Publications by authors named "Qi Wei"

865 Publications

Isolation and Molecular Identification of the Native Microflora on Fruiting Bodies and Modeling the Growth of Dominant Microbiota ().

Front Microbiol 2021 21;12:664874. Epub 2021 May 21.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.

The objectives of this study were to isolate and identify the dominant microorganism in fruiting bodies (FVFB) and to develop kinetic models for describing its growth. The native microflora community on FVFB was isolated and identified using morphological examination and high-throughput sequencing analysis. FVFB presented complex microbial communities with dominant microorganisms being Irradiated FVFB were inoculated with the isolated strain of and cultivated at various temperatures (4, 10, 16, 20, 25, 32, and 37°C). Three primary models, namely the Huang, Baranyi and Roberts, and reparameterized Gompertz models, and three secondary models, namely the Huang square-root, Ratkowsky square-root, and Arrhenius-type models, were developed and evaluated. With the lowest values of mean square error (MSE, 0.023-0.161) and root mean square error (RMSE, 0.152-0.401) values, the reparameterized Gompertz model was more suitable to describe the growth of on FVFB than both Huang and Baranyi and Roberts models. The Ratkowsky square-root model provided more accurate estimation for the effect of temperature on the specific growth rate of . The minimum growth temperature predicted by the Ratkowsky square-root model was -7.1°C. The kinetic models developed in this study could be used to evaluate the growth behavior of on FVFB and estimate the shelf-life of FVFB.
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http://dx.doi.org/10.3389/fmicb.2021.664874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176924PMC
May 2021

Assessment of the efficacy of tuina on treating cervicogenic headache: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(22):e26224

Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun.

Background: Cervicogenic headache is a secondary headache characterized by unilateral headache, symptoms, and signs of neck involvement. It is often worsened by neck movement, sustained awkward head position, or external pressure over the upper cervical or occipital region on the symptomatic side. In this systematic review, we aimed to evaluate the efficacy and safety of massage therapy for the treatment of cervicogenic headache.

Methods: We searched the China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, China Doctoral Dissertations Full-Text Database, China Master's Theses Full-Text Database, Cochrane Central Register of Controlled Trials, PubMed, and Embase. We will select all eligible studies published on or before April 1, 2021. We will use Review Manager 5.4, provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures.

Results: This meta-analysis further confirmed the benefits of tuina in the treatment of cervicogenic headache.

Conclusion: The purpose of this meta-analysis was to explore the effect of tuina on patients with cervicogenic headache and to provide more options for clinicians and patients to treat cervicogenic headache.

Ethics And Dissemination: This systematic review will evaluate the efficacy and safety of tuina in the treatment of cervicogenic headache. Since all the data included were published, the systematic review did not require ethical approval.

Registration Number: INPLASY202150053.
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http://dx.doi.org/10.1097/MD.0000000000026224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183763PMC
June 2021

Retinal toxicity caused by hydroxychloroquine in patients with systemic lupus erythematosus: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e25688

Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou.

Rationale: Hydroxychloroquine has excellent anti-inflammatory and immunomodulatory effects as one of the antimalarial drugs. In particular, hydroxychloroquine was once widely used as a treatment for the new coronavirus pneumonia epidemic in 2020. Retinopathy caused by hydroxychloroquine is normally irreversible, but little attention has been paid to it.

Patient Concerns: A 38-year-old young Chinese woman was taking oral hydroxychloroquine 400 mg daily to control lupus disease activity for six years after the diagnosis of systemic lupus erythematosus (SLE). She did not have any history of eye disease and was admitted to the hospital with a sudden blurring of both eyes.

Diagnoses: The diagnosis of retinal macular degeneration caused by hydroxychloroquine was made after excluding other interfering diseases based on the patient's long-term use of hydroxychloroquine and the results of the eye examination.

Interventions: The patient was discontinued from hydroxychloroquine. To control the recurrence of SLE, she was given intravenous methylprednisolone, oral tacrolimus and mycophenolate. Meanwhile, she was asked to take extra care of her eyes and to come to the hospital every three months to have her vision checked.

Outcomes: The patient's blurred vision improved one week later. Three months later, her vision examination showed no further decline (0.4 in the right eye and 0.6 in the left eye). Meanwhile, the SLE disease activity index (SLEDAI) decreased from six points to five points currently.

Lessons: Retinopathy caused by hydroxychloroquine is irreversible and there is no particularly effective treatment. Discontinuation of hydroxychloroquine, better daily eye protection, and regular vision checks are the keys to preventing retinopathy. Although hydroxychloroquine causing retinal toxicity was mentioned several years ago, the rate and severity of retinal toxicity require further research. How to get more patients to take care of their eyes requires continuous and increased education by doctors.
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http://dx.doi.org/10.1097/MD.0000000000025688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183791PMC
June 2021

Enhanced electrochemical performance of MnO nanoparticles: graphene aerogels as conductive substrates and capacitance contributors.

Dalton Trans 2021 Jun 4. Epub 2021 Jun 4.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

An N-doped graphene aerogel (NGA) is used as a reactive container for growing MnO2 nanoparticles via a soaking-hydrothermal strategy. MnO2 nanoparticles pile up on the surface of reduced graphene oxide sheets with crosslinked structures serving as electrical conductors. Importantly, the NGA generates extra capacitance during the electrochemical process, which accomplishes a satisfactory compensation in the physical-chemical properties of MnO2. As a cathodic electrode for Zn-ion batteries, the MnO2/NGA exhibits a specific capacity of 275.8 mA h g-1 and pre-eminent cycling stability with a retention of 93.6% at 3 A g-1 after 1000 cycles. Meanwhile, the proposed electrode also shows a relatively high specific capacitance of 341 F g-1 for a supercapacitor in 1 M Na2SO4. Meanwhile, the long-term cycling stability shows only a slight decrease by 5.1% of the initial capacitance after 5000 continuous cycles at 3 A g-1, which indicates its superior electrochemical stability. Additionally, the assembled asymmetric supercapacitor also shows good electrochemical performance. This work highlights the extensive function of an N-doped graphene aerogel as a promising substrate for enhancing the electrochemical performance of MnO2, which opens the gate for wide potential applications of graphene aerogel composites emphasizing their complementary effects.
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http://dx.doi.org/10.1039/d1dt00404bDOI Listing
June 2021

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double-Blind, Dose Escalation, Placebo- and Positive-Controlled, Phase 1/2 Trial.

Adv Sci (Weinh) 2021 Jun 3:e2002751. Epub 2021 Jun 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

Tetanus is a fatal but vaccine-preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)-based. Although these vaccines are generally effective, challenges in vaccine development and access remain. A randomized, double-blind, dose escalation, placebo- and positive-controlled, phase 1/2 trial (ChiCTR1800015865) is performed to evaluate the safety and immunogenicity of an alternative recombinant tetanus vaccine based on the Hc domain of tetanus neurotoxin (TeNT-Hc) in healthy adult volunteers. The primary outcome is the safety profile of the recombinant tetanus vaccine, and immunogenicity is the secondary outcome. 150 eligible participants were enrolled and randomly assigned to receive one of the three doses of recombinant tetanus vaccine (TeNT-Hc 10/20/30 µg), TT vaccine, or placebo. The recombinant tetanus vaccine shows a good safety profile. The frequency of any solicited and unsolicited adverse events after each vaccination does not differ across the vaccine and placebo recipients. No serious treatment-related adverse events occur. The recombinant tetanus vaccine shows strong immune responses (seroconversion rates, geometric mean titer, and antigen-specific CD4+/CD8+ T-cell responses), which are roughly comparable to those of the TT vaccine. In conclusion, the findings from this study support that recombinant tetanus vaccine is safe and immunogenic; thereby, it represents a novel vaccine candidate against tetanus.
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http://dx.doi.org/10.1002/advs.202002751DOI Listing
June 2021

Microfluidic Synthesis of Lignin/Chitosan Nanoparticles for the pH-Responsive Delivery of Anticancer Drugs.

Langmuir 2021 Jun 2. Epub 2021 Jun 2.

Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.

In this work, lignin/chitosan nanoparticles (Lig/Chi NPs) with controlled structures were synthesized in a simple and scalable microfluidic system. When the positively charged chitosan and the negatively charged lignin solution were blended in a microreactor, Lig/Chi NPs were rapidly formed via the electrostatic coassembly between the amino groups of chitosan and the carboxyl groups of lignin. The ζ potential changes from negative (-13 mV) to positive (+54.5 mV) for Lig NPs and Lig/Chi NPs, respectively. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) results demonstrated that Lig/Chi NPs have an average particle size of about 180 nm, which can be used as nanocarriers for drug delivery. The anticancer drug nanoparticles with docetaxel (DTX) and curcumin (CCM) were prepared by coassembly with Lig/Chi NPs in a microreactor, which had good drug loading efficiency, biocompatibility, and can release drugs in response to pH in the weakly acidic environment of the tumor. The drug release amounts in acidic solutions that simulated the tumor microenvironment were 51% ([email protected]/Chi NPs) and 50% ([email protected]/Chi NPs), respectively, which were better than the release amounts at pH 7.4, and have an obvious killing effect on HeLa cells.
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http://dx.doi.org/10.1021/acs.langmuir.1c00778DOI Listing
June 2021

The Preparation of a Novel Poly(Lactic Acid)-Based Sustained HS Releasing Microsphere for Rheumatoid Arthritis Alleviation.

Pharmaceutics 2021 May 18;13(5). Epub 2021 May 18.

State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China.

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that mainly erodes joints and surrounding tissues, and if it is not treated in time, it can cause joint deformities and loss of function. S-propargyl-cysteine (SPRC) is an excellent endogenous hydrogen sulfide donor which can relieve the symptoms of RA through the promotion of HS release via the CSE/HS pathway in vivo. However, the instant release of HS in vivo could potentially limit its further clinical use. To solve this problem, in this study, a SPRC-loaded poly(lactic acid) (PLA) microsphere ([email protected]) was prepared, which could release SPRC in vitro in a sustained manner, and further promote sustained in vivo HS release. Furthermore, its therapeutical effect on RA in rats was also studied. A spherical-like [email protected] was successfully prepared with a diameter of approximately 31.61 μm, yielding rate of 50.66%, loading efficiency of 6.10% and encapsulation efficiency of 52.71%. The [email protected] showed significant prolonged in vitro SPRC release, to 4 days, and additionally, an in vivo HS release around 3 days could also be observed. In addition, a better therapeutical effect and prolonged administration interval toward RA rats was also observed in the [email protected] group.
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http://dx.doi.org/10.3390/pharmaceutics13050742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157395PMC
May 2021

Measuring fluence distribution of intense short laser based on the radiochromic effect.

Opt Lett 2021 Jun;46(11):2795-2798

This Letter demonstrates a novel, to the best of our knowledge, method to measure the fluence distribution of an intense short laser pulse based on the radiochromic effect. We discovered that an intense short laser pulse can induce the color reaction with a radiochromic film (RCF). Further, the net optical density of an irradiated RCF is proportional to the fluence of the incident laser pulse in a large range (${2 {-} 120}\;{{{\rm mJ}/{\rm cm}}^2}$). This method supports a large detection area up to near square-meter scale by splicing multi-pieces of RCFs (${8} \times 10\;{{\rm inch}^2}$ each). The spatial resolution reaches as high as 60 lines/mm. It offers a thin-film (${\sim}{100}\;{\unicode{x00B5}{\rm m}}$ thick), flexible, vacuum-compatible solution to intense short laser measurements, especially to laser facilities above petawatt, with beam sizes up to near square-meter scale, e.g., extreme light infrastructure.
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http://dx.doi.org/10.1364/OL.424698DOI Listing
June 2021

A novel dendritic mesoporous silica based sustained hydrogen sulfide donor for the alleviation of adjuvant-induced inflammation in rats.

Drug Deliv 2021 Dec;28(1):1031-1042

State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Taipa, China.

Purpose: S-propargyl-cysteine (SPRC), an excellent endogenous hydrogen sulfide (HS) donor, could elevate HS levels via the cystathionine γ-lyase CSE)/HS pathway both and . However, the immediate release of HS and daily administration of SPRC potentially limited its clinical use.

Methods: To solve the fore-mentioned problem, in this study, the dendritic mesoporous silica nanoparticles (DMSN) was firstly prepared, and a sustained HS delivery system consisted of SPRC and DMSN ([email protected]) was then constructed. Their release profiles, both and , were investigated, and their therapeutical effect toward adjuvant-induced arthritis (AIA) rats was also studied.

Results: The spherical morphology of DMSN could be observed under scanning Electron Microscope (SEM), and the transmission electron microscope (TEM) images showed a central-radiational pore channel structure of DMSN. DMSN showed excellent SPRC loading capacity and attaining a sustained releasing ability than SPRC both and , and the prolonged SPRC releasing could further promote the release of HS in a sustained manner through CSE/HS pathway both and . Importantly, the [email protected] showed promising anti-inflammation effect against AIA in rats was also observed.

Conclusions: A sustained HS releasing donor consisting of SPRC and DMSN was constructed in this study, and this sustained HS releasing donor might be of good use for the treatment of AIA.
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http://dx.doi.org/10.1080/10717544.2021.1921075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172227PMC
December 2021

Self-Templated, Enantioselective Assembly of an Amyloid-like Dipeptide into Multifunctional Hierarchical Helical Arrays.

ACS Nano 2021 May 28. Epub 2021 May 28.

School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, People's Republic of China.

Chiral self-assembly of peptides has attracted great interest owing to their promising applications in biomedicine, chemistry, and materials science. However, compared with the rich knowledge about their chiral self-assembly at the molecular or nanoscale, the formation of long-range-ordered hierarchical helical arrays (HHAs) from simple peptides remains a formidable challenge. Herein, we report the self-templated assembly of an amyloid-like dipeptide into long-range-ordered HHAs by their spontaneous fibrillization and hierarchical helical assembly within a confined film. The chiral interactions between the peptide and diamines result in geometry frustration and the phase transition of self-assembling peptide films from achiral spherulite structures into chiral HHAs. By changing the chirality and enantioselective interactions, we can control the phase behavior, handedness, and chiroptics of the self-assembled HHAs precisely. Moreover, the redox activity of the HHAs allows the decoration of nanoparticles with high catalytic activity. These results provide insights into the chiral self-assembly of peptides and the fabrication of highly ordered materials with complex architectures and promising applications in chiroptics and catalysis.
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http://dx.doi.org/10.1021/acsnano.1c00746DOI Listing
May 2021

Alizarin and Purpurin from L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity.

ACS Chem Neurosci 2021 May 25. Epub 2021 May 25.

Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, P. R. China.

Alizarin (1,2-dihydroxyanthraquinone) and purpurin (1,2,4-trihydroxyanthraquinone), natural anthraquinone compounds from L., are reported to have diverse biological effects including antibacterial, antitumor, antioxidation, and so on, but the inhibition activity against amyloid aggregation has been rarely reported. In this study, we used insulin as a model protein to explore the anti-amyloid effects of the two compounds. The results showed that alizarin and purpurin inhibited the formation of insulin fibrils in a dose-dependent manner and reduced insulin-induced cytotoxicity. Meanwhile, purpurin had a more significant inhibitory effect on insulin amyloid fibrils compared with alizarin. In addition, computer simulations indicated that the two compounds interacted mainly with the hydrophobic residues of insulin chain B and interfered with the binding of phenylalanine residues. The research indicated that natural anthraquinone compounds had potential effects in preventing protein misfolding diseases and could be further used to design effective antiamyloidosis compounds.
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http://dx.doi.org/10.1021/acschemneuro.1c00177DOI Listing
May 2021

[Outcome of modified Kidner procedure with tendoscopy for the treatment of painful accessory navicular].

Zhongguo Gu Shang 2021 May;34(5):448-51

Department of Orthopaedics, General Hospital of PLA, Beijing 100853, China.

Objective: To evaluate clinical efficacy of modified kidner procedure with tendoscopy in treating painful accessory navicular.

Methods: From February 2014 to April 2019, 19 patients with painful accessory navicular were admitted, including 13 males and 6 females with a mean age of 26 years old (ranged from 14 to 58 years old), all of which were unilateral symptoms. The courses of disease ranged from 6 to 60 months. All patients received excision of accessory navicular and reconstruction of posterior tibial tendon insertion on navicular with anchor, and the tendoscopy were used to examin the posterior tibial tendon. American Orthopedic Foot and Ankle Society(AOFAS) midfoot score and visual analogue scale(VAS) were used to evaluate efficacy before operation and at the latest follow-up.

Results: All the patientswere followed up, and the duration ranged from 12 to 73 months, with an average of (35.0±20.9) months. VAS score was 0.20±0.41 at the latest follow-up, showing significant difference when compared with preoperative score of 6.33±1.95(=11.50, <0.01). AOFAS score was 95.53±5.79 at the latest follow-up, showing significant difference when compared with preoperative score of 60.27±21.51 (=5.71, <0.01).

Conclusion: The modified kidner procedure with tendoscopy is a good choice for the treatment of painful accessory navicular, which could obviously relieve foot pain, improve foot function, and has certain clinical efficacy.
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http://dx.doi.org/10.12200/j.issn.1003-0034.2021.05.010DOI Listing
May 2021

Self-Assembly of Peptide Hierarchical Helical Arrays with Sequence-Encoded Circularly Polarized Luminescence.

Nano Lett 2021 May 20. Epub 2021 May 20.

School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, P.R. China.

Self-assembled peptide materials with sequence-encoded properties have attracted great interest. Despite their intrinsic chirality, the generation of circularly polarized luminescence (CPL) based on the self-assembly of simple peptides has been rarely reported. Here, we report the self-assembly of peptides into hierarchical helical arrays (HHAs) with controlled supramolecular handedness. The HHAs can emit full-color CPL signals after the incorporation of various achiral fluorescent molecules, and the value is 40 times higher than that of the CPL signal from the solutions. By simply changing the amino acid sequence of the peptides, CPL signals with opposite handedness can be generated within the HHAs. The peptide HHAs can provide hydrophobic pockets to accommodate the fluorescent molecules with helical arrangement through strong aromatic stacking interactions, which are responsible for the CPL signals. This work provides a pathway to construct highly ordered chiral materials, which have broad applications in the chiroptical field.
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http://dx.doi.org/10.1021/acs.nanolett.1c00697DOI Listing
May 2021

Efficient separation and recovery of Re(VII) from Re/U bearing acidic solutions using aminotriazole modified cellulose microsphere adsorbents.

Environ Sci Pollut Res Int 2021 May 18. Epub 2021 May 18.

State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

In this work, aminotriazole-modified microcrystalline cellulose microsphere (3-ATAR) containing an abundant nitrogen content as promising adsorbent was prepared via a radiation grafting method for the selective recovery ReO in the presence of UO in acidic solution. A series of batch and column adsorption experiments including monocomponent and binary systems were designed for evaluating the adsorption and separation performance of Re(VII) onto 3-ATAR. The 3-ATAR exhibited a good adsorption capacity (max 146.4 mg·g) of Re(VII) and a rapid adsorption rate, with equilibrium time of 45 min. In binary solution, the high selectivity coefficients (β) indicated that 3-ATAR could separate and recover Re(VII) from U(VI) and other metal ions (Cu(II), Cr(III), Ni(II), Zn(II)). In particular, it was found that the adsorption of Re was almost unaffected in U/Re-bearing solutions no matter how much the U(VI) was changed. In the column experiment, when the concentration of U(VI) was 40 times higher than that of Re(VII), 3-ATAR manifested high Re(VII) selectivity over U(VI) from a synthetic uranium ore leachate. This work demonstrated that 3-ATAR could provide an efficient, selectively, sustainable, and industrially feasible way for Re(VII) to be recovered from uranium ore leachate and other prospective sources.Graphical abstract.
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http://dx.doi.org/10.1007/s11356-021-14356-wDOI Listing
May 2021

Modeling sulfide production in full flow concrete sewers based on the HRT variation of sewerage.

Water Sci Technol 2021 May;83(9):2063-2074

Low-Carbon Water Environment Technology Research Center, School of Environment & Natural Resources, Renmin University of China, Beijing 100872, China E-mail:

The corrosion and odor in concrete sewers are mainly related to the sulfide production, which is, under certain circumstances, directly proportional to the hydraulic retention time (HRT) of the sewer. To reduce the corrosion and control the odor in concrete sewers, it is necessary to model the production of sulfide in the concrete sewers with different HRTs. However, previous researches were mostly carried out in simulated Perspex-made sewers, and the obtained theoretical formulas based on the Monod equation were impractical because of the complexity. An actual concrete pipe with domestic sewage was employed in this study to obtain a simple but practical model, which can be applied to quantitively describe the sulfide production according to the HRT of the sewer and the chemical oxygen demand (COD) of the sewage. The empirical equation obtained was r = (0.045 × lnHRT + 0.071) × ([COD] - b), the coefficient is a logarithmic function of the HRT, and the sulfide production rate and COD have a power relationship. Based on the data of COD and HRT obtained in the realistic sewer, the production of sulfide in the sewer can be predicted for better maintaining sewers through sulfide control.
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http://dx.doi.org/10.2166/wst.2021.111DOI Listing
May 2021

The Z-scheme NH-UiO-66/PTCDA composite for enhanced photocatalytic Cr(VI) reduction under low-power LED visible light.

Chemosphere 2021 May 4;280:130734. Epub 2021 May 4.

College of Materials Science and Engineering, Beijing University of Technology, Beijing, 100124, China.

Series Z-scheme NH-UiO-66/PTCDA (NU100PX) composites constructed from NH-UiO-66 and PTCDA (3,4,9,10-perylenetetracarboxylic dianhydride) were obtained by simple ball-milling method. The photocatalytic Cr(VI) reduction activities of the NU100PX composites were conducted upon the irradiation of low power LED visible light. The results revealed that the introduction of a small amount of PTCDA on the surface of NH-UiO-66 could broaden the light absorption range and boost the separation of photo-induced charge carriers to promote the photocatalysis efficiency. The influence factors toward photocatalytic Cr(VI) cleanup performances of NU100P10 like pH, initial Cr(VI) concentrations, the impacts of small organic acids as hole capture agents along with various co-existing foreign matters were clarified. After 5 runs' adsorption-photoreduction towards Cr(VI), the NU100P10 still exhibited superior reduction activity and reusability. The Z-scheme mechanism of photocatalytic Cr(VI) removal over NU100P10 was put forward and certificated by electrochemical experiment, ESR (electron spin resonance) test, XPS determination, photo-deposition and DFT (density functional theory) calculation.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130734DOI Listing
May 2021

Two-Dimensional BiSrCaCuO Nanosheets for Ultrafast Photonics and Optoelectronics.

ACS Nano 2021 May 10;15(5):8919-8929. Epub 2021 May 10.

Department of Materials Science and Engineering, and ARC Centre of Excellence in Future Low-Energy Electronics Technologies, Monash University, Clayton, Victoria 3800, Australia.

Two-dimensional (2D) BiSrCaCuO (BSCCO) is a emerming class of 2D materials with high-temperature superconductivity for which their electronic transport properties have been intensively studied. However, the optical properties, especially nonlinear optical response and the photonic and optoelectronic applications of normal state 2D BiSrCaCuO (Bi-2212), have been largely unexplored. Here, the linear and nonlinear optical properties of mechanically exfoliated Bi-2212 thin flakes are systematically investigated. 2D Bi-2212 shows a profound plasmon absorption in near-infrared wavelength range with ultrafast carrier dynamics as well as tunable nonlinear absorption depending on the thickness. We demonstrated that 2D Bi-2212 can be applied not only as an effective mode-locker for ultrashort pulse generation but also as an active medium for infrared light detection due to its plasmon absorption. Our results may trigger follow up studies on the optical properties of 2D BSCCO and demonstrate potential opportunities for photonic and optoelectronic applications.
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http://dx.doi.org/10.1021/acsnano.1c01567DOI Listing
May 2021

Two degree-of-freedom robotic eye: design, modeling, and learning-based control in foveation and smooth pursuit.

Bioinspir Biomim 2021 May 5. Epub 2021 May 5.

Electrical and Computer Engineering, George Mason University, 4400, University Drive, Fairfax, Virginia, 22030-4444, UNITED STATES.

With increasing ocular motility disorders affecting human eye movement, the need to understand the biomechanics of the human eye rises constantly. A robotic eye system that physically mimics the human eye can serve as a useful tool for biomedical researchers to obtain an intuitive understanding of the functions and defects of the extraocular muscles and the eye. This paper presents the design, modeling, and control of a two degree-of-freedom (2-DOF) robotic eye, driven by artificial muscles, in particular, made of super-coiled polymers (SCPs). Considering the highly nonlinear dynamics of the robotic eye system, this paper applies deep deterministic policy gradient (DDPG), a machine learning algorithm to solve the control design problem in foveation and smooth pursuit of the robotic eye. To the best of our knowledge, this paper presents the first modeling effort to establish the dynamics of a robotic eye driven by SCP actuators, as well as the first control design effort for robotic eyes using a DDPG-based control strategy. A linear quadratic regulator (LQR)-type reward function is proposed to achieve a balance between system performances (convergence speed and tracking accuracy) and control efforts. Simulation results are presented to demonstrate the effectiveness of the proposed control strategy for the 2-DOF robotic eye.
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http://dx.doi.org/10.1088/1748-3190/abfe40DOI Listing
May 2021

Electrical and visible light dual-responsive ZnO nanocomposite with multiple wound healing capability.

Mater Sci Eng C Mater Biol Appl 2021 May 26;124:112066. Epub 2021 Mar 26.

College of Chemistry, Nanchang University, Nanchang, Jiangxi 330088, PR China; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, PR China. Electronic address:

The healing process of open wounds is a competition between cells and bacteria. Therefore, a strategy that can quickly remove bacteria and promote cell proliferation to accelerate wound healing is urgently needed. Inspired by photoelectric synergy tactics, we improved both the optical and electrical response of zinc oxide (ZnO) through the modification of polydopamine (PDA) and reduced graphene oxide (rGO), thus obtaining a ZnO composite named PDA-rGO-ZnO (PrZ). Combined with the photoelectric double stimulation, the sterilization target could be completed from multiple physical levels simultaneously. More importantly, the band gap of ZnO was considerably narrowed by PDA encapsulation. The encapsulated ZnO thus could be effectively excited by pure yellow light (YL) with a moderate long wavelength, which fundamentally improved its safety in exerting photocatalytic antibacterial properties. In addition, we found that electrical stimulation (ES) could not only help to clear bacteria, but also facilitate the formation of new blood vessels. Animal experiments further showed that PrZ efficaciously regulated the immune response around the wound surface, promoted cell proliferation and the formation of collagen fibers, thereby accelerating wound healing.
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http://dx.doi.org/10.1016/j.msec.2021.112066DOI Listing
May 2021

Clinical Outcomes of Hip Arthroscopy for Hip Labrum Calcification in Young and Middle-Aged Patients.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China.

Objective: To investigate the methods and outcomes of hip arthroscopy for hip labrum calcification, and to discuss the clinical, imaging, and intraoperative findings of hip labrum calcification.

Methods: This is a therapeutic case series study. From January 2015 to June 2018, 15 patients who met the inclusion and exclusion criteria were followed up for at least 2 years for an analysis on the outcomes of arthroscopy in the treatment of hip labrum calcification and the clinical, imaging, and intraoperative findings of the patients. There were eight males and seven females, with an average age of 38.9 ± 8.8 years (range, 23-50 years). The visual analog scale (VAS), the modified Harris hip score (mHSS), and the international hip outcome tool (iHOT-12) were used to evaluate the outcomes of surgery.

Results: A total of 15 patients were followed up for at least 2 years (28.1 ± 2.9 months). The average calcified volume was 118.0 mm (range, 19.4-609.2 mm ) and calcified volume was related to the preoperative hip function score. Thirteen patients had pain in the groin area (86.7%). Labrum calcifications were located (according to the clock distribution) as follows: 14 patients were anterior and superior (11:00-3:00); 12 cases of femoroacetabular impingement (FAI) were observed during operation, including five cases of pincer type, two cases of cam type, and five cases of mixed type. VAS pain score means were 7.73 ± 1.28 before surgery, decreasing to 2.0 ± 0.89 and 1.73 ± 0.79 at 1 and 2 years post-surgery, respectively. mHSS scores were 57.40 ± 6.23 before surgery and 82.10 ± 4.76 and 83.18 ± 4.07, 1 and 2 years post-surgery, respectively; iHOT-12 mean score pre-surgery was 37.67 ± 4.85, increasing to 67.64 ± 5.30 and 72.18 ± 4.49, 1 and 2 years post-surgery, respectively. Compared with preoperative values, postoperative VAS, mHSS, and iHOT-12 scores were significantly improved (P < 0.01); iHOT-12 scores also significantly decreased from 1 to 2 years postoperatively (P = 0.034). No patient had complications.

Conclusion: Hip arthroscopy is an effective method for the treatment of hip labrum calcification. The size of calcification influenced preoperative symptoms and function. Long-term irritation from FAI may be one important cause of labrum calcification.
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http://dx.doi.org/10.1111/os.12998DOI Listing
May 2021

Low-Dimensional Inorganic Tin Perovskite Solar Cells Prepared by Templated Growth.

Angew Chem Int Ed Engl 2021 May 3. Epub 2021 May 3.

School of Physical Science and Technology, Shanghaitech University, 393 Middle Huaxia Road, Shanghai, China.

The manipulation of the dimensionality and nanostructures based on the precise control of the crystal growth kinetics boosts the flourishing development of perovskite optoelectronic materials and devices. Herein, a low-dimensional inorganic tin halide perovskite, CsSnBrI (SCN) , with a mixed 2D and 3D structure is fabricated. A kinetic study indicates that Sn(SCN) and phenylethylamine hydroiodate can form a 2D perovskite structure that acts as a template for the growth of the 3D perovskite CsSnBrI (SCN) . The film shows an out-of-plane orientation and a large grain size, giving rise to reduced defect density, superior thermostability, and oxidation resistance. A solar cell based on this low-dimensional film reaches a power conversion efficiency of 5.01 %, which is the highest value for CsSnBr I perovskite solar cells. Furthermore, the device shows enhanced stability in ambient air.
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http://dx.doi.org/10.1002/anie.202104958DOI Listing
May 2021

CMOS-compatible integrated 4-f system for mode-transparent spatial manipulation.

Opt Lett 2021 May;46(9):2220-2223

To exploit spatial dimension, on-chip optical modes with various spatial profiles have been utilized in optical interconnects and spatial analog computing. An integrated Fourier optical system is able to perform spatial operations. However, the reported schemes based on a subwavelength structure pose difficulty in fabrication, and the fabrication-friendly structure has been investigated only with a fundamental mode. With the complementary metal-oxide-semiconductor process, we propose an integrated 4-f system with simple geometry and a moderate minimum feature size to manipulate the mode's spatial size and position in a mode-transparent way. A size magnification of 2.5 and center-to-center position offset of 7 µm are experimentally demonstrated. Reasonable insertion loss and low inter-mode crosstalk are measured over a 30 nm bandwidth. The work in this Letter paves the way for an on-chip Fourier optical system with convenient fabrication and broadband operation.
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http://dx.doi.org/10.1364/OL.417037DOI Listing
May 2021

Coaching via Telehealth: Caregiver-Mediated Interventions for Young Children on the Waitlist for an Autism Diagnosis Using Single-Case Design.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Special Education and Clinical Sciences, University of Oregon, Eugene, OR 97403, USA.

Years can elapse between parental suspicion of a developmental delay and a diagnostic assessment, ultimately delaying access to medically necessary, autism-specific intervention. Using a single-case, concurrent multiple baseline design, autism spectrum disorder symptomology (i.e., higher-order restrictive and repetitive behaviors and interests; higher-order RRBIs) was targeted in toddlers (21-35 months) waiting for a diagnostic appointment. Caregivers were coached via telehealth to mediate early intervention to decrease interfering, inflexible higher-order RRBIs during play using four evidence-based applied behavior analytic strategies: modeling, prompting, differential reinforcement of appropriate behaviors, and response interruption and redirection. Six mother-child dyads were recruited from pediatrician offices and early intervention service districts in the United States. All families were considered under-served, under-resourced, or living in rural locations. A visual analysis of the data combined with Tau-U revealed a strong basic effect between the intervention package and parent strategy use and child flexible and inflexible behavior. Findings were consistent across participants with one exception demonstrating a moderate effect for flexible behaviors yet a strong effect for inflexible behaviors. Standardized mean difference was beyond zero for all participants. Implications for science and practice include support for early intervention of higher-order RRBIs for young children with and at risk for ASD.
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http://dx.doi.org/10.3390/jcm10081654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070073PMC
April 2021

Photobiomodulation therapy for management of inferior alveolar nerve injury post-extraction of impacted lower third molars.

Lasers Dent Sci 2020 Mar 17;4(1):25-32. Epub 2019 Dec 17.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Purpose: Inferior alveolar nerve (IAN) injury is one of the most serious complications after extraction of impacted lower third molars. Photobiomodulation (PBM) therapy has been noted to reduce pain and inflammation while promoting tissue healing. This study examined the efficacy of PBM therapy tested in a case series of patients with postoperative IAN injury.

Material And Methods: 20 patients with post-extraction IAN injury were involved in this study and divided into two groups. In the study group, PBM therapy (808-nm laser, 16 mW, 3 J/cm) was used every other day for 2 weeks solely on post-extraction sockets in 10 patients diagnosed with IAN injury. In the control group, mecobalamine was prescribed to 10 patients with IAN injury. Objective and subjective recovery of IAN paresthesia was evaluated using clinical neurosensory testing and visual analog score.

Results: All patients showed improvement in both objective and subjective examination. Notably, the visual analog score was significantly improved after PBM treatment compared to the mecobalamine treatment ( < 0.05).

Conclusion: PBM therapy with 808-nm laser appears to be an effective approach to manage paresthesia post-IAN injury following impacted third molar surgery. Given the limited sample size in this study, large-scale, placebo-controlled, multi-center randomized controlled trials are needed for further validation of this innovative treatment.
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http://dx.doi.org/10.1007/s41547-019-00075-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075319PMC
March 2020

Effects of endplate healing morphology on intervertebral disc degeneration after pedicle screw fixation for thoracolumbar fractures.

Medicine (Baltimore) 2021 Apr;100(17):e25636

Orthopaedic Trauma Service Center, The Third Hospital of Hebei Medical University, Major Laboratory of Orthopaedic Biomechanics in Hebei Province.

Abstract: The cartilage endplate plays an important role in the stress distribution and nutrition metabolism of the intervertebral disc. The healing morphology of the endplate after spinal fracture and its effect on the intervertebral disc degeneration are still unclear.This was a retrospective study. Patients with traumatic single-level thoracolumbar fractures treated in our orthopedic trauma service center from June 2011 to May 2019 were included and the relevant data were collected from the medical records. Based on combined computed tomography and MRI images, the endplate injury status was determined (no endplate injury, unilateral and bilateral endplate injury). According to the location of the injury, endplate injury was further divided into endplate central injury and endplate peripheral injury. The degree of posttraumatic disc lesions and disc degeneration during follow-up were classified based on the Sander classification and the Pfirrmann classification, respectively. According to the T1 image of MRI at the final follow-up, the healing morphology of endplates was determined and classified. Univariate analyses and correlation analyses were performed to evaluate the within- and between-group differences.There were in total 51 patients included in this study. Cartilage endplate fracture was significantly closely related to the degree of degeneration of the intervertebral disc (P = .003). Injuries in different parts of the endplate have no significant effect on the intervertebral disc degeneration (P = .204). The healing morphology after endplate fracture significantly affected the degree of intervertebral disc degeneration (P = .001). The comparisons of groups showed that the effects of irregular healing and traumatic Schmorl nodes on disc degeneration were not statistically significant, but were significantly significant with increased curvature.These results suggest that the irregular healing and the traumatic Schmorl nodes are closely related to intervertebral disc degeneration. The presence and severity of the endplate injury can provide valuable information for individualized clinical decision-making processes.
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http://dx.doi.org/10.1097/MD.0000000000025636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084067PMC
April 2021

Enhanced enzymatic hydrolysis of cellulose by endoglucanase via expansin pretreatment and the addition of zinc ions.

Bioresour Technol 2021 Aug 7;333:125139. Epub 2021 Apr 7.

State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China; School of Marine Science and Technology, Tianjin University, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China. Electronic address:

One of the major limitations of lignocellulose conversion is the relatively low efficiency of cellulases. Expansins can act as an accessory protein to loosen the rigid cellulose structure and promote cellulose hydrolysis. However, the synergistic action of expansin is not well understood. In this study, we employed quartz crystal microbalance with dissipation to real-time monitor the adsorption of Bacillus subtilis expansin (BsEXLX1) and endoglucanase I (Cel7B) and the hydrolysis of cellulose. The effects of pH, temperature, and zinc ions on the initial adsorption rate and adsorption capacity of BsEXLX1 were examined. When 36.5 mM of zinc ions was added, the irreversible adsorption ratio of BsEXLX1 further increased to 4.63 times the value in the absence of zinc ions, whereas the initial adsorption rate and the hydrolysis rate constants of Cel7B could reach 2.16 times and 2.05 times the values in the absence of zinc ions, respectively.
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http://dx.doi.org/10.1016/j.biortech.2021.125139DOI Listing
August 2021

Protective effects of sunlight exposure against PRK-induced myopia in infant rhesus monkeys.

Ophthalmic Physiol Opt 2021 Apr 20. Epub 2021 Apr 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: Extensive clinical evidence suggests that time spent outdoors might reduce the risk of myopia. This study aimed to determine whether increasing sunlight exposure has a protective effect on hyperopic-defocus induced myopia in a non-human primate.

Methods: Twelve 2-month-old rhesus monkeys were treated monocularly with photorefractive keratectomy (PRK) (4.0 D) and divided randomly into two groups: artificial light (AL; n = 6) and natural light (NL; n = 6). Monkeys in the AL group were reared under artificial (indoor) lighting (08:00-20:00 h). Monkeys in the NL group were exposed to natural (outdoor) lighting for 4 h (09:00-11:00 and 15:00-17:00 h). Ocular refraction, corneal power and axial dimensions were measured before sunlight exposure and every 10 days after PRK. At day 180, retinal histology and apoptosis activity were evaluated by hematoxylin and eosin (H&E) staining and terminal deoxynucleotidyl transferase biotin (dUTP) nick end labelling (TUNEL) assay.

Results: Mean (±SD) PRK induced anisometropia was +3.11 (0.33) D. At the end of the experiment, both eyes of the NL monkeys exhibited significantly more hyperopia and shorter vitreous chamber depths (VCD), compared with AL monkeys (p < 0.05). The NL group exhibited a significantly slower rate of compensation to the induced anisometropia than the AL group (p < 0.05). The retinas of both groups exhibited normal histology and levels of apoptosis.

Conclusions: Moderate sunlight exposure exerts protective effects against the myopic shift resulting from PRK-induced defocus in monkeys. These results are consistent with current clinical findings that increased outdoor exposure protects against myopia development. Sunlight exposure should serve as an independent positive factor in human myopia control.
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http://dx.doi.org/10.1111/opo.12826DOI Listing
April 2021

Highly Efficient Electro-reforming of 5-Hydroxymethylfurfural on Vertically Oriented Nickel Nanosheet/Carbon Hybrid Catalysts: Structure-Function Relationships.

Angew Chem Int Ed Engl 2021 Apr 20. Epub 2021 Apr 20.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, Liaoning, 110016, China.

Ni-promoted electrocatalytic biomass reforming has shown promising prospect in enabling high value-added product synthesis. Here, we developed a novel hybrid catalyst with Ni nanosheet forests anchored on carbon paper. The hybrid catalyst exhibits high efficiency in electrooxidation of HMF to FDCA coupling with H production in high purity. The Ni nanosheets have small crystal grain sizes with abundant edges, which is able to deliver an efficient HMF oxidation to FDCA (selectivity >99 %) at low potential of 1.36 V with high stability. The post-reaction structure analysis reveals the Ni nanosheets would transfer electrons to carbon and readily turn into NiO and Ni(OH) during the reaction. DFT results suggest high valence Ni species would facilitate the chemical adsorption (activation) of HMF revealing the reaction pathway. This work emphasizes the importance of the precise control of Ni activity via atomic structure engineering.
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http://dx.doi.org/10.1002/anie.202102359DOI Listing
April 2021

Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial.

Psychiatry Res Neuroimaging 2021 06 7;312:111286. Epub 2021 Apr 7.

Department of Psychiatry, NYU Langone Health, 1 Park Avenue, New York, NY 10016, United States of America; Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States of America. Electronic address:

Hippocampal volume loss is prominent in first episode schizophrenia (FES) and has been associated with poor clinical outcomes and with BDNF genotype; antidepressants are believed to reverse hippocampal volume loss via release of BDNF. In a 12-month, placebo-controlled add-on trial of the antidepressant, citalopram, during the maintenance phase of FES, negative symptoms were improved with citalopram. We now report results of structural brain imaging at baseline and 6 months in 63 FES patients (34 in citalopram group) from the trial to assess whether protection against hippocampal volume loss contributed to improved negative symptoms with citalopram. Hippocampal volumetric integrity (HVI) did not change significantly in the citalopram or placebo group and did not differ between treatment groups, whereas citalopram was associated with greater volume loss of the right CA1 subfield. Change in cortical thickness was associated with SANS change in 4 regions (left rostral anterior cingulate, right frontal pole, right cuneus, and right transverse temporal) but none differed between treatment groups. Our findings suggest that minimal hippocampal volume loss occurs after stabilization on antipsychotic treatment and that citalopram's potential benefit for negative symptoms is unlikely to result from protection against hippocampal volume loss or cortical thinning.
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http://dx.doi.org/10.1016/j.pscychresns.2021.111286DOI Listing
June 2021

Deep Learning-Based 2-D Frequency Estimation of Multiple Sinusoidals.

IEEE Trans Neural Netw Learn Syst 2021 Apr 14;PP. Epub 2021 Apr 14.

Frequency estimation of 2-D multicomponent sinusoidal signals is a fundamental issue in the statistical signal processing community that arises in various disciplines. In this article, we extend the DeepFreq model by modifying its network architecture and apply it to 2-D signals. We name the proposed framework 2-D ResFreq. Compared with the original DeepFreq framework, the 2-D convolutional implementation of the matched filtering module facilitates the transformation from time-domain signals to frequency-domain signals and reduces the number of network parameters. The additional upsampling layer and stacked residual blocks are designed to perform superresolution. Moreover, we introduce frequency amplitude information into the optimization function to improve the amplitude accuracy. After training, the signals in the test set are forward-mapped to 2-D accurate and high-resolution frequency representations. Frequency and amplitude estimation are achieved by measuring the locations and strengths of the spectral peaks. We conduct numerical experiments to demonstrate the superior performance of the proposed architecture in terms of its superresolution capability and estimation accuracy.
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http://dx.doi.org/10.1109/TNNLS.2021.3070707DOI Listing
April 2021