Pius Loetscher

Pius Loetscher

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Pius Loetscher

Pius Loetscher

Publications by authors named "Pius Loetscher"

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18Publications

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The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

iScience 2020 Feb 17;23(2):100848. Epub 2020 Jan 17.

Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC 27834, USA; Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997876PMC
February 2020

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

Eur J Pharmacol 2019 Jun 28;852:218-230. Epub 2019 Mar 28.

Department of Internal Medicine, Brody School of Medicine, East Carolina University, USA; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526936PMC
June 2019

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Bioorg Med Chem 2017 08 29;25(16):4512-4525. Epub 2017 Jun 29.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2017.06.050DOI Listing
August 2017

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

J Med Chem 2017 05 26;60(9):3672-3683. Epub 2017 Apr 26.

Global Discovery Chemistry, ‡Autoimmunity Transplantation Inflammation, §Musculoskeletal, ∥Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01703DOI Listing
May 2017

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Antimicrob Agents Chemother 2017 03 23;61(3). Epub 2017 Feb 23.

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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http://dx.doi.org/10.1128/AAC.02365-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328547PMC
March 2017

CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.

J Immunol 2014 Feb 23;192(3):886-96. Epub 2013 Dec 23.

Université Paris-Sud, Laboratoire "Cytokines, Chimiokines et Immunopathologie," Unité Mixte de Recherche S996, 92140 Clamart, France;

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http://dx.doi.org/10.4049/jimmunol.1300123DOI Listing
February 2014

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

Bioorg Med Chem Lett 2005 Dec 28;15(23):5160-4. Epub 2005 Sep 28.

Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.057DOI Listing
December 2005

Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor.

Transplantation 2005 May;79(10):1324-31

Laboratory for Transplantation Immunology, Department for Internal Medicine, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1097/01.tp.0000155429.44902.44DOI Listing
May 2005

A skin-selective homing mechanism for human immune surveillance T cells.

J Exp Med 2004 May;199(9):1265-75

Theodor-Kocher Institute, University of Bern, P.O. Box 99, CH-3000 Bern 9, Switzerland.

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http://dx.doi.org/10.1084/jem.20032177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211907PMC
May 2004

Chemokines: multiple levels of leukocyte migration control.

Trends Immunol 2004 Feb;25(2):75-84

Theodor-Kocher Institute, University of Bern, Freiestrasse 1, CH-3012 Bern, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S147149060300386
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http://dx.doi.org/10.1016/j.it.2003.12.005DOI Listing
February 2004

Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes.

FEBS Lett 2003 May;542(1-3):79-83

Theodor Kocher Institute, P.O. Box, CH-3000 9 Bern, Switzerland.

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http://dx.doi.org/10.1016/s0014-5793(03)00351-xDOI Listing
May 2003

Structure-function relationship between the human chemokine receptor CXCR3 and its ligands.

J Biol Chem 2003 Jan 1;278(1):289-95. Epub 2002 Nov 1.

Biomedical Research Centre and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1074/jbc.M209470200DOI Listing
January 2003

Homing chemokines in rheumatoid arthritis.

Arthritis Res 2002 31;4(4):233-6. Epub 2002 Jan 31.

Theodor-Kocher Institute, University of Bern, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128928PMC
http://dx.doi.org/10.1186/ar412DOI Listing
December 2002

CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses.

Trends Immunol 2002 May;23(5):250-4

Theodor-Kocher Institute, University of Bern, Freiestrasse 1, 3000 Bern 9, Switzerland.

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http://dx.doi.org/10.1016/s1471-4906(02)02218-4DOI Listing
May 2002