Publications by authors named "Prafulla C Gokhale"

46Publications

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.

Proc Natl Acad Sci U S A 2019 01 31;116(3):1027-1032. Epub 2018 Dec 31.

Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1818798116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338866PMC
January 2019

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells.

Genes Nutr 2012 Jan 13;7(1):83-9. Epub 2011 Aug 13.

Cancer Research Laboratory, Department of Biological and Environmental Sciences, University of the District of Columbia, Building 44, Room 312, 4200 Connecticut Avenue, NW, Washington, DC, 20008, USA.

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http://dx.doi.org/10.1007/s12263-011-0242-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250523PMC
January 2012

Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.

Cancer Res 2011 Mar;71(5):1573-83

Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143-0452, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077087PMC
March 2011

18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer.

Clin Cancer Res 2011 May 21;17(10):3332-40. Epub 2011 Jan 21.

Department of Biomedical Engineering, The Vanderbilt University Institute of Imaging Science, Nashville, Tennessee 37232-2310, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122480PMC
May 2011

Systemic delivery and pre-clinical evaluation of nanoparticles containing antisense oligonucleotides and siRNAs.

Methods Mol Biol 2009 ;480:65-83

Departments of Radiation Medicine and Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington D.C. 20057, USA.

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http://dx.doi.org/10.1007/978-1-59745-429-2_5DOI Listing
January 2009

Antisense oligonucleotides: target validation and development of systemically delivered therapeutic nanoparticles.

Methods Mol Biol 2007 ;361:163-85

Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1385/1-59745-208-4:163DOI Listing
March 2007

Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation.

Int J Mol Med 2007 Jan;19(1):29-39

Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.

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January 2007

Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma.

Clin Cancer Res 2006 Nov;12(22):6781-90

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, V.T. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057-1482, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0609DOI Listing
November 2006

Interaction and stabilization of X-linked inhibitor of apoptosis by Raf-1 protein kinase.

Int J Oncol 2006 Oct;29(4):861-7

Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.

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October 2006

Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells.

Int J Mol Med 2006 Mar;17(3):457-63

Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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March 2006

BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner.

J Biol Chem 2004 Jun 6;279(25):26780-8. Epub 2004 Apr 6.

Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University, Washington, D. C. 20057, USA.

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http://dx.doi.org/10.1074/jbc.M400159200DOI Listing
June 2004

Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine.

Anticancer Drugs 2004 Mar;15(3):243-53

Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1097/00001813-200403000-00009DOI Listing
March 2004

Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome.

Clin Cancer Res 2002 Nov;8(11):3611-21

Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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November 2002

A comparative study of plasma concentrations of liposomal amphotericin B (L-AMP-LRC-1) in adults, children and neonates.

Int J Pharm 2002 May;238(1-2):11-5

Department of Clinical Pharmacology, K.E.M. Hospital, Seth G.S. Medical College, Parel, Mumbai 400 012, India.

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http://dx.doi.org/10.1016/s0378-5173(02)00066-2DOI Listing
May 2002