Publications by authors named "Qiang Gao"

820 Publications

Direct Epitaxial Growth of Nickel Phosphide Nanosheets on Nickel Foam as Self-support Electrode for Efficient Non-enzymatic Glucose Sensing.

Nanotechnology 2021 Jul 20. Epub 2021 Jul 20.

China University of Geosciences Faculty of Materials Science and Chemistry, 68 Jincheng Street, East Lake High-tech Development Zone, Wuhan 430074, P. R. China, Wuhan, Hubei, 430074, CHINA.

Design and develop of cost-effective non-enzymatic electrode materials is of great importance for next generation of glucose sensors. In this work, we report a high-performance self-supporting electrode fabricated via direct epitaxial growth of nickel phosphide on Ni foam (Ni2P/NF) for nonenzymatic glucose sensors in alkaline solution. Under the optimal conditions, the uniform Ni2P nanosheets could be obtained with an average thickness of 80 nm, which provides sufficient active sites for glucose molecules. As a consequence, the Ni2P/NF electrode displays superior electrochemistry performances with a high sensitivity of 6375.1 μA mM-1 cm-2, a quick response about 1 s, a low detection limit of 0.14 μM (S/N = 3), and good selectivity and specificity. Benefit from the strong interaction between Ni2P and NF, the Ni2P/NF electrode is also highly stable for long-term applications. Furthermore, the Ni2P/NF electrode is capable of analyzing glucose in human blood serum with satisfactory results, indicating that the Ni2P/NF is a potential candidate for glucose sensing in real life.
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http://dx.doi.org/10.1088/1361-6528/ac162fDOI Listing
July 2021

Uncovering the mechanism of the Shenzhi Jiannao formula against vascular dementia using a combined network pharmacology approach and molecular biology.

Phytomedicine 2021 Jun 24;90:153637. Epub 2021 Jun 24.

Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: Shenzhi Jiannao formula (SZJNF) is a herbal prescription which is used for detoxification, dredging collaterals, and activating blood circulation and Qi flow in traditional Chinese medicine. SZJNF is a clinical effective prescription for the treatment of vascular dementia (VD) first formulated based on the classical theory of traditional Chinese medicine, but its anti-VD mechanism remains ambiguous.

Purpose: The aim of this study was to elucidate the multi-target mechanisms of SZJNF against VD using a network pharmacology approach and verify its effects through biological experiments.

Study Design And Methods: We utilized network pharmacology-based prediction and molecular docking techniques to uncover the potential micro-mechanism of SZJNF against VD. We identified active components and potential targets, and performed network analysis, functional annotation, and pathway enrichment analysis. Subsequently, glutamate-induced PC12 cells and VD rats were used to verify the molecular mechanisms of SZJNF.

Results: Seventeen active compounds were identified in SZJNF rat plasma; moreover, 773 predicted targets and 1544 VD-related targets were found. Various networks, including the PPI, herb-compound-target, and compound-target-pathway network were constructed. A total of 188 shared targets were identified by network topological analysis, which were closely associated to the anti-VD effects of SZJNF. They were also enriched in various biological processes through hypoxia reaction, promotion of cell proliferation, inhibition of apoptosis, neuroactive ligand-receptor interaction, and calcium signaling pathway, as evaluated by the analysis of advanced functions and pathways. SZJNF components docked well with the key targets. Treatment with SZJNF promoted cell proliferation, ameliorated apoptosis and oxidative stress injury, and improved neurological and cognitive abilities.

Conclusion: This study comprehensively demonstrated the multi-target mechanisms of SZJNF in VD using network pharmacology and molecular biology experiments. This provides evidence for further mechanistic studies and for the development of SZJNF as a potential treatment for patients with VD.
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http://dx.doi.org/10.1016/j.phymed.2021.153637DOI Listing
June 2021

Smoking induces the occurrence of colorectal cancer via changing the intestinal permeability.

J BUON 2021 May-Jun;26(3):1009-1015

Department of Hepatobiliary Surgery, Baogang Hospital, Baogang, China.

Purpose: Colorectal cancer (CRC) is the third most frequent cancer. Its occurrence is closely linked to lifestyle and diet habits, such as excessive intake of high-fat food, but their impact on CRC, however, remain unclear.

Methods: Eligible CRC patients were retrospectively analyzed. Overall survival (OS) and recurrence-free survival (RFS) in smokers and non-smokers of CRC patients were assessed. APCmin/+ mice were exposed to cigarette smoking, followed by detection of CRC growth and intestinal permeability.

Results: A total of 416 eligible CRC patients were recruited, involving 218 (52.4%) smokers and 198 (47.6%) non-smokers. OS was shorter in CRC smokers than in non-smokers (p=0.005), whereas smoking did not affect RFS in CRC patients (p=0.251). Cigarette smoking increased CRC tumor numbers of CRC in APCmin/+ mice. Proliferation and apoptosis of colorectal epithelial cells, and inflammatory response in mice were changed following smoking. Notably, the treatment of probiotics mixture VSL#3 decreased the number of CRC tissues and intestinal permeability in APCmin/+ mice exposed to cigarette smoking.

Conclusions: Smoking increases the susceptibility to CRC through damaging the intestinal permeability. Protecting the intestinal permeability significantly protects intestinal tracts.
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July 2021

Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study.

Evid Based Complement Alternat Med 2021 23;2021:5516525. Epub 2021 Jun 23.

Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.

Background: Depression is a common mental disease that lacks effective therapeutic drugs with good curative effects and few adverse reactions. Traditional Chinese medicine (TCM) has the advantages of multiple components, multiple channels, and fewer adverse reactions in the treatment of depression. Although Xingpi Jieyu Decoction (XPJYD) demonstrates a good therapeutic effect on depression, the pharmacological mechanism underlying its antidepressant effect is still unclear.

Methods: We used a network pharmacology strategy, including the construction and analysis of a complex drug-disease network, to explore the complex mechanism of XPJYD treatment of depression. In addition, molecular docking technology was used to preliminarily study the binding ability of the potential active components and core therapeutic targets of XPJYD.

Results: The network pharmacology results showed 42 targets of XPJYD that are involved in depression. PPI network analysis demonstrated that the top 10 core targets were AKT1, VEGFA, MAPK8, FOS, ESR1, NR3C1, IL6, HIF1A, NOS3, and AR. The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal·mol, indicating a good docking effect. The GO enrichment analysis results showed that the XPJYD antidepression mechanism mainly involves the following biological processes such as apoptotic signaling pathway, cellular response to lipid, inflammatory response, and others. The KEGG analysis results indicated that XPJYD may regulate 13 pathways such as PI3K-Akt signaling pathway and estrogen signaling pathway in the treatment of depression.

Conclusions: This study reflects the characteristics of the mechanism of action by which XPJYD treats depression, which includes multiple components, multiple targets, and multiple pathways, and provides a biological basis for further verification and a novel perspective for drug discovery in depression.
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http://dx.doi.org/10.1155/2021/5516525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249129PMC
June 2021

Serum pepsinogen II levels are doubled with Helicobacter pylori infection in an asymptomatic population of 40,383 Chinese subjects.

Medicine (Baltimore) 2021 Jul;100(27):e26562

Department of Gastroenterology and Hepatology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.

Abstract: Pepsinogen (PG) I and II are crucial in the gastric digestive processes. This study is to examine the relationship of serum PGI, PGII, and PGI/PGII ratio with Helicobacter pylori (Hp) infection, age, sex, and body mass index (BMI) in subjects in Beijing, China.A total of 40,383 asymptomatic subjects, who underwent medical examination in Beijing Rehabilitation Hospital, were included in this study. Serum PG levels were measured using chemoluminescence techniques. The age, sex, and BMI data were collected, and Hp infection was identified with 13C-urea breath test. Statistical analysis was conducted with Python, Pandas and Seaborn software.Asymptomatic subjects with Hp infection (Hp+) had a significantly higher level of PGI in the serum (111 ng/mL [median]) than those without Hp infection (Hp-) (94 ng/mL, P < .001). The asymptomatic Hp+ subjects had 2-fold higher PGII levels (7.2 ng/mL) than Hp- subjects (3.2 ng/mL, P < .001). These changes produced significantly lower PGI/II ratio in Hp+ patients than in Hp- subjects (16:30, P < .001). The serum PGI and PGII levels were higher in males than in females (PGI: 104 ng/mL vs 95 ng/mL, PGII: 4.3 ng/mL vs 3.7 ng/mL, both P < .001), PGI/II ratio of males is at 95% of that in females (P < .001). PGI and PGII levels gradually increased in older people (P < .001), whereas the PGI/II ratio decreased significantly with age (P < .001). The levels of the two serum PGs were decreased and the ratio increased when BMI were higher than 28 kg/cm2 (P < .05).The levels of serum PGI, especial PGII, were increased by Hp infection, and also influenced by age, sex, and BMI. Therefore, these influencing factors should be considered during clinical practice.
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http://dx.doi.org/10.1097/MD.0000000000026562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270603PMC
July 2021

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial.

Lancet Infect Dis 2021 Jun 28. Epub 2021 Jun 28.

Sinovac Life Sciences, Beijing, China. Electronic address:

Background: A vaccine against SARS-CoV-2 for children and adolescents will play an important role in curbing the COVID-19 pandemic. Here we aimed to assess the safety, tolerability, and immunogenicity of a candidate COVID-19 vaccine, CoronaVac, containing inactivated SARS-CoV-2, in children and adolescents aged 3-17 years.

Methods: We did a double-blind, randomised, controlled, phase 1/2 clinical trial of CoronaVac in healthy children and adolescents aged 3-17 years old at Hebei Provincial Center for Disease Control and Prevention in Zanhuang (Hebei, China). Individuals with SARS-CoV-2 exposure or infection history were excluded. Vaccine (in 0·5 mL aluminum hydroxide adjuvant) or aluminum hydroxide only (alum only, control) was given by intramuscular injection in two doses (day 0 and day 28). We did a phase 1 trial in 72 participants with an age de-escalation in three groups and dose-escalation in two blocks (1·5 μg or 3·0 μg per injection). Within each block, participants were randomly assigned (3:1) by means of block randomisation to receive CoronaVac or alum only. In phase 2, participants were randomly assigned (2:2:1) by means of block randomisation to receive either CoronaVac at 1·5 μg or 3·0 μg per dose, or alum only. All participants, investigators, and laboratory staff were masked to group allocation. The primary safety endpoint was adverse reactions within 28 days after each injection in all participants who received at least one dose. The primary immunogenicity endpoint assessed in the per-protocol population was seroconversion rate of neutralising antibody to live SARS-CoV-2 at 28 days after the second injection. This study is ongoing and is registered with ClinicalTrials.gov, NCT04551547.

Findings: Between Oct 31, 2020, and Dec 2, 2020, 72 participants were enrolled in phase 1, and between Dec 12, 2020, and Dec 30, 2020, 480 participants were enrolled in phase 2. 550 participants received at least one dose of vaccine or alum only (n=71 for phase 1 and n=479 for phase 2; safety population). In the combined safety profile of phase 1 and phase 2, any adverse reactions within 28 days after injection occurred in 56 (26%) of 219 participants in the 1·5 μg group, 63 (29%) of 217 in the 3·0 μg group, and 27 (24%) of 114 in the alum-only group, without significant difference (p=0·55). Most adverse reactions were mild and moderate in severity. Injection site pain was the most frequently reported event (73 [13%] of 550 participants), occurring in 36 (16%) of 219 participants in the 1·5 μg group, 35 (16%) of 217 in the 3·0 μg group, and two (2%) in the alum-only group. As of June 12, 2021, only one serious adverse event of pneumonia has been reported in the alum-only group, which was considered unrelated to vaccination. In phase 1, seroconversion of neutralising antibody after the second dose was observed in 27 of 27 participants (100·0% [95% CI 87·2-100·0]) in the 1·5 μg group and 26 of 26 participants (100·0% [86·8-100·0]) in the 3·0 μg group, with the geometric mean titres of 55·0 (95% CI 38·9-77·9) and 117·4 (87·8-157·0). In phase 2, seroconversion was seen in 180 of 186 participants (96·8% [93·1-98·8]) in the 1·5 μg group and 180 of 180 participants (100·0% [98·0-100·0]) in the 3·0 μg group, with the geometric mean titres of 86·4 (73·9-101·0) and 142·2 (124·7-162·1). There were no detectable antibody responses in the alum-only groups.

Interpretation: CoronaVac was well tolerated and safe and induced humoral responses in children and adolescents aged 3-17 years. Neutralising antibody titres induced by the 3·0 μg dose were higher than those of the 1·5 μg dose. The results support the use of 3·0 μg dose with a two-immunisation schedule for further studies in children and adolescents.

Funding: The Chinese National Key Research and Development Program and the Beijing Science and Technology Program.
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http://dx.doi.org/10.1016/S1473-3099(21)00319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238449PMC
June 2021

Genetic diversity and evolutionary patterns of Rodin.

Ecol Evol 2021 Jun 7;11(12):7917-7926. Epub 2021 May 7.

State Key Laboratory of Cotton Biology Institute of Cotton Research Chinese Academy of Agricultural Sciences Anyang China.

Rodin (TKS) is an important potential alternative source of natural inulin and rubber production, which has great significance for the production of industrial products. In this study, we sequenced 58 wild TKS individuals collected from four different geography regions worldwide to elucidate the population structure, genetic diversity, and the patterns of evolution. Also, the first flowering time, crown diameter, morphological characteristics of leaf, and scape of all TKS individuals were measured and evaluated statistically. Phylogenetic analysis based on SNPs and cluster analysis based on agronomic traits showed that all 58 TKS individuals could be roughly divided into three distinct groups: (a) Zhaosu County in Xinjiang (population AB, including a few individuals from population C and D); (b) Tekes County in Xinjiang (population C); and (c) Tuzkol lake in Kazakhstan (population D). Population D exhibited a closer genetic relationship with population C compared with population AB. Genetic diversity analysis further revealed that population expansion from C and D to AB occurred, as well as gene flow between them. Additionally, some natural selection regions were identified in AB population. Function annotation of candidate genes identified in these regions revealed that they mainly participated in biological regulation processes, such as transporter activity, structural molecule activity, and molecular function regulator. We speculated that the genes identified in selective sweep regions may contribute to TKS adaptation to the Yili River Valley of Xinjiang. In general, this study provides new insights in clarifying population structure and genetic diversity analysis of TKS using SNP molecular markers and agronomic traits.
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http://dx.doi.org/10.1002/ece3.7622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216896PMC
June 2021

Investigating of deaf emotion cognition pattern by EEG and facial expression combination.

IEEE J Biomed Health Inform 2021 Jun 25;PP. Epub 2021 Jun 25.

With the development of sensor technology and learning algorithms, multimodal emotion recognition has attracted widespread attention. Many existing studies on emotion recognition mainly focused on normal people. Besides, due to hearing loss, deaf people cannot express emotions by words, which may have a greater need for emotion recognition. In this paper, the deep belief network (DBN) was utilized to classify three category emotions through the electroencephalograph (EEG) and facial expressions. Signals from 15 deaf subjects were recorded when they watched the emotional movie clips. Our system uses a 1-s window without overlap to segment the EEG signals in five frequency bands, then the differential entropy (DE) feature is extracted. The DE feature of EEG and facial expression images plays as multimodal input for subject-dependent emotion recognition. To avoid feature redundancy, the top 12 major EEG electrode channels (FP2, FP1, FT7, FPZ, F7, T8, F8, CB2, CB1, FT8, T7, TP8) in the gamma band and 30 facial expression features (the areas around the eyes and eyebrow) which are selected by the largest weight values. The results show that the classification accuracy is 99.92% by feature selection in deaf emotion reignition. Moreover, investigations on brain activities reveal deaf brain activity changes mainly in the beta and gamma bands, and the brain regions that are affected by emotions are mainly distributed in the prefrontal and outer temporal lobes.
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http://dx.doi.org/10.1109/JBHI.2021.3092412DOI Listing
June 2021

Environmental change and fishermen's income: is there a poverty trap : Evidence from China's coastal areas.

Environ Sci Pollut Res Int 2021 Jun 23. Epub 2021 Jun 23.

College of Management, Ocean University of China, No.238 Songling Rd, Qingdao, 266100, Shandong, China.

The unequal cost and benefit led by environmental changes may potentially set China's rural areas a "Poverty Trap." Therefore, clarifying the relationship between environmental changes and rural income distribution is of great significance to realize the organic integration of environmental improvement and poverty governance. Based on the panel data of China's coastal areas, this paper explores the mutual influence between environmental changes and fishermen's income distribution, thus testing the hypothesis of the poverty-environment trap. The results show that environmental degradation has a significant negative impact on fishermen's income. To be specific, compared with the middle- and high-income groups, the impact of environmental degradation on people with less income is more noticeable; as for the low-income groups represented by fishermen, the marginal effects of their income reduction on environmental degradation are more prominent; continuous decrease of their income together with environmental deterioration will form a vicious circle, bringing the risk of falling into the poverty-environment trap. In the follow-up environmental governance, authorities need to impose targeted measures and adopt tax or subsidy policies that are inclusive and preferential, so as to address the income gaps between fishermen and further relative poverty.
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http://dx.doi.org/10.1007/s11356-021-14254-1DOI Listing
June 2021

16S rRNA Gene Amplicon Sequencing of Gut Microbiota from Naked Carp (Gymnocypris przewalskii) in Qinghai Lake, China.

Microbiol Resour Announc 2021 Jun 10;10(23):e0037421. Epub 2021 Jun 10.

State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China.

Naked carp (Gymnocypris przewalskii) is a second-grade animal under state protection of China. We report 16S rRNA gene amplicon analysis of the gut microbiota of Gymnocypris przewalskii. The three most abundant phyla are , , and , and the six most abundant genera are , , , , , and .
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http://dx.doi.org/10.1128/MRA.00374-21DOI Listing
June 2021

Maternal and environmental microbes dominate offspring microbial colonization in the giant freshwater prawn Macrobrachium rosenbergii.

Sci Total Environ 2021 May 27;790:148062. Epub 2021 May 27.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.

Microbial colonization is vital for physiological equilibrium in animals. However, the impact of maternal and environmental microbes on microbial succession in the early developmental stages of Macrobrachium rosenbergii remains elusive. In this study, the effects of maternal and environmental microbes on the embryonic and larval microbiota of M. rosenbergii were evaluated by high-throughput sequencing. The results showed that Proteobacteria and Firmicutes were the dominant phyla in the intestine, gonads, and hepatopancreases of maternal prawn. In addition, Actinobacteria was dominant in the intestine while Actinobacteria, Bacteroidetes, and Acidobacteria were dominant in gonads of maternal prawn. During the embryonic stages, Proteobacteria, Actinobacteria, and Bacteroidetes became the dominant phyla. In post-larval stages, Proteobacteria, Actinobacteria, Firmicutes, and Bacteroidetes tended to dominate. In the water, Proteobacteria, Actinobacteria, and Bacteroidetes were the dominant phyla at 7, 14, and 21 dph water. Maternal microbes prominently impacted the microbial composition during the embryonic stages. Specifically, microbial colonization during embryonic stages was directly related to the maternal hepatopancreas according to source-tracking models. When the post-larvae developed to 7 days, the high contribution to the larval microbiota mimicked the environment. These results indicated that microbial colonization in embryonic and post-larval stages was attributed to the maternal and environmental microbe community, respectively. This study provides a theoretical basis for microbial community manipulation to promote prawn growth and physiological health in aquaculture.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148062DOI Listing
May 2021

Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/β-catenin signaling following ischemic stroke.

CNS Neurosci Ther 2021 May 31. Epub 2021 May 31.

Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Endothelial canonical (Wnt/β-catenin) and non-canonical Wnt signalings (Wnt/PCP and Wnt/Ca ) promote blood-brain barrier (BBB) development and antagonize each other. However, the effects of ischemic stroke on endothelial canonical and non-canonical Wnt signalings are unclear. Further, how non-canonical Wnt signalings are influenced by upregulation of endothelial Wnt/β-catenin signaling and subsequently affect BBB function following ischemic stroke have not been studied.

Methods: First, we determined the levels of Wnt signaling markers including TCF/LEF1 transcription activity, Axin2 mRNA, phospho-JNK , and NFAT in brain endothelial cells (ECs) with the deletion of Wnt receptor Frizzled (Fzd)4 or Fzd6, the two most abundant Fzds in brain ECs. Next, we observed the effect of ischemia/reperfusion injury on Wnt signalings in brain ECs and adult mice. Last, we assessed the changes of non-canonical Wnt signalings and BBB injury in the early stage of ischemic stroke in mice with endothelial β-catenin activation (β-cat mice).

Results: Fzd4 or Fzd6 deletion dampened both Wnt/β-catenin and Wnt/PCP signalings but enhanced Wnt/Ca signaling in brain ECs. Both canonical and non-canonical Wnt signalings in brain ECs were downregulated after ischemia/reperfusion injury in vitro and in vivo. Upregulating endothelial Wnt/β-catenin signaling in β-cat mice normalized the downregulated non-canonical Wnt signalings, which did not compromise its protective effects on BBB integrity and endothelial tight junction following ischemic stroke.

Conclusions: The BBB protection induced by upregulation of endothelial Wnt/β-catenin signaling may be not interfered by the normalization of non-canonical Wnt signalings in the early stage of ischemic stroke.
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http://dx.doi.org/10.1111/cns.13661DOI Listing
May 2021

Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations.

Cell 2021 Jun 28;184(13):3542-3558.e16. Epub 2021 May 28.

State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu, Sichuan, China. Electronic address:

Structural variations (SVs) and gene copy number variations (gCNVs) have contributed to crop evolution, domestication, and improvement. Here, we assembled 31 high-quality genomes of genetically diverse rice accessions. Coupling with two existing assemblies, we developed pan-genome-scale genomic resources including a graph-based genome, providing access to rice genomic variations. Specifically, we discovered 171,072 SVs and 25,549 gCNVs and used an Oryza glaberrima assembly to infer the derived states of SVs in the Oryza sativa population. Our analyses of SV formation mechanisms, impacts on gene expression, and distributions among subpopulations illustrate the utility of these resources for understanding how SVs and gCNVs shaped rice environmental adaptation and domestication. Our graph-based genome enabled genome-wide association study (GWAS)-based identification of phenotype-associated genetic variations undetectable when using only SNPs and a single reference assembly. Our work provides rich population-scale resources paired with easy-to-access tools to facilitate rice breeding as well as plant functional genomics and evolutionary biology research.
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http://dx.doi.org/10.1016/j.cell.2021.04.046DOI Listing
June 2021

Long-read genome assembly and genetic architecture of fruit shape in the bottle gourd.

Plant J 2021 May 27. Epub 2021 May 27.

Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China.

The bottle gourd (Lagenaria siceraria, Cucurbitaceae) is an important horticultural crop exhibiting tremendous diversity in fruit shape. The genetic architecture of fruit shape variation in this species remains unknown. We assembled a long-read-based, high-quality reference genome (ZAAS_Lsic_2.0) with a contig N50 value over 390-fold greater than the existing reference genomes. We then focused on dissection of fruit shape using a one-step geometric morphometrics-based functional mapping approach. We identified 11 quantitative trait loci (QTLs) responsible for fruit shape (fsQTLs), reconstructed their visible effects and revealed syntenic relationships of bottle gourd fsQTLs with 12 fsQTLs previously reported in cucumber, melon or watermelon. Homologs of several well-known and newly identified fruit shape genes, including SUN, OFP, AP2 and auxin transporters, were comapped with bottle gourd QTLs.
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http://dx.doi.org/10.1111/tpj.15358DOI Listing
May 2021

Build an implanted "arsenal": detachable microneedles for NIR-triggered cancer photothermo-chemotherapy.

Biomater Sci 2021 Jul 25;9(13):4737-4745. Epub 2021 May 25.

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, P. R. China.

The current trend in tumor research is shifting from monotherapy to multimodal therapy. However, how to achieve on-demand drug delivery and minimize the invasiveness of treatment are still big challenges. Herein, we present a detachable microneedles (MNs) system, which consists of polycaprolactone (PCL) needles and polyvinylpyrrolidone/poly (vinyl alcohol) substrate, to build an implanted drug depot for on-demand photothermo-chemotherapy. Owing to the dissolvability of the substrate, detachable MNs can intradermally implant PCL needles loaded with photothermal conversion agent Prussian blue nanocubes (PB NCs) and chemotherapeutics doxorubicin hydrochloride (Dox·HCl). Once near-infrared light irradiates, PB NCs could translate light to local regional hyperthermia, which not only ablates cancer cells but also meltPCL to accelerate the diffusion of Dox·HCl. These MNs displayed a stable and repeatable photothermal effect under NIR irradiation. The ex vivo experiments using isolated swine skin demonstrated the as needed Dox·HCl delivery triggered by NIR light. Moreover, the robust antitumor efficacy of the MN system was proved in KB tumor-bearing nude mice under three timed NIR irradiation. Therefore, the developed detachable MNs which could build implanted "arsenal" for on-demand photothermo-chemotherapy have a bright future in tumor suppression.
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http://dx.doi.org/10.1039/d1bm00520kDOI Listing
July 2021

14-3-3 is a VP3-binding protein involved in Macrobrachium rosenbergii Taihu virus infection in shrimp.

Dev Comp Immunol 2021 Sep 21;122:104139. Epub 2021 May 21.

School of Life Sciences, Shaoxing University, Shaoxing, 312000, China. Electronic address:

Macrobrachium rosenbergii Taihu virus (MrTV) is a fierce pathogen that causes high mortality in M. rosenbergii larvae. Little is known about the pathogenesis of MrTV and host-virus interactions. In this study, a virus overlay protein binding assay (VOPBA), followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, was carried out to search for novel host molecules that bind with VP3, one of the main capsid proteins of MrTV. Macrobrachium rosenbergii 14-3-3 protein (Mr14-3-3) was identified as the binding protein of VP3, which was further confirmed by co-immunoprecipitation (Co-IP) and co-localization assay. A preincubation assay was developed, which indicated that preincubation with recombinant Mr14-3-3 (rMr14-3-3) could significantly decrease the expression level of VP3 in MrTV-infected M. rosenbergii larvae, suggesting that preincubation with rMr14-3-3 could partially block MrTV infection. This study revealed that Mr14-3-3 acts as a binding protein for MrTV-VP3 and plays an important role in MrTV infection, offering a potential target for the development of anti-MrTV therapies.
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http://dx.doi.org/10.1016/j.dci.2021.104139DOI Listing
September 2021

Low-Noise Dual-Band Polarimetric Image Sensor Based on 1D Bi S Nanowire.

Adv Sci (Weinh) 2021 Jul 21;8(14):e2100075. Epub 2021 May 21.

State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, China.

With the increasing demand for detection accuracy and sensitivity, dual-band polarimetric image sensor has attracted considerable attention due to better object recognition by processing signals from diverse wavebands. However, the widespread use of polarimetric sensors is still limited by high noise, narrow photoresponse range, and low linearly dichroic ratio. Recently, the low-dimensional materials with intrinsic in-plane anisotropy structure exhibit the great potential to realize direct polarized photodetection. Here, strong anisotropy of 1D layered bismuth sulfide (Bi S ) is demonstrated experimentally and theoretically. The Bi S photodetector exhibits excellent device performance, which enables high photoresponsivity (32 A W ), I /I ratio (1.08 × 10 ), robust linearly dichroic ratio (1.9), and Hooge parameter (2.0 × 10 at 1 Hz) which refer to lower noise than most reported low-dimensional materials-based devices. Impressively, such Bi S nanowire exhibits a good broadband photoresponse, ranging from ultraviolet (360 nm) to short-wave infrared (1064 nm). Direct polarimetric imaging is implemented at the wavelengths of 532 and 808 nm. With these remarkable features, the 1D Bi S nanowires show great potential for direct dual-band polarimetric image sensors without using any external optical polarizer.
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http://dx.doi.org/10.1002/advs.202100075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292854PMC
July 2021

Molecular mechanisms of mutualistic and antagonistic interactions in a plant-pollinator association.

Nat Ecol Evol 2021 Jul 17;5(7):974-986. Epub 2021 May 17.

Center for Genomics and Biotechnology, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Key Laboratory of Genetics, Breeding and Multiple Utilization of Corps, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.

Many insects metamorphose from antagonistic larvae into mutualistic adult pollinators, with reciprocal adaptation leading to specialized insect-plant associations. It remains unknown how such interactions are established at molecular level. Here we assemble high-quality genomes of a fig species, Ficus pumila var. pumila, and its specific pollinating wasp, Wiebesia pumilae. We combine multi-omics with validation experiments to reveal molecular mechanisms underlying this specialized interaction. In the plant, we identify the specific compound attracting pollinators and validate the function of several key genes regulating its biosynthesis. In the pollinator, we find a highly reduced number of odorant-binding protein genes and an odorant-binding protein mainly binding the attractant. During antagonistic interaction, we find similar chemical profiles and turnovers throughout the development of galled ovules and seeds, and a significant contraction of detoxification-related gene families in the pollinator. Our study identifies some key genes bridging coevolved mutualists, establishing expectations for more diffuse insect-pollinator systems.
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http://dx.doi.org/10.1038/s41559-021-01469-1DOI Listing
July 2021

Spectroscopic evidence of superconductivity pairing at 83 K in single-layer FeSe/SrTiO films.

Nat Commun 2021 May 14;12(1):2840. Epub 2021 May 14.

National Lab for Superconductivity, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.

Single-layer FeSe films grown on the SrTiO substrate (FeSe/STO) have attracted much attention because of their possible record-high superconducting critical temperature (T) and distinct electronic structures. However, it has been under debate on how high its T can really reach due to the inconsistency of the results from different measurements. Here we report spectroscopic evidence of superconductivity pairing at 83 K in single-layer FeSe/STO films. By preparing high-quality single-layer FeSe/STO films, we observe strong superconductivity-induced Bogoliubov back-bending bands that extend to rather high binding energy ~ 100 meV by high-resolution angle-resolved photoemission measurements. They provide a new definitive benchmark of superconductivity pairing that is directly observed up to 83 K. Moreover, we find that the pairing state can be further divided into two temperature regions. These results indicate that either T as high as 83 K is achievable, or there is a pseudogap formation from superconductivity fluctuation in single-layer FeSe/STO films.
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http://dx.doi.org/10.1038/s41467-021-23106-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121788PMC
May 2021

Immune checkpoint inhibitor plus tyrosine kinase inhibitor for unresectable hepatocellular carcinoma in the real world.

Ann Transl Med 2021 Apr;9(8):652

Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.

Background: This study aimed to evaluate safety and efficacy of programmed death-1 (PD-1) inhibitor sintilimab plus tyrosine kinase inhibitors (TKI) in a real-word cohort of patients with unresectable hepatocellular carcinoma (uHCC).

Methods: A total of 60 patients treated with sintilimab plus TKI between February 2019 and December 2019 were enrolled. Radiological response was recorded by computed tomography (CT) or magnetic resonance imaging (MRI) at baseline and every 6-12 weeks after treatment initiation. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and HCC-specific modified RECIST (mRECIST).

Results: As of the data cutoff on September 30st, 2020, the median duration of follow-up was 10.4 (4.3-23.9) months. The objective response rate (ORR) and disease control rate (DCR) were 36.7% (95% CI: 24.9-48.5%), 81.7% (95% CI: 71.9-91.5%) according to the RECIST 1.1, and 52.8% (95% CI: 39.1-66.5%), 83.0% (95% CI: 73.2-93.8%) according to mRECIST criteria. Among 36 HCC patients with multinodular HCC or locally-advanced HCC with portal vein tumor thrombus (PVTT), 14 patients received one session of transarterial chemoembolization (TACE) within 1 month before or after the combinational systemic therapies, and the rest 22 patients did not receive any local regional therapies. After propensity score matching, patients from the TACE group tended to have a longer PFS (median, 10.1 9.1 months, P=0.73) than those from the non-TACE group but without significant differences. A total of 8 patients received surgical resection after the combined systemic therapies and 3 patients achieved pathological CR. No recurrence or metastasis was observed in 6 patients. A total of 46 (76.7%) patients reported adverse event (AE) with any grade and 8 (13.3%) patients discontinued the combination therapy due to grade 3/4 severe adverse events.

Conclusions: PD-1-targeted immunotherapy sintilimab plus TKIs exhibited promising efficacy with tolerable toxicity in unresectable HCC. The addition of TACE to the combined systemic therapies also resulted in a favorable tumor control and safety. For select responders, surgical resection might be a choice for radical treatment.
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http://dx.doi.org/10.21037/atm-20-7037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106062PMC
April 2021

Laparoscopic vs. Open Repeat Hepatectomy for Recurrent Liver Tumors: A Propensity Score-Matched Study and Meta-Analysis.

Front Oncol 2021 22;11:646737. Epub 2021 Apr 22.

Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

It remains unclear whether the short-term benefits of laparoscopic repeat hepatectomy (LRH) accrue to patients with recurrent liver tumors. The present study aimed to report our own center's experience and perform a meta-analysis to evaluate the safety and feasibility of LRH in comparison with open repeat hepatectomy (ORH) for treating recurrent liver tumors. A propensity score-matched study was performed including 426 patients receiving LRH or ORH for recurrent hepatocellular carcinoma between January 2017 and December 2018. Surgical outcomes and perioperative inflammation-based markers, including monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index were collected from medical records and analyzed. Additionally, a systematic literature review was performed to identify relevant studies in PubMed, EMBASE, Web of Science, and Cochrane library databases up to October 1, 2020. Information including patient demographics, pathologic characteristics, and short-term outcomes was extracted and analyzed using random- or fixed-effects models. Of 68 LRHs, 57 were matched with an ORH finally. Our study demonstrated that LRH was significantly associated with less intraoperative blood loss (50 vs. 100 mL; < 0.001), lower rate of hepatic inflow occlusion (10.52 vs. 33.3%; = 0.003), and shorter postoperative hospital stay (5 vs. 6 days; = 0.001) after 1:1 propensity score matching. The operation time, rate of blood transfusion, and postoperative complications were similar between the two groups. Moreover, all four inflammation-based markers were significantly lower in LRH group on postoperative day 1. In the meta-analysis, a total of 12 studies comprising 1,315 patients receiving repeat hepatectomy met the selection criteria. Similar to our own study, the meta-analysis showed shorter hospital stay [standard mean difference (SMD) = -0.51, 95% confidence interval (CI) = -0.79 to -0.22, < 0.001], less intraoperative blood loss (SMD = -0.79, 95% CI = -1.11 to -0.47, < 0.001), and lower rate of major postoperative complications [odds ratio (OR) = 0.35, 95% CI = 0.19-0.66, = 0.001] in the LRH group. There was no difference in the field of overall postoperative complication and operation time between LRH and ORH groups. Compared with ORH, LRH results in relatively better surgical outcomes and faster postoperative recovery. It could be considered a feasible and effective option for the treatment of recurrent liver tumors.
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http://dx.doi.org/10.3389/fonc.2021.646737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100033PMC
April 2021

Feature Selection Methods for Protein Biomarker Discovery from Proteomics or Multiomics Data.

Mol Cell Proteomics 2021 Apr 20;20:100083. Epub 2021 Apr 20.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Untargeted mass spectrometry (MS)-based proteomics provides a powerful platform for protein biomarker discovery, but clinical translation depends on the selection of a small number of proteins for downstream verification and validation. Due to the small sample size of typical discovery studies, protein markers identified from discovery data may not be generalizable to independent datasets. In addition, a good protein marker identified using a discovery platform may be difficult to implement in verification and validation platforms. Moreover, although multiomics characterization is being increasingly used in discovery cohort studies, there is no existing method for multiomics-facilitated protein biomarker selection. Here, we present ProMS, a computational algorithm for protein marker selection. The algorithm is based on the hypothesis that a phenotype is characterized by a few underlying biological functions, each manifested by a group of coexpressed proteins. A weighted k-medoids clustering algorithm is applied to all univariately informative proteins to identify both coexpressed protein clusters and a representative protein for each cluster as markers. In two clinically important classification problems, ProMS shows superior performance compared with existing feature selection methods. ProMS can be extended to the multiomics setting (ProMS_mo) through a constrained weighted k-medoids clustering algorithm, and the protein panels selected by ProMS_mo show improved performance on independent test data compared with ProMS. In addition to superior performance, ProMS and ProMS_mo also have two unique strengths. First, the feature clusters enable functional interpretation of the selected protein markers. Second, the feature clusters provide an opportunity to select replacement protein markers, facilitating a robust transition to the verification and validation platforms. In summary, this study provides a unified and effective computational framework for selecting protein biomarkers using proteomics or multiomics data. The software implementation is publicly available at https://github.com/bzhanglab/proms.
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http://dx.doi.org/10.1016/j.mcpro.2021.100083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165452PMC
April 2021

Intercalated architecture of MAZ family layered van der Waals materials with emerging topological, magnetic and superconducting properties.

Nat Commun 2021 Apr 21;12(1):2361. Epub 2021 Apr 21.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 110016, Shenyang, People's Republic of China.

The search for new two-dimensional monolayers with diverse electronic properties has attracted growing interest in recent years. Here, we present an approach to construct MAZ monolayers with a septuple-atomic-layer structure, that is, intercalating a MoS-type monolayer MZ into an InSe-type monolayer AZ. We illustrate this unique strategy by means of first-principles calculations, which not only reproduce the structures of MoSiN and MnBiTe that were already experimentally synthesized, but also predict 72 compounds that are thermodynamically and dynamically stable. Such an intercalated architecture significantly reconstructs the band structures of the constituents MZ and AZ, leading to diverse electronic properties for MAZ, which can be classified according to the total number of valence electrons. The systems with 32 and 34 valence electrons are mostly semiconductors. Whereas, those with 33 valence electrons can be nonmagnetic metals or ferromagnetic semiconductors. In particular, we find that, among the predicted compounds, (Ca,Sr)GaTe are topologically nontrivial by both the standard density functional theory and hybrid functional calculations. While VSiP is a ferromagnetic semiconductor and TaSiN is a type-I Ising superconductor. Moreover, WSiP is a direct gap semiconductor with peculiar spin-valley properties, which are robust against interlayer interactions. Our study thus provides an effective way of designing septuple-atomic-layer MAZ with unusual electronic properties to draw immediate experimental interest.
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http://dx.doi.org/10.1038/s41467-021-22324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060390PMC
April 2021

Molecular Disorder Induces an Unusual Phase Transition in a Potential 2D Chiral Ferroelectric Perovskite.

Chemistry 2021 Jun 19;27(35):9054-9059. Epub 2021 May 19.

Hubei Key Laboratory of Optical Information and Pattern Recognition, Wuhan Institute of Technology, Wuhan, 430205, P. R. China.

Two-dimensional hybrid halide perovskites with single chiral and ferroelectricity together with various structural phase transitions provide the possibility for more diverse functional properties. Here, we present a 2D chiral hybrid halide perovskite ferroelectric, [C H (CH ) NH ] CdCl (4PBA-CdCl , 4PBA=4-phenylbutylamine) that experiences two continuous phase transitions from centrosymmetric triclinic P to polar chiral monoclinic P2 and then to another centrosymmetric tetragonal P4/mmm with increasing temperature, accompanied by symmetry breaking, due to the prominent octahedral distortion and disorder transformation of organic 4PBA cations. In the polar chiral phase, 4PBA-CdCl gives a significant CD signal and has a moderate ferroelectric polarization of 0.35 μC/cm . In addition, 4PBA-CdCl occupies a wide band gap of 4.376 eV that is chiefly contributed by the inorganic CdCl octahedron. This finding offers an alternative pathway for designing new phase transitions and related physical properties in hybrid halide perovskites and other hybrid crystals.
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http://dx.doi.org/10.1002/chem.202100334DOI Listing
June 2021

Proteomic analysis of individual giant freshwater prawn, Macrobrachium rosenbergii, growth retardants.

J Proteomics 2021 06 9;241:104224. Epub 2021 Apr 9.

Agriculture Ministry Key Laboratory of Healthy Freshwater Aquaculture, Key Laboratory of Freshwater Aquatic Animal Genetic and Breeding of Zhejiang province, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China. Electronic address:

"Iron prawn" is a condition of severe growth retardation that fishers call. The giant river prawn (Macrobrachium rosenbergii) is a commercially important species contains high protein content and functional nutrients. However, no proteomic information is available for this species. We performed the shotgun 2DLC-MS/MS proteomic analysis of the total protein from "iron prawn". Total 19,758 peptides corresponding to 2613 high-confidence proteins were identified. These proteins range in size from 40 to 70 kDa. KEGG analysis revealed that the largest group consisting total 102 KEGG pathway proteins comparing the "iron prawn" with the normal prawn. Additionally, 7, 11, 1, 6, and 5 commercially important enzymes were found in the eyestalk, liver, muscle, ovary, and testis, respectively. The functions of these differently expressed enzymes include immune system action against pathogens, muscle contraction, digestive system metabolism, cell differentiation, migration, and apoptosis in the severe growth retardation of "iron prawn". Our work provides insight into the understanding of the formation mechanism of "iron prawn".
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http://dx.doi.org/10.1016/j.jprot.2021.104224DOI Listing
June 2021

Using deep learning to predict microvascular invasion in hepatocellular carcinoma based on dynamic contrast-enhanced MRI combined with clinical parameters.

J Cancer Res Clin Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Liver Surgery, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

Purpose: Microvascular invasion (MVI) is a critical determinant of the early recurrence and poor prognosis of patients with hepatocellular carcinoma (HCC). Prediction of MVI status is clinically significant for the decision of treatment strategies and the assessment of patient's prognosis. A deep learning (DL) model was developed to predict the MVI status and grade in HCC patients based on preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical parameters.

Methods: HCC patients with pathologically confirmed MVI status from January to December 2016 were enrolled and preoperative DCE-MRI of these patients were collected in this study. Then they were randomly divided into the training and testing cohorts. A DL model with eight conventional neural network (CNN) branches for eight MRI sequences was built to predict the presence of MVI, and further combined with clinical parameters for better prediction.

Results: Among 601 HCC patients, 376 patients were pathologically MVI absent, and 225 patients were MVI present. To predict the presence of MVI, the DL model based only on images achieved an area under curve (AUC) of 0.915 in the testing cohort as compared to the radiomics model with an AUC of 0.731. The DL combined with clinical parameters (DLC) model yielded the best predictive performance with an AUC of 0.931. For the MVI-grade stratification, the DLC models achieved an overall accuracy of 0.793. Survival analysis demonstrated that the patients with DLC-predicted MVI status were associated with the poor overall survival (OS) and recurrence-free survival (RFS). Further investigation showed that hepatectomy with the wide resection margin contributes to better OS and RFS in the DLC-predicted MVI present patients.

Conclusion: The proposed DLC model can provide a non-invasive approach to evaluate MVI before surgery, which can help surgeons make decisions of surgical strategies and assess patient's prognosis.
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http://dx.doi.org/10.1007/s00432-021-03617-3DOI Listing
April 2021

[Interpolation Algorithm for Motion Vector Field of CTA Image and Accelerated Implementation Based on Uniform Grid and Multi-level B-spline].

Zhongguo Yi Liao Qi Xie Za Zhi 2021 Apr;45(2):131-135

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240.

In order to solve the problems of slow operation speed and low registration accuracy of thin plate spline (TPS) interpolation method for motion vector field in coronary computed tomography angiography (CTA), a multi-level B-spline interpolation method (MBS) with uniform grid is proposed. On the one hand, the interpolation method used local B-spline to refine the sparse mesh layer by layer in a multiscale way to improve the accuracy of registration. On the other hand, it used the splitting matrix method to interpolate the motion vector field, greatly reducing the operation time of interpolation. The experimental results show that the proposed method can be used for CTA image registration efficiently.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2021.02.003DOI Listing
April 2021

Analysis of Approaches in the Microsurgical Treatment of 102 Cases of Petroclival Meningioma in a Single Center.

Front Neurol 2021 19;12:627736. Epub 2021 Mar 19.

Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

We identified the optimal approaches for treating the diverse tumor subtypes of petroclival meningioma (PM) by analyzing the clinical benefits of various surgical approaches adopted for each subtype. Tumors in 102 PM patients from a single center who underwent surgical treatment were classified as upper clivus (UC), cavernous sinus (CS), tentorium (TE), or petrous apex (PA) types based on the attachment site of the tumor base and the displacement of the trigeminal nerve. The therapeutic effects of different surgical approaches among the subtypes were evaluated according to the patient outcomes. The subtemporal (33.33%), retrosigmoid (16.67%), and Kawase approaches (50%) were used for the UC type. Simpson I/II resection was achieved in 46.66% of patients with the Kawase approach. Significant differences were found between the other two approaches ( = 0.044) and in the follow-up Karnofsky performance scale (KPS) scores ( = 0.008). The subtemporal (60%) and Kawase approaches (40%) were used for the CS type; neither approach achieved Simpson I/II resection. The retrosigmoid (25.81%) and Kawase approaches (74.19%) were used for the TE type. The Simpson I/II resection rates of the two approaches were 55.55 and 86.95%, respectively, and a significant difference was observed between them ( = 0.039). The retrosigmoid (43.75%) and Kawase approaches (56.25%) were used for the PA type. The Simpson I/II resection rates of the two approaches were 31.25 and 50%, respectively. The resection degrees of the two approaches and the KPS scores at follow-up were significantly different ( = 0.034). The individual microsurgical approaches adopted for the various PM tumor subtypes can provide maximal safe resection and good KPS scores. The Kawase approach is more suitable for PM, especially for UC- and PA-type PM tumors.
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http://dx.doi.org/10.3389/fneur.2021.627736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018277PMC
March 2021

Triboelectric Rotary Motion Sensor for Industrial-Grade Speed and Angle Monitoring.

Sensors (Basel) 2021 Mar 2;21(5). Epub 2021 Mar 2.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Mechanical motion sensing and monitoring is an important component in the field of industrial automation. Rotary motion is one of the most basic forms of mechanical motion, so it is of great significance for the development of the entire industry to realize rotary motion state monitoring. In this paper, a triboelectric rotary motion sensor (TRMS) with variable amplitude differential hybrid electrodes is proposed, and an integrated monitoring system (IMS) is designed to realize real-time monitoring of industrial-grade rotary motion state. First, the operating principle and monitoring characteristics are studied. The experiment results indicate that the TRMS can achieve rotation speed measurement in the range of 10-1000 rpm with good linearity, and the error rate of rotation speed is less than 0.8%. Besides, the TRMS has an angle monitoring range of 360° and its resolution is 1.5° in bidirectional rotation. Finally, the applications of the designed TRMS and IMS prove the feasibility of self-powered rotary motion monitoring. This work further promotes the development of triboelectric sensors (TESs) in industrial application.
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http://dx.doi.org/10.3390/s21051713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958622PMC
March 2021