Punit Marathe

Punit Marathe

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Punit Marathe

Punit Marathe

Publications by authors named "Punit Marathe"

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Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.

Mol Pharm 2019 Sep 7;16(9):4065-4076. Epub 2019 Aug 7.

Department of Metabolism and Pharmacokinetics , Bristol-Myers Squibb Research and Development , Princeton , New Jersey 08543 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00472DOI Listing
September 2019

Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy.

J Pharm Biomed Anal 2019 Jul 1;171:30-34. Epub 2019 Apr 1.

Discovery Analytical Sciences, Bristol-Myers Squibb, Route 206 & Province Line Rd, Princeton NJ 08543, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085193040
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http://dx.doi.org/10.1016/j.jpba.2019.03.066DOI Listing
July 2019

Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.

Mol Pharm 2019 06 13;16(6):2342-2353. Epub 2019 May 13.

Department of Metabolism and Pharmacokinetics , Bristol-Myers Squibb Company , Route 206 & Province Line Road , Princeton , New Jersey 08543 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01226DOI Listing
June 2019

Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

2 Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey.

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http://dx.doi.org/10.1089/neu.2018.6295DOI Listing
April 2019

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.

J Pharmacol Exp Ther 2019 Jan 25;368(1):136-145. Epub 2018 Oct 25.

Metabolism and Pharmacokinetics Department (H.S., Y.Z., J.G., P.M., W.G.H.) and Bioanalytical and Discovery Analytical Sciences Department (P.A.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Ltd., Biocon Park, Bangalore, India (V.K.H., T.T.M., P.R., S.S.G.); and Bioanalytical and Discovery Analytical Sciences Department, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., J.L.C.).

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.252643DOI Listing
January 2019

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Drug Metab Dispos 2018 02 21;46(2):178-188. Epub 2017 Nov 21.

Departments of Metabolism and Pharmacokinetics (H.S., Y.Z., X.G., W.C., J.G., Y.L., P.M., W.G.H.), Discovery Toxicology (D.M.N.), Bioanalytical and Discovery Analytical Sciences (R.V.O., C.A.M., M.D.R., P.A.S.), and Discovery Pharmaceutics (C.S.), Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, New Jersey.

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http://dx.doi.org/10.1124/dmd.117.077586DOI Listing
February 2018

Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes.

Curr Drug Metab 2017 Oct;18(8):757-768

Pharmaceutical Candidate Optimization, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pennington, NJ 08534. United States.

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http://dx.doi.org/10.2174/1389200218666170724110818DOI Listing
October 2017

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.

Drug Metab Dispos 2017 08 2;45(8):908-919. Epub 2017 Jun 2.

Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India.

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http://dx.doi.org/10.1124/dmd.117.075531DOI Listing
August 2017

Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.

J Cent Nerv Syst Dis 2017 15;9:1179573517693596. Epub 2017 Mar 15.

Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb Research & Development Center (BBRC), Bristol-Myers Squibb India Ltd, Bangalore, India.

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http://dx.doi.org/10.1177/1179573517693596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392048PMC
March 2017

Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.

J Pharmacol Exp Ther 2016 Sep 17;358(3):397-404. Epub 2016 Jun 17.

Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L., H.S., R.L., Y.C., P.S., J.D., W.G.H., P.M.); Bristol-Myers Squibb India Pvt. Ltd., Biocon Bristol-Myers Squibb Research and Development Center, Bangalore, India (Sa.M.); and Biocon BMS R&D Center, Syngene International Ltd., Bangalore, India (V.K.H., P.R., Se.M., N.G., S.S., O.D.).

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http://dx.doi.org/10.1124/jpet.116.234914DOI Listing
September 2016

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

J Med Chem 2016 09 26;59(17):7915-35. Epub 2016 Aug 26.

Immunosciences Discovery Chemistry, ‡Immunoscience Discovery Biology, §Molecular Structure and Design, Molecular Discovery Technologies, ∥Metabolism and Pharmacokinetic Department, Pharmaceutical Candidate Optimization, and ⊥ECTR/CTTO Imaging Department, Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton, New Jersey 08543, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00722DOI Listing
September 2016

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.

J Pharmacol Exp Ther 2016 May 23;357(2):382-93. Epub 2016 Feb 23.

Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey.

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http://dx.doi.org/10.1124/jpet.116.232066DOI Listing
May 2016

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Drug Metab Dispos 2016 Feb 25;44(2):238-49. Epub 2015 Nov 25.

Department of Metabolism and Pharmacokinetics (H.S., T.L., X.Q., C.C., R.M.F., A.D.R., P.M., Y.L.) and Department of Bioanalytical Sciences (H.J., C.T., K.T., H.K., J.Z.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Genomic Technologies (K.K.) and Department of Genome Biology (G.M.), Bristol-Myers Squibb Research and Development, Pennington, New Jersey; and Department of Molecular Biology (S.S., P.K.), Bristol-Myers Squibb Biocon R&D Center, Bangalore, India.

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http://dx.doi.org/10.1124/dmd.115.066852DOI Listing
February 2016

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.

J Pharmacol Exp Ther 2015 Dec 6;355(3):506-15. Epub 2015 Oct 6.

Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization (Z.Y., H.W, A.D.R., B.D.C., and P.H.M.), Department of Exploratory Clinical and Translational Research (C.A.F., R.S., S.X.Y.Z.), Department of Protein Structures and Sciences (L.A.S.), Department of Immunology Discovery (S.J.S., J.H.X., and S.G.N.), Department of Bioanalytical Sciences (J.D.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; and Department of Drug Safety Evaluation (T.W.S.), Bristol-Myers Squibb Research and Development, New Brunswick, New Jersey.

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http://jpet.aspetjournals.org/content/early/2015/10/06/jpet.
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22724
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http://dx.doi.org/10.1124/jpet.115.227249DOI Listing
December 2015

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Drug Metab Dispos 2015 Nov 4;43(11):1788-94. Epub 2015 Sep 4.

Pharmaceutical Candidate Optimization (B.L.M., H.C., L.Z., Y.Z., X.G., H.S., E.A.D., H.S., C.E.L., P.M., Y-Z.S., W.G.H., Y.L.) and Veterinary Sciences, Bristol-Myers Squibb, Princeton, New Jersey (J.G.M., M.F.)

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http://dx.doi.org/10.1124/dmd.115.065946DOI Listing
November 2015

A systematic evaluation of solubility enhancing excipients to enable the generation of permeability data for poorly soluble compounds in Caco-2 model.

Drug Metab Lett 2014 ;8(2):109-18

Pharmaceutical candidate optimization, Biocon Bristol-Myers Squibb R&D Center, Syngene International Limited, Biocon Park Plot 2 & 3, Bommasandra IV Phase, Bangalore - 560 099, India.

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October 2015

Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.

Biopharm Drug Dispos 2015 Sep 4;36(6):385-397. Epub 2015 May 4.

Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre, Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore, 560099, India.

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http://dx.doi.org/10.1002/bdd.1950DOI Listing
September 2015

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

Drug Metab Dispos 2015 Jul 22;43(7):984-93. Epub 2015 Apr 22.

Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey.

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http://dx.doi.org/10.1124/dmd.114.062364DOI Listing
July 2015

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

J Pharmacol Exp Ther 2015 May 4;353(2):380-91. Epub 2015 Mar 4.

Pharmaceutical Candidate Optimization (H.Sh., H.Su., T.L., M.Y., R.M.F., R.I., P.M., Y.L., A.D.R.), and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; and Department of Bioanalytical Service, WuXi AppTec Co., Ltd., Shanghai, People's Republic of China (L.L.).

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http://jpet.aspetjournals.org/content/353/2/380.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.114.22180
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http://dx.doi.org/10.1124/jpet.114.221804DOI Listing
May 2015

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.

Xenobiotica 2014 Dec 20;44(12):1108-16. Epub 2014 Jun 20.

Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb Research and Development Center (BBRC), Syngene International Limited , Bangalore, Karnataka , India .

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http://dx.doi.org/10.3109/00498254.2014.932470DOI Listing
December 2014

Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.

Mol Pharm 2014 Feb 9;11(2):477-85. Epub 2014 Jan 9.

Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Ltd. , Biocon Park, Plot 2 & 3, Bommasandra IV Phase, Bangalore 560 099, India.

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http://dx.doi.org/10.1021/mp400436dDOI Listing
February 2014

Factors influencing magnitude and duration of target inhibition following antibody therapy: implications in drug discovery and development.

AAPS J 2013 Jul 16;15(3):717-27. Epub 2013 Apr 16.

Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Mail Stop: 17-2.04, Pennington, NJ 08534, USA.

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http://dx.doi.org/10.1208/s12248-013-9477-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691422PMC
July 2013

Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.

Bioorg Med Chem Lett 2013 May 15;23(10):3028-33. Epub 2013 Mar 15.

Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543-4000, United States.

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http://dx.doi.org/10.1016/j.bmcl.2013.03.022DOI Listing
May 2013

Insight into tissue unbound concentration: utility in drug discovery and development.

Curr Drug Metab 2013 Mar;14(3):324-40

Pharmaceutical Candidate Optimization, Biocon Bristol Myers-Squibb R&D Centre, Syngene International Limited, Bangalore, India.

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March 2013

Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats.

Xenobiotica 2012 Nov 11;42(11):1058-68. Epub 2012 May 11.

Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Mye's Squibb Co., P.O. Box 4000, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.3109/00498254.2012.684104DOI Listing
November 2012

Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.

J Pharm Sci 2011 Jul 19;100(7):2979-88. Epub 2011 Jan 19.

Pharmaceutical Candidate Optimization: Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08540, USA.

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http://dx.doi.org/10.1002/jps.22486DOI Listing
July 2011

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

J Pharm Sci 2010 Aug;99(8):3579-93

Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/jps.22099DOI Listing
August 2010

Examination of CYP3A and P-glycoprotein-mediated drug-drug interactions using animal models.

Methods Mol Biol 2010 ;596:385-403

Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pennington, NJ, USA.

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http://link.springer.com/10.1007/978-1-60761-416-6_17
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http://dx.doi.org/10.1007/978-1-60761-416-6_17DOI Listing
January 2010

Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate.

Cancer Chemother Pharmacol 2009 Dec 26;65(1):55-66. Epub 2009 Apr 26.

Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08540, USA.

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http://link.springer.com/10.1007/s00280-009-1002-0
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http://dx.doi.org/10.1007/s00280-009-1002-0DOI Listing
December 2009

Novel tricyclic inhibitors of IkappaB kinase.

J Med Chem 2009 Apr;52(7):1994-2005

Departments of Discovery Chemistry, Discovery Biology, and Metabolism and Pharmacokinetics and Synthesis and Analysis Technology Team, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543-4000, USA.

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http://dx.doi.org/10.1021/jm8015816DOI Listing
April 2009

A liquid chromatography tandem mass spectrometry method for the quantification of indocyanine green in dog plasma and bile.

J Pharm Biomed Anal 2008 Jun 12;47(2):351-9. Epub 2008 Jan 12.

Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.1016/j.jpba.2008.01.007DOI Listing
June 2008

Projection of exposure and efficacious dose prior to first-in-human studies: how successful have we been?

Pharm Res 2008 Apr 25;25(4):713-26. Epub 2007 Sep 25.

Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., PO Box 5400, Princeton, New Jersey 08543-5400, USA.

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http://link.springer.com/content/pdf/10.1007/s11095-007-9411
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http://link.springer.com/10.1007/s11095-007-9411-4
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http://dx.doi.org/10.1007/s11095-007-9411-4DOI Listing
April 2008

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL.

Cancer Chemother Pharmacol 2008 Mar 11;61(3):365-76. Epub 2007 Apr 11.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://link.springer.com/content/pdf/10.1007/s00280-007-0478
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http://link.springer.com/10.1007/s00280-007-0478-8
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http://dx.doi.org/10.1007/s00280-007-0478-8DOI Listing
March 2008

Benzothiazole based inhibitors of p38alpha MAP kinase.

Bioorg Med Chem Lett 2008 Mar 10;18(6):1874-9. Epub 2008 Feb 10.

Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543-4000, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.02.011DOI Listing
March 2008

Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.

Drug Metab Dispos 2007 Nov 20;35(11):1990-5. Epub 2007 Aug 20.

Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myer's Squibb Co., P.O. Box 4000, Princeton, NJ 08543, USA.

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http://dmd.aspetjournals.org/content/early/2007/08/20/dmd.10
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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.107.016816
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http://dx.doi.org/10.1124/dmd.107.016816DOI Listing
November 2007

Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Bioorg Med Chem Lett 2007 May 27;17(10):2828-33. Epub 2007 Feb 27.

Department of Oncology Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-1951, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.02.050DOI Listing
May 2007

Development and validation of a preclinical food effect model.

J Pharm Sci 2007 Feb;96(2):459-72

Pharmaceutical Candidate Optimization, Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492-1951, USA.

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http://dx.doi.org/10.1002/jps.20767DOI Listing
February 2007

In vivo animal models for investigating potential CYP3A- and Pgp-mediated drug-drug interactions.

Curr Drug Metab 2006 Oct;7(7):687-704

Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, NJ 08543, USA.

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October 2006

Steady-state pharmacokinetics of a novel extended-release metformin formulation.

Clin Pharmacokinet 2005 ;44(7):721-9

Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Moreton, UK.

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http://link.springer.com/10.2165/00003088-200544070-00004
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http://dx.doi.org/10.2165/00003088-200544070-00004DOI Listing
August 2006

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog.

Cancer Chemother Pharmacol 2005 Aug 14;56(2):145-53. Epub 2005 Apr 14.

Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.1007/s00280-004-0928-5DOI Listing
August 2005

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.

Cancer Chemother Pharmacol 2005 Feb 27;55(2):110-6. Epub 2004 Aug 27.

Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA.

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http://link.springer.com/10.1007/s00280-004-0873-3
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http://dx.doi.org/10.1007/s00280-004-0873-3DOI Listing
February 2005