Publications by authors named "Qian Ma"

376 Publications

Stable flexible photodetector based on FePS/reduced graphene oxide heterostructure with significant enhancement in photoelectrochemical performance.

Nanotechnology 2021 Jul 22. Epub 2021 Jul 22.

School of Physics and Optoelectronics, Xiangtan University, School of Physics and Optoelectronics, Xiangtan University, Hunan 411105, PR China, Xiangtan, Hunan, 411105, CHINA.

Herein, FePS3/reduced graphene oxide (rGO) heterostructure has been prepared via a typical hydrothermal process, and flexible photodetectors based on hybrids have been subsequently fabricated. The photoresponse measurement results demonstrate that the photodetector exhibits obvious photoelectric conversion behavior without applied potential, indicating the device possesses capability of self-powered. In addition, the photocurrent density of as-fabricated photodetectors reaches up to 125 nA/cm2 under 90 mW/cm2 of illumination intensity without external power source, which is 5.86 times higher than sole FePS3-based devices. Furthermore, the maximum attenuation in photocurrent density of as-fabricated flexible photodetectors measured at -0.3 V after different bending cycles and bending angles are 29.8 % and 17.7 %, respectively. These results demonstrate that as-fabricated photodetectors have excellent flexibility and provide a simple and effective strategy for the construction of flexible photodetector.
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http://dx.doi.org/10.1088/1361-6528/ac1719DOI Listing
July 2021

Quantification of early learning and movement sub-structure predictive of motor performance.

Sci Rep 2021 Jul 13;11(1):14405. Epub 2021 Jul 13.

Rare Brain Disorders Program, Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Mail Code 8813, Dallas, TX, 75390-8813, USA.

Time-to-fall off an accelerating rotating rod (rotarod) is widely utilized to evaluate rodent motor performance. We reasoned that this simple outcome could be refined with additional measures explicit in the task (however inconspicuously) to examine what we call movement sub-structure. Our goal was to characterize normal variation or motor impairment more robustly than by using time-to-fall. We also hypothesized that measures (or features) early in the sub-structure could anticipate the learning expected of a mouse undergoing serial trials. Using normal untreated and baclofen-treated movement-impaired mice, we defined these features and automated their analysis using paw video-tracking in three consecutive trials, including paw location, speed, acceleration, variance and approximate entropy. Spectral arc length yielded speed and acceleration uniformity. We found that, in normal mice, paw movement smoothness inversely correlated with rotarod time-to-fall for the three trials. Greater approximate entropy in vertical movements, and opposite changes in horizontal movements, correlated with greater first-trial time-to-fall. First-trial horizontal approximate entropy in the first few seconds predicted subsequent time-to-fall. This allowed for the separation, after only one rotarod trial, of different-weight, untreated mouse groups, and for the detection of mice otherwise unimpaired after baclofen, which displayed a time-to-fall similar to control. A machine-learning support vector machine classifier corroborated these findings. In conclusion, time-to-fall off a rotarod correlated well with several measures, including some obtained during the first few seconds of a trial, and some responsive to learning over the first two trials, allowing for predictions or preemptive experimental manipulations before learning completion.
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http://dx.doi.org/10.1038/s41598-021-93944-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277799PMC
July 2021

Proso millet (Panicum miliaceum L.): A potential crop to meet demand scenario for sustainable saline agriculture.

J Environ Manage 2021 Jul 5;296:113216. Epub 2021 Jul 5.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A & F University, Yangling, Shaanxi, China. Electronic address:

Proso millet (Panicum miliaceum L.) is resilient to abiotic stress, especially to land degradation caused by soil salinization. However, the mechanisms by which its roots adapt and tolerate salt stress are obscure. In this study, plants of a salt-sensitive cultivar (SS 212) and a salt-tolerant cultivar (ST 47) of proso millet were exposed to severe salt stress and subsequent re-watering. ST 47 exhibited greater salt tolerance than SS 212, as evidenced by higher increases in total root length (TRL), root surface area (RSA), root tip number (RTN). Moreover, microstructural analysis showed that relative to SS 212, the roots of ST 47 could maintain more intact internal structures and thicker cell walls under salt stress. Digital RNA sequence analysis revealed that ST 47 maintained better Na/K balance to resist Na toxicity via a higher capability to restrict Na uptake, vacuolar Na sequestration, and Na exclusion. The mechanism for Na toxicity resistance in ST 47 involved promoting cell wall composition changes via efficient regulation of galactose metabolism and biosynthesis of cellulose and phenylpropanoids. Overall, this study provides valuable salt-tolerant cultivar resources and mechanisms for regulating salt tolerance, which could be applied for the rehabilitation of saline lands.
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http://dx.doi.org/10.1016/j.jenvman.2021.113216DOI Listing
July 2021

Reconfigurable Parametric Amplifications of Spoof Surface Plasmons.

Adv Sci (Weinh) 2021 Jul 4:e2100795. Epub 2021 Jul 4.

Institute of Electromagnetic Space, Southeast University, Nanjing, 210096, China.

Next-generation inter-chip communication requires ultrafast ultra-compact interconnects. Designer plasmonics offers a possible route towards this goal. Further development of the plasmonic technique to circuit applications requires the direct amplification of plasmonic signals on a compact platform. However, significant signal distortions and limited operational speeds prevent the application of traditional MOS-based amplifiers to plasmonics. Up to day, the amplification of surface plasmons without phase distortion has remained a scientific challenge. In this work, the concept of parametric amplification (PA) is transplanted to the plasmonics and is realized experimentally an ultrathin reconfigurable PA using a spoof surface plasmon polariton (SSPP) waveguide integrated with tunable and nonlinear varactors. The measured parametric gain in the experiment can reach up to 9.14 dB within a short nonlinear propagation length, for example, six SSPP wavelengths, in excellent agreement with the theoretical prediction. By tuning the bias voltage of varactors, the phase-matching condition can be precisely controlled over a broad frequency band, enabling the authors to realize the multi-frequency PA of plasmonic signals. Measured phase responses confirm that the plasmonic parametric amplifier can significantly suppress the signal distortions as compared with the traditional MOS-based amplifier, which is a property highly desired for ultrafast wireless communication systems and integrated circuits.
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http://dx.doi.org/10.1002/advs.202100795DOI Listing
July 2021

An ultrasound-guided posterior approach when performing the quadratus lumborum block provides pain relief after mastectomy: A case series.

J Clin Anesth 2021 Jul 1;74:110417. Epub 2021 Jul 1.

Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2021.110417DOI Listing
July 2021

Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.

Front Mol Biosci 2021 9;8:675683. Epub 2021 Jun 9.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen-Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.

N6-methyladenosine (mA) RNA modification is the most common internal mRNA modification in mammals and has been reported to play a key role in gene expression regulation. In this study, we detected a high level of mA methylation of the PLOD2 3'-untranslated regions (3'UTR) in renal cell carcinoma (RCC). Furthermore, we found that the high expression level of PLOD2 was a prognostic indicator for patients with RCC. A dmACRISPR demethylation system was performed to accurately and specifically demethylate 3'UTR of PLOD2 and caused an inactivation of PLOD2 expression. Furthermore, we also performed many experiments to confirm that PLOD2 exerted tumor promoter effects by promoting tumor proliferation and migration. In conclusion, PLOD2 mRNA demethylated by dCas13b-ALKBH5 might provide a new light on the treatment for RCC.
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http://dx.doi.org/10.3389/fmolb.2021.675683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220145PMC
June 2021

Identification of hub genes, pathways, and related transcription factors in systemic lupus erythematosus: A preliminary bioinformatics analysis.

Medicine (Baltimore) 2021 Jun;100(25):e26499

Department of Medical Genetics and Cell Biology, Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Heredity of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, PR China.

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ damage and the production of a variety of autoantibodies. The pathogenesis of SLE has not been fully defined, and it is difficult to treat. Our study aimed to identify candidate genes that may be used as biomarkers for the screening, diagnosis, and treatment of SLE.

Methods: We used the GEO2R tool to identify the differentially expressed genes (DEGs) in SLE-related datasets retrieved from the Gene Expression Omnibus (GEO). In addition, we also identified the biological functions of the DEGs by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Additionally, we constructed protein-protein interaction (PPI) networks to identify hub genes, as well as the regulatory network of transcription factors related to DEGs.

Results: Two datasets were identified for use from the GEO (GSE50772, GSE4588), and 34 up-regulated genes and 4 down-regulated genes were identified by GEO2R. Pathway analysis of the DEGs revealed enrichment of the interferon alpha/beta signaling pathway; GO analysis was mainly enriched in response to interferon alpha, regulation of ribonuclease activity. PPIs were constructed through the STRING database and 14 hub genes were selected and 1 significant module (score = 12.923) was obtained from the PPI network. Additionally, 11 key transcription factors that interacted closely with the 14 hub DEGs were identified from the gene transcription factor network.

Conclusions: Bioinformatic analysis is an effective tool for screening the original genomic data in the GEO database, and a large number of SLE-related DEGs were identified. The identified hub DEGs may be potential biomarkers of SLE.
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http://dx.doi.org/10.1097/MD.0000000000026499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238284PMC
June 2021

Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues.

Bioact Mater 2021 Dec 23;6(12):4717-4728. Epub 2021 May 23.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200438, China.

It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues. Herein, we designed a novel macromolecular contrast agent with ultrahigh radiopacity (iodinate content > 50%) via polymerizing an iodinated trimethylene carbonate monomer into the two ends of poly(ethylene glycol) (PEG). A set of thermosensitive and biodegradable polyester-PEG-polyester triblock copolymers with varied polyester compositions synthesized by us, which were soluble in water at room temperature and could spontaneously form hydrogels at body temperature, were selected as the demonstration materials. The addition of macromolecular contrast agent did not obviously compromise the injectability and thermogelation properties of polymeric hydrogels, but conferred them with excellent X-ray opacity, enabling visualization of the hydrogels at clinically relevant depths through X-ray fluoroscopy or Micro-CT. In a mouse model, the 3D morphology of the radiopaque hydrogels after injection into different target sites was visible using Micro-CT imaging, and their injection volume could be accurately obtained. Furthermore, the subcutaneous degradation process of a radiopaque hydrogel could be non-invasively monitored in a real-time and quantitative manner. In particular, the corrected degradation curve based on Micro-CT imaging well matched with the degradation profile of virgin polymer hydrogel determined by the gravimetric method. These findings indicate that the macromolecular contrast agent has good universality for the construction of various radiopaque polymer hydrogels, and can nondestructively trace and quantify their degradation . Meanwhile, the present methodology developed by us affords a platform technology for deep tissue imaging of polymeric materials.
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http://dx.doi.org/10.1016/j.bioactmat.2021.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165329PMC
December 2021

Neutrophil-lymphocyte ratio as a prognostic factor for minute clear cell renal cell carcinoma diagnosed using multi-slice spiral CT.

Medicine (Baltimore) 2021 Jun;100(23):e26292

Department of Radiology, Urumqi Friendship Hospital, No. 558 Shengli Road, Tianshan District, 830049 Urumqi, P.R. China.

Abstract: Minute clear cell renal cell carcinoma (MccRCC) has a diameter of <1.5 cm and can be diagnosed using multi-slice spiral CT (MSCT). Recently, the role of the neutrophil-lymphocyte ratio (NLR) in the development of MccRCC has attracted attention. This study aimed to further explore the relationship between the NLR and MccRCC.This was a prospective study of 100 patients who were diagnosed with MccRCC using MSCT at Urumqi Friendship Hospital, China. The study investigated a series of pretreatment factors, including NLR and patients' general clinical data. Statistical methods employed included Pearson's chi-square test, Spearman-rho correlation test, Cox regression analysis, and receiver operator characteristic curve analysis.Based on Pearson's χ2, Spearman-rho test, and univariate/multivariate Cox regression analysis, the overall survival of patients with MccRCC was shown to be significantly related to NLR (P < .001). NLR (hazard ratio = 50.676, 95%CI, 17.543-146.390, P < .001) is a significant independent risk-factor for MccRCC. A receiver operator characteristic curve was plotted to examine specificity and sensitivity between NLR and MccRCC (area under curve = 0.958, P < .001).The level of the NLR plays a crucial role in the survival of patients with MccRCC, as diagnosed with MSCT. The higher the NLR, the worse the prognosis for patients with MccRCC.
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http://dx.doi.org/10.1097/MD.0000000000026292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202639PMC
June 2021

Disruption of endothelial Pfkfb3 ameliorates diet-induced murine insulin resistance.

J Endocrinol 2021 Jul 14;250(3):93-104. Epub 2021 Jul 14.

Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Overnutrition-induced endothelial inflammation plays a crucial role in high-fat diet (HFD)-induced insulin resistance in animals. Endothelial glycolysis plays a critical role in endothelial inflammation and proliferation, but its role in diet-induced endothelial inflammation and subsequent insulin resistance has not been elucidated. PFKFB3 is a critical glycolytic regulator, and its increased expression has been observed in adipose vascular endothelium of C57BL/6J mice fed with HFD in vivo, and in palmitate (PA)-treated primary human adipose microvascular endothelial cells (HAMECs) in vitro. We generated mice with Pfkfb3 deficiency selective for endothelial cells to examine the effect of endothelial Pfkfb3 in endothelial inflammation in metabolic organs and in the development of HFD-induced insulin resistance. EC Pfkfb3-deficientmice exhibited mitigated HFD-induced insulin resistance, including decreased body weight and fat mass, improved glucose clearance and insulin sensitivity, and alleviated adiposity and hepatic steatosis. Mechanistically, cultured PFKFB3 knockdown HAMECs showed decreased NF-κB activation induced by PA, and consequent suppressed adhesion molecule expression and monocyte adhesion. Taken together, these results demonstrate that increased endothelial PFKFB3 expression promotes diet-induced inflammatory responses and subsequent insulin resistance, suggesting that endothelial metabolic alteration plays an important role in the development of insulin resistance.
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http://dx.doi.org/10.1530/JOE-20-0524DOI Listing
July 2021

Glucose-oxidase like catalytic mechanism of noble metal nanozymes.

Nat Commun 2021 06 7;12(1):3375. Epub 2021 Jun 7.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin, PR China.

Au nanoparticles (NPs) have been found to be excellent glucose oxidase mimics, while the catalytic processes have rarely been studied. Here, we reveal that the process of glucose oxidation catalyzed by Au NPs is as the same as that of natural glucose oxidase, namely, a two-step reaction including the dehydrogenation of glucose and the subsequent reduction of O to HO by two electrons. Pt, Pd, Ru, Rh, and Ir NPs can also catalyze the dehydrogenation of glucose, except that O is preferably reduced to HO. By the electron transfer feature of noble metal NPs, we overcame the limitation that HO must be produced in the traditional two-step glucose assay and realize the rapid colorimetric detections of glucose. Inspired by the electron transport pathway in the catalytic process of natural enzymes, noble metal NPs have also been found to mimic various enzymatic electron transfer reactions including cytochrome c, coenzymes as well as nitrobenzene reductions.
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http://dx.doi.org/10.1038/s41467-021-23737-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184917PMC
June 2021

Global Stabilization for a Class of Stochastic Nonlinear Time-Delay Systems With Unknown Measurement Drifts and Its Application.

IEEE Trans Neural Netw Learn Syst 2021 Jun 7;PP. Epub 2021 Jun 7.

This article studies the control problem for a class of stochastic nonlinear time-delay systems with uncertain output functions. Under the appropriate assumptions, a stabilization controller is explicitly constructed by applying the adding a power integrator method. Then, using the Lyapunov-Krasovskii functionals to address time-delay, it is proven that the designed controller can guarantee the closed-loop system to be globally asymptotically stable (GAS) in probability. Finally, two simulations show that the control strategy is effective and can be applied to the actual system.
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http://dx.doi.org/10.1109/TNNLS.2021.3084295DOI Listing
June 2021

Consensusability of First-Order Multiagent Systems Under Distributed PID Controller With Time Delay.

IEEE Trans Neural Netw Learn Syst 2021 Jun 4;PP. Epub 2021 Jun 4.

This article analyzes the consensus of first-order multiagent systems under the network topology with a directed spanning tree. A distributed PID controller with time delay is designed. D-parameterization approach is used and the crossing set consisting of frequencies such that at least one characteristic root is on the imaginary axis is identified. It is proven that the rightward crossings of the characteristic roots are always guaranteed. The exact delay margin is then determined. Numerical simulation is proposed to demonstrate the theoretical analysis.
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http://dx.doi.org/10.1109/TNNLS.2021.3084366DOI Listing
June 2021

[Advances and prospects in metabolic engineering for the production of amino acids].

Sheng Wu Gong Cheng Xue Bao 2021 May;37(5):1677-1696

College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

Fermentative production of amino acids is one of the pillars of the fermentation industry in China. Recently, with the fast development of metabolic engineering and synthetic biology technologies, the metabolic engineering for production of amino acids has been flourishing. Conventional forward metabolic engineering, reversed metabolic engineering based on omics data and in silico simulation, and evolutionary metabolic engineering mimicking the natural evolution, have shown increasingly promising applications. A series of highly efficient and robust amino acids-producing strains have been developed and applied in the industrial production of amino acids. The increasingly fierce market competition has put forward new requirements for strain breeding and selection, such as developing high value-added amino acids, dynamic regulation of cellular metabolism, and adapting to the requirements of new process. This review summarizes the advances and prospects in metabolic engineering for the production of amino acids.
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http://dx.doi.org/10.13345/j.cjb.200588DOI Listing
May 2021

Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions.

Cell Stem Cell 2021 May 20. Epub 2021 May 20.

RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China; Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address:

Topological-associated domains (TADs) are thought to be relatively stable across cell types, although some TAD reorganization has been observed during cellular differentiation. However, little is known about the mechanisms through which TAD reorganization affects cell fate or how master transcription factors affect TAD structures during cell fate transitions. Here, we show extensive TAD reorganization during somatic cell reprogramming, which is correlated with gene transcription and changes in cellular identity. Manipulating TAD reorganization promotes reprogramming, and the dynamics of concentrated chromatin loops in OCT4 phase separated condensates contribute to TAD reorganization. Disrupting OCT4 phase separation attenuates TAD reorganization and reprogramming, which can be rescued by fusing an intrinsically disordered region (IDR) to OCT4. We developed an approach termed TAD reorganization-based multiomics analysis (TADMAN), which identified reprogramming regulators. Together, these findings elucidate a role and mechanism of TAD reorganization, regulated by OCT4 phase separation, in cellular reprogramming.
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http://dx.doi.org/10.1016/j.stem.2021.04.023DOI Listing
May 2021

Programmable Reflection-Transmission Shared-Aperture Metasurface for Real-Time Control of Electromagnetic Waves in Full Space.

Adv Sci (Weinh) 2021 May 26:e2100149. Epub 2021 May 26.

Institute of Electromagnetic Space, Southeast University, Nanjing, 210096, China.

Recently, programmable metamaterials or metasurfaces have been developed to dynamically edit electromagnetic waves for realizing different functions in the same platform. However, the proposed programmable metasurfaces can only control reflected or transmitted wavefronts in half-space. Here, a "Janus" digital coding metasurface with the capabilities to program various electromagnetic functions in the reflected (with R-codes) and transmitted (with T-codes) waves simultaneously is presented. Three PIN diodes are employed to design the metaparticle, and the state of the PIN diodes can be switched to change the reflected and transmitted phases independently. Three schemes achieved by the proposed programmable metasurface are provided as illustrative examples, including anomalous deflections, beam focusing, and scattering reduction in the full space. As a proof-of-concept, a prototype composed of 10 × 20 metaparticles is fabricated and the measured results are in good agreement with the designs and numerical results, validating the full-space modulations enabled by the programmable metasurface. It is expected that the new programmable metasurface can broaden the applications in stealth technologies, imaging systems, and the next generation of wireless communications.
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http://dx.doi.org/10.1002/advs.202100149DOI Listing
May 2021

miR-183-5p Is a Potential Molecular Marker of Systemic Lupus Erythematosus.

J Immunol Res 2021 6;2021:5547635. Epub 2021 May 6.

Department of Medical Genetics and Cell Biology, College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.

Objective: To investigate microRNA (miRNA) expression profiles in individuals with systemic lupus erythematosus (SLE) and identify the valuable miRNA biomarkers in diagnosing and monitoring SLE.

Methods: Next-generation sequencing (NGS) was performed to assess miRNA amounts in peripheral blood mononuclear cells (PBMCs) from four SLE cases and four healthy controls. Quantitative polymerase chain reaction (qPCR) was carried out for validating candidate miRNAs in 32 SLE cases and 32 healthy controls. In addition, receiver operating characteristic (ROC) curve analysis was completed to evaluate diagnostic performance. Finally, the associations of candidate miRNAs with various characteristics of SLE were analyzed.

Results: A total of 157 miRNAs were upregulated, and 110 miRNAs were downregulated in PBMCs from SLE cases in comparison to healthy controls, of which the increase of miR-183-5p and decrease of miR-374b-3p were validated by qPCR and both showed good diagnostic performance for SLE diagnosis. Besides, miR-183-5p expression levels displayed a positive association with SLE disease activity index (SLEDAI) and anti-dsDNA antibody amounts.

Conclusion: Our data indicated that miR-183-5p is a promising biomarker of SLE.
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http://dx.doi.org/10.1155/2021/5547635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124875PMC
May 2021

Fatal unexpected death due to X-linked lymphoproliferative disease.

Leg Med (Tokyo) 2021 Sep 1;52:101900. Epub 2021 May 1.

Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, Hubei 430030, PR China. Electronic address:

X-linked lymphoproliferative disease (XLP) is a rare immunodeficiency disease characterized by severe immune disorder and extreme vulnerability to Epstein-Barr virus (EBV) infections. Here we report a 14-month-old Chinese boy presenting with fulminant infectious mononucleosis (FIM) following EBV infection, and died of hepatic failure within one week of disease progression. Postmortem examination revealed icterus, ascites, extensive enlarged mesenteric lymphnodes and hepatosplenomegaly. Histopathological examination showed diffuse proliferation of cytotoxic T lymphoid cells and hemophagocytosis in multiple organs. The family history revealed his brother had died under similar circumstances at 5 five years of age. The cause of death of the boy was ascribed to XLP. To the best of our knowledge, there is few autopsy-confirmed XLP case in the forensic practice. The complicatedmanifestations and systemic pathological changes should be well recognized by clinicians and forensic pathologists.
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http://dx.doi.org/10.1016/j.legalmed.2021.101900DOI Listing
September 2021

Highly Efficient Production of -Acetyl-glucosamine in by Appropriate Catabolic Division of Labor in the Utilization of Mixed Glycerol/Glucose Carbon Sources.

J Agric Food Chem 2021 Jun 18;69(21):5966-5975. Epub 2021 May 18.

Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China.

Currently, microbial production is becoming a competitive method for -acetyl-glucosamine production. As the biosynthesis of -acetyl-glucosamine originating from fructose-6-P directly competes with central carbon metabolism for precursor supply, the consumption of glucose for cell growth and cellular metabolism severely limits the yield of -acetyl-glucosamine. In this study, appropriate catabolic division of labor in the utilization of mixed carbon sources was achieved by deleting the gene and enhancing the utilization of glycerol by introducing the mutant. Glycerol thus mainly contributed to cell growth and cellular metabolism, and more glucose was saved for efficient -acetyl-glucosamine synthesis. By optimizing the ratio of glycerol to glucose, the balancing of cell growth/cellular metabolism and -acetyl-glucosamine synthesis was achieved. The resulting strain GLALD-7 produced 179.7 g/L -acetyl-glucosamine using mixed glycerol/glucose (1:8, m/m) carbon sources in a 5 L bioreactor, with a yield of 0.458 g/g total carbon sources (0.529 g/g glucose) and a productivity of 2.57 g/L/h. Coherent high titer/yield/productivity was obtained, with the highest values ever reported, suggesting that an appropriate catabolic division of labor using mixed glycerol/glucose carbon sources is a useful strategy for facilitating the microbial production of chemicals originating from glucose or metabolites upstream of glycolysis.
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http://dx.doi.org/10.1021/acs.jafc.1c01513DOI Listing
June 2021

Characterization of phytochemical components and identification of main antioxidants in Crateva unilocalaris Buch. shoots by UHPLC-Q-Orbitrap-MS analysis.

Food Res Int 2021 05 7;143:110264. Epub 2021 Mar 7.

Faculty of Agriculture and Food, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, Yunnan Province 650500, People's Republic of China. Electronic address:

The chemical constituents and antioxidant activity of the three different extracts (80% methanol, 80% ethanol, and 80% acetone) of Crateva unilocalaris Buch. shoots were investigated. Six phenolic compounds and seven saponins were characterized in all extracts. Chikusetsusaponin IVa had the highest content (17.92 to 29.16 mg/g), and chlorogenic acid was the most abundant phenolic compound (10.48 to 13.99 mg/g). The acetone extract had the highest total phenolic, flavonoid, and saponin contents and the strongest antioxidant activity. Moreover, all extracts exhibited good effects on the inhibition of intracellular ROS generation in HepG2 cells. Phenolic compounds but not saponins contributed significantly to the DPPH or ABTS radical scavenging activity of C. unilocalaris shoots according to the results of DPPH•-UHPLC-HRMS and ABTS•+-UHPLC-HRMS analyses. These results may be helpful for further understandings and utilization of C. unilocalaris shoots as a potential natural source in the food or nutraceuticals industry.
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http://dx.doi.org/10.1016/j.foodres.2021.110264DOI Listing
May 2021

Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.

J Cancer 2021 12;12(11):3367-3377. Epub 2021 Apr 12.

Department of Pathology, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.

The peritoneal implant metastasis is one of the main pathway and main cause for high mortality for gastric cancer metastasis. Researchs show that epithelial-mesenchymal transition (EMT) playing essential role in modulating gastric cancer metastasis, and the expression of hypoxia inducible factor-1α (HIF-1α) can promote EMT in tumor cells. This research aims to explore the influence and mechanism of Dextran Sulfate (DS) affecting EMT of human gastric cancer. In the present study, we found that DS can enter into the cytoplasm and function in it. Inhibition of HIF-1α or DS significantly inhibit the migration and invasion of human gastric cancer cells, and decrease the mRNA and protein expressions of HIF-1α, matrix metalloproteinase-2 (MMP-2), transforming growth factor-β (TGF-β), Twist and N-cadherin (N-cad), rise E-cadherin (E-cad) expression, DS with HIF-1α knockdown has a stronger effect. studies indicated that compared with using DS or HIF-1α knockdown alone, DS with HIF-1α knockdown can better suppress the volume and number of metastatic tumors, and reduce the mRNA and protein expressions of HIF-1α, MMP-2, TGF-β, Twist and N-cad in metastatic tumor tissues of nude mice. We further demonstrated that the expression of HIF-1α, MMP-2, TGF-β , Twist and N-cad were higher in well and poorly differentiated gastric cancer than paracancerous tissue, and poorly differentiated gastric cancer were even higher, while E-cad expression was opposite. Taken together, this study shows that DS can interfere the expression of HIF-1α, thereby inhibiting TGF-β-mediated EMT of gastric cancer cells, and demonstrated a promising application of DS in gastric cancer therapy.
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http://dx.doi.org/10.7150/jca.55550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100798PMC
April 2021

[Genetic and clinical analysis of a pedigree affected with X-linked dominant Alport syndrome due to a novel variant of COL4A5 gene].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):461-464

Center of Genetic and Prenatal Diagnosis, Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Objective: To explore the genetic basis for a Chinese pedigree affected with X-linked hereditary Alport syndrome.

Methods: Next generation sequencing was carried out for the pedigree. Candidate variant was validated by Sanger sequencing. Pathological changes of renal basement membrane and expression of COL4A5 protein were analyzed by renal biopsy and immunofluorescence assay, respectively.

Results: All patients from the pedigree manifested progressive renal damage, gross hematuria, proteinuria and nephrotic syndrome. Renal biopsy of the proband revealed thickening of the basement membrane. No expression of the COL4A5 gene was detected by immunofluorescence. High-throughput sequencing and Sanger sequencing indicated that the proband has carried a c.3706delC (p.1236Pfs*69) variant in exon 41 of the COL4A5 gene. The same variant was also found in his mother and two brothers whom were similarly affected.

Conclusion: The novel c.3706delC (p.1236Pfs*69) variant of the COL4A5 gene probably underlay the pathogenesis of X-linked hereditary Alport syndrome in this pedigree. Above findings have enriched the spectrum of COL4A5 gene variants and provided a basis for the diagnosis and genetic counseling for the pedigree.
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http://dx.doi.org/10.3760/cma.j.cn511374-20200607-00415DOI Listing
May 2021

A Novel Prognostic Model and Practical Nomogram for Predicting the Outcomes of Colorectal Cancer: Based on Tumor Biomarkers and Log Odds of Positive Lymph Node Scheme.

Front Oncol 2021 16;11:661040. Epub 2021 Apr 16.

State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: Emerging evidence shows that serum tumor biomarkers (TBs) and log odds of positive lymph node scheme (LODDS) are closely associated with the prognosis of colorectal cancer (CRC) patients. The aim of our study is to validate the predictive value of TBs and LODDS clinically and to develop a robust prognostic model to predict the overall survival (OS) of patients with CRC.

Methods: CRC patients who underwent radical resection and with no preoperative chemotherapy were enrolled in the study. The eligible population were randomized into training (70%) and test (30%) cohorts for the comprehensive evaluation of the prognostic model. Clinical implications of serum biomarkers and LODDS were identified by univariate and multivariate Cox proportion regression analysis. The predictive ability and discriminative performance were evaluated by Kaplan-Meier (K-M) curves and receiver operating characteristic (ROC) curves. Clinical applicability of the prognostic model was assessed by decision curve analysis (DCA), and the corresponding nomogram was constructed based on the above factors.

Results: A total of 1,202 eligible CRC patients were incorporated into our study. Multivariable COX analysis demonstrated that CA199 (HR = 1.304), CA125 (HR = 1.429), CEA (HR = 1.307), and LODDS (HR = 1.488) were independent risk factors for OS (all P < 0.0001). K-M curves showed that the high-risk group possessed a shorter OS than the low-risk counterparts. The area under curves (AUCs) of the model for 1-, 3- and 5-year OS were 86.04, 78.70, and 76.66% respectively for the train cohort (80.35, 77.59, and 74.26% for test cohort). Logistic DCA and survival DCA confirmed that the prognostic model displayed more clinical benefits than the conventional AJCC 8 TNM stage and CEA model. The nomograms were built accordingly, and the calibration plot for the probability of survival at 3- or 5-years after surgery showed an optimal agreement between prediction and actual observation.

Conclusions: Preoperative serum TBs and LODDS have significant clinical implications for CRC patients. A novel prognostic model incorporating common TBs (CA199, CA125, and CEA) and LODDS displayed better predictive performance than both single factor and the TNM classification. A novel nomogram incorporating TBs and LODDS could individually predict OS in patients with CRC.
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http://dx.doi.org/10.3389/fonc.2021.661040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085421PMC
April 2021

Photostable AIE probes for wash-free, ultrafast, and high-quality plasma membrane staining.

J Mater Chem B 2021 Jun;9(21):4303-4308

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, P. R. China.

Plasma membrane (PM), a fundamental building component of a cell, is responsible for a variety of cell functions and biological processes. However, it is still challenging to acquire its morphology and morphological variation information via an effective approach. Herein, we report a PM imaging study regarding an aggregation-induced emission luminogen (AIEgen) called tetraphenylethylene-naphthalimide+ (TPE-NIM+), which is derived from our previously reported tetraphenylethylene-naphthalimide (TPE-NIM). The designed AIEgen (TPE-NIM+) shows significant characteristics of ultrafast staining, high photostability, wash-free property, and long retention time at the PM, which can structurally be correlated with its positively charged quaternary amine and hydrophobic moiety. TPE-NIM+ is further applied for staining of different cell lines, proving its universal PM imaging capability. Most importantly, we demonstrate that TPE-NIM+ can clearly delineate the contours of densely packed living cells with high cytocompatibility. Therefore, TPE-NIM+ as a PM imaging reagent superior to currently available commercial PM dyes shall find a number of applications in the biological/biomedical fields and even beyond.
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http://dx.doi.org/10.1039/d1tb00049gDOI Listing
June 2021

Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF.

Cancer Manag Res 2021 12;13:3155-3169. Epub 2021 Apr 12.

Department of Pathology, Ningxia Medical University, Yinchuan City, Ningxia Province, 750004, People's Republic of China.

Purpose: Gastric cancer (GC) is one of the most fatal digestive tumors worldwide. Abnormal activation or accumulation of the nuclear factor-erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) axis is a malignant event in numerous solid tumors. However, its involvement in angiogenesis of GC remains unknown. This study investigated the role of the Nrf2/HO-1 axis in angiogenesis of GC.

Methods: The expression of Nrf2, HO-1, and vascular endothelial growth factor (VEGF) in BGC-823 cells under hypoxia was analyzed using immunocytochemistry, immunofluorescence, Western blotting, and quantitative polymerase chain reaction. The effects of brusatol (Nrf2 inhibitor) and tert-butylhydroquinone (Nrf2 inducer) on these factors and angiogenesis were examined using immunofluorescence, Western blotting, quantitative polymerase chain reaction, and tube formation assay. Moreover, immunohistochemistry and Western blotting were used to determine these factors and microvessel density in tumor and normal tissues of tumor-bearing and tumor-free mice, respectively. Immunohistochemistry and Western blotting were employed to examine these factors and microvessel density in human paracancerous tissues, well-differentiated GC, and poorly differentiated GC. The correlations between Nrf2, HO-1, and VEGF gene expression in 375 patients with GC from The Cancer Genome Atlas cohort were analyzed.

Results: The expression of Nrf2, HO-1, and VEGF was increased in hypoxic BGC-823 cells (<0.05). Although brusatol decreased their expression and angiogenesis (<0.05), tert-butylhydroquinone had the opposite effect (<0.05). Moreover, the expression of Nrf2, HO-1, and VEGF, and microvessel density in tumor tissues was higher than that recorded in normal tissues of nude mice (<0.05). Similarly, these parameters were low in paracancerous tissues, but high in GC tissues (<0.05). Also, they were weak in well-differentiated GC, but strong in poorly differentiated GC (<0.05). In addition, there was a significant correlation between Nrf2, HO-1, and VEGF (<0.05).

Conclusion: The Nrf2/HO-1 axis may regulate the angiogenesis of GC via targeting VEGF. These findings provide a promising biomarker and potential treatment target for GC.
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http://dx.doi.org/10.2147/CMAR.S292461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055645PMC
April 2021

[Astragaloside Ⅳ's Therapeutic Effect on Myocardial Infarction via Affecting Autophagy and the Mechanism Study].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):222-228

Department of Internal Medicine-Cardiovascular, General Hospital of Ningxia Medical University, Yinchuan 750004, China.

Objective: The purpose of this study was to investigate the protective effect of astragaloside Ⅳ (AS-Ⅳ) on neonatal rats' hypoxic/reoxygenated (H/R) injured myocardial cells and to explore its underlying mechanism.

Methods: Cardiac cells were extracted from newborn rats and divided into control, H/R, H/R-low AS-Ⅳ (0.1 μmol/L AS-Ⅳ), H/R-medium AS-Ⅳ (1 μmol/L AS-Ⅳ), H/R-high AS-Ⅳ (10 μmol/L AS-Ⅳ) and H/R-high AS-Ⅳ-AKT (10 μmol/L AS-Ⅳ+5 μmol/L AKT) groups. After 48 h of treatment, the contents of LC3-Ⅱ, p62, AKT, pAKT, rapamycin (mTOR) mammalian targets and uncoordinated 51-like kinase 1 (ULK1) in cardiac myocytes were compared. Immunofluorescence staining was used to detect the expression of P62 in myocardium autophagosome.

Restults: AS-Ⅳ improved the proliferative activity of cardio AS-Ⅳ improved the proliferative activity of cardiomyocytes in H/R injury in a dose-dependent manner and inhibited the level of cell autophagy. However, when AKT inhibitors were added, the effect of AS-Ⅳ was partially inhibited ( <0.05). Gene and protein expression showed that AS-Ⅳ had no significant effect on the expression of AKT and mTOR genes ( >0.05), but could significantly promote the phosphorylation of AKT and mTOR ( <0.05). Immunofluorescence staining results showed that high concentrations of the AS - Ⅳ can reverse H/R injury induced the expression of autophagy body P62.

Conclusion: AS-Ⅳ showed protection effect on H/R injured myocardial cells. The possible mechanism is by reducing the autophagy level via activating the mTOR signal in the PI3K/AKT pathway, thereby preventing H/R damage in neonatal rat cardiomyocytes.
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http://dx.doi.org/10.12182/20201260601DOI Listing
March 2021

Distinguishing Planting Structures of Different Complexity from UAV Multispectral Images.

Sensors (Basel) 2021 Mar 12;21(6). Epub 2021 Mar 12.

College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling 712100, China.

This study explores the classification potential of a multispectral classification model for farmland with planting structures of different complexity. Unmanned aerial vehicle (UAV) remote sensing technology is used to obtain multispectral images of three study areas with low-, medium-, and high-complexity planting structures, containing three, five, and eight types of crops, respectively. The feature subsets of three study areas are selected by recursive feature elimination (RFE). Object-oriented random forest (OB-RF) and object-oriented support vector machine (OB-SVM) classification models are established for the three study areas. After training the models with the feature subsets, the classification results are evaluated using a confusion matrix. The OB-RF and OB-SVM models' classification accuracies are 97.09% and 99.13%, respectively, for the low-complexity planting structure. The equivalent values are 92.61% and 99.08% for the medium-complexity planting structure and 88.99% and 97.21% for the high-complexity planting structure. For farmland with fragmentary plots and a high-complexity planting structure, as the planting structure complexity changed from low to high, both models' overall accuracy levels decreased. The overall accuracy of the OB-RF model decreased by 8.1%, and that of the OB-SVM model only decreased by 1.92%. OB-SVM achieves an overall classification accuracy of 97.21%, and a single-crop extraction accuracy of at least 85.65%. Therefore, UAV multispectral remote sensing can be used for classification applications in highly complex planting structures.
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http://dx.doi.org/10.3390/s21061994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000794PMC
March 2021

Capacity of a Radio Vortex Communication System Using a Partial Angular Aperture Receiving Scheme under the Horizontal Non-Kolmogorov Model.

Sensors (Basel) 2021 Mar 4;21(5). Epub 2021 Mar 4.

School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.

A partial receiving scheme based on limited angular aperture multi-beam receiving and demultiplexing can solve the difficulty caused by the divergence of the vortex beam in the conventional whole beam receiving scheme and realize the long-distance transmission of the vortex wave. The propagation of the radio vortex beam in atmospheric turbulence is of significant importance in theoretical study and practical applications. In this paper, the influence of atmospheric turbulence on the performance of a radio vortex (RV) communication system based on a partial angular aperture receiving (PAAR) scheme under the horizontal non-Kolmogorov channel model is studied. The spiral spectrum of the PAAR scheme and the channel capacity of the RV communication system using the PAAR scheme are derived. Simulation results demonstrate that the selected transmission frequency range has a great influence on the RV communication system based on the PAAR scheme, and the choice of the orbital angular momentum (OAM) mode number L has an influence on the propagation distance. The capacity of RV communication systems based on the PAAR scheme increases with the increase of the transmission frequency in the selected transmission frequency range of 10 GHz-60 GHz. When the number of orbital angular momentum (OAM) modes L is small, we can improve the signal-to-noise ratio (SNR) to obtain a larger capacity of the RV communication system based on the PAAR scheme over a longer propagation distance.
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http://dx.doi.org/10.3390/s21051778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961971PMC
March 2021

Neutrophil/Lymphocyte Ratio as an Inflammatory Predictor of Dry Eye Disease: A Case-Control Study.

Ther Clin Risk Manag 2021 23;17:259-266. Epub 2021 Mar 23.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as indicators of inflammation, however, their roles in dry eye disease (DED) patients require advanced study.

Materials And Methods: A total of 104 DED cases and 97 healthy controls from January 2020 to May 2020 were enrolled in this study. The dry eye related clinical variables, including Schirmer I test, tear break-up time (TBUT), corneal fluorescein staining (CFS) and Ocular Surface Disease Index (OSDI), were detected in all the participants. Besides, the NLR and PLR pattern in DED cases were detected and their potential value as inflammatory predictors of DED were evaluated. In advanced analyses, the correlation between NLR and DED severity was examined.

Results: The NLR and PLR were 2.59 ± 1.25 and 117.48 ± 54.68 in the DED group, respectively, while they were 2.20 ± 1.24 and 115.48 ± 54.33 in the control group, respectively. The NLR was higher in the DED group ( = 0.027), however, PLR was not significantly different compared with the control group ( = 0.951). In advanced analyses, it was found that more severe TBUT, CFS, and OSDI scores were detected in the high NLR group (NLR ≥2.145, = 0.003, 0.013, and 0.017, respectively) compared with the low NLR group (NLR <2.145).

Conclusion: The NLR value, but not PLR, of DED patients was higher than that of healthy controls. The NLR could be used as an inflammatory predictor to estimate the severity of DED.
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http://dx.doi.org/10.2147/TCRM.S298156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001663PMC
March 2021

Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study.

Front Neurol 2021 4;12:615230. Epub 2021 Mar 4.

Department of Neurolgoy, People's Hospital of Zhengzhou University, Zhengzhou, China.

We investigated the risk factors for death in patients with medullary infarction (MI) during a long-term follow-up. We retrospectively examined 179 consecutive patients (130 men and 49 women) who had clinical and MRI findings consistent with MI between February 2012 and January 2017 at three university hospitals. Long-term outcomes were assessed by telephonic interview. The clinical and radiological features and risk factors for poor outcomes (modified Rankin scale score ≥ 3, all-cause death) were analyzed. Mean age of patients was 58.3 ± 12.8 years (range, 25-87); mean follow-up period after stroke onset was 42.7 ± 13.2 months (range, 24-78). Basilar artery (BA) stenosis >50% was more closely related to medial medullary infarction (MMI) than other types. There was greater frequency of ipsilateral vertebral artery hypoplasia (VAH) or V4AH and V4 occlusion in lateral MI than in other types. On rostro-caudal classification, middle (M)+dorsal (D) was most frequent, followed by the ventral (V)+M+D types. 21.2% patients showed poor long-term prognosis. Age ≥ 65 years, recurrent stroke, dysphagia, >50% BA stenosis, and ventral MI were risk factors for poor long-term prognosis. All-cause mortality rate was 10.6%; age ≥ 65 years, recurrent stroke, and dysphagia were risk factors for death in the long-term. Ventral MI and MMI+cerebellar infarction, as well as stroke mechanism of artery-to-artery embolism, were potential risk factors for death in the long-term. Pneumonia and recurrent stroke were major causes of death. Long-term poor outcomes of MI and all-cause mortality were not infrequent. Older age, recurrent stroke, and dysphagia were common risk factors for poor prognosis and death.
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http://dx.doi.org/10.3389/fneur.2021.615230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969705PMC
March 2021