Commun 2007 Jan 14;352(2):378-83. Epub 2006 Nov 14.

Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773013PMC
January 2007

Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.

Biochem Biophys Res Commun 2007 Jan 1;352(4):879-83. Epub 2006 Dec 1.

Department of Molecular Cardiology, Lerner Research Institute and Center for Cardiovascular Genetics, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699586PMC
January 2007

Fluorescence in situ hybridization in cardiovascular disease.

Methods Mol Med 2006 ;128:11-21

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Construction of somatic cell hybrid lines: fusion of mouse thymidine kinase-deficient 3T3 fibroblasts and human lymphoblastoid cells.

Methods Mol Med 2006 ;128:33-40

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

LINKAGE programs: linkage analysis for monogenic cardiovascular diseases.

Methods Mol Med 2006 ;128:41-60

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

SAGE programs: model-free linkage analysis for complex cardiovascular phenotypes.

Methods Mol Med 2006 ;128:61-89

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

High-throughput single-nucleotide polymorphisms genotyping: TaqMan assay and pyrosequencing assay.

Methods Mol Med 2006 ;128:209-24

Center for Molecular Genetics, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Microarray analysis of cardiovascular diseases.

Methods Mol Med 2006 ;129:1-13

Center for Molecular Genetics, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Proteomics with two-dimensional gel electrophoresis and mass spectrometry analysis in cardiovascular research.

Methods Mol Med 2006 ;129:15-26

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Generation of transgenic mice for cardiovascular research.

Methods Mol Med 2006 ;129:69-81

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Animal models for cardiac arrhythmias.

Methods Mol Med 2006 ;129:127-48

Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA.

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December 2006

Genetic susceptibility to myocardial infarction and coronary artery disease.

Hum Mol Genet 2006 Oct;15 Spec No 2:R117-23

Department of Genetics, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, BRB 724, 10900 Euclid Avenue, Cleveland, OH 44106-4955, USA.

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October 2006