Po Sing Leung

Po Sing Leung

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SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation.

Stem Cells 2019 11 22;37(11):1416-1428. Epub 2019 Aug 22.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1002/stem.3073DOI Listing
November 2019

Does vitamin D supplementation reduce type 2 diabetes risk?

Authors:
Po Sing Leung

Ann Transl Med 2019 Nov;7(22):614

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.21037/atm.2019.10.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944631PMC
November 2019

Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism.

Clin Sci (Lond) 2019 Oct;133(19):2029-2044

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1042/CS20190093DOI Listing
October 2019

Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters.

Int J Mol Sci 2019 Aug 21;20(17). Epub 2019 Aug 21.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.3390/ijms20174083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747176PMC
August 2019

The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the Determination of Hepatic Insulin Resistance.

Authors:
Po Sing Leung

Molecules 2019 Jul 5;24(13). Epub 2019 Jul 5.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.3390/molecules24132479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651371PMC
July 2019

Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling.

Int J Mol Sci 2019 May 22;20(10). Epub 2019 May 22.

School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.3390/ijms20102517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567208PMC
May 2019

FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential.

Authors:
Po Sing Leung

Future Med Chem 2019 04 28;11(7):641-643. Epub 2019 Mar 28.

Room 609A, Lo Kwee-Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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https://www.future-science.com/doi/10.4155/fmc-2018-0491
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http://dx.doi.org/10.4155/fmc-2018-0491DOI Listing
April 2019

GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation.

Clin Sci (Lond) 2019 01 11;133(1):101-116. Epub 2019 Jan 11.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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http://clinsci.org/lookup/doi/10.1042/CS20180836
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http://dx.doi.org/10.1042/CS20180836DOI Listing
January 2019

GPR120 is an important inflammatory regulator in the development of osteoarthritis.

Arthritis Res Ther 2018 08 3;20(1):163. Epub 2018 Aug 3.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, People's Republic of China.

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1660-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091098PMC
August 2018

Na /H exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine.

Diabetes Obes Metab 2018 03 5;20(3):709-717. Epub 2017 Dec 5.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1111/dom.13151DOI Listing
March 2018

Genetic Modification of Human Pancreatic Progenitor Cells Through Modified mRNA.

Methods Mol Biol 2016 ;1428:307-17

Department of Chemical Pathology, The Chinese University of Hong Kong, Princes of Wales Hospital, Shatin, Hong Kong, SAR, China.

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http://dx.doi.org/10.1007/978-1-4939-3625-0_21DOI Listing
December 2017

Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies.

Oncotarget 2017 Oct 10;8(49):84974-84985. Epub 2017 May 10.

School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, China.

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http://dx.doi.org/10.18632/oncotarget.17761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689587PMC
October 2017

Fibroblast growth factor 21: a regulator of metabolic disease and health span.

Am J Physiol Endocrinol Metab 2017 09 30;313(3):E292-E302. Epub 2017 May 30.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1152/ajpendo.00101.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625087PMC
September 2017

Identification and Functional Implications of Sodium/-Inositol Cotransporter 1 in Pancreatic β-Cells and Type 2 Diabetes.

Diabetes 2017 05 15;66(5):1258-1271. Epub 2017 Feb 15.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

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http://dx.doi.org/10.2337/db16-0880DOI Listing
May 2017

The potential of irisin as a therapeutic for diabetes.

Authors:
Po Sing Leung

Future Med Chem 2017 04 12;9(6):529-532. Epub 2017 Apr 12.

Lo Kwee-Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.4155/fmc-2017-0035DOI Listing
April 2017

Angiotensin II Type 2 Receptor Activation With Compound 21 Augments Islet Function and Regeneration in Streptozotocin-Induced Neonatal Rats and Human Pancreatic Progenitor Cells.

Pancreas 2017 03;46(3):395-404

From the School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1097/MPA.0000000000000754DOI Listing
March 2017

Hedgehog signaling in bone regulates whole-body energy metabolism through a bone-adipose endocrine relay mediated by PTHrP and adiponectin.

Cell Death Differ 2017 02 14;24(2):225-237. Epub 2016 Oct 14.

Ministry of Education Key Laboratories for Regenerative Medicine, School of Biomedical Sciences, Faculty of Medicine, Shatin, The Chinese University of Hong Kong, HKSAR, China.

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http://dx.doi.org/10.1038/cdd.2016.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299706PMC
February 2017

Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states.

Clin Sci (Lond) 2017 02 15;131(3):247-260. Epub 2016 Dec 15.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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http://dx.doi.org/10.1042/CS20160545DOI Listing
February 2017

Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling.

Int J Biochem Cell Biol 2016 09 21;78:237-247. Epub 2016 Jul 21.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.07.022DOI Listing
September 2016

Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus.

Med Res Rev 2016 07 31;36(4):672-704. Epub 2016 Mar 31.

School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1002/med.21390DOI Listing
July 2016

The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos.

PLoS One 2015 1;10(6):e0128216. Epub 2015 Jun 1.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128216PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452480PMC
April 2016

Combination of Telmisartan and Linagliptin Preserves Pancreatic Islet Cell Function and Morphology in db/db Mice.

Pancreas 2016 Apr;45(4):584-92

From the *School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China; and †Department of Metabolic Diseases, Boehringer-Ingelheim Pharmaceuticals, Biberach, Germany.

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http://dx.doi.org/10.1097/MPA.0000000000000505DOI Listing
April 2016

NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration Through Differentiation of Endocrine Progenitors in Murine Pancreas.

Antioxid Redox Signal 2016 Mar 18;24(8):419-33. Epub 2015 Dec 18.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Hong Kong, China .

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http://www.liebertpub.com/doi/10.1089/ars.2014.6135
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http://dx.doi.org/10.1089/ars.2014.6135DOI Listing
March 2016

The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus.

Authors:
Po Sing Leung

Nutrients 2016 Mar 5;8(3):147. Epub 2016 Mar 5.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.3390/nu8030147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808876PMC
March 2016

IL-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes.

Am J Physiol Endocrinol Metab 2016 Feb 15;310(4):E289-300. Epub 2015 Dec 15.

Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China; and

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http://dx.doi.org/10.1152/ajpendo.00356.2015DOI Listing
February 2016

Multifaceted interplay among mediators and regulators of intestinal glucose absorption: potential impacts on diabetes research and treatment.

Am J Physiol Endocrinol Metab 2015 Dec 20;309(11):E887-99. Epub 2015 Oct 20.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

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http://dx.doi.org/10.1152/ajpendo.00373.2015DOI Listing
December 2015

"Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism": Might Reduced Vitamin D Availability Due to Increases in Maternal Body Fat Contribute to This Effect?

Lipids 2015 Sep 30;50(9):837-8. Epub 2015 Jul 30.

The Blizard Institute of Cell and Molecular Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK,

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http://dx.doi.org/10.1007/s11745-015-4048-2DOI Listing
September 2015

Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.

Nutrients 2015 Sep 8;7(9):7543-61. Epub 2015 Sep 8.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.3390/nu7095352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586547PMC
September 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death.

Carcinogenesis 2015 Jun;36 Suppl 1:S89-110

Department of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea, Sultan Zainal Abidin University, Malaysia, Plant Biotechnologies Inc, St. Albert AB, Canada, Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA, Department of Urology, University of California Davis, Sacramento, CA 95817, USA, Department of Pharmacology and Toxicology, University of Vienna, Austria, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA, Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea, School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA, Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy, Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA, Department of Biology, Jackson State University, Jackson, MS 39217, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy, Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Se

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http://dx.doi.org/10.1093/carcin/bgv032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565614PMC
June 2015

Potential roles of GPR120 and its agonists in the management of diabetes.

Drug Des Devel Ther 2014 29;8:1013-27. Epub 2014 Jul 29.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.2147/DDDT.S53892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122337PMC
May 2015

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.

Mol Cell Endocrinol 2015 Mar 23;404:56-66. Epub 2015 Jan 23.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.01.029DOI Listing
March 2015

Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.

PLoS One 2014 20;9(1):e84770. Epub 2014 Jan 20.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People's Republic of China ; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China ; Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896349PMC
December 2014

Establishment of an orthotopic model of pancreatic cancer to evaluate the antitumor effects of irinotecan through the biomarker carbohydrate antigen 19-9 in mice.

Pancreas 2014 Oct;43(7):1126-8

School of Biomedical Sciences Institute of Chinese Medicine, State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong, China Institute of Chinese Medicine, State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong, China School of Biomedical Sciences Institute of Chinese Medicine, State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong, China Institute of Chinese Medicine, State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong, China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong, China

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http://dx.doi.org/10.1097/MPA.0000000000000183DOI Listing
October 2014

Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.

Int J Biochem Cell Biol 2014 Aug 27;53:224-36. Epub 2014 May 27.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.05.021DOI Listing
August 2014

Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters.

Stem Cell Rev Rep 2014 Apr;10(2):280-94

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Room 609A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, , New Territories, Hong Kong, China.

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http://dx.doi.org/10.1007/s12015-013-9491-yDOI Listing
April 2014

Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos.

Dev Dyn 2014 Mar 23;243(3):415-27. Epub 2013 Nov 23.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/dvdy.24084DOI Listing
March 2014

No evidence for a local renin-angiotensin system in liver mitochondria.

Sci Rep 2013 ;3:2467

1] Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, United Kingdom [2] Institute for Human Health and Performance, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/srep02467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747509PMC
February 2014

Mechanisms of maladaptive responses of peripheral chemoreceptors to intermittent hypoxia in sleep-disordered breathing.

Sheng Li Xue Bao 2014 Feb;66(1):23-9

Department of Physiology; Department of Anatomy; Research Centre of Heart, Brain, Hormone & Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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February 2014

Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia.

Exp Physiol 2014 Jan 13;99(1):220-31. Epub 2013 Sep 13.

M. L. Fung: Department of Physiology, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1113/expphysiol.2013.074591DOI Listing
January 2014

The role of renin-angiotensin system in cellular differentiation: implications in pancreatic islet cell development and islet transplantation.

Mol Cell Endocrinol 2013 Dec 28;381(1-2):261-71. Epub 2013 Aug 28.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.mce.2013.08.008DOI Listing
December 2013

Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport.

Am J Physiol Endocrinol Metab 2012 Sep 17;303(5):E669-81. Epub 2012 Jul 17.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1152/ajpendo.00562.2011DOI Listing
September 2012

Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells.

Int J Mol Med 2012 Jul 23;30(1):93-9. Epub 2012 Apr 23.

School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P.R. China.

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http://dx.doi.org/10.3892/ijmm.2012.980DOI Listing
July 2012

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways.

Toxicol Appl Pharmacol 2012 Jul 26;262(1):80-90. Epub 2012 Apr 26.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.taap.2012.04.021DOI Listing
July 2012

Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation.

Stem Cells 2012 Mar;30(3):525-36

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/stem.1008DOI Listing
March 2012

The Renin-angiotensin system and reactive oxygen species: implications in pancreatitis.

Antioxid Redox Signal 2011 Nov 15;15(10):2743-55. Epub 2011 Sep 15.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin New Teritories, Hong Kong, China.

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http://dx.doi.org/10.1089/ars.2011.4071DOI Listing
November 2011

Carotid Body AT(4) Receptor Expression and its Upregulation in Chronic Hypoxia.

Open Cardiovasc Med J 2007 11;1:1-7. Epub 2007 Jun 11.

Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.2174/1874192400701010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570565PMC
July 2011

Overview of the pancreas.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:3-12

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_1DOI Listing
May 2011

Physiology of the pancreas.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:13-27

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_2DOI Listing
May 2011

Common pancreatic disease.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:29-51

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_3DOI Listing
May 2011

Circulating RAS.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:55-68

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_4DOI Listing
May 2011

Local RAS.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:69-87

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_5DOI Listing
May 2011

Pancreatic RAS.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:89-105

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_6DOI Listing
May 2011

Basic techniques for pancreatic research.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:109-30

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_7DOI Listing
May 2011

Current research of the RAS in diabetes mellitus.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:131-53

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_8DOI Listing
May 2011

Current research concerning the RAS in pancreatic stem cells.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:155-77

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_9DOI Listing
May 2011

Current research of the RAS in pancreatitis and pancreatic cancer.

Authors:
Po Sing Leung

Adv Exp Med Biol 2010 ;690:179-99

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-9060-7_10DOI Listing
May 2011

Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas.

Int J Biochem Cell Biol 2011 May 23;43(5):812-20. Epub 2011 Feb 23.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2011.02.006DOI Listing
May 2011

Role of the RAS in pancreatic cancer.

Curr Cancer Drug Targets 2011 May;11(4):412-20

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.2174/156800911795538110DOI Listing
May 2011

An update on the islet renin-angiotensin system.

Peptides 2011 May 17;32(5):1087-95. Epub 2011 Mar 17.

Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1016/j.peptides.2011.03.003DOI Listing
May 2011

Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas.

Stem Cell Rev Rep 2011 Mar;7(1):53-63

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1007/s12015-010-9146-1DOI Listing
March 2011

Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro.

Regul Pept 2011 Jan 17;166(1-3):128-34. Epub 2010 Oct 17.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, China.

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http://dx.doi.org/10.1016/j.regpep.2010.10.006DOI Listing
January 2011

The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function.

Adv Exp Med Biol 2010 ;654:339-61

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1007/978-90-481-3271-3_15DOI Listing
June 2010

Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors.

Am J Physiol Cell Physiol 2010 Feb 4;298(2):C313-23. Epub 2009 Nov 4.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1152/ajpcell.00575.2008DOI Listing
February 2010

PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization.

Stem Cells Dev 2009 Sep;18(7):979-90

Department of Physiology, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1089/scd.2008.0325DOI Listing
September 2009

Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane.

Am J Physiol Cell Physiol 2009 Sep 17;297(3):C601-10. Epub 2009 Jun 17.

School of Biomedical Sciences, Faculty of Medicine, The Chinese Univ. of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://www.physiology.org/doi/10.1152/ajpcell.00135.2009
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http://dx.doi.org/10.1152/ajpcell.00135.2009DOI Listing
September 2009

Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase.

Cancer Lett 2009 Aug 14;281(1):42-52. Epub 2009 Mar 14.

Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, SAR, China.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350900118
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http://dx.doi.org/10.1016/j.canlet.2009.02.017DOI Listing
August 2009

Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells.

J Pharmacol Exp Ther 2009 May 11;329(2):450-8. Epub 2009 Feb 11.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1124/jpet.108.148353DOI Listing
May 2009

Novel peptides and proteins in diabetes mellitus.

Curr Protein Pept Sci 2009 Feb;10(1)

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http://dx.doi.org/10.2174/138920309787315185DOI Listing
February 2009

The roles of the PDZ-containing proteins bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass.

Curr Protein Pept Sci 2009 Feb;10(1):30-6

Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.2174/138920309787315248DOI Listing
February 2009

Angiotensin II in type 2 diabetes mellitus.

Curr Protein Pept Sci 2009 Feb;10(1):75-84

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.2174/138920309787315176DOI Listing
February 2009

Role of oxidative stress in pancreatic inflammation.

Antioxid Redox Signal 2009 Jan;11(1):135-65

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1089/ars.2008.2109DOI Listing
January 2009

Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent.

Org Lett 2008 Jul 17;10(14):3145-8. Epub 2008 Jun 17.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1021/ol8010503DOI Listing
July 2008

Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.

JOP 2008 May 8;9(3):290-9. Epub 2008 May 8.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong. Shatin, Hong Kong, China.

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http://pancreas.imedpub.com/effects-of-hyperglycemia-on-angi
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May 2008

Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines.

Phytother Res 2008 Apr;22(4):477-86

School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.

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http://doi.wiley.com/10.1002/ptr.2344
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http://dx.doi.org/10.1002/ptr.2344DOI Listing
April 2008

Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties.

J Nat Prod 2008 Jan 5;71(1):12-7. Epub 2008 Jan 5.

Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.1021/np070114pDOI Listing
January 2008

Angiotensin II type 1 receptor-dependent nuclear factor-kappaB activation-mediated proinflammatory actions in a rat model of obstructive acute pancreatitis.

J Pharmacol Exp Ther 2007 Oct 6;323(1):10-8. Epub 2007 Jul 6.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1124/jpet.107.124891DOI Listing
October 2007

Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane.

J Physiol 2007 Oct 16;584(Pt 2):613-23. Epub 2007 Aug 16.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1113/jphysiol.2007.138578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277173PMC
October 2007

Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury.

Clin Exp Pharmacol Physiol 2007 Oct;34(10):985-91

Department of Physiology, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1111/j.1440-1681.2007.04669.xDOI Listing
October 2007

The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas.

Pancreas 2007 Oct;35(3):e1-8

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1097/mpa.0b0013e31812eee3eDOI Listing
October 2007

Involvement of the pancreatic renin-angiotensin system in insulin resistance and the metabolic syndrome.

J Cardiometab Syndr 2006 ;1(3):197-203

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1559-4564.2006.05460.xDOI Listing
August 2007

Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice.

Antioxid Redox Signal 2007 Jul;9(7):869-78

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1089/ars.2007.1590DOI Listing
July 2007

Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro.

J Am Coll Nutr 2007 Jun;26(3):233-42

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1080/07315724.2007.10719606DOI Listing
June 2007

The physiology of a local renin-angiotensin system in the pancreas.

Authors:
Po Sing Leung

J Physiol 2007 Apr 11;580(Pt 1):31-7. Epub 2007 Jan 11.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

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http://dx.doi.org/10.1113/jphysiol.2006.126193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075423PMC
April 2007

Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies.

J Pharmacol Exp Ther 2007 Jan 12;320(1):38-46. Epub 2006 Oct 12.

School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1124/jpet.106.111526DOI Listing
January 2007

Acute pancreatitis: animal models and recent advances in basic research.

Pancreas 2007 Jan;34(1):1-14

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

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http://dx.doi.org/10.1097/01.mpa.0000246658.38375.04DOI Listing
January 2007

Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells.

J Surg Res 2006 Dec 19;136(2):325-35. Epub 2006 Oct 19.

Department of General Surgery, Peking Union Medical College Hospital, Beijing, China.

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http://dx.doi.org/10.1016/j.jss.2006.06.031DOI Listing
December 2006

Cells of the anterior pituitary.

Int J Biochem Cell Biol 2006 3;38(9):1441-9. Epub 2006 Mar 3.

Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2006.02.012DOI Listing
September 2006

Pancreatic acinar cell: its role in acute pancreatitis.

Int J Biochem Cell Biol 2006 28;38(7):1024-30. Epub 2005 Dec 28.

Department of Physiology and School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2005.12.001DOI Listing
August 2006

Novel roles of a local angiotensin-generating system in the carotid body.

Authors:
Po Sing Leung

J Physiol 2006 Aug 29;575(Pt 1). Epub 2006 Jun 29.

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, China.

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http://dx.doi.org/10.1113/jphysiol.2006.115550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819414PMC
August 2006

Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells.

Int J Biochem Cell Biol 2006 19;38(5-6):1015-22. Epub 2005 Dec 19.

Department of Biochemistry, The University of Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2005.11.012DOI Listing
May 2006

Isolation and in vitro characterization of pancreatic progenitor cells from the islets of diabetic monkey models.

Int J Biochem Cell Biol 2006 6;38(5-6):973-84. Epub 2006 Jan 6.

Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1016/j.biocel.2005.12.012DOI Listing
May 2006

Frontiers in diabetic research.

Int J Biochem Cell Biol 2006 2;38(5-6):687-8. Epub 2006 Feb 2.

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http://dx.doi.org/10.1016/j.biocel.2006.01.012DOI Listing
May 2006

Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes.

Diabetes 2006 Feb;55(2):367-74

Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories.

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http://dx.doi.org/10.2337/diabetes.55.02.06.db05-1022DOI Listing
February 2006