Pingsheng Lei

Pingsheng Lei

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Pingsheng Lei

Pingsheng Lei

Publications by authors named "Pingsheng Lei"

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14Publications

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ORP4L Extracts and Presents PIP from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Cell Rep 2019 Feb;26(8):2166-2177.e9

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.082DOI Listing
February 2019

An Approach to Synthesize Chondroitin Sulfate-E (CS-E) Oligosaccharide Precursors.

J Org Chem 2018 Jun 21;83(11):5897-5908. Epub 2018 May 21.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , 100050 , P. R. China.

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http://dx.doi.org/10.1021/acs.joc.8b00157DOI Listing
June 2018

ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

Nat Commun 2016 09 1;7:12702. Epub 2016 Sep 1.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1038/ncomms12702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025801PMC
September 2016

Synthesis and antibacterial activity of a series of novel 9-O-acetyl- 4'-substituted 16-membered macrolides derived from josamycin.

Bioorg Med Chem Lett 2014 Jan 15;24(2):480-4. Epub 2013 Dec 15.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.029DOI Listing
January 2014

Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities.

Bioorg Med Chem Lett 2013 Dec 3;23(23):6274-9. Epub 2013 Oct 3.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2013.09.083DOI Listing
December 2013

Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides.

Eur J Med Chem 2013 Nov 23;69:174-81. Epub 2013 Aug 23.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.023DOI Listing
November 2013

Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides.

Bioorg Med Chem Lett 2012 Dec 23;22(24):7402-5. Epub 2012 Oct 23.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, PR China.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1201354
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http://dx.doi.org/10.1016/j.bmcl.2012.10.064DOI Listing
December 2012

Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities.

Bioorg Med Chem Lett 2011 Jun 13;21(11):3257-60. Epub 2011 Apr 13.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking 100050, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2011.04.030DOI Listing
June 2011

Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.

Bioorg Med Chem Lett 2011 May 23;21(10):2921-4. Epub 2011 Mar 23.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking 100050, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2011.03.065DOI Listing
May 2011

The synthesis of cholestane and furostan saponin analogues and the determination of sapogenin's absolute configuration at C-22.

Steroids 2011 Jan 20;76(1-2):18-27. Epub 2010 Aug 20.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China.

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http://dx.doi.org/10.1016/j.steroids.2010.07.011DOI Listing
January 2011

Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-->4-linked analogue and their antitumor activities.

Bioorg Med Chem Lett 2010 Sep 29;20(18):5439-42. Epub 2010 Jul 29.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Department of Pharmacology, Peking Union Medical College & Chinese Academy of Medical Sciences, Peking 100050, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2010.07.085DOI Listing
September 2010

Synthesis and cytotoxicities of icogenin analogues with disaccharide residues.

Bioorg Med Chem Lett 2009 May 26;19(10):2796-800. Epub 2009 Mar 26.

Ministry of Education, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.092DOI Listing
May 2009

Synthesis and antibacterial activity of derivatives of 6-O-allylic acylides.

Bioorg Med Chem Lett 2007 Jun 6;17(12):3330-4. Epub 2007 Apr 6.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education Institute of Materia Medica, Peking Union Medica College & Chinese Academy of Medical Sciences, Beijing 100050, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2007.03.107DOI Listing
June 2007

Synthesis and antitumor activity of icogenin and its analogue.

Bioorg Med Chem Lett 2006 May 15;16(9):2454-8. Epub 2006 Feb 15.

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0600140
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http://dx.doi.org/10.1016/j.bmcl.2006.01.074DOI Listing
May 2006