Publications by authors named "Qiang Li"

4,203 Publications

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High Concentrations of Triglycerides are Associated with Diabetic Kidney Disease in New-onset Type 2 Diabetes in China: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.

Diabetes Obes Metab 2021 Jul 28. Epub 2021 Jul 28.

Karamay Municipal People's Hospital, Xinjiang, China.

Aims: The aims of this study were to evaluate the associations of metabolic abnormalities with incident DKD and to explore whether dyslipidemia, especially high fasting triglyceride (TG), was associated with the development of DKD.

Methods: A total of 11 142 new-onset type 2 diabetes patients with a baseline estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m were followed up during 2011-2016. Incident DKD was defined as eGFR <60 mL/min/1.73m at follow-up. Multiple logistic regression analysis was conducted to explore the relationship of metabolic abnormalities at baseline and at follow-up with risks of DKD. High TG was defined by TG ≥1.70 mmol/L. Low high-density lipoprotein cholesterol (HDL-c) was defined by HDL-c < 1.0 mmol/L for men or < 1.3 mmol/L for women.

Results: Participants who developed DKD had higher levels of waist circumference and systolic blood pressure, and lower levels of HDL-c at both baseline and follow-up visits. The DKD group also had higher levels of post-load plasma glucose and TG at follow-up. Multivariate logistic regression analysis revealed that both high TG at baseline (odds ratio, OR = 1.37, P = 0.012) and high TG at follow-up (OR = 1.71, P < 0.001) were significantly associated with increased risks of DKD. Patients with high TG levels at both baseline and follow-up had higher risk of DKD compared with constantly normal TG (OR = 1.65, P < 0.001) after adjustment for covariates.

Conclusions: In a large population of new-onset type 2 diabetes patients, high TG level was an independent risk factor for the development of DKD. Tight TG control might delay the occurrence of DKD. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1111/dom.14502DOI Listing
July 2021

Effects of China's ecological restoration on economic development based on Night-Time Light and NDVI data.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

School of Finance, Zhongnan University of Economics and Law, Wuhan, 430073, China.

Correctly understanding and handling the relationship between economic development and environment protection is an eternal subject for human society. Based on the panel data of 31 provincial administrative units in China from 2000 to 2013, this study used Normalized Difference Vegetation Index (NDVI) and Night-Time Light data to characterize the effect of ecological restoration practices and economic development, respectively, and made an empirical study on the impact of ecological restoration on economic development by means of trend analysis, panel regression model, and subsample analysis. The results showed that the spatial distribution of Night-Time Light was high in the east and low in the west, and the NDVI in the northwest of the Hu Line was generally low, while the southeast was higher. During the 14 years from 2000 to 2013, the overall vegetation coverage showed an upward trend, and the area with stable night lights accounted for the largest proportion. The influence of NDVI on Night-Time Light presented an inverted U-shaped relationship, which meant that the negative influence of the former on the latter was not an inevitable result but its periodic performance. In the process of economic development, there was an optimal value of vegetation coverage. The increase in vegetation coverage had a negative impact on the economic development of the eastern region, but it was beneficial to the central and western regions. In the future, the government should strengthen protection and restoration of ecosystem, promote high-level protection of environment and high-quality development with efficient environmental and economic policies, and differentiate the relationship between development and ecology in the eastern, central, and western regions.
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http://dx.doi.org/10.1007/s11356-021-15595-7DOI Listing
July 2021

Contamination With Fumonisin B and Deoxynivalenol Is a Threat to Egg Safety and Contributes to Gizzard Ulcerations of Newborn Chickens.

Front Microbiol 2021 12;12:676671. Epub 2021 Jul 12.

College of Life Science and Engineering, Foshan University, Foshan, China.

Fumonisin B (FB) and other fumonisins, deoxynivalenol (DON), and zearalenone (ZEN) are mycotoxins (secondary metabolites of fungi) present at high levels of contamination in poultry diets and threatening the sustainability of the poultry industry and egg safety for consumers. However, residual mycotoxins in breeder eggs and their effects on chicken progeny and gizzard ulcerations remain unclear. To unveil mycotoxin contaminations from daily diets to breeder eggs, 293 poultry feed samples were collected from three large-scale poultry provinces across Northern China to Southern China. Average levels of 1,628 ± 4.36 μg/kg of FB, 593 ± 11.16 μg/kg of DON, 69 ± 9.21 μg/kg of ZEN, 52 ± 7.33 μg/kg of OTA, and 24 ± 5.85 μg/kg of AFB were found in feedstuffs and poultry diets using commercial ELISA kits. In terms of residual mycotoxins in breeder eggs, FB and DON contaminations dominated residues in egg albumen and yolk samples. Out of 221 breeder eggs, the average residual of FB in albumen were 320.6 ± 10.12 μg/kg (Hebei), 420.2 ± 10.98 μg/kg (Guangdong), and 549.4 ± 10.27 (Guangxi). Moreover, higher residual of DONs were determined in Guangdong and Guangxi provinces compared to Hebei province. ZEN, ochratoxins A (OTA), and aflatoxin B (AFB) contamination at low levels were found in the above samples collected from afronmentioned three provinces. Based on residual mycotoxins in breeder eggs, SPF embryonated eggs aged 11 days were inoculated into albumen with different doses of FB, FB or DON, or a combination of FB and DON, or a combination of FB with FB and FB. A lower hatching rate was observed in the chicken progenies with the combination of 24 μg of FB and 0.1 μg of DON compared to other treatments. Moreover, typical gizzard ulcerations with hemorrhagic lungs were observed in the progeny of breeder eggs post-inoculation of 24 μg of FB and synergetic inoculation of FB and DON. Finally, residual FB mycotoxins were detected in the gizzards and in the lungs of the progenies. Based on the above evidence, feed-borne FB and DON are dominant mycotoxins in breeder eggs and threatening food security using breeder eggs as a Trojan horse. More importantly, the residual of FB alone and in combination with of DON contamination are associated with low hatching rate and gizzard ulcerations in chicken progenies, hampering sustainable development perspectives of the poultry industry.
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http://dx.doi.org/10.3389/fmicb.2021.676671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312546PMC
July 2021

Too many streams and not enough time or money? Analytical depletion functions for streamflow depletion estimates.

Ground Water 2021 Jul 28. Epub 2021 Jul 28.

Foundry Spatial Ltd. 3947 Quadra St, Victoria, British Columbia, V8X 1J5, Canada.

Groundwater pumping can cause streamflow depletion by reducing groundwater discharge to streams and/or inducing surface water infiltration. Analytical and numerical models are two standard methods used to predict streamflow depletion. Numerical models require extensive data and efforts to develop robust estimates, while analytical models are easy to implement with low data and experience requirements but are limited by numerous simplifying assumptions. We have pioneered a novel approach that balances the shortcomings of analytical and numerical models: analytical depletion functions (ADFs), which include empirical functions expanding the applicability of analytical models for real-world settings. In this paper, we outline the workflow of ADFs and synthesize results showing that the accuracy of ADFs compared against a variety of numerical models from simplified, archetypal models to sophisticated, calibrated models in both steady-state and transient conditions over diverse hydrogeological landscapes, stream networks, and spatial scales. Like analytical models, ADFs are rapidly and easily implemented and have low data requirements but have significant advantages of better agreement with numerical models and better representation of complex stream geometries. Relative to numerical models, ADFs have limited ability to explore non-pumping related impacts and incorporate subsurface heterogeneity. In conclusion, ADFs can be used as a stand-alone tool or part of decision-support tools as preliminary screening of potential groundwater pumping impacts when issuing new and existing water licenses while ensuring streamflow meets environmental flow needs.
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http://dx.doi.org/10.1111/gwat.13124DOI Listing
July 2021

miR-4323 targets hepatoma-derived growth factor (HDGF) to suppress colorectal cancer cell proliferation.

Pathol Res Pract 2021 Jul 9;225:153544. Epub 2021 Jul 9.

Yunnan Cancer Center, The Third Affiliated Hospital of Kunming Medical University, Kunzhou Road 519, Kunming 650106, Yunnan, People's Republic of China.

MicroRNAs (miRNAs) are regulators of cancer progression via directly binding to the 3' untranslated region (3'UTR) of target genes to control the activity of signaling network. Recent studies have revealed the function of several miRNAs in colorectal cancer, however, there are still numerous miRNAs which have not been studied yet. Herein, we showed that miR-4323 was a downregulated miRNA according to previous microarray data. The downregulation of miR-4323 was further confirmed in colorectal tumors via RT-qPCR. miR-4323 overexpression decreased cell proliferation rate via induction of cell apoptosis in colorectal cancer cells. Mechanistically, miR-4323 decreased β-catenin and its downstream genes including c-Myc and MMP9 in colorectal cancer cells, indicating the inactivation of Wnt signaling. HDGF, an anti-apoptotic protein, was predicted by several software as a potential target of miR-4323. HDGF was experimentally verified as a target gene of miR-4323 using dual luciferase reporter assay. Ectopic expression of HDGF attenuated the effect of miR-4323 on cell proliferation and apoptosis in cells. Altogether, the data demonstrate a critical role of miR-4323 in the regulation of colorectal cancer.
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http://dx.doi.org/10.1016/j.prp.2021.153544DOI Listing
July 2021

Why do strategies to strengthen primary health care succeed in some places and fail in others? Exploring local variation in the effectiveness of a community health worker managed digital health intervention in rural India.

BMJ Glob Health 2021 Jul;6(Suppl 5)

The George Institute for Global Health, Newtown, New South Wales, Australia.

Introduction: Digital health interventions (DHIs) have huge potential as support modalities to identify and manage cardiovascular disease (CVD) risk in resource-constrained settings, but studies assessing them show modest effects. This study aims to identify variation in outcomes and implementation of SMARTHealth India, a cluster randomised trial of an ASHA-managed digitally enabled primary healthcare (PHC) service strengthening strategy for CVD risk management, and to explain how and in what contexts the intervention was effective.

Methods: We analysed trial outcome and implementation data for 18 PHC centres and collected qualitative data via focus groups with ASHAs (n=14) and interviews with ASHAs, PHC facility doctors and fieldteam mangers (n=12) Drawing on principles of realist evaluation and an explanatory mixed-methods design we developed mechanism-based explanations for observed outcomes.

Results: There was substantial between-cluster variation in the primary outcome (overall: I=62.4%, p<=0.001). The observed heterogeneity in trial outcomes was not attributable to any single factor. Key mechanisms for intervention effectiveness were community trust and acceptability of doctors' and ASHAs' new roles, and risk awareness. Enabling local contexts were seen to evolve over time and in response to the intervention. These included obtaining legitimacy for ASHAs' new roles from trusted providers of curative care; ASHAs' connections to community and to qualified providers; their responsiveness to community needs; and the accessibility, quality and appropriateness of care provided by higher level medical providers, including those outside of the implementing (public) subsystem.

Conclusion: Local contextual factors were significant influences on the effectiveness of this DHI-enabled PHC service strategy intervention. Local adaptions need to be planned for, monitored and responded to over time. By identifying plausible explanations for variation in outcomes between clusters, we identify potential strategies to strengthen such interventions.
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http://dx.doi.org/10.1136/bmjgh-2021-005003DOI Listing
July 2021

The application of "Gesture teaching method" in the course of explaining rotator cuff injury.

Asian J Surg 2021 Jul 23. Epub 2021 Jul 23.

Inner Mongolia Medical University, Department of Orthopedics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2021.07.005DOI Listing
July 2021

Gender-specific association between carbohydrate consumption and blood pressure in Chinese adults.

BMJ Nutr Prev Health 2021 13;4(1):80-89. Epub 2021 Jan 13.

Department of Epidemiology and Biostatistics, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Background: The association between dietary carbohydrate consumption and blood pressure (BP) is controversial. The present study aimed to evaluate the possible gender-specific association of carbohydrate across the whole BP distribution.

Method: Cross-sectional survey including 2241 rural adults was conducted in northwestern China in 2010. BP was measured by trained medical personnel. Dietary information was collected by semiquantitative Food-Frequency Questionnaire. Multivariate quantile regression model was used to estimate the association between total carbohydrates consumption and systolic BP (SBP) and diastolic BP (DBP) at different quantiles. Gender-specific β coefficient and its 95% CI was calculated.

Results: The average carbohydrate intake was 267.4 (SD 112.0) g/day in males and 204.9 (SD 90.7) g/day in females, with only 10.6% of males and 6.5% females consumed at least 65% of total energy from carbohydrates. And more than 80% carbohydrates were derived from refined grains. In females, increased total carbohydrates intake was associated with adverse SBP and DBP. An additional 50 g carbohydrates per day was positively associated with SBP at low and high quantiles (10th-20th and 60th-80th) and with DBP almost across whole distribution (30th-90th), after adjusting for age, fortune index, family history of hypertension, body mass index, physical activity level, alcohol intake and smoke, energy, two nutrient principal components, protein and sodium intake. Both relatively low and high carbohydrate intake were associated with increased SBP, with minimum level observed at 130-150 g carbohydrate intake per day from restricted cubic splines. However, no significant associations were observed in males.

Conclusions: Higher total carbohydrates consumption might have an adverse impact on both SBP and DBP in Chinese females but not males. Additionally, the positive association varies across distribution of BP quantiles. Further research is warranted to validate these findings and clarify the causality.
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http://dx.doi.org/10.1136/bmjnph-2020-000165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258083PMC
January 2021

Thermal Behavior of Oil Shale Pyrolysis under Low-Temperature Co-Current Oxidizing Conditions.

ACS Omega 2021 Jul 7;6(28):18074-18083. Epub 2021 Jul 7.

College of Construction Engineering, Jilin University, Changchun 130021, China.

The thermal behavior of the Huadian oil shale during low-temperature co-current oxidizing pyrolysis was studied by lab-scale experiments under different basic pyrolysis temperatures and input gas flow rates. The results showed that, in the process of oil shale co-current oxidizing pyrolysis, the increasing input gas flow rates under the same basic pyrolysis temperatures can significantly enhance the heat generation of oil shale. Meanwhile, it can be seen from the temperature variation characteristics of oil shale that the heat released by the oxidation reaction of semicoke and oxygen is enough to support the thermal decomposition of organic matter without supplemental heating. Moreover, it can be concluded from the 92.06% effective recovery of shale oil that a high yield of oil without a significant loss can be achieved. Finally, compared with increasing basic pyrolysis temperatures, the increased input gas flow rates have a more obvious effect on improving the effective recovery of shale oil.
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http://dx.doi.org/10.1021/acsomega.1c01875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296611PMC
July 2021

COVID-19 or treatment associated immunosuppression may trigger hepatitis B virus reactivation: A case report.

World J Clin Cases 2021 Jul;9(19):5266-5269

Department of Infectious Diseases, The Affiliated People's Hospital of Ningbo University, Ningbo 315040, Zhejiang Province, China.

Background: Since the initial recognition of coronavirus disease 2019 (COVID-19) in Wuhan, this infectious disease has spread to most areas of the world. The pathogenesis of COVID-19 is yet unclear. Hepatitis B virus (HBV) reactivation occurring in COVID-19 patients has not yet been reported.

Case Summary: A 45-year-old hepatitis B man with long-term use of adefovir dipivoxil and entecavir for antiviral therapy had HBV reactivation after being treated with methylprednisolone for COVID-19 for 6 d.

Conclusion: COVID-19 or treatment associated immunosuppression may trigger HBV reactivation.
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http://dx.doi.org/10.12998/wjcc.v9.i19.5266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283611PMC
July 2021

Antinociceptive C-diterpenoid alkaloids from the root of .

J Asian Nat Prod Res 2021 Jul 24:1-7. Epub 2021 Jul 24.

Department of Outpatient, General Hospital of Northern Theater Command, Shenyang 110000, China.

A chemical investigation on the roots of afforded three undescribed aconitine-type C-diterpenoid alkaloids, episcopalines A-C (). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested for their antinociceptive properties. As a result, episcopaline B () showed potent antinociceptive effect and its ID value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
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http://dx.doi.org/10.1080/10286020.2021.1956907DOI Listing
July 2021

Anti-tumour effect of neo-antigen-reactive T cells induced by RNA mutanome vaccine in mouse lung cancer.

J Cancer Res Clin Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Purpose: Mutation-specific T-cell response to epithelial cancers and T-cell-based immunotherapy has been successfully used to treat several human solid cancers. We aimed to investigate the anti-tumour effect of neo-antigen-reactive T(NRT) cells induced by RNA mutanome vaccine, which may serve as a feasible and effective therapeutic approach for lung cancer.

Methods: We predicted candidate neo-antigens according to the mutant gene analysis by sequencing the mouse Lewis cells and C57BL/6 mouse tail tissue. RNA vaccine was prepared with the neo-antigens as the template. We assessed antitumor efficacy, cytokine secretion and pathological changes after adoptive transfer of NRT cells in vitro and vivo experiments.

Results: We identified 10 non-synonymous somatic mutations and successfully generated NRT cells. The percentage of T-cell activation proportion was increased from 0.072% in conventional T cells to 9.96% in NRT cells. Interferon-γ secretion augmented from 17.8 to 24.2% as well. As an in vivo model, adoptive NRT cell infusion could promote active T-cell infiltration into the tumour tissue and could delay tumour progression.

Conclusion: NRT cells induced by RNA mutanome vaccine exert a significant anti-tumour effect in mouse lung cancer, and adoptive NRT cell therapy might be considered a feasible, effective therapeutic approach for lung cancer.
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http://dx.doi.org/10.1007/s00432-021-03735-yDOI Listing
July 2021

Evolutionary Insights Into Two Widespread Ectomycorrhizal Fungi () From Comparative Analysis of Mitochondrial Genomes.

Front Microbiol 2021 5;12:583129. Epub 2021 Jul 5.

Yunnan Plateau Characteristic Agricultural Industry Research Institute, Yunnan Agricultural University, Kunming, China.

The genus is a group of global ectomycorrhizal fungi. The characterizations of mitochondrial genomes have still been unknown. In the present study, the complete mitogenomes of two species, , and , were assembled and compared with other Boletales mitogenomes. Both mitogenomes comprised circular DNA molecules with sizes of 43,990 and 44,054 bp, respectively. Comparative mitogenomic analysis showed that the gene differentiated greatly between Boletales species, and this gene may be subjected to strong pressure of positive selection between some Boletales species. Several plasmid-derived genes and genes with unknown functions were detected in the two mitogenomes, which needs further analysis. The two species show a high degree of collinearity, which may represent the gene arrangement of the ancestors of ectomycorrhizal Boletales species. Frequent intron loss/gain events were detected in Boletales and basidiomycetes, and intron P717 was only detected in out of the eight Boletales mitogenomes tested. We reconstructed phylogeny of 79 basidiomycetes based on combined mitochondrial gene dataset, and obtained well-supported phylogenetic topologies. This study served as the first report on the mitogenomes of the family Pisolithaceae, which will promote the understanding of the evolution of species.
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http://dx.doi.org/10.3389/fmicb.2021.583129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287656PMC
July 2021

Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.

Cell Death Discov 2021 Jul 20;7(1):184. Epub 2021 Jul 20.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.

Studies of radiation interaction with tumor cells often take apoptosis as the desired results. However, mitotic catastrophe and senescence are also promoted by clinically relevant doses of radiation. Furthermore, p53 is a well-known transcription factor that is closely associated with radiosensitivity and radiation-induced cell death. Therefore, we aimed to investigate the involvement of radiosensitivity, cell death modalities and p53 status in response to carbon-ion radiation (CIR) here. Isogenic human colorectal cancer cell lines HCT116 (p53 and p53) were irradiated with high-LET carbon ions. Cell survival was determined by the standard colony-forming assay. 53BP1 foci were visualized to identify the repair kinetics of DNA double-strand breaks (DSBs). Cellular senescence was measured by SA-β-Gal and Ki67 staining. Mitotic catastrophe was determined with DAPI staining. Comparable radiosensitivities of p53 and p53 HCT116 colorectal cells induced by CIR were demonstrated, as well as persistent 53BP1 foci indicated DNA repair deficiency in both cell lines. Different degree of premature senescence in isogenic HCT116 colorectal cancer cells suggested that CIR-induced premature senescence was more dependent on p21 but not p53. Sustained upregulation of p21 played multifunctional roles in senescence enhancement and apoptosis inhibition in p53 cells. p21 inhibition further increased radiosensitivity of p53 cells. Complex cell death modalities rather than single cell death were induced in both p53 and p53 cells after 5 Gy CIR. Mitotic catastrophe was predominant in p53 cells due to inefficient activation of Chk1 and Chk2 phosphorylation in combination with p53 null. Senescence was the major cell death mechanism in p53 cells via p21-dependent pathway. Taken together, p21-mediated premature senescence might be used by tumor cells to escape from CIR-induced cytotoxicity, at least for a time.
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http://dx.doi.org/10.1038/s41420-021-00570-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292512PMC
July 2021

Endovascular treatment of symptomatic intracranial atherosclerotic stenosis with low profile visualized intraluminal support stent.

J Clin Neurosci 2021 Aug 17;90:256-261. Epub 2021 Jun 17.

Department of Neurosurgery, Changhai Hospital, Navy Military Medical University, Shanghai 200433, People's Republic of China.

Objective: Severe intracranial atherosclerotic stenosis has become one of the main causes resulting transient ischemic attack and stroke. This study aimed to evaluate the efficacy and safety of low profile visualized intraluminal support (LVIS) stent in treating symptomatic intracranial atherosclerotic stenosis.

Methods: Data of 31 patients with at least 70% stenosis treated with LVIS stent in our center were retrospectively collected between July 2017 and November 2020. Further evaluation of lesion characteristics, technical success rate, preoperative complication, clinical and angiographic follow-up outcome, delayed in-stent stenosis were conducted.

Results: Stent delivery and deployment were successfully achieved in all 31 patients (100%). 22 cases (71%) were located in anterior circulation and 9 cases (29%) were located in posterior circulation. The mean degree of stenosis lesion before stent deployment was 85.6 ± 9.4%, while after stenting was 11.2 ± 11.8%. One patient suffered from ischemic complication in stenting procedure, and timely delivery of rt-PA successfully recanalized the artery. Clinical follow-up was available in all 31patients (100%) with mean follow-up time 15.0 ± 12.1(3-45) months. No patients experienced the recurrence of stroke or TIA or death after discharge. Angiographic follow-up was available in 21patients (67.7%) with mean follow-up time 11.43 ± 6.8 (6-36) months. 19 patients (90.5%) were stable while 2 patients (9.5%) developed ISR in their last angiographic follow-up. The 2 patients received balloon angioplasty and reached satisfactory results after retreatment.

Conclusion: This preliminary study suggests that LVIS stent deployment was a feasible approach in treating intracranial atherosclerotic stenosis with satisfactory procedure success rate, low complication rate and favorable long-term outcome.
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http://dx.doi.org/10.1016/j.jocn.2021.06.009DOI Listing
August 2021

Transcriptome analysis reveals roles of polian vesicle in sea cucumber Apostichopus japonicus response to Vibrio splendidus infection.

Comp Biochem Physiol Part D Genomics Proteomics 2021 Jul 6;40:100877. Epub 2021 Jul 6.

Department of Ocean Technology, College of Marine and Biology Engineering, Yancheng Institute of Technology, Yancheng 224051, China. Electronic address:

Polian vesicle is originally regarded as a hematopoietic and inflammatory response organ in sea cucumber by the operations of cell depletion and heterogeneous cells injection, respectively. In the present study, to reveal the role and immune mechanisms of polian vesicle in response to pathogen, Vibrio splendidus, we first performed a comparative transcriptome analysis for the cells from polian vesicle wall in V. splendidus-challenged Apostichopus japonicus through RNA high-throughput sequencing technology. Briefly, 465,356,848 clean reads were obtained after cleaning up low-quality reads in total. Approximately 73% of the sequenced reads could be aligned to the reference genome of A. japonicus. The DEGs of CG (control group) vs TG 24 h (24 h post-infection group), CG vs TG 72 h (72 h post-infection group) and TG 24 h vs TG 72 h were 3762, 1391 and 3258, respectively. Gene Ontology (GO) annotation assay revealed that those genes associated with the processes such as cell process, cell, binding and catalytic activity were significantly induced in all three groups post V. splendidus infection. KEGG enrichment analysis suggested the DEGs in TG 24 h were enriched in Toll-like receptor (TLR) signaling pathway, complement and coagulation cascades, antigen processing and presentation and IL-17 signaling pathway compared with that in CG, while the pathways including ribosome biogenesis in eukaryotes, DNA replication, and cell cycle related with cell proliferation were mainly enriched in TG 72 h than that of CG. Furthermore, six important DEGs were chosen and showed the consistent expression patterns with the results of RNA-seq by qPCR. Overall, our analysis towards the current data demonstrates that polian vesicle may play an essential role in the regulation of immune response in A. japonicus and provide new insights into hematopoietic function of polian vesicle in response to pathogen infection.
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http://dx.doi.org/10.1016/j.cbd.2021.100877DOI Listing
July 2021

Angiogenesis-Related Immune Signatures Correlate With Prognosis, Tumor Microenvironment, and Therapeutic Sensitivity in Hepatocellular Carcinoma.

Front Mol Biosci 2021 28;8:690206. Epub 2021 Jun 28.

Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

Hepatocellular carcinoma (HCC) is one of the highly heterogeneous cancers that lacks an effective risk model for prognosis prediction. Therefore, we searched for angiogenesis-related immune genes that affected the prognosis of HCC to construct a risk model and studied the role of this model in HCC. In this study, we collected the transcriptome data of HCC from The Genome Atlas (TCGA) and the International Genome Consortium (ICGC) database. Pearson correlation analysis was performed to identify the association between immune genes and angiogenesis-related genes. Consensus clustering was applied to divide patients into clusters A and B. Subsequently, we studied the differentially expressed angiogenesis-related immune genes (DEari-genes) that affected the prognosis of HCC. The most significant features were identified by least absolute shrinkage and selection operator (LASSO) regression, and a risk model was constructed. The reliability of the risk model was evaluated in the TCGA discovery cohort and the ICGC validation cohort. In addition, we compared the novel risk model to the previous models based on ROC analysis. ssGSEA analysis was used for function evaluation, and pRRophetic was utilized to predict the sensitivity of administering chemotherapeutic agents. Cluster A patients had favorable survival rates. A total of 23 DEari-genes were correlated with the prognosis of HCC. A five-gene (including BIRC5, KITLG, PGF, SPP1, and SHC1) signature-based risk model was constructed. After regrouping the HCC patients by the median score, we could effectively discriminate between them based on the adverse survival outcome, the unique tumor immune microenvironment, and low chemosensitivity. The five-gene signature-based risk score established by ari-genes showed a promising clinical prediction value.
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http://dx.doi.org/10.3389/fmolb.2021.690206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273615PMC
June 2021

Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.

Int J Nanomedicine 2021 6;16:4661-4674. Epub 2021 Jul 6.

Institute of Modern Physics, Chinese Academy of Sciences; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, Gansu Province, 730000, People's Republic of China.

Purpose: Gold nanoparticles (AuNPs) are widely studied as radiosensitizers, but their radiosensitization in carbon ion radiotherapy is unsatisfactory. There is a lack of in vivo data on the radiosensitization of AuNPs under carbon ion irradiation. This study focused on the radiosensitization effect of AuNPs in the mouse melanoma cell line B16-F10 in vitro and in vivo.

Materials And Methods: 11-mercaptoundecanoic acid (11-MUA)-coated gold (Au) nanoparticles (mAuNPs) formulations were prepared and characterized. To verify the radiosensitization effect of mAuNPs, hydroxyl radicals were generated in aqueous solution, and the detection of intracellular reactive oxygen species (ROS) and clone survival were carried out in vitro. The tumor growth rate (TGR) and survival of mice were analyzed to verify the radiosensitization effect of mAuNPs in vivo. The apoptosis of tumor cells was detected, and the expression of key proteins in the apoptosis pathway was verified by immunohistochemistry.

Results: The intracellular ROS level in B16-F10 cells was enhanced by mAuNPs under carbon ion irradiation. The sensitization rate of mAuNPs was 1.22 with a 10% cell survival rate. Compared with irradiation alone, the inhibitory effect of mAuNPs combined with carbon ion irradiation on tumor growth was 1.94-fold higher, the survival time of mice was prolonged by 1.75-fold, and the number of apoptotic cells was increased by 1.43-fold. The ratio of key proteins Bax and Bcl2 in the apoptosis pathway was up-regulated, and the expression of caspase-3, a key executor of the apoptosis pathway, was up-regulated.

Conclusion: In in vivo and in vitro experiments, mAuNPs showed radiosensitivity to carbon ion irradiation. The sensitization effect of mAuNPs on mice tumor may be achieved by activating the mitochondrial apoptosis pathway and increasing tumor tissue apoptosis. To our best knowledge, the present study is the first in vivo evidence for radiosensitization of mAuNPs in tumor-bearing mice exposed to carbon ion irradiation.
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http://dx.doi.org/10.2147/IJN.S313678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275145PMC
July 2021

Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer.

Cancer Biol Med 2021 Jul 14. Epub 2021 Jul 14.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: To study the efficacy of the enhanced recovery after surgery (ERAS) program on postoperative recovery and complications in patients with gastric cancer.

Methods: Eighty patients in the perioperative period with radical gastrectomy were enrolled and randomly divided into 2 groups, the ERAS group and the non-ERAS group. The differences between the 2 groups in terms of postoperative recoveries and complications rate were determined. According to the body mass index (BMI) level, the ERAS group was divided into 2 subgroups, namely group A (BMI < 28 kg/m, = 16) and group B (BMI ≥ 28 kg/m, = 24). The non-ERAS group was also divided into group C (BMI < 28 kg/m, = 18) and group D (BMI ≥ 28 kg/m, = 22). The recovery and complications of each group were then determined.

Results: The postoperative length of stay and visual analogue scale pain score were less in the ERAS group than the non-ERAS group ( < 0.05). Time to first postoperative exhaustion, first postoperative defecation, returning leukocyte count to normal, and stopping intravenous nutrition were significantly shorter in the ERAS group ( = 40), compared to the non-ERAS group ( = 40, all < 0.05). The incidence of postoperative lower extremity intramuscular venous thrombosis was significantly higher in group D than in group B (χ = 4.800, = 0.028). In addition, the incidence of lower extremity intermuscular venous thrombosis and lung infection in group D was higher than those in other groups.

Conclusions: The perioperative ERAS program was associated with faster recovery in patients undergoing radical gastrectomy. For patients with higher BMI (BMI ≥ 28 kg/m), the use of the perioperative ERAS program was more advantageous.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0108DOI Listing
July 2021

The association between age at diagnosis of type 2 diabetes and albuminuria in Chinese adults: A nationwide population study.

J Diabetes 2021 Jul 14. Epub 2021 Jul 14.

Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.

Background: Type 2 diabetes is increasingly diagnosed at a younger age worldwide and in China. Limited data are available regarding the association between age at diabetes diagnosis and risks of albuminuria. This study sought to examine the independent effect of age at diagnosis of type 2 diabetes on the risk of albuminuria.

Methods: We used data from a nationwide multicenter study with 207 961 participants in mainland China. Age, sex, and study site were matched for 31 366 screen-detected type 2 diabetes cases and 31 366 normal controls. Age, sex, study site, and diabetes duration were matched for 7490 self-reported type 2 diabetes cases and 7490 normal controls. Risks of having albuminuria in matched type 2 diabetes vs controls were examined using multivariable logistic regression analysis in strata of age at diabetes diagnosis.

Results: Although the absolute rate of albuminuria is higher in older adults, the odds ratio of albuminuria in type 2 diabetes vs matched controls decreased with increasing age at diagnosis. For participants with diabetes diagnosed at an age of <50, 50 to 59, 60 to 69, or ≥70 years, the multivariable adjusted risk of albuminuria increased by 81%, 60%, 45%, and 33% for screen-detected diabetes, and 135%, 121%, 90%, and 58% for self-reported diabetes compared with their normal controls, respectively.

Conclusions: A younger age at diagnosis of type 2 diabetes is associated with a more significantly elevated risk of albuminuria than an older age at diagnosis in Chinese adults.
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http://dx.doi.org/10.1111/1753-0407.13213DOI Listing
July 2021

Phototunable Lignin Plastics to Enable Recyclability.

ChemSusChem 2021 Jul 13. Epub 2021 Jul 13.

Texas A&M University, Department of Plant Pathology and Microbiology, 2132 TAMU, 77843, College Station, UNITED STATES.

The accumulation of non-degradable petrochemical plastics imposed a significant threat to the environment and ecosystems. We hereby addressed this challenge by designing a new type of phototunable plastics based on the unique lignin chemistry to enable readily end-life recycling. The advanced material design leveraged the efficient photocatalytic lignin depolymerization by zinc oxide nanoparticles to build lignin-PMMA-ZnO blends and composite. We first demonstrated the highly effective phototunable lignin depolymerization in the complex polymer blend matrix and explored the molecular mechanisms. The technical barriers of mechanical property and recycling processing were then addressed by the design of composite with lignin core grafted with PMMA polymer. The new process has resulted in a new type of PMMA- g -lignin composite which significantly improved the mechanical properties, making it comparable to PMMA alone. More importantly, the mechanical properties of the ultraviolet (UV)-treated composite decreased drastically in the new design, whereas the properties did not reduce in the non-grafted blends upon UV exposure. The results highlighted that the new composite design based on graftization maximized the impact of lignin depolymerization on composite structure and recyclability. Based on the results, we developed a process integrating UV and alkaline treatments to recycle PMMA for plastics and fractionated lignin for bioconversion or other applications in the new phototunable plastics.
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http://dx.doi.org/10.1002/cssc.202101040DOI Listing
July 2021

Predictive value of creatine kinase MB for contrast-induced acute kidney injury among myocardial infarction patients.

BMC Cardiovasc Disord 2021 Jul 13;21(1):337. Epub 2021 Jul 13.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Background: Predictive value of creatine kinase MB (CK-MB) for contrast-induced acute kidney injury (CI-AKI) among myocardial infarction (MI) patients has rarely been reported. We aim to evaluate the predictive value of CK-MB for CI-AKI among MI patients.

Methods: Totally, 1131 MI patients were included from the REduction of rIsk for Contrast-Induced Nephropathy (REICIN) study. The peak CK-MB before coronary angiography (CAG) was chosen. The study population was divided into two groups by log-transformed CK-MB cut-off point. The association between CK-MB and CI-AKI was tested by multivariable logistic regression. CK-MB was integrated with Age, creatinine and ejection fraction (ACEF) score and Mehran risk score (MRS) to evaluate the additive value of CK-MB. The integrated models were validated internally by the bootstrap method and externally by the PREdictive Value of COntrast voluMe to creatinine Clearance Ratio (PRECOMIN) study data set.

Results: Overall, 62(5.48%) patients developed CI-AKI, patients with CK-MB point > 4.7 displayed a higher incidence of CI-AKI than those without (11.9% vs. 4.0%, p < 0.001). CK-MB point > 4.7 was independently associated with CI-AKI (adjusted OR: 3.40, 95% CI: 1.93-5.98, p < 0.001). The additions of CK-MB to ACEF score, Mehran score A and Mehran score B resulted in increases in C-statistics, which ranged from 0.680 to 0.733 (p = 0.046), 0.694 to 0.727 (p = 0.091), 0.704 to 0.734 (p = 0.102), respectively. Internal validation also showed increases in C-statistics, and external validation performed well in discrimination and calibration.

Conclusions: Preprocedural peak CK-MB was a predictor of CI-AKI among MI patients.
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http://dx.doi.org/10.1186/s12872-021-02155-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276394PMC
July 2021

Rapid identification of a stripe rust resistance gene YrXK in Chinese wheat line Xike01015 using specific locus amplified fragment (SLAF) sequencing.

Plant Dis 2021 Jul 12. Epub 2021 Jul 12.

Southwest University, College of Plant Protection, No.2, Tiansheng Street, Beibei District, Chongqing, China, 400715;

Wheat stripe rust, an airborne fungal disease and caused by Puccinia striiformis Westend. f. sp. tritici (Pst), is one of the most devastating diseases on wheat. It is the most effective and economical measure for the diseases control to identify high-level resistance genes and apply in wheat breeding. Chinese wheat cultivar Xike01015 presents high levels of all stage resistance (ASR) to the current predominant Pst race CYR33. In this study, a single dominant gene, designated as YrXk, was identified in Xike01015 conferring resistance to CYR33 with genetic analysis of F2 and BC1 population from cross of Mingxian169 (susceptible) and Xike01015. The specific length amplified fragment sequencing (SLAF-seq) strategy was used to construct linkage map in the F2 population. QTL analysis mapped YrXk to a 12.4 Mb segment on chromosome1BS, explaining over 86.96% phenotypic variance. Gene annotation in the QTL region identified three differential expressed candidate genes , TraesCS1B02G168600.1, TraesCS1B02G170200.1, and TraesCS1B02G172400.1. The qRT-PCR results displayed that TraesCS1B02G170200.1 and TraesCS1B02G168600.1 significantly up-regulated and down-regulated, respectively, and TraesCS1B02G170200.1 slightly up-regulated after changed with CYR33 in the seedling stage, which indicating these genes may function in wheat resistance to stripe rust. The results of this study can be used in wheat breeding for improving resistance to stripe rust.
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http://dx.doi.org/10.1094/PDIS-12-20-2648-REDOI Listing
July 2021

Two-Dimensional Quantum Hall Effect and Zero Energy State in Few-Layer ZrTe.

Nano Lett 2021 Jul 12;21(14):5998-6004. Epub 2021 Jul 12.

Max Planck Institute for Solid State Research, Stuttgart 70569, Germany.

Topological matter plays a central role in today's condensed matter research. Zirconium pentatelluride (ZrTe) has attracted attention as a Dirac semimetal at the boundary of weak and strong topological insulators (TI). Few-layer ZrTe is anticipated to exhibit the quantum spin Hall effect due to topological states inside the band gap, but sample degradation inflicted by ambient conditions and processing has so far hampered the fabrication of high quality devices. The quantum Hall effect (QHE), serving as the litmus test for 2D systems to be considered of high quality, has not been observed so far. Only a 3D variant on bulk was reported. Here, we succeeded in preserving the intrinsic properties of thin films lifting the carrier mobility to ∼3500 cm V s, sufficient to observe the integer QHE and a bulk band gap related zero-energy state. The magneto-transport results offer evidence for the gapless topological states within this gap.
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http://dx.doi.org/10.1021/acs.nanolett.1c00958DOI Listing
July 2021

Activation of Glucagon-Like Peptide-1 Receptor Ameliorates Cognitive Decline in Type 2 Diabetes Mellitus Through a Metabolism-Independent Pathway.

J Am Heart Assoc 2021 Jul 10;10(14):e020734. Epub 2021 Jul 10.

Center for Hypertension and Metabolic Diseases Department of Hypertension and Endocrinology Daping Hospital Army Medical University Chongqing China.

Background Patients with hypertension and diabetes mellitus are susceptible to dementia, but regular therapy fails to reduce the risk of dementia. Glucagon-like peptide-1 receptor agonists have neuroprotective effects in experimental studies. We aimed to assess the effect of liraglutide, a glucagon-like peptide-1 receptor agonist, on cognitive function and whether its effect was associated with metabolic changes in patients with type 2 diabetes mellitus. Methods and Results Fifty patients with type 2 diabetes mellitus were recruited in this prospective study. All patients underwent cognitive assessment and brain activation monitoring by functional near-infrared spectroscopy. At 12 weeks, patients in the glucagon-like peptide-1 group acquired better scores in all cognitive tests and showed remarkable improvement in memory and attention (=0.040) test compared with the control group after multivariable adjustment. Compared with the control group, liraglutide significantly increased activation of the dorsolateral prefrontal cortex and orbitofrontal cortex brain regions (=0.0038). After liraglutide treatment, cognitive scores were significantly correlated with changes in these activating brain regions (<0.05), but no correlation was observed between the changes in cognitive function and changes of body mass index, blood pressure, and glycemic levels. Conclusions We concluded that liraglutide improves cognitive decline in patients with type 2 diabetes mellitus. This beneficial effect is independent of its hypoglycemic effect and weight loss. The optimal intervention should be targeted to cognitive decline in the early stages of dementia. Registration URL: https://www.ClinicalTrials.gov; Unique identifier: NCT03707171.
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http://dx.doi.org/10.1161/JAHA.120.020734DOI Listing
July 2021

A method to identify patients with severe COVID-19.

Asian J Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Liver Cirrhosis, Jinan Infectious Disease Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Shandong Public Health Clinical Center, Jinan, Shandong, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2021.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220991PMC
June 2021

The role of oxidative stress in the susceptibility of noise-impaired cochleae to synaptic loss induced by intracochlear electrical stimulation.

Neuropharmacology 2021 Jul 8;196:108707. Epub 2021 Jul 8.

Department of Otolaryngology - Head and Neck Surgery, Eye & ENT Hospital of Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Hearing Medicine, Shanghai, China. Electronic address:

Intracochlear electrical stimulation (ES) generated by cochlear implants (CIs) is used to activate auditory nerves to restore hearing perception in deaf subjects and those with residual hearing who use electroacoustic stimulation (EAS) technology. Approximately 1/3 of EAS recipients experience loss of residual hearing a few months after ES activation, but the underlying mechanism is unknown. Clinical evidence indicates that the loss is related to the previous history of noise-induced hearing loss (NIHL). In this report, we investigated the impact of intracochlear ES on oxidative stress levels and synaptic counts in inner hair cells (IHCs) of the apical, middle and basal regions of guinea pigs with normal hearing (NH) and NIHL. Our results demonstrated that intracochlear ES with an intensity of 6 dB above the thresholds of electrically evoked compound action potentials (ECAPs) could induce the elevation of oxidative stress levels, resulting in a loss of IHC synapses near the electrodes in the basal and middle regions of the NH cochleae. Furthermore, the apical region of cochleae with NIHL were more susceptible to synaptic loss induced by relatively low-intensity ES than that of NH cochleae, resulting from the additional elevation of oxidative stress levels and the reduced antioxidant capability throughout the whole cochlea.
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http://dx.doi.org/10.1016/j.neuropharm.2021.108707DOI Listing
July 2021

Effectiveness of a coordinated support system linking public hospitals to a health coaching service compared with usual care at discharge for patients with chronic low back pain: protocol for a randomised controlled trial.

BMC Musculoskelet Disord 2021 Jul 9;22(1):611. Epub 2021 Jul 9.

The University of Sydney, Faculty of Medicine and Health, Sydney, NSW, Australia.

Background: Although many people with chronic low back pain (LBP) improve following conservative treatment, one in five will experience worsening symptoms after discharge from treatment and seek health care again. The current LBP clinical care pathway in many health services lacks a well-integrated, systematic approach to support patients to remain physically active and self-manage their symptoms following discharge from treatment. Health coaching can support people to improve physical activity levels and may potentially reduce health care utilisation for LBP. The primary aim of this study is to evaluate the effect of introducing a coordinated support system (linking hospital outpatient physiotherapy services to a public health coaching service) at discharge from LBP treatment, on the future use of hospital, medical, and health services for LBP, compared with usual care provided at discharge.

Methods: Three hundred and seventy-four adults with chronic non-specific LBP will be recruited from the outpatient physiotherapy departments of public hospitals in New South Wales, Australia. Participants will be individually randomised to a support system (n = 187) or usual care group (n = 187). All participants will receive usual care provided at discharge from treatment. Participants allocated to the support system will also receive up to 10 telephone-based health coaching sessions, delivered by the Get Healthy Service®, over a 6-month period. Health coaches will monitor and support participants to improve physical activity levels and achieve personal health-related goals. The primary outcome is the total number of encounters with hospital, medical, and health services for LBP, at 12 months from baseline. A within-trial economic evaluation will quantify the incremental costs and benefits of the support system from a health system perspective, to support reimbursement decision making.

Discussion: This study will establish the effect of a coordinated support system, introduced at discharge from treatment, on the future use of hospital, medical, and health services for LBP and various health outcomes.

Conclusion: Innovative community-driven solutions to support people with chronic LBP after discharge from treatment are urgently needed. Study findings will help inform health care policy and clinical practice in Australia.

Trial Registration: Prospectively registered on the Australian New Zealand Clinical Trials Registry ( ACTRN12620000889954 ) on 10/09/2020.
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http://dx.doi.org/10.1186/s12891-021-04479-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272287PMC
July 2021

Feasibility of nuclide-identified imaging based on the back-streaming white neutron beam at the China Spallation Neutron Source.

Rev Sci Instrum 2021 May;92(5):053303

Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China.

Back-streaming neutrons through the incoming proton channel at the spallation target station of the China Spallation Neutron Source have been studied as a white neutron source (Back-n). We report a physical study on white neutron imaging based on the Back-n beamline. The wide neutron energy spectrum spanning from 1 eV to 100 MeV was very suitable for nuclide-identified imaging as well as measurements of nuclear data and other applications. We calculated the back-streaming white neutron energy spectrum using the Monte Carlo N-Particle code. A comparison of the results of calculation with those of the FLUktuierende KAskade code and experimental measurements were carried out. The energy resolution of the Back-n beam was close to 5% depending on the neutron energy and the modes of operation, and its spatial resolution could attain the order of tens of micrometers.
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http://dx.doi.org/10.1063/5.0040767DOI Listing
May 2021

Promoting the conversion of CO to CHvia synergistic dual active sites.

Nanoscale 2021 Jul 9;13(28):12233-12241. Epub 2021 Jul 9.

School of Physics, Southeast University, Nanjing, 211189, China.

Carbon-based single-atom catalysts (SACs) have shown promising applications in the conversion of CO into CO. However, the deep reduction process for the production of high-value hydrocarbons is largely limited due to the weak activation of CO. Herein, on the basis of first-principles calculations, a simple coordination regulation method of the active site is proposed to improve the conversion of CO. Taking NiN as an example, by introducing heteroatoms (B, C, O, P, and S atoms), we reveal that NiNB can effectively capture *CO and further convert to CH with an ultralow limiting potential of -0.42 V. The excellent catalytic performance is probably attributed to the formed synergistic dual active sites between non-metal B and metal Ni atoms. Moreover, NiNB can maintain good stability and the catalytic performance can be further enhanced by increasing the B-doping concentration. This work demonstrates that coordination regulation is an effective strategy to improve the performance of single-atom catalysts and paves a possible way to advance the development of non-Cu-based CORR electrocatalysts for high-value hydrocarbon products.
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http://dx.doi.org/10.1039/d1nr02582aDOI Listing
July 2021
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