Pitter F Huesgen

Pitter F Huesgen

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Pitter F Huesgen

Pitter F Huesgen

Publications by authors named "Pitter F Huesgen"

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Photoprotective Acclimation of the Leaf Proteome to Fluctuating Light.

Front Genet 2020 5;11:154. Epub 2020 Mar 5.

ZEA-3 Analytics, Forschungszentrum Jülich, Jülich, Germany.

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http://dx.doi.org/10.3389/fgene.2020.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066320PMC
March 2020

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease.

Anal Chem 2020 Feb 31;92(4):2961-2971. Epub 2020 Jan 31.

Central Institute for Engineering, Electronics and Analytics, ZEA-3 , Forschungszentrum Jülich , 52428 Jülich , Germany.

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http://dx.doi.org/10.1021/acs.analchem.9b03604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075662PMC
February 2020

Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins.

Biochim Biophys Acta Proteins Proteom 2019 12 20;1867(12):140138. Epub 2018 Sep 20.

Forschungszentrum Jülich, Central Institute for Engineering, Electronics and Analytics, ZEA-3 Analytics Wilhelm-Johnen-Str, Jülich 52425, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2018.09.004DOI Listing
December 2019

Sensitive Determination of Proteolytic Proteoforms in Limited Microscale Proteome Samples.

Mol Cell Proteomics 2019 11 30;18(11):2335-2347. Epub 2019 Aug 30.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1074/mcp.TIR119.001560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823850PMC
November 2019

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.

J Exp Bot 2019 Apr;70(7):2157-2171

Institute for Interdisciplinary Research, University of Coimbra, Portugal.

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http://dx.doi.org/10.1093/jxb/erz059DOI Listing
April 2019

New beginnings and new ends: methods for large-scale characterization of protein termini and their use in plant biology.

J Exp Bot 2019 Apr;70(7):2021-2038

Forschungszentrum Jülich, Central Institute for Engineering, Electronics and Analytics, ZEA-3 Analytics, Jülich, Germany.

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http://dx.doi.org/10.1093/jxb/erz104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460961PMC
April 2019

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

J Thromb Haemost 2019 03 13;17(3):470-481. Epub 2019 Feb 13.

Department of Biosciences, University of Salzburg, Salzburg, Austria.

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http://dx.doi.org/10.1111/jth.14384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850207PMC
March 2019

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Kidney Int 2019 02 3;95(2):333-349. Epub 2018 Dec 3.

Department II of Internal Medicine, University of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.037DOI Listing
February 2019

The podocyte protease web: uncovering the gatekeepers of glomerular disease.

Am J Physiol Renal Physiol 2018 12 19;315(6):F1812-F1816. Epub 2018 Sep 19.

Division of Graduate Medical Sciences, Boston University School of Medicine , Boston, Massachusetts.

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https://www.physiology.org/doi/10.1152/ajprenal.00380.2018
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http://dx.doi.org/10.1152/ajprenal.00380.2018DOI Listing
December 2018

Dual function of a secreted fungalysin metalloprotease in Ustilago maydis.

New Phytol 2018 10 19;220(1):249-261. Epub 2018 Jun 19.

Botanical Institute and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, BioCenter, Zuelpicher Str. 47a, 50674, Cologne, Germany.

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http://dx.doi.org/10.1111/nph.15265DOI Listing
October 2018

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

Methods Mol Biol 2017 ;1574:35-50

Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Wilhelm-Johnen-Str, 52425, Jülich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6850-3_4DOI Listing
February 2018

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.

Mol Cell Proteomics 2016 07 27;15(7):2515-24. Epub 2016 Apr 27.

From the ‡Institute of Molecular Medicine and Cell Research, ‡‡‡BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany; §§§German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

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http://www.mcponline.org/content/early/2016/04/27/mcp.O115.0
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http://www.mcponline.org/lookup/doi/10.1074/mcp.O115.056671
Publisher Site
http://dx.doi.org/10.1074/mcp.O115.056671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937521PMC
July 2016

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Data Brief 2016 Jun 22;7:299-310. Epub 2016 Feb 22.

Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.dib.2016.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777984PMC
June 2016

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Matrix Biol 2016 Jan 25;49:37-60. Epub 2015 Sep 25.

Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.09.003DOI Listing
January 2016

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Nat Methods 2015 Jan 24;12(1):55-8. Epub 2014 Nov 24.

1] Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada. [2] Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. [3] Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nmeth.3177DOI Listing
January 2015

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

J Proteomics 2015 Jan 14;113:260-7. Epub 2014 Oct 14.

Centre for Blood Research, University of British Columbia, Vancouver, Canada; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.10.002DOI Listing
January 2015

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

Proteomics Clin Appl 2014 Jun 27;8(5-6):338-50. Epub 2014 Mar 27.

Centre for Blood Research, University of British Columbia, Vancouver, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1002/prca.201300104DOI Listing
June 2014

Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids.

PLoS One 2013 16;8(9):e74483. Epub 2013 Sep 16.

Centre for Blood Research and Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada ; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074483PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774753PMC
May 2014

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.

J Proteomics 2014 Apr 11;100:102-14. Epub 2013 Oct 11.

Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2013.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985423PMC
April 2014

Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome.

J Proteome Res 2014 Apr 10;13(4):2028-44. Epub 2014 Mar 10.

Centre for Blood Research, University of British Columbia , 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1021/pr401191wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979129PMC
April 2014

Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system.

J Biol Chem 2013 Jun 25;288(24):17782-90. Epub 2013 Apr 25.

Department of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1074/jbc.M113.462036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682577PMC
June 2013

N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification.

Physiol Plant 2012 May 7;145(1):5-17. Epub 2011 Dec 7.

Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1111/j.1399-3054.2011.01536.xDOI Listing
May 2012

The family of Deg/HtrA proteases in plants.

BMC Plant Biol 2012 Apr 20;12:52. Epub 2012 Apr 20.

Department of Plant Physiology and Biochemistry, University of Konstanz, Universitätsstr, 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1186/1471-2229-12-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473262PMC
April 2012

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis.

Methods Mol Biol 2011 ;781:59-69

Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-276-2_4DOI Listing
January 2012

TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D351-61. Epub 2011 Nov 18.

Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244998PMC
January 2012

Development of soluble ester-linked aldehyde polymers for proteomics.

Anal Chem 2011 Sep 11;83(17):6500-10. Epub 2011 Aug 11.

Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1021/ac200419pDOI Listing
September 2011

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

Nat Protoc 2011 Jan 6;6(1):111-20. Epub 2011 Jan 6.

Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nprot.2010.178DOI Listing
January 2011

Proteome-wide analysis of protein carboxy termini: C terminomics.

Nat Methods 2010 Jul 6;7(7):508-11. Epub 2010 Jun 6.

Department of Biochemistry and Molecular Biology, University of British Columbia, Centre for Blood Research, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nmeth.1467DOI Listing
July 2010

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria.

Res Microbiol 2009 Nov 2;160(9):726-32. Epub 2009 Sep 2.

Department of Plant Physiology and Biochemistry, University of Konstanz, Universitätsstrasse 10, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.resmic.2009.08.005DOI Listing
November 2009

The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis.

Plant Physiol 2008 Dec 24;148(4):1847-56. Epub 2008 Oct 24.

Department of Physiology and Plant Biochemistry, University of Konstanz, DE-78457 Konstanz, Germany.

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http://dx.doi.org/10.1104/pp.108.125377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593680PMC
December 2008

The serine protease HhoA from Synechocystis sp. strain PCC 6803: substrate specificity and formation of a hexameric complex are regulated by the PDZ domain.

J Bacteriol 2007 Sep 6;189(18):6611-8. Epub 2007 Jul 6.

Department of Physiology and Plant Biochemistry, University of Konstanz, Universitätsstrasse 10, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1128/JB.00883-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045181PMC
September 2007

Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants.

Proc Natl Acad Sci U S A 2007 Jul 25;104(27):11501-6. Epub 2007 Jun 25.

Lehrstuhl für Botanik, Technische Universität München, Wissenschaftszentrum Weihenstephan, D-85350 Freising, Germany.

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http://dx.doi.org/10.1073/pnas.0704733104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040927PMC
July 2007

Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease.

FEBS Lett 2006 Dec 4;580(30):6929-32. Epub 2006 Dec 4.

Department of Biology, University of Konstanz, Universitätsstrasse 10, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.febslet.2006.11.058DOI Listing
December 2006