Publications by authors named "Pipsa Saharinen"

46Publications

Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify -Mutant Lung Cancers.

Mol Cancer Ther 2019 10 18;18(10):1863-1874. Epub 2019 Jul 18.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-18-0573DOI Listing
October 2019

Targeting β1-integrin inhibits vascular leakage in endotoxemia.

Proc Natl Acad Sci U S A 2018 07 25;115(28):E6467-E6476. Epub 2018 Jun 25.

Translational Cancer Biology Program, Research Programs Unit, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1722317115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048499PMC
July 2018

SnapShot: Angiopoietins and Their Functions.

Cell 2017 Oct;171(3):724-724.e1

University of Helsinki and Wihuri Research Institute, 00290 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.10.009DOI Listing
October 2017

Therapeutic targeting of the angiopoietin-TIE pathway.

Nat Rev Drug Discov 2017 Sep 19;16(9):635-661. Epub 2017 May 19.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2016.278DOI Listing
September 2017

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.

Proc Natl Acad Sci U S A 2017 04 10;114(17):4376-4381. Epub 2017 Apr 10.

Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1616166114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410806PMC
April 2017

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.

Clin Sci (Lond) 2017 01;131(1):87-103

Translational Cancer Biology Program, Research Programs Unit, University of Helsinki, and Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, P.O.B. 63, FI-00014 University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS20160129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146956PMC
January 2017

Novel Angiogenesis Markers as Long-Term Prognostic Factors in Patients With Renal Cell Cancer.

Clin Genitourin Cancer 2017 02 21;15(1):e15-e24. Epub 2016 Jul 21.

University of Tampere, School of Medicine, Tampere, Finland; Department of Oncology, Tampere University Hospital, Tampere, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clgc.2016.07.008DOI Listing
February 2017

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Blood 2016 08 24;128(5):710-20. Epub 2016 Jun 24.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-12-687970DOI Listing
August 2016

Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion.

Transpl Immunol 2016 07 4;37:40-45. Epub 2016 May 4.

Transplantation Laboratory, University of Helsinki and Cardiac Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trim.2016.05.001DOI Listing
July 2016

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma.

PLoS One 2016 21;11(4):e0153745. Epub 2016 Apr 21.

Translational Cancer Biology Program, Research Programs Unit, and Department of Virology, Haartman Institute, Biomedicum Helsinki, Haartmaninkatu 8, P.O.B. 63, FI-00014, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839598PMC
September 2016

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption.

EMBO Mol Med 2015 Nov;7(11):1418-25

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki University of Helsinki, Helsinki, Finland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201505731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644375PMC
November 2015

Blocking integrin inactivation as an anti-angiogenic therapy.

EMBO J 2015 May 31;34(10):1293-5. Epub 2015 Mar 31.

Department of Food and Biochemistry, Turku Centre for Biotechnology University of Turku, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201591504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491991PMC
May 2015

Endothelial destabilization by angiopoietin-2 via integrin β1 activation.

Nat Commun 2015 Jan 30;6:5962. Epub 2015 Jan 30.

Wihuri Research Institute and Research Programs Unit, Translational Cancer Biology Program and Department of Virology, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, PO Box 63, Helsinki FI-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316742PMC
January 2015

Receptor tyrosine kinase-mediated angiogenesis.

Cold Spring Harb Perspect Biol 2013 Sep 1;5(9). Epub 2013 Sep 1.

Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FIN-00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a009183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753715PMC
September 2013

Angiopoietin signaling in the vasculature.

Exp Cell Res 2013 May 13;319(9):1271-80. Epub 2013 Mar 13.

Oulu Center for Cell-Matrix Research, Biocenter Oulu, and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2013.03.011DOI Listing
May 2013

Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.

J Cell Sci 2012 May 22;125(Pt 9):2212-23. Epub 2012 Feb 22.

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.

View Article

Download full-text PDF

Source
http://jcs.biologists.org/cgi/doi/10.1242/jcs.098020
Publisher Site
http://dx.doi.org/10.1242/jcs.098020DOI Listing
May 2012

The yin, the yang, and the angiopoietin-1.

J Clin Invest 2011 Jun 23;121(6):2157-9. Epub 2011 May 23.

Molecular/Cancer Biology Program and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI58196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104784PMC
June 2011

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis.

Trends Mol Med 2011 Jul 12;17(7):347-62. Epub 2011 Apr 12.

Molecular/Cancer Biology, Research Programs Unit, Biomedicum Helsinki, P.O.B. 63, (Haartmaninkatu 8), FIN-00014, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2011.01.015DOI Listing
July 2011

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.

Dis Model Mech 2011 Jan 2;4(1):57-66. Epub 2010 Nov 2.

Hubrecht Institute-KNAW and University Medical Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.005033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014345PMC
January 2011

How do angiopoietins Tie in with vascular endothelial growth factors?

Curr Opin Hematol 2010 May;17(3):198-205

Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0b013e3283386673DOI Listing
May 2010

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.

Arterioscler Thromb Vasc Biol 2010 Feb 12;30(2):207-9. Epub 2009 Nov 12.

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.109.196618DOI Listing
February 2010

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.

Nat Cell Biol 2008 May 20;10(5):527-37. Epub 2008 Apr 20.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O.B. 63, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb1715DOI Listing
May 2008

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

Mol Cell Biol 2006 Sep;26(17):6381-94

Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA.

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.00570-06
Publisher Site
http://dx.doi.org/10.1128/MCB.00570-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592834PMC
September 2006

Signaling and functions of angiopoietin-1 in vascular protection.

Circ Res 2006 Apr;98(8):1014-23

Department of Cardiovascular Sciences, University of Leicester, RKCSB, PO Box 65, Leicester, LE2 7LX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.RES.0000218275.54089.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270395PMC
April 2006

The Janus kinases (Jaks).

Genome Biol 2004 30;5(12):253. Epub 2004 Nov 30.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gb-2004-5-12-253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545791PMC
October 2005

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

Trends Immunol 2004 Jul;25(7):387-95

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, P.O.B. 63 (Haartmaninkatu 8), 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2004.05.003DOI Listing
July 2004

Molecular regulation of lymphangiogenesis.

Ann N Y Acad Sci 2004 Apr;1014:76-87

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1294.008DOI Listing
April 2004

Double target for tumor mass destruction.

J Clin Invest 2003 May;111(9):1277-80

Molecular/Cancer Biology Laboratory, Haartman Institute, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI18539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154456PMC
May 2003

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.

Mol Biol Cell 2003 Apr;14(4):1448-59

Haartman Institute, Department of Virology, University of Helsinki, Helsinki FIN-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e02-06-0342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153113PMC
April 2003

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.

J Biol Chem 2002 Dec 25;277(49):47954-63. Epub 2002 Sep 25.

Haartman Institute, Department of Virology, Biomedicum Helsinki, Programme for Developmental and Reproductive Biology, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M205156200DOI Listing
December 2002

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.

Biochem Biophys Res Commun 2002 Aug;296(1):139-44

Department of Medical Nutrition, Karolinska Institutet, NOVUM, S-141 86, Hudddinge, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0006-291x(02)00847-1DOI Listing
August 2002