Publications by authors named "Poul H B Sorensen"

56Publications

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors.

Sci Signal 2012 Dec 18;5(255):ra92. Epub 2012 Dec 18.

Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

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http://dx.doi.org/10.1126/scisignal.2003184DOI Listing
December 2012

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis.

Apoptosis 2013 Mar;18(3):324-36

Department of Cell Biology, University of Geneva, Sciences III, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1007/s10495-012-0782-6DOI Listing
March 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

LEDGF (p75) promotes DNA-end resection and homologous recombination.

Nat Struct Mol Biol 2012 Aug 8;19(8):803-10. Epub 2012 Jul 8.

Cell Death and Metabolism, Danish Cancer Society Research Center, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nsmb.2314DOI Listing
August 2012

On translational regulation and EMT.

Semin Cancer Biol 2012 Oct 23;22(5-6):437-45. Epub 2012 Apr 23.

Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.

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http://dx.doi.org/10.1016/j.semcancer.2012.04.007DOI Listing
October 2012

Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study.

J Pathol 2012 Sep 2;228(1):119-30. Epub 2012 Jul 2.

Department of Pathology, Northwestern University Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA.

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http://dx.doi.org/10.1002/path.4010DOI Listing
September 2012

Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy.

Expert Opin Ther Targets 2012 Jan 12;16(1):33-48. Epub 2012 Jan 12.

British Columbia Cancer Research Centre , Department of Molecular Oncology, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1517/14728222.2011.638626DOI Listing
January 2012

Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancer.

Mol Cancer Res 2011 Dec 10;9(12):1755-66. Epub 2011 Oct 10.

The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.

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http://mcr.aacrjournals.org/content/early/2011/10/07/1541-77
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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-11
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http://dx.doi.org/10.1158/1541-7786.MCR-11-0379DOI Listing
December 2011

A possible role for long non-coding RNA in modulating signaling pathways.

Med Hypotheses 2011 Dec 7;77(6):962-5. Epub 2011 Sep 7.

Department of Molecular Oncology, BC Cancer Research Center, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.mehy.2011.08.020DOI Listing
December 2011

ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway.

Cancer Res 2011 Feb 9;71(3):1060-70. Epub 2010 Dec 9.

Department of Molecular Oncology, BC Cancer Research Center, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3096DOI Listing
February 2011

Ubiquitous expression of the monomeric red fluorescent protein mCherry in transgenic mice.

Genesis 2010 Dec 19;48(12):723-9. Epub 2010 Nov 19.

British Columbia Cancer Research Centre, Vancouver BC, V5Z 1L3, Canada.

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http://dx.doi.org/10.1002/dvg.20677DOI Listing
December 2010

Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma.

Oncologist 2010 17;15(6):627-35. Epub 2010 May 17.

UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, U.K.

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http://dx.doi.org/10.1634/theoncologist.2010-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227993PMC
October 2010

Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells.

Mol Cancer Ther 2010 May 27;9(5):1396-407. Epub 2010 Apr 27.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0604DOI Listing
May 2010

Reduced proliferation and enhanced migration: two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1.

Cell Cycle 2009 Sep 16;8(18):2901-6. Epub 2009 Sep 16.

Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, CA.

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http://dx.doi.org/10.4161/cc.8.18.9537DOI Listing
September 2009

Small round cell sarcomas.

Semin Oncol 2009 Aug;36(4):338-46

Huntsman Cancer Institute, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2009.06.006DOI Listing
August 2009

Sarcomas with spindle cell morphology.

Semin Oncol 2009 Aug;36(4):324-37

Department of Anatomic Pathology, IRCCS Foundation, Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1053/j.seminoncol.2009.06.007DOI Listing
August 2009

Characterization of NKIP: a novel, Na+/K+-ATPase interacting protein mediates neural differentiation and apoptosis.

Exp Cell Res 2008 Feb 24;314(3):463-77. Epub 2007 Nov 24.

Department of Clinical Pharmacology, Section of Experimental Oncology/Molecular Pharmacology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.yexcr.2007.11.013DOI Listing
February 2008

Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

J Mol Diagn 2007 Sep 9;9(4):459-63. Epub 2007 Jul 9.

Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, 600 W. 10th Ave., Vancouver, BC, Canada, V5Z 4E6.

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http://dx.doi.org/10.2353/jmoldx.2007.070009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1975098PMC
September 2007

Cellular transformation and activation of the phosphoinositide-3-kinase-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src.

Cancer Res 2007 Apr;67(7):3192-200

Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3526DOI Listing
April 2007

Y-box binding protein 1: providing a new angle on translational regulation.

Cell Cycle 2006 Jun 1;5(11):1143-7. Epub 2006 Jun 1.

Department of Pathology, Child and Family Research Institute, University of British Columbia, Canada.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.11.2784
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http://dx.doi.org/10.4161/cc.5.11.2784DOI Listing
June 2006

Classification of malignant pediatric renal tumors by gene expression.

Pediatr Blood Cancer 2006 Jun;46(7):728-38

Department of Preventive Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/pbc.20773DOI Listing
June 2006

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

Mol Cell Biol 2006 Jan;26(1):277-92

Department of Pathology, British Columbia Research Institute for Children's and Women's Health, Vancouver, BC, Canada V5Z 163.

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http://dx.doi.org/10.1128/MCB.26.1.277-292.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317623PMC
January 2006

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor.

Proc Natl Acad Sci U S A 2005 Nov 28;102(45):16239-44. Epub 2005 Oct 28.

Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.

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http://dx.doi.org/10.1073/pnas.0503137102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283417PMC
November 2005

ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.

Semin Cancer Biol 2005 Jun;15(3):215-23

Johal Program in Pediatric Oncology Basic and Translational Research, Departments of Pathology and Pediatrics, BC Research Institute for Children's and Women's Health, and the University of British Columbia, Vancouver, BC, Canada V5Z4H4.

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http://dx.doi.org/10.1016/j.semcancer.2005.01.003DOI Listing
June 2005

Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas.

Cancer Res 2004 Sep;64(17):6026-34

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-2594DOI Listing
September 2004

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

Hum Mol Genet 2004 Sep 14;13(18):2061-74. Epub 2004 Jul 14.

Department of Pathology, British Columbia Research Institute for Children's and Women's Health, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1093/hmg/ddh215DOI Listing
September 2004

Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.

Mol Cell Biol 2004 Jun;24(11):4636-50

Department of Pathology, BC Research Institute for Children's and Women's Health, 950 West 28th St., Vancouver, British Columbia V5Z 4H4, Canada.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.24.11.4636-4650.2004
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http://dx.doi.org/10.1128/MCB.24.11.4636-4650.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC416412PMC
June 2004

A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma.

Genes Chromosomes Cancer 2004 Jun;40(2):152-7

Genetic Pathology Evaluation Centre of Department of Pathology and Prostate Centre, British Columbia Cancer Agency, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/gcc.20028DOI Listing
June 2004

A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.

J Biol Chem 2004 Feb 9;279(8):6225-34. Epub 2003 Dec 9.

Department of Pathology, British Columbia Research Institute for Children's and Women's Health and the University of British Columbia, Vancouver, British Columbia V5Z4H4, Canada.

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http://dx.doi.org/10.1074/jbc.M307388200DOI Listing
February 2004

Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy.

Med Pediatr Oncol 2003 May;40(5):288-92

Oncology Department, The Children's Hospital Westmead, New South Wales, Australia.

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http://doi.wiley.com/10.1002/mpo.10272
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http://dx.doi.org/10.1002/mpo.10272DOI Listing
May 2003

Cryptic t(X;18), ins(6;18), and SYT-SSX2 gene fusion in a case of intraneural monophasic synovial sarcoma.

Cancer Genet Cytogenet 2002 Oct;138(2):153-6

Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, BC, Vancouver, Canada.

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http://dx.doi.org/10.1016/s0165-4608(02)00583-6DOI Listing
October 2002

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.

Cancer Cell 2002 Nov;2(5):367-76

Department of Pathology & Laboratory Medicine, Children's and Women's Health Centre of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia, Canada V5Z4H4.

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http://dx.doi.org/10.1016/s1535-6108(02)00180-0DOI Listing
November 2002

Desmoplastic small round cell tumor of the lung.

Arch Pathol Lab Med 2002 Oct;126(10):1226-8

Department of Pathology, University of Texas Medical Branch, Galveston 77555, USA.

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http://dx.doi.org/10.1043/0003-9985(2002)126<1226:DSRCTO>2.0.CO;2DOI Listing
October 2002

Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions.

Cancer Res 2002 Aug;62(16):4704-10

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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August 2002

ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.

Oncogene 2002 Aug;21(37):5684-95

Department of Pathology, BC Research Institute for Children's and Women's Health, and the University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1038/sj.onc.1205669DOI Listing
August 2002

ETV6 (TEL)-AML1 pre-B acute lymphoblastic leukaemia cells are associated with a distinct antigen-presenting phenotype.

Br J Haematol 2002 Feb;116(2):266-72

Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplantation, University of British Columbia and British Columbia's Children's Hospital, Vancouver, BC, Canada.

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February 2002

Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors.

Oncogene 2002 Jan;21(2):307-18

Department of Pediatrics, Children's and Women's Health Centre of British Columbia, and the University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://www.nature.com/articles/1205053
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http://dx.doi.org/10.1038/sj.onc.1205053DOI Listing
January 2002