Biography

Primary Affiliation: National Cheng Kung University - Tainan , Taiwan

Specialties: cardiovascular medicine

Publications


Cilostazol improves high glucose-induced impaired angiogenesis in human endothelial progenitor cells and vascular endothelial cells as well as enhances vasculoangiogenesis in hyperglycemic mice mediated by the adenosine monophosphate-activated protein kinase pathway.
J Vasc Surg 2016 Apr 13;63(4):1051-62.e3. Epub 2015 Jan 13.
Cardiovascular Research Center, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.


Left ventricular global longitudinal strain is independently associated with mortality in septic shock patients.
Intensive Care Med 2015 Oct 17;41(10):1791-9. Epub 2015 Jul 17.
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Rd. North District, Tainan, 704, Taiwan.

Pharmacologic strategy for one repeated stent thrombosis patient with hyporesponsiveness to standard dual antiplatelet therapy.
J Formos Med Assoc 2015 Oct 5;114(10):1022-4. Epub 2014 May 5.
Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Fetuin-A as a predicator of sarcopenic left ventricular dysfunction.
Sci Rep 2015 Jul 10;5:12078. Epub 2015 Jul 10.
1] Division of Cardiology, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Fetuin A adds prognostic value for cardiovascular outcomes among patients with coronary artery disease with moderate calcification.
Int J Cardiol 2015 Apr 11;185:159-61. Epub 2015 Mar 11.
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.
Sci Rep 2015 Apr 24;5:9937. Epub 2015 Apr 24.
1] School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan [2] Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [3] Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.

Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression.
J Mol Cell Cardiol 2015 Feb 3;79:180-6. Epub 2014 Dec 3.
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Genome Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

2015 guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension.
J Chin Med Assoc 2015 Jan 26;78(1):1-47. Epub 2014 Dec 26.
Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Allergen exposure induces adipose tissue inflammation and insulin resistance.
Int Immunopharmacol 2014 Nov 26;23(1):104-12. Epub 2014 Aug 26.
Department of Environmental and Occupational Health, Out-Patient Building, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70403, Taiwan. Electronic address:

The AMBITIOUS Study Design and Rationale: Ambulatory Blood Pressure in Taiwanese Occupational Healthcare Staff.
Acta Cardiol Sin 2014 Nov;30(6):565-9
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan; ; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.


Trends in the incidence and management of acute myocardial infarction from 1999 to 2008: get with the guidelines performance measures in Taiwan.
J Am Heart Assoc 2014 Aug 11;3(4). Epub 2014 Aug 11.
Department of Internal Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (C.H.L., T.H.C., J.Y.C., P.Y.L., C.C.L., S.H.C., L.M.T., J.H.C., L.J.L., Y.H.L.).

Changes in right ventricular free wall strain in patients with coronary artery disease involving the right coronary artery.
J Am Soc Echocardiogr 2014 Mar 11;27(3):230-8. Epub 2013 Dec 11.
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.


Soluble thrombomodulin is a paracrine anti-apoptotic factor for vascular endothelial protection.
Int J Cardiol 2014 Mar 22;172(2):340-9. Epub 2014 Jan 22.
Department of Internal Medicine, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan; Cardiovascular Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Prevalence and associated factors of sarcopenia and severe sarcopenia in older Taiwanese living in rural community: the Tianliao Old People study 04.
Geriatr Gerontol Int 2014 Feb;14 Suppl 1:69-75
Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Gerontology, National Cheng Kung University Medical College, Tainan, Taiwan.



Smooth muscle Notch1 mediates neointimal formation after vascular injury.
Circulation 2009 May 11;119(20):2686-92. Epub 2009 May 11.
Vascular Medicine Research, Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA 02139, USA.

Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice.
Cardiovasc Res 2009 Apr 3;82(1):161-9. Epub 2009 Feb 3.
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China.



Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
FASEB J 2008 Oct 12;22(10):3561-70. Epub 2008 Jun 12.
Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02139, USA.


Proteomic analysis of pericardial effusion: Characteristics of tuberculosis-related proteins.
Proteomics Clin Appl 2008 Apr 7;2(4):458-66. Epub 2008 Mar 7.
Department of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan; Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Dou-Liou, Taiwan.

Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction.
Atherosclerosis 2007 Nov 28;195(1):199-206. Epub 2006 Nov 28.
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan.

Genotype-phenotype association of matrix metalloproteinase-3 polymorphism and its synergistic effect with smoking on the occurrence of acute coronary syndrome.
Am J Cardiol 2006 Oct 22;98(8):1012-7. Epub 2006 Aug 22.
Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.


Intracardiac thrombosis in multiple chambers and descending aorta manifested as systemic and pulmonary thromboembolism.
Echocardiography 2005 Sep;22(8):671-4
Division of Cardiology, Department of Internal Medicine, National Cheng-Kung University Medical Center, Tainan, Taiwan.




Pitavastatin and Atorvastatin double-blind randomized comPArative study among hiGh-risk patients, including thOse with Type 2 diabetes mellitus, in Taiwan (PAPAGO-T Study).
PLoS One 2013 1;8(10):e76298. Epub 2013 Oct 1.
Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan ; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.

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