Publications by authors named "Qin Lin"

284 Publications

Dependence of Xpert MTB/RIF Accuracy for Detecting Rifampin Resistance in Bronchoalveolar Lavage Fluid on Bacterial Load: A Retrospective Study in Beijing, China.

Infect Drug Resist 2021 28;14:2429-2435. Epub 2021 Jun 28.

Department of Bacteriology and Immunology, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, 101149, People's Republic of China.

Introduction: We assessed the effect of (MTB) bacterial load on Xpert MTB/RIF accuracy for detection of rifampicin (RIF)-resistant MTB in bronchoalveolar lavage fluid (BALF) specimens obtained at a national tuberculosis (TB) specialized hospital in Beijing, China.

Methods: A retrospective study was conducted at Beijing Chest Hospital. Patients with symptoms suggestive of pulmonary TB who provided BALF specimens for routine MTB detection between June 2019 and July 2020 were enrolled in the study. Chi-square test and Student's -test were used to compare results across groups stratified according to BALF bacterial load.

Results: In total, 1125 patients with positive Xpert results who were enrolled in final analysis, 263 provided BALF specimens that tested positive for RIF-resistant MTB via Xpert MTB/RIF. The RIF-resistance rate of specimens with very low MTB bacterial load was 30.9%, a resistance rate significantly greater than rates obtained for groups with high (25.0%), medium (17.3%) and low (19.2%) MTB loads (<0.01). Notably, false-positive results obtained for the very low bacterial load group led to markedly reduced positive predictive value of Xpert MTB/RIF to provide correct RIF-resistance predictions for that group (67.1%, 95% CI: 56.1%-78.1%5) relative to the predictive value obtained for all other groups combined (about 90%, <0.05). Sanger sequencing data obtained for 20 (32.8%) MTB isolates deemed RIF-resistant via Xpert (Probe E) lacked RRDR mutations. Meanwhile, of another group of 23 isolates deemed RIF-susceptible via DST but RIF-resistant via Xpert MTB/RIF, 20 isolate sequences (87.0%) lacked RRDR mutations, while sequences of the remaining 3 isolates harbored single RRDR mutations predicted to cause amino acid substitutions.

Conclusion: Xpert MTB/RIF assay performed alarmingly poorly when used to detect RIF-resistant MTB in BALF specimens with very low bacterial loads. A high rate of Xpert probe E hybridization failure was the main driver of false-positive RIF-resistant results.
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http://dx.doi.org/10.2147/IDR.S307488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254186PMC
June 2021

Serratus anterior plane block reduces the prevalence of chronic postsurgical pain after modified radical mastectomy: A randomized controlled trial.

J Clin Anesth 2021 Jun 24;74:110410. Epub 2021 Jun 24.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Study Objective: To determine whether ultrasound-guided serratus anterior plane block (SAPB) is associated with decreased prevalence of chronic postsurgical pain (CPSP) after modified radical mastectomy.

Design: Randomized, double-blind, placebo-controlled study.

Setting: University hospital.

Patients: We enrolled 198 patients aged 18-65 years with American Society of Anesthesiologists physical status I to II, undergoing unilateral modified radical mastectomy.

Interventions: Patients were randomly allocated to receive SAPB with 30 ml of 0.5% ropivacaine (SAPB group) or 0.9% normal saline (Control group).

Measurements: The primary outcome was the prevalence of CPSP three months after surgery. Secondary outcomes were area under the curve of the numeric rating scale pain scores over 24 h, postoperative 24-h morphine consumption, quality of recovery, length of post-anesthesia care unit stay, postoperative nausea and vomiting, dizziness, SAPB-related adverse events, the prevalence of CPSP at six months, and pain-related function at three and six months.

Main Results: Preoperative SAPB with 0.5% ropivacaine reduced the prevalence of CPSP at three postoperative months from 46/89 (51.7%) to 22/90 (25.6%), relative risk (95% confidence interval): 0.47 (0.31-0.72), P < 0.001. The prevalence of CPSP was reduced at six months from 37/89 (41.6%) to 17/90 (18.9%), relative risk (95% confidence interval): 0.72 (0.58-0.88), P = 0.001. Moreover, SAPB decreased the area under the curve of the numeric rating scale pain scores over 24 h, shortened the length of post-anesthesia care unit stay, reduced postoperative 24-h morphine consumption and the occurrence of postoperative nausea and vomiting, and improved quality of recovery and patient satisfaction, with P < 0.05 for all. No SAPB-related complications occurred.

Conclusions: Preoperative SAPB with ropivacaine improved acute postoperative analgesia and quality of recovery and decreased the prevalence of CPSP at three and six months after modified radical mastectomy.
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http://dx.doi.org/10.1016/j.jclinane.2021.110410DOI Listing
June 2021

The association between family impact and health-related quality of life of children with idiopathic central precocious puberty in Chongqing, China.

Health Qual Life Outcomes 2021 Jun 26;19(1):171. Epub 2021 Jun 26.

Department of General Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Jinyu Avenue No. 20, Yubei, Chongqing, 400010, China.

Background: Idiopathic central precocious puberty (ICPP) reduces patient health-related quality of life (HRQoL). The impacts of disease and treatment on families are also an important concern. This study aimed to assess the association between family impact and HRQoL of children with ICPP.

Methods: We conducted a case-control study in Chongqing, China. A case group of 134 children with ICPP aged 5-12 years and their caregivers was recruited from a children's hospital in Chongqing. A total of 210 gender- and age-matched subjects from two primary schools were selected as controls. PedsQL4.0 Generic Core Scales (GCS) and PedsQL™ Family Impact Module (FIM) were used in this study.

Results: Children with ICPP scored lower than controls in all HRQoL domains except physical functioning. In particular, the two groups were significantly different in emotional functioning scores (d = 0.414, P < 0.001). Compared with controls, ICPP families had lower scores in all dimensions of the FIM scale (d = 0.288-1.030, all P < 0.05). Factors associated with HRQoL of ICPP patients included: age of patients, type of medical treatment, employment status of caregivers, educational level of caregivers, parent HRQoL and family functioning (all P < 0.05).

Conclusions: Children with ICPP demonstrated lower quality of life and greater family impact compared to healthy controls. In addition, less impact of disease on parent HRQoL and family functioning was associated with better HRQoL of ICPP patients, patients aged older, treated with drug combination, cared by employed or well-educated caregivers reported better HRQoL. Health care professionals should pay more attention to younger patients treated with GnRHa alone, and provide targeted interventions for caregivers depending on their demographic background to reduce family impact and thereby improve patient HRQoL.
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http://dx.doi.org/10.1186/s12955-021-01805-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236152PMC
June 2021

Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial.

Lancet Oncol 2021 Jun 23. Epub 2021 Jun 23.

Jiangsu Hengrui Pharmaceuticals, Shanghai, China.

Background: The addition of camrelizumab to gemcitabine and cisplatin showed promising activity as first-line therapy in patients with recurrent or metastatic nasopharyngeal carcinoma in a phase 1 trial. We therefore compared camrelizumab plus gemcitabine and cisplatin with placebo plus gemcitabine and cisplatin in a randomised phase 3 trial.

Methods: In this randomised, double-blind, phase 3 trial done at 28 hospitals in China, patients were eligible if they were aged 18-75 years, had an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and had previously untreated recurrent or metastatic nasopharyngeal carcinoma. Patients were randomly assigned (1:1; using an interactive web-response system with a block size of four) to receive either camrelizumab (200 mg on day 1) or matching placebo intravenously, plus gemcitabine and cisplatin (gemcitabine 1000 mg/m on days 1 and 8; cisplatin 80 mg/m on day 1) intravenously every 3 weeks for four to six cycles, followed by maintenance therapy with camrelizumab or placebo, until radiographic progression, unacceptable toxicity, start of new anticancer treatment, investigator decision, or withdrawal of consent. Stratification factors used in randomisation were liver metastases, previous radical concurrent chemoradiotherapy, and ECOG performance status. The allocation sequence was generated by an independent randomisation group. The primary endpoint was progression-free survival per independent review committee. The significance threshold for independent review committee-assessed progression-free survival was p=0·0086 (one-sided) at the interim analysis. Efficacy and safety analyses included all patients who received at least one dose of study drug. This trial is registered with ClinicalTrials.gov, NCT03707509, and is closed for enrolment but is ongoing.

Findings: Between Nov 13, 2018, and Nov 29, 2019, 343 patients were screened and 263 were eligible and were randomly assigned to the camrelizumab group (n=134) or placebo group (n=129). At the prespecified interim analysis (June 15, 2020), independent review committee-assessed progression-free survival was significantly longer in the camrelizumab group (median 9·7 months [95% CI 8·3-11·4]) than in the placebo group (median 6·9 months [5·9-7·3]; hazard ratio 0·54 [95% CI 0·39-0·76]; one-sided p=0·0002). As of Dec 31, 2020, the most common grade 3 or worse adverse events of any cause were decreased white blood cell count (89 [66%] of 134 patients in the camrelizumab group vs 90 [70%] of 129 patients in the placebo group), decreased neutrophil count (86 [64%] vs 85 [66%]), anaemia (53 [40%] vs 57 [44%]), and decreased platelet count (53 [40%] vs 52 [40%]). Serious adverse events were reported in 59 (44%) of 134 patients in the camrelizumab group and 48 (37%) of 129 patients in the placebo group. Treatment-related deaths occurred in five (4%) patients in the camrelizumab group (two unknown cause of death, one multiple organ dysfunction syndrome, one pharyngeal haemorrhage, and one arrhythmia) and one (<1%) patient in the placebo group (unknown cause of death).

Interpretation: Our findings suggest that camrelizumab plus gemcitabine and cisplatin could be a new standard of care for patients with recurrent or metastatic nasopharyngeal carcinoma in the first-line setting. Longer follow-up is needed to confirm this conclusion.

Funding: Jiangsu Hengrui Pharmaceuticals (formerly Jiangsu Hengrui Medicine).

Translation: For the Chinese translation of the abstract see Supplementary Materials section.
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http://dx.doi.org/10.1016/S1470-2045(21)00302-8DOI Listing
June 2021

Impacts of Reduced Nitrate Supply on Nitrogen Metabolism, Photosynthetic Light-Use Efficiency, and Nutritional Values of Edible .

Authors:
Jie He Lin Qin

Front Plant Sci 2021 4;12:686910. Epub 2021 Jun 4.

National Institute of Education, Nanyang Technological University, Singapore, Singapore.

(common ice plant), as a nutritious ready-to-eat salad in Singapore, has become popular in recent years. However, basic data about the impacts of NO supply on its NO accumulation and nutritional quality are lacking. In this study, all plants were first grown indoor hydroponically in 10% artificial seawater (ASW) with modified full-strength Netherlands Standard Composition nutrient solution for 11 days, before transferring them to different reduced NO solutions. All plants grew well and healthy after 7 days of treatment. However, plants grown with 3/4 N and 1/2 N were bigger with higher shoot and root fresh weight (FW), greater leaf number, and total leaf area (TLA) than those grown with full nitrogen (N), 1/4 N, and 0 N. grown with full N, 3/4 N, and 1/4 N had similar specific leaf area (SLA), while 0 N plants had significantly lower SLA. All plants had similar leaf succulence (LS). However, leaf water content (LWC) was lower, while leaf dry matter accumulation (LDMC) was higher in 0 N plants after 7 days of treatment. Compared with plants grown with full N, shoot NO concentrations in 3/4 N, 1/2 N, and 1/4 N plants were constant or slightly increased during the treatments. For 0 N plants, shoot NO concentration decreased significantly during the treatment compared with other plants. Shoot NO accumulation was associated with nitrate reductase activity (NRA). For instance, after 7 days of treatment, shoot NO concentration and NRA on a FW basis in 0 N plants were, respectively, 45 and 31% of full N plants. After transferring full N to 0 N for 7 days, all had higher chlorophyll (Chl) content coupled with higher electron transport rate (ETR) and higher effective quantum yield of PSII, while full N plants had higher non-photochemical quenching (NPQ). The 0N plants had much higher concentrations of proline, total soluble sugar (TSS), and total ascorbic acid (ASC) than other plants. In conclusion, totally withdrawing NO from the growth media prior to harvest could be one of the strategies to reduce shoot NO concentration. Reduced NO supply further enhanced nutritional values as concentrations of proline, TSS, and ASC were enhanced markedly in plants after transferring them from full N to 0 N.
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http://dx.doi.org/10.3389/fpls.2021.686910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213338PMC
June 2021

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.

Lancet 2021 07 7;398(10297):303-313. Epub 2021 Jun 7.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

Background: Patients with locoregionally advanced nasopharyngeal carcinoma have a high risk of disease relapse, despite a high proportion of patients attaining complete clinical remission after receiving standard-of-care treatment (ie, definitive concurrent chemoradiotherapy with or without induction chemotherapy). Additional adjuvant therapies are needed to further reduce the risk of recurrence and death. However, the benefit of adjuvant chemotherapy for nasopharyngeal carcinoma remains controversial, highlighting the need for more effective adjuvant treatment options.

Methods: This multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial was done at 14 hospitals in China. Patients (aged 18-65 years) with histologically confirmed, high-risk locoregionally advanced nasopharyngeal carcinoma (stage III-IVA, excluding T3-4N0 and T3N1 disease), no locoregional disease or distant metastasis after definitive chemoradiotherapy, an Eastern Cooperative Oncology Group performance status of 0 or 1, sufficient haematological, renal, and hepatic function, and who had received their final radiotherapy dose 12-16 weeks before randomisation, were randomly assigned (1:1) to receive either oral metronomic capecitabine (650 mg/m body surface area twice daily for 1 year; metronomic capecitabine group) or observation (standard therapy group). Randomisation was done with a computer-generated sequence (block size of four), stratified by trial centre and receipt of induction chemotherapy (yes or no). The primary endpoint was failure-free survival, defined as the time from randomisation to disease recurrence (distant metastasis or locoregional recurrence) or death due to any cause, in the intention-to-treat population. Safety was assessed in all patients who received at least one dose of capecitabine or who had commenced observation. This trial is registered with ClinicalTrials.gov, NCT02958111.

Findings: Between Jan 25, 2017, and Oct 25, 2018, 675 patients were screened, of whom 406 were enrolled and randomly assigned to the metronomic capecitabine group (n=204) or to the standard therapy group (n=202). After a median follow-up of 38 months (IQR 33-42), there were 29 (14%) events of recurrence or death in the metronomic capecitabine group and 53 (26%) events of recurrence or death in the standard therapy group. Failure-free survival at 3 years was significantly higher in the metronomic capecitabine group (85·3% [95% CI 80·4-90·6]) than in the standard therapy group (75·7% [69·9-81·9]), with a stratified hazard ratio of 0·50 (95% CI 0·32-0·79; p=0·0023). Grade 3 adverse events were reported in 35 (17%) of 201 patients in the metronomic capecitabine group and in 11 (6%) of 200 patients in the standard therapy group; hand-foot syndrome was the most common adverse event related to capecitabine (18 [9%] patients had grade 3 hand-foot syndrome). One (<1%) patient in the metronomic capecitabine group had grade 4 neutropenia. No treatment-related deaths were reported in either group.

Interpretation: The addition of metronomic adjuvant capecitabine to chemoradiotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a manageable safety profile. These results support a potential role for metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.

Funding: The National Natural Science Foundation of China, the Key-Area Research and Development Program of Guangdong Province, the Natural Science Foundation of Guangdong Province, the Innovation Team Development Plan of the Ministry of Education, and the Overseas Expertise Introduction Project for Discipline Innovation.

Translation: For the Chinese translation of the abstract see Supplementary Materials section.
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http://dx.doi.org/10.1016/S0140-6736(21)01123-5DOI Listing
July 2021

Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance.

Biomaterials 2021 May 21;275:120891. Epub 2021 May 21.

Department of Orthopedics, Zhuhai Hospital, Jinan University, Zhuhai People's Hospital, 79 Kangning Road, Zhuhai, 519000, China. Electronic address:

Insufficient drug accumulation and chemoresistance remain two major challenges in cancer chemotherapy. Herein, we designed a furin-responsive aggregated nanoplatform loaded with doxorubicin (DOX) and hydroxychloroquine (HCQ) (AuNPs-D&H-R&C) to combine chemotherapy, autophagy inhibition and macrophage polarization. AuNPs-D&H-R&C could passively target breast tumor via enhanced permeability and retention (EPR) effect after systemic administration and further aggregate together triggered by furin overexpressed in breast cancer. The in situ aggregations hindered the back-flow of NPs to the bloodstream and exocytosis of tumor cells, leading to enhanced drug accumulation within tumors. Moreover, upon exposure to acidic pH in the endosomes/lysosomes, HCQ was efficiently released and it inhibited autophagy and thus restored the sensitivity of tumor cell to DOX. Meanwhile, autophagy inhibition could reprogram tumor-promoting M2-like TAMs to anti-tumor M1 phenotype, exerting a synergistic effect in overcoming chemoresistance. In vitro studies demonstrated the superiority of furin-triggered aggregated AuNPs delivery system in enhancing drug accumulation in breast tumor, compared with PEGlyated AuNPs. The co-delivery of DOX and HCQ showed much improved chemotherapeutic efficiency to chemoresistant MCF-7/ADR breast tumor, in large part due to macrophage polarization. In conclusion, we developed a stimulus-responsive delivery system and proposed a potential combination strategy to overcome chemoresistance in cancer chemotherapy.
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http://dx.doi.org/10.1016/j.biomaterials.2021.120891DOI Listing
May 2021

Safety and Effectiveness of Modified Expansive Open-door Laminoplasty Using a Ultrasonic Bone Scalpel Compared With a High-speed Drill.

Clin Spine Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China.

Study Design: This was a retrospective study.

Objective: Our study aimed to compare the effectiveness and safety of ultrasonic bone scalpel (UBS) and high-speed drill (HSD) in modified expansive open-door laminoplasty.

Summary Of Background Data: The traditional methods of decompression mostly use HSD and laminectomy forceps to lift the lamina. As a new type of bone cutting instrument, UBS has the advantages of good tissue selectivity, bone cutting accuracy, good hemostasis, cold cutting, and easy operation, leading to its popular use in surgery.

Materials And Methods: Forty-two patients who underwent modified expansive open-door laminoplasty for multilevel cervical spondylotic myelopathy were included in this study. They were divided into HSD and UBS groups (n=18 and 24, respectively). Data on demographics, operation duration, blood loss, postoperative drainage, extubation time, length of stay, cost of hospitalization, and complications were collected and compared. Modified Japanese Orthopedic Association score, visual analog scale, Neck Disability Index, and axial symptoms were also recorded and analyzed.

Results: The blood loss in the UBS group was 255.4±217.5 mL, which was lower than that in the HSD group (490.6±389.4 mL, P=0.030). The cost of hospitalization was similar between the 2 groups. The operative time and postoperative drainage did not significantly differ (P>0.05). The modified Japanese Orthopedic Association score, visual analog scale score, and Neck Disability Index score after surgery were better than those before surgery (P<0.05), but no significant difference existed between the 2 groups in each period (P>0.05). No significant difference existed in the incidence of axial symptoms and other complications (P>0.05).

Conclusion: The application of the UBS to modified open-door laminoplasty resulted in a safe and effective decompression effect and reduced blood loss without increasing cost benefit.
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http://dx.doi.org/10.1097/BSD.0000000000001188DOI Listing
May 2021

LED spectral quality and NaCl salinity interact to affect growth, photosynthesis and phytochemical production of Mesembryanthemum crystallinum.

Funct Plant Biol 2021 May 11. Epub 2021 May 11.

The edible halophyte Mesembryanthemum crystallinum L. was grown at different NaCl salinities under different combined red and blue light-emitting diode (LED) light treatments. High salinity (500 mM NaCl) decreased biomass, leaf growth, and leaf water content. Interactions between LED ratio and salinity were detected for shoot biomass and leaf growth. All plants had Fv/Fm ratios close to 0.8 in dark-adapted leaves, suggesting that they were all healthy with similar maximal efficiency of PSII photochemistry. However, measured under the actinic light near or above the growth light, the electron transport rate (ETR) and photochemical quenching (qP) of M. crystallinum grown at 100 and 250 mM NaCl were higher than at 500 mM NaCl. Grown under red/blue LED ratios of 0.9, M. crystallinum had higher ETR and qP across all salinities indicating higher light energy utilisation. Crassulacean acid metabolism (CAM) was induced in M. crystallinum grown at 500 mM NaCl. CAM-induced leaves had much higher non-photochemical quenching (NPQ), suggesting that NPQ can be used to estimate CAM induction. M. crystallinum grown at 250 and 500 mM NaCl had higher total chlorophyll and carotenoids contents than at 100 mM NaCl. Proline, total soluble sugar, ascorbic acid, and total phenolic compounds were higher in plants at 250 and 500 mM NaCl compared with those at 100 mM NaCl. An interaction between LED ratio and salinity was detected for proline content. Findings of this study suggest that both salinity and light quality affect productivity, photosynthetic light use efficiency, and proline accumulation of M. crystallinum.
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http://dx.doi.org/10.1071/FP20375DOI Listing
May 2021

A special core-shell ZnS-CNTs/[email protected] cathode constructed to elevate electrochemical performances of lithium-sulfur batteries.

J Colloid Interface Sci 2021 Oct 17;599:416-426. Epub 2021 Apr 17.

Key Laboratory of Polar Materials and Devices, Department of Optoelectronics, East China Normal University, Shanghai 200241, China.

Lithium-sulfur batteries (LSBs) are regarded as promising candidates for next-generation electrochemical energy storage systems due to their low cost and high energy density. However, the insulative sulfur, the volume expansion and high soluble polysulfides are three roots impeding their practical applications, and consequently bring challenges of low sulfur utilization, poor cyclic stability and sluggish redox kinetics. Herein, a special core-shell ZnS-CNTs/[email protected](OH) (labeled as ZnS-CNTs/[email protected]) cathode has been designed to overcome above obstacles and elevate the electrochemical performance. The ZnS-CNTs/[email protected] cathode is synthesized via a facile step-by-step strategy, in which ZnS-decorated CNTs was used as a framework to load sulfur and followed with a ultrathin Ni(OH) (NH) layer encapsulation. The ZnS-CNT core combines merits of CNT network and polar ZnS quantum dots (QDs), accommodating the volume change, offering efficient pathways for fast electron/ion transport, and anchoring polysulfides through polar interactions. The outer Ni(OH) shell physically confines the active material and meanwhile provides plenty of catalytic sites for effective polysulfide chemisorption. Benefiting from these merits, the ZnS-CNTs/[email protected] cathode exhibits excellent cell performances in comparison with ZnS-CNTs/S and CNTs/S. Its discharge capacity at different C-rates is optimal in the three cathodes, which decreases from 1037.0 mAh g at 0.1 C to 646.1 mAh g at 2.0 C. Its cyclic capacity also manifests the slowest reduction from 861.1 to 760.1 mAh g after 150 cycles at 0.5 C, showing a high retention (88.3%) and a tiny average fading rate (0.078%). The strategy in this work provides a feasible approach to design and construct core-shell cathode materials for realizing practically usable Li-S batteries.
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http://dx.doi.org/10.1016/j.jcis.2021.04.063DOI Listing
October 2021

A deep learning approach for the fast generation of acoustic holograms.

J Acoust Soc Am 2021 Apr;149(4):2312

Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Acoustic holographic techniques are crucial in diverse applications, such as three-dimensional holographic display and particle manipulation. However, conventional methods for computer-generated acoustics holography rely heavily on iterative optimization algorithms, which are time-consuming and particularly hinder their capacity of generating a dynamic hologram in real time. Here, a deep learning approach based on U-Net is proposed to rapidly generate an acoustic hologram with optimal amplitude and phase maps. It is demonstrated that, after being trained with adequate data that are numerically synthesized by the pseudo-inverse method, the proposed deep learning approach can generate both amplitude and phase maps for new target images with an improved overall reconstruction quality. Remarkably, after the offline cost is compensated by a lower online cost for the proposed DL approach, the hologram generation speed is significantly accelerated by the proposed deep learning approach as compared with the pseudo-inverse method, especially for complicated or dynamic images. With the hierarchical feature learning capability and the fast online computational speed, the proposed deep learning approach can serve as a smart platform for rapidly generating complete maps of holograms for the sophisticated or dynamical target images, leading to the new possibility of real-time acoustic-hologram-based applications.
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http://dx.doi.org/10.1121/10.0003959DOI Listing
April 2021

The role of recombinant human brain natriuretic peptide on the cardiac output of patients with acute decompensated heart failure using Guyton venous return curve: A STROBE-compliant retrospective study.

Medicine (Baltimore) 2021 Apr;100(17):e25492

Department of Intensive Care Unit, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Abstract: rbBNP has positive cardiac effects in patients with acute decompensated heart failure, but its effects on the systemic venous circulation are not known.A single-center retrospective, self-controlled study was conducted on 14 patients undergone recombinant human brain natriuretic peptide (rhBNP) treatment between January 1, 2015 to December 31, 2018.The cardiac output (CO) significantly increased from 3.75 ± 1.14 L min-1 to 4.24 ± 0.97 L min-1 30 minutes after rbBNP infusion, and to 4.20 ± 1.19 L min-1 3 hours later. The systemic vascular resistance significantly decreased from 18.85 ± 7.66 mm Hg min L-1 to 14.62 ± 6.13 mm Hg min L-1 30 minutes. The resistance to venous return (VR) significantly decreased from 5.93 ± 4.97 mm Hg min L-1 to 4.46 ± 1.53 mmHg min L-1 3 hours later. The mean systemic filling pressure significantly decreased from 32.71 ± 20.00 mm Hg to 28.254 ± 6.09 mm Hg 3 hours later.The role of rhBNP on CO was to reduce the peripheral circulation resistance at 30 minutes after rhBNP infusion and to reduce the resistance to VR at 3 hours later.This trial is registered at ChiCTR: ID ChiCTR1900024562.
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http://dx.doi.org/10.1097/MD.0000000000025492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084054PMC
April 2021

High Salinity Reduces Plant Growth and Photosynthetic Performance but Enhances Certain Nutritional Quality of C Halophyte L. Grown Hydroponically Under LED Lighting.

Front Plant Sci 2021 22;12:651341. Epub 2021 Mar 22.

National Institute of Education, Nanyang Technological University, Singapore, Singapore.

L. (known as purslane) is one of the most nutritious leafy vegetables owing to its high content of antioxidants. In this study, all plants were grown indoors hydroponically with different NaCl salinities. Photosynthetic photo flux density (PPFD) at 200 μmol m s (12 h) was provided to all plants by LED with red:blue ratio of 2.2. Thirty days after transplanting, plants grown with100 mM NaCl had the highest productivity and the fastest leaf growth followed by those with 0, 200 and 300 mM NaCl. Grown with 300 mM NaCl, purslane had the lowest specific leaf area due to its highest leaf dry matter content and its lowest water content. All plants had similar values of leaf succulence except for those with 300 mM NaCl. Total chlorophyll and carotenoids contents were significantly higher in plants grown with 0 and 100 mM NaCl than with 200, and 300 mM NaCl. All plants had F/F ratios close to 0.8. However, electron transport rate and ΔF/F' were significantly higher in plants grown with 0 and 100 mM NaCl than with 200 and 300 mM NaCl. CAM-induced purslane with 300 mM NaCl had higher non-photochemical quenching. Maximum net photosynthetic O evolution rate and Cyt concentration were significantly lower with 300 mM NaCl compared to all other plants while all plants had similar PS II concentration. Proline concentration increased with increasing salinities. All plants had similar levels of total soluble sugars. Plants grown with 0 and 100 mM NaCl had significantly higher concentrations of NO , total reduced nitrogen, total leaf soluble protein, Rubisco protein, total ascorbic acid, and total phenolic compounds than with 200 and 300 mM NaCl. The highest concentrations of K, Ca, and Mg were found in purslane grown under 0 mM NaCl. Statistically, no significant differences in Fe concentrations were observed among all plants. However, salinity seems to increase Fe concentration. In conclusion, it is feasible to grow purslane under 100 mM NaCl as it is the most optimal condition to achieve higher productivity and better quality. However, the production of antioxidants may depend on not only salinity but also other growth conditions.
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http://dx.doi.org/10.3389/fpls.2021.651341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019967PMC
March 2021

A procedure and device for determining complex material permittivity using the free-space resonance method.

Rev Sci Instrum 2021 Mar;92(3):035104

Chengdu Enchi Microwave Technology Co., Ltd., Chengdu, China.

The essential technologies of the complex permittivity of microwave dielectric materials are systematically designed, and the complex permittivity of materials is tested nondestructively by the free-space resonance method. A testing system was built by using a mobile surveying platform, and the complex dielectric constant of the material in the X band was nondestructively tested by using the algorithm of variable physical cavity length and constant physical cavity length. Focusing on the impact of variable physical cavity length on the test results, the cavity calibration technology is proposed to reduce the influence on the complex dielectric constant test of materials. The free-space resonance method was used to test the complex permittivity of polytetrafluoroethylene, glass steel plate (fiber reinforced plastics), and corundum plate. The results show that the test results of complex permittivity obtained by the two algorithms are consistent, and the error of complex permittivity is less than 5%.
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http://dx.doi.org/10.1063/5.0035361DOI Listing
March 2021

X-ray-Activated Simultaneous Near-Infrared and Short-Wave Infrared Persistent Luminescence Imaging for Long-Term Tracking of Drug Delivery.

ACS Appl Mater Interfaces 2021 Apr 2;13(14):16166-16172. Epub 2021 Apr 2.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.

Both short-wave infrared (SWIR: 900-1700 nm) and near-infrared (NIR: 650-900 nm) luminescence possess lower optical scattering and higher signal-to-noise in deep tissues than conventional luminescence, gaining increasing attention in biomedicine. Herein, we designed mesoporous silica-coated Yb-doped magnesium germanate nanoparticles (mMGOs) with excellent two-in-one NIR and SWIR persistent luminescence after X-ray irradiation by simply regulating the valence of rare-earth ions, which also possess high cargo loading and a controlled release profile in the tumor region. The investigations and showed that mMGOs were repeatedly activated to realize rechargeable persistent luminescence imaging for tracking cargo delivery in mice. Moreover, the stimulative drug-release profile inhibited tumor growth effectively. Both of the X-ray excited two-in-one NIR and SWIR persistent luminescence imaging not only allowed for rechargeable imaging of deep tumors but also achieved long-term tracking with a remarkable tumor inhibition effect.
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http://dx.doi.org/10.1021/acsami.1c02372DOI Listing
April 2021

Clinical utility of [Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography for primary staging and recurrence detection in nasopharyngeal carcinoma.

Eur J Nucl Med Mol Imaging 2021 Apr 1. Epub 2021 Apr 1.

Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Purpose: This study aimed to explore the clinical utility of [Ga]Ga-labeled fibroblast activation protein inhibitor ([Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) relative to [F]-fluorodeoxyglucose ([F]FDG) PET/CT and magnetic resonance imaging (MRI) for primary staging and recurrence detection in nasopharyngeal carcinoma (NPC).

Methods: This retrospective analysis utilized a sub-cohort of patients from a previously acquired database. Patients with NPC who underwent [F]FDG and [Ga]Ga-FAPI PET/CT between October 2019 and November 2020 were included. The radiotracer uptake and clinical staging/restaging performances of [F]FDG and [Ga]Ga-FAPI PET/CT were compared.

Results: Forty-five participants (39 for initial assessment, 6 for recurrence detection) were included. In treatment-naïve participants, [Ga]Ga-FAPI PET/CT showed higher radiotracer uptake than [F]FDG PET/CT in primary tumors (16.18 vs. 10.11, P < 0.001), regional lymph nodes (11.42 vs. 7.37, P < 0.001), and bone and visceral metastases (6.94 vs. 3.11, P < 0.001). Compared with the [F]FDG-based TNM stage, the [Ga]Ga-FAPI-based TNM stage was upgraded in ten patients (26%), resulting in management changes in seven patients (18%). Compared with MRI, [Ga]Ga-FAPI PET/CT upgraded and underestimated the T stage in four and two patients, respectively. In post-treatment patients, [Ga]Ga-FAPI PET/CT yielded more true-positive findings than [F]FDG PET/CT in detecting local recurrence.

Conclusion: [Ga]Ga-FAPI PET/CT is a promising imaging modality for the diagnosis of primary and metastatic NPC. The exact tumor geographic imaging obtained through [Ga]Ga-FAPI PET/CT may be a supplement to MRI for T staging and radiotherapy planning.
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http://dx.doi.org/10.1007/s00259-021-05336-wDOI Listing
April 2021

Nanovaccine-Based Strategies to Overcome Challenges in the Whole Vaccination Cascade for Tumor Immunotherapy.

Small 2021 Jul 26;17(28):e2006000. Epub 2021 Mar 26.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.

Nanovaccine-based immunotherapy (NBI) has received greater attention recently for its potential to prime tumor-specific immunity and establish a long-term immune memory that prevents tumor recurrence. Despite encouraging results in the recent studies, there are still numerous challenges to be tackled for eliciting potent antitumor immunity using NBI strategies. Based on the principles that govern immune response, here it is proposed that these challenges need to be addressed at the five critical cascading events: Loading tumor-specific antigens by nanoscale drug delivery systems (L); Draining tumor antigens to lymph nodes (D); Internalization by dendritic cells (DCs) (I); Maturation of DCs by costimulatory signaling (M); and Presenting tumor-peptide-major histocompatibility complexes to T cells (P) (LDIMP cascade in short). This review provides a detailed and objective overview of emerging NBI strategies to improve the efficacy of nanovaccines in each step of the LDIMP cascade. It is concluded that the balance between each step must be optimized by delicate designing and modification of nanovaccines and by combining with complementary approaches to provide a synergistic immunity in the fight against cancer.
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http://dx.doi.org/10.1002/smll.202006000DOI Listing
July 2021

Structure and function of soil bacterial communities in the monoculture and mixed plantation of and in southern subtropical China.

Ying Yong Sheng Tai Xue Bao 2021 Mar;32(3):878-886

Guangxi Key Laboratory of Forest Ecology and Conservation, College of Forestry, Guangxi University, Nanning 530004, China.

Establishing monoculture of native broadleaved tree species and mixed coniferous broadleaved plantations is the tendency for forest management in subtropical China. The variations of structure and function of soil bacterial community in monoculture and mixed tree plantations are still not clear. We examined soil bacterial community structure and function under different soil layers (0-20, 20-40 and 40-60 cm) in three planted forests, including broadleaved coniferous and their mixed plantation, in south subtropical China, using 16S rRNA gene high-throughput sequencing and PICRUSt prediction. The results showed that soil bacterial community structure of mixed plantation and plantation were similar but being significant different from that in plantation. The diversity, biological pathways metabolic function, and nitrogen cycling function of soil bacterial community in plantation were lower than those in plantation and mixed plantation. Soil total nitrogen, nitrate nitrogen and C/N were the main factors driving the variations of soil bacterial community structure and function among different forest types. Our results suggested that the mixed plantation of and is better than plantation in this area in terms of soil bacterial community structure and function.
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http://dx.doi.org/10.13287/j.1001-9332.202103.37DOI Listing
March 2021

Discrepancies among knowledge, practice, and attitudes towards advance care planning among Chinese clinical nurses: A national cross-sectional study.

Appl Nurs Res 2021 04 15;58:151409. Epub 2021 Feb 15.

Administrative Office, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China. Electronic address:

Aims And Objectives: To explore the Chinese nurses' knowledge and attitudes concerning advance care planning (ACP) and their engagement in ACP practice.

Background: Nurses' knowledge, attitude, and practice of ACP are important in promoting ACP in patients, but little is known about knowledge, attitudes, and practice of ACP among nurses in countries where there are no national policies or regulations on ACP.

Design: A descriptive study with a cross-sectional design.

Methods: An online questionnaire survey was distributed to Chinese nurses who attended a national conference.

Results: A total of 531 nurses completed the survey and were included in the final analysis. No nurses answered all questions correctly, while 31 (5.8%) answered all the survey questions wrong. The participants were most knowledgeable about the item "Once ACP is made, the content of advance directives cannot be revoked" and were least knowledgeable about the item "ACP is valid only when the patients are well informed of the medical condition". The implementation of ACP was favored by 92.5% of participants, but only 3.4% of them had actually engaged in all 5 ACP practices listed in the survey. Experience of dealing with death was positively associated with nurses' knowledge concerning ACP. The number of dying patients cared for in the past 6 months, school education of palliative care, knowledge of ACP, and age were related to engagement in the practice of ACP.

Conclusion: Chinese nurses have supportive attitudes towards ACP, but they have limited knowledge and little practice in ACP.
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http://dx.doi.org/10.1016/j.apnr.2021.151409DOI Listing
April 2021

A COVID-19 risk score combining chest CT radiomics and clinical characteristics to differentiate COVID-19 pneumonia from other viral pneumonias.

Aging (Albany NY) 2021 03 13;13(7):9186-9224. Epub 2021 Mar 13.

Medical Physics Program, University of Nevada, Las Vegas, NV 89154, USA.

With the continued transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout the world, identification of highly suspected COVID-19 patients remains an urgent priority. In this study, we developed and validated COVID-19 risk scores to identify patients with COVID-19. In this study, for patient-wise analysis, three signatures, including the risk score using radiomic features only, the risk score using clinical factors only, and the risk score combining radiomic features and clinical variables, show an excellent performance in differentiating COVID-19 from other viral-induced pneumonias in the validation set. For lesion-wise analysis, the risk score using three radiomic features only also achieved an excellent AUC value. In contrast, the performance of 130 radiologists based on the chest CT images alone without the clinical characteristics included was moderate as compared to the risk scores developed. The risk scores depicting the correlation of CT radiomics and clinical factors with COVID-19 could be used to accurately identify patients with COVID-19, which would have clinically translatable diagnostic and therapeutic implications from a precision medicine perspective.
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http://dx.doi.org/10.18632/aging.202735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064216PMC
March 2021

Concordance of PD-L1 Status Between Image-Guided Percutaneous Biopsies and Matched Surgical Specimen in Non-Small Cell Lung Cancer.

Front Oncol 2020 23;10:551367. Epub 2021 Feb 23.

Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China.

Objective: Programmed death-ligand 1 (PD-L1) expression status is a crucial index for identifying patients who will benefit from anti-programmed cell death protein 1 (PD-1)/PD-L1 therapy for non-small cell lung cancer (NSCLC). However, the concordance of Tumor Proportion Score (TPS) between biopsies and matched surgical specimens remains controversial. This study aims to evaluate the concordance of PD-L1 expression between image-guided percutaneous biopsies and matched surgical specimens.

Method: We evaluated 157 patients diagnosed with operable NSCLC on both surgical tissue sections and matched lung biopsies retrospectively. The patients underwent either regular computed tomography (CT)-guided biopsy (n = 82) or positron emission tomography (PET)/CT-guided biopsy (n = 75). The concordance between surgical specimens and lung biopsies for PD-L1 TPS was evaluated using Cohen's kappa (κ) coefficient.

Results: Immunohistochemical expression of PD-L1 was evaluated in both surgical resected specimens and matched biopsies in the eligible 138 patients. The concordance rate of PD-L1 expression between surgical tissue sections and matched biopsies was fairly high at 84.1% (116/138), and the κ value was 0.73 (95% CI: 0.63-0.83, P < 0.001). The concordance rate was higher for tissue sections from PET/CT-guided biopsy than for tissue sections from CT-guided biopsy [88.6% (62/70, κ value: 0.81) vs 79.4% (54/68, κ value: 0.66)].

Conclusion: PD-L1 TPS was strongly concordant between surgical specimens and matched lung biopsies. Thus, the routine evaluation of PD-L1 expression in diagnostic percutaneous biopsies could be reliable for identifying patients who will benefit from anti-PD-1/PD-L1 immunotherapy.
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http://dx.doi.org/10.3389/fonc.2020.551367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940543PMC
February 2021

Involved-Field Irradiation in Definitive Chemoradiotherapy for Locoregional Esophageal Squamous Cell Carcinoma: Results From the ESO-Shanghai 1 Trial.

Int J Radiat Oncol Biol Phys 2021 Aug 5;110(5):1396-1406. Epub 2021 Mar 5.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Purpose: To evaluate the feasibility and efficacy of involved-field irradiation in definitive chemoradiation therapy for locoregional esophageal squamous cell carcinoma.

Methods And Materials: Patterns in recurrence and elective nodal failure were analyzed in patients from the previously published ESO-Shanghai 1 trial, who received definitive chemoradiation therapy with involved-field irradiation to 61.2 Gy in 34 fractions using intensity modulated radiation therapy planning. Nodal regions were delineated using the lymph node map from the sixth edition of the American Joint Committee on Cancer staging system. Elective nodal failure was defined as recurrence in the regional nodal area outside the planning target volume. Extensive elective nodal failure, defined as an extensive nodal area regardless of tumor location, was calculated for additional analysis. The incidental (ie, mean) irradiation dose of each node and each region was evaluated.

Results: With a median follow-up of 48.7 months among survivors, the 3-year actuarial rate for overall survival was 53.6%, and the median overall survival was 44.8 months (95% confidence interval, 34.6-55.0). Of the 436 patients included in this study, 258 patients (59.2%) experienced treatment failure. Elective nodal failure was experienced by 37 patients (8.5%), 7 (1.6%) of whom encountered nodal-only failure. The 3-year actuarial rates of elective nodal control and elective nodal-only control were 89.7% and 97.9%, respectively. The median incidental dose of these nodes was 33.2 Gy (interquartile range [IQR], 1.3-50.7 Gy). The median distance of each node to the planning target volume was 1.4 cm (IQR, 0.6-4.9 cm). Extensive elective nodal failure was experienced by 51 patients (11.6%), and 20 (4.6%) patients had nodal-only failure. The 3-year extensive elective nodal control and extensive elective nodal control-only rates were 86.0% and 94.3%, respectively. The median incidental dose of these nodes was 23.2 Gy (IQR, 1.1-53.5 Gy). The median distance of each node to the planning target volume was 2.0 cm (IQR, 0.6-5.5 cm).

Conclusion: Involved-field irradiation can achieve a low rate of isolated nodal failure and a satisfactory survival outcome. The use of elective nodal irradiation may be unnecessary in definitive chemoradiation therapy for the treatment of locoregional esophageal squamous cell carcinoma.
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http://dx.doi.org/10.1016/j.ijrobp.2021.02.053DOI Listing
August 2021

DNMT3L promotes neural differentiation by enhancing STAT1 and STAT3 phosphorylation independent of DNA methylation.

Prog Neurobiol 2021 Jun 23;201:102028. Epub 2021 Feb 23.

Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning Province, 110122, China. Electronic address:

Previously, we reported global hypermethylation in DS might be attributed to the overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B activities in DNA methylation. To test this hypothesis, we compared the DNA methylation and RNA expression profiles of early-differentiated human neuroprogenitors with and without DNMT3L overexpression. We found DNMT3L overexpression only moderately increased the DNA methylation of limited genes, yet significantly altered global RNA expression of genes involved in neural differentiation. We further found that DNMT3L bound STAT1 or STAT3, and increased its phosphorylation and nuclear translocation, which in turn activated the expression of transcription factors including HES3, ASCL1, NEUROD2 and NEUROG2 and CDK inhibitor CDKN1A, which promoted cell cycle exit and neural differentiation. This phenomenon was also confirmed in Dnmt3l conditional knockin mice, which could be rescued by STAT1 and STAT3 phosphorylation inhibitors (Fludarabine and SH-4-54) but not DNA methylation inhibitor (Decitabine). These results suggest that DNMT3L play an important role during neurodevelopment independent of DNA methylation, which may contribute to the abnormal phenotypes observed in Down syndrome cortex.
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http://dx.doi.org/10.1016/j.pneurobio.2021.102028DOI Listing
June 2021

Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer.

Radiother Oncol 2021 05 20;158:55-61. Epub 2021 Feb 20.

Department of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, China. Electronic address:

Background And Purpose: To compare Ga-fibroblast activation protein inhibitor (FAPI) and F-FDG PET/CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of Ga-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and F-FDG PET/CT.

Materials And Methods: Twenty-one patients with newly diagnosed oesophageal cancer who underwent both F-FDG and Ga-FAPI PET/CT scans were selected. GTVs of the primary tumours based on CE-CT (GTV), PET/CT, and CE-CT plus PET/CT were delineated. Gross tumour lengths were measured by GTVs and endoscopy and recorded.

Results: The Ga-FAPI PET showed significantly higher radiotracer uptake than F-FDG PET (median SUVmax 16.71 vs. 11.23; P = 0.002) in the primary tumours. SUV thresholds of FAPI ×20%, 30%, 40%, and FDG ×40% showed similar lesion lengths compared with that in endoscopic examination (P > 0.05). GTV demonstrated the largest volume (median: 48.80 mm, range: 14.83-162.23 mm) than PET-based GTVs. For PET/CT-guided complementary contouring of GTV, four patients (19%) were increased by FAPI ×20% and 30%, two patients (9.5%) were increased by FAPI ×40%, and only one patient was increased by FDG ×40%. Furthermore, the volume of GTV based on CE-CT plus FAPI ×20%, 30%, and 40% showed no significant difference with GTV and planning target volume based CE-CT plus FAPI-PET and meets the organ at risk standard.

Conclusion: The Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.
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http://dx.doi.org/10.1016/j.radonc.2021.02.015DOI Listing
May 2021

Pentadecanuclear Fe-Containing Polyoxometalate Catalyst for Visible-Light-Driven Generation of Hydrogen.

Inorg Chem 2021 Mar 23;60(6):4124-4132. Epub 2021 Feb 23.

MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, P. R. China.

The structurally new, carbon-free pentadecanuclear Fe-containing polyoxometalate, Na[NaFe(OH)(PO)(A-α-SiWO)]·85HO (Na-), was synthesized using a facile one-pot, solution-based synthetic approach and systematically characterized by various spectroscopic techniques. Single-crystal X-ray diffraction reveals that the title complex is composed of two [Fe(A-α-SiWO)] fragments and two [Fe(A-α-SiWO)] fragments stabilized by four PO linkers in a tetrameric style with idealized point group symmetry. When coupling with (4,4'-di-butyl-2,2'-dipyridyl)-bis(coumarin)-iridium(III) hexafluorophosphate ([Ir(coumarin)(dtbbpy)][PF]) photosensitizer and triethanolamine (TEOA) sacrificial electron donor, polyoxoanion effectively catalyzed hydrogen production with a minimally optimized TON of 986, which represents, to our knowledge, one of the highest values among known Fe-substituted POM-catalyzed hydrogen production systems. Both a mercury-poisoning test and FT-IR characterizations proved the structural stability of catalyst under photocatalytic conditions. The photocatalytic mechanism of the present hydrogen-evolving system was investigated by time-solved luminescence and static emission quenching measurements.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00267DOI Listing
March 2021

A novel predict factor that increases the success rate of methotrexate treatment in fallopian tube pregnancy.

Ann Transl Med 2021 Jan;9(2):146

International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai, China.

Background: For stable fallopian tube pregnancy (FTP), methotrexate (MTX) therapy is reported to be as effective as laparoscopy. However, some cases would need further treatment, e.g., another dose of MTX or laparoscopy. This study is to investigate the potential factors during the treatment of FTP that may facilitate the prediction of a successful outcome of MTX therapy.

Methods: All FTP cases admitted to the International Peace Maternal and Child Health Hospital (IPMCH), Shanghai, China from January 2016 to December 2017 were reviewed. All patients received a single dose of 50 mg/m MTX prior to other treatment. Statistical analysis was performed to determine the correlation between clinical parameters and the success rate of MTX treatment.

Results: The success rate of single-dose MTX was 77.53%. The serum beta-human chorionic gonadotropin (β-hCG) level cut-off value was 452.64 IU/L, with a specificity of 76.7% and sensitivity of 43% [area under the receiver operating characteristic curve (AUC) 0.803; P<0.0001]. In addition, serum β-hCG levels and patient age correlated with the success rate of MTX treatment.

Conclusions: Lower β-hCG levels led to successful MTX treatment for FTP, with a cutoff value of 452.64 IU/L. Younger patients were more sensitive to MTX treatment. These results may help clinicians when deciding the potential therapy for patients with tubal ectopic pregnancies.
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http://dx.doi.org/10.21037/atm-20-7914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867891PMC
January 2021

Chemotherapy Plus Radiotherapy Versus Radiotherapy in Patients With Small Cell Carcinoma of the Esophagus: A SEER Database Analysis.

Cancer Control 2021 Jan-Dec;28:1073274821989321

Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China.

Background: Small cell carcinoma of the esophagus is a rare malignant tumor. We aimed to explore the chemotherapeutic efficacy on the prognosis of patients with small cell carcinoma of the esophagus who received radiotherapy.

Methods: To identify the population of interest, Surveillance, Epidemiology, and End Results data from 1996 to 2016 were chosen. Univariate and multivariate analyses were used to probe into prognosis factors. Multivariate Cox regression analysis was conducted to identify factors related to overall survival and cancer-specific survival.

Results: Overall, data from 162 patients were analyzed in this study. Tumor size (P = 0.014), T staging (P = 0.028), and chemotherapy (P < 0.001) were independent prognostic factors affecting overall survival. Patients with regional disease (hazard ratio = 5.435, P < 0.001) and distant metastasis (hazard ratio = 2.183, P < 0.001) who received radiotherapy alone had worse survival than those receiving chemoradiotherapy. Tumor size (P = 0.004) and chemotherapy (P < 0.001) were independent prognostic factors affecting cancer-specific survival. Tumor size was an independent factor affecting cancer-specific survival for patients receiving chemoradiation.

Conclusions: Age, T staging, tumor size, primary site, and chemotherapy are independent prognosis factors affecting overall survival and cancer-specific survival in patients with small cell carcinoma of the esophagus who receive radiotherapy. Chemotherapy might further improve cancer-specific survival in patients with small cell carcinoma of the esophagus receiving radiotherapy at all stages.
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http://dx.doi.org/10.1177/1073274821989321DOI Listing
February 2021

Heterogeneity of Paucigranulocytic Asthma: A Prospective Cohort Study with Hierarchical Cluster Analysis.

J Allergy Clin Immunol Pract 2021 06 20;9(6):2344-2355. Epub 2021 Jan 20.

Priority Research Center for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.

Background: Asthma, a heterogeneous disease, can be divided into 4 inflammatory phenotypes using induced sputum cell counts-eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma, and paucigranulocytic asthma (PGA). Although research has focused on EA and NA, there is little known about PGA.

Objective: To study the heterogeneity of PGA and identify possible PGA clusters to guide clinical treatment.

Methods: Patients with PGA were grouped by hierarchical cluster analysis and enrolled into a prospective cohort study to validate the clusters, relative to future risk of asthma exacerbations in a real-world setting. Clusters were validated by tree analysis in a separate population. Finally, we explored PGA stability.

Results: Cluster analysis of 145 patients with PGA identified 3 clusters: cluster 1 (n = 110, 75.9%) was "mild PGA," cluster 2 (n = 20, 13.8%) was "PGA with psychological dysfunction and rhinoconjunctivitis and other allergic diseases," and cluster 3 (n = 15, 10.3%) was "smoking-associated PGA." Cluster 3 had significantly increased risk of severe exacerbation (relative risk [RR] = 6.43, P = .01), emergency visit (RR = 8.61, P = .03), and hospitalization (RR = 12.94, P < .01). Results of the cluster analysis were successfully validated in an independent PGA population classified using decision tree analysis. Although PGA can transform into or develop from other phenotypes, 70% were stable over time.

Conclusions: Among 3 identified PGA clusters, cluster 3 had a higher risk of severe exacerbation. PGA heterogeneity indicates the requirement of novel targeted interventions.
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http://dx.doi.org/10.1016/j.jaip.2021.01.004DOI Listing
June 2021

Quantity of supplementary LED lightings regulates photosynthetic apparatus, improves photosynthetic capacity and enhances productivity of Cos lettuce grown in a tropical greenhouse.

Photosynth Res 2021 Jan 21. Epub 2021 Jan 21.

Natural Sciences & Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore.

Although cooling their rootzone allows year-round (temperate) vegetable production in Singapore's warm climate, these crops have frequently experienced increasingly unpredictable cloudy and hazy weather. Supplementary lighting with light-emitting diodes (LEDs) could be used to reduce the impacts of low light intensity. This study investigated the responses of temperate Cos lettuce (Lactuca sativa L.) to different quantities (photosynthetic photon flux density, PPFD of 0, 150, 300 µmol m s) of supplementary LED lightings in the tropical greenhouse. Increasing light intensity significantly increased total leaf area, shoot and root fresh weight (FW) and dry weight (DW), total chlorophyll (Chl) and carotenoids (Car) contents, light-saturated photosynthetic CO assimilation rate (A) and transpiration rate (T). There were no significant differences in F/F ratio, total reduced nitrogen, specific leaf area (SLA) and PSII concentration among the three light treatments. However, there was an increasing trend with increasing light intensity for Chl a/b ratio, net photosynthetic O evolution rate (P), cytochrome bf (Cyt bf), leaf total soluble protein and Rubisco concentrations. This study provides the basic understanding of photosynthetic apparatus and capacity of temperate crops grown under different supplementary LED lightings in the tropical greenhouse.
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http://dx.doi.org/10.1007/s11120-020-00816-wDOI Listing
January 2021

Role of [Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of peritoneal carcinomatosis and comparison with [F]-FDG PET/CT.

Eur J Nucl Med Mol Imaging 2021 06 7;48(6):1944-1955. Epub 2021 Jan 7.

Department of Nuclear Medicine & Minnan PET Center, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Purpose: The aim of this study was to explore the role of [Ga]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT), compared with F-fluorodeoxyglucose [F]-FDG PET/CT, for evaluating peritoneal carcinomatosis in patients with various types of cancer.

Methods: Patients with suspected peritoneal malignancy, who underwent both [F]-FDG and [Ga]Ga-DOTA-FAPI-04 PET/CT between October 2019 and August 2020, were retrospectively analysed. The radiotracer uptake, peritoneal cancer index (PCI) score, and diagnostic performance of [F]-FDG and [Ga]Ga-DOTA-FAPI-04 PET/CT were evaluated and compared.

Results: Our cohort consisted of 46 patients, including 16 patients with diffuse-type peritoneal carcinomatosis, 27 with nodular-type peritoneal carcinomatosis, and 3 true-negative patients. A significant difference in standard uptake values (SUV) of lesions between [F]-FDG and [Ga]Ga-DOTA-FAPI-04 PET/CT examination was observed (median SUV: 3.48 vs. 9.82; P < 0.001), particularly in peritoneal carcinomatosis from gastric cancer (median SUV: 3.44 vs. 8.05; P = 0.001). Moreover, [Ga]Ga-DOTA-FAPI-04 PET/CT showed a higher PCI score and better sensitivity than [F]-FDG PET/CT for the detection of peritoneal carcinomatosis (6 vs. 18; P < 0.001; 72.09% vs. 97.67%; P = 0.002).

Conclusion: [Ga]Ga-DOTA-FAPI-04 PET/CT demonstrated superior sensitivity over [F]-FDG PET/CT for the detection of peritoneal carcinomatosis in patients with various types of cancer, particularly gastric cancer. Furthermore, the uptake of [Ga]Ga-DOTA-FAPI-04 in peritoneal carcinomatosis was significantly higher than that of [F]-FDG, demonstrating a larger extent of the lesions and yielding a higher PCI score. This could help enhance the image contrast, improve physicians' diagnostic confidence, and reduce the proportion of missed diagnoses.
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http://dx.doi.org/10.1007/s00259-020-05146-6DOI Listing
June 2021
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