Piotr Sicinski

Piotr Sicinski

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Piotr Sicinski

Publications by authors named "Piotr Sicinski"

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The cell cycle in stem cell proliferation, pluripotency and differentiation.

Nat Cell Biol 2019 Sep 2;21(9):1060-1067. Epub 2019 Sep 2.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-019-0384-4DOI Listing
September 2019

Identification of cell cycle-targeting microRNAs through genome-wide screens.

Cell Cycle 2017 14;16(23):2241-2248. Epub 2017 Nov 14.

a Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1380132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788471PMC
July 2019

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Cancer Cell 2018 12 21;34(6):939-953.e9. Epub 2018 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310147PMC
December 2018

Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.

Oncogene 2018 06 19;37(25):3329-3339. Epub 2018 Mar 19.

Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1038/s41388-018-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388396PMC
June 2018

p600 Plays Essential Roles in Fetal Development.

PLoS One 2013 18;8(6):e66269. Epub 2013 Jun 18.

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; Translational Research Unit and Department of Molecular Pathology, Tokyo Medical University, Shinjuku, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066269PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688873PMC
October 2017

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.

J Cell Biol 2017 10 17;216(10):3133-3143. Epub 2017 Aug 17.

Development and Stem Cell Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1083/jcb.201607111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626527PMC
October 2017

Cell cycle proteins as promising targets in cancer therapy.

Nat Rev Cancer 2017 01;17(2):93-115

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc.2016.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345933PMC
January 2017

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

PLoS Genet 2016 Nov 9;12(11):e1006429. Epub 2016 Nov 9.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102403PMC
November 2016

E-type cyclins modulate telomere integrity in mammalian male meiosis.

Chromosoma 2016 Jun 28;125(2):253-64. Epub 2015 Dec 28.

Department of Genetics & Development, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s00412-015-0564-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833587PMC
June 2016

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Mol Cell 2016 06 26;62(6):929-942. Epub 2016 May 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912424PMC
June 2016

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.

Nat Rev Mol Cell Biol 2016 05 1;17(5):280-92. Epub 2016 Apr 1.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrm.2016.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841706PMC
May 2016

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.

Cancer Cell 2016 Mar;29(3):255-269

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794996PMC
March 2016

Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α.

Diabetes 2014 Oct 19;63(10):3266-78. Epub 2014 Jun 19.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD Department of Pathology, Stony Brook School of Medicine, Stony Brook, NY

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http://dx.doi.org/10.2337/db13-1283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392904PMC
October 2014

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

Dev Cell 2014 Aug 31;30(3):255-67. Epub 2014 Jul 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134362PMC
August 2014

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

Mol Cell 2014 Jun 22;54(6):932-45. Epub 2014 May 22.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118046PMC
June 2014

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Nature 2014 Jun 25;510(7506):547-51. Epub 2014 May 25.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076706PMC
June 2014

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.

Elife 2014 Jun 4;3. Epub 2014 Jun 4.

Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, United States.

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http://dx.doi.org/10.7554/eLife.02872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076869PMC
June 2014

Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory.

J Neurosci 2014 Jan;34(3):804-16

Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom, Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, and Innovative Medicines, AstraZeneca, Mereside, Alderley Park, Cheshire SK10 4TG, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.3320-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891960PMC
January 2014

The kinase-independent, second life of CDK6 in transcription.

Cancer Cell 2013 Aug;24(2):141-3

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809765PMC
August 2013

Differences in regulation and function of E-cyclins in human cancer cells.

Cell Cycle 2013 Apr 2;12(8):1165. Epub 2013 Apr 2.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.4161/cc.24487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674081PMC
April 2013

Proteomic identification of a direct role for cyclin d1 in DNA damage repair.

Cancer Res 2012 Sep 22;72(17):4289-93. Epub 2012 Aug 22.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432743PMC
September 2012

Cyclins A and E trigger DNA damage.

Cell Cycle 2010 Apr 1;9(7):1231-2. Epub 2010 Apr 1.

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http://dx.doi.org/10.4161/cc.9.7.11313DOI Listing
April 2010

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.

Neural Dev 2009 May 5;4:15. Epub 2009 May 5.

Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1186/1749-8104-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694796PMC
May 2009

CDK4 activity in mouse embryos expressing a single D-type cyclin.

Int J Dev Biol 2008 ;52(2-3):299-305

Department of Embryology, University of Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.1387/ijdb.072336mcDOI Listing
June 2008

The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.

Cancer Res 2007 Aug;67(16):7613-20

Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1207DOI Listing
August 2007

Kinase-independent function of cyclin E.

Mol Cell 2007 Jan;25(1):127-39

Department of Cancer Biology, Dana-Farber Cancer Institute, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.11.029DOI Listing
January 2007

Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human.

Cell Cycle 2006 Sep 15;5(18):2110-4. Epub 2006 Sep 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cc.5.18.3218DOI Listing
September 2006

A unique function for cyclin D3 in early B cell development.

Nat Immunol 2006 May 2;7(5):489-97. Epub 2006 Apr 2.

Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ni1324DOI Listing
May 2006

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.

Cancer Cell 2006 Jan;9(1):13-22

Molecular Oncology Research Institute and Department of Radiation Oncology, Tufts-New England Medical Center, 750 Washington Street #5609, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.12.019DOI Listing
January 2006

Requirement for CDK4 kinase function in breast cancer.

Cancer Cell 2006 Jan;9(1):23-32

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.12.012DOI Listing
January 2006

Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins.

Oncogene 2005 Oct;24(47):7114-9

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/1208853
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http://dx.doi.org/10.1038/sj.onc.1208853DOI Listing
October 2005

Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.

Mol Cell Biol 2005 May;25(9):3752-62

Division of Endocrinology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.25.9.3752-3762.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084308PMC
May 2005

Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.

Cell Cycle 2005 Mar 18;4(3):388-91. Epub 2005 Mar 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.4161/cc.4.3.1551DOI Listing
March 2005

Genetic replacement of cyclin D1 function in mouse development by cyclin D2.

Mol Cell Biol 2005 Feb;25(3):1081-8

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.25.3.1081-1088.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544006PMC
February 2005

The critical role of cyclin D2 in adult neurogenesis.

J Cell Biol 2004 Oct;167(2):209-13

Department of Molecular and Cellular Neurobiology, Nencki Institute, 02-093 Warsaw, Poland.

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http://dx.doi.org/10.1083/jcb.200404181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172537PMC
October 2004

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.

Mol Cell Biol 2004 Sep;24(17):7538-47

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 27606, USA.

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http://dx.doi.org/10.1128/MCB.24.17.7538-7547.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC506988PMC
September 2004

Mammalian cell cycles without cyclin E-CDK2.

Cell Cycle 2004 Mar 1;3(3):292-5. Epub 2004 Mar 1.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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March 2004

Requirement for cyclin D3 in lymphocyte development and T cell leukemias.

Cancer Cell 2003 Dec;4(6):451-61

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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December 2003

Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice.

Mol Endocrinol 2003 Oct 10;17(10):2053-69. Epub 2003 Jul 10.

Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1210/me.2003-0038DOI Listing
October 2003

Cyclin E ablation in the mouse.

Cell 2003 Aug;114(4):431-43

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00645-7DOI Listing
August 2003

Development of mice expressing a single D-type cyclin.

Genes Dev 2002 Dec;16(24):3277-89

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://genesdev.cshlp.org/content/16/24/3277.full.pdf
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http://www.genesdev.org/cgi/doi/10.1101/gad.1023602
Publisher Site
http://dx.doi.org/10.1101/gad.1023602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187507PMC
December 2002

Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.

Cancer Res 2002 Jan;62(2):535-41

Whitehead Institute, Cambridge, Massachusetts 02142, USA.

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January 2002