Qihan Li

Qihan Li

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Reducing Viral Inhibition of Host Cellular Apoptosis Strengthens the Immunogenicity and Protective Efficacy of an Attenuated HSV-1 Strain.

Virol Sin 2019 Sep 10. Epub 2019 Sep 10.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China.

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http://dx.doi.org/10.1007/s12250-019-00156-7DOI Listing
September 2019

Herpes Simplex Virus Type 1-Encoded miR-H2-3p Manipulates Cytosolic DNA-Stimulated Antiviral Innate Immune Response by Targeting DDX41.

Viruses 2019 Aug 15;11(8). Epub 2019 Aug 15.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.3390/v11080756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723821PMC
August 2019

Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development.

Rev Med Virol 2019 Jul 13;29(4):e2054. Epub 2019 Jun 13.

Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.1002/rmv.2054DOI Listing
July 2019

Correction to: Hospital Cirrhosis Volume and Readmission in Patients with Cirrhosis in California.

Dig Dis Sci 2019 May;64(5):1392-1394

Department of Gastroenterology, Kaiser Permanente, Northern California, San Francisco, CA, USA.

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http://link.springer.com/10.1007/s10620-019-05558-x
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http://dx.doi.org/10.1007/s10620-019-05558-xDOI Listing
May 2019

microRNA-4516 Contributes to Different Functions of Epithelial Permeability Barrier by Targeting Poliovirus Receptor Related Protein 1 in Enterovirus 71 and Coxsackievirus A16 Infections.

Front Cell Infect Microbiol 2018 9;8:110. Epub 2018 Apr 9.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China.

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http://journal.frontiersin.org/article/10.3389/fcimb.2018.00
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http://dx.doi.org/10.3389/fcimb.2018.00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900049PMC
April 2019

Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen.

NPJ Vaccines 2019 27;4:14. Epub 2019 Mar 27.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, 650118 Kunming, Yunnan China.

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http://www.nature.com/articles/s41541-019-0108-6
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http://dx.doi.org/10.1038/s41541-019-0108-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437170PMC
March 2019

Immunogenicity and Safety of an F-Genotype Attenuated Mumps Vaccine in Healthy 8- to 24-Month-Old Children.

J Infect Dis 2019 Jan;219(1):50-58

Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China.

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http://dx.doi.org/10.1093/infdis/jiy469DOI Listing
January 2019

Association of human leukocyte antigen alleles and supertypes with immunogenicity of oral rotavirus vaccine given to infants in China.

Medicine (Baltimore) 2018 Oct;97(40):e12706

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming.

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http://dx.doi.org/10.1097/MD.0000000000012706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200448PMC
October 2018

Hospital Cirrhosis Volume and Readmission in Patients with Cirrhosis in California.

Dig Dis Sci 2018 Sep 19;63(9):2267-2274. Epub 2018 Feb 19.

Department of Gastroenterology, Kaiser Permanente, Northern California, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s10620-018-4964-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097881PMC
September 2018

miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9.

Emerg Microbes Infect 2018 Sep 19;7(1):155. Epub 2018 Sep 19.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China.

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http://dx.doi.org/10.1038/s41426-018-0157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143596PMC
September 2018

Immune Evasion of Enteroviruses Under Innate Immune Monitoring.

Front Microbiol 2018 14;9:1866. Epub 2018 Aug 14.

Institute of Medical Biology, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.3389/fmicb.2018.01866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102382PMC
August 2018

Correction: C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.

Cell Death Dis 2018 Jul 16;9(8):789. Epub 2018 Jul 16.

Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/s41419-018-0834-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048141PMC
July 2018

[Sorting and identification of human immature Langerhans cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Jul;34(7):577-582

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China. *Corresponding author, E-mail:

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July 2018

Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque.

Viruses 2018 05 2;10(5). Epub 2018 May 2.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.3390/v10050234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977227PMC
May 2018

Immune mechanisms induced by an HSV-1 mutant strain: Discrepancy analysis of the immune system gene profile in comparison with a wild-type strain.

Vaccine 2018 04 27;36(18):2394-2402. Epub 2018 Mar 27.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2018.03.056DOI Listing
April 2018

Dynamic Interaction of Enterovirus 71 and Dendritic Cells in Infected Neonatal Rhesus Macaques.

Front Cell Infect Microbiol 2017 10;7:171. Epub 2017 May 10.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming, China.

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http://dx.doi.org/10.3389/fcimb.2017.00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423916PMC
January 2018

RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein.

BMC Immunol 2018 01 25;19(1). Epub 2018 Jan 25.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 935 Jiaoling Road, Kunming, Yunnan, 650118, China.

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http://dx.doi.org/10.1186/s12865-018-0240-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784715PMC
January 2018

Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis.

Am J Transl Res 2018 15;10(1):212-223. Epub 2018 Jan 15.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801359PMC
January 2018

Attenuated phenotypes and analysis of a herpes simplex virus 1 strain with partial deletion of the UL7, UL41 and LAT genes.

Virol Sin 2017 Oct 29;32(5):404-414. Epub 2017 Sep 29.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development of Severe Infectious Disease, Kunming, 650118, China.

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http://dx.doi.org/10.1007/s12250-017-3947-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598894PMC
October 2017

Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral , , and Genes.

Front Microbiol 2017 9;8:1958. Epub 2017 Oct 9.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.3389/fmicb.2017.01958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640706PMC
October 2017

C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.

Cell Death Dis 2017 10 26;8(10):e3146. Epub 2017 Oct 26.

Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/cddis.2017.560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680925PMC
October 2017

The Preferential Infection of Astrocytes by Enterovirus 71 Plays a Key Role in the Viral Neurogenic Pathogenesis.

Front Cell Infect Microbiol 2016 21;6:192. Epub 2016 Dec 21.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College Kunming, China.

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http://dx.doi.org/10.3389/fcimb.2016.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174126PMC
August 2017

Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E.

J Virol 2017 08 12;91(15). Epub 2017 Jul 12.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China

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http://dx.doi.org/10.1128/JVI.02227-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512249PMC
August 2017

Immune Serum From Sabin Inactivated Poliovirus Vaccine Immunization Neutralizes Multiple Individual Wild and Vaccine-Derived Polioviruses.

Clin Infect Dis 2017 May;64(10):1317-1325

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan.

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http://dx.doi.org/10.1093/cid/cix110DOI Listing
May 2017

Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets.

Cell Host Microbe 2017 Mar;21(3):334-343

Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.02.007DOI Listing
March 2017

Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication.

Front Immunol 2017 10;8:117. Epub 2017 Feb 10.

School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences , Beijing , China.

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http://dx.doi.org/10.3389/fimmu.2017.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300993PMC
February 2017

Pathologic and immunologic characteristics of coxsackievirus A16 infection in rhesus macaques.

Virology 2017 01 6;500:198-208. Epub 2016 Nov 6.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan, China. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.10.031DOI Listing
January 2017

Comparison analysis of microRNAs in response to EV71 and CA16 infection in human bronchial epithelial cells by high-throughput sequencing to reveal differential infective mechanisms.

Virus Res 2017 01 24;228:90-101. Epub 2016 Nov 24.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2016.11.024DOI Listing
January 2017

CTCF interacts with the lytic HSV-1 genome to promote viral transcription.

Sci Rep 2017 01 3;7:39861. Epub 2017 Jan 3.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &Yunnan Province, Kunming Institute of Zoology, Kunming, Kunming 650223, China.

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http://dx.doi.org/10.1038/srep39861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206630PMC
January 2017

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features.

Viruses 2017 01 30;9(2). Epub 2017 Jan 30.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China.

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http://dx.doi.org/10.3390/v9020026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332945PMC
January 2017

Phase 3 Trial of a Sabin Strain-Based Inactivated Poliovirus Vaccine.

J Infect Dis 2016 Dec 22;214(11):1728-1734. Epub 2016 Sep 22.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming.

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http://dx.doi.org/10.1093/infdis/jiw433DOI Listing
December 2016

Different microRNA alterations contribute to diverse outcomes following EV71 and CA16 infections: Insights from high-throughput sequencing in rhesus monkey peripheral blood mononuclear cells.

Int J Biochem Cell Biol 2016 12 17;81(Pt A):20-31. Epub 2016 Oct 17.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.10.011DOI Listing
December 2016

Mumps virus induces innate immune responses in mouse ovarian granulosa cells through the activation of Toll-like receptor 2 and retinoic acid-inducible gene I.

Mol Cell Endocrinol 2016 11 28;436:183-94. Epub 2016 Jul 28.

School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.07.033DOI Listing
November 2016

The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription.

Virol J 2016 09 13;13:152. Epub 2016 Sep 13.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development of Severe Infectious Disease, Kunming, Yunnan, China.

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http://dx.doi.org/10.1186/s12985-016-0600-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020468PMC
September 2016

Dynamic Constitution of the Pathogens Inducing Encephalitis in Hand, Foot and Mouth Disease in Kunming, 2009-2011.

Jpn J Infect Dis 2015 10;68(6):504-10. Epub 2015 Apr 10.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College.

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http://dx.doi.org/10.7883/yoken.JJID.2014.428DOI Listing
August 2016

The Structure, Pathogenicity and Immunogenicity of Two Virion Fractions Harvested from Cell Cultures Infected with the CA16 Virus.

Intervirology 2015 31;58(4):260-9. Epub 2015 Oct 31.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China.

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http://dx.doi.org/10.1159/000440722DOI Listing
August 2016

Immunization against TGF-β1 reduces collagen deposition but increases sustained inflammation in a murine asthma model.

Hum Vaccin Immunother 2016 07 22;12(7):1876-85. Epub 2016 Feb 22.

c Department of Pediatrics and Child Health , University of Manitoba , Winnipeg , Canada.

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http://dx.doi.org/10.1080/21645515.2016.1145849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964826PMC
July 2016

Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children.

Glob Pediatr Health 2016 27;3:2333794X16643723. Epub 2016 May 27.

Institute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, China.

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http://dx.doi.org/10.1177/2333794X16643723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905128PMC
June 2016

HSV-1 tegument protein and the development of its genome editing technology.

Virol J 2016 06 24;13:108. Epub 2016 Jun 24.

Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, China.

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http://dx.doi.org/10.1186/s12985-016-0563-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919851PMC
June 2016

Preparation and characterization of amine-functionalized sugarcane bagasse for CO2 capture.

J Environ Manage 2016 Mar 17;168:142-8. Epub 2015 Dec 17.

PCFM Lab, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China.

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http://dx.doi.org/10.1016/j.jenvman.2015.09.033DOI Listing
March 2016

Global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD.

Virus Res 2016 Mar 8;214:1-10. Epub 2016 Jan 8.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2016.01.002DOI Listing
March 2016

Biological characteristics of different epidemic enterovirus 71 strains and their pathogeneses in neonatal mice and rhesus monkeys.

Virus Res 2016 Feb 10;213:82-89. Epub 2015 Nov 10.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01681702153011
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http://dx.doi.org/10.1016/j.virusres.2015.11.007DOI Listing
February 2016

Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy.

Sci Rep 2016 Feb 29;6:22303. Epub 2016 Feb 29.

Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming 650118, PR China.

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http://dx.doi.org/10.1038/srep22303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770412PMC
February 2016

Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System.

J Virol 2016 01 28;90(2):790-804. Epub 2015 Oct 28.

Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China

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http://dx.doi.org/10.1128/JVI.02258-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702684PMC
January 2016

Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells.

Sci Rep 2016 Jan 18;6:19507. Epub 2016 Jan 18.

School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China.

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http://dx.doi.org/10.1038/srep19507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725973PMC
January 2016

A severe case of co-infection with Enterovirus 71 and vaccine-derived Poliovirus type II.

J Clin Virol 2015 Nov 3;72:25-9. Epub 2015 Sep 3.

Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2015.08.017DOI Listing
November 2015

Similar protective immunity induced by an inactivated enterovirus 71 (EV71) vaccine in neonatal rhesus macaques and children.

Vaccine 2015 Nov 28;33(46):6290-7. Epub 2015 Sep 28.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.09.047DOI Listing
November 2015

Phylogenetic analysis of Newcastle disease viruses isolated from wild birds in the Poyang Lake region of China.

J Vet Med Sci 2015 Sep 3;77(9):1143-9. Epub 2015 Apr 3.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, PR China.

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http://dx.doi.org/10.1292/jvms.14-0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591157PMC
September 2015

Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line.

Hum Vaccin Immunother 2014 28;10(5):1266-73. Epub 2014 Feb 28.

Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases; Institute of Medical Biology; Chinese Academy of Medicine Sciences & Peking Union Medical College; Kunming, PR China.

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http://dx.doi.org/10.4161/hv.28083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896597PMC
June 2015

HIV-1 vaccines based on replication-competent Tiantan vaccinia protected Chinese rhesus macaques from simian HIV infection.

AIDS 2015 Mar;29(6):649-58

aState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention bNational Institutes for Food and Drug Control, Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, Beijing cCollege of Life Science, Nankai University, Tianjin dInstitute of Medical Biology, CAMS, Kunming eInstitute of Laboratory Animal Sciences, CAMS, Beijing fCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. *Drs Qiang Liu, Yue Li and Zhenwu Luo contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/QAD.0000000000000595DOI Listing
March 2015

Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.

Part Fibre Toxicol 2015 Mar 7;12. Epub 2015 Mar 7.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, 100005, China.

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http://particleandfibretoxicology.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s12989-015-0080-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395934PMC
March 2015

The gene expression profile of peripheral blood mononuclear cells from EV71-infected rhesus infants and the significance in viral pathogenesis.

PLoS One 2014 2;9(1):e83766. Epub 2014 Jan 2.

Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879270PMC
November 2014

HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane protein 140.

Virology 2014 Sep 16;464-465:1-10. Epub 2014 Jul 16.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.06.034DOI Listing
September 2014

Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36.

J Acquir Immune Defic Syndr 2014 Aug;66(5):473-83

*Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY; †Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China; and ‡Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/QAI.0000000000000218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163016PMC
August 2014

[Heat effect stability of inactivated enterovirus 71 vaccine].

Zhonghua Yu Fang Yi Xue Za Zhi 2014 Aug;48(8):726-30

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Kunming 650118, China. Email:

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August 2014

The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes.

PLoS One 2013 15;8(11):e79648. Epub 2013 Nov 15.

Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College, Kunming, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829861PMC
July 2014

Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys.

Vaccine 2014 Jul 21;32(35):4436-42. Epub 2014 Jun 21.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, 935 Jiaoling Road, Kunming 650118, Yunnan, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.06.062DOI Listing
July 2014

High-efficiency targeted editing of large viral genomes by RNA-guided nucleases.

PLoS Pathog 2014 May 1;10(5):e1004090. Epub 2014 May 1.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development of Severe Infectious Disease, Kunming, Yunnan, China.

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http://dx.doi.org/10.1371/journal.ppat.1004090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006927PMC
May 2014

Dynamic profiles of neutralizing antibody responses elicited in rhesus monkeys immunized with a combined tetravalent DTaP-Sabin IPV candidate vaccine.

Vaccine 2014 Feb 7;32(9):1100-6. Epub 2014 Jan 7.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease, Kunming 650118, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2013.12.025DOI Listing
February 2014

An inactivated enterovirus 71 vaccine in healthy children.

N Engl J Med 2014 Feb;370(9):829-37

From Guangxi Province Center for Disease Control and Prevention, Nanning (R.L., Z.M., Y. Li, T.H., Y.N.), Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming (L.L., Y.Z., Jingjing Wang, L.J., C.D., Y.C., Z.X., L.W., Y. Liao, Y. Liang, J.L., H.Z., R.N., L.G., J.P., E.Y., L.S., P.C., H.S., Q.L.), Key Laboratory Medical Molecular Virology, Ministries of Education and Health, and the Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai (X.W.), Department of Health Statistics, Fourth Military Medical University, Xi'an (J.X., Z.J.), and National Institutes for Food and Drug Control, Beijing (Z.L., Q.M., Junzhi Wang) - all in China.

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http://dx.doi.org/10.1056/NEJMoa1303224DOI Listing
February 2014

PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes.

Virol Sin 2013 Dec 6;28(6):345-51. Epub 2013 Nov 6.

Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College, Kunming, 650118, China.

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http://dx.doi.org/10.1007/s12250-013-3350-5DOI Listing
December 2013

A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5.

Sci China Life Sci 2013 Dec 5;56(12):1124-33. Epub 2013 Dec 5.

Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 650118, China.

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http://link.springer.com/content/pdf/10.1007/s11427-013-4569
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http://dx.doi.org/10.1007/s11427-013-4569-yDOI Listing
December 2013

Genetic variability in L1 and L2 genes of HPV-16 and HPV-58 in Southwest China.

PLoS One 2013 25;8(1):e55204. Epub 2013 Jan 25.

Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555822PMC
July 2013

EV71-infected CD14(+) cells modulate the immune activity of T lymphocytes in rhesus monkeys.

Emerg Microbes Infect 2013 Jul 24;2(7):e44. Epub 2013 Jul 24.

Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, , Kunming 650118, China.

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http://dx.doi.org/10.1038/emi.2013.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820984PMC
July 2013

A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes.

Sci China Life Sci 2013 Apr 20;56(4):373-83. Epub 2013 Mar 20.

Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.1007/s11427-013-4458-4DOI Listing
April 2013

The miRNAs of herpes simplex virus (HSV).

Authors:
Le Sun Qihan Li

Virol Sin 2012 Dec 9;27(6):333-8. Epub 2012 Nov 9.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.1007/s12250-012-3266-5DOI Listing
December 2012

Analysis of the Th1/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys.

J Clin Immunol 2012 Oct 15;32(5):1048-58. Epub 2012 May 15.

Institute Of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, 935# Jiaoling Rd, Kunming, 650118, People's Republic of China.

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http://dx.doi.org/10.1007/s10875-012-9690-3DOI Listing
October 2012

The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates.

Virology 2012 Oct 21;432(2):417-26. Epub 2012 Jul 21.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan 650118, PR China.

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http://dx.doi.org/10.1016/j.virol.2012.06.026DOI Listing
October 2012

A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B).

Sci China Life Sci 2012 Apr 9;55(4):336-42. Epub 2012 May 9.

Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, China.

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http://dx.doi.org/10.1007/s11427-012-4313-zDOI Listing
April 2012

Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial.

J Infect Dis 2012 Jan 8;205(2):237-43. Epub 2011 Dec 8.

Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.1093/infdis/jir723DOI Listing
January 2012

Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines.

Vaccine 2011 Dec 19;29(52):9668-74. Epub 2011 Oct 19.

National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, PR China.

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http://dx.doi.org/10.1016/j.vaccine.2011.10.018DOI Listing
December 2011

Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009.

J Med Microbiol 2011 Oct 16;60(Pt 10):1496-501. Epub 2011 Jun 16.

Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.

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http://dx.doi.org/10.1099/jmm.0.021907-0DOI Listing
October 2011

Pathogenesis study of enterovirus 71 infection in rhesus monkeys.

Lab Invest 2011 Sep 9;91(9):1337-50. Epub 2011 May 9.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, People's Republic of China.

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http://dx.doi.org/10.1038/labinvest.2011.82DOI Listing
September 2011

Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys.

Vaccine 2011 Aug 29;29(37):6269-75. Epub 2011 Jun 29.

Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.

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http://dx.doi.org/10.1016/j.vaccine.2011.06.044DOI Listing
August 2011

The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells.

J Mol Cell Biol 2011 Aug;3(4):221-9

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Tsinghua University, Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1093/jmcb/mjr017DOI Listing
August 2011

Preparation of an ion-imprinted fiber for the selective removal of Cu2+.

Langmuir 2011 Jun 10;27(11):6753-8. Epub 2011 May 10.

PCFM Lab, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China.

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http://dx.doi.org/10.1021/la200986vDOI Listing
June 2011

HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2.

Sci China Life Sci 2011 Apr 21;54(4):359-65. Epub 2011 Apr 21.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.1007/s11427-011-4160-3DOI Listing
April 2011

Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection.

Virology 2011 Mar 22;412(1):91-100. Epub 2011 Jan 22.

Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, 379 Jiaoling Road, Kunming, Yunnan, PR China.

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http://dx.doi.org/10.1016/j.virol.2010.12.058DOI Listing
March 2011

Identification and development of a promising novel mumps vaccine candidate strain.

Microbes Infect 2010 Dec 25;12(14-15):1178-87. Epub 2010 Aug 25.

Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, 379# Jiaoling Road, Kunming 650118, PR China.

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http://dx.doi.org/10.1016/j.micinf.2010.08.004DOI Listing
December 2010

Significant elevation of B cells at the acute stage in enterovirus 71-infected children with central nervous system involvement.

Scand J Infect Dis 2010 Dec 18;42(11-12):931-5. Epub 2010 Oct 18.

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.3109/00365548.2010.498018DOI Listing
December 2010

Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys.

Hum Vaccin 2010 Dec 1;6(12):1028-37. Epub 2010 Dec 1.

Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, PR China.

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http://dx.doi.org/10.4161/hv.6.12.12982DOI Listing
December 2010

Preparation and characterization of a solid amine adsorbent for capturing CO2 by grafting allylamine onto PAN fiber.

Langmuir 2010 Sep;26(17):13897-902

PCFM Lab, OFCM Institute, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China.

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http://dx.doi.org/10.1021/la101281vDOI Listing
September 2010

Herpes simplex virus type 1 tegument protein VP22 is capable of modulating the transcription of viral TK and gC genes via interaction with viral ICP0.

Biochimie 2010 Aug 10;92(8):1024-30. Epub 2010 May 10.

Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118, PR China.

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http://dx.doi.org/10.1016/j.biochi.2010.04.025DOI Listing
August 2010

Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.

Virol J 2010 Jul 14;7:156. Epub 2010 Jul 14.

Institute Of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118, P. R. China.

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http://dx.doi.org/10.1186/1743-422X-7-156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913958PMC
July 2010

The transactivating effect of HSV-1 ICP0 is enhanced by its interaction with the PCAF component of histone acetyltransferase.

Arch Virol 2009 7;154(11):1755-64. Epub 2009 Oct 7.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College, Kunming, Yunnan, China.

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http://dx.doi.org/10.1007/s00705-009-0516-4DOI Listing
February 2010

Transcriptional regulation of the Herpes Simplex Virus 1alpha-gene by the viral immediate-early protein ICP22 in association with VP16.

Sci China C Life Sci 2009 Apr 21;52(4):344-51. Epub 2009 Apr 21.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.

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http://dx.doi.org/10.1007/s11427-009-0051-2DOI Listing
April 2009

Functional analysis of transcriptional regulation of herpes simplex virus type 1 tegument protein VP22.

Sci China C Life Sci 2008 Nov 7;51(11):966-72. Epub 2008 Nov 7.

Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China.

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http://dx.doi.org/10.1007/s11427-008-0127-4DOI Listing
November 2008

Complete genome sequencing and phylogenetic analysis of HCV isolates from China reveals a new subtype, designated 6u.

J Med Virol 2008 Oct;80(10):1740-6

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunan, China.

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http://dx.doi.org/10.1002/jmv.21287DOI Listing
October 2008

Immunogenicity and safety of a novel formalin-inactivated and alum-adjuvanted candidate subunit vaccine for mumps.

Vaccine 2008 Aug 11;26(33):4276-83. Epub 2008 Jun 11.

Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, 379# Jiaoling Road, Kunming 650118 PR China.

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http://dx.doi.org/10.1016/j.vaccine.2008.05.060DOI Listing
August 2008

Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus.

Viral Immunol 2008 Jun;21(2):153-62

Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming, China.

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http://dx.doi.org/10.1089/vim.2007.0108DOI Listing
June 2008

Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2.

Sci China C Life Sci 2007 Aug;50(4):473-8

Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.

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http://dx.doi.org/10.1007/s11427-007-0039-8DOI Listing
August 2007

Analysis of HSV-I ICP22 effects on HCMV major immediate-early promoter structure.

Sci China C Life Sci 2007 Jun;50(3):292-7

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China.

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http://dx.doi.org/10.1007/s11427-007-0041-1DOI Listing
June 2007

Immunization with a synthetic multiepitope antigen induces humoral and cellular immune responses to hepatitis C virus in mice.

Viral Immunol 2007 ;20(1):170-9

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1089/vim.2006.0067DOI Listing
May 2007