Dr Pradeep G Kumar, PhD - Rajiv Gandhi Centre for Biotechnology - Scientist G

Dr Pradeep G Kumar

PhD

Rajiv Gandhi Centre for Biotechnology

Scientist G

Trivandrum, Kerala | India

Main Specialties: Other

Additional Specialties: Gene expression in tesits, germline stem cells

Dr Pradeep G Kumar, PhD - Rajiv Gandhi Centre for Biotechnology - Scientist G

Dr Pradeep G Kumar

PhD

Introduction

Primary Affiliation: Rajiv Gandhi Centre for Biotechnology - Trivandrum, Kerala , India

Specialties:

Additional Specialties:

Publications

91Publications

711Reads

296Profile Views

198PubMed Central Citations

Autoimmune Regulator (AIRE) Is Expressed in Spermatogenic Cells, and It Altered the Expression of Several Nucleic-Acid-Binding and Cytoskeletal Proteins in Germ Cell 1 Spermatogonial (GC1-spg) Cells.

Mol Cell Proteomics 2016 08 8;15(8):2686-98. Epub 2016 Jun 8.

From the §Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695 014, Kerala, India

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http://dx.doi.org/10.1074/mcp.M115.052951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974344PMC
August 2016
7 Reads
6.564 Impact Factor

Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis.

Biol Reprod 2016 07 1;95(1). Epub 2016 Jun 1.

Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

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http://dx.doi.org/10.1095/biolreprod.115.130369DOI Listing
July 2016
18 Reads
3.320 Impact Factor

Aberrant expression of TAR DNA binding protein-43 is associated with spermatogenic disorders in men.

Reprod Fertil Dev 2016 Apr;28(6):713-22

Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695014, Kerala, India.

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http://dx.doi.org/10.1071/RD14090DOI Listing
April 2016
11 Reads
2 Citations
2.400 Impact Factor

Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.

Mol Cell Proteomics 2015 Dec 2;14(12):3185-95. Epub 2015 Oct 2.

From the ‡Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695 014, Kerala, India;

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http://dx.doi.org/10.1074/mcp.M115.050005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762626PMC
December 2015
9 Reads
6.564 Impact Factor

Expression profiles of NPHP1 in the germ cells in the semen of men with male factor infertility.

Andrology 2015 Jul;3(4):685-93

Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

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http://dx.doi.org/10.1111/andr.12062DOI Listing
July 2015
5 Reads

Antigenic homogeneity of male Müllerian gland (MG) secretory proteins of a caecilian amphibian with secretory proteins of the mammalian prostate gland and seminal vesicles: evidence for role of the caecilian MG as a male accessory reproductive gland.

Zoology (Jena) 2014 Oct 2;117(5):319-28. Epub 2014 Aug 2.

Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, India. Electronic address:

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http://dx.doi.org/10.1016/j.zool.2014.03.005DOI Listing
October 2014
5 Reads
1.670 Impact Factor

Dramatic changes in 67 miRNAs during initiation of first wave of spermatogenesis in Mus musculus testis: global regulatory insights generated by miRNA-mRNA network analysis.

Biol Reprod 2014 Sep 13;91(3):69. Epub 2014 Aug 13.

Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

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http://dx.doi.org/10.1095/biolreprod.114.119305DOI Listing
September 2014
22 Reads
1 Citation
3.320 Impact Factor

Modulation of nicotinamide adenine dinucleotide phosphate oxidase activity through sequential posttranslational modifications of p22 phagocytic oxidase during capacitation and acrosome reaction in goat spermatozoa.

J Anim Sci 2011 Oct 6;89(10):2995-3007. Epub 2011 May 6.

Division of Molecular Reproducion, Rajiv Gandhi Centre for Biotechnology, Poojappura, Kerala, India.

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http://dx.doi.org/10.2527/jas.2010-3731DOI Listing
October 2011
30 Reads
2 Citations
2.110 Impact Factor

AIRE1A might be involved in cyclin B2 degradation in testicular lysates.

Biochem Cell Biol 2011 Aug;89(4):411-22

Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Trivandrum, Kerala, India.

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http://dx.doi.org/10.1139/o11-029DOI Listing
August 2011
18 Reads
2 Citations
2.152 Impact Factor

The role of trp ion channels in testicular function.

Adv Exp Med Biol 2011 ;704:881-908

Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, Kerela, India.

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http://link.springer.com/content/pdf/10.1007%2F978-94-007-02
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http://link.springer.com/10.1007/978-94-007-0265-3_46
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http://dx.doi.org/10.1007/978-94-007-0265-3_46DOI Listing
July 2011
6 Reads
4 Citations

Progesterone-induced reorganisation of NOX-2 components in membrane rafts is critical for sperm functioning in Capra hircus.

Andrologia 2010 Dec;42(6):356-65

Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thycaud Post, Thiruvananthapuram, Kerala, India.

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http://dx.doi.org/10.1111/j.1439-0272.2009.01024.xDOI Listing
December 2010
12 Reads
1.172 Impact Factor

Molecular characterization and expression analysis of BmNOX in two strains of Bombyx mori with contrasting viral resistance phenotype.

Arch Insect Biochem Physiol 2010 Mar;73(3):163-75

Central Sericultural Research and Training Institute, Srirampura, Mysore, India.

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http://dx.doi.org/10.1002/arch.20348DOI Listing
March 2010
5 Reads
2 Citations
1.021 Impact Factor

Distribution of N- and O-linked oligosaccharides on surface of spermatozoa from normal and infertile subjects.

Andrologia 2008 Feb;40(1):7-12

Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram, Kerala, India.

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http://dx.doi.org/10.1111/j.1439-0272.2008.00801.xDOI Listing
February 2008
20 Reads
3 Citations
1.172 Impact Factor

Fluorescence resonance energy transfer between polyphenolic compounds and riboflavin indicates a possible accessory photoreceptor function for some polyphenolic compounds.

Photochem Photobiol 2006 Sep-Oct;82(5):1358-64

Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvananthapuram 695 014, Kerala, India.

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http://dx.doi.org/10.1562/2005-08-09-RA-644DOI Listing
May 2007
6 Reads
1 Citation
2.270 Impact Factor

Identification of a soluble NADPH oxidoreductase (BmNOX) with antiviral activities in the gut juice of Bombyx mori.

Biosci Biotechnol Biochem 2007 Jan 7;71(1):200-5. Epub 2007 Jan 7.

Central Sericultural Research and Training Institute, Mysore, India.

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http://dx.doi.org/10.1271/bbb.60450DOI Listing
January 2007
27 Reads
4 Citations
1.063 Impact Factor

Profiling of E-cadherin, beta-catenin and Ca(2+) in embryo-uterine interactions at implantation.

FEBS Lett 2006 Oct 18;580(24):5653-60. Epub 2006 Sep 18.

Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvananthapuram 695014, Kerala, India.

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http://dx.doi.org/10.1016/j.febslet.2006.09.014DOI Listing
October 2006
7 Reads
5 Citations
3.170 Impact Factor

Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice.

Diabetes 2006 Mar;55(3):734-41

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th St., Augusta, GA 30912, USA.

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March 2006
20 Reads
7 Citations
8.100 Impact Factor

Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa.

Biochem Biophys Res Commun 2005 Jun;331(2):476-83

Molecular Reproduction Unit, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Trivandrum 695 014, Kerala, India.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.198DOI Listing
June 2005
7 Reads
2 Citations
2.300 Impact Factor

Mapping DNA-binding domains of the autoimmune regulator protein.

Biochem Biophys Res Commun 2005 Feb;327(3):939-44

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, CA4095, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.12.093DOI Listing
February 2005
4 Reads
13 Citations
2.300 Impact Factor

Direct involvement of hydrogen peroxide in curvature of wheat coleoptile in blue-light-treated and dark-grown coleoptiles.

Biochem Biophys Res Commun 2004 Jul;319(4):1190-6

Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Khandwa Road, Indore 452 017, M.P., India.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.102DOI Listing
July 2004
6 Reads
2.300 Impact Factor

Mifepristone (Ru486) antagonizes monocyte chemotactic protein-3 down-regulation at early mouse pregnancy revealing immunomodulatory events in Ru486 induced abortion.

Am J Reprod Immunol 2004 Jul;52(1):8-18

Embryo Implantation Group, Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, Madhya Pradesh, India.

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http://dx.doi.org/10.1111/j.1600-0897.2004.00176.xDOI Listing
July 2004
5 Reads
3 Citations
2.440 Impact Factor

Spatio-temporal organization of Vam6P and SNAP on mouse spermatozoa and their involvement in sperm-zona pellucida interactions.

Biochem Biophys Res Commun 2004 May;318(1):148-55

Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Khandwa Road, Indore 452 001, MP, India.

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http://dx.doi.org/10.1016/j.bbrc.2004.04.006DOI Listing
May 2004
6 Reads
1 Citation
2.300 Impact Factor

17Beta-estradiol induces nuclear translocation of CrkL at the window of embryo implantation.

Biochem Biophys Res Commun 2004 May;318(1):103-12

Embryo Implantation Group, Molecular Reproduction Unit, Rm. # 317-319, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Khandwa Road Campus, Indore, MP 452017, India.

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http://dx.doi.org/10.1016/j.bbrc.2004.04.005DOI Listing
May 2004
5 Reads
5 Citations
2.300 Impact Factor

Impaired E-cadherin expression in human spermatozoa in a male factor infertility subset signifies E-cadherin-mediated adhesion mechanisms operative in sperm-oolemma interactions.

Biochem Biophys Res Commun 2004 Apr;316(3):903-9

Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Khandwa Road, Indore 452 001, MP, India.

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http://dx.doi.org/10.1016/j.bbrc.2004.02.133DOI Listing
April 2004
35 Reads
2 Citations
2.300 Impact Factor

Formation and dynamic alterations of horizontal microdomains in sperm membranes during progesterone-induced acrosome reaction.

Biochem Biophys Res Commun 2004 Mar;315(3):763-70

Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Khandwa Road, Indore 452 017, MP, India.

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http://dx.doi.org/10.1016/j.bbrc.2004.01.119DOI Listing
March 2004
5 Reads
2.300 Impact Factor

A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice.

J Biol Chem 2004 Mar 29;279(12):11553-61. Epub 2003 Dec 29.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1074/jbc.M312110200DOI Listing
March 2004
29 Reads
14 Citations
4.573 Impact Factor

Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP).

Gene 2003 Mar;306:37-44

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA.

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March 2003
8 Reads
30 Citations
2.140 Impact Factor

Population genetics and functions of the autoimmune regulator (AIRE).

Endocrinol Metab Clin North Am 2002 Jun;31(2):321-38, vi

Department of Pathology, Immunology, and Laboratory Medicine, Center for Mammalian Genetics and Diabetes Center of Excellence, College of Medicine, Box 100275, University of Florida, Gainesville, FL 32610, USA.

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June 2002
4 Reads
5 Citations
3.404 Impact Factor

The autoimmune regulator (AIRE) is a DNA-binding protein.

J Biol Chem 2001 Nov 31;276(44):41357-64. Epub 2001 Aug 31.

Department of Pathology, Immunology, and Laboratory Medicine, Center for Mammalian Genetics and Diabetes Center of Excellence, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1074/jbc.M104898200DOI Listing
November 2001
4 Reads
32 Citations
4.573 Impact Factor

Sperm disposal system in spermatic granuloma: a link with superoxide radicals.

Int J Androl 2001 Oct;24(5):278-83

School of Life Sciences, Devi Ahilya University, Indore, India.

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October 2001
3 Reads
3 Citations
3.695 Impact Factor

Regional variations in thiol distribution pattern and superoxide dismutase activity of the male reproductive tract of the rat modulate the transport of spermatozoa through the epididymis and vas deferens.

Urol Int 2001 ;66(2):100-4

Urol. Int.

Contractile activity of the muscular coat of the epididymis wall is considered the major driving force for the propulsion of sperm through the male reproductive tract.
Region-specific changes in the status of membrane thiols and the free radical scavening potential of the male reproductive tract of the rat were observed.
The present study shows that the local biochemical milieu has some influence on the transport of spermatozoa through the male reproductive tract. The vas deferens showed a higher level of superoxide dismutase activity and a low profile of thiol exposure.
We conclude that the strong scavenging potential and the lesser thiol exposure of the vas create an apparently inert vas lumen which facilitates the transit of spermatozoa through the vas.

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March 2001
4 Reads

Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation.

Nitric Oxide 2000 Aug;4(4):384-91

Nitric Oxide

The aim of this study was to investigate the presence of iNOS in the murine uterus and embryo at implantation. Western blot analysis showed the presence of a 130-kDa band with strong reactivity to anti-iNOS antibody in the pre- and peri-implantation stage uteri. This band was faint in the postimplantation uteri. Immunocytochemical studies showed a heavy localization of iNOS specifically on the apical cells of the uterine endometrium in the pre- and peri-implantation stages. But the postimplantation uteri showed resorbed endometrium showing weaker expression of iNOS. The iNOS was induced by estrogen and the induction was intensified when progesterone was given along with estrogen. This truly mimics the in vivo situation since implantation in mice occurs when an estrogen surge occurs on a background of progesterone. The embryos too express iNOS at the peri-implantation stage. We suggest that iNOS expressed at peri-implantation would lead to enhanced NO production, which could act as a vasodilator and an angiogenic mediator. These effects could promote the attachment of the blastocyst to the uterus.

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August 2000
14 Reads

Altered molecular dynamics and antioxidant status in the spermatozoa in testosterone-induced oligospermia in mouse.

Mol Reprod Dev 2000 Mar;55(3):316-25

Mol. Reprod. Dev.

Though supraphysiological doses testosterone (T) and its derivatives are known to suppress spermatogenesis in mammals by interfering with the hypothalamus-pituitary axis leading to oligozoospermia, no study has been performed to evaluate the integrity of the sperm cells produced by such individuals. In T-induced oligozoospermia in the mouse, the spermatozoa showed suppressed zona-binding ability though the motility and viability remained unchanged. In order to assess whether this decreased zona-binding ability is due to perturbations in the mechanical properties of the sperm membranes, we attempted to examine the molecular dynamics employing a lipophilic spin label (16-doxyl stearate) and a protein-binding label (Mal-Net) in two sets of independent experiments. The results showed that the rotational freedom of lipophilic molecules reduced significantly within the first week of T-treatment. During weeks 1 through 4, the protein rotation was found to be retarded significantly. We observed a sharp increase in the ascorbyl radical associated with the cauda epididymal spermatozoa and epididymal fluid of testosterone-treated mice. Moreover, the glutathione (GSH) content in the spermatozoa and the epididymal fluid increased significantly after testosterone-treatment. Further, there was a elevation in the superoxide dismutase (SOD) activity and suppression in the superoxide anion radical generated by the cauda epididymal spermatozoa of testosterone-treated animals. A change in the mechanical properties of a bilayer could modify both the mechanical properties and the function of incorporated proteins. In many instances, a liquid-crystalline bilayer is necessary for protein function. It is likely that the change in the physical properties of sperm membranes might cause the inhibition of enzymes associated with spermatozoa after T-treatment. The alterations in the sperm membrane structure and the antioxidant potentials of both the spermatozoa and the cauda epididymal fluid could also account for the decrease in the zona-binding index of the spermatozoa in T-treated animals. Thus, this study demonstrates for the first time that supraphysiological doses of testosterone could modify the mechano-dynamic properties of sperm membranes and could perturb the redox status of both spermatozoa and the epididymal fluid.

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March 2000
5 Reads

NADPH dependent superoxide generation in the ovary and uterus of mice during estrous cycle and early pregnancy.

Life Sci 2000 Feb;66(12):1139-46

Life Sci.

NADPH dependent O2- production in the ovary and uterus of cycling and pregnant mice was estimated employing a novel technique of time-lapse electron spin resonance enhancement of a superoxide-trapping spin trap. The NADPH dependent O2- generation in the mouse ovary increased during the early pre-ovulatory phase in cycling females and during extended luteal phase in pregnant animals. A peak of uterine NADPH dependent O2- production at proestrous in the cycling animals at pre-implantation phase in pregnant animals suggested a contribution of this enzyme towards generating high levels of superoxide anion radical during the respective stages. Both ovarian and uterine NADPH dependent O2- production appeared to be LH-inducible.

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February 2000
4 Reads

Regional heterogeneity in intracellular distribution of superoxide and hydrogen peroxide within the sperm and its relation to sperm development.

Arch Androl 1999 Sep-Oct;43(2):113-21

Arch. Androl.

This study was performed to understand the regional distribution of superoxide anion radicals and hydrogen peroxide within the spermatozoa of mice during both normal and altered situations of epididymal maturation. The intracellular O2*- levels were probed employing dichlorodihydrofluorescein diacetate (DDF) as a reporter. The testicular spermatozoa from normal animals showed strong regional heterogeneity in the DDF fluorescence patterns over the various domains. Vasectomy resulted in strong inhibition in the O2* levels of spermatozoa at all stages of maturation. Interestingly, the fluorescein diacetate staining pattern was strong in the head of spermatozoa from the testis, caput, corpus, and cauda region. Further. there was a progressive reduction in the fluorescence in the head region in the spermatozoa toward the cauda region. The midpiece and tail showed moderate fluorescence, which also diminished as the spermatozoa matured. The spermatozoa from the vas deferens exhibited a weak fluorescence over the head domain, with the other domain staining extremely weak. Here again, vasectomy introduced considerable loss in the fluorescence intensity. The implications of programmed production of reactive oxygen species in specific domains of the spermatozoa during various stages of development are discussed.

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November 1999
5 Reads

Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa.

Asian J Androl 1999 Sep;1(3):95-107

School of Life Sciences, Devi Ahilya University, Vigyan Bhavan, Khandwa Road, Indore 452001, M.P., India.

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September 1999
3 Reads
1 Citation
2.530 Impact Factor

Effect of estradiol and selected antiestrogens on pro- and antioxidant pathways in mammalian uterus.

Contraception 1999 Aug;60(2):111-8

Contraception

In this study, we examined the effect of 17 beta-estradiol and selected antiestrogens on uterine NADPH-oxidase activity, superoxide dismutase (SOD) activity, hydride (H.-), dienyl radical and O2 -radical generation, and membrane fluidity. NADPH oxidase activity was positively modulated in estradiol-treated animals and negatively regulated in animals that received injections of AF-45, RU-39411, tamoxifen, or ICI-182780. The SOD activity was markedly reduced in estradiol-treated animals when compared with the control animals. A positive modulation of SOD activity was observed upon treatment with AF45, RU39411, tamoxifen, and ICI 182780, though the potency varied among the individual test compounds. We observed detectable H(.-)-radical generation as evidenced from MNP H.- adduct formation in the uterine cell preparations from untreated control animals. Estradiol produced a tremendous augmentation in the superoxide radical profiles in uterine cell preparations compared to the control levels. All the other compounds that were tested significantly lowered the superoxide levels in the test set-up. AF-45, RU-39411, tamoxifen, and ICI-182780 induced varying orders of suppression of H(.-)-radical generation in the test subjects. There was a significant enhancement in membrane fluidity, hydride radical levels, and dienyl radical generation in the estradiol-treated group. All the antiestrogens did not exhibit a similar action on these parameters. RU-39411 exhibited antiestrogen-like activity in modulating hydride levels and membrane fluidity, whereas it stimulated dienyl radical generation. Thus our tests showed that the selected antiestrogens failed to show estrogen-like activity in these assays. It appears that estradiol exerts feedback control over pro- and antioxidant pathways and that markers of oxidative status could be used as a measure to evaluate the antiestrogenic activity of estradiol agonists/antagonists.

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August 1999
5 Reads

Active oxygen species in blue light mediated signal transduction in coleoptile tips.

Biochem Biophys Res Commun 1999 Mar;256(2):293-8

Biochem. Biophys. Res. Commun.

Coleoptile tip is a blue-light sensitive tissue possessing a "blue light receptor" which, upon activation, elicits a signal cascade resulting in phototropic curvature of the coleoptile. In this context, the nature of the photoreceptors and the exact mechanism through which the photoreceptors transduces the signal across the membrane are not clear. In this study, we attempted to examine whether the blue light receptor perturbs redox status of the coleoptile tip and sensitizes molecular oxygen as part of the signal reactions. Coleoptile tips of Sorghum bicolor and wheat (Triticum vulgare) grown in the dark showed pronounced ascorbate free radical signal, which diminished upon illumination with weak blue light for one minute. Concomitantly, the generation of superoxide radical by the coleoptile tip was augmented upon illumination with blue light. Various thiol blockers tested in this study caused powerful inhibition of blue light induced superoxide anion radical generation. Treatment with these thiol blockers, with the exception of NEM, resulted in marked increase in the levels of ascorbic acid free radical in the blue light irradiated coleoptiles. The blue light stimulated O*-2-generation by the coleoptile tip homogenate is also inhibited by the inhibitors of blue light responses viz phenylacetic acid, potassium iodide, and sodium azide. Based on our observations, we postulate that the activated blue light receptor present in the coleoptile tip sensitizes molecular oxygen to superoxide anion radical in the tip initializing the blue light signal cascade reactions.

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March 1999
5 Reads

Bicarbonate-dependent lipid ordering and protein aggregation are part of the nongenomic action of progesterone on capacitated spermatozoa.

J Androl 1998 Sep-Oct;19(5):608-18

J. Androl.

The nongenomic action of progesterone (P) on capacitated sperm in mediating acrosomal exocytosis operates through transmembrane signal transduction involving increased intracellular calcium ions and modulation of protein kinases and phospholipid metabolism through a second messenger pathway. Conflicting views exist regarding the nature of the nongenomic receptor of P. It is thought to be a cell-surface receptor having the properties of a calcium channel, chloride channel, bicarbonate/chloride exchanger, and gamma aminobutyric acid type A (GABA(A)). In this study, we tried to understand the role of bicarbonate and/or P in inducing membrane perturbations in capacitated and acrosome-reacting spermatozoa. We also attempted to characterize the membrane responses in P-stimulated and bicuculline-poisoned sperm. The presence of a high level of bicarbonate in the medium favored high rotational mobility of lipids and proteins in capacitated sperm. However, the capacitated sperm exhibited low lipid ordering and unaltered protein ordering in response to the high bicarbonate concentration. P and bicuculline appeared to bind to the same or similar binding sites, probably a GABA(A) receptor, eliciting similar motional perturbations in sperm membranes. It appears that both P and bicuculline can induce receptor aggregation and lipid ordering in sperm membranes, which alter the capability of sperm to bind zona pellucida, and that the P action on sperm takes effect through a bicarbonate-dependent signal transduction mechanism.

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December 1998
4 Reads

Influence of a melatonin implant on the free radical load in avian thyroid and its relation with thyroid hormonogenesis.

Biochem Mol Biol Int 1998 Dec;46(6):1249-58

Biochem. Mol. Biol. Int.

The primary aim of this study was to evaluate the effect of melatonin on the oxiradical load in avian thyroid. The superoxide free radicals have been spin trapped by EPR spectroscopy in the thyroid gland of Indian rock pigeon Columbia livia following melatonin implantation for two weeks. Melatonin implantation resulted in augmentation in the levels of superoxide radical in the thyroid gland of pigeons with a concomitant decrease in the levels of the total superoxide dismutase activity. This was also associated with increased lipid peroxidation. Melatonin implantation caused a significant increase in plasma levels of glucose. Plasma levels of thyroxine (T4) and triiodothyronine (T3) were lower in the melatonin-treated pigeons. However, the T3/T4 ratio was higher following melatonin implantation. Since iodination of tyrosine is an H2O2-dependent phenomenon, the inhibition in the activity of SOD could lead to impaired thyroid hormone synthesis.

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December 1998
4 Reads

A genetic system involving superoxide causes F1 necrosis in wheat (T. aestivum L.).

Biochem Biophys Res Commun 1998 Jul;248(3):712-5

Biochem. Biophys. Res. Commun.

A genetic system in wheat is described in which F1 produced by crossing a drought tolerant cultivar C306 and high yielding cultivar WL711 exhibits leaf necrosis leading to the death of the plant. The mechanism underlying hybrid necrosis is not yet known. The hybrid exhibited a higher level of superoxide anion compared to the healthy leaves of parents at similar developmental stages. This increase in superoxide generation preceded necrotic lesion formation and displayed a gradient from the leaf tip to base. The leaf tip where necrotic lesions make their first appearance exhibited a higher level of superoxide compared to the base. Superoxide anion thus appears to play a vital role in necrosis of leaves in F1 hybrid. This genetic system can be a model system for understanding cell death in higher plants.

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July 1998
5 Reads

Starvation induced hypothyroidism involves perturbations in thyroid superoxide-SOD system in pigeons.

Biochem Mol Biol Int 1998 Jun;45(1):73-83

Department of Zoology, Govt. College Chachaura-Binagani, India.

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June 1998
3 Reads
1 Citation

Acrosome reaction inducers impose alterations in repulsive strain and hydration barrier in human sperm membranes.

Biochem Mol Biol Int 1998 Jun;45(2):227-35

Biochem. Mol. Biol. Int.

Spin labeling studies of the lipophilic domains of human spermatozoa during capacitation and during acrosome reaction (AR) under the influence of selected AR-inducers were performed. Significantly enhanced rotational function of molecules was obvious during capacitation, with no significant changes in membrane packaging or the lateral diffusion of molecules. The AR inducers appeared to restrict the rotational freedom of molecules, dramatically enhancing the lateral diffusion and ordering coefficients. A significant decrease in superoxide anion generation was observed in the acrosome reacted groups when compared to the non-acrosome reacted groups. A high level of superoxide anion radical (O2.-) level maintained in capacitated spermatozoa would add to the Van der Waal's repulsive forces at the polar head of phospholipids, holding the membrane in strain where the molecular enjoy little freedom for lateral motion. A sudden drop in the levels of O2.- in spermatozoa upon addition of AR inducers could abruptly release the local hydrophobic repulsive strain within the membrane. This loss of hydration barrier explains the observed enhancement in lateral diffusion profiles of lipids and the packaging of molecules. It is reasonable to assume that these phenomena could be amplified further by interplay of Ca2+ by modifying the local charge aggregation. Thus, we would conclude that AR inducers release the oxyradical load in capacitated spermatozoa, which would modify the repulsive strain and hydration barrier forces in the lipophilic domains permitting vesiculation of the membranes. It appears that various acrosome reaction inducers act as effectors of grossly similar physical alterations in sperm membranes and that the resulting signal cascades proceed through intercalating biochemical sequences.

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June 1998
5 Reads

Superoxide anion radical generation as a temperature stress response in the gills of freshwater catfish Heteropneustes fossilis: role in mucus exudation under elevated temperature.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1998 Feb;119(2):211-6

Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol.

Temperature induced superoxide anion radical (O2-) generation in vivo has been demonstrated in the gills of Heteropneustes fossilis by electron spin resonance (ESR) spin trapping. Temperature exposures from 25 degrees C to 37 degrees C for various times (1-4 hr) caused generation of O2- in the gill. The acid mucopolysaccharide test was conducted in gill sections during elevated temperatures. The results showed an increased activity of mucopolysaccharide in gills which indicate an increased mucus secretion in gills during elevated temperatures. The detectable stable levels of O2- in the gill at 32 and 37 degrees C temperature exposures point towards a probable role for this radical in the exudation of mucus under elevated temperature.

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February 1998
4 Reads

Superoxide anion radical mediated dissection of rat sperm: an in vitro study.

Arch Androl 1997 Sep-Oct;39(2):101-4

Department of Physiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradoon, India.

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October 1997
3 Reads

Vasectomy-induced superoxide dismutase inactivation in the male reproductive tract of rat: a prerequisite for spermatic granuloma formation.

Urol Int 1997 ;59(1):23-5

School of Life Sciences, DA University, Indore, India.

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http://dx.doi.org/10.1159/000283011DOI Listing
October 1997
2 Reads
1.151 Impact Factor

Superoxide anion radical mediated dissection of rat sperm: an in vitro study.

Arch Androl 1997 Sep-Oct;39(2):101-4

Arch. Androl.

Sperm is highly sensitive to superoxide radical surge in the granuloma interior. To investigate possibility of a superoxide radical bomb, the role of an oxyradical on the spermatozoon was studied in vitro using potassium superoxide, a potent superoxide radical producer. Results confirm that the superoxide radical has a unique site-specific scissoring power.

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October 1997
4 Reads

Free radical mediated sperm-load management in the vagina of rats.

Arch Androl 1997 Sep-Oct;39(2):127-33

Arch. Androl.

The postcoitus phagocytic engulfment of spermatozoa following disintegration of a sperm cell has not been well understood until now. By monitoring the free radical status of the vagina in accordance with the various stages of the estrous cycle and the sperm-cutting power of vaginal flushing, a positive correlation has been detected that favors the superoxide theory of the sperm-cutting technique in vivo. This finding is also consistent with the previous experience of free radical bombing of spermatozoa in spermatic granuloma.

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October 1997
4 Reads

Regulation of superoxide anion radical-superoxide dismutase system in the avian thyroid by TSH with reference to thyroid hormonogenesis.

Biochem Biophys Res Commun 1997 Oct;239(1):212-6

Biochem. Biophys. Res. Commun.

This study shows that superoxide dismutase is present in the thyroid gland of pigeons as a constitutive enzyme serving as an antioxidant against oxygen toxicity. Exogenous administration of thyrotropin induced thyroidal superoxide dismutase with a simultaneous burst in superoxide anion radical levels during the initial phase of hormone treatment. The superoxide radical generated was completely scavenged by SOD during the late phase of TSH-treatment, presumably as an adaptive measure to check the oxygen burst. TSH failed to augment serum T3 levels, although the thyroxine level in the serum was elevated. The peak level of SOD activity profile in the thyroid gland correlated very well with the peak level of thyroxine concentrations in the serum of pigeon. It is reasonable to postulate that the thyroidal SOD in homeotherms serves a dual role, firstly as a strategic antioxidant enzyme to protect the thyroid gland against the degenerative influence of toxic oxyradicals and secondly to provide H2O2 for thyroid hormone biosynthesis. Our results confirm the previous observations that TSH is mainly thyrotropic in birds and that it has no influence on the peripheral activation of thyroxine to triiodothyronine by stimulating the extra thyroidal 5'-deiodinase activity.

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October 1997
4 Reads

Activity profile of placental superoxide-superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis.

Biochem Mol Biol Int 1997 Aug;42(5):983-90

School of Life Sciences, Devi Ahilya University, Indore, India.

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August 1997
3 Reads

A programmed oxyradical burst causes hatching of mouse blastocysts.

J Cell Sci 1997 Jul;110 ( Pt 14):1597-602

School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Madhya Pradesh, India.

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July 1997
4 Reads
5 Citations
5.432 Impact Factor

Free radical-induced liquefaction of ejaculated human semen: a new dimension in semen biochemistry.

Arch Androl 1997 Mar-Apr;38(2):107-11

School of Life Sciences, Devi Ahilya Viswavidyalaya, Indore, India.

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May 1997
3 Reads
2 Citations

Characterization of a uterine luminal fluid protein ULF-250 using N-terminal microsequencing and RT-PCR identifies a novel estrogen-regulated gene in the rat uterus.

FEBS Lett 1996 Dec;399(1-2):33-6

School of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India.

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December 1996
5 Reads
3.170 Impact Factor

Estrogen surge: a regulatory switch for superoxide radical generation at implantation.

Biochem Mol Biol Int 1996 Aug;39(5):933-40

School of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India.

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August 1996
37 Reads
2 Citations

Metal binding and resultant loss of phototoxicity of alpha-terthienyl: metal detoxification versus alpha-terthienyl inactivation.

Bull Environ Contam Toxicol 1996 Feb;56(2):183-9

Sir H.N. Medical Research Society, Raja Rammohan Roy Road, Bombay, India.

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February 1996
8 Reads
1 Citation
1.255 Impact Factor

Involvement of superoxide radical in signal transduction regulating stomatal movements.

Biochem Biophys Res Commun 1994 Nov;205(1):30-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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http://dx.doi.org/10.1006/bbrc.1994.2625DOI Listing
November 1994
2 Reads
4 Citations
2.300 Impact Factor

Carbohydrate induced modulation of cell membrane. I. Interaction of sialic acid with peripheral blood lymphocytes: a spin label study.

FEBS Lett 1994 Nov;354(2):217-9

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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November 1994
4 Reads
3.170 Impact Factor

Appearance of homogeneous smectic multilamellar microenvironments in biomembranes undergoing superoxide-initiated lipid peroxidation: lipid-dienyl radical accumulation and fluidity management in lipid bilayers.

Biochem Mol Biol Int 1994 Aug;33(5):853-62

School of Life Sciences, Devi Ahilya Vishwa Vidyalaya, Indore, M.P., India.

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August 1994
4 Reads

Photochemical reaction sequences of blue light activated flavins: sensory transduction through free radical messengers.

Biochem Mol Biol Int 1994 Jun;33(3):543-51

School of Life Sciences, Devi Ahilya University, Madhya Pradesh, India.

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June 1994
3 Reads
2 Citations

Free radical bombing of spermatozoa in spermatic granuloma: an attempt to prevent autoimmune switch-on.

Biochem Biophys Res Commun 1994 May;201(1):472-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.

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http://dx.doi.org/10.1006/bbrc.1994.1725DOI Listing
May 1994
4 Reads
2 Citations
2.300 Impact Factor

Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy.

Biochem Biophys Res Commun 1994 Mar;199(3):1413-21

SIR Hurrkisondas Nurrotumdas Medical Research Society, Bombay, India.

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http://dx.doi.org/10.1006/bbrc.1994.1388DOI Listing
March 1994
5 Reads
2.300 Impact Factor

The topography of thiol distribution on sperm surface: a sensitive marker for human fertility diagnosis.

Clin Chim Acta 1994 Feb;225(1):83-4

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February 1994
4 Reads
2.824 Impact Factor

Transient thiol-expression and thiol disulphide cluster-receptor communications: a molecular basis for blastocyst-uterine interactions during implantation.

Biochem Biophys Res Commun 1994 Jan;198(1):150-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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January 1994
21 Reads
2.300 Impact Factor

Methyl xanthine and altered biomembrane dynamics: demonstration of protein mobility and enzyme inhibition by caffeine in sperm model system.

Biochem Mol Biol Int 1993 Dec;31(6):1141-8

School of Life Sciences, Indore, India.

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December 1993
3 Reads
1 Citation

Exorbitantly enhanced protein gyration and erroneous membrane modification programs in spermatozoa after vasectomy: a biophysical basis for low infertility revival after vasectomy.

Biochem Biophys Res Commun 1993 Dec;197(2):450-6

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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December 1993
3 Reads
2.300 Impact Factor

Programmed lipid peroxidation of biomembranes generating kinked phospholipids permitting local molecular mobility: a peroxidative theory of fluidity management.

Biochem Biophys Res Commun 1993 Sep;195(2):574-80

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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http://dx.doi.org/10.1006/bbrc.1993.2084DOI Listing
September 1993
32 Reads
1 Citation
2.300 Impact Factor

Lipid phase transitions and a possible lipid-protein lattice structure as an activity regulator in maturing spermatozoa.

Authors:
G P Kumar

Biochem Mol Biol Int 1993 Apr;29(6):1029-38

School of Life Sciences Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India.

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April 1993
4 Reads

Generation of superoxide anion radical by alpha-terthienyl in the anal gills of mosquito larvae Aedes aegypti: a new aspect in alpha-terthienyl phototoxicity.

Arch Insect Biochem Physiol 1992 ;19(4):261-70

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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http://dx.doi.org/10.1002/arch.940190405DOI Listing
July 1992
6 Reads
1.021 Impact Factor

ABA-induced 'lipid melting' and its reversal by umbelliferone in the plasmalemma of guard cell protoplasts: a breakthrough in plant hormone-receptor binding and hormone action.

Biochem Biophys Res Commun 1992 Jul;186(2):652-8

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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July 1992
5 Reads
1 Citation
2.300 Impact Factor

Superoxide dismutase in the anal gills of the mosquito larvae of Aedes aegypti: its inhibition by alpha-terthienyl.

Arch Insect Biochem Physiol 1991 ;16(4):249-55

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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http://dx.doi.org/10.1002/arch.940160404DOI Listing
April 1992
7 Reads
2 Citations
1.021 Impact Factor

Superoxide radical level and superoxide dismutase activity changes in maturing mammalian spermatozoa.

Andrologia 1991 Mar-Apr;23(2):171-5

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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December 1991
4 Reads
1.172 Impact Factor

Enhanced axial symmetry at the Fe(3+)-heme center of peroxidase by ascorbate: a basis for the ascorbate-dependent peroxidase action.

Biochem Biophys Res Commun 1991 Oct;180(2):597-601

School of Life Sciences, D. A. Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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October 1991
4 Reads
2.300 Impact Factor

Superoxide dismutase activation in thyroid and suppression in adrenal. Novel pituitary regulatory routes.

FEBS Lett 1991 May;282(2):310-2

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.

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May 1991
4 Reads
3.170 Impact Factor

Superoxide dismutase activity regulation by spermine: a new dimension in spermine biochemistry and sperm development.

Biochem Biophys Res Commun 1991 May;177(1):420-6

School of Life Sciences, Devi Ahilya Vishwavidyalaya, India.

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May 1991
4 Reads
1 Citation
2.300 Impact Factor

Changes in the superoxide radical and superoxide dismutase levels in the uterus of Rattus norvegicus during the estrous cycle and a possible role for superoxide radical in uterine oedema and cell proliferation at proestrus.

Biochem Cell Biol 1991 Apr;69(4):313-6

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India.

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April 1991
34 Reads
1 Citation
2.152 Impact Factor

The involvement of surface sugars of mammalian spermatozoa in epididymal maturation and in vitro sperm-zona recognition.

Andrologia 1990 Mar-Apr;22(2):184-94

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore M.P. India.

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February 1991
3 Reads
2 Citations
1.172 Impact Factor

Over-expression of superoxide dismutase and lack of surface-thiols in spermatozoa: inherent defects in oligospermia.

Biochem Biophys Res Commun 1991 Jan;174(2):510-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India.

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January 1991
4 Reads
2.300 Impact Factor

Superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis.

Biochem Biophys Res Commun 1990 Nov;173(1):302-8

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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November 1990
4 Reads
2 Citations
2.300 Impact Factor

Superoxide anion radical induces lipid phase transitions that mimic temperature-induced phase-transition phenomenon of membrane lipids.

Biochem Biophys Res Commun 1990 Oct;172(2):601-6

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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October 1990
4 Reads
2.300 Impact Factor

Activation of iodine into a free-radical intermediate by superoxide: a physiologically significant step in the iodination of tyrosine.

Biochem Biophys Res Commun 1990 Aug;170(3):1026-34

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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August 1990
5 Reads
1 Citation
2.300 Impact Factor

Powerful anti-sperm motility action of cobaltous ion and its recovery by a sulfhydryl compound.

Contraception 1990 Jun;41(6):633-9

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.

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June 1990
4 Reads
2.340 Impact Factor

Discovery of a novel and alternate hydrogen peroxide generation machinery in the mammalian thyroid gland that modulates iodination of tyrosine.

Biochem Biophys Res Commun 1990 May;169(1):1-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, India.

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May 1990
4 Reads
2.300 Impact Factor

Fluidity of the phospholipid bilayer of the endometrium at the time of implantation of the blastocyst--a spin label study.

Authors:
M Laloraya

Biochem Biophys Res Commun 1990 Mar;167(2):561-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.

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March 1990
4 Reads
4 Citations
2.300 Impact Factor

Histochemical study of superoxide dismutase in the ovary of the rat during the oestrous cycle.

J Reprod Fertil 1989 Jul;86(2):583-7

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.

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July 1989
5 Reads
3 Citations

A possible role of superoxide anion radical in the process of blastocyst implantation in Mus musculus.

Biochem Biophys Res Commun 1989 Jun;161(2):762-70

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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June 1989
4 Reads
3 Citations
2.300 Impact Factor

Coupling of a proton pump with superoxide radical-superoxide dismutase system in maturing mammalian spermatozoa and its association with sperm motility.

Biochem Biophys Res Commun 1989 Jun;161(2):771-5

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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June 1989
3 Reads
2.300 Impact Factor

The effect of some of the polyphenolic compounds on sperm motility in vitro: a structure-activity relationship.

Contraception 1989 May;39(5):531-9

School of Life Sciences, Devi Ahilya Vishwavidyalaya Indore, India.

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May 1989
36 Reads
1 Citation
2.340 Impact Factor

Changes in the levels of superoxide anion radical and superoxide dismutase during the estrous cycle of Rattus norvegicus and induction of superoxide dismutase in rat ovary by lutropin.

Biochem Biophys Res Commun 1988 Nov;157(1):146-53

School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.

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November 1988
3 Reads
5 Citations
2.300 Impact Factor