Po-Ru Loh

Po-Ru Loh

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Po-Ru Loh

Po-Ru Loh

Publications by authors named "Po-Ru Loh"

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56Publications

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Authors:
Nicole M Warrington Robin N Beaumont Momoko Horikoshi Felix R Day Øyvind Helgeland Charles Laurin Jonas Bacelis Shouneng Peng Ke Hao Bjarke Feenstra Andrew R Wood Anubha Mahajan Jessica Tyrrell Neil R Robertson N William Rayner Zhen Qiao Gunn-Helen Moen Marc Vaudel Carmen J Marsit Jia Chen Michael Nodzenski Theresia M Schnurr Mohammad H Zafarmand Jonathan P Bradfield Niels Grarup Marjolein N Kooijman Ruifang Li-Gao Frank Geller Tarunveer S Ahluwalia Lavinia Paternoster Rico Rueedi Ville Huikari Jouke-Jan Hottenga Leo-Pekka Lyytikäinen Alana Cavadino Sarah Metrustry Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Natalia Vilor-Tejedor Peter K Joshi Jodie N Painter Ioanna Ntalla Ronny Myhre Niina Pitkänen Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Rebecca C Richmond Ana Espinosa Sheila J Barton Hazel M Inskip John W Holloway Loreto Santa-Marina Xavier Estivill Wei Ang Julie A Marsh Christoph Reichetzeder Letizia Marullo Berthold Hocher Kathryn L Lunetta Joanne M Murabito Caroline L Relton Manolis Kogevinas Leda Chatzi Catherine Allard Luigi Bouchard Marie-France Hivert Ge Zhang Louis J Muglia Jani Heikkinen Camilla S Morgen Antoine H C van Kampen Barbera D C van Schaik Frank D Mentch Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Gibran Hemani Susan M Ring Amanda J Bennett Kyle J Gaulton Juan Fernandez-Tajes Natalie R van Zuydam Carolina Medina-Gomez Hugoline G de Haan Frits R Rosendaal Zoltán Kutalik Pedro Marques-Vidal Shikta Das Gonneke Willemsen Hamdi Mbarek Martina Müller-Nurasyid Marie Standl Emil V R Appel Cilius E Fonvig Caecilie Trier Catharina E M van Beijsterveldt Mario Murcia Mariona Bustamante Sílvia Bonas-Guarch David M Hougaard Josep M Mercader Allan Linneberg Katharina E Schraut Penelope A Lind Sarah E Medland Beverley M Shields Bridget A Knight Jin-Fang Chai Kalliope Panoutsopoulou Meike Bartels Friman Sánchez Jakob Stokholm David Torrents Rebecca K Vinding Sara M Willems Mustafa Atalay Bo L Chawes Peter Kovacs Inga Prokopenko Marcus A Tuke Hanieh Yaghootkar Katherine S Ruth Samuel E Jones Po-Ru Loh Anna Murray Michael N Weedon Anke Tönjes Michael Stumvoll Kim F Michaelsen Aino-Maija Eloranta Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Harri Niinikoski Katja Pahkala Olli T Raitakari Bo Jacobsson Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Grant W Montgomery Harry Campbell James F Wilson Tanja G M Vrijkotte Martine Vrijheid Eco J C N de Geus M Geoffrey Hayes Haja N Kadarmideen Jens-Christian Holm Lawrence J Beilin Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Andrew T Hattersley Tim D Spector Mika Kähönen Jorma S Viikari Terho Lehtimäki Dorret I Boomsma Sylvain Sebert Peter Vollenweider Thorkild I A Sørensen Hans Bisgaard Klaus Bønnelykke Jeffrey C Murray Mads Melbye Ellen A Nohr Dennis O Mook-Kanamori Fernando Rivadeneira Albert Hofman Janine F Felix Vincent W V Jaddoe Torben Hansen Charlotta Pisinger Allan A Vaag Oluf Pedersen André G Uitterlinden Marjo-Riitta Järvelin Christine Power Elina Hyppönen Denise M Scholtens William L Lowe George Davey Smith Nicholas J Timpson Andrew P Morris Nicholas J Wareham Hakon Hakonarson Struan F A Grant Timothy M Frayling Debbie A Lawlor Pål R Njølstad Stefan Johansson Ken K Ong Mark I McCarthy John R B Perry David M Evans Rachel M Freathy

Nat Genet 2019 05 1;51(5):804-814. Epub 2019 May 1.

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/s41588-019-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522365PMC
May 2019

Genes with High Network Connectivity Are Enriched for Disease Heritability.

Am J Hum Genet 2019 May;104(5):896-913

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506868PMC
May 2019

Estimating cross-population genetic correlations of causal effect sizes.

Genet Epidemiol 2019 03 25;43(2):180-188. Epub 2018 Nov 25.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375794PMC
March 2019

Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes.

Nat Commun 2019 02 4;10(1):569. Epub 2019 Feb 4.

Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-08535-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361917PMC
February 2019

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

Am J Hum Genet 2019 Jan 27;104(1):65-75. Epub 2018 Dec 27.

Department of Epidemiology. Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323418PMC
January 2019

Author Correction: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.

Nat Genet 2018 12;50(12):1753

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/s41588-018-0284-8DOI Listing
December 2018

Mixed-model association for biobank-scale datasets.

Nat Genet 2018 07;50(7):906-908

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.nature.com/articles/s41588-018-0144-6
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http://dx.doi.org/10.1038/s41588-018-0144-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309610PMC
July 2018

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.

Nat Genet 2018 06 21;50(6):857-864. Epub 2018 May 21.

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/s41588-018-0121-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980765PMC
June 2018

Multiethnic polygenic risk scores improve risk prediction in diverse populations.

Genet Epidemiol 2017 12 7;41(8):811-823. Epub 2017 Nov 7.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.22083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726434PMC
December 2017

Heritability of Atrial Fibrillation.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA (L.-C.W., S.H.C., D.K., J.G.S. P.-R.L., M.C., C.R., O.L.H., C.N.-C., S.K., P.T.E., S.A.L.); Department of Cardiology, Clinical Sciences, Lund University, Sweden (J.G.S.); Department of Heart Failure and Valvular Disease, Skane University Hospital, Lund, Sweden (J.G.S.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (P.-R.L.); Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (K.L.L., J.D., E.J.B.); Boston University School of Public Health, Boston, MA (K.L.L., J.D., E.J.B.); Boston University School of Medicine, Boston, MA (E.J.B.); and Cardiovascular Research Center (L.-C.W., D.K., J.G.S., O.L.H., C.N.-C., S.K., P.T.E., S.A.L.) and Cardiac Arrhythmia Service (P.T.E., S.A.L.), Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966046PMC
December 2017

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Nat Commun 2017 07 12;8:16015. Epub 2017 Jul 12.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms16015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510175PMC
July 2017

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Authors:
Felix R Day Deborah J Thompson Hannes Helgason Daniel I Chasman Hilary Finucane Patrick Sulem Katherine S Ruth Sean Whalen Abhishek K Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina M Barbieri Thibaud Boutin Archie Campbell Ellen Demerath Ayush Giri Chunyan He Jouke J Hottenga Robert Karlsson Ivana Kolcic Po-Ru Loh Kathryn L Lunetta Massimo Mangino Brumat Marco George McMahon Sarah E Medland Ilja M Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M Rose Katharina E Schraut Ayellet V Segrè Albert V Smith Lisette Stolk Alexander Teumer Irene L Andrulis Stefania Bandinelli Matthias W Beckmann Javier Benitez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E Bojesen Manjeet K Bolla Judith S Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E Buring Harry Campbell Eulalia Catamo Stephen Chanock Georgia Chenevix-Trench Tanguy Corre Fergus J Couch Diana L Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J C N de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel Dos-Santos-Silva Alison M Dunning Johan G Eriksson Peter A Fasching Lindsay Fernández-Rhodes Luigi Ferrucci Dieter Flesch-Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G Giles Harald Grallert Daniel F Gudbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B Harris Catharina A Hartman Gerardo Heiss Maartje J Hooning John L Hopper Frank Hu David J Hunter M Arfan Ikram Hae Kyung Im Marjo-Riitta Järvelin Peter K Joshi David Karasik Manolis Kellis Zoltan Kutalik Genevieve LaChance Diether Lambrechts Claudia Langenberg Lenore J Launer Joop S E Laven Stefania Lenarduzzi Jingmei Li Penelope A Lind Sara Lindstrom YongMei Liu Jian'an Luan Reedik Mägi Arto Mannermaa Hamdi Mbarek Mark I McCarthy Christa Meisinger Thomas Meitinger Cristina Menni Andres Metspalu Kyriaki Michailidou Lili Milani Roger L Milne Grant W Montgomery Anna M Mulligan Mike A Nalls Pau Navarro Heli Nevanlinna Dale R Nyholt Albertine J Oldehinkel Tracy A O'Mara Sandosh Padmanabhan Aarno Palotie Nancy Pedersen Annette Peters Julian Peto Paul D P Pharoah Anneli Pouta Paolo Radice Iffat Rahman Susan M Ring Antonietta Robino Frits R Rosendaal Igor Rudan Rico Rueedi Daniela Ruggiero Cinzia F Sala Marjanka K Schmidt Robert A Scott Mitul Shah Rossella Sorice Melissa C Southey Ulla Sovio Meir Stampfer Maristella Steri Konstantin Strauch Toshiko Tanaka Emmi Tikkanen Nicholas J Timpson Michela Traglia Thérèse Truong Jonathan P Tyrer André G Uitterlinden Digna R Velez Edwards Veronique Vitart Uwe Völker Peter Vollenweider Qin Wang Elisabeth Widen Ko Willems van Dijk Gonneke Willemsen Robert Winqvist Bruce H R Wolffenbuttel Jing Hua Zhao Magdalena Zoledziewska Marek Zygmunt Behrooz Z Alizadeh Dorret I Boomsma Marina Ciullo Francesco Cucca Tõnu Esko Nora Franceschini Christian Gieger Vilmundur Gudnason Caroline Hayward Peter Kraft Debbie A Lawlor Patrik K E Magnusson Nicholas G Martin Dennis O Mook-Kanamori Ellen A Nohr Ozren Polasek David Porteous Alkes L Price Paul M Ridker Harold Snieder Tim D Spector Doris Stöckl Daniela Toniolo Sheila Ulivi Jenny A Visser Henry Völzke Nicholas J Wareham James F Wilson Amanda B Spurdle Unnur Thorsteindottir Katherine S Pollard Douglas F Easton Joyce Y Tung Jenny Chang-Claude David Hinds Anna Murray Joanne M Murabito Kari Stefansson Ken K Ong John R B Perry

Nat Genet 2017 Jun 24;49(6):834-841. Epub 2017 Apr 24.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841952PMC
June 2017

Mixed Model Association with Family-Biased Case-Control Ascertainment.

Am J Hum Genet 2017 Jan 22;100(1):31-39. Epub 2016 Dec 22.

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223022PMC
January 2017

Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure.

Am J Hum Genet 2016 Nov 20;99(5):1130-1139. Epub 2016 Oct 20.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097941PMC
November 2016

Response to Shen et al.

Am J Hum Genet 2016 11;99(5):1220-1221

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097931PMC
November 2016

Genome-wide associations for birth weight and correlations with adult disease.

Authors:
Momoko Horikoshi Robin N Beaumont Felix R Day Nicole M Warrington Marjolein N Kooijman Juan Fernandez-Tajes Bjarke Feenstra Natalie R van Zuydam Kyle J Gaulton Niels Grarup Jonathan P Bradfield David P Strachan Ruifang Li-Gao Tarunveer S Ahluwalia Eskil Kreiner Rico Rueedi Leo-Pekka Lyytikäinen Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Jouke-Jan Hottenga Natalia Vilor-Tejedor Peter K Joshi Eileen Tai Hui Boh Ioanna Ntalla Niina Pitkänen Anubha Mahajan Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Michael Nodzenski Louise A Diver Krina T Zondervan Mariona Bustamante Pedro Marques-Vidal Josep M Mercader Amanda J Bennett Nilufer Rahmioglu Dale R Nyholt Ronald Ching Wan Ma Claudia Ha Ting Tam Wing Hung Tam Santhi K Ganesh Frank Ja van Rooij Samuel E Jones Po-Ru Loh Katherine S Ruth Marcus A Tuke Jessica Tyrrell Andrew R Wood Hanieh Yaghootkar Denise M Scholtens Lavinia Paternoster Inga Prokopenko Peter Kovacs Mustafa Atalay Sara M Willems Kalliope Panoutsopoulou Xu Wang Lisbeth Carstensen Frank Geller Katharina E Schraut Mario Murcia Catharina Em van Beijsterveldt Gonneke Willemsen Emil V R Appel Cilius E Fonvig Caecilie Trier Carla Mt Tiesler Marie Standl Zoltán Kutalik Sílvia Bonas-Guarch David M Hougaard Friman Sánchez David Torrents Johannes Waage Mads V Hollegaard Hugoline G de Haan Frits R Rosendaal Carolina Medina-Gomez Susan M Ring Gibran Hemani George McMahon Neil R Robertson Christopher J Groves Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Frank D Mentch Scott M MacKenzie Rebecca M Reynolds William L Lowe Anke Tönjes Michael Stumvoll Virpi Lindi Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Thorkild Ia Sørensen Harri Niinikoski Katja Pahkala Olli T Raitakari Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Mads Melbye Harry Campbell James F Wilson Martine Vrijheid Eco Jcn de Geus Dorret I Boomsma Haja N Kadarmideen Jens-Christian Holm Torben Hansen Sylvain Sebert Andrew T Hattersley Lawrence J Beilin John P Newnham Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Mika Kähönen Jorma S Viikari Terho Lehtimäki Peter Vollenweider Klaus Bønnelykke Hans Bisgaard Dennis O Mook-Kanamori Albert Hofman Fernando Rivadeneira André G Uitterlinden Charlotta Pisinger Oluf Pedersen Christine Power Elina Hyppönen Nicholas J Wareham Hakon Hakonarson Eleanor Davies Brian R Walker Vincent Wv Jaddoe Marjo-Riitta Jarvelin Struan Fa Grant Allan A Vaag Debbie A Lawlor Timothy M Frayling George Davey Smith Andrew P Morris Ken K Ong Janine F Felix Nicholas J Timpson John Rb Perry David M Evans Mark I McCarthy Rachel M Freathy

Nature 2016 10 28;538(7624):248-252. Epub 2016 Sep 28.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/nature19806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164934PMC
October 2016

Fast and accurate long-range phasing in a UK Biobank cohort.

Nat Genet 2016 07 6;48(7):811-6. Epub 2016 Jun 6.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925291PMC
July 2016

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.

Am J Hum Genet 2016 Mar 25;98(3):456-472. Epub 2016 Feb 25.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827102PMC
March 2016

A Robust Example of Collider Bias in a Genetic Association Study.

Am J Hum Genet 2016 Feb;98(2):392-3

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746366PMC
February 2016

An atlas of genetic correlations across human diseases and traits.

Nat Genet 2015 Nov 28;47(11):1236-41. Epub 2015 Sep 28.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797329PMC
November 2015

Two-Variance-Component Model Improves Genetic Prediction in Family Datasets.

Am J Hum Genet 2015 Nov;97(5):677-90

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667134PMC
November 2015

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes.

PLoS Genet 2015 Nov 12;11(11):e1005550. Epub 2015 Nov 12.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642934PMC
November 2015

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

Am J Hum Genet 2015 Oct;97(4):576-92

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://biorxiv.org/content/biorxiv/early/2015/03/01/015859.f
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http://linkinghub.elsevier.com/retrieve/pii/S000292971500365
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596916PMC
October 2015

Mixed model with correction for case-control ascertainment increases association power.

Am J Hum Genet 2015 May 16;96(5):720-30. Epub 2015 Apr 16.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570278PMC
May 2015

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

Nat Genet 2015 Mar 2;47(3):291-5. Epub 2015 Feb 2.

1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495769PMC
March 2015

Efficient Bayesian mixed-model analysis increases association power in large cohorts.

Nat Genet 2015 Mar 2;47(3):284-90. Epub 2015 Feb 2.

1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342297PMC
March 2015

Reconstructing Austronesian population history in Island Southeast Asia.

Nat Commun 2014 Aug 19;5:4689. Epub 2014 Aug 19.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms5689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143916PMC
August 2014

Ancient west Eurasian ancestry in southern and eastern Africa.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2632-7. Epub 2014 Feb 3.

Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1313787111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932865PMC
February 2014

A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis.

BMC Bioinformatics 2013 Oct 4;14:299. Epub 2013 Oct 4.

Mathematics Department and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1186/1471-2105-14-299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851523PMC
October 2013

Genetic evidence for recent population mixture in India.

Am J Hum Genet 2013 Sep 8;93(3):422-38. Epub 2013 Aug 8.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769933PMC
September 2013

Efficient moment-based inference of admixture parameters and sources of gene flow.

Mol Biol Evol 2013 Aug 24;30(8):1788-802. Epub 2013 May 24.

Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology.

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http://dx.doi.org/10.1093/molbev/mst099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708505PMC
August 2013

Inferring admixture histories of human populations using linkage disequilibrium.

Genetics 2013 Apr 14;193(4):1233-54. Epub 2013 Feb 14.

Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1534/genetics.112.147330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606100PMC
April 2013

Compressive genomics.

Nat Biotechnol 2012 Jul 10;30(7):627-30. Epub 2012 Jul 10.

Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2241DOI Listing
July 2012

Phenotype prediction using regularized regression on genetic data in the DREAM5 Systems Genetics B Challenge.

PLoS One 2011 28;6(12):e29095. Epub 2011 Dec 28.

Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029095PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247233PMC
May 2012

Assessing statistical significance in causal graphs.

BMC Bioinformatics 2012 Feb 20;13:35. Epub 2012 Feb 20.

Computational Sciences Center of Emphasis, Pfizer Worldwide Research & Development, Cambridge, MA, USA.

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http://dx.doi.org/10.1186/1471-2105-13-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307026PMC
February 2012

Assessment of chemical mixtures and groundwater effects on Daphnia magna transcriptomics.

Environ Sci Technol 2012 Jan 5;46(1):42-50. Epub 2011 Aug 5.

Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Starkville, Mississippi, United States.

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http://dx.doi.org/10.1021/es201245bDOI Listing
January 2012

Building quantitative prediction models for tissue residue of two explosives compounds in earthworms from microarray gene expression data.

Environ Sci Technol 2012 Jan 8;46(1):19-26. Epub 2011 Aug 8.

Environmental Services, SpecPro Inc., San Antonio, Texas, United States.

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http://dx.doi.org/10.1021/es201187uDOI Listing
January 2012

Fundamental relation between phase and group velocity, and application to the failure of perfectly matched layers in backward-wave structures.

Phys Rev E Stat Nonlin Soft Matter Phys 2009 Jun 11;79(6 Pt 2):065601. Epub 2009 Jun 11.

Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1103/PhysRevE.79.065601DOI Listing
June 2009