Prakash P Praharaj - National Institute of Technology Rourkela - Research Fellow

Prakash P Praharaj

National Institute of Technology Rourkela

Research Fellow

Rourkela, Odisha | India

Additional Specialties: Cancer Biologist

ORCID logohttps://orcid.org/0000-0003-0425-5118

Prakash P Praharaj - National Institute of Technology Rourkela - Research Fellow

Prakash P Praharaj

Introduction

Primary Affiliation: National Institute of Technology Rourkela - Rourkela, Odisha , India

Additional Specialties:

Research Interests:

Education

Jun 2015 - Oct 2018
National Institute of Technology Rourkela
Ph D
Department of Life Science

Experience

Feb 2017 - Jan 2017
Wake Forest Baptist Medical Center
Research Fellow
Caner Biology
Aug 2013 - May 2015
National Institute of Science Education and Research
Junior Research Fellow
Biological Sciences

Publications

16Publications

296Reads

3Profile Views

8PubMed Central Citations

Molecular interplay of autophagy and endocytosis in human health and diseases.

Biol Rev Camb Philos Soc 2019 Aug 15;94(4):1576-1590. Epub 2019 Apr 15.

Department of Life Science, National Institute of Technology Rourkela, Sundergarh, Odisha 769008, India.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/brv.12515
Publisher Site
http://dx.doi.org/10.1111/brv.12515DOI Listing
August 2019
10 Reads

Epigenetic modifications of autophagy in cancer and cancer therapeutics.

Semin Cancer Biol 2019 May 31. Epub 2019 May 31.

Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Sundergarh, Odisha, India. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.05.020DOI Listing
May 2019
13 Reads
9.330 Impact Factor

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics.

Cell Mol Life Sci 2019 May 11;76(9):1641-1652. Epub 2018 Dec 11.

Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India.

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http://link.springer.com/10.1007/s00018-018-2990-x
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http://dx.doi.org/10.1007/s00018-018-2990-xDOI Listing
May 2019
21 Reads
5.808 Impact Factor

Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy.

Cell Mol Life Sci 2019 Apr 13. Epub 2019 Apr 13.

Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India.

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http://dx.doi.org/10.1007/s00018-019-03098-1DOI Listing
April 2019
2 Reads
5.808 Impact Factor

Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients.

Cancer Med 2019 Mar 8;8(3):1110-1123. Epub 2019 Jan 8.

Cancer Biology Department, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.

African American men face a stark prostate cancer (PCa)-related health disparity, with the highest incidence and mortality rates compared to other races. Additional and innovative measures are warranted to reduce this health disparity. Here, we focused on the identification of a novel serum exosome-based "protein signature" for potential use in the early detection and better prognosis of PCa in African American men. Nanoparticle tracking analyses showed that compared to healthy individuals, exosome concentration (number/ml) was increased by ~3.2-fold (P ? 0.05) in the sera of African American men with PCa. Mass spectrometry-based proteomic analysis of serum exosomes identified seven unique and fifty-five overlapping proteins (up- or downregulated) in African Americans with PCa compared to healthy African Americans. Furthermore, ingenuity pathway analyses identified the inflammatory acute-phase response signaling as the top pathway associated with proteins loaded in exosomes from African American PCa patients. Interestingly, African American PCa E006AA-hT cells secreted exosomes strongly induced a proinflammatory M2-phenotype in macrophages and showed calcium response on sensory neurons, suggesting a neuroinflammatory response. Additionally, proteomic analyses showed that the protein Isoform 2 of Filamin A has higher loading (2.6-fold) in exosomes from African Americans with PCa, but a lesser loading (0.6-fold) was observed in exosomes from Caucasian men with PCa compared to race-matched healthy individuals. Interestingly, TCGA and Taylor's dataset as well as IHC analyses of PCa tissue showed a lower Filamin A expression in tissues of PCa patients compared with normal subjects. Overall, these results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men.

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http://doi.wiley.com/10.1002/cam4.1885
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http://dx.doi.org/10.1002/cam4.1885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434210PMC
March 2019
46 Reads

Identification and Characterization of Stem Cells in Oral Cancer.

Methods Mol Biol 2019 ;2002:129-139

Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India.

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http://dx.doi.org/10.1007/7651_2018_184DOI Listing
January 2019
4 Reads

Mitochondrial Heterogeneity in Stem Cells.

Adv Exp Med Biol 2019 ;1123:179-194

Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India.

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http://dx.doi.org/10.1007/978-3-030-11096-3_11DOI Listing
January 2019
2 Reads

Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells.

Biochem Biophys Res Commun 2018 05 9;499(4):1004-1010. Epub 2018 Apr 9.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States; Department of Urology, Wake Forest School of Medicine, United States; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929996PMC
May 2018
20 Reads
1 Citation
2.300 Impact Factor

Author Correction: Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells.

Sci Rep 2018 Apr 24;8(1):6645. Epub 2018 Apr 24.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1038/s41598-018-24997-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915453PMC
April 2018
3 Reads
5.080 Impact Factor

Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine.

Biochim Biophys Acta Rev Cancer 2018 Apr 31;1869(2):117-127. Epub 2018 Jan 31.

Wake Forest Baptist Medical Center, Department of Cancer Biology, Winston-Salem, NC, United States; Wake Forest Baptist Comprehensive Cancer Center, United States; Department of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054479PMC
April 2018
9 Reads
5 Citations
7.845 Impact Factor

Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells.

Sci Rep 2018 Mar 1;8(1):3853. Epub 2018 Mar 1.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1038/s41598-018-22068-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832762PMC
March 2018
7 Reads
2 Citations
5.080 Impact Factor

PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation.

Biochim Biophys Acta Mol Cell Res 2018 Mar 8;1865(3):480-495. Epub 2017 Dec 8.

Department of Life Science, National Institute of Technology, Rourkela, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889173031
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http://dx.doi.org/10.1016/j.bbamcr.2017.12.002DOI Listing
March 2018
5 Reads
5.019 Impact Factor

ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway.

Free Radic Biol Med 2017 03 6;104:199-213. Epub 2017 Jan 6.

Department of Life Science, National Institute of Technology, Rourkela 769008, Odisha, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849173000
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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.007DOI Listing
March 2017
15 Reads
5.736 Impact Factor

Top co-authors

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Sujit K Bhutia

National Institute of Technology

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Srimanta Patra
Srimanta Patra

National Institute of Technology Rourkela

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Kewal K Mahapatra
Kewal K Mahapatra

National Institute of Technology Rourkela

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Debasna P Panigrahi
Debasna P Panigrahi

National Institute of Technology Rourkela

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School of Pharmacy

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Prajna P Naik
Prajna P Naik

National Institute of Technology

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Bishnu P Behera
Bishnu P Behera

National Institute of Technology Rourkela

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Gati K Panigrahi

Skaggs School of Pharmacy and Pharmaceutical Sciences

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Sarbari Saha
Sarbari Saha

National Institute of Technology Rourkela

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