Publications by authors named "Qiang Zhao"

1,107 Publications

  • Page 1 of 1

Structures of the human cholecystokinin receptors bound to agonists and antagonists.

Nat Chem Biol 2021 Sep 23. Epub 2021 Sep 23.

State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Cholecystokinin receptors, CCKR and CCKR, are important neurointestinal peptide hormone receptors and play a vital role in food intake and appetite regulation. Here, we report three crystal structures of the human CCKR in complex with different ligands, including one peptide agonist and two small-molecule antagonists, as well as two cryo-electron microscopy structures of CCKR-gastrin in complex with G and G, respectively. These structures reveal the recognition pattern of different ligand types and the molecular basis of peptide selectivity in the cholecystokinin receptor family. By comparing receptor structures in different conformational states, a stepwise activation process of cholecystokinin receptors is proposed. Combined with pharmacological data, our results provide atomic details for differential ligand recognition and receptor activation mechanisms. These insights will facilitate the discovery of potential therapeutics targeting cholecystokinin receptors.
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http://dx.doi.org/10.1038/s41589-021-00866-8DOI Listing
September 2021

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor.

Nat Chem Biol 2021 Sep 23. Epub 2021 Sep 23.

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Cholecystokinin A receptor (CCKR) belongs to family A G-protein-coupled receptors and regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive drug target for gastrointestinal and metabolic diseases. One distinguishing feature of CCKR is its ability to interact with a sulfated ligand and to couple with divergent G-protein subtypes, including G, G and G. However, the basis for G-protein coupling promiscuity and ligand recognition by CCKR remains unknown. Here, we present three cryo-electron microscopy structures of sulfated CCK-8-activated CCKR in complex with G, G and G heterotrimers, respectively. CCKR presents a similar conformation in the three structures, whereas conformational differences in the 'wavy hook' of the Gα subunits and ICL3 of the receptor serve as determinants in G-protein coupling selectivity. Our findings provide a framework for understanding G-protein coupling promiscuity by CCKR and uncover the mechanism of receptor recognition by sulfated CCK-8.
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http://dx.doi.org/10.1038/s41589-021-00841-3DOI Listing
September 2021

EZH2 identifies the precursors of human natural killer cells with trained immunity.

Cancer Biol Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Immunology and Biotherapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation. However, the human NK cells responsible for the generation and maintenance of trained immunity are largely unknown. We hypothesized that heterogeneous human NK cells would respond differentially to stimulation with a combination of IL-12, IL-15, and IL-18, and that an NK cell subset might exist that is mainly responsible for the induction of trained immunity. On the basis of our hypothesis, we aimed to identify the subset from which cytokine-trained human NK cells originate and to explore possible regulatory targets for drug intervention.

Methods: Flow cytometry assays were performed to analyze the functions of cytokine-trained NK cells and examine cell division and protein expression in NK cell subsets. Single-cell RNA sequencing (scRNA-seq) plus TotalSeq™ technology was used to track the heterogeneity of NK cells during the induction of trained immunity.

Results: Traditional developmental markers for peripheral NK cells were unable to identify the precursors of human NK cells with trained immunity. Therefore, we used scRNA-seq plus TotalSeq™ technology to track the heterogeneity of NK cells during the induction of trained immunity and identified a unique cluster of CD57NKG2AEZH2IFNGMKI67IL12RIL15RIL18R NK cells. Enrichment and pseudotime trajectory analyses suggested that this cluster of NK cells contained the precursor of trained NK cells. We then used flow cytometry to further investigate the role of EZH2 in trained NK precursors and found that CD57NKG2AEZH2 NK cells had faster cell cycles and an enhanced trained phenotype, and EZH2 inhibition significantly impaired the induction of trained immunity in NK cells. These results suggested that EZH2 is a unique epigenetic marker of precursors of human NK cells with trained immunity.

Conclusions: Our work revealed human NK heterogeneity in the induction of trained immunity, identified the precursor subset for trained NK cells, and demonstrated the critical role of EZH2 in the induction of trained immunity in human NK cells.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0791DOI Listing
September 2021

Synthesis, Structures, and Sorption Properties of Two New Metal-Organic Frameworks Constructed by the Polycarboxylate Ligand Derived from Cyclotriphosphazene.

ACS Omega 2021 Sep 2;6(36):23110-23116. Epub 2021 Sep 2.

School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. China.

Solvothermal reactions of hexakis(4-carboxyphenoxy)cyclotriphospazene (HL1) with copper ions in DMF/HO produced one complex, {[Cu(L1)(OH)(HO)]·guest} (), but with copper ions and auxiliary rigid 4,4-bipyridine (bpy) produced another new complex, namely, {[Cu(L1)(bpy)(HO)]·guest} (). These complexes had been characterized by IR spectroscopy, elemental analysis, and X-ray structural determination. exhibits a 3D anionic structure with the binodal 4,8-connected network with Schläfli symbol {4}{4·6·8}, consisting of Cu clusters and L1 ligands. In contrast, complex possesses a different 3D network with trinodal 3,4,6-c topology with Schläfli symbol {4·6}{4·6·8·10}{6·8·10}. In these two complexes, the semirigid hexacarboxylate ligands adopt distinct conformations to connect metal ions/clusters, which must be ascribed to the addition of the auxiliary rigid ligand in reaction systems. In addition, gas absorption properties of and including CO and N were further investigated.
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http://dx.doi.org/10.1021/acsomega.1c02492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444217PMC
September 2021

Bimetallic Cu-Co-Se nanotube arrays assembled on 3D framework: an efficient bifunctional electrocatalyst for overall water splitting.

ChemSusChem 2021 Sep 21. Epub 2021 Sep 21.

Taiyuan University of Technology, Institue of surface engineering, Yingze West Street 79, 030024, Taiyuan, CHINA.

The highly active bifunctional electrocatalysts for water splitting is of particular importance for the widespread usage of renewable energy, which require synergistic effect of ingenious architecture and intrinsic catalytic activity. Herein, we synthesized a novel Cu-Co-Se nanotube array supported on 3D copper skeleton as high-efficiency bifunctional electrocatalyst for overall water splitting via a facile two-step hydrothermal method. The rational designed CuCo-Se nanotube electrocatalyst exhibits good electrocatalytic performance, with only overpotential of 152 mV to generate 10 mA cm -2 for the HER while a small overpotential of 332 mV to drive a current density of 50 mA cm -2 for the OER process. The as-revealed good electrocatalytic performance is mainly due to the large electrochemical surface areas and electronic coupling synergies triggered by quantities of self-supported bimetallic nanotube architecture. The water-splitting system assembled using Cu-Co-Se nanotube as cathode and anode only needs a cell voltage of 1.65 V to drive current density of 10 mA cm -2 with long durability of 50 h for overall water splitting. Furthermore, the DFT calculation proves that the existence of electron exchange between the neighboring bi-metals as well as the coupling between Cu, Co and Se assembles contribute to the improvement of the water splitting performance. This work provides a general strategy to develop cost-efficient and geometrically-superior bimetallic electrocatalysts toward water splitting for large-scale hydrogen production.
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http://dx.doi.org/10.1002/cssc.202101771DOI Listing
September 2021

Effect of neutrophil-to-lymphocyte ratio on short-term prognosis of elderly patients with hip fracture.

Am J Transl Res 2021 15;13(8):9122-9128. Epub 2021 Aug 15.

Department of Traumatic Orthopedics, Maoming People's Hospital Maoming, Guangdong Province, China.

Objective: To investigate the effect of neutrophil-to-lymphocyte ratio (NLR) on short-term prognosis in elderly patients with hip fracture.

Methods: Altogether, 124 elderly patients with hip fractures who underwent surgery in our hospital were retrospectively studied, and they were divided into survival group (n=98) and death group (n=26) according to their 1-year survival. General data of both groups were collected and compared, and indicators with statistical differences in univariate analysis were further examined by logistic regression analysis. Venous blood samples were drawn from all patients 1 day after the surgery to detect and compare NLR, serum procalcitonin (PCT) and C-reactive protein (CRP) levels between both groups. ROC curve was used to analyze the clinical value of NLR in predicting the prognosis of patients. NLR cutoff value obtained by the ROC curve analysis was adopted to divide the patients into high and low ratio groups, and Kaplan-Meier (K-M) curves were used to assess the survival rate of patients in both groups.

Results: There were significant differences in age, gender, marital status, medical history and American Society of Anesthesiologists (ASA) grades between both groups. Logistic regression analysis showed that advanced age (≥85 years), male gender, and higher ASA grades (III-IV) were risk factors for short-term poor prognosis in elderly patients with hip fracture. Compared with survival group, NLR, PCT and CRP levels were higher in death group. ROC curve showed that the AUC of NLR predicting patients' prognosis was 0.804 at a cutoff value of 6.939%. K-M curves showed that the overall survival was lower in high-ratio group than in low-ratio group.

Conclusion: Advanced age (overall survival was lower in high-ratio group than in low-ratio group), male gender, and higher ASA grades (III-IV) were risk factors for short-term poor prognosis in elderly patients with hip rifracture. NLR has some clinical value in predicting and evaluating the prognosis of patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430054PMC
August 2021

Reduction and removal of Cr(VI) in water using biosynthesized palladium nanoparticles loaded Shewanella oneidensis MR-1.

Sci Total Environ 2021 Sep 15;805:150336. Epub 2021 Sep 15.

Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China. Electronic address:

In materials science, "green" synthesis has gotten a lot of interest as a reliable, long-lasting, and ecofriendly way to make a variety of materials/nanomaterials, including metal/metal oxide nanomaterials. To accommodate various biological materials, green synthesis of metallic nanoparticles has been used (e.g., bacteria, fungi, algae, and plant extracts). In this work, Shewanella oneidensis MR-1 was used to biosynthesize palladium nanoparticles (bioPd) under aerobic conditions for the Cr(VI) bio-reduction. The size and distribution of bio-Pd are controlled by adjusting the ratio of microbial biomass and palladium precursors. The high cell: Pd ratio has the smallest average particle size of 6.33 ± 1.69 nm. And it has the lowest electrocatalytic potential (-0.132 V) for the oxidation of formic acid, which is 0.158 V lower than commercial Pd/C (5%). Our results revealed that the small size and uniformly distributed extracellular bio-Pd could achieve completely catalytic reduction of 200 mg/L Cr(VI) solution within 10 min, while the commercial Pd/C (5%) need at least 45 min. The bio-Pd materials maintain a high reduction during five cycles. Microorganisms play an important role in the whole process, which can fully disperse palladium nanoparticles, completely reduce Cr(VI), and effectively adsorb Cr(III). This work expands our understanding and provides a reference for the design and development of efficient and green bio-Pd catalysts for environmental pollution control under simple and mild conditions.
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http://dx.doi.org/10.1016/j.scitotenv.2021.150336DOI Listing
September 2021

Anatomical observation and clinical significance of the left gastric vein in laparoscopic radical gastrectomy.

J Gastrointest Oncol 2021 Aug;12(4):1407-1415

Department of Gastrointestinal Surgery, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Background: The left gastric vein (LGV) plays an important role in laparoscopic radical gastrectomy (LRG). However, the anatomy of the LGV is complicated with significant variation, and it is often damaged and bleeding during LRG. The purpose of this study was to observe and analyze the anatomic types of the LGV in patients undergoing LRG and to explore its clinical significance.

Methods: A total of 217 patients who underwent LRG from June 2016 to December 2020 were included. LGVs were divided into four types according to the relationship between the LGV and peripheral arteries [celiac artery (CA)/common hepatic artery (CHA)/splenic artery (SA)] and the pancreas during LRG. If a LGV was damaged during surgery (resulting in bleeding), it was included in the bleeding group. Non-bleeding groups were included if there was no impairment to the LGV.

Results: A total of four types of LGVs were observed, of which type I was the most prevalent, accounting for 58.8% (n=121). In 21 patients (9.7%), the LGV was injured and hemorrhagic during LRG; and the type IV LGV injury bleeding rate was as high as 41.7% (5/12). Univariate analysis revealed that the extent of lymph node dissection (LND), pathological stage, tumor (T) stage, and type of LGV were significantly associated with LGV injury and hemorrhage (P<0.05). Multivariate analysis showed that enlarged LND, late T stage, late pathological stage, and type IV LGV were independent risk factors for LGV injury hemorrhage.

Conclusions: LGVs that run between the CHA (posterior) and the CA into the portal venous system were the most common anatomical type. A LGV that runs between the SA (posterior) and the CA into the portal venous system is easily injured (resulting in bleeding). LGV injury and hemorrhage are affected by a variety of factors, and therefore, careful intraoperative dissection is necessary to avoid damage to the LGV.
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http://dx.doi.org/10.21037/jgo-21-352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421885PMC
August 2021

A host lipase prevents lipopolysaccharide-induced foam cell formation.

iScience 2021 Sep 19;24(9):103004. Epub 2021 Aug 19.

Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Although microbe-associated molecular pattern (MAMP) molecules can promote cholesterol accumulation in macrophages, the existence of a host-derived MAMP inactivation mechanism that prevents foam cell formation has not been described. Here, we tested the ability of acyloxyacyl hydrolase (AOAH), the host lipase that inactivates gram-negative bacterial lipopolysaccharides (LPSs), to prevent foam cell formation in mice. Following exposure to small intraperitoneal dose(s) of LPSs, macrophages produced more low-density lipoprotein receptor and less apolipoprotein E and accumulated more cholesterol than did macrophages. The macrophages also maintained several pro-inflammatory features. Using a perivascular collar placement model, we found that mice developed more carotid artery foam cells than did mice after they had been fed a high fat, high cholesterol diet, and received small doses of LPSs. This is the first demonstration that an enzyme that inactivates a stimulatory MAMP can reduce cholesterol accumulation and inflammation in arterial macrophages.
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http://dx.doi.org/10.1016/j.isci.2021.103004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426562PMC
September 2021

Time-resolved analysis of photoluminescence at a single wavelength for ratiometric and multiplex biosensing and bioimaging.

Chem Sci 2021 Aug 26;12(33):11020-11027. Epub 2021 Jul 26.

State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Institute of Flexible Electronics (Future Technology), Nanjing University of Posts & Telecommunications Nanjing 210023 P. R. China

Simultaneous analysis of luminescence signals of multiple probes can improve the accuracy and efficiency of biosensing and bioimaging. Analysis of multiple signals at different wavelengths usually suffers from spectral overlap, possible energy transfer, and difference in detection efficiency. Herein, we reported a polymeric luminescent probe, which was composed of a phenothiazine-based fluorescent compound and a phosphorescent iridium(iii) complex. Both luminophores emitted at around 600 nm but their luminescence lifetimes are 160 times different, allowing time-resolved independent analysis. As the fluorescence was enhanced in response to oxidation by hypochlorite and the phosphorescence was sensitive toward oxygen quenching, a four-dimensional relationship between luminescence intensity, fluorescence/phosphorescence ratio, hypochlorite concentration, and oxygen content was established. In cellular imaging, time-resolved photoluminescence imaging microscopy clearly showed the independent fluorescence response toward hypochlorite and phosphorescence response toward oxygen in separated time intervals. This work opens up a new idea for the development of multiplex biosensing and bioimaging.
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http://dx.doi.org/10.1039/d1sc02811aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386655PMC
August 2021

Detection system of dead and sick chickens in large scale farms based on artificial intelligence.

Math Biosci Eng 2021 07;18(5):6117-6135

Nanjing Huazhu Industrial Intelligent Equipment Co., Ltd., Nanjing 211175, China.

With the continuous enrichment of scientific and technological means, the production of most chicken farms has been able to achieve automation, but for the dead and sick chickens in the farm, there is no automatic monitoring step, only through continuous manual inspection and discovery. In the face of this problem, there are many solutions to identify dead and sick chickens through sound and image, but they can not achieve the ideal effect. In this paper, a sensor detection method based on artificial intelligence is proposed. This method 1) The maximum displacement of chicken activity is measured by fastening a foot ring on each chicken, and the three-dimensional total variance is designed and calculated to represent the chicken activity intensity. 2) The detection terminal collects the sensing data of foot ring through ZigBee network. 3) The state of chicken (dead chicken and sick chicken) can be identified by machine learning algorithm. This method of artificial intelligence combined with sensor network not only has high recognition rate, but also can reduce the operation cost. The practical results show that the accuracy of the system to identify dead and sick chickens is 95.6%, and the cost of the system running for 4 years can be reduced by 25% compared with manual operation.
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http://dx.doi.org/10.3934/mbe.2021306DOI Listing
July 2021

Microwave-assisted synthesis of manganese oxide catalysts for total toluene oxidation.

J Colloid Interface Sci 2021 Aug 30;607(Pt 1):100-110. Epub 2021 Aug 30.

Graduate School of Science and Technology, Hirosaki University, 1-Bunkyocho, Hirosaki 036-8560, Japan; Energy Conversion Engineering Laboratory, Institute of Regional Innovation (IRI), Hirosaki University, 2-1-3 Matsubara, Aomori 030-0813, Japan. Electronic address:

Oxygen vacancy on the heterogeneous catalyst is of great importance to the catalysis of volatile organic compound (VOC) oxidation. Herein, microwave radiation with special energy-excitation is successfully utilized for the post-processing of a series of manganese oxides (MnO) to generate oxygen vacancies. It is found that the MnO catalyst with 60 min of microwave radiation demonstrates higher activity for toluene oxidation with a T of 210 °C and a T of 223 °C, which is attributed to the higher concentration of oxygen vacancies derived from the rich phase interface defects resulted from the microwave radiation. Furthermore, the Mn-MW-60 catalyst possesses excellent thermal stability and water vapor tolerance even under 20 vol% HO atmospheres within 60 h. In situ DRIFTS analysis verifies that both surface and lattice oxygen species simultaneously participate the oxidation process, and all reactions over different environments follows two different pathways. Meanwhile, it is proposed that those oxygen vacancies derived from microwave radiation could facilitate the rate-controlling step of opening the aromatic ring based on the electron back-donation, thereby leading to the increment of catalytic activity.
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http://dx.doi.org/10.1016/j.jcis.2021.08.170DOI Listing
August 2021

Transplantation of Extended Criteria Donor Livers Following Continuous Normothermic Machine Perfusion without Recooling.

Transplantation 2021 Sep 7. Epub 2021 Sep 7.

Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, P.R. China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China.

Introduction: Traditional liver transplant strategies with cold preservation usually result in ischemia reperfusion injury (IRI) to the donor liver. Regular normothermic machine perfusion (NMP) donor livers suffer IRI twice. Here, we aimed to introduce a novel technique called continuous normothermic machine perfusion (NMP) without recooling to avoid a second IRI and its application in livers from extended criteria donors (ECDs).

Materials And Methods: Seven donor livers transplanted following continuous NMP without recooling, 7 donor livers transplanted following standard NMP and 14 livers under static cold storage (SCS) were included in this study. Perioperative outcomes were recorded and analyzed between groups.

Result: During the NMP without a recooling procedure, all livers cleared lactate quickly to normal levels in a median time of 100 minutes (IQR 60~180) and remained stable until the end of perfusion. In the NMP without recooling and standard NMP groups, posttransplant peak aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were both significantly lower than those in the SCS group (P=0.0015 and 0.016, respectively). The occurrence rate of early allograft dysfunction (EAD) was significantly lower in the NMP without recooling group than in the SCS group (P=0.022), while there was no difference in the NMP group with or without recooling (P=0.462).

Conclusion: Our pilot study revealed a novel technique designed to avoid secondary IRI. This novel technique is shown to have at least a comparable effect to the standard NMP, though more data are needed to show its superiority in the future.
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http://dx.doi.org/10.1097/TP.0000000000003945DOI Listing
September 2021

Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma.

BMC Cancer 2021 Sep 7;21(1):1001. Epub 2021 Sep 7.

Organ Transplant Center, the First Affiliated Hospital, Sun Yat-Sen University, NO.58 Zhongshan Road, Guangzhou, 510080, China.

Background: The copper metabolism MURR1 domain (COMMD) protein family involved in tumor development and progression in several types of human cancer, but little is known about the function of COMMD proteins in hepatocellular carcinoma (HCC).

Methods: The ONCOMINE and the UALCAN databases were used to evaluate the expression of COMMD1-10 in HCC and the association of this family with individual cancer stage and tumor grade. Kaplan-Meier (K-M) Plotter and Cox analysis hint the prognostic value of COMMDs. A network comprising 50 most similar genes and COMMD1-10 was constructed with the STRING database. Gene set enrichment analysis (GSEA) was performed using LinkedOmics database. The correlations between COMMD expression and the presence of immune infiltrating cells were also analyzed by the tumor immune estimation resource (TIMER) database. GSE14520 dataset and 80 HCC patients were used to validated the expression and survival value of COMMD3. Human HCC cell lines were also used for validating the function of COMMD3.

Results: The expression of all COMMD family members showed higher expression in HCC tissues than that in normal tissues, and is associated with clinical cancer stage and pathological tumor grade. In HCC patients, the transcriptional levels of COMMD1/4 are positively correlated with overall survival (OS), while those of COMMD2/3/7/8/9 are negatively correlated with OS. Multivariate analysis indicated that a high level of COMMD3 mRNA is an independent prognostic factor for shorter OS in HCC patients. However, the subset of patients with grade 3 HCC, K-M survival curves revealed that high COMMD3/5/7/8/9 expression and low COMMD4/10 expression were associated with shorter OS. In addition, the expression of COMMD2/3/10 was associated with tumor-induced immune response activation and immune infiltration in HCC. The expression of COMMD3 from GSE14520 dataset and 80 patients are both higher in tumor than that in normal tissue, and a higher level of COMMD3 mRNA is associated with shorter OS. Knockdown of COMMD3 inhibits human HCC cell lines proliferation in vitro.

Conclusions: Our study indicates that COMMD3 is an independent prognostic biomarker for the survival of HCC patients. COMMD3 supports the proliferation of HCC cells and contributes to the poor OS in HCC patients.
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http://dx.doi.org/10.1186/s12885-021-08699-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424899PMC
September 2021

circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation.

Cancer Gene Ther 2021 Sep 1. Epub 2021 Sep 1.

Department of General Surgery, Heping Hospital, Changzhi Medical College, Changzhi City, Shanxi Province, China.

Accumulating research implicated that circular RNAs exhibited significant roles in cancer development. Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time PCR (qRT-PCR). Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3. circPTPN22 expression was highly upregulated in pancreatic cancer tissues and cell lines. Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment. Furthermore, STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction.
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http://dx.doi.org/10.1038/s41417-021-00382-wDOI Listing
September 2021

Encapsulation of lyophilized platelet-rich fibrin in alginate-hyaluronic acid hydrogel as a novel vascularized substitution for myocardial infarction.

Bioact Mater 2022 Jan 12;7:401-411. Epub 2021 Jun 12.

Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.

Cardiovascular diseases such as myocardial infarction (MI) are among the major causes of death worldwide. Although intramyocardial injection of hydrogels can effectively enhance the ventricular wall, this approach is limited because of its restriction to the poor vascularization in the infarcted myocardium. Here, we reported a new type of hydrogel composed of alginate (ALG) and hyaluronic acid (HA) with lyophilized platelet-rich fibrin (Ly-PRF) for releasing abundant growth factors to realize their respective functions. The results of in vitro studies demonstrated favorable mechanical property and release ability of ALG-HA with Ly-PRF. When injected into the infarcted myocardium, this composite hydrogel preserved heart function and the Ly-PRF within the hydrogel promoted angiogenesis and increased vascular density in both infarcted and border zone, which rescued the ischemic myocardium. These beneficial effects were also accompanied by macrophage polarization and regulation of myocardial fibrosis. Moreover, the autologous origin of Ly-PRF with ALG-HA hydrogel offers myriad advantages including safety profile, easiness to obtain and cost-effectiveness. Overall, this study demonstrated the versatile therapeutic effects of a novel composite hydrogel ALG-HA with Ly-PRF, which optimizes a promising vascularized substitution strategy for improving cardiac function after MI.
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http://dx.doi.org/10.1016/j.bioactmat.2021.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379365PMC
January 2022

Three-dimensional self-supporting catalyst with NiFe alloy/oxyhydroxide supported on high-surface cobalt hydroxide nanosheet array for overall water splitting.

J Colloid Interface Sci 2021 Aug 14;606(Pt 1):873-883. Epub 2021 Aug 14.

College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, PR China; Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization, Taiyuan, Shanxi 030024, PR China. Electronic address:

The development of available dual-function electrocatalysts is of great significance to the effective storage of excess electricity. Here, we obtained a three-dimensional Co(OH) nanosheet with high surface area on nickel foam (Co(OH)/NF) via conventional hydrothermal. NiFe-coated Co(OH) nanosheet array ([email protected](OH) NSAs/NF) was further constructed by electrodeposition for water splitting. By optimizing and regulating the deposition time, [email protected](OH) NSAs/NF with a deposition time of 500 s ([email protected](OH) NSAs/NF) only needs 98 mV of overpotential and can be stabilized for 100 h for hydrogen evolution at 10 mA cm due to the rich density active components for NiFe alloy/oxyhydroxide layer and interaction with Co(OH) nanosheets. Thanks to the excellent 3D nanosheet array structure and the close integration between Co(OH) and the upper layer NiFe, [email protected](OH) NSAs/NF with a deposition time of 200 s ([email protected](OH) NSAs/NF) can provide 10 mA cm with only 204 mV and maintain constant catalysis within 100 h. Therefore, the constructed [email protected](OH) NSAs/NF (500||200) double-electrode cell for water splitting requires only 1.58 V drive potential and can maintain 24 h durability at 10 mA cm. The design of the catalyst opens up new ideas for the large-scale application of transition metals in water splitting.
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http://dx.doi.org/10.1016/j.jcis.2021.08.020DOI Listing
August 2021

Utility of Advanced DWI in the Detection of Spinal Cord Microstructural Alterations and Assessment of Neurologic Function in Cervical Spondylotic Myelopathy Patients.

J Magn Reson Imaging 2021 Aug 23. Epub 2021 Aug 23.

Department of Radiology, Peking University Third Hospital, Beijing, China.

Background: Diffusion-weighted imaging (DWI) can quantify the microstructural changes in the spinal cord. It might be a substitute for T2 increased signal intensity (ISI) for cervical spondylotic myelopathy (CSM) evaluation and prognosis.

Purpose: The purpose of the study is to investigate the relationship between DWI metrics and neurologic function of patients with CSM.

Study Type: Retrospective.

Population: Forty-eight patients with CSM (18.8% females) and 36 healthy controls (HCs, 25.0% females).

Field Strength/sequence: 3 T; spin-echo echo-planar imaging-DWI; turbo spin-echo T1/T2; multi-echo gradient echo T2*.

Assessment: For patients, conventional MRI indicators (presence and grades of T2 ISI), DWI indicators (neurite orientation dispersion and density imaging [NODDI]-derived isotropic volume fraction [ISOVF], intracellular volume fraction, and orientation dispersion index [ODI], diffusion tensor imaging [DTI]-derived fractional anisotropy [FA] and mean diffusivity [MD], and diffusion kurtosis imaging [DKI]-derived FA, MD, and mean kurtosis), clinical conditions, and modified Japanese Orthopaedic Association (mJOA) were recorded before the surgery. Neurologic function improvement was measured by the 3-month follow-up recovery rate (RR). For HCs, DWI, and mJOA were measured as baseline comparison.

Statistical Tests: Continuous (categorical) variables were compared between patients and HCs using Student's t-tests or Mann-Whitney U tests (chi-square or Fisher exact tests). The relationships between DWI metrics/conventional MRI findings, and the pre-operative mJOA/RR were assessed using correlation and multivariate analysis. P < 0.05 was considered statistically significant.

Results: Among patients, grades of T2 ISI were not correlated with pre-surgical mJOA/RR (P = 0.717  and 0.175, respectively). NODDI ODI correlated with pre-operative mJOA (r = -0.31). DTI FA, DKI FA, and NODDI ISOVF were correlated with the recovery rate (r = 0.31, 0.41, and -0.34, respectively). In multivariate analysis, NODDI ODI (DTI FA, DKI FA, NODDI ISOVF) significantly contributed to the pre-operative mJOA (RR) after adjusting for age.

Data Conclusion: DTI FA, DKI FA, and NODDI ISOVF are predictors for prognosis in patients with CSM. NODDI ODI can be used to evaluate CSM severity.

Level Of Evidence: 3 TECHNICAL EFFICACY STAGE: 5.
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http://dx.doi.org/10.1002/jmri.27894DOI Listing
August 2021

WS moiré superlattices derived from mechanical flexibility for hydrogen evolution reaction.

Nat Commun 2021 Aug 20;12(1):5070. Epub 2021 Aug 20.

State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts & Telecommunications, Nanjing, China.

The discovery of moiré superlattices (MSLs) opened an era in the research of 'twistronics'. Engineering MSLs and realizing unique emergent properties are key challenges. Herein, we demonstrate an effective synthetic strategy to fabricate MSLs based on mechanical flexibility of WS nanobelts by a facile one-step hydrothermal method. Unlike previous MSLs typically created through stacking monolayers together with complicated method, WS MSLs reported here could be obtained directly during synthesis of nanobelts driven by the mechanical instability. Emergent properties are found including superior conductivity, special superaerophobicity and superhydrophilicity, and strongly enhanced electro-catalytic activity when we apply 'twistronics' to the field of catalytic hydrogen production. Theoretical calculations show that such excellent catalytic performance could be attributed to a closer to thermoneutral hydrogen adsorption free energy value of twisted bilayers active sites. Our findings provide an exciting opportunity to design advanced WS catalysts through moiré superlattice engineering based on mechanical flexibility.
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http://dx.doi.org/10.1038/s41467-021-25381-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379161PMC
August 2021

Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform trajectory and strategy of hybrid rice breeding.

Mol Plant 2021 Aug 11. Epub 2021 Aug 11.

National Center for Gene Research, State Key Laboratory of Plant Molecular Genetics, Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200233, China. Electronic address:

The male sterility (MS) line is a prerequisite for self-pollinating rice to efficiently produce hybrid seeds. MS line breeding is pivotal for hybrid rice improvement. Understanding the historical breeding trajectory will be helpful to improve hybrid rice breeding strategy. Maternally inherited cytoplasm is an appropriate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids. In this study, we analyzed the cytoplasmic genomes of 1,495 elite hybrid rice varieties, and identified 5 major types of cytoplasms, which were corresponding to different hybrid production systems. As the cytoplasm donor for hybrid, 461 MS lines were also divided into 5 major types based on the cytoplasmic and nuclear genomic architecture. And the specific core accessions cooperated with fertility-associated genes drove the sequence divergence of MS lines. Dozens to hundreds of convergent and divergent selective sweeps among different types of MS lines were identified, which spanned several agronomic trait-associated genes. We further summarized the cross pattern between different types of MS lines and corresponding restorers, respectively. This study systematically analyzed the cytoplasmic genome of rice hybrid for the first time, revealed its association with nuclear genome of MS lines, further conducted classification based on variations from both genomes, and provided new insights into hybrid rice breeding.
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http://dx.doi.org/10.1016/j.molp.2021.08.007DOI Listing
August 2021

A superhydrophobic chip integrated with an array of medium reservoirs for long-term hanging drop spheroid culture.

Acta Biomater 2021 Aug 10. Epub 2021 Aug 10.

Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Defence Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400044, China. Electronic address:

Hanging drop (HD) is one of the most popular methods used for forming three-dimensional (3D) cell spheroids. However, conventional hanging drop systems are only applicable for short-term spheroid culture due to their inconvenience in exchanging cell culture media. Here we present a medium-reservoir-integrated superhydrophobic (MRI-SH) chip for long-term HD spheroid cultures. The device consists of two main components: i) a patterned superhydrophobic (SH) surface containing an array of wettable spots which anchor arrays of droplets of cell suspension, and ii) an array of chambers that serve as medium reservoirs, both interconnected via an array of thru-holes. This configuration provides two distinct advantages over conventional HD configurations: i) the high wettability contrast of the SH pattern on the chip leads to the formation and adhesion of nearly spherical hanging droplets on its surface, which minimizes interactions between the liquid and the substrate; ii) the integrated chambers provide large volumes of medium to maintain longer culture durations. Using this device, spheroids of MHCC97H cells were successfully formed, and the cultured spheroids could maintain high viability for up to 30 days and exhibited enhanced spheroid morphology compared to those cultured in the conventional HD systems. STATEMENT OF SIGNIFICANCE: This paper presents a medium-reservoir-integrated superhydrophobic hanging drop (HD) platform for the long-term culture of spheroids with enhanced morphology. By monolithically integrating medium reservoirs and a patterned SH surface into a single device, this HD platform can not only produce high-quality spheroids, but also permit them to sustain high viability for up to 30 days without the need for tedious medium replenishment. We believe that such a platform will be valuable in a wide range of biological or biomedical applications, including tissue engineering, regenerative medicine, and drug discovery.
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http://dx.doi.org/10.1016/j.actbio.2021.08.006DOI Listing
August 2021

Prediction of post-transplant graft survival by different definitions of early allograft dysfunction.

Ann Palliat Med 2021 Aug 2;10(8):8584-8595. Epub 2021 Aug 2.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China; Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China.

Background: The efficacy of early allograft dysfunction (EAD) definitions in predicting post-transplant graft survival in a Chinese population is still unclear.

Methods: A total of 607 orthotopic liver transplants (OLT) have been included in the current study. Model accuracy was evaluated using receiver operating characteristic (ROC) analysis. Risk factors for EAD was evaluated using univariable analysis and multivariable logistic regression model.

Results: The 3-, 6-, and 12-month patient/graft survival were 91.6%/91.4%, 91.1%/90%, and 87.5%/87.3%, respectively. MELDPOD5 had a superior discrimination of 3-month graft survival (C statistic, 0.83), compared with MEAF (C statistic, 0.77) and Olthoff criteria (C statistic, 0.72). Multivariate analysis of risk factors for EAD defined by MELDPOD5, showed that donor body mass index (P=0.001), donor risk index (P=0.006), intraoperative use of packed red blood cells (P=0.001), hypertension of recipient (P=0.004), and preoperative total bilirubin (P<0.001) were independent risk factors.

Conclusions: The results suggest that MLEDPOD5 is a better criterion of EAD for the Chinese population, which might serve as a surrogate end-point for graft survival in clinical study.
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http://dx.doi.org/10.21037/apm-21-1012DOI Listing
August 2021

Memristors Based on an Iridium(III) Complex Containing Viologen for Advanced Synaptic Bionics.

Inorg Chem 2021 Sep 11;60(17):13021-13028. Epub 2021 Aug 11.

State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, P. R. China.

Memristors with nonvolatile memory properties are expected to open the era of neuromorphic computing. However, it remains a huge challenge to develop memristors with high uniformity, high stability, and low power consumption for advanced synaptic bionics. Herein, an electroactive iridium(III) complex was designed and synthesized by incorporating a viologen moiety into its NN ligand. Complex showed multiple redox states and high sensitivity to an electrical stimulus. Importantly, two-terminal memristors with Ag//W structure were successfully fabricated by the solution-processable method, which exhibited multilevel storage characteristics with a low switching threshold voltage of 0.5 V and high ON1/ON2/ON3/OFF current ratio of 10/10/10/1 at a low reading bias of 0.05 V. Moreover, the memristors can mimic synaptic plasticity, indicating that they can act as artificial synapses to construct brain-inspired neural networks. The memristive mechanisms can be ascribed to the interconversion among different charge-transfer and redox states under various electrical stimulus. To the best of our knowledge, this work is the first experimental demonstration of memristors based on iridium(III) complexes, opening a new era for the development of synaptic bionic devices based on organometallic compounds.
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http://dx.doi.org/10.1021/acs.inorgchem.1c01439DOI Listing
September 2021

Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus.

Int J Gen Med 2021 27;14:4017-4023. Epub 2021 Jul 27.

Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272029, People's Republic of China.

Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM).

Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS).

Results: The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (<0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was <4.17 mg/dl (β 0.12,95% CI -0.04, 0.28; =0.121) and decreased when UA was >4.17 mg/dl (β -0.38,95% CI -0.64, -0.12; =0.004).

Conclusion: This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.
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http://dx.doi.org/10.2147/IJGM.S323579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326926PMC
July 2021

Superfast Water Transport Zwitterionic Polymeric Nanofluidic Membrane Reinforced by Metal-Organic Frameworks.

Adv Mater 2021 Sep 4;33(38):e2102292. Epub 2021 Aug 4.

Center for Membrane and Water Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China.

Nanofluidics derived from low-dimensional nanosheets and protein nanochannels are crucial for advanced catalysis, sensing, and separation. However, polymer nanofluidics is halted by complicated preparation and miniaturized sizes. This work reports the bottom-up synthesis of modular nanofluidics by confined growth of ultrathin metal-organic frameworks (MOFs) in a polymer membrane consisting of zwitterionic dopamine nanoparticles (ZNPs). The confined growth of the MOFs on the ZNPs reduces the chain entanglement between the ZNPs, leading to stiff interfacial channels enhancing the nanofluidic transport of water molecules through the membrane. As such, the water permeability and solute selectivity of [email protected] are one magnitude improved, leading to a record-high performance among all polymer nanofiltration membranes. Both the experimental work and the molecular dynamics simulations confirm that the water transport is shifted from high-friction-resistance conventional viscous flow to ultrafast nanofluidic flow as a result of rigid and continuous nanochannels in [email protected]
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http://dx.doi.org/10.1002/adma.202102292DOI Listing
September 2021

AtMYB32 regulates the ABA response by targeting ABI3, ABI4 and ABI5 and the drought response by targeting CBF4 in Arabidopsis.

Plant Sci 2021 Sep 21;310:110983. Epub 2021 Jun 21.

College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan Hybrid Rape Engineering and Technology Research Center, Hunan University, Changsha, 410082, China; Shenzhen Institute, Hunan University, Shenzhen, 518057, China. Electronic address:

The Arabidopsis thaliana R2R3-MYB transcription factor AtMYB32 and its homologs AtMYB4 and AtMYB7 play crucial roles in the regulation of phenylpropanoid metabolism. In addition, AtMYB4 and AtMYB7 are involved in the response to abiotic stress. However, the function of AtMYB32 remains unclear. In this study, we found that AtMYB32 is induced by abscisic acid (ABA) and repressed by drought stress. AtMYB32 positively regulates ABA-mediated seed germination and early seedling development. The expression of ABSCISIC ACID-INSENSITIVE 3 (ABI3), ABI4 and ABI5, which encode key positive regulators of ABA signaling, was upregulated in response to ABA in AtMYB32-overexpressing plants and downregulated in the atmyb32-1 mutant. In addition, we found that the atmyb32-1 mutant was drought resistant. Consistent with the drought-resistant phenotype, the transcript levels of C-repeat binding factor 4 (CBF4) were higher in the atmyb32-1 mutant in response to drought stress. Electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation (ChIP) assays revealed that AtMYB32 binds directly to the ABI3, ABI4, ABI5 and CBF4 promoters both in vitro and in vivo. Genetically, ABI4 was found to be epistatic to AtMYB32 for ABA-induced inhibition of seed germination and early seedling development. Taken together, our findings revealed that AtMYB32 regulates the ABA response by directly promoting ABI3, ABI4 and ABI5 expression and that the drought stress response likely occurs because of repression of CBF4 expression.
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http://dx.doi.org/10.1016/j.plantsci.2021.110983DOI Listing
September 2021

Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery.

Nat Commun 2021 07 23;12(1):4501. Epub 2021 Jul 23.

State key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin, China.

Nitric oxide (NO) is a short-lived signaling molecule that plays a pivotal role in cardiovascular system. Organic nitrates represent a class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation of systemic vasculature that often leads to adverse effects. Herein, we design a nitrate-functionalized patch, wherein the nitrate pharmacological functional groups are covalently bound to biodegradable polymers, thus transforming small-molecule drugs into therapeutic biomaterials. When implanted onto the myocardium, the patch releases NO locally through a stepwise biotransformation, and NO generation is remarkably enhanced in infarcted myocardium because of the ischemic microenvironment, which gives rise to mitochondrial-targeted cardioprotection as well as enhanced cardiac repair. The therapeutic efficacy is further confirmed in a clinically relevant porcine model of myocardial infarction. All these results support the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs.
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http://dx.doi.org/10.1038/s41467-021-24804-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302626PMC
July 2021

Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo.

Nat Commun 2021 07 20;12(1):4395. Epub 2021 Jul 20.

Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Although previous studies have focused on the design and synthesis of self-healing materials, their application in in vivo settings remains limited. Here, we design a series of biodegradable and biocompatible self-healing elastomers (SHEs) with tunable mechanical properties, and apply them to various disease models in vivo, in order to test their reparative potential in multiple tissues and at physiological conditions. We validate the effectiveness of SHEs as promising therapies for aortic aneurysm, nerve coaptation and bone immobilization in three animal models. The data presented here support the translation potential of SHEs in diverse settings, and pave the way for the development of self-healing materials in clinical contexts.
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http://dx.doi.org/10.1038/s41467-021-24680-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292539PMC
July 2021

Single-atom Pt-I sites on all-inorganic CsSnI perovskite for efficient photocatalytic hydrogen production.

Nat Commun 2021 Jul 20;12(1):4412. Epub 2021 Jul 20.

School of Materials Science and Engineering, Peking University, Beijing, P. R. China.

Organic-inorganic lead halide perovskites are a new class of semiconductor materials with great potential in photocatalytic hydrogen production, however, their development is greatly plagued by their low photocatalytic activity, instability of organic component and lead toxicity in particular. Herein, we report an anti-dissolution environmentally friendly CsSnI perovskite anchored with a new class of atomically dispersed Pt-I species (PtSA/CsSnI) for achieving the highly efficient photocatalytic hydrogen production in HI aqueous solution at room temperature. Particularly, we discover that CsSnI in PtSA/CsSnI has a greatly enhanced tolerance towards HI aqueous solution, which is very important for achieving excellent photocatalytic stability in perovskite-based HI splitting system. Remarkably, the PtSA/CsSnI catalyst shows a superb photocatalytic activity for hydrogen production with a record turnover frequency of 70.6 h per Pt, about 176.5 times greater than that of Pt nanoparticles supported CsSnI perovskite, along with superior cycling durability. Charge-carrier dynamics studies in combination with theory calculations reveal that the dramatically boosted photocatalytic performance on PtSA/CsSnI originates from both unique coordination structure and electronic property of Pt-I sites, and strong metal-support interaction effect that can not only greatly promote the charge separation and transfer, but also substantially reduce the energy barrier for hydrogen production. This work opens a new way for stimulating more research on perovskite composite materials for efficient hydrogen production.
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http://dx.doi.org/10.1038/s41467-021-24702-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292376PMC
July 2021
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