Piotr A Mieczkowski

Piotr A Mieczkowski

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Piotr A Mieczkowski

Publications by authors named "Piotr A Mieczkowski"

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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

PLoS Biol 2019 Sep 30;17(9):e3000464. Epub 2019 Sep 30.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786661PMC
September 2019

Corrigendum to "APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast" [DNA Repair 53 (2017) 4-14].

DNA Repair (Amst) 2019 Aug 7;80:94-95. Epub 2019 Jun 7.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.05.006DOI Listing
August 2019

The two-faced nature of BK polyomavirus: lytic infection or non-lytic large-T-positive carcinoma.

J Pathol 2018 Sep 31;246(1):7-11. Epub 2018 Jul 31.

Department of Genetics, The University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1002/path.5127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120561PMC
September 2018

RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.

MBio 2018 07 3;9(4). Epub 2018 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.00823-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030556PMC
July 2018

Whole Genome Sequence Analysis of Mutations Accumulated in Yeast Strains with Defects in the Processing of Okazaki Fragments Indicates Template-Switching Events.

G3 (Bethesda) 2017 11 6;7(11):3775-3787. Epub 2017 Nov 6.

Department of Natural and Life Sciences, The Open University of Israel, 4353701 Ra'anana, Israel

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http://dx.doi.org/10.1534/g3.117.300262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677150PMC
November 2017

Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity.

Genome Res 2017 10 14;27(10):1674-1684. Epub 2017 Sep 14.

School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA.

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http://dx.doi.org/10.1101/gr.225771.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630031PMC
October 2017

APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.

DNA Repair (Amst) 2017 05 21;53:4-14. Epub 2017 Mar 21.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450012PMC
May 2017

Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2016 12 28;113(50):E8114-E8121. Epub 2016 Nov 28.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710;

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http://dx.doi.org/10.1073/pnas.1618129113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167146PMC
December 2016

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

PLoS Genet 2016 10 27;12(10):e1006385. Epub 2016 Oct 27.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, United States Of America.

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http://dx.doi.org/10.1371/journal.pgen.1006385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082821PMC
October 2016

Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath.

PLoS One 2015 17;10(7):e0133014. Epub 2015 Jul 17.

Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, and North Carolina State University, Raleigh, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133014PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505845PMC
May 2016

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.

Cell Rep 2016 Feb 28;14(6):1273-1282. Epub 2016 Jan 28.

School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758883PMC
February 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome.

J Pathol 2015 Nov 19;237(3):379-89. Epub 2015 Aug 19.

Division of Nephropathology, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042064PMC
http://dx.doi.org/10.1002/path.4584DOI Listing
November 2015

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Nat Genet 2015 Sep 10;47(9):1067-72. Epub 2015 Aug 10.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594173PMC
September 2015

Essential role for polymerase specialization in cellular nonhomologous end joining.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):E4537-45. Epub 2015 Aug 3.

Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599;

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http://dx.doi.org/10.1073/pnas.1505805112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547266PMC
August 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.

Nat Struct Mol Biol 2015 Mar 26;22(3):185-91. Epub 2015 Jan 26.

Genome Integrity &Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health (NIH), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/nsmb.2957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351163PMC
March 2015

Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans.

PLoS Genet 2014 Dec 11;10(12):e1004849. Epub 2014 Dec 11.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263396PMC
December 2014

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

Genome Res 2014 Nov 12;24(11):1751-64. Epub 2014 Sep 12.

Laboratory of Molecular Genetics, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA; Laboratory of Structural Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA;

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http://dx.doi.org/10.1101/gr.178335.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216917PMC
November 2014

Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.

PLoS Pathog 2014 Aug 21;10(8):e1004285. Epub 2014 Aug 21.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1004285
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http://dx.doi.org/10.1371/journal.ppat.1004285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140843PMC
August 2014

Break-induced replication is a source of mutation clusters underlying kataegis.

Cell Rep 2014 Jun 29;7(5):1640-1648. Epub 2014 May 29.

Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242-1324, USA; Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202-5132, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274036PMC
June 2014

Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae.

Genetics 2013 Mar 10;193(3):785-801. Epub 2013 Jan 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1534/genetics.112.146522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583998PMC
March 2013

Chromatin architectures at fission yeast transcriptional promoters and replication origins.

Nucleic Acids Res 2012 Aug 9;40(15):7176-89. Epub 2012 May 9.

Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1093/nar/gks351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424540PMC
August 2012

Tup1 stabilizes promoter nucleosome positioning and occupancy at transcriptionally plastic genes.

Nucleic Acids Res 2011 Nov 23;39(20):8803-19. Epub 2011 Jul 23.

Department of Biochemistry and Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, NY 14203, USA.

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http://dx.doi.org/10.1093/nar/gkr557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203618PMC
November 2011

Damage-induced localized hypermutability.

Cell Cycle 2011 Apr 1;10(7):1073-85. Epub 2011 Apr 1.

National Institute of Environmental Health Sciences, Research Triangle Park, NC USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100884PMC
http://dx.doi.org/10.4161/cc.10.7.15319DOI Listing
April 2011

Genome-wide model for the normal eukaryotic DNA replication fork.

Proc Natl Acad Sci U S A 2010 Oct 27;107(41):17674-9. Epub 2010 Sep 27.

Laboratory of Molecular Genetics and Laboratory of Structural Biology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1073/pnas.1010178107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955150PMC
October 2010

Separating DNA with different topologies by atomic force microscopy in comparison with gel electrophoresis.

J Phys Chem B 2010 Sep;114(37):12162-5

School of Chemistry and Chemical Engineering, Southeast University, Jiangning, Nanjing, Jiangsu 211189, People's Republic of China.

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http://pubs.acs.org/doi/abs/10.1021/jp105603k
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http://dx.doi.org/10.1021/jp105603kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963572PMC
September 2010

UVA generates pyrimidine dimers in DNA directly.

Biophys J 2009 Feb;96(3):1151-8

Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/j.bpj.2008.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716568PMC
February 2009

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.

EMBO J 2008 Nov 2;27(21):2896-906. Epub 2008 Oct 2.

School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1038/emboj.2008.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580784PMC
November 2008

Double-strand breaks associated with repetitive DNA can reshape the genome.

Proc Natl Acad Sci U S A 2008 Aug 13;105(33):11845-50. Epub 2008 Aug 13.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0804529105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515620PMC
August 2008

Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.

PLoS Genet 2008 Jun 27;4(6):e1000105. Epub 2008 Jun 27.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430618PMC
June 2008

Nanoscale detection of ionizing radiation damage to DNA by atomic force microscopy.

Small 2008 Feb;4(2):288-94

Center for Biologically Inspired Materials and Material Systems and Department of Mechanical, Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1002/smll.200700527DOI Listing
February 2008

Detecting ultraviolet damage in single DNA molecules by atomic force microscopy.

Biophys J 2007 Sep 4;93(5):1758-67. Epub 2007 May 4.

Center for Biologically Inspired Materials and Material Systems and Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1529/biophysj.107.108209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948057PMC
September 2007

Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2007 Mar 28;104(10):3955-60. Epub 2007 Feb 28.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0700412104
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http://dx.doi.org/10.1073/pnas.0700412104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805699PMC
March 2007

Recombination between retrotransposons as a source of chromosome rearrangements in the yeast Saccharomyces cerevisiae.

DNA Repair (Amst) 2006 Sep 23;5(9-10):1010-20. Epub 2006 Jun 23.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.dnarep.2006.05.027DOI Listing
September 2006

The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks.

Cell 2006 Jun;125(7):1283-96

School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1016/j.cell.2006.04.042DOI Listing
June 2006

Global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae.

Mol Cell Biol 2006 Feb;26(3):1014-27

Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280, USA.

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http://dx.doi.org/10.1128/MCB.26.3.1014-1027.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347019PMC
February 2006

The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae.

Mol Cell 2004 Jul;15(2):221-31

Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69978, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650400335
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http://dx.doi.org/10.1016/j.molcel.2004.06.002DOI Listing
July 2004

Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae.

Proc Natl Acad Sci U S A 2003 Sep 8;100(19):10854-9. Epub 2003 Sep 8.

Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.

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http://dx.doi.org/10.1073/pnas.1934561100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196892PMC
September 2003