Piu Chan

Piu Chan

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Novel mutation in a patient with early-onset parkinsonism, progressive external ophthalmoplegia and optic atrophy.

Int J Neurosci 2019 Nov 7:1-3. Epub 2019 Nov 7.

Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, China.

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http://dx.doi.org/10.1080/00207454.2019.1681422DOI Listing
November 2019

DJ-1 is dispensable for human stem cell homeostasis.

Protein Cell 2019 Nov;10(11):846-853

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-019-00659-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834734PMC
November 2019

High-frequency rTMS over the supplementary motor area improves freezing of gait in Parkinson's disease: a randomized controlled trial.

Parkinsonism Relat Disord 2019 Nov 11;68:85-90. Epub 2019 Oct 11.

Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, Canada; Department of Medicine (Neurology), University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.parkreldis.2019.10.009DOI Listing
November 2019

Low-dose quercetin positively regulates mouse healthspan.

Protein Cell 2019 Oct;10(10):770-775

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-019-0646-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776572PMC
October 2019

Reply to the letter "Waist circumference or sarcopenic obesity; which is more predictive?"

Aging Clin Exp Res 2019 Oct 31;31(10):1539-1540. Epub 2019 Jul 31.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Xicheng District, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s40520-019-01252-0DOI Listing
October 2019

Motoric Cognitive Risk Syndrome in a Chinese Older Adult Population: Prevalence and Associated Factors.

J Am Med Dir Assoc 2019 Oct 14. Epub 2019 Oct 14.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Beijing, China; Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China; Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1016/j.jamda.2019.08.007DOI Listing
October 2019

Impaired Fine Motor Function of the Asymptomatic Hand in Unilateral Parkinson's Disease.

Front Aging Neurosci 2019 4;11:266. Epub 2019 Oct 4.

Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fnagi.2019.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787142PMC
October 2019

Visual dysfunction in patients with idiopathic rapid eye movement sleep behavior disorder.

Neurosci Lett 2019 Sep 30;709:134360. Epub 2019 Jun 30.

Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China; Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China; Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China; National Clinical Research Center for Geriatric Disorders, Beijing, China; Advanced Innovation Center For Human Brain Protection, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.134360DOI Listing
September 2019

Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study.

Brain Imaging Behav 2019 Sep 2. Epub 2019 Sep 2.

Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Street Changchun, District Xichen, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s11682-019-00169-6DOI Listing
September 2019

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.

Nat Commun 2019 07 26;10(1):3329. Epub 2019 Jul 26.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-10831-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659673PMC
July 2019

Dopaminergic pathway and primary visual cortex are involved in the freezing of gait in Parkinson's disease: a PET-CT study.

Neuropsychiatr Dis Treat 2019 10;15:1905-1914. Epub 2019 Jul 10.

The Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, People's Republic of China.

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http://dx.doi.org/10.2147/NDT.S197879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645693PMC
July 2019

Chemical screen identifies a geroprotective role of quercetin in premature aging.

Protein Cell 2019 06 1;10(6):417-435. Epub 2018 Aug 1.

Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s13238-018-0567-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538594PMC
June 2019

New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson's Disease.

Front Neurol 2019 19;10:659. Epub 2019 Jun 19.

Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fneur.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593871PMC
June 2019

Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait.

Parkinsons Dis 2019 4;2019:2196195. Epub 2019 Jun 4.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1155/2019/2196195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589230PMC
June 2019

Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.

Acta Pharmacol Sin 2019 Apr 10;40(4):441-450. Epub 2018 Jul 10.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, 100053, China.

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http://dx.doi.org/10.1038/s41401-018-0077-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461997PMC
April 2019

Postural Tremor Is Associated with Gait and Balance Impairments in Community-Dwelling Older People.

J Am Geriatr Soc 2019 Apr 19;67(4):799-803. Epub 2019 Feb 19.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

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http://dx.doi.org/10.1111/jgs.15778DOI Listing
April 2019

Concordance for Parkinson's disease in twins: A 20-year update.

Ann Neurol 2019 Apr 11;85(4):600-605. Epub 2019 Mar 11.

Department of Neurology; University of California-San Francisco, San Francisco Veterans Affairs Health Care System, University of California-San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1002/ana.25441DOI Listing
April 2019

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.

PLoS Biol 2019 04 1;17(4):e3000201. Epub 2019 Apr 1.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.pbio.3000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459557PMC
April 2019

Risk factors for cognitive impairment in older people with diabetes: a community-based study.

Ther Adv Endocrinol Metab 2019 2;10:2042018819836640. Epub 2019 Apr 2.

Department of Neurobiology, Geriatrics, and Neurology, Xuanwu Hospital, No. 45 Changchun St., Xicheng District, Beijing, China.

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http://dx.doi.org/10.1177/2042018819836640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484669PMC
April 2019

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration.

Cell Stem Cell 2019 03 17;24(3):447-461.e8. Epub 2019 Jan 17.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Brain Disorders, Beijing 100069, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183059
Publisher Site
http://dx.doi.org/10.1016/j.stem.2018.12.002DOI Listing
March 2019

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis.

Cell Rep 2019 Mar;26(13):3643-3656.e7

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.088DOI Listing
March 2019

Validation of the utility of the Brief Smell Identification Test in Chinese patients with Parkinson's disease.

J Clin Neurosci 2019 Feb 16;60:68-72. Epub 2018 Oct 16.

Department of Neurobiology and Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing 100053, China; Beijing Key Laboratory on Parkinson's Disease, Beijing 100053, China. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2018.10.023DOI Listing
February 2019

Decreased subregional specificity of the putamen in Parkinson's Disease revealed by dynamic connectivity-derived parcellation.

Neuroimage Clin 2018 23;20:1163-1175. Epub 2018 Oct 23.

Pacific Parkinson's Research Centre, Vancouver, Canada; Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada; Graduate Program in Neuroscience, University of British Columbia, Vancouver, Canada; Department of Medicine (Neurology), University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.nicl.2018.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214880PMC
February 2019

Connectome-wide network analysis of white matter connectivity in Alzheimer's disease.

Neuroimage Clin 2019 21;22:101690. Epub 2019 Feb 21.

Department of Electronic and Information Engineering, Harbin Institute of Technology at Shenzhen, Shenzhen, Guangdong Province, China; Peng Cheng Laboratory, Shenzhen, Guangdong, China; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396432PMC
February 2019

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes.

Diabetes Metab Syndr Obes 2019 9;12:121-130. Epub 2019 Jan 9.

National Clinical Research Center for Geriatric Disorders, Beijing 100053, China,

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http://dx.doi.org/10.2147/DMSO.S180781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330976PMC
January 2019

Prevalence of pre-diagnostic symptoms did not differ between LRRK2-related, GBA-related and idiopathic patients with Parkinson's disease.

Parkinsonism Relat Disord 2018 12 14;57:72-76. Epub 2018 Aug 14.

Department of Neurobiology, Neurology, and Geriatrics, Xuanwu Hospital Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Disorders, Beijing, China; Key Laboratories of Ministry of Education for Neurodegenerative Diseases, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing Key Laboratory on Parkinson's Disease, China. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.08.007DOI Listing
December 2018

Management Recommendations on Sleep Disturbance of Patients with Parkinson's Disease.

Chin Med J (Engl) 2018 Dec;131(24):2976-2985

National Parkinson Foundation Centre of Excellence and The Maurice Wohl Clinical Neuroscience Institute, King's College London and King's College Hospital, London WC2R 2LS, UK.

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http://dx.doi.org/10.4103/0366-6999.247210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302643PMC
December 2018

Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing.

Aging Clin Exp Res 2018 Nov 27;30(11):1319-1325. Epub 2018 Mar 27.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Xicheng District, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s40520-018-0933-xDOI Listing
November 2018

Impaired serial ordering in nondemented patients with mild Parkinson's disease.

PLoS One 2018 16;13(5):e0197489. Epub 2018 May 16.

CAS Key Laboratory of Mental Healthy, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955595PMC
November 2018

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells.

Protein Cell 2018 11 2;9(11):945-965. Epub 2018 Jul 2.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://link.springer.com/10.1007/s13238-018-0560-5
Publisher Site
http://dx.doi.org/10.1007/s13238-018-0560-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208479PMC
November 2018

Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease.

J Neuroradiol 2018 Jul 19;45(4):249-255. Epub 2017 Dec 19.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China; Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China; Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China; National Clinical Research Center for Geriatrics Disorders, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurad.2017.11.008DOI Listing
July 2018

An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain.

J Neurosci Methods 2018 07 23;304:83-91. Epub 2018 Apr 23.

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 10090, China. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2018.04.015DOI Listing
July 2018

LRRK2-associated Parkinson's disease patients have better stereopsis than idiopathic Parkinson disease.

Authors:
Liang Sun Piu Chan

Clin Neurol Neurosurg 2018 06 22;169:174-177. Epub 2018 Apr 22.

Department of Neurobiology and Neurology, Xuanwu Hospital of Capital MedicalUniversity, Beijing, China; National Clinical Research Center for Geriatric Disorders, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2018.04.016DOI Listing
June 2018

Postural sway in patients with early Parkinson's disease performing cognitive tasks while standing.

Neurol Res 2018 Jun 5;40(6):491-498. Epub 2018 Jun 5.

c Department of Neurology , Provincial Hospital Affiliated to Shandong University , Jinan , China.

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http://dx.doi.org/10.1080/01616412.2018.1451017DOI Listing
June 2018

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome.

Protein Cell 2018 04 23;9(4):333-350. Epub 2018 Feb 23.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-018-0517-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876188PMC
April 2018

The Corticostriatal Adenosine A Receptor Controls Maintenance and Retrieval of Spatial Working Memory.

Biol Psychiatry 2018 03 1;83(6):530-541. Epub 2017 Aug 1.

Molecular Pharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China; Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.07.017DOI Listing
March 2018

Prevalence of Frailty and Associated Factors in the Community-Dwelling Population of China.

J Am Geriatr Soc 2018 03 23;66(3):559-564. Epub 2017 Nov 23.

Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China National Clinical Research Center for Geriatric Medicine, Beijing, China.

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http://dx.doi.org/10.1111/jgs.15214DOI Listing
March 2018

Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients.

Neurosci Lett 2018 03 17;668:115-119. Epub 2018 Jan 17.

Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing 100053, PR China; Department of Biobank, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing 100053, PR China; Laboratory of Chronobiology and Chronomedicine, Beijing Geriatric Medical Research Center, Beijing 100053, PR China; National Clinical Research Center for Geriatric Disorders, Beijing 100053, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2018.01.027DOI Listing
March 2018

Author Correction: Altered resting-state brain activity in Parkinson's disease patients with freezing of gait.

Sci Rep 2018 Mar 14;8(1):4792. Epub 2018 Mar 14.

Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.

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http://dx.doi.org/10.1038/s41598-018-23233-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852029PMC
March 2018

Parkinson disease with constipation: clinical features and relevant factors.

Sci Rep 2018 01 12;8(1):567. Epub 2018 Jan 12.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

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http://dx.doi.org/10.1038/s41598-017-16790-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766597PMC
January 2018

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells.

Cell Discov 2018 5;4. Epub 2018 Jan 5.

1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China.

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http://dx.doi.org/10.1038/s41421-017-0003-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798892PMC
January 2018

Altered resting-state brain activity in Parkinson's disease patients with freezing of gait.

Sci Rep 2017 12 1;7(1):16711. Epub 2017 Dec 1.

Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.

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http://dx.doi.org/10.1038/s41598-017-16922-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711935PMC
December 2017

Cognitive Frailty in China: Results from China Comprehensive Geriatric Assessment Study.

Front Med (Lausanne) 2017 20;4:174. Epub 2017 Oct 20.

Department of Geriatrics, Beijing Geriatric Healthcare Center, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fmed.2017.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655005PMC
October 2017

Motoric Cognitive Risk Syndrome: Predictor of Dementia and Age-Related Negative Outcomes.

Front Med (Lausanne) 2017 25;4:166. Epub 2017 Oct 25.

Gérontopôle, Department of Geriatrics, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.3389/fmed.2017.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660976PMC
October 2017

Clinical Manifestation of Parkinson's Disease in Association with Rapid Eye Movement Sleep Behavior Disorder Onset.

Eur Neurol 2016 9;76(3-4):154-160. Epub 2016 Sep 9.

Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1159/000449374DOI Listing
September 2017

Primary familial brain calcifications linked with a novel SLC20A2 gene mutation in a Chinese family.

J Neurogenet 2017 09 13;31(3):149-152. Epub 2017 Jun 13.

a Department of Neurology , Xuanwu Hospital of Capital Medical University , Beijing , China.

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http://dx.doi.org/10.1080/01677063.2017.1336235DOI Listing
September 2017

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding.

Cell Res 2017 09 7;27(9):1178-1181. Epub 2017 Jul 7.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/cr.2017.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587854PMC
September 2017

Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice.

J Neural Transm (Vienna) 2017 04 30;124(4):441-453. Epub 2016 Nov 30.

Key Laboratory of Neural Regeneration and Repair, Department of Neurobiology, Capital Medical University, 10 Xi Tou Tiao, You Anmen, Beijing, 100069, China.

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http://dx.doi.org/10.1007/s00702-016-1654-yDOI Listing
April 2017

The cerebellum in dual-task performance in Parkinson's disease.

Sci Rep 2017 03 30;7:45662. Epub 2017 Mar 30.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1038/srep45662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372469PMC
March 2017

MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.

Neurosci Bull 2017 Feb 3;33(1):17-27. Epub 2016 Oct 3.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s12264-016-0069-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567540PMC
February 2017

The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II).

BMC Geriatr 2017 02 8;17(1):47. Epub 2017 Feb 8.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District, 100053, China.

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http://dx.doi.org/10.1186/s12877-017-0439-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299771PMC
February 2017

The underlying mechanism of prodromal PD: insights from the parasympathetic nervous system and the olfactory system.

Transl Neurodegener 2017 20;6. Epub 2017 Feb 20.

Pacific Parkinson's Research Centre, Division of Neurology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia and Vancouver Coastal Health, Vancouver, V6T 1Z3 BC Canada.

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http://dx.doi.org/10.1186/s40035-017-0074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319081PMC
February 2017

Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease.

CNS Neurosci Ther 2017 Jan 24;23(1):76-86. Epub 2016 Sep 24.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/cns.12634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492721PMC
January 2017

Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.

Neurosci Lett 2017 01 24;637:182-187. Epub 2016 Nov 24.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China; Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing 100053, China; Beijing Key Laboratory for Parkinson's Disease, Beijing 100053, China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2016.11.013DOI Listing
January 2017

Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant.

Neurosci Bull 2016 Dec 3;32(6):572-576. Epub 2016 Oct 3.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.

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http://dx.doi.org/10.1007/s12264-016-0070-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567486PMC
December 2016

Association between common genetic risk variants and depression in Parkinson's disease: A dPD study in Chinese.

Parkinsonism Relat Disord 2016 12 29;33:122-126. Epub 2016 Sep 29.

Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China; Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China; Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing, China; Key Laboratory on Parkinson's Disease of Beijing, Beijing, China; Beijing Institute for Brain Disorders Parkinson's Disease Center, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.09.029DOI Listing
December 2016

A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain.

Biosens Bioelectron 2016 Nov 27;85:53-61. Epub 2016 Apr 27.

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Science, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 10090, China. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2016.04.087DOI Listing
November 2016

Excessive Iron and α-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.

J Geriatr Psychiatry Neurol 2016 07 2;29(4):187-94. Epub 2016 Mar 2.

Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing, China Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China Beijing Key Laboratory on Parkinson's Disease, Beijing, China

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http://dx.doi.org/10.1177/0891988716632918DOI Listing
July 2016

Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD.

PLoS One 2015 2;10(10):e0138997. Epub 2015 Oct 2.

Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China; Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592206PMC
June 2016

Post-translational modifications of α-synuclein contribute to neurodegeneration in the colon of elderly individuals.

Mol Med Rep 2016 Jun 22;13(6):5077-83. Epub 2016 Apr 22.

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China.

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http://dx.doi.org/10.3892/mmr.2016.5166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878562PMC
June 2016

Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II.

J Am Geriatr Soc 2016 06;64(6):1281-6

Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/jgs.14135DOI Listing
June 2016

Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

PLoS One 2015 29;10(7):e0134291. Epub 2015 Jul 29.

Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134291PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519305PMC
May 2016

Functional Connectivity of Vim Nucleus in Tremor- and Akinetic-/Rigid-Dominant Parkinson's Disease.

CNS Neurosci Ther 2016 May 5;22(5):378-86. Epub 2016 Feb 5.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/cns.12512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492863PMC
May 2016

Frailty: An Emerging Public Health Priority.

J Am Med Dir Assoc 2016 Mar 21;17(3):188-92. Epub 2016 Jan 21.

Gérontopôle, University Hospital of Toulouse, Toulouse, France; INSERM UMR1027, University of Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2015.12.016DOI Listing
March 2016

Neural correlates underlying micrographia in Parkinson's disease.

Brain 2016 Jan 2;139(Pt 1):144-60. Epub 2015 Nov 2.

1 Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China 2 Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Centre of Beijing Institute for Brain Disorders, Beijing, China.

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http://brain.oxfordjournals.org/content/brain/early/2015/11/
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http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
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http://dx.doi.org/10.1093/brain/awv319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719707PMC
January 2016

Parkinson's disease-related spatial covariance pattern identified with resting-state functional MRI.

J Cereb Blood Flow Metab 2015 Nov 3;35(11):1764-70. Epub 2015 Jun 3.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1038/jcbfm.2015.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635231PMC
November 2015

Motor automaticity in Parkinson's disease.

Neurobiol Dis 2015 Oct 21;82:226-234. Epub 2015 Jun 21.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.

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http://dx.doi.org/10.1016/j.nbd.2015.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565272PMC
October 2015

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

Sci Rep 2015 Oct 28;5:15891. Epub 2015 Oct 28.

CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, P.R. China.

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http://dx.doi.org/10.1038/srep15891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623766PMC
October 2015

Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains.

Neurobiol Aging 2015 Sep 11;36(9):2649-59. Epub 2015 Jun 11.

Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory for Parkinson's Disease, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.004DOI Listing
September 2015

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.

Authors:
Shengli Xu Piu Chan

Biomolecules 2015 Jun 5;5(2):1122-42. Epub 2015 Jun 5.

Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, No.45 changchun St., Xicheng District, Beijing 100053, China.

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http://dx.doi.org/10.3390/biom5021122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496713PMC
June 2015

Lateralization of brain activity pattern during unilateral movement in Parkinson's disease.

Hum Brain Mapp 2015 May 19;36(5):1878-91. Epub 2015 Jan 19.

Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.

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http://dx.doi.org/10.1002/hbm.22743DOI Listing
May 2015

Heterogeneity among patients with Parkinson's disease: cluster analysis and genetic association.

J Neurol Sci 2015 Apr 21;351(1-2):41-45. Epub 2015 Feb 21.

Center for Neurodegenerative disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #6 Tian Tan Xi Li Street, Beijing 100050, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, #10 You'an Men Wai Xi Tou Tiao, Beijing 100069, China; China National Clinical Research Center for Neurological Diseases, #6 Tian Tan Xi Li Street, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2015.02.029DOI Listing
April 2015

Parkinson disease with REM sleep behavior disorder: features, α-synuclein, and inflammation.

Neurology 2015 Mar 6;84(9):888-94. Epub 2015 Feb 6.

From the Departments of Neurology (Y.H., S.-Y.Y., L.-J.Z., C.-J.C., F.W., Z.-J.C., Y.D., T.-H.L., W.Z.) and Geriatrics (S.-Y.Y., W.Z.), and Core Laboratory for Clinical Medical Research (Y.-J.W.), Beijing Tiantan Hospital, Capital Medical University, Beijing; China National Clinical Research Center for Neurological Diseases (W.Z., P.C., S.-D.C., X.-M.W.), Beijing; Center of Parkinson's Disease (W.Z., P.C., S.-D.C., X.-M.W.), Beijing Institute for Brain Disorders; Beijing Key Laboratory on Parkinson Disease (W.Z., P.C., S.-D.C., X.-M.W.); Department of Neurology and Neurobiology (P.C.), Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing; Department of Neurology (S.-D.C.), Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai; and Department of Physiology (X.-M.W.), Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1212/WNL.0000000000001308DOI Listing
March 2015

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.

Sci Rep 2015 Mar 18;5:9232. Epub 2015 Mar 18.

1] Sanofi-Xuanwu Joint Lab for Regenerative Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [2] China R&D Center, Sanofi, Beijing 100022, China.

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http://dx.doi.org/10.1038/srep09232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363833PMC
March 2015