Qi-En Wang

Qi-En Wang

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Qi-En Wang

Qi-En Wang

Publications by authors named "Qi-En Wang"

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Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis.

PLoS One 2019 15;14(5):e0216553. Epub 2019 May 15.

Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519829PMC
May 2019

Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library.

J Am Chem Soc 2018 09 11;140(38):12102-12110. Epub 2018 Sep 11.

Department of Chemistry and Biochemistry , The Ohio State University , 100 West 18th Avenue , Columbus , Ohio 43210 , United States.

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http://dx.doi.org/10.1021/jacs.8b06738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231237PMC
September 2018

Core signaling pathways in ovarian cancer stem cell revealed by integrative analysis of multi-marker genomics data.

PLoS One 2018 3;13(5):e0196351. Epub 2018 May 3.

Department of BioMedical Informatics (BMI), The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196351PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933740PMC
August 2018

NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway.

Am J Transl Res 2018 15;10(6):1713-1721. Epub 2018 Jun 15.

Oncology Center, Zhujiang Hospital, Southern Medical University Guangzhou 510282, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038089PMC
June 2018

Depleting ovarian cancer stem cells with calcitriol.

Oncotarget 2018 Mar 16;9(18):14481-14491. Epub 2018 Feb 16.

Department of Radiology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.18632/oncotarget.24520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865684PMC
March 2018

UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair.

Carcinogenesis 2017 10;38(10):976-985

Department of Radiology.

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http://dx.doi.org/10.1093/carcin/bgx076DOI Listing
October 2017

DDB2 increases radioresistance of NSCLC cells by enhancing DNA damage responses.

Tumour Biol 2016 Oct 23;37(10):14183-14191. Epub 2016 Aug 23.

Department of Radiology, Division of Radiobiology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s13277-016-5203-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528175PMC
October 2016

Rad51C-ATXN7 fusion gene expression in colorectal tumors.

Mol Cancer 2016 06 13;15(1):47. Epub 2016 Jun 13.

Comprehensive Cancer Center, the Ohio State University College of Medicine and Public Health, Columbus, Ohio, 43210, USA.

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http://dx.doi.org/10.1186/s12943-016-0527-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906819PMC
June 2016

Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy.

Mol Cell Oncol 2016 Jan-Feb;3(1):e1043482. Epub 2015 Jun 2.

Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1080/23723556.2015.1043482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845331PMC
June 2016

The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.

J Biol Chem 2016 May 18;291(20):10847-57. Epub 2016 Mar 18.

From the Georgia Cancer Center and Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912,

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http://dx.doi.org/10.1074/jbc.M115.713099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865929PMC
May 2016

miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.

Tumour Biol 2016 Apr 18;37(4):5645-51. Epub 2015 Nov 18.

Department of Radiology, The Ohio State University Wexner Medical Center, Room 1014, 460 W. 12th Ave, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s13277-015-4328-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528179PMC
April 2016

Differential DNA lesion formation and repair in heterochromatin and euchromatin.

Carcinogenesis 2016 Feb 30;37(2):129-38. Epub 2015 Dec 30.

Department of Radiology and James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

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http://dx.doi.org/10.1093/carcin/bgv247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006209PMC
February 2016

Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair.

Cell Cycle 2015 ;14(7):1103-15

a Department of Radiology ; The Ohio State University Wexner Medical Center ; Columbus , OH USA.

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http://dx.doi.org/10.4161/15384101.2014.973740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614405PMC
December 2015

TGFβ Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response.

Cancer Res 2015 Dec 2;75(24):5273-82. Epub 2015 Dec 2.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio. The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681611PMC
December 2015

DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L.

Nucleic Acids Res 2015 Sep 29;43(16):7838-49. Epub 2015 Jun 29.

Division of Radiobiology, Department of Radiology, The Ohio State University Medical Center, Columbus, OH 43210, USA Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

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http://dx.doi.org/10.1093/nar/gkv667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652750PMC
September 2015

DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies.

Authors:
Qi-En Wang

World J Biol Chem 2015 Aug;6(3):57-64

Qi-En Wang, Division of Radiobiology, Department of Radiology, the Ohio State University, Wexner Medical Center, Columbus, OH 43210, United States.

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http://dx.doi.org/10.4331/wjbc.v6.i3.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549769PMC
August 2015

TGF-β signaling and its targeting for glioma treatment.

Am J Cancer Res 2015 15;5(3):945-55. Epub 2015 Feb 15.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University Columbus, Ohio 43210, USA ; The Ohio State University Comprehensive Cancer Center Columbus, Ohio 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449428PMC
June 2015

Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2.

Mutat Res 2015 Jun 24;776:16-23. Epub 2015 Jan 24.

Department of Radiology, The Ohio State University, Columbus, OH 43210, United States; Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, United States; James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053336PMC
http://dx.doi.org/10.1016/j.mrfmmm.2015.01.005DOI Listing
June 2015

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

Cell Cycle 2014 24;13(1):106-14. Epub 2013 Oct 24.

Department of Radiology; The Ohio State University; Columbus, OH USA; Department of Molecular and Cellular Biochemistry; The Ohio State University; Columbus, OH USA; James Cancer Hospital and Solove Research Institute; The Ohio State University; Columbus, OH USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.26814
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http://dx.doi.org/10.4161/cc.26814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925719PMC
September 2014

Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.

J Biol Chem 2014 Sep 12;289(39):27278-89. Epub 2014 Aug 12.

From the Department of Radiology, Department of Molecular and Cellular Biochemistry, and James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210

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http://dx.doi.org/10.1074/jbc.M114.589812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175359PMC
September 2014

Genetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.

Clin Cancer Res 2014 Aug 27;20(15):3989-4000. Epub 2014 Mar 27.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119545PMC
August 2014

DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer.

Mol Cancer Res 2014 May 26;12(5):784-94. Epub 2014 Feb 26.

Authors' Affiliations: Departments of Radiology and 2Pathology; 3Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio; and 4Weifang Medical University, Shandong, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096129PMC
May 2014

Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis.

PLoS One 2013 1;8(7):e67033. Epub 2013 Jul 1.

Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067033PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698186PMC
February 2014

Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.

PLoS One 2013 13;8(2):e55934. Epub 2013 Feb 13.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055934PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572185PMC
August 2013

DKK3 is a potential tumor suppressor gene in papillary thyroid carcinoma.

Endocr Relat Cancer 2013 Aug 27;20(4):507-14. Epub 2013 Jun 27.

Department of Thyroid Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People's Republic of China.

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http://dx.doi.org/10.1530/ERC-13-0053DOI Listing
August 2013

p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair.

Nucleic Acids Res 2013 Feb 28;41(3):1722-33. Epub 2012 Dec 28.

Department of Radiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks1312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561975PMC
February 2013

Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2.

Cancer Res 2012 Feb 15;72(3):666-75. Epub 2011 Dec 15.

Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595572PMC
February 2012

Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment.

Mutat Res 2011 Mar 15;708(1-2):59-68. Epub 2011 Feb 15.

Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00275107110002
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http://dx.doi.org/10.1016/j.mrfmmm.2011.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091508PMC
March 2011

Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex.

J Biol Chem 2009 Oct 8;284(44):30424-32. Epub 2009 Sep 8.

Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M109.044982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781597PMC
October 2009

[Inhibitory mechanisms of three compounds for chrysotile-induced biological activities].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008 Oct;26(10):592-5

China Academy of Safety Sciences and Technology, Beijing 100029, China.

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October 2008

Role of Claspin in regulation of nucleotide excision repair factor DDB2.

DNA Repair (Amst) 2007 May 28;6(5):578-87. Epub 2006 Dec 28.

Department of Radiology, The Ohio State University, Columbus, OH 43240, United States.

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http://dx.doi.org/10.1016/j.dnarep.2006.11.009DOI Listing
May 2007

Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

J Biol Chem 2006 May 8;281(19):13404-11. Epub 2006 Mar 8.

Department of Radiology, The Ohio State University, Columbus, Ohio 43210-1000, USA.

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http://dx.doi.org/10.1074/jbc.M511834200DOI Listing
May 2006

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells.

Int J Cancer 2005 Nov;117(3):409-17

Department of Radiology, Ohio State University, Columbus, OH 43210, USA.

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http://doi.wiley.com/10.1002/ijc.21205
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http://dx.doi.org/10.1002/ijc.21205DOI Listing
November 2005

Deubiquitination by proteasome is coordinated with substrate translocation for proteolysis in vivo.

Exp Cell Res 2005 Jul;307(2):436-51

Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.yexcr.2005.03.031DOI Listing
July 2005

DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation.

Nucleic Acids Res 2005 19;33(13):4023-34. Epub 2005 Jul 19.

Department of Radiology, The Ohio State University 103 Wiseman Hall, 400 W. 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/nar/gki684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1178000PMC
July 2005

Cellular ubiquitination and proteasomal functions positively modulate mammalian nucleotide excision repair.

Mol Carcinog 2005 Jan;42(1):53-64

Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA.

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http://doi.wiley.com/10.1002/mc.20065
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http://dx.doi.org/10.1002/mc.20065DOI Listing
January 2005

UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.

Carcinogenesis 2004 Jun 23;25(6):1033-43. Epub 2004 Jan 23.

Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/carcin/bgh085DOI Listing
June 2004

The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain.

FEBS Lett 2004 Jan;556(1-3):19-25

Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/s0014-5793(03)01347-4DOI Listing
January 2004

Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage.

DNA Repair (Amst) 2003 May;2(5):483-99

Department of Radiology, The Ohio State University, 103 Wiseman Hall, 400 W. 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/s1568-7864(03)00002-8DOI Listing
May 2003

[Detection of cell apoptosis induced with anti-Fas antibody in bladder carcinoma cell line by single cell gel electrophoresis].

Ai Zheng 2002 Jan;21(1):45-9

Daxing Male Hospital, Wu Jieping's Medical Foundation, Beijing 102600, P. R. China.

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January 2002