Publications by authors named "Qianqian Huang"

67 Publications

Enhanced Microwave Absorbing Ability of Carbon Fibers with Embedded FeCo/CoFeO Nanoparticles.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China.

In the face of increasingly severe electromagnetic (EM) wave pollution, the research of EM wave absorbing materials is an effective solution. To reduce the density of traditional absorbing materials, in this work, FeCo/CoFeO/carbon nanofiber composites were successfully prepared by electrospinning for the EM wave attenuation application. Benefiting from the loss ability of interface polarization, dipole polarization, and magnetic loss, the composites obtained a bandwidth of 5.0 GHz at a 1.95 mm thickness and an absorption peak of -52.3 dB. More importantly, the radar cross section (RCS) reduction of composite coatings calculated by ANSYS Electronics Desktop 2018 (HFSS) can reach 34.5 dBm, and the RCS value is almost less than -10 dBm when the incident angle is greater than 20°, demonstrating great scattering ability of the material coating to EM waves. This work, combined with the exploration of the mechanism and the simulation analysis of the absorbing coating, will be of significance for the development of absorbing materials.
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http://dx.doi.org/10.1021/acsami.1c09430DOI Listing
July 2021

Environmentally Friendly and Multifunctional Shaddock Peel-Based Carbon Aerogel for Thermal-Insulation and Microwave Absorption.

Nanomicro Lett 2021 Apr 5;13(1):102. Epub 2021 Apr 5.

College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, People's Republic of China.

Highlights: The eco-friendly shaddock peel-derived carbon aerogels were prepared by a freeze-drying method. Multiple functions such as thermal insulation, compression resistance and microwave absorption can be integrated into one material-carbon aerogel. Novel computer simulation technology strategy was selected to simulate significant radar cross-sectional reduction values under real far field condition. . Eco-friendly electromagnetic wave absorbing materials with excellent thermal infrared stealth property, heat-insulating ability and compression resistance are highly attractive in practical applications. Meeting the aforesaid requirements simultaneously is a formidable challenge. Herein, ultra-light carbon aerogels were fabricated via fresh shaddock peel by facile freeze-drying method and calcination process, forming porous network architecture. With the heating platform temperature of 70 °C, the upper surface temperatures of the as-prepared carbon aerogel present a slow upward trend. The color of the sample surface in thermal infrared images is similar to that of the surroundings. With the maximum compressive stress of 2.435 kPa, the carbon aerogels can provide favorable endurance. The shaddock peel-based carbon aerogels possess the minimum reflection loss value (RL) of - 29.50 dB in X band. Meanwhile, the effective absorption bandwidth covers 5.80 GHz at a relatively thin thickness of only 1.7 mm. With the detection theta of 0°, the maximum radar cross-sectional (RCS) reduction values of 16.28 dB m can be achieved. Theoretical simulations of RCS have aroused extensive interest owing to their ingenious design and time-saving feature. This work paves the way for preparing multi-functional microwave absorbers derived from biomass raw materials under the guidance of RCS simulations.
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http://dx.doi.org/10.1007/s40820-021-00635-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021664PMC
April 2021

Nonlinearity managed passively harmonic mode-locked Er-doped fiber laser based on carbon nanotube film.

Opt Lett 2021 Jun;46(11):2638-2641

We examine the implication of intracavity nonlinearity for harmonic mode locking (HML) by exploiting highly nonlinear fiber in a carbon nanotube film mode-locked Er-doped fiber laser. It is found that the reasonably large nonlinearity is of benefit to increase the extent of harmonic order while the excessive nonlinearity leads to some peculiar multi-pulse patterns such as noise-like pulse and soliton rain. Via appropriate nonlinearity management, nearly 4 GHz repetition rate pulses at the 91st harmonic with 936 fs pulse duration are delivered under the pump power of 280 mW. The pulse stability is evidenced by the super-mode suppression ratio of 35.6 dB. To the best of our knowledge, it is the highest repetition rate yet reported for a passively HML fiber laser based on a film-type physical saturable absorber. Furthermore, the laser exhibits steep pumping efficiency slope of ${\gt}{19}\;{\rm MHz/mW}$, which is also a record among all of the passively HML fiber lasers.
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http://dx.doi.org/10.1364/OL.425898DOI Listing
June 2021

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases.

J Ethnopharmacol 2021 Jun 11;274:114018. Epub 2021 Mar 11.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Background And Ethnopharmacological Relevance: Dioscin and diosgenin derived from plants of the genus Dioscoreaceae such as D. nipponica and D. panthaica Prain et Burk. Were utilized as the main active ingredients of traditional herbal medicinal products for coronary heart disease in the former Soviet Union and China since 1960s. A growing number of research showed that dioscin and diosgenin have a wide range of pharmacological activities in heart diseases.

Aim Of The Study: To summarize the evidence of the effectiveness of dioscin and diosgenin in cardiac diseases, and to provide a basis and reference for future research into their clinical applications and drug development in the field of cardiac disease.

Methods: Literatures in this review were searched in PubMed, ScienceDirect, Google Scholar, China National Knowledge Infrastructure (CNKI) and Web of Science. All eligible studies are analyzed and summarized in this review.

Results: The pharmacological activities and therapeutic potentials of dioscin and diosgenin in cardiac diseases are similar, can effectively improve hypertrophic cardiomyopathy, arrhythmia, myocardial I/R injury and cardiotoxicity caused by doxorubicin. But the bioavailability of dioscin and diosgenin may be too low as a result of poor absorption and slow metabolism, which hinders their development and utilization.

Conclusion: Dioscin and diosgenin need further in-depth experimental research, clinical transformation and structural modification or research of new preparations before they can be expected to be developed into new therapeutic drugs in the field of cardiac disease.
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http://dx.doi.org/10.1016/j.jep.2021.114018DOI Listing
June 2021

Long-term cover crops improved soil phosphorus availability in a rain-fed apple orchard.

Chemosphere 2021 Jul 24;275:130093. Epub 2021 Feb 24.

Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China. Electronic address:

The objective of this present study was to understand the distribution patterns of various forms of soil phosphorus (P) and the biotic and abiotic factors affecting the soil P fractions under long-term cover crops. Here, we investigated the characteristics of soil P forms, community structure of P-solubilizing bacteria (using 16S rRNA) and the related enzyme activity under clean tillage (CT), 14 years of white clover (WC, Trifolium repens L.) and orchard grass (OG, Dactylis glomerata L.) cover crops in a rain-fed apple orchard on the Weibei Loess Plateau, China. Relative to CT treatment, long-term cover crops enhanced the bioavailability of soil P by increasing the contents of total phosphorus (TP), microbial phosphorus (MBP), organic phosphorus (Po) and certain forms of inorganic phosphorus (e.g. Al-P, Ca-P, Ca-P and Fe-P) in the surface soil, in addition, WC treatment also increase the available P (AP) contents in the topsoil. A redundant analysis (RDA) showed that soil organic matter (SOM), NH-N and pH were the key environmental factors affecting the morphological changes of soil P. In addition, the effects of long-term cover crops on soil P forms were mainly concentrated in the topsoil, and the WC treatment had a greater impact on soil P composition than the OG treatment. Interestingly, long-term cover crops effectively increased the abundances of P-solubilizing bacteria, such as Streptomyces, Sphingomonas, Nocardioides and Haliangium, and enhanced the alkaline phosphatase (ALP) activity. Overall, long-term cover crops were an effective strategy to activate soil P as they improve the soil environment.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130093DOI Listing
July 2021

The Impact of Dementia on the Clinical Outcome of COVID-19: A Systematic Review and Meta-Analysis.

J Alzheimers Dis 2020 ;78(4):1775-1782

Department of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: The emergence of the coronavirus disease 2019 (COVID-19) has brought large challenges to dementia patients. We reviewed the existing literature on COVID-19 to assess the incidence and mortality of dementia comorbidities in COVID-19 patients.

Objective: To investigate the impact of pre-existing dementia comorbidities on COVID-19.

Methods: We searched the PubMed, Embase, and Web of Science databases for patients with preexisting dementia who were diagnosed with COVID-19. The statistical data on the prevalence and mortality of dementia comorbidities were examined. A fixed-or random-effect model was used to calculate the overall pooled risk estimates. Forest plots were generated to show the summarized results.

Results: A total of 265 articles were retrieved from the three databases. After removing duplicates and performing two screenings, 10 articles were selected for meta-analysis, including 119,218 participants. Overall, the meta-analysis of the 10 studies showed that the incidence of dementia in COVID-19 patients was (R: 9%, [95% CI: 6% to 13%]). Moreover, the meta-analysis of 9 studies showed that the mortality rate of individuals with dementia after being infected with COVID-19 was higher than that of individuals with no dementia (OR: 5.17 [95% CI: 2.31 to 11.59]). Substantial heterogeneity was observed in this meta-analysis. Significant publication bias was also found.

Conclusion: Emerging literature shows that dementia comorbidities are a high risk factor for the prevalence and mortality of COVID-19. Our results should have an impact on preventive interventions and encourage more targeted approaches to prioritize older people with specific risk factors, such as dementia.
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http://dx.doi.org/10.3233/JAD-201016DOI Listing
December 2020

Evolution and Driving Mechanism of Ecological Security Pattern: A Case Study of Yangtze River Urban Agglomeration.

Integr Environ Assess Manag 2021 May 27;17(3):573-583. Epub 2020 Nov 27.

School of Management Science and Engineering, Nanjing University of Information Science & Technology, Nanjing, China.

Urbanization adversely affects the ecological environment and reduces the quality of life in China. In view of the current situation, this study aims to determine the dynamics of the ecological security pattern of urban agglomerations using the Yangtze River urban agglomeration (YRUA) as a case study. We used the pressure-state-response (PSR) framework to establish an ecological security assessment system, combined with the technique for order of preference by similarity to an ideal solution (TOPSIS) method and gray correlation method, to estimate a comprehensive ecological security index, and we analyzed its evolution trends and driving mechanisms. The results indicated that the distribution of the regional ecological security level had a linked effect and that industrial pollutants posed the greatest threat to ecological security. Moreover, the main factors affecting the YRUA were urbanization, ecopathology, economic development, population pressure, land pressure, and water resource pressure. For the protection of ecological security, it is necessary to establish an ecological security governance mechanism. Moreover, the study stresses changing the traditional sewage discharge model and establishing an ecologically safe market system. Integr Environ Assess Manag 2021;17:573-583. © 2020 SETAC.
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http://dx.doi.org/10.1002/ieam.4358DOI Listing
May 2021

Clinical Efficacy and Safety of Eight Traditional Chinese Medicine Combined with Entecavir in the Treatment of Chronic Hepatitis B Liver Fibrosis in Adults: A Network Meta-Analysis.

Evid Based Complement Alternat Med 2020 30;2020:7603410. Epub 2020 Sep 30.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Background: Traditional Chinese medicine (TCM) is used as an adjuvant drug for the treatment of chronic hepatitis B liver fibrosis and is used frequently. We still do not know which TCM has the best curative effect as an adjuvant drug. Therefore, we decided to use network meta-analysis to solve this problem.

Methods: We used the RevMan software (5.3) and Stata software (13.0) to achieve this network meta-analysis (NMA). The primary outcomes of this study were HA, LN, PCIII, and IV-C; the secondary outcomes of this study were AST, ALT, and HBV-DNA negative conversion rate, and the Cochrane risk-of-bias tool was used to assess the quality of the included studies. For all outcomes, the scissors funnel plot, Egger test, and Begg test were used to detect publication bias, and sensitivity analysis was used to investigate the stability of the results. And the meta-regression was used to explore the source of heterogeneity.

Results: A total of 34 articles were included in this study. The study involved a total of 3199 patients, of which 1578 were assigned to the control group and 1621 patients were assigned to the experimental group. The number of men and women is roughly equal, and the average age is about 43 years old. In addition, nine treatment strategies were involved in this study. The combination of TCM and entecavir can significantly improve the patients' HA, LN, PCIII, IV-C, AST, ALT, and HBV-DNA negative conversion rates. The comprehensive evaluation results showed that FHC combined with entecavir has more advantages than other treatment strategies.

Conclusion: For improving the HBV-DNA negative conversion rates, adding TCM to the therapeutic strategies does not seem to show absolute superiority. Finally, FHC combined with entecavir is the best therapeutic strategy.
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http://dx.doi.org/10.1155/2020/7603410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545414PMC
September 2020

The Effects of the Dynamic Thermophysical Properties of Clothing and the Walking Speed Input Parameter on the Heat Strain of a Human Body Predicted by the PHS Model.

Int J Environ Res Public Health 2020 09 5;17(18). Epub 2020 Sep 5.

College of Fashion and Design, Donghua University, Shanghai 200051, China.

The prediction accuracy of the Predicted Heat Strain (PHS) model is affected by the correction approaches of static thermophysical properties of clothing considering the pumping effects of wind and body movement. In this study, a comparison of different correction algorithms for three types of clothing and their influence on the heat strain predicted by the PHS model was carried out with experimental data obtained from the literature. Results show that the dynamic insulation values calculated by ISO 9920 corrections are larger than those obtained by ISO 7933 when the static insulation values are higher than 0.4 clo, but when the static values are lower than 0.4 clo, it varies contrarily. The dynamic evaporative resistance values calculated with ISO 9920 equations are larger than those with ISO 7933. The prediction accuracy of the PHS model with ISO 9920 corrections and the addition of the walking speed input parameter can be improved for normal clothing (NC) in a hot environment and high clothing insulation. For specialized, insulating, cold weather clothing (SC), ISO 7933 corrections with an added walking speed input parameter to the PHS model have a good prediction precision.
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http://dx.doi.org/10.3390/ijerph17186475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558563PMC
September 2020

NiMOF-derived oxygen vacancy rich NiO with excellent capacitance and ORR/OER activities as a cathode material for Zn-based hybrid batteries.

Dalton Trans 2020 Sep;49(35):12441-12449

Department of Chemistry, College of Science, Northeastern University, Shenyang, 110819, P.R. China.

An Ni-Zn battery is a distinguished member in the family of closed Zn-based batteries due to its ideal power density and voltage. However, when it is employed as a power supply for electric vehicles, its defects in terms of specific capacitance and energy density become obvious. Herein, to resolve this problem, a hybrid battery system was created through a combination of Ni-Zn and Zn-air batteries at the cell level. In a hybrid battery system, oxygen vacancy rich NiO with S,N co-modified mesoporous carbon as a matrix was used as the cathode material. This cathode material showed a high specific capacitance of 202.1 mA h g-1 at 1.0 A g-1. When the current density reduces to 20 A g-1, this value decreases to 130.2 mA h g-1, which implies that 64.4% of specific capacitance was retained. It also exhibits excellent OER and ORR activities. For the hybrid battery system, when the discharge process was carried out at 1 mA cm-2, there were two voltage plateaus at 1.72 and 1.12 V, which originated from Ni-Zn and Zn-air, respectively. In this case, its specific capacitance and energy density reaches 800.3 mA h g-1 and 961 W h kg-1, respectively. The hybrid battery also possesses perfect stability during multi-cycle charge-discharge tests. The construction of this hybrid battery system develops a new road to prepare a power supply device with high performance.
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http://dx.doi.org/10.1039/d0dt01153cDOI Listing
September 2020

The relationship between semen factors and unexplained recurrent spontaneous abortion.

Clin Chim Acta 2020 Nov 20;510:605-612. Epub 2020 Aug 20.

Reproductive Medical Center of Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China. Electronic address:

Background: The male factor may contribute to unexplained recurrent spontaneous abortion (URSA). The relationship between semen factors and URSA is largely unknown. The analysis of metabolomics which is broadly acknowledged as the omics closest to the phenotype is suitable for providing assistance in the semen parameters analysis.

Methods: We conducted a study including couples with URSA and controls which was next combined with a meta-analysis, and finally the study included 2352 subjects on semen parameters and URSA. Metabolomics analysis was conducted to detect semen metabolic factors related to URSA in total of 106 samples including seminal plasma and sperm cells.

Results: The URSA group had significantly lower total sperm count, sperm concentration, motility and normal morphology percentage. Meta-analysis next showed consistent findings. Metabolomics revealed that 4 metabolites and one pathway and 8 metabolites and one pathway were significantly associated with URSA in sperm and seminal plasma, respectively. The combination of ascorbic acid and guanine in seminal plasma and hexadecanedioic acid and pyroglutamic acid in sperm showed ability for URSA prediction.

Conclusion: We provided novel insights into semen indices in relation to URSA. Lower sperm number and quality might increase the risk of URSA, and oxidative stress and hormone metabolism in sperm as well as nucleic acid synthesis and oxidative stress in seminal plasma were related to URSA.
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http://dx.doi.org/10.1016/j.cca.2020.08.022DOI Listing
November 2020

Acidity and Glutathione Dual-Responsive Polydopamine-Coated Organic-Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery.

ChemMedChem 2020 Oct 10;15(20):1940-1946. Epub 2020 Sep 10.

College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.

Controversial biodegradability and nonspecific pre-drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic-inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultaneously achieve enhanced biodegradability and controllable drug release. The morphology and chemical structure of the nanoparticles were characterized by TEM, N adsorption-desorption isotherms, TEM-mapping and XPS. Moreover, the release behavior of nanoparticles under various pH conditions and the degradation behavior in the presence of GSH were evaluated. With effective controlled release, [email protected] were shown to significantly inhibit cancer cell proliferation and achieve antitumor effects in vivo through dual-response release in the tumor microenvironment. Overall, this nanoplatform has significant potential to achieve tumor microenvironment-responsive degradation and release to enhance tumor accumulation, which is very promising for cancer treatment.
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http://dx.doi.org/10.1002/cmdc.202000263DOI Listing
October 2020

Intracavity birefringence-controlled GHz-tuning range passively harmonic mode-locked fiber laser based on NPR.

Appl Opt 2020 Aug;59(22):6724-6728

We experimentally demonstrate a harmonic-order controllable L-band Er-doped passively mode-locked fiber laser based on nonlinear polarization rotation (NPR). Distinct from all previous reports, we find that the intracavity birefringence is able to control the harmonic order of a passively mode-locked fiber laser. Experimentally, under a constant pump power of 704 mW, the harmonic order can be tuned from 113th to 39th monotonically by adjusting the polarization controller orientation only. The corresponding repetition rate changes from 2.21 to 0.77 GHz simultaneously. Remarkably, the super-mode suppression ratio of each harmonic order we observed is higher than 29 dB with a maximum of 36.5 dB. Simulated transmission spectra of NPR prove that the changed transmission plays an important role in controlling the harmonic order.
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http://dx.doi.org/10.1364/AO.398960DOI Listing
August 2020

Determination of Ferulic Acid in by Temperature-Controlled Hydrophobic Ionic Liquids-Based Ultrasound/Heating-Assisted Extraction Coupled with High Performance Liquid Chromatography.

Molecules 2020 Jul 24;25(15). Epub 2020 Jul 24.

Department of Chemistry, Zhejiang University, Hangzhou 310028, China.

Hydrophilic ionic liquids are often used to extract the active ingredients of medicinal plants, while hydrophobic ionic liquids are rarely used to directly extract solid samples. In this paper, a simple, novel and efficient temperature-controlled hydrophobic ionic liquids-based ultrasound/heating-assisted extraction (TC-ILs-UHAE) procedure coupled with high-performance liquid chromatography (HPLC) was developed and applied to the determination of ferulic acid (FA) in Chinese herbal medicine . During the extraction procedure, hydrophobic ionic liquids (ILs) were dispersed into water to form cloudy solution (fine droplets) with the aid of ultrasound and heating simultaneous. After extraction, phase separation was easily achieved by centrifuging at 0 °C. Among all ILs used, 1-butyl-3-methylimidazolium bis(trifluoromethanesulphonyl)imide ([Cmim]NTf) exhibited the highest extraction ability and the possible extraction mechanism was discussed. Additionally, the synergistic effect of heating and ultrasound on the extraction efficiency was investigated. Under the optimized conditions, a good linearity was observed with correlation coefficient () of 0.9995. The limit of detection of FA (LOD, / = 3) was 9.6 µg/L and the spiked recoveries of FA for real samples were in the range of 91.67 to 102.00% with relative standard deviation (RSD) lower than 3.87%. Compared with the traditional extraction methods, the proposed method gave the highest yield of FA and had the shortest extraction time. Therefore, this method is a potential simple, green and highly efficient technique and expected to be applied to the extraction of other bioactive ingredients in medicinal plants.
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http://dx.doi.org/10.3390/molecules25153356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436256PMC
July 2020

Mulching practices alter soil microbial functional diversity and benefit to soil quality in orchards on the Loess Plateau.

J Environ Manage 2020 Oct 23;271:110985. Epub 2020 Jun 23.

Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, Shaanxi, China. Electronic address:

To improve our understanding about the responses of microbial functional diversity to different mulching practices, this study used a metagenomic approach to reveal soil microbial functional specificity under four tillage regimes: conventional tillage (CT), organic mulch practices with ryegrass (Lolium perenne L.) intercropping cover (RE) and cornstalk mulch (CS), and inorganic mulching with black ground fabric (BF) in a 7-year field experiment in an apple orchard of the Loess Plateau in China. Enzyme activity and soil physicochemical properties were measured. A redundancy analysis showed that the RE and CS treatments had positive effects on soil nutrient and enzyme activity compared to that of the BF and CT treatments. The CS and RE treatments increased β-glucosidase, cellobiohydrolase, and β-xylosidase activities. In addition, the CS treatment significantly enhanced the β-N-acetylglucosaminidase and urease activities compared to that under CT treatment. However, the activity of these enzyme was reduced in the BF treatment compared with that of the CT treatment. The results also indicated that the enzymes activities were not completely consistent with the changing trends of the genes encoding these enzymes. In addition, the RE and CS treatments also increased the abundance of genes encoding carbohydrate enzymes. It is interesting that the RE and CS treatments had more pathway genes associated with the carbon cycle, nitrogen cycle, and amino acid metabolism compared with the BF treatment. Remarkably, RE and CS treatments effectively increased the abundance of carbon fixation gene cbbL compared to CT treatment. In summary, organic mulching practices increased the soil microbiological functional diversity related to the carbon and nitrogen cycle, while inorganic mulching practice reduced them. This study enhanced our understanding of how mulching practices may alter soil microbial functional diversity and benefit soil quality.
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http://dx.doi.org/10.1016/j.jenvman.2020.110985DOI Listing
October 2020

Adaptive changes induced by noble-metal nanostructures and .

Theranostics 2020 27;10(13):5649-5670. Epub 2020 Apr 27.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.

The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues and organs, requiring careful studies towards their biological effects and . Upon NMNs exposure, tissues and cells may undergo a series of adaptive changes both in morphology and function. At the cellular level, the accumulation of NMNs in various subcellular organelles including lysosomes, endoplasmic reticulum, Golgi apparatus, mitochondria, and nucleus may interfere with their functions, causing changes in a variety of cellular functions, such as digestion, protein synthesis and secretion, energy metabolism, mitochondrial respiration, and proliferation. In animals, retention of NMNs in metabolic-, respiratory-, immune-related, and other organs can trigger significant physiological and pathological changes to these organs and influence their functions. Exploring how NMNs interact with tissues and cells and the underlying mechanisms are of vital importance for their future applications. Here, we illustrate the characteristics of NMNs-induced adaptive changes both and . Potential strategies in the design of NMNs are also discussed to take advantage of beneficial adaptive changes and avoid unfavorable changes for the proper implementation of these nanoplatforms.
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http://dx.doi.org/10.7150/thno.42569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254997PMC
April 2020

Point-prevalence surveys of hospital-acquired infections in a Chinese cancer hospital: From 2014 to 2018.

J Infect Public Health 2020 Dec 9;13(12):1981-1987. Epub 2020 Apr 9.

Department of Hospital Infection Prevention and Control, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, China. Electronic address:

Background: Both hospital-acquired infection (HAI) and cancer represents major health concerns worldwide, but there is a paucity of data describing HAI in Chinese cancer patients. The objective of this study is to demonstrate the prevalence, causative agents, antimicrobial use and risk factors for HAI in a cancer hospital in Southwestern China.

Methods: We use the criteria of the Ministry of Health of the People's Republic of China to define hospital-acquired infections. One-day cross-sectional surveys were annually conducted from 2014 to 2018. Trained staff collected hospital-acquired infections, antimicrobial use and clinical characteristics data of inpatients. Multivariate logistic regression was used to determine the potential risk factors associated with HAIs.

Results: Of the 6717 patients surveyed, there were 140 patients (2.1%, 95% confidence interval, 1.7-2.4%) with 144 distinct HAIs. Lower respiratory tract infections (47, 32.6%) and surgical-site infections (29, 20.1%) were the most common HAIs. Escherichia coli was the most common pathogen (29.6%). Risk factors for HAI included younger age (<18 years) or older age (>65 years), hospitalization in the intensive care unit, presence of central catheter and undergoing surgery in the previous 30 days. The overall prevalence of patients receiving antimicrobial agents was 15.2%.

Conclusion: To control hospital-acquired infections in cancer patients, surveillance and prevention strategies to infections associated with central catheters or related to surgery should be augmented.
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http://dx.doi.org/10.1016/j.jiph.2020.03.003DOI Listing
December 2020

Wavelength-tunable bidirectional passively Q-switched Er-doped fiber laser incorporating a single-walled carbon nanotube and tunable bandpass filter.

Appl Opt 2020 Mar;59(9):2709-2714

We demonstrated a continuously wavelength-tunable bidirectional passively $ Q $Q-switched fiber laser based on a single-walled carbon nanotube saturable absorber and a bandpass filter (BPF). By tuning the commercial BPF, the $ Q $Q-switched pulse can be obtained in the same cavity at the same pump power in clockwise (CW) and counter-clockwise (CCW) directions. The central wavelength can be continuously tuned from 1520.88 to 1568.56 nm in the CW direction, and from 1520.96 to 1568.64 nm in the CCW direction. A wide tuning range of 48 nm is achieved for two directions in the passively $ Q $Q-switched fiber laser. During the tuning process of the fiber laser, the output pulses with the same central lasing wavelength can be obtained in both oscillation directions owing to the BPF. By increasing the pump power from 130 to 350 mW, the cavity delivers a $ Q $Q-switched pulse with the central wavelength of 1560 nm whose repetition rate changes from 9.64 to 59.18 kHz for the CW direction. In the CCW direction, the repetition rate of the $ Q $Q-switched pulse changes from 10.26 to 61.03 kHz. To the best of our knowledge, it is the first time that continuous wavelength-tunable passively $ Q $Q-switched pulses have been achieved in a bidirectional erbium-doped fiber laser.
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http://dx.doi.org/10.1364/AO.387843DOI Listing
March 2020

Isolation of a novel strain Aspergillus niger WH-2 for production of L(+)-tartaric acid under acidic condition.

Biotechnol Lett 2020 Apr 18;42(4):605-612. Epub 2020 Jan 18.

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023, China.

Objectives: To isolate a novel cis-epoxysuccinate hydrolase (CESH)-producing fungus for production of L( +)-tartaric acid, before this, all strains were selected from bacteria.

Results: A CESH-producing fungus was first isolated from soil and identified as Aspergillus niger WH-2 based on its morphological properties and ITS sequence. The maximum activity of hyphaball and fermentation supernatants was 1278 ± 64 U/g and 5.6 ± 0.3 U/mL, respectively, in a 5 L fermenter based on the conditions optimized on the flask. Almost 70% of CESH was present in hyphaball, which maintained 40% residual activity at pH 4.0 and showed a good acid stability (pH 3.0-10.0), high conversion rate (> 98%), and enantioselectivity (EE > 99.6%). However, the reported CESHs from bacteria can't be catalyzed under acidic conditions.

Conclusions: The Aspergillus niger WH-2 was the first reported CESH-producing fungus, which could biosynthesize L ( +)-tartaric acid under acidic conditions and provide an alternative catalyst and process.
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http://dx.doi.org/10.1007/s10529-020-02799-zDOI Listing
April 2020

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology.

Mol Ther Nucleic Acids 2020 Mar 17;19:581-601. Epub 2019 Dec 17.

Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P.R. China. Electronic address:

Due to a series of systemic and intracellular obstacles in nucleic acid (NA) therapy, including fast degradation in blood, renal clearance, poor cellular uptake, and inefficient endosomal escape, NAs may need delivery methods to transport to the cell nucleus or cytosol to be effective. Advanced nanoscale biotechnology-associated strategies, such as controlling the particle size, charge, drug loading, response to environmental signals, or other physical/chemical properties of delivery carriers, have provided great help for the in vivo and in vitro delivery of NA therapeutics. In this review, we introduce the characteristics of different NA modalities and illustrate how advanced nanoscale biotechnology assists NA therapy. The specific features and challenges of various nanocarriers in clinical and preclinical studies are summarized and discussed. With the help of advanced nanoscale biotechnology, some of the major barriers to the development of NA therapy will eventually be overcome in the near future.
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http://dx.doi.org/10.1016/j.omtn.2019.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957827PMC
March 2020

Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis.

Medicine (Baltimore) 2020 Jan;99(2):e18550

Department of Breast Surgery, West China Hospital/West China School of Medicine.

Background: Adjuvant endocrine therapy is a vital portion of postoperative comprehensive treatment for breast cancer patients. In recent years, studies have shown that endocrine therapy has a certain impact on the serum lipids of breast cancer patients, and the changes of lipid profiles may bring a series of problems. However, very few studies focus on this issue to date. The results of these studies are inconsistent, and the influence of different adjuvant endocrine modalities on lipid profiles still remains controversial. In order to better explore this issue, we conduct this network meta-analysis.

Method: The protocol followed preferred reporting items for systematic reviews and meta-analyses protocols. Three main databases (PubMed, Embase, and the Cochrane Library) will be searched systematically for eligible randomized controlled trials without language restriction. In addition, a manual search of the references of relevant published studies will also be considered. Two reviewers will conduct studies selection, data extraction, and risk of bias assessment independently. The primary outcome is the variation of biochemical parameters - the serum lipid profiles (cholesterol, triglyceride, high-density lipoprotein, low low-density lipoprotein).

Results: The results will provide useful information about the side effects of different adjuvant endocrine drugs on lipid profiles in postoperative breast cancer patients (estrogen receptor-positive and/or progesterone receptor-positive).

Conclusion: The findings of this study will be published in a peer-reviewed journal.

Prospero Registration Number: CRD42019129850.
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http://dx.doi.org/10.1097/MD.0000000000018550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959941PMC
January 2020

The central nucleus of the amygdala lesion attenuates orthodontic pain during experimental tooth movement in rats.

Brain Behav 2020 01 20;10(1):e01506. Epub 2019 Dec 20.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi'an Jiaotong University College of Stomatology, Xi'an, Shaanxi, China.

Introduction: Orthodontic pain is the most common adverse side effect reported in the context of tooth movement. Given its central role in processing pain and negative emotion, the central nucleus of the amygdala (CeA) is thought to be a key site involved in orthodontic pain sensation.

Methods: In the present study, we therefore explored whether the CeA is involved in contributing to orthodontic pain in a rat model of tooth movement. For this study, we utilized adult male rats with bilateral sham or electrolytic CeA lesions (400 μA; 25 s), and then we analyzed face grooming behavior as a measure of pain sensation.

Results: Through this approach, we found that there were time- and force-dependent factors influencing pain levels in these rats. We further found that bilateral CeA lesions markedly reduced tooth movement-induced orofacial pain and that unilateral CeA lesions did so to a lesser extent.

Conclusions: As such, these results suggest the CeA is a key area of orthodontic pain, with the results of this study highlighting potential avenues for achieving pain relief in those suffering from orthodontic pain.
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http://dx.doi.org/10.1002/brb3.1506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955828PMC
January 2020

Predictive value of integrin α7 for acute myeloid leukemia risk and its correlation with prognosis in acute myeloid leukemia patients.

J Clin Lab Anal 2020 Apr 19;34(4):e23151. Epub 2019 Dec 19.

Department of Hematology, Guizhou Provincial People's Hospital, Guiyang, China.

Background: This study aimed to explore the predictive value of integrin α7 (ITGA7) for acute myeloid leukemia (AML) risk and subsequently investigate its correlation with risk stratification and prognosis in AML patients.

Methods: Bone marrow samples were obtained from 196 de novo AML patients prior to initiation of treatment and from 50 subjects underwent bone marrow donation or bone marrow biopsy for non-hematologic malignant disease (as controls). ITGA7 mRNA and protein expressions were detected by real-time quantitative polymerase chain reaction and Western blot assays, respectively. In AML patients, the risk stratification was assessed, and complete remission (CR), event-free survival (EFS), and overall survival (OS) were evaluated.

Results: Both ITGA7 mRNA and protein expressions were increased in AML patients compared with controls, and their expressions were correlated with poorer risk stratification. For prognosis, ITGA7 mRNA expression and protein expression were declined in CR patients compared to non-CR patients. Meanwhile, both EFS and OS were shorter in ITGA7 mRNA high expression patients compared to ITGA7 mRNA low expression patients, as well as ITGA7 protein high expression patients compared to ITGA7 protein low expression patients.

Conclusion: Integrin α7 might serve as a potential biomarker for predicting increased AML risk and worse prognosis in AML patients.
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http://dx.doi.org/10.1002/jcla.23151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171313PMC
April 2020

Evaluation of Turning-Sized Gold Nanoparticles on Cellular Adhesion by Golgi Disruption and .

Nano Lett 2019 12 20;19(12):8476-8487. Epub 2019 Nov 20.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology of China , Beijing 100190 , P.R. China.

In contrast to the booming production and application of nanomaterials, research on the toxicological impacts and possible hazards of nanoparticles to tissues and organs is still in its infancy. Golgi apparatus is one of the most important organelles in cells and plays a key role in intracellular protein processing. The structural integrity of Golgi is vital for its normal function, and Golgi disturbance could result in a wide range of diseases and disorders. In this study, for the first time we found gold nanoparticles (Au NPs) induced size-dependent cytoplasmic calcium increase and Golgi fragmentation, which hampers normal Golgi functions, leads to abnormal protein processing, and causes cellular adhesion decrease, while cell viability was not significantly compromised. Additionally, early renal pathological changes were induced . This work is significant to nanoparticle research because it illustrates the important role of size on Au NP-induced changes in Golgi morphology and their consequences and , which has important implications for the biological applications of nanomaterials.
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http://dx.doi.org/10.1021/acs.nanolett.9b02826DOI Listing
December 2019

All-fiber passively mode-locked ultrafast laser based on a femtosecond-laser-inscribed in-fiber Brewster device.

Opt Lett 2019 Nov;44(21):5177-5180

We report on an in-fiber Brewster device with a 45° tilted fiber grating (TFG) directly written by a plane-by-plane femtosecond laser inscription method. Up to 10 dB polarization-dependent loss was achieved, proving effective polarizing functionality. Furthermore, we employ it as an in-line polarizer to successfully mode lock a fiber laser through the nonlinear polarization rotation technique. A stable soliton pulse train has been generated at 1563.64 nm with a pulse width of 624 fs and pulse energy of 0.42 nJ. With proper polarization adjustment, the laser also can operate in a noise-like regime. The parameters of this kind of 45°-TFG can be flexibly customized owing to the high flexibility and controllability of the femtosecond laser-inscription approach. In particular, such in-fiber polarizing devices inscribed by femtosecond laser inscription without removing the fiber coating are extremely robust for fiber lasers working at a broad wavelength region including the mid-infrared.
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http://dx.doi.org/10.1364/OL.44.005177DOI Listing
November 2019

Purification, characterization, and gene cloning of two laccase isoenzymes (Lac1 and Lac2) from Trametes hirsuta MX2 and their potential in dye decolorization.

Mol Biol Rep 2020 Jan 29;47(1):477-488. Epub 2019 Oct 29.

The Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province, School of Agricultural and Food Science, Zhejiang A&F University, Hangzhou, 311300, China.

In this study, two laccase isoenzymes (Lac1 and Lac2) from the culture supernatant of Trametes hirsuta MX2 were purified, and the genes (Lac1 and Lac2) coding the isoenzymes were cloned. Both Lac1 and Lac2 contained an open reading frame of 1563 bp with an identity of 79%. The two isoenzymes showed significant biochemical differences. The maximal activities of Lac1 and Lac2 were at pH 2.5 with 2-2'-azino-di-(3-ethylbenzthiazoline sulfonic acid) (ABTS), and the optimal temperatures for the activities of Lac1 and Lac2 were 60 and 50 °C, respectively. Lac1 exhibited excellent resistance to acidic conditions and retained 62.17% of its initial activity at pH 2.5 after a 72-h incubation. Lac2 was more thermostable than Lac1 with half-lives (t) of 9.58 and 3.12 h at 50 and 60 °C, respectively; the t of Lac1 were only 4.19 and 0.88 h, respectively. Both Lac1 and Lac2 isoenzymes have a strong tolerance to Mg, Mn, Cu, and EDTA (50 mM). At a low concentration of 0.05 U mL, the enzymes could decolorize towards Remazol Brilliant Blue R, Acid Red 1, Crystal Violet, and Neutral Red in the presence of ABTS. These unusual properties demonstrated that the two laccases have strong potential for specific industrial applications.
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http://dx.doi.org/10.1007/s11033-019-05154-2DOI Listing
January 2020

Effects of intercropping mulch on the content and composition of soil dissolved organic matter in apple orchard on the loess plateau.

J Environ Manage 2019 Nov 9;250:109531. Epub 2019 Sep 9.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, PR China; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling, Shaanxi, 712100, PR China. Electronic address:

Dissolved organic matter (DOM) is an important parameter that reflects soil fertility and quality. In this study, the effects of intercropping perennial ryegrass and straw mulch on the content, composition and spectral characteristics of soil DOM in orchards in arid and semi-arid areas were investigated by three-dimensional fluorescence excitation-emission matrix (EEM) combined with parallel factor analysis (PARAFAC). Three treatments were applied in a 6-year-old apple orchard on the Loess Plateau: (1) clean tillage (CT); (2) intercropping perennial ryegrass mulch (RE); (3) intercropping straw mulch (CS). Soil samples (0-10, 10-20, 20-40, 40-60, 60-80, 80-100 cm) were collected from different treatments. The total soil organic carbon (SOC) and dissolved organic carbon (DOC) content were ranked as CS> RE> CT, and decreased with soil depth. In addition, the vertical distribution of DOC with different soil depth was caused by organic matter input but not leaching. Three humic-like components and two protein-like components were identified by EEM-PARAFAC. Fluorescence spectra showed that humic-like compounds were the dominant fractions in soil DOM in the CS treatment. Fluorescence Index (FI) indicated that the proportion of plant residues and soil organic matter derived DOM ranked as CT> RE> CS and gradually decreased with soil depth. Our results highlight the key role of orchard intercropping mulch in improving the content and compositions of soil DOM through different forms of organic inputs and provide new theoretical support for the evaluation of soil fertility in orchards.
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http://dx.doi.org/10.1016/j.jenvman.2019.109531DOI Listing
November 2019

23 MHz widely wavelength-tunable L-band dissipative soliton from an all-fiber Er-doped laser.

Opt Express 2019 Jul;27(14):20028-20036

Via careful choice of Er-doped fiber length in the cavity, a widely wavelength-tunable L-band dissipative soliton all-fiber Er-doped laser incorporating a L-band optimized polarizing fiber grating device is experimentally demonstrated. The laser delivers 15.38 ps dissipative soliton pulses centered at 1597.34 nm with 3 dB bandwidth of 34.6 nm under 622 mW pump power. The pulse repetition rate is 23 MHz. After using single mode fiber at external cavity, the pulse duration is compressed to 772 fs. With nonlinear polarization rotation-based intracavity comb filter, the central wavelength of the generated dissipative soliton can be tuned from 1567 nm to 1606 nm with a spectral tuning range of 39 nm, which, to the best of our knowledge, is the widest tuning range yet reported for a dissipative soliton fiber laser working in communication band.
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http://dx.doi.org/10.1364/OE.27.020028DOI Listing
July 2019

Efficacy of Origanum vulgare essential oil and carvacrol against the housefly, Musca domestica L. (Diptera: Muscidae).

Environ Sci Pollut Res Int 2019 Aug 17;26(23):23824-23831. Epub 2019 Jun 17.

School of Agricultural and Food Science, Zhejiang A&F University, Hangzhou, 311300, People's Republic of China.

The toxicity of Origanum vulgare essential oil to the housefly Musca domestica L. was evaluated. The major constituents of the O. vulgare essential oil by gas chromatographic mass spectrometry (GC-MS) analysis were carvacrol (58.13%), p-cymene (17.85%), thymol (8.15%), γ-terpinene (4.96%), and linalool (3.69%). Toxicity of O. vulgare essential oil against larvae and pupae was evaluated using fumigation and contact assays. The contact toxicity (LC) of O. vulgare essential oil and carvacrol for larvae was 0.23 and 0.03 μL/cm, respectively. The fumigation toxicity (LC) of O. vulgare essential oil and carvacrol for larvae was 9.52 and 2.78 μL/L, respectively. Pupal toxicity was evaluated by percentage inhibition rate (PIR). PIR of O. vulgare essential oil at 0.25 μL/cm was 90.9% for the contact assay and 100% at 20 μL/L for the fumigation assay. PIR of carvacrol was 29.5% (0.025 μL/cm) and 81.8% (1.25 μL/L) for the contact toxicity and fumigation assay, respectively. O. vulgare essential oil and carvacrol have significant toxicity to the housefly and are potential insecticides for housefly control.
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http://dx.doi.org/10.1007/s11356-019-05671-4DOI Listing
August 2019