Prasanth R Nyalapatla

Prasanth R Nyalapatla

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Prasanth R Nyalapatla

Prasanth R Nyalapatla

Publications by authors named "Prasanth R Nyalapatla"

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16Publications

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Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes.

Chirality 2019 12 3;31(12):1014-1027. Epub 2019 Nov 3.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/chir.23144DOI Listing
December 2019

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans.

Tetrahedron 2017 Apr 17;73(14):1820-1830. Epub 2017 Feb 17.

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1016/j.tet.2017.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621746PMC
April 2017

Correction to Enantioselective Total Synthesis of (+)-Amphirionin-4.

Org Lett 2016 07 22;18(14):3509. Epub 2016 Jun 22.

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http://dx.doi.org/10.1021/acs.orglett.6b01620DOI Listing
July 2016

Enantioselective Total Synthesis of (+)-Amphirionin-4.

Org Lett 2016 05 26;18(9):2296-9. Epub 2016 Apr 26.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acs.orglett.6b00942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328589PMC
May 2016

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

Bioorg Med Chem Lett 2015 Nov 13;25(22):5072-7. Epub 2015 Oct 13.

Departments of Biochemistry and Biological Sciences, Purdue University, West Lafayette, IN, USA; Centers for Cancer Research & Drug Discovery, Purdue University, West Lafayette, IN, USA; Department of Chemistry, Purdue University, West Lafayette, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896745PMC
November 2015

A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

Antimicrob Agents Chemother 2015 May 17;59(5):2625-35. Epub 2015 Feb 17.

Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan

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http://dx.doi.org/10.1128/AAC.04757-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394833PMC
May 2015

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013