Publications by authors named "Qi Feng"

671 Publications

A method to remove the influence of fixative concentration on postmortem T maps using a kinetic tensor model.

Hum Brain Mapp 2021 Sep 20. Epub 2021 Sep 20.

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.

Formalin fixation has been shown to substantially reduce T estimates, primarily driven by the presence of fixative in tissue. Prior to scanning, post-mortem samples are often placed into a fluid that has more favourable imaging properties. This study investigates whether there is evidence for a change in T in regions close to the tissue surface due to fixative outflux into this surrounding fluid. Furthermore, we investigate whether a simulated spatial map of fixative concentration can be used as a confound regressor to reduce T inhomogeneity. To achieve this, T maps and diffusion tensor estimates were obtained in 14 whole, formalin-fixed post-mortem brains placed in Fluorinert approximately 48 hr prior to scanning. Seven brains were fixed with 10% formalin and seven brains were fixed with 10% neutral buffered formalin (NBF). Fixative outflux was modelled using a proposed kinetic tensor (KT) model, which incorporates voxelwise diffusion tensor estimates to account for diffusion anisotropy and tissue-specific diffusion coefficients. Brains fixed with 10% NBF revealed a spatial T pattern consistent with modelled fixative outflux. Confound regression of fixative concentration reduced T inhomogeneity across both white and grey matter, with the greatest reduction attributed to the KT model versus simpler models of fixative outflux. No such effect was observed in brains fixed with 10% formalin. Correlations between the transverse relaxation rate R and ferritin/myelin proteolipid protein (PLP) histology lead to an increased similarity for the relationship between R and PLP for the two fixative types after KT correction.
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http://dx.doi.org/10.1002/hbm.25661DOI Listing
September 2021

Visual Hg(II) sensing in aqueous solution via a new 2,5-Bis(4-pyridyl)thiazolo[5,4-d]thiazole-based fluorescence coordination polymer.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 7;265:120367. Epub 2021 Sep 7.

National Demonstration Center for Experimental Chemistry Education, Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China. Electronic address:

A new fluorescence coordination polymer [Zn(PyTTz)(5-OH-IPA)] (1) (PyTTz = 2,5-bis(4-pyridyl)thiazolo[5,4-d]thiazole, 5-OH-IPA = 5-hydroxyisophthalic acid dianion) was synthesized, which exhibited the characteristics of fluorescence quenching and bathochromic shift toward Hg(II) in aqueous solution at pH 7.00. Mechanism study showed that the interactions between Hg(II) ions and PyTTz ligands in 1 were responsible for the fluorescence emission change. Thanks to the specific interactions between 1 and Hg(II), excellent selectivity was achieved both in aqueous solution and in solid test paper. The detection limit of 1 for Hg(II) sensing was 125.76 nmol L and a linear rang was 1.00-10.00 μmol L. More importantly, satisfactory recovery and accuracy of 1 for Hg(II) sensing were also obtained in buffer-free real water samples.
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http://dx.doi.org/10.1016/j.saa.2021.120367DOI Listing
September 2021

Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice.

Hepatology 2021 Sep 12. Epub 2021 Sep 12.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.

Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in women, and an even higher prevalence in people with type 2 diabetes mellitus. Optimal pharmacologic therapeutic approaches for NAFLD are an urgent necessity. In this study, we showed that compared to healthy controls, hepatic ACSL4 levels in NAFLD patients were found to be elevated. Suppression of ACSL4 expression promoted mitochondrial respiration, thereby enhancing the capacity of hepatocytes to mediate β-oxidation of fatty acids and to minimize lipid accumulation by up-regulating PGC1α. Moreover, we found that abemaciclib is a potent and selective ACSL4 inhibitor, low-dose of abemaciclib significantly ameliorated most of the NAFLD symptoms in multiple NAFLD mice models. Therefore, inhibition of ACSL4 is a potential alternative therapeutic approach for NAFLD.
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http://dx.doi.org/10.1002/hep.32148DOI Listing
September 2021

Corrigendum to "Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1" [Biochem. Pharmacol. 178 (2020), 114092].

Biochem Pharmacol 2021 Sep 9;193:114757. Epub 2021 Sep 9.

Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong 510632, China; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2021.114757DOI Listing
September 2021

Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary.

ACS Biomater Sci Eng 2021 Sep 10. Epub 2021 Sep 10.

Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China.

Simulating the structure and function of blood capillaries is very important for an in-depth insight into their role in the human body and treatment of capillary-related diseases. Due to the similar composition and structure, hollow hydrogel microfibers are well-recognized as potential biomimetic blood capillaries. In this paper, we report a novel, facile, and reproducible method to fabricate coaxial microfluidic chips via 3D printing-assisted soft lithography and then hollow hydrogel microfibers using the as-prepared coaxial microfluidic chips. Instead of traditional photoresist-based lithography, 3D printing of gelatin hydrogel under various extrusion pressures is used to construct sacrificial templates of coaxial microfluidic chips. Various solid and hollow hydrogel microfibers with complicated and hierarchical structures can be obtained via multitype coaxial microfluidic chips or a combination of coaxial microfluidic fabrication and post-treatment. The as-formed hollow hydrogel microfibers are evaluated in detail as biomimetic blood capillaries, including physicochemical and cytological properties. Our results prove that the hollow hydrogel microfibers exhibit excellent mass transport capacity, hemocompatibility, semipermeability, and mechanical strength, and their barrier function can be further enhanced in the presence of endothelial cells. Overall, our 3D printing-assisted fabrication strategy provides a new technique to construct microfluidic chips with complicated 3D microchannels, and the resulting hollow hydrogel microfibers are promising candidates for blood capillaries.
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http://dx.doi.org/10.1021/acsbiomaterials.1c00980DOI Listing
September 2021

Correction to: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta‑analysis.

Cardiovasc Diabetol 2021 Sep 4;20(1):177. Epub 2021 Sep 4.

Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Room 1929B/K1931, Block K, Hong Kong, China.

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http://dx.doi.org/10.1186/s12933-021-01371-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418742PMC
September 2021

Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway.

J Exp Clin Cancer Res 2021 Sep 4;40(1):280. Epub 2021 Sep 4.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, China.

Background: Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate and drug resistance.

Methods: Suppression of TRCs may thus be an effective therapeutic strategy for treating this fatal disease. We evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of HCC TRCs, and assessed its preclinical efficacy in models of HCC patient-derived xenografts (PDXs).

Results: Sulfarotene selectively inhibited the growth of HCC TRCs in vitro and significantly deterred TRC-mediated tumor formation and lung metastasis in vivo without apparent toxicity, with an IC superior to that of acyclic retinoid and sorafenib, to which the recurrent HCC exhibits significant resistance at advanced stage. Sulfarotene promoted the expression and activation of RARα, which down-regulated SOS2, a key signal mediator associated with RAS activation and signal transduction involved in multiple downstream pathways. Moreover, sulfarotene selectively inhibited tumorigenesis of HCC PDXs with high expression for SOS2.

Conclusions: Our study identified sulfarotene as a selective inhibitor for the TRCs of HCC, which targets a novel RARα-SOS2-RAS signal nexus, shedding light on a new, promising strategy of target therapy for advanced liver cancer.
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http://dx.doi.org/10.1186/s13046-021-02085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418008PMC
September 2021

Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.

BMC Anesthesiol 2021 09 1;21(1):212. Epub 2021 Sep 1.

Department of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107, Wenhua West Road, Jinan, 250012, Shandong, China.

Background: The mechanism of volatile anesthetics on vascular smooth muscle (VSM) contraction in the setting of diabetes mellitus (DM) remains unclear. The current study was designed to determine the effects of sevoflurane (SEVO) and isoflurane (ISO) on phosphoinositide 3-kinase (PI3K) and Rho kinase (ROCK) mediated KCl-induced vasoconstriction in aged type 2 diabetic rats.

Methods: KCl-induced (60 mM) contractions were examined in endothelium-denuded aortic rings from aged T2DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats (65-70 weeks old), control age-matched nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and young Wistar rats (6-8 weeks old). The effects of SEVO or ISO (1-3 minimum alveolar concentration, MAC) on KCl-induced vasoconstriction, as well as those of LY294002 (PI3K inhibitor) and Y27632 (ROCK inhibitor) were measured in aortic rings from the three groups using an isometric force transducer.

Results: KCl induced rapid and continuous contraction of aortic smooth muscle in the three groups, and the contraction was more obvious in OLETF rats. SEVO and ISO inhibited KCl-induced vasoconstriction in a concentration-dependent manner and were suppressed by LY294002 (10 µM) and Y27632 (1 µM). SEVO had a stronger inhibitory effect on the aortas of young Wistar rats than ISO, especially at 2 MAC and 3 MAC (P < 0.05). In aged rats, the inhibitory effect of ISO was stronger than that of SEVO, especially OLETF rats. There was no significant difference in the effects of different concentrations of ISO on arterial contraction among the three groups (P > 0.05). The effects of 1 MAC SEVO on Wistar rats and 3 MAC SEVO on OLETF rats, however, were noticeably and significantly different (P < 0.05). Compared with the control condition, LY294002 and Y27632 had the most noticeable effect on the KCl-induced contraction of aortic rings in OLETF rats (P < 0.01).

Conclusion: SEVO (3 MAC), ISO (1, 2, 3 MAC), LY294002 and Y27632 have more significant inhibitory effect on the contraction of vascular smooth muscle in aged T2MD rats. The mechanism of SEVO and ISO in vascular tension in T2DM is partly due to changes in PI3K and/or Rho kinase activity.
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http://dx.doi.org/10.1186/s12871-021-01425-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408970PMC
September 2021

Awake fiberoptic intubation and use of bronchial blockers in ankylosing spondylitis patients.

World J Clin Cases 2021 Aug;9(23):6705-6716

Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China.

Background: Patients with ankylosing spondylitis (AS) combined with severe cervical fusion deformity have difficult airways. Awake fiberoptic intubation is the standard treatment for such patients. Alleviating anxiety and discomfort during intubation while maintaining airway patency and adequate ventilation is a major challenge for anesthesiologists. Bronchial blockers (BBs) have significant advantages over double-lumen tubes in these patients requiring one-lung ventilation.

Aim: To evaluate effective drugs and their optimal dosage for awake fiberoptic nasotracheal intubation in patients with AS and to assess the pulmonary isolation effect of one-lung ventilation with a BB.

Methods: We studied 12 AS patients (11 men and one woman) with lung or esophageal cancer who underwent thoracotomy with a BB. Preoperative airway evaluation found that all patients had a difficult airway. All patients received an intramuscular injection of penehyclidine hydrochloride (0.01 mg/kg) before anesthesia. In the operating room, dexmedetomidine(0.5 μg/kg) was infused intravenously for 10 min, with 2% lidocaine for airway surface anesthesia, and a 3% ephedrine cotton swab was used to contract the nasal mucosa vessels. Before tracheal intubation, fentanyl (1 μg/kg) and midazolam (0.02 mg/kg) were administered intravenously. Awake fiberoptic nasotracheal intubation was performed in the semi-reclining position. Intravenous anesthesia was administered immediately after successful intubation, and a BB was inserted laterally. The pre-intubation preparation time, intubation time, facial grimace score, airway responsiveness score during the fiberoptic introduction, time of end tracheal catheter entry into the nostril, and lung collapse and surgical field score were measured. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded while entering the operation room (T1), before intubation (T2), immediately after intubation (T3), 2 min after intubation (T4), and 10 min after intubation (T5). After surgery, all patients were followed for adverse reactions such as epistaxis, sore throat, hoarseness, and dysphagia

Results: All patients had a history of AS (20.4 ± 9.6 years). They had a Willson's score of 5 or above, grade III or IV Mallampati tests, an inter-incisor distance of 2.9 ± 0.3 cm, and a thyromental (T-M) distance of 4.8 ± 0.7 cm. The average pre-intubation preparation time was 20.4 ± 3.4 min, intubation time was 2.6 ± 0.4 min, facial grimace score was 1.7 ± 0.7, airway responsiveness score was 1.1 ± 0.7, and pulmonary collapse and surgical exposure score was 1.2 ± 0.4. The SBP, DBP, and HR at T5 were significantly lower than those at T1-T4 ( < 0.05). While the values at T1 were not significantly different from those at T2-T4 ( > 0.05), they were significantly different from those at T5 ( < 0.05). Seven patients had minor epistaxis during endotracheal intubation, two were followed 24 h after surgery with a mild sore throat, and two had hoarseness without dysphagia.

Conclusion: Patients with AS combined with severe cervical and thoracic kyphosis should be intubated using fiberoptic bronchoscopy under conscious sedation and topical anesthesia. Proper doses of penehyclidine hydrochloride, dexmedetomidine, fentanyl, and midazolam, combined with 2% lidocaine, administered prior to intubation, can provide satisfactory conditions for tracheal intubation while maintaining the comfort and safety of patients. BBs are safe and effective for one-lung ventilation in such patients during thoracotomy.
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http://dx.doi.org/10.12998/wjcc.v9.i23.6705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362533PMC
August 2021

Analysis of wet deposition characteristics in the city of Guilin, China.

Environ Monit Assess 2021 Aug 24;193(9):597. Epub 2021 Aug 24.

College of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.

In this study, the rainfall, pH, conductivity, and ionic component data for Guilin from 2015 to 2017 were analyzed. Specifically, the relationship between the pH value of the rainfall, the change of each ion in the rainfall, and the primary ion sources was examined. The main results obtained were as follows. During the 3-year study period, the average annual pH value of Guilin was 5.45 and exhibited a downward trend. The seasonal variation of rainfall acidity was pronounced, with high pH values and low frequencies of acid rain in summer, and low pH values and high frequencies of acid rain in winter. From 2015 to 2017, the relative order of the average concentrations of the ionic components in the rainfall was SO  > NO  > Ca  > Cl  > NH  > Na  > K  > Mg  > F, the annual average concentration of each ionic component displayed a downward trend, and seasonal changes were obvious. Only NH showed an upward trend in rainfall. The (SO)/(NO) ratio was basically < 3 and manifested a downward trend; (Ca)/(NH) rose sharply in August and September each year. Using correlation analysis and enrichment factor analysis, it was concluded that the rainfall in Guilin is mainly affected by SO, NO, and NH, with the geological conditions in the karst area also contributing a certain amount to the rainfall acidity. Calculating the enrichment factor revealed that most of the Ca came from a crustal source; half the Mg came from the ocean and half came from the crust; and most of K and Cl originated from the ocean. Human activities contributed most of the SO and NO in the rainfall.
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http://dx.doi.org/10.1007/s10661-021-09396-1DOI Listing
August 2021

Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform trajectory and strategy of hybrid rice breeding.

Mol Plant 2021 Aug 11. Epub 2021 Aug 11.

National Center for Gene Research, State Key Laboratory of Plant Molecular Genetics, Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200233, China. Electronic address:

The male sterility (MS) line is a prerequisite for self-pollinating rice to efficiently produce hybrid seeds. MS line breeding is pivotal for hybrid rice improvement. Understanding the historical breeding trajectory will be helpful to improve hybrid rice breeding strategy. Maternally inherited cytoplasm is an appropriate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids. In this study, we analyzed the cytoplasmic genomes of 1,495 elite hybrid rice varieties, and identified 5 major types of cytoplasms, which were corresponding to different hybrid production systems. As the cytoplasm donor for hybrid, 461 MS lines were also divided into 5 major types based on the cytoplasmic and nuclear genomic architecture. And the specific core accessions cooperated with fertility-associated genes drove the sequence divergence of MS lines. Dozens to hundreds of convergent and divergent selective sweeps among different types of MS lines were identified, which spanned several agronomic trait-associated genes. We further summarized the cross pattern between different types of MS lines and corresponding restorers, respectively. This study systematically analyzed the cytoplasmic genome of rice hybrid for the first time, revealed its association with nuclear genome of MS lines, further conducted classification based on variations from both genomes, and provided new insights into hybrid rice breeding.
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http://dx.doi.org/10.1016/j.molp.2021.08.007DOI Listing
August 2021

Effects of cascade reservoir systems on the longitudinal distribution of sediment characteristics: a case study of the Heihe River Basin.

Environ Sci Pollut Res Int 2021 Aug 11. Epub 2021 Aug 11.

College of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou, ,730050, China.

Spatial variations in grain size parameters can reflect river sediment transport patterns and depositional dynamics. Therefore, 22 surficial sediment samples taken from the Heihe River and its cascade reservoirs were analyzed to better understand the impact of cascade reservoir construction on sediment transport patterns in inland rivers in China. The results showed that the longitudinal distribution of sediment grain size in the Heihe River was significantly affected by the influence of the cascade reservoirs. The retention rate in the cascade reservoir of the Heihe River reached 79% (193.53 Mt/year), which caused most of the fine sand to accumulate in the reservoir, and the sediment fining degree reached approximately 50%. However, the water discharged from the dam caused serious erosion of the riverbed and coarsening of the sediment, and the coarsening degree was approximately 500%. The backwater zone of the reservoir was influenced by both backwater and released water, and the coarsening degree of sediment was approximately 101%. Sedimentary environmental analysis revealed that the characteristics of the sediment grain size in an upstream tributary of the Heihe River were more influenced by source material than by hydrodynamic conditions, while the grain size characteristics of the mainstream sediments were controlled mainly by hydrodynamic conditions. The characteristics of sediment transport in different reaches of the Heihe River were studied, and the results may provide references for the operation of cascade reservoirs and the sediment control of reservoirs.
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http://dx.doi.org/10.1007/s11356-021-15760-yDOI Listing
August 2021

Elevated Serum Levels of Soluble ST2 Are Associated With Plaque Vulnerability in Patients With Non-ST-Elevation Acute Coronary Syndrome.

Front Cardiovasc Med 2021 22;8:688522. Epub 2021 Jul 22.

Department of Cardiology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

Recent studies have suggested that soluble suppression of tumorigenicity-2 (sST2), an inflammation-related protein receptor, is associated with atherosclerotic diseases. This study aimed to investigate the potential predictive value of sST2 on plaque vulnerability by assessing whether elevated serum levels of sST2 are associated with vulnerable plaque features in patients with non-ST-elevation acute coronary syndrome (ACS). A total of 120 patients with non-ST-elevation ACS (167 lesions) were prospectively enrolled and evaluated by standard coronary computed tomography angiography (CCTA) and coronary angiography in this study. Serum sST2 levels were measured by ELISA (Presage ST2 Assay Kit, Critical Diagnostics), and semiautomated software (QAngioCT, Medis) was used to quantify coronary plaques. The included patients were divided into 4 groups by serum sST2 level quartiles. Volumetric analysis of the whole lesion revealed that patients with higher sST2 levels had a larger absolute necrotic core (NC) volume (Quartile 4 vs. Quartile 1, 86.16 ± 59.71 vs. 45.10 ± 45.80 mm, = 0.001; Quartile 4 vs. Quartile 2, 86.16 ± 59.71 vs. 50.22 ± 42.56 mm, = 0.002) and a higher NC percentage (Quartile 4 vs. Quartile 1, 35.16 ± 9.82 vs. 23.21 ± 16.18%, < 0.001; Quartile 4 vs. Quartile 2, 35.16 ± 9.82% vs. 22.50 ± 14.03%, < 0.001; Quartile 4 vs. Quartile 3, 35.16 ± 9.82% vs. 25.04 ± 14.48%, < 0.001). Correlation analysis revealed that serum sST2 levels were positively correlated with the NC ( = 0.323, < 0.001) but negatively correlated with dense calcium ( = -0.208, = 0.007). Furthermore, among those with plaque calcification, patients with spotty calcification exhibited higher serum sST2 levels than those with large calcification (26.06 ± 16.54 vs. 17.55 ± 7.65 ng/mL, = 0.002). No significant differences in plaque components at the level of the minimal lumen area (MLA) were found among the groups. Serum sST2 levels were correlated with different coronary plaque components in patients with non-ST-elevation ACS. A higher serum level of sST2 was correlated with plaque vulnerability. www.ClinicalTrials.gov, identifier: NCT04797819.
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http://dx.doi.org/10.3389/fcvm.2021.688522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341076PMC
July 2021

Novel factor VII gene mutations in six families with hereditary coagulation factor VII deficiency.

J Clin Lab Anal 2021 Sep 2;35(9):e23905. Epub 2021 Aug 2.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Introduction: Hereditary human coagulation factor VII (FVII) deficiency is an inherited autosomal recessive hemorrhagic disease involving mutations in the F7 gene. The sites and types of F7 mutations may influence the coagulation activities of plasma FVII (FVII: C) and severity of hemorrhage symptoms. However, the specific mutations that impact FVII activity are not completely known.

Methods: We tested the coagulation functions and plasma activities of FVII in seven patients recruited from six families with hereditary FVII deficiency and sequenced the F7 gene of the patients and their families. Then, we analyzed the genetic information from the six families and predicted the structures of the mutated proteins.

Results: In this study, we detected 11 F7 mutations, including four novel mutations, in which the mutations p.Phe84Ser and p.Gly156Cys encoded the Gla and EGF domains of FVII, respectively, while the mutation p.Ser339Leu encoded the recognition site of the enzymatic protein and maintained the conformation of the catalytic domain structure. Meanwhile, the mutation in the 5' untranslated region (UTR) was closely associated with the mRNA regulatory sequence.

Conclusion: We have identified novel genetic mutations and performed pedigree analysis that shed light on the pathogenesis of hereditary human coagulation FVII deficiency and may contribute to the development of treatments for this disease.
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http://dx.doi.org/10.1002/jcla.23905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418470PMC
September 2021

Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases.

Oxid Med Cell Longev 2021 11;2021:4578809. Epub 2021 Jul 11.

Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often leads to abnormal function of cardiomyocytes or vascular endothelial cells and cardiovascular disease (CVD). Mitochondria-associated membrane (MAM) is involved in several important cellular functions. Increasing evidence shows that MAM is involved in the pathogenesis of CVD. MAM mediates multiple cellular processes, including calcium homeostasis regulation, lipid metabolism, unfolded protein response, ROS, mitochondrial dynamics, autophagy, apoptosis, and inflammation, which are key risk factors for CVD. In this review, we discuss the structure of MAM and MAM-associated proteins, their role in CVD progression, and the potential use of MAM as the therapeutic targets for CVD treatment.
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http://dx.doi.org/10.1155/2021/4578809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289621PMC
July 2021

Investigation into the impact of aged microplastics on oil behavior in shoreline environments.

J Hazard Mater 2021 Jul 21;421:126711. Epub 2021 Jul 21.

Department of Building, Civil and Environmental Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.

Understanding the interactions between oil and other particles in shoreline can help determine the environmental risk and cleanup strategy after oil spill. Nevertheless, far less has been known regarding the impact of aged MPs on oil behavior in the shoreline environment. In this study, the aging course of polyethylene (PE) in shaking seawater and ultraviolet (UV) radiation conditions was investigated. The seawater aging mainly affected the physical properties of MPs, increasing its surface pores and hydrophilicity. UV aging significantly affected both the physical and chemical properties of MPs, which increased its hydrophilicity and crystallinity, decreased its mean particle size and introduced oxygen-containing functional groups onto MPs. The two-dimensional correlation spectroscopy (2D COS) analysis confirmed the evolution of oxygen-containing functional groups from C-O to CO. The effects of aged MPs on oil behavior in water-sand system were further explored. The oil remaining percentages were non-linearly changed with the increasing aging degree of MPs. The particle size of the aqueous phase after washing was inversely related to the oil remaining percentage. Further FTIR analysis revealed that C-O and C-H functional groups played an important role in the process of oil adsorbed on MPs.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126711DOI Listing
July 2021

Hormone Receptor Status May Impact the Survival Benefit Between Medullary Breast Carcinoma and Atypical Medullary Carcinoma of the Breast: A Population-Based Study.

Front Oncol 2021 6;11:677207. Epub 2021 Jul 6.

Department of Oncology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.

Background: A rare subtype of breast cancer, atypical medullary carcinoma of the breast (AMCB), shows a highly adverse prognosis compared to medullary carcinoma of the breast (MBC). The current study aimed to establish a correlated nomogram for the identification of the prognostic factors of AMCB and MBC.

Methods: Kaplan-Meier and Cox regression analyses were applied to data acquired from the Surveillance, Epidemiology and End Results (SEER) database for 2004 to 2013 to analyse tumour characteristics and overall survival. Propensity score matching (PSM) analysis was performed to determine the overall survival (OS) among those with AMCB and MBC. A predictive nomogram was created, and the concordance index (C-index) was used to predict accuracy and discriminative ability.

Results: A total of 2,001 patients from the SEER database were diagnosed with MBC between 2004 and 2013, including 147 patients diagnosed with AMCB. The number of diagnoses gradually increased in both groups. Cox analysis of multivariate and Kaplan-Meier analysis showed that older age (HR = 3.005, 95% CI 1.906-4.739) and later stage were significantly associated with poor prognosis, while cancer-directed surgery was an independent protective factor (HR = 0.252, 95% CI 0.086-0.740). In the HR-negative stratification analysis, older age (HR = 2.476, 95% CI 1.398-4.385), later stage and histological type (HR=0.381, 95% CI 0.198-0.734) were found to be independent prognostic factors for low standard survival. The log-rank analysis demonstrated significantly worse prognostic factors for patients with AMCB than for those with MBC ( = 0.004). A nomogram (C-index for survival = 0.75; 95% CI 0.69-0.81) was established from four independent prognostic factors after complete identification.

Conclusions: MBC is rare, and cancer-directed surgery, older age, and later stage are independently linked with prognosis. In the HR negative population, AMCB patients show a worse survival gain than those with MBC.
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http://dx.doi.org/10.3389/fonc.2021.677207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290126PMC
July 2021

Assessing the coastal sensitivity to oil spills from the perspective of ecosystem services: A case study for Canada's pacific coast.

J Environ Manage 2021 Oct 14;296:113240. Epub 2021 Jul 14.

Department of Building, Civil and Environmental Engineering, Concordia University, Montreal, QC, H3G 1M8, Canada.

Coastal environment is one of the most important ecological and socioeconomic areas. However, increasing energy demand and economic development lead to a continuous gas and oil exploration, production, and traffics, which notably raise the risk of oil spill accidents in coastal areas. Sensitivity assessment aiming to determine the coastal features that would be severely impaired by spill incidents is a crucial part of the response planning. In this study, an innovative framework for coastal sensitivity mapping that incorporated ecosystem service (ES) valuation and multidimensional assessment was proposed. Sensitivity was computed by valuing physical, biological, and social-economical indicators from ES perspective and separating each indicator into specific coastal domains. For different ES typologies, provisioning services contributed most to the overall ES value followed by culture services, supporting services, and regulating services. For ES value in different coastal domains, the highest value was recorded in the water column followed by water surface, shoreline, and seabed. However, the shoreline ranked highest regarding the ES value per ha. Sensitivity assessment revealed that sensitive areas differed in different domains, both in distribution and extent. Compared with the scoring method, the ES valuation method showed more coincidence with Ecologically and Biologically Significant Areas (EBSA), representing a more precise and practical approach for sensitivity assessment. A three-dimensional (3D) oil spill model was also applied to generate maps of oil contamination probability in shoreline, water surface, and water column. The obtained results highlighted the significance of incorporating different coastal domains into oil spill responses, and the urgent demand to broaden and deepen our understanding of ecological processes across the vertical coastal zones.
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http://dx.doi.org/10.1016/j.jenvman.2021.113240DOI Listing
October 2021

SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients.

Ann Hematol 2021 Oct 16;100(10):2453-2462. Epub 2021 Jul 16.

Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet count. While corticosteroids are a useful first-line therapy for ITP patients, their long-term effectiveness is limited, and the determinants of corticosteroid sensitivity in ITP patients remain largely unknown. Sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, is related to the anti-inflammatory effects of corticosteroids. Here, we investigate the contribution of the SIRT1 single-nucleotide polymorphisms (SNPs) rs12778366 and rs4746720 to ITP susceptibility.

Methods: We recruited 330 ITP patients and 309 healthy controls from Han population, and performed genotyping of SIRT1 rs12778366 and rs4746720 using a MassARRAY system. The results were validated in another 55 ITP patients from ethnic minorities.

Results: Using clinical data of patients and controls from Han polulation, including corticosteroid sensitivity, susceptibility, refractoriness, and severity, our results revealed that the CC/TC genotypes of SIRT1 rs12778366 were associated with a 2.034-fold increased risk of corticosteroid resistance compared to the homozygous major TT genotype (dominant, CC/TC vs. TT, OR = 2.034, 95% CI = 1.039-3.984, p = 0.038). In contrast, the CC/CT genotype of SIRT1 rs4746720 showed a 0.560-fold decreased risk of corticosteroid resistance (dominant, 95% CI = 0.321-0.976, OR = 0.560, p = 0.041). The C allele substitute in SIRT1 rs12778366 was significantly associated with the corticosteroid sensitivity of ITP patients (p = 0.021). The similar results were obtained in minority ITP patients.

Conclusion: This study indicates that SIRT1 rs12778366 and rs4746720 may be genetic factors related to corticosteroid sensitivity in ITP patients.
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http://dx.doi.org/10.1007/s00277-021-04583-zDOI Listing
October 2021

The effect of in-office bleaching materials with different pH on the surface topography of bovine enamel.

Dent Mater J 2021 Jul 7. Epub 2021 Jul 7.

Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

This study evaluated the alterations of surface topography of the bovine enamel caused by different pH of in-office bleaching agents. 23% HO with pH 5.5, 7.0 and 8.5 were applied on the bovine tooth specimens (n=10) and photo-irradiated for 10 min. The bleaching procedure was repeated three times and specimens were subjected to linear surface roughness (Ra) and Vickers microhardness test (VHN) at baseline and after three consecutive applications. The morphological alterations were observed before and after third bleaching application. Data were analyzed by two-way ANOVA followed by Tukey's HSD. The pH of the bleaching agent significantly affects the Ra and VHN (p<0.05). Low pH yielded a significant increase in Ra and decrease in VHN. All the groups showed morphological alterations and profound effect was found in pH 5.5 group. It was concluded that the pH of the bleaching agent can affect Ra, VHN and surface morphology.
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http://dx.doi.org/10.4012/dmj.2021-010DOI Listing
July 2021

Characterization, Sources and Excessive Cancer Risk of PM-Bound Polycyclic Aromatic Hydrocarbons in Different Green Spaces in Lin'an, Hangzhou, China.

Bull Environ Contam Toxicol 2021 Sep 6;107(3):519-529. Epub 2021 Jul 6.

College of Landscape Architecture, Zhejiang Agriculture and Forestry University, Hangzhou, 311300, Zhejiang, China.

PM samples were collected from residential, commercial, plaza and public green spaces in Lin'an, Hangzhou, in spring (March and April) and winter (February and December) in 2017. PAHs were detected by gas chromatography-mass spectrometry (GC-MS), and their sources were identified using the diagnostic ratio (DR) and principal component analysis-multiple linear regression (PCA-MLR). The average PAH concentration in winter was 1.3 times that in spring (p < 0.01). The PAH concentrations in the green spaces decreased as commercial > residential > plaza > public green space (p < 0.05). The sources of PAHs were vehicle emissions and coal combustion pollution transported by northern Chinese air masses. Slightly higher excessive cancer risks were determined in the commercial and residential green spaces than in the plaza and public green spaces. Green coverage, pedestrian volume, traffic flow and building density greatly influenced the decrease in the PAH concentration in the green spaces. Among the 4 types of green spaces, public green space had the most ecological benefits and should be fully utilized in urban green space planning to improve public health in urban spaces.
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http://dx.doi.org/10.1007/s00128-021-03304-6DOI Listing
September 2021

Intake of processed meat, but not sodium, is associated with risk of colorectal cancer: Evidence from a large prospective cohort and two-sample Mendelian randomization.

Clin Nutr 2021 07 14;40(7):4551-4559. Epub 2021 Jun 14.

Division of Epidemiology, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; SH Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Background & Aims: Processed meat and high sodium intake are common in Western diet. The objective was to examine their independent effects on the risk of colorectal cancer (CRC).

Methods: We performed both observational analysis with UK Biobank and genetic analysis with Mendelian randomization (MR). The 24-h urinary sodium (UNa) and reported intake of processed meat were fitted on incident CRC by multivariable Cox proportional hazard model, adjusted for covariates, such as age, gender, family history, etc. Different sodium measures were used for sensitivity analyses. Two-sample MR analyses were performed using summary data from genome-wide association studies of UNa and CRC. Multivariable MR was adjusted for body mass index.

Results: We included 415 524 eligible participants from UK Biobank. During a median follow-up of 11.1 years, 2663 participants were diagnosed with CRC. High intake of processed meat independently increased risk of CRC by 23% (HR 1.23; 95% CI: 1.03 to 1.46), but 24-h UNa was not significantly associated with CRC (HR 0.96; 95% CI: 0.87 to 1.06). Furthermore, MR also showed little evidence for the effect of UNa on CRC (OR 1.02; 95% CI: 0.11 to 9.42). Sensitivity analyses showed consistent results across different measurements of sodium intake.

Conclusions: Intake of processed meat had an independent effect on the risk of CRC, but the risk was not associated with sodium level. Reduction of processed meat intake may be an effective strategy for CRC prevention, while sodium reduction should still be recommended to achieve other health benefits.
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http://dx.doi.org/10.1016/j.clnu.2021.05.036DOI Listing
July 2021

MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice.

Cell Death Discov 2021 Jun 17;7(1):165. Epub 2021 Jun 17.

Department of General Surgery, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.

Regulatory T cells (Tregs), which characteristically express forkhead box protein 3 (Foxp3), are essential for the induction of immune tolerance. Here, we investigated microRNA-146a (miR-146a), a miRNA that is widely expressed in Tregs and closely related to their homeostasis and function, with the aim of enhancing the function of Tregs by regulating miR-146a and then suppressing transplant rejection. The effect of the absence of miR-146a on Treg function in the presence or absence of rapamycin was detected in both a mouse heart transplantation model and cell co-cultures in vitro. The absence of miR-146a exerted a mild tissue-protective effect by transiently prolonging allograft survival and reducing the infiltration of CD4 and CD8 T cells into the allografts. Meanwhile, the absence of miR-146a increased Treg expansion but impaired the ability of Tregs to restrict T helper cell type 1 (Th1) responses. A miR-146a deficiency combined with interferon (IFN)-γ blockade repaired the impaired Treg function, further prolonged allograft survival, and alleviated rejection. Importantly, miR-146a regulated Tregs mainly through the IFN-γ/signal transducer and activator of transcription (STAT) 1 pathway, which is implicated in Treg function to inhibit Th1 responses. Our data suggest miR-146a controls a specific aspect of Treg function, and modulation of miR-146a may enhance Treg efficacy in alleviating heart transplant rejection in mice.
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http://dx.doi.org/10.1038/s41420-021-00534-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257678PMC
June 2021

Remarkably enhanced ion-exchange capacity of HO-intercalated layered titanate.

Chem Commun (Camb) 2021 Jul;57(60):7394-7397

School of Materials Science and Engineering, Shaanxi University of Science and Technology, Weiyang, Xi'an, Shaanxi 710021, P. R. China.

H2O2-intercalated layered titanate H1.07Ti1.73O4 (H2O2-HTO) exhibits a dramatically enhanced ion-exchange capacity and remarkably improved reaction rate with various divalent cations. The intercalation can increase the negative charge density of the TiO6 octahedral layer and the number of ion-exchangeable H+ by forming a Ti(iv)-O-O-H bond that is the driving force to change the ion exchange performance.
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http://dx.doi.org/10.1039/d1cc01387dDOI Listing
July 2021

The lncRNA PVT1 regulates autophagy in regulatory T cells to suppress heart transplant rejection in mice by targeting miR-146a.

Cell Immunol 2021 Sep 26;367:104400. Epub 2021 Jun 26.

Department of General Surgery, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China. Electronic address:

Regulatory T cells (Tregs) are indispensable for the maintenance of immune tolerance. The purpose of this study was to investigate the effect of the interaction of the lncRNA PVT1 and miR-146a on Treg autophagy and reveal the mechanism to alleviate transplant rejection. PVT1 and miR-146a expression levels were analyzed by qRT-PCR. Bioinformatic analysis and methylation profiling were used to determine the relationship between PVT1 and miR-146a. Altered autophagic status in Tregs was detected by western blotting. The effect of autophagy on Treg function was assessed in cell coculture in vitro and in animal models. Our results showed that PVT1 expression was reduced in Tregs during rejection and negatively correlated with miR-146a expression. Higher PVT1 expression was associated with higher autophagy in Tregs. Further, highly autophagic Tregs had stronger inhibitory effects on CD4 T cells in vitro, prolonged allograft survival and alleviated rejection in vivo. Mechanistic studies showed that overexpression of PVT1 enhanced TNF receptor-associated factor (TRAF) 6 expression by directly targeting miR-146a. MiR-146a overexpression reversed PVT1-induced Treg autophagy and inhibited PVT1-induced TRAF6 expression. The present study shows a novel regulatory pathway of the autophagy program that comprises PVT1, miR-146a, and TRAF6. Our findings may provide potential targets and new therapeutic strategies for transplant rejection.
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http://dx.doi.org/10.1016/j.cellimm.2021.104400DOI Listing
September 2021

Enhanced Photovoltaic Performance of BiSCl Solar Cells Through Nanorod Array.

ChemSusChem 2021 Aug 26;14(16):3351-3358. Epub 2021 Jul 26.

Department of Advanced Materials Science, Faculty of Engineering and Design, Kagawa University, 2217-20 Hayashi-cho, Takamatsu, 761-0396, Japan.

BiSCl single-crystalline nanofibers were synthesized by a facile one-pot solvothermal approach for the first time. BiSCl possesses a double chain type structure and grows readily along the c-axis, resulting the fibrous morphology. UV/Vis absorption spectroscopy revealed that BiSCl nanofibers exhibit a strong light absorption in a wavelength range from UV to visible light, corresponding to a bandgap of 1.96 eV. Ultraviolet photoelectron spectroscopy and density functional theory calculations revealed that BiSCl is a direct n-type semiconductor with valence band maximum and conduction band minimum located at 6.04 and 4.08 eV below the vacuum level, respectively. To investigate the photovoltaic performance, the homogeneous thin film of BiSCl-nanorod array was fabricated on a TiO porous film by a modified solvothermal process, where the nanorod array is oriented vertically to the surface of the TiO porous film. A proper band alignment of BiSCl-based solar cells with an architecture of fluorine-doped tin oxide (FTO)/TiO /BiSCl/(I /I )/Pt gave a PCE of 1.36 % and a relatively large short-circuit photocurrent density of 9.87 mA cm for the first time. The preliminary photovoltaic study result revealed a potential possibility of BiSCl-nanorod array as a light absorber for solar cells that can be fabricated by the low-cost solution process.
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http://dx.doi.org/10.1002/cssc.202101161DOI Listing
August 2021

Terahertz image super-resolution based on a complex convolutional neural network.

Opt Lett 2021 Jul;46(13):3123-3126

Terahertz (THz) imaging has been applied successfully in numerous applications, from medical imaging to industrial non-destructive detection. However, low resolution has always been a problem due to its long wavelength. A convolution neural network (CNN) is quite effective at improving the resolution of images in optics, in which real numbers are manipulated corresponding to measured intensity. Compared to optics, it is quite feasible to gain both the amplitude and phase information in THz imaging. In this Letter, we have extended the CNN from a real number domain to a complex number domain based on the wave nature of THz light. To the best of our knowledge, this is the first time that such a complex convolution neural network (CCNN) has been shown to be successful in THz imaging. We have proved that resolution can be 0.4 times of the beam size via this approach, and half a wavelength resolution can be obtained easily. Compared to the CNN, the CCNN generates an extra 27.8% increase in terms of contrast, implying a better image. Phase information can be recovered well, which is impossible for the CNN. Although the network is trained by the MNIST dataset, it is quite powerful for image reconstruction. Again, the CCNN outperforms the CNN in terms of generalization capability. We believe such an approach can help to overcome the lower-resolution bottleneck in THz imaging, and it can release the requirement of critical optical components and extensive fine-tuning in systems. THz biomedical imaging, non-destructive testing (NDT), and a lot of imaging applications can benefit from this approach.
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http://dx.doi.org/10.1364/OL.422684DOI Listing
July 2021

A Novel Radiomics Nomogram for the Prediction of Secondary Loss of Response to Infliximab in Crohn's Disease.

J Inflamm Res 2021 24;14:2731-2740. Epub 2021 Jun 24.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, 200127, People's Republic of China.

Purpose: The prediction of the loss of response (LOR) to infliximab (IFX) is crucial for optimizing treatment strategies and shifting biologics. However, a secondary LOR is difficult to predict by endoscopy due to the intestinal stricture, perforation, and fistulas. This study aimed to develop and validate a radiomic nomogram for the prediction of secondary LOR to IFX in patients with Crohn's disease (CD).

Patients And Methods: A total of 186 biologic-naive patients diagnosed with CD between September 2016 and June 2019 were enrolled. Secondary LOR was determined during week 54. Computed tomography enterography (CTE) texture analysis (TA) features were extracted from lesions and analyzed using LIFEx software. Feature selection was performed by least absolute shrinkage and selection operator (LASSO) and ten-fold cross validation. A nomogram was constructed using multivariable logistic regression, and the internal validation was approached by ten-fold cross validation.

Results: Predictors contained in the radiomics nomogram included three first-order and five second-order signatures. The prediction model presented significant discrimination (AUC, 0.880; 95% CI, 0.816-0.944) and high calibration (mean absolute error of = 0.028). Decision curve analysis (DCA) indicated that the nomogram provided clinical net benefit. Ten-fold cross validation assessed the stability of the nomogram with an AUC of 0.817 and an accuracy of 0.819.

Conclusion: This novel radiomics nomogram provides a predictive tool to assess secondary LOR to IFX in patients with Crohn's disease. This tool will help physicians decide when to switch therapy.
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http://dx.doi.org/10.2147/JIR.S314912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238542PMC
June 2021

Prognostic Biomarkers on a Competitive Endogenous RNA Network Reveals Overall Survival in Triple-Negative Breast Cancer.

Front Oncol 2021 11;11:681946. Epub 2021 Jun 11.

Department of Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.

The objective of this study was to construct a competitive endogenous RNA (ceRNA) regulatory network using differentially expressed long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in patients with triple-negative breast cancer (TNBC) and to construct a prognostic model for predicting overall survival (OS) in patients with TNBC. Differentially expressed lncRNAs, miRNAs, and mRNAs in TNBC patients from the TCGA and Metabric databases were examined. A prognostic model based on prognostic scores (PSs) was established for predicting OS in TNBC patients, and the performance of the model was assessed by a recipient that operated on a distinctive curve. A total of 874 differentially expressed RNAs (DERs) were screened, among which 6 lncRNAs, 295 miRNAs and 573 mRNAs were utilized to construct targeted and coexpression ceRNA regulatory networks. Eight differentially expressed genes (DEGs) associated with survival prognosis, DBX2, MYH7, TARDBP, POU4F1, ABCB11, LHFPL5, TRHDE and TIMP4, were identified by multivariate Cox regression and then used to establish a prognostic model. Our study shows that the ceRNA network has a critical role in maintaining the aggressiveness of TNBC and provides comprehensive molecular-level insight for predicting individual mortality hazards for TNBC patients. Our data suggest that these prognostic mRNAs from the ceRNA network are promising therapeutic targets for clinical intervention.
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http://dx.doi.org/10.3389/fonc.2021.681946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232227PMC
June 2021

Asymptomatic traumatic rupture of an intracranial dermoid cyst: A case report.

World J Clin Cases 2021 Jun;9(16):4046-4051

Department of Radiology, Hangzhou Ninth People's Hospital, Hangzhou 310006, Zhejiang Province, China.

Background: Previous studies reported that most of the intracranial dermoid cyst ruptures were spontaneous, and only a few were traumatic, with asymptomatic much rarer than the symptomatic ruptures. Hence, how to deal with the asymptomatic traumatic rupture of intracranial dermoid cyst remains a challenge in the clinic.

Case Summary: A 59-year-old man was accidentally diagnosed with intracranial dermoid cyst through a cranial computed tomography (CT) scan due to a car accident. A mixed-density lesion with fat and a calcified margin was observed in the midline of the posterior fossa, accompanied with lipid droplet drifts in brain sulci, fissures, cisterns, and ventricles. After 1 wk of conservative observation, no change was observed on the updated cranial CT scan. After 2 wk of conservative observation, magnetic resonance imaging examination confirmed that the lesion was a traumatic rupture of a posterior fossa dermoid cyst with lipid droplet drifts. As the patient exhibited no adverse symptoms throughout the 2 wk, a 6-mo follow-up visit was arranged for him instead of aggressive treatment. Nonetheless, the patient did not show any abnormal neurological symptoms in the 6 mo of follow-up visits.

Conclusion: Asymptomatic traumatic rupture of intracranial dermoid cyst could be just followed or treated conservatively rather than treated aggressively.
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http://dx.doi.org/10.12998/wjcc.v9.i16.4046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180201PMC
June 2021
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