Publications by authors named "Ping Xue"

208 Publications

Effect of Material Properties on the Foaming Behaviors of PP-Based Wood Polymer Composites Prepared with the Application of Spherical Cavity Mixer.

Polymers (Basel) 2021 Sep 19;13(18). Epub 2021 Sep 19.

National Special Superfine Powder Engineering Research Center of China, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

For the low weight and high strength, the microcellular extrusion foaming technology was applied in the preparation of polypropylene (PP)-based wood polymer composites, and the spherical cavity mixer was used to construct an experimental platform for the uniform dispersion of wood flour (WF). The effects of PP molecular configuration on the composite properties and cell morphology of samples were also investigated. The experimental results indicated that the application of a spherical cavity mixer with a cavity radius of 5 mm could effectively improve the mixing quality and avoid the agglomeration of WF. In addition, compared with the branched molecule, the linear molecule not only increased the melting temperature by about 10 °C, but also endowed composites with a higher complex viscosity at a shear rate lower than 100 s, which contributed to the cell morphology of more microporous samples.
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http://dx.doi.org/10.3390/polym13183179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472921PMC
September 2021

Fabrication of zirconium-based metal-organic [email protected] trioxide ([email protected]) heterostructure on carbon cloth for efficient photocatalytic removal of tetracycline antibiotic under visible light.

J Colloid Interface Sci 2021 Aug 19;606(Pt 2):1509-1523. Epub 2021 Aug 19.

Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China. Electronic address:

Designing recyclable photocatalysts with high activity and stability has drawn considerable attention in the fields of sewage treatment. Herein, a series of heterojunctions constructed by zirconium-based metal-organic frameworks (UiO-66-NH) and tungsten trioxide (WO) is immobilized on carbon cloth via a facile solvothermal method, resulting in highly recyclable photocatalysts. Multiple characterization techniques, such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy, verify the successful synthesis of UiO-66-NH nanospheres on the surface of needlelike WO modified carbon cloth. Results show that the optimal heterojunction photocatalyst exhibits excellent photocatalytic degradation efficiency for the removal of tetracycline (TC) from water, for which nearly 100% of TC is degraded within 60 min under visible light. Trapping experiments and electron spin resonance (ESR) spectra analyses demonstrate that the superoxide radicals O and photogenerated hole h play a dominant role in the degradation process. Excellent photocatalytic activity is dominantly attributed to the effective separation of photoinduced carriers in this type-Ⅱ heterostructure system. Moreover, the possible photocatalytic oxidation degradation pathway is confirmed by analyzing intermediates using liquid chromatography mass spectrometry (LC-MS). This study offers a highly efficient strategy to design recyclable heterojunction photocatalysts for the degradation of refractory antibiotics in sewage.
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http://dx.doi.org/10.1016/j.jcis.2021.08.108DOI Listing
August 2021

Photosensitizer IR700DX-6T- and IR700DX-mbc94-mediated photodynamic therapy markedly elicits anticancer immune responses during treatment of pancreatic cancer.

Pharmacol Res 2021 Oct 12;172:105811. Epub 2021 Aug 12.

Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

Background/aims: IR700DX-6T and IR700DX-mbc94 are two chemically synthesized photosensitizers (PSs) that target the translocator protein (TSPO) and type 2 cannabinoid receptor (CBR), respectively, for photodynamic therapy (PDT) of cancer. Recently, we found that IR700DX-6T and IR700DX-mbc94 exhibited high selectivity and efficiency in PDT for breast cancer and malignant astrocytoma. Yet, the phototherapeutic effects of the PSs on pancreatic cancer and underlying mechanisms remain unknown. This study investigated the effect of IR700DX-6T- or IR700DX-mbc94-PDT on pancreatic cancer and whether the treatment involves eliciting anticancer immune responses in support of superior therapeutic efficacy.

Methods: Four pancreatic cancer cell lines were used for in vitro studies. C57BL/6 mice bearing pancreatic cancer cell-derived xenografts were generated for in vivo studies regarding the therapeutic effects of IR700DX-6T-PDT and IR700DX-mbc94-PDT on pancreatic cancer. The immunostimulatory or immunosuppressive effects of IR700DX-6T-PDT and IR700DX-mbc94-PDT were examined by detecting CD8 T cells, regulatory T cells (T), and dendritic cells (DCs) using flow cytometry and immunohistochemistry (IHC).

Results: TSPO and CBR were markedly upregulated in pancreatic cancer cells and tissues. Both IR700DX-6T-PDT and IR700DX-mbc94-PDT significantly inhibited pancreatic cancer cell growth in a dose- and time-dependent manner. Notably, assessment of anticancer immune responses revealed that both IR700DX-6T-PDT and IR700DX-mbc94-PDT significantly induced CD8 T cells, promoted maturation of DCs, and suppressed T, with stronger effects exerted by IR700DX-6T-PDT compared to IR700DX-mbc94-PDT.

Conclusions: IR700DX-6T-PDT and IR700DX-mbc94-PDT involves eliciting anticancer immune responses. Our study has also implicated that PDT in combination with immunotherapy holds promise to improve therapeutic efficacy for patients with pancreatic cancer.
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http://dx.doi.org/10.1016/j.phrs.2021.105811DOI Listing
October 2021

Experimental analysis of natural organic matter controls on nitrogen reduction during bank storage.

J Contam Hydrol 2021 10 8;242:103866. Epub 2021 Aug 8.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430078, Hubei, PR China; School of Environmental Studies, China University of Geosciences, Wuhan 430078, Hubei, PR China. Electronic address:

Particulate organic carbon (POC) significantly influences nitrogen processes in riparian zones. However, the role of different types of natural organic matter (e.g., plant leaves and mud deposits) in nitrate reduction during the hydraulically driven mixing between rivers and groundwater within bank storage (BS) is not well known. Here, we used laboratory columns filled with 30 cm of riparian soil and buried with POC of varying quantity and quality (leaf litter, mud deposit, a mixture of both and a sediment control) on the soil surface in the column to investigate the effects of POC addition on nitrate reduction in low-permeable media. Pore waters were collected and measured periodically to compare the physicochemical differences among these treatments over time during scenarios of downward and upward flow. The leaf litter treatment had a larger amount of POC and higher reactivity, driving pore water to be in suboxic conditions with lower Eh and pH values. Nitrate reduction occurred immediately with downward surface water, and NO was removed in the POC buried layer. Due to the low POC content and low reactivity of the carbon source in the mud deposit, denitrification primarily occurred in the deeper sediment during the downwelling stage, as well as when groundwater returned to the POC buried layer with longer travel times. Both POC quantity and POC quality had strong effects on nitrate reduction. Our results suggested that the leaf litter treatment was preferential for nitrate reduction over the mud deposit treatment, with a higher NO reduction rate and less NH accumulation during the complete BS process.
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http://dx.doi.org/10.1016/j.jconhyd.2021.103866DOI Listing
October 2021

Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2.

Cell Death Differ 2021 Jul 22. Epub 2021 Jul 22.

Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Exosomal microRNAs (miRNAs) have been implicated in the development and progression of a variety of tumors; however, whether they contribute to medulloblastoma (MB) tumorigenesis remains to be elucidated. To address this, we first characterized the miRNA profiles of circulating exosomes by miRNA sequencing to identify miRNAs differentially expressed between children with MB and healthy controls. Then, we conducted in vitro and in vivo functional assays with the identified miRNAs and their predicted targets. We found that, compared with healthy controls, 35 miRNAs were upregulated and 5 downregulated in exosomes isolated from the plasma of MB patients. We further found that the expression of miR-101-3p and miR-423-5p was significantly higher in plasma exosomes from MB patients than in healthy controls in an expanded cohort and these exosomal miRNAs could be delivered to tumor cells via exosomes. An in vitro functional analysis of miR-101-3p and miR-423-5p showed that treating MB cells with the corresponding mimics significantly inhibited the proliferation, colony-forming ability, migratory ability, and invasive capacity of tumor cells, and promoted cell apoptosis. Additionally, miR-101-3p and miR-423-5p were found to act as tumor suppressors by directly targeting a common gene, FOXP4, which encodes a transcription factor with a vital role in embryonic development and tumorigenesis. Moreover, miR-101-3p also targeted EZH2, a histone methyltransferase, to reinforce its tumor inhibitory effects. Using a xenograft nude mouse model of MB, we further identified that the overexpression of miR-101-3p and miR-423-5p inhibited tumorigenesis in vivo. Our findings provide novel insights into the functions of exosomal miRNAs in mediating MB progression and suggest a potential therapeutic approach for the treatment of children with MB.
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http://dx.doi.org/10.1038/s41418-021-00838-4DOI Listing
July 2021

pH-responsive black phosphorus quantum dots for tumor-targeted photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 Sep 6;35:102429. Epub 2021 Jul 6.

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China; College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China; Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China. Electronic address:

Black phosphorus quantum dots(BPQDs) have shown a good application prospect in the field of tumor therapy due to their photoelectric effect and good biodegradability. Due to the active endocytosis and fast metabolic efficiency of tumor cells, BPQDs are easy to be absorbed by tumor cells. However, this does not guarantee that BPQDs will be completely targeted to tumor cells, and normal cells will also absorb BPQDs. Because the cell membrane is negatively charged, BPQDs are also negatively charged and are not easily absorbed by cells under the action of electrostatic repulsion. Surface pegylation is the most common modification method of black phosphorus at present. However, surface pegylation can reduce the uptake of BPQDs by tumor cells. Positive PEG is also easy to be recognized and swallowed by the reticuloendothelial system. The inherent instability and poor tumor targeting of BPQDs under physiological conditions limit further research and clinical application. For this purpose, we selected cationic polymer polyethylenimine (PEI) to modify BPQDs and then added RGD peptides targeting tumor cells. An outer layer of negatively charged PEG+DMMA makes the nanosystem more stable . In the acidic environment of the tumor, the PEG layer has a charge reversal, and the positively charged PEI and the RGD polypeptide BPQDs targeted by the tumor cells are released into the tumor cells. It provides a new method for efficiently and accurately transporting BPQDs, a novel photosensitive nanomaterial, into tumor cells for photodynamic therapy.
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http://dx.doi.org/10.1016/j.pdpdt.2021.102429DOI Listing
September 2021

Internet Access and Nutritional Intake: Evidence from Rural China.

Nutrients 2021 Jun 11;13(6). Epub 2021 Jun 11.

Institute of Agricultural Economics and Development, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Over the past 4 decades, China has experienced a nutritional transition and has developed the largest population of internet users. In this study, we evaluated the impacts of internet access on the nutritional intake in Chinese rural residents. An IV-Probit-based propensity score matching method was used to determine the impact of internet access on nutritional intake. The data were collected from 10,042 rural households in six Chinese provinces. The results reveal that rural residents with internet access have significantly higher energy, protein, and fat intake than those without. Chinese rural residents with internet access consumed 1.35% (28.62 kcal), 5.02% (2.61 g), and 4.33% (3.30 g) more energy, protein, and fat, respectively. There was heterogeneity in regard to the intake of energy, protein, and fat among those in different income groups. Moreover, non-staple food consumption is the main channel through which internet access affects nutritional intake. The results demonstrate that the local population uses the internet to improve their nutritional status. Further studies are required to investigate the impact of internet use on food consumed away from home and micronutrient intake.
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http://dx.doi.org/10.3390/nu13062015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230947PMC
June 2021

Photodynamic immunotherapy of cancers based on nanotechnology: recent advances and future challenges.

J Nanobiotechnology 2021 May 29;19(1):160. Epub 2021 May 29.

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, China.

Photodynamic therapy (PDT) is a non-invasive or minimally-invasive treatment which applies photosensitizers (PSs) to create reactive oxygen species (ROS) exposed to light trigger to destroy cancer cells. PDT can activate host anti-tumor immune responses but not powerful enough to kill metastatic tumors. Because of its carrier advantage, imaging, and therapeutic function together with enhanced permeability and retention (EPR) effect, nano-materials have already been used in photo-immunotherapy. Herein, photodynamic immunotherapy (PDIT) based on nanotechnology seems to be a hopeful new form of cancer therapy. In this article, we firstly summarize the recent development in photodynamic immunotherapy based on nanotechnology.
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http://dx.doi.org/10.1186/s12951-021-00903-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164771PMC
May 2021

Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells.

World J Gastroenterol 2021 May;27(18):2141-2159

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Previous reports have suggested that the p38 mitogen-activated protein kinase signaling pathway is involved in the development of severe acute pancreatitis (SAP)-related acute lung injury (ALI). Inhibition of p38 by SB203580 blocked the inflammatory responses in SAP-ALI. However, the precise mechanism associated with p38 is unclear, particularly in pulmonary microvascular endothelial cell (PMVEC) injury.

Aim: To determine its role in the tumor necrosis factor-alpha (TNF-α)-induced inflammation and apoptosis of PMVECs . We then conducted experiments to confirm the effect of SB203580-mediated p38 inhibition on SAP-ALI.

Methods: , PMVEC were transfected with mitogen-activated protein kinase kinase 6 (Glu), which constitutively activates p38, and then stimulated with TNF-α. Flow cytometry and western blotting were performed to detect the cell apoptosis and inflammatory cytokine levels, respectively. , SAP-ALI was induced by 5% sodium taurocholate and three different doses of SB203580 (2.5, 5.0 or 10.0 mg/kg) were intraperitoneally injected prior to SAP induction. SAP-ALI was assessed by performing pulmonary histopathology assays, measuring myeloperoxidase activity, conducting arterial blood gas analyses and measuring TNF-α, interleukin (IL)-1β and IL-6 levels. Lung microvascular permeability was measured by determining bronchoalveolar lavage fluid protein concentration, Evans blue extravasation and ultrastructural changes in PMVECs. The apoptotic death of pulmonary cells was confirmed by performing a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling analysis and examining the Bcl2, Bax, Bim and cle-caspase3 levels. The proteins levels of P-p38, NFκB, IκB, P-signal transducer and activator of transcription-3, nuclear factor erythroid 2-related factor 2, HO-1 and Myd88 were detected in the lungs to further evaluate the potential mechanism underlying the protective effect of SB203580.

Results: , mitogen-activated protein kinase (Glu) transfection resulted in higher apoptotic rates and cytokine (IL-1β and IL-6) levels in TNF-α-treated PMVECs. , SB2035080 attenuated lung histopathological injury, decreased inflammatory activity (TNF-α, IL-1β, IL-6 and myeloperoxidase) and preserved pulmonary function. Furthermore, SB203580 significantly reversed changes in the bronchoalveolar lavage fluid protein concentration, Evans blue accumulation, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cell numbers, apoptosis-related proteins (cle-caspase3, Bim and Bax) and endothelial microstructure. Moreover, SB203580 significantly reduced the pulmonary P-p38, NFκB, P-signal transducer and activator of transcription-3 and Myd88 levels but increased the IκB and HO-1 levels.

Conclusion: p38 inhibition may protect against SAP-ALI by alleviating inflammation and the apoptotic death of PMVECs.
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http://dx.doi.org/10.3748/wjg.v27.i18.2141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117735PMC
May 2021

Additive Manufacturing of Wood Flour/PHA Composites Using Micro-Screw Extrusion: Effect of Device and Process Parameters on Performance.

Polymers (Basel) 2021 Mar 31;13(7). Epub 2021 Mar 31.

Department of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Based on additive manufacturing of wood flour and polyhydroxyalkanoates composites using micro-screw extrusion, device and process parameters were evaluated to achieve a reliable printing. The results show that the anisotropy of samples printed by micro-screw extrusion is less obvious than that of filament extrusion fused deposition modeling. The type of micro-screw, printing speed, layer thickness, and nozzle diameter have significant effects on the performance of printed samples. The linear relationship between the influencing parameters and the screw speed is established, therefore, the performance of printed products can be controlled by the extrusion flow rate related to screw speed.
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http://dx.doi.org/10.3390/polym13071107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037742PMC
March 2021

Digital filtering ghost imaging to remove light disturbances.

Appl Opt 2021 Feb;60(4):809-814

Ghost imaging (GI) can reconstruct the image of an object when the light traveling from the object to the detector is scattered or distorted. It is usually used in complicated environments, where the environmental light may heavily impact measurement. However, the traditional GI algorithm will be seriously affected if the environmental light changes during the measurement. In this paper, we analyze the frequency of environmental light and the light source, and introduce a digital filtering method that can improve the image quality of the traditional GI algorithm. Compared to the traditional GI algorithm, the digital filtering method can obtain an image even if the environmental light changes seriously.
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http://dx.doi.org/10.1364/AO.415507DOI Listing
February 2021

Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas.

Front Cell Dev Biol 2021 18;9:634056. Epub 2021 Feb 18.

Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Medulloblastoma (MB) is the most common malignant pediatric brain tumor, however, the mechanisms underlying tumorigenesis in different MB subgroups remain incompletely understood. Although previous studies of MB predisposition have been conducted in tertiary referral centers primarily in Caucasian cohorts, it is not unclear clear whether there exist population-specific genetic alterations in MBs. In this study, we investigated the contribution of genomic and transcriptomic alterations to the risk of malignant MB in the Chinese population (designated as the Asian cohort). We analyze the genomic and transcriptomic alterations of the Asian MB cohort by using a combination of whole-exome sequencing (WES) and RNA-deep-sequencing. In addition, we integrate publicly available data with the Asian MB cohort and identify a subset of potential MB-driving genes specifically enriched in each of the MB subgroups. We further characterize a newly identified group-3-enriched transcriptional regulator, ZNF124, and demonstrate that ZNF124 is critical for the growth of the most aggressive group-3 MB cells. Together, our analyses indicate conserved yet distinct genetic alterations and gene expression patterns of MBs between different ethnic groups. Our studies further provide an important resource for identifying potential tumor-driving factors in MBs, enhancing our understanding of the disease process for developing ethnically targeted therapies in patients with MB.
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http://dx.doi.org/10.3389/fcell.2021.634056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930499PMC
February 2021

Optimized SEEG-guided radiofrequency thermocoagulation in the treatment of pediatric hypothalamic hamartomas.

Seizure 2021 Mar 10;86:102-108. Epub 2021 Feb 10.

Department of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center (Shanghai), Shanghai, 201102, PR China. Electronic address:

Purpose: This study investigated the role of one-stage stereo-array radiofrequency thermocoagulation based on stereotactic electroencephalography in the treatment of pediatric hypothalamic hamartomas.

Methods: We analyzed the clinical data of 28 patients with hypothalamic hamartoma. A high-density focal stereo-array electrode implantation strategy was adopted. Stereotactic electroencephalography guided bipolar coagulations were performed between two contiguous contacts of the same electrode, or between two adjacent contacts of different electrodes. Patients with hypothalamic hamartoma were divided into two groups based on hamartoma size (maximum diameter < 15 mm vs maximum diameter ≥ 15 mm). Numbers of implanted electrodes and contacts used for thermocoagulation were documented. Seizure outcome was evaluated according to Engel's classification.

Results: Surgical procedures were well tolerated and no repeated surgery was performed. The median number of electrodes implanted in the two groups was significantly different (p =  0.0009), as well as the median number of contacts where radiofrequency thermocoagulation was applied (p =  0.0006). Moreover, the number of implanted electrodes and contacts used for thermocoagulation were positively correlated with the hamartoma volume (Spearman's rho = 0.7074, p<0.0001 and Spearman's rho = 0.7435, p<0.0001, respectively). The overall seizure-free rate was 82.1 %, with 92.9 % of the patients having favorable outcomes for at least 12 months of follow-up. Seizure outcomes between two groups were not statistically significant (p =  0.3138).

Conclusion: One-stage high-density focal stereo-array stereotactic electroencephalography guided radiofrequency thermocoagulation using cross-bonded electrode contacts for ablation range expansion is a safe and effective surgical approach for children with hypothalamic hamartoma.
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http://dx.doi.org/10.1016/j.seizure.2021.01.023DOI Listing
March 2021

Bimetallic oxide MnFeO modified carbon felt anode by drip coating: an effective approach enhancing power generation performance of microbial fuel cell.

Bioprocess Biosyst Eng 2021 Jun 8;44(6):1119-1130. Epub 2021 Feb 8.

National Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan, 750021, People's Republic of China.

The anode electrode of microbial fuel cell (MFC) is the key component to determine its power generation performance because it is the habitat and electron transfer center of the electricity-producing microorganisms. Carbon-based anodes have been confirmed to improve MFC performance. Its large surface area, excellent conductivity and low cost make it very suitable for electrode materials used in MFC. However, the low biocompatibility and instability of common carbon-based materials restrict their practical application in MFC. In this work, a bimetal oxide MnFeO was prepared and used to modify carbon felt anode by a simple drop coating method. The influence of the amount of MnFeO material on the performance of MFC was systematically studied. The results showed that the power density of the carbon felt anode with a MnFeO modified amount of 1 mg/cm increased by 66.9% compared with the unmodified anode. Meanwhile, the MFC cycle using MnFeO modified anode was more stable. After 6 months of long-term operation, the power density reached 3836 mW/m. The anode modified by MnFeO has capacitance characteristics, good biocompatibility and fast electron transmission rate, which significantly improves the power generation performance of MFC. In addition, the use of a simple drop coating method to prepare electrodes can reduce the difficulty of electrode fabrication and the cost of MFC, laying a certain foundation for the industrialization of MFC.
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http://dx.doi.org/10.1007/s00449-021-02511-zDOI Listing
June 2021

Successful Treatment of Corticosteroid-Induced Rosacea-Like Dermatitis with Platelet-Rich Plasma Mesotherapy: Report of Seven Cases.

Dermatol Ther (Heidelb) 2021 Apr 4;11(2):615-623. Epub 2021 Feb 4.

Department of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Introduction: Corticosteroid-induced rosacea-like dermatitis (CIRD) is one of the cutaneous side effects of long and excessive application of topical corticosteroids, resembling rosacea that can present with a series of cutaneous manifestations. Most patients with CIRD undergo a variety of long-term treatments before their symptoms are relieved as there is no accepted standard therapy. We gave each of seven patients two sessions of platelet-rich plasma (PRP) mesotherapy before the routine treatment to restore their skin barrier function, and we were surprised to find that the patients' symptoms and appearance were significantly improved without any further treatments. Here we report this unexpected finding in dealing with CIRD.

Case Presentation: Seven patients, one male and six female, who had history of applying topical corticosteroids on the face for more than 3 months continuously or intermittently for various reasons were diagnosed with CIRD, showing varying degrees of erythema, telangiectasia, and papules, with dry skin, pain, and burning or stinging sensation. We intended to use the restorative effect of PRP to restore the skin barrier function of the patients for further treatment such as tacrolimus ointment, intense pulsed light (IPL), or pulsed dye laser (PDL), so they were treated twice with PRP intradermal injections using a mesogun injector machine. We used the VISIA skin detector to photograph and compare the changes after the treatments. Clinical efficacy was also assessed by the Global Aesthetic Improvement Scale (GAIS). Patients' assessments were recorded using three-point scale questionnaires. After two sessions of PRP treatment, before any further treatment, we were surprised to find that the patients' symptoms had improved significantly, as confirmed by VISIA skin detector and GAIS. All of the patients were satisfied with the outcomes, considering that mesotherapy was not painful and their appearance and symptoms had much improved.

Conclusions: PRP mesotherapy may mitigate sensitivity and inflammation in patients with CIRD by reducing erythema, telangiectasia, and papules. It is worth conducting large randomized controlled trials to verify its safety and efficacy in treating corticosteroid-induced rosacea-like dermatitis and maybe rosacea.
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http://dx.doi.org/10.1007/s13555-021-00492-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019010PMC
April 2021

Assembled Exciton Dynamics in Porphyrin Metal-Organic Framework Nanofilms.

Nano Lett 2021 Jan 6;21(2):1102-1107. Epub 2021 Jan 6.

Laboratory for Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China.

Metal-organic frameworks (MOFs) provide a novel strategy to precisely control the alignment of molecules to enhance exciton diffusion for high-performance organic semiconductors. In this paper, we characterize exciton dynamics in highly ordered and crystalline porphyrin MOF nanofilms by time-resolved photoluminescence and femtosecond-resolved transient absorption spectroscopy. Results suggest that porphyrin MOF nanofilms could be a promising candidate for high-performance organic photovoltaic semiconductors in which the diffusion coefficient and diffusion length of excitons are 9.0 × 10 cm s and 16.6 nm, respectively, comparable with or even beyond that of other excellent organic semiconductors. Moreover, by monitoring real-time exciton dynamics it is revealed that excitons in MOF nanofilms undergo high-efficient intermolecular hopping and multiexciton annihilation due to the short intermolecular distance and aligned molecular orientation in MOF structure, thus providing new insights into the underlying physics of exciton dynamics and many-body interaction in molecular assembled systems.
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http://dx.doi.org/10.1021/acs.nanolett.0c04492DOI Listing
January 2021

High-speed all-optical processing for spectrum.

Opt Express 2021 Jan;29(1):305-314

Data-processing techniques in spectroscopy are fundamental and powerful analytical tools for lots of practical applications. In the age of big data, high-speed data-processing in spectroscopy is in urgent need, especially for the real-time analysis/feedback of data stream of spectroscopy or the capture of non-repetitive/rare phenomena in fast dynamic process. So far, intensive researches focus on high-speed processing of light signal in time/spatial domain but few people find a way to do it in spectral domain. Here, we report an optical computing technology for high-speed optical spectrum processing with features of real time, multiple functions, all-fiber configuration and immunity to electromagnetic interference. The software-controlled system could perform as, but not limited to, the first-order (or arbitrary fractional-order) differentiator/integrator/Hilbert transformer and tunable band-pass filter, respectively, to handle spectral data rapidly. High-speed processing of optical spectrum at a rate of 10,000,000 times per second is demonstrated.
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http://dx.doi.org/10.1364/OE.413628DOI Listing
January 2021

A novel approach to efficient degradation of indole using co-immobilized horseradish peroxidase-syringaldehyde as biocatalyst.

Chemosphere 2021 Jan 23;262:128411. Epub 2020 Sep 23.

State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering, College of Chemistry & Chemical Engineering, Ningxia University, Yinchuan, 750021, PR China. Electronic address:

Biocatalytic degradation technology has received a great deal of attention in water treatment because of its advantages of high efficiency, environmental friendliness, and no secondary pollution. Herein, for the first time, horseradish peroxidase and mediator syringaldehyde were co-immobilized into functionalized calcium alginate composite beads grafted with glycidyl methacrylate and dopamine. The resultant biocatalyst of the co-immobilized horseradish peroxidase-syringaldehyde system has displayed excellent catalytic performance to degrade indole in water. The degradation rate of 100% was achieved in the presence of hydrogen peroxide even if the indole concentration was changing from 25 mg/L to 500 mg/L. If only the free enzyme was used under the identical water treatment conditions, the degradation of indole could hardly be observed even when the concentration of indole is low at 25 mg/L. This was attributed to the effective co-immobilization of the enzyme and the mediator so that the catalytic activity of horseradish peroxidase and the synergistic catalytic action of syringaldehyde could be fully developed. Furthermore, while the spherical catalyst was operated in succession and reused for four cycles in 50 mg/L indole solution, the degradation rate remained 91.8% due to its considerable reusability. This research demonstrated and provided a novel biocatalytic approach to degrade indole in water by the co-immobilized horseradish peroxidase-syringaldehyde system as biocatalyst.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128411DOI Listing
January 2021

Long-term results of ERCP- or PTCS-directed photodynamic therapy for unresectable hilar cholangiocarcinoma.

Surg Endosc 2021 10 26;35(10):5655-5664. Epub 2020 Oct 26.

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou Medical University, #250 East Changgang Road, Guangzhou, 510260, China.

Background: Photodynamic therapy (PDT) can be performed as palliative therapy for cholangiocarcinoma, while there is currently insufficient evidence for the efficacy. The aim of this study was to explore the clinical efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement for unresectable hilar cholangiocarcinoma.

Methods: A retrospective analysis was conducted on 62 patients with unresectable hilar cholangiocarcinoma. Thirty patients received PDT using hematoporphyrin combined with biliary stent placement (PDT+stent group), including 22 receiving ERCP-directed PDT and 8 receiving PTCS-directed PDT. Survival time, quality of life, and postoperative adverse events were compared to 32 patients receiving biliary stent placement alone (Stent-only group).

Results: After 42 months of follow-up, median survival time was significantly longer in the PDT+stent group than the Stent-only group (14.2 vs. 9.8 months, P = 0.003). In the PDT+stent group, the median survival time was longer in the 6 patients with recurrence after surgical resection than the 24 patients without prior surgical resection (20.0 vs. 13.0 months, P = 0.017). The QOL total scores was significantly higher in the PDT+stent group than the Stent-only group at postoperative 6, 9, and 12 months (P<0.05). There was no significant difference in the incidence of postoperative adverse events between the two groups (24 [38.7%] vs. 20 [29.0%], P = 0.239).

Conclusion: ERCP- or PTCS-directed PDT + stent placement can prolong the survival of patients with unresectable hilar cholangiocarcinoma, especially those with recurrence and improve quality of life without increasing adverse events.
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http://dx.doi.org/10.1007/s00464-020-08095-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437910PMC
October 2021

Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis.

Onco Targets Ther 2020 29;13:9643-9655. Epub 2020 Sep 29.

Department of Gynecology, Qingdao Traditional Chinese Medicine Hospital, Qingdao City, Shandong Province 266000, People's Republic of China.

Purpose: Endometrial cancer (EC) is an aggressive tumor in females and the development of EC is considered to regulate by some long non-coding RNAs (lncRNAs). Therefore, this study aimed to investigate the regulatory mechanism of lncRNA LINC01106 on EC.

Methods: The expression of lncRNA LINC01106, miR-449a and MET in EC tissues and cells was detected by qRT-PCR. Through MTT, wound healing and transwell invasion assays, the proliferation, migration and invasion of EC cells were detected, respectively. The xenograft tumor model was constructed in nude mice to confirm the inhibiting effect of LINC01106 knockdown on EC in vivo. The interactions between miR-449a and LINC01106/MET were predicted by Starbase/Targetscan software and verified by the dual-luciferase reporter assay or RNA immunoprecipitation assay. Western blot assay was performed to determine the protein level of MET.

Results: LncRNA LINC01106 expression was highly up-regulated in EC tissues and cells. The proliferation, migration and invasion of EC cells in vitro were inhibited by the transfection of sh-LINC01106. The growth of tumor xenograft was suppressed by injection of sh-LINC01106. MiR-449a was a target of LINC01106and was negatively modulated by LINC01106. MiR-449a overexpression suppressed the proliferation, migration and invasion of EC cells. In addition, MET was identified as a target gene of miR-449a. Both the high expression of miR-449a and low expression of MET reversed the inhibiting effects of LINC01106 knockdown on Ishikawa cells.

Conclusion: Silencing of LINC01106 inhibits the occurrence and development of EC via regulating the miR-449a/MET axis. This study provides a possible therapeutic strategy for EC.
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http://dx.doi.org/10.2147/OTT.S264642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532893PMC
September 2020

Laccase-mediator system assembling co-immobilized onto functionalized calcium alginate beads and its high-efficiency catalytic degradation for acridine.

Colloids Surf B Biointerfaces 2020 Dec 1;196:111348. Epub 2020 Sep 1.

State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering, College of Chemistry & Chemical Engineering, Ningxia University, Yinchuan, 750021, China.

A heterogeneous bead-shaped biocatalyst was prepared by assembling co-immobilization of encapsulating mediator 2,2'-Azino-bis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) into the functionalized calcium alginate composite beads by grafting glycidyl methacrylate and dopamine and then immobilizing laccase covalently onto beads. The enzyme-catalyzed degradation for acridine in water was systematically studied for the first time, and it was found that the co-immobilized laccase-mediator system has excellent capability to degrade acridine in water. Treating 30 mg/L acridine aqueous solution for 8 h with the biocatalyst, the degradation rate of acridine reached 100 %. In contrast, the degradation of acridine by free laccase under the same treatment conditions was low and difficult to observe. Its outstanding catalytic activity could be attributed to the effective assembling co-immobilization of laccase and the mediator so that the catalytic activity of the enzyme and the synergistic promoting action of the mediator have been given full play in the process of acridine degradation. The beaded biocatalyst about 3 mm in diameter could be easily recovered and reused several times without obvious deterioration in catalytic activity. Furthermore, according to the test results of electron paramagnetic resonance and the identified intermediates, the possible biocatalytic mechanism and reaction pathways for acridine degradation have been proposed.
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http://dx.doi.org/10.1016/j.colsurfb.2020.111348DOI Listing
December 2020

Study on Preparation of Ultra-High-Molecular-Weight Polyethylene Pipe of Good Thermal-Mechanical Properties Modified with Organo-Montmorillonite by Screw Extrusion.

Materials (Basel) 2020 Jul 27;13(15). Epub 2020 Jul 27.

School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

The study of processing characteristic and property optimization of ultra-high-molecular-weight polyethylene (UHMWPE) pipe is increasingly performed, mainly focusing on difficulties in the melting process and poor thermal-mechanical properties after forming, which have limited the wider engineering application of UHMWPE pipe. In this study, organo-montmorillonite (OMMT)-modified UHMWPE pipe with good thermal-mechanical properties was prepared by screw extrusion molding. First, high-density polyethylene was subjected to fluidity modification so that the screw extrusion molding of UHMWPE pipe was feasible. Then, OMMT-modified UHMWPE pipes under different addition amounts of OMMT were innovatively prepared by extrusion. Furthermore, the effects of the addition amounts of the compatibilizer HDPE-g-MAH and the silane coupling agent γ-(2,3-epoxy propoxy) propyl trimethoxy silane (KH560) on the thermal properties of OMMT-modified UHMWPE pipe were investigated for the first time. Compared with those of pure UHMWPE pipe, the Vicat softening temperature (from 128 to 135.2 °C), thermal deformation temperature (from 84.4 to 133.1 °C), bending strength (from 27.3 to 39.8 MPa), and tensile strength (from 20.8 to 25.1 MPa) of OMMT-modified UHMWPE pipe were greatly increased. OMMT-modified UHMWPE pipe with good thermal-mechanical properties was able to be prepared by extrusion for the first time. The compatibilizer method of HDPE-g-MAH was slightly more effective than the coupling agent method of KH560.
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http://dx.doi.org/10.3390/ma13153342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435758PMC
July 2020

Adaptive ghost imaging.

Opt Express 2020 Jun;28(12):17232-17240

Traditional ghost imaging applies correlated algorithms to reconstruct the image of an object. However, it fundamentally requires some spatial distributions of the correlated light beam, e.g. random illumination, which hardly exists in reality. Here, different from the localized analysis used in the traditional ghost imaging, a spatial and temporal global analysis of the whole measurements is proposed. Therefore, we demonstrate a new ghost imaging modality, called adaptive ghost imaging (AGI), that utilizes the difference of successive frames as the correlation pattern to generate the image. As a result, AGI can work with any varying illuminations including, but not limited to, random illumination. We believe that AGI will make the ghost imaging easier, more applicable and closer to reality.
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http://dx.doi.org/10.1364/OE.391788DOI Listing
June 2020

Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis.

Cell Death Dis 2020 06 1;11(6):408. Epub 2020 Jun 1.

Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, 200032, Shanghai, China.

Exosomes are an important carrier for cell communication. miRNAs in exosomes are potential biomarkers and therapeutic targets in different types of cancer. However, the role of exosomal miRNAs in medulloblastoma (MB) patients is largely unknown. In this study, we reported that there was a higher level of miR-130b-3p in exosomes derived from MB patient plasma compared with exosomes from healthy control plasma. Exosomes from MB patient plasma could transfer miR-130b-3p to an MB cell line and played suppressor roles for cell proliferation. miR-130b-3p suppressed MB tumorigenesis by targeting a previously unknown target, serine/threonine-protein kinase 1 (SIK1), through the p53 signaling pathways. In addition, we found an unreported role of SIK1 in promoting MB tumor growth and an SIK1 inhibitor could inhibit MB cell proliferation. This research provides new insight into the molecular mechanism of MB and may provide a new therapeutic strategy for MB treatment.
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http://dx.doi.org/10.1038/s41419-020-2621-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264172PMC
June 2020

Application of Robot-Assisted Frameless Stereoelectroencephalography Based on Multimodal Image Guidance in Pediatric Refractory Epilepsy: Experience of a Pediatric Center in a Developing Country.

World Neurosurg 2020 08 8;140:e161-e168. Epub 2020 May 8.

Department of Neurosurgery, Children's Hospital of Fudan University, Shanghai, P.R China. Electronic address:

Objective: To introduce the application of robot-assisted frameless stereoelectroencephalography (SEEG) based on multimodal image fusion technology in pediatric refractory epilepsy in a pediatric center from a developing country.

Methods: We retrospectively evaluated pediatric patients with drug-resistant epilepsy who underwent SEEG monitoring at the Children's Hospital of Fudan University from July 2014 to August 2017. Application of multimodal image fusion technology in SEEG was described in detail. Seizure outcomes were assessed according to the International League Against Epilepsy classification.

Results: A total of 208 patients were initially eligible and underwent a rigorous phase I evaluation. SEEG explorations were performed in 20 patients who entered phase II assessment (11 male and 9 female patients) with a median age of 7.99 ± 4.07 years. In total, 181 electrodes were implanted (9 per implantation), among which 16 implantations were unilateral (6 left and 10 right) and 4 were bilateral. The mean operating time was 3 hours and no obvious hemorrhage occurred. Electrode displacement and pneumocephalus were observed in 1 and 2 patients, respectively. Thirteen and 7 patients underwent tailored resection and radiofrequency thermocoagulation, respectively. Among resection cases, focal cortical dysplasia was the predominant pathologic type. The overall seizure outcome after a mean follow-up of 2.65 years was International League Against Epilepsy class 1 in 13, class 2 in 2, class 3 in 3, class 4 in 1, and class 5 in 1 patient, respectively.

Conclusions: The combination of multimodal image fusion and frameless robot-assisted SEEG is demonstrated to be safe and effective on children with refractory epilepsy in developing countries.
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http://dx.doi.org/10.1016/j.wneu.2020.04.218DOI Listing
August 2020

The disconnection technique with the use of a bronchial blocker for improving nonventilated lung collapse in video-assisted thoracoscopic surgery.

J Thorac Dis 2020 Mar;12(3):876-882

Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Background: One-lung ventilation (OLV) is becoming an essential component of thoracic anesthesia. The two principal devices used for OLV are a double-lumen tube (DLT) and a bronchial blocker (BB). We hypothesized that the use of a BB with the disconnection technique would improve the quality of lung collapse in video-assisted thoracoscopic surgery (VATS).

Methods: Seventy-five patients undergoing scheduled VATS were enrolled in this study and were randomly divided into two groups: a left-sided DLT group (Group D) and a BB with the disconnection technique group (Group B). OLV was initiated when the surgeon performed the skin incision. In Group D, the left channel of the DLT was opened to the air. In Group B, the lung was deflated via the disconnection technique, thus opening the breathing circuit to the air fifteen seconds after opening the pleura. The mean arterial pressure (MAP) and heart rate (HR) during induction; the quality of lung collapse 1 and 10 minutes after pleural opening; the time required for complete lung collapse; the correct placement of the device; and the number of patients suffering from a sore throat after surgery were recorded.

Results: Compared with the use of the DLT, the use of the BB with the disconnection technique was associated with a similar quality of lung collapse, a comparable required time for total lung collapse (P>0.05, respectively), a lower incidence of sore throat both when leaving the PACU and 24 hours after surgery (34.2% 13.5%, 15.8% 5.4%, P<0.05, respectively) and fewer hemodynamic fluctuations after intubation both one and ten minutes after pleural opening.

Conclusions: The use of a BB with the disconnection technique in VATS offers an effective method for improving the quality of lung collapse and reducing postoperative sore throat.
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http://dx.doi.org/10.21037/jtd.2019.12.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139096PMC
March 2020

Chaiqin chengqi decoction alleviates severe acute pancreatitis associated acute kidney injury by inhibiting endoplasmic reticulum stress and subsequent apoptosis.

Biomed Pharmacother 2020 May 27;125:110024. Epub 2020 Feb 27.

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, 37# Guoxue Street, Chengdu 610041, China. Electronic address:

Background: Acute kidney injury (AKI), characterized by an increase of serum creatinine and urea, is a severe complication of severe acute pancreatitis (SAP) with high mortality. Endoplasmic reticulum (ER) stress has been considered as a key pathologic process in AKI. Chaiqin chengqi decoction (CQCQD) is an effective Chinese medicine formula for SAP treatment in China and has been used for many years. Our goal is to explore the role of CQCQD on ER stress of AKI in experimental SAP.

Materials & Methods: SAP was induced in rats by retrograde duct injection of 5% sodium taurocholate (NaTC, 1 ml/kg), sham operation (SO) rats simultaneously received saline infusion. Intraperitoneal injection of 4-PBA (50 mg/kg, once a day for three days before the surgery) or intragastric gavage of CQCQD (1 g/kg, 2 hourly × 3 after disease induction) was used to treat SAP rats. All animals were humanely sacrificed 12 h after disease induction. Histopathology scores of kidney and pancreas; serum biochemical indices and kidney protein levels of ER stress and apoptosis markers were assessed. Tubular epithelial cell line (HK-2) was treated either with TNF-α (10 ng/ml) or IL-6 (10 ng/ml) for 12 h plus either 4-PBA (0.1 M) or CQCQD (1 mg/ml) for in vitro study. Cell viability and markers of ER stress and apoptosis were measured.

Results: Ductal perfusion of NaTC caused significant increases in serum lipase, amylase and pancreatic histopathology (inflammatory cell infiltration, interstitial edema, and acinar cell necrosis). Kidney histopathology (tubular dilation, brush border loss, little tubular necrosis, and cast formation), serum creatine and urea levels were raised when compared with the SO group. Moreover, apoptotic cell death markers (caspase-9, cleaved-caspase-3, and TUNEL) and kidney ER stress proteins (BIP, IRE1-α, XBP1s, and CHOP) were elevated after NaTC administration. 4-PBA and CQCQD significantly alleviated histopathological changes of kidney and pancreas, inflammatory cytokines, biochemical markers of AKI, ER stress proteins and apoptotic cell death markers. They also protected HK-2 cells from injury of TNF-α and IL-6, and alleviated both ER stress and apoptosis proteins in vitro.

Conclusion: CQCQD may alleviate SAP-related AKI by inhibiting ER stress-related apoptosis.
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http://dx.doi.org/10.1016/j.biopha.2020.110024DOI Listing
May 2020

Correction to: Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth.

Mol Cancer 2020 03 14;19(1):59. Epub 2020 Mar 14.

Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, 250# Changgang East Road, Haizhu District, Guangzhou, 510260, People's Republic of China.

Following the publication of article [1], the authors found that the images of Transwell Matrigel invasion (Fig. 7d) are incorrect.
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http://dx.doi.org/10.1186/s12943-020-01177-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071760PMC
March 2020

Hemp-based all-cellulose composites through ionic liquid promoted controllable dissolution and structural control.

Carbohydr Polym 2020 May 17;235:116027. Epub 2020 Feb 17.

College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, 100029 Beijing, China. Electronic address:

All-cellulose composites (ACC) were effectively prepared by a low energy consumption strategy. The ionic liquid of 1-butyl-3-methylimidazolium chloride (BMIMCl) was used to immerse hemp fabric before hot-pressing process at a relative low temperature. The tensile strength and modulus of prepared ACC reached 81.1 MPa and 1.50 GPa, respectively. The dissolution mechanism of ACC by BMIMCl was successfully observed by the cooperation of optical microscope and polarizing microscope. Scanning electron microscope (SEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA) and mechanical testing were carried out to investigate the effect of hot-pressing temperature on the properties of ACC samples. ACC sample exhibited the highest mechanical performance at hot-pressing temperature of 120 °C. This work provided a simple and promising pathway for industrial application of high performance and environmental-friendly all-cellulose composites.
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http://dx.doi.org/10.1016/j.carbpol.2020.116027DOI Listing
May 2020

Speckle reducing OCT using optical chopper.

Opt Express 2020 Feb;28(3):4021-4031

Optical coherence tomography (OCT) has been an important and powerful tool for biological research and clinical applications. However, speckle noise significantly degrades the image quality of OCT and has a negative impact on the clinical diagnosis accuracy. In this paper, we propose a novel speckle noise suppression technique which changes the spatial distribution of sample beam using a special optical chopper. Then a series of OCT images with uncorrelated speckle patterns could be captured and compounded to improve the image quality without degradation of resolution. Typical signal-to-noise ratio improvement of ∼6.4 dB is experimentally achieved in tissue phantom imaging with average number n = 100. Furthermore, compared with conventional OCT, the proposed technique is demonstrated to view finer and clearer biological structures in human skin in vivo, such as sweat glands and blood vessels. The advantages of low cost, simple structure and compact integration will benefit the future design of handheld or endoscopic probe for biomedical imaging in research and clinical applications.
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http://dx.doi.org/10.1364/OE.382369DOI Listing
February 2020
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