Publications by authors named "Pomila Singh"

31Publications

Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness.

Clin Cancer Res 2019 02 16;25(4):1415-1429. Epub 2018 Nov 16.

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

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February 2019

FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer.

Mol Cancer Res 2017 12 29;15(12):1678-1691. Epub 2017 Aug 29.

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.

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December 2017

How does inflammation drive mutagenesis in colorectal cancer?

Trends Cancer Res 2017 ;12:111-132

Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas.

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January 2017

Epigenetic regulation of human gene during colon-carcinogenesis: clinical and mechanistic implications.

Stem Cell Investig 2016 28;3:51. Epub 2016 Sep 28.

Neuroscience and Cell Biology Department, University of Texas and Medical Branch, Galveston, TX, USA.

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September 2016

CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer.

Int J Cancer 2016 Apr 10;138(8):1971-81. Epub 2015 Dec 10.

Departments of Internal Medicine, Institute of Translational Science at University of Texas Medical Branch, Galveston, TX.

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April 2016

Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.

Lab Invest 2015 Nov 17;95(11):1222-33. Epub 2015 Aug 17.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.

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November 2015

Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis.

Lab Invest 2015 Jan 27;95(1):100-12. Epub 2014 Oct 27.

Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX, USA.

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January 2015

Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model.

J Control Release 2014 Jun 12;184:67-78. Epub 2014 Apr 12.

Department of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, 1520 South Martin Luther King Jr. Blvd., Tallahassee, FL 32307, USA. Electronic address:

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June 2014

Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA.

Cancer Res 2014 May 13;74(9):2487-98. Epub 2014 Mar 13.

Authors' Affiliations: Departments of Neuroscience and Cell Biology and Sealy Cancer Center, University of Texas Medical Branch Health, Galveston, Texas.

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May 2014

Real-time kinetics of high-mobility group box 1 (HMGB1) oxidation in extracellular fluids studied by in situ protein NMR spectroscopy.

J Biol Chem 2013 Apr 27;288(17):11621-7. Epub 2013 Feb 27.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1068, USA.

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April 2013

Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells.

Curr Colorectal Cancer Rep 2012 Dec;8(4):277-289

Department of Neuroscience and Cell Biology, UTMB, Galveston TX 77555.

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December 2012

Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2.

Am J Physiol Gastrointest Liver Physiol 2012 Apr 12;302(7):G712-22. Epub 2012 Jan 12.

Dept. of Neuroscience and Cell Biology, Univ. of Texas Medical Branch, Galveston, TX 77555-1043, USA.

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April 2012

Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection.

Infect Immun 2012 Feb 5;80(2):753-67. Epub 2011 Dec 5.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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February 2012

Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.

Gastroenterology 2011 Feb 6;140(2):583-595.e4. Epub 2010 Sep 6.

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1043, USA.

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February 2011

Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38.

J Biol Chem 2010 Oct 14;285(43):33485-98. Epub 2010 Aug 14.

Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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October 2010

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK.

Am J Physiol Gastrointest Liver Physiol 2010 Apr 4;298(4):G551-62. Epub 2010 Feb 4.

Dept. of Neuroscience and Cell Biology, Univ. of Texas Medical Branch, 10.104 Medical Research Bldg., 301 Univ. Blvd., Route 1043, Galveston, TX 77555-1043, USA.

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April 2010

Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin.

J Biol Chem 2009 Aug 4;284(33):22274-84. Epub 2009 Jun 4.

Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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August 2009

beta-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia.

Exp Cell Res 2009 Jan 29;315(1):97-109. Epub 2008 Oct 29.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston TX, USA.

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January 2009

Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B.

Cancer Res 2007 Aug;67(15):7266-74

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA.

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August 2007

Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS.

Neuropsychopharmacology 2007 Aug 17;32(8):1813-21. Epub 2007 Jan 17.

Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555-0431, USA.

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August 2007

Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.

Authors:
Pomila Singh

Cancer Lett 2007 Jul 22;252(1):19-35. Epub 2006 Dec 22.

Department of Neuroscience and Cell Biology, 10.104 Medical Research Building, Route 1043, University of Texas Medical Branch, 301University Blvd., Mail Route 1043, Galveston, TX 77555-1043, USA.

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July 2007

Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression.

Cancer 2005 Jun;103(12):2643-53

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1043, USA.

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June 2005

Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment.

Curr Pharm Des 2004 ;10(19):2345-58

Department of Anatomy and Neurosciences University of Texas Medical Branch Galveston, TX 77555-1043, USA.

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August 2004

Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells.

Oncogene 2004 Apr;23(14):2454-64

Department of Anatomy and Neurosciences, The University of Texas Medical Branch, Galveston, TX 77555-1043, USA.

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April 2004

Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP.

Am J Physiol Gastrointest Liver Physiol 2003 Dec 24;285(6):G1097-110. Epub 2003 Jul 24.

Department of Anatomy and Neurosciences, The University of Texas Medical Branch, Galveston, TX 77555-1043, USA.

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December 2003

Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice.

Gastroenterology 2002 Aug;123(2):516-30

Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas 77555-1043, USA.

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August 2002