Publications by authors named "Pilar Gonzalez"

24 Publications

  • Page 1 of 1

Functional Meat Products as Oxidative Stress Modulators: A Review.

Adv Nutr 2021 Feb 12. Epub 2021 Feb 12.

Nutrition and Food Science Department (Nutrition), Pharmacy School, Complutense University of Madrid, Madrid, Spain.

High meat consumption has been associated with increased oxidative stress mainly due to the generation of oxidized compounds in the body, such as malondialdehyde, 4-hydroxy-nonenal, oxysterols, or protein carbonyls, which can induce oxidative damage. Meat products are excellent matrices for introducing different bioactive compounds, to obtain functional meat products aimed at minimizing the pro-oxidant effects associated with high meat consumption. Therefore, this review aims to summarize the concept and preparation of healthy and functional meat, which could benefit antioxidant status. Likewise, the key strategies regarding meat production and storage as well as ingredients used (e.g., minerals, polyphenols, fatty acids, walnuts) for developing these functional meats are detailed. Although most effort has been made to reduce the oxidation status of meat, newly emerging approaches also aim to improve the oxidation status of consumers of meat products. Thus, we will delve into the relation between functional meats and their health effects on consumers. In this review, animal trials and intervention studies are discussed, ascertaining the extent of functional meat products' properties (e.g., neutralizing reactive oxygen species formation and increasing the antioxidant response). The effects of functional meat products in the frame of diet-gene interactions are analyzed to 1) discover target subjects that would benefit from their consumption, and 2) understand the molecular mechanisms that ensure precision in the prevention and treatment of diseases, where high oxidative stress takes place. Long-term intervention-controlled studies, testing different types and amounts of functional meat, are also necessary to ascertain their positive impact on degenerative diseases.
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http://dx.doi.org/10.1093/advances/nmaa182DOI Listing
February 2021

Coping With Trauma, Celebrating Life: Reinventing Patient And Staff Support During The COVID-19 Pandemic.

Health Aff (Millwood) 2020 Sep 16;39(9):1597-1600. Epub 2020 Jul 16.

Hyung J. Cho is chief value officer, Quality and Safety, NYC Health + Hospitals.

The coronavirus disease 2019 (COVID-19) pandemic presented unprecedented challenges to the New York City Health + Hospitals system. In addition to ramping up capacity and adapting operations quickly to handle the patient surge, NYC Health + Hospitals had to find new ways to provide emotional and psychological support for patients, families, and staff. To help families keep in touch, dedicated staff members provided daily updates by telephone and used tablets for virtual visits. An expanded palliative care team held virtual consultations with families to discuss advance care planning and end-of-life decisions. Bereavement hotlines were set up for families who lost loved ones. Enhanced staff support included one-on-one and group sessions with behavioral health specialists, a behavioral health hotline, a webinar series, and respite rooms, as well as complimentary lodging and child care. NYC Health + Hospitals created new rituals to celebrate recoveries and mourn losses. As regular operations resume, NYC Health + Hospitals plans to sustain and build on emotional and psychological support initiatives developed during the surge.
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http://dx.doi.org/10.1377/hlthaff.2020.00929DOI Listing
September 2020

Decreased salivary lactoferrin levels are specific to Alzheimer's disease.

EBioMedicine 2020 Jul 22;57:102834. Epub 2020 Jun 22.

Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain; Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain. Electronic address:

Background: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients.

Methods: To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.

Findings: The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911-0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET) versus healthy group, and 0•97 (0•924-1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0•93 (0•876-0•989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity.

Interpretation: Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.

Funding: Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B.
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http://dx.doi.org/10.1016/j.ebiom.2020.102834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378957PMC
July 2020

Complementary and Integrative Medicine Use in Individuals Seeking Conventional Medical Oncology Care in Chile: Prevalence and Patient Characteristics.

J Glob Oncol 2019 05;5:1-6

Clinica Alemana, Santiago, Chile.

Purpose: Complementary and integrative medicine (CIM) use during cancer care has increased in Western medical settings. Little is known about interest in and use of CIM approaches by oncology patients in Chile and South America.

Patients And Methods: Patients presenting for conventional outpatient or inpatient medical oncology care at the Clinica Alemana in Santiago, Chile, from March to June 2017 were asked to complete a survey about their interest in and use of CIM approaches. Goals included determining the prevalence of CIM use and exploring associations between CIM use and patient characteristics. Statistical analyses included a two-tailed test for continuous variables, Fischer's exact test for categorical variables, and logistic regression for association between CIM use and other variables.

Results: Of 432 patients surveyed, 66.9% were diagnosed with breast cancer, 84.8% were women, the majority of patients (58.1%) were between age 40 and 60 years, and 51.5% (n = 221) reported CIM use. No association was found between CIM use and the sociodemographic variables of sex, age, education, or income. In all, 44.6% of patients with breast cancer reported CIM use compared with 64.8% of patients with other cancer types ( > .001). Most commonly reported types of CIM used included herbals (49.1%), vitamins and minerals (40.8%), and prayer or meditation (40.4%). Most frequent reasons for CIM use were to "do everything possible" (72%) and to "improve my immune function" (67.8%). Most patients (43.4%) reported starting CIM use at the time of cancer diagnosis, with only 55.4% sharing information regarding CIM use with their medical team.

Conclusion: The majority of patients surveyed reported engaging in CIM use, with just over half the users communicating with their oncology team about their CIM use. Increased awareness of regional differences in CIM use may help increase communication regarding this subject and contribute to improved outcomes.
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http://dx.doi.org/10.1200/JGO.18.00190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550051PMC
May 2019

Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments.

Curr Pharm Des 2017 ;23(35):5392-5402

Departamento de Quimica Fisica Aplicada, Facultad de Ciencias, Universidad Autonoma de Madrid, C/ Francisco Tomas y Valiente 7, 28049 Madrid, Spain.

Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes. Another important pillar of cancer therapy in which magnetic nanoparticles can be successfully employed is the hyperthermia induced either magnetically or by infrared irradiation. In addition, recent works have suggested that magnetic nanoparticles can be used for mechanical stimulation of cells affecting their viability. Most of these applications require modification of the physiochemical and surface properties of the magnetic nanoparticles to control their biodistribution, toxicity and pharmacokinetics. In relation to this, polymer coatings are probably the preference alternative to cover the magnetic nanoparticles for cancer treatment applications. In this review, we attempt to provide an overview of the recent advances in the development and applications of polymeric magnetic nanoparticles in cancer treatment and diagnosis including MRI, drug delivery, magnetic hyperthermia, photothermia and magnetolysis.
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http://dx.doi.org/10.2174/1381612823666170519115601DOI Listing
April 2019

Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells.

Redox Biol 2017 08 4;12:719-726. Epub 2017 Apr 4.

Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.

The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (HO) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hence, the purpose of present study is to clarify whether HO alters these parameters. Human neuroblastoma SH-SY5Y cells were treated with HO (1-1000µM) for 24h and AChE activity and AChE and cytochrome c levels were evaluated. AChE activity was strongly increased from 1µM to 1000µM of HO The results of the kinetic study showed that HO affected Vmax but not Km; and also that HO changed the sigmoid kinetic observed in control samples to hyperbolic kinetic. Thus, results suggest that HO acts as an allosteric activators. In addition, HO, (100-1000µM) reduced the total AChE content and modified its isoform profile (mainly 50-, 70-, and 132-kDa)·HO from 100µM to 1000µM induced cytochrome c release confirming cell death by apoptosis. All these results together suggest: a) the involvement of oxidative stress in the imbalance of AChE; and b) treatment with antioxidant agents may be a suitable strategy to protect cholinergic system alterations promoted by oxidative stress.
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http://dx.doi.org/10.1016/j.redox.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390663PMC
August 2017

[Intestinal and peritoneal tuberculosis in a non-immunocompromised patient].

Gastroenterol Hepatol 2016 Nov 30;39(9):645-646. Epub 2016 Mar 30.

Servicio de Aparato Digestivo, Hospital Universitario Río Hortega, Valladolid, España.

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http://dx.doi.org/10.1016/j.gastrohep.2016.02.009DOI Listing
November 2016

[Oncological results in high grade prostate cancer treated surgically].

Arch Esp Urol 2016 May;69(4):162-71

Service of Urology. Hospital Universitario La Paz. Madrid. Spain.

Objectives: Prostate cancer is considered a tumour with a long natural history. However, its high-risk variants exhibit variable behaviour. We analyse the factors that affect BR and CSS (multivariate, Kaplan Meier).

Methods: From 1997 to 2013, 657 patients were operated of a high-grade prostate cancer (pT2b 7.2%, pT3a 73%, pT3b 18.3%, pT4 1.5%). Gleason score was ≥8 in 23% of cases. Percentage of PSMs was 46.1%. Mean follow-up was 113 months (24-192).

Results: BR occurred in 36.5%. Patients with Gleason score <8, 31.7% had BR, Gleason ≥8 had BR in 48% (p<0.05). PSMs recurrence occurred in 48.9%, whereas 26.1% in NSM (p<0.05). If lymphadenectomy, BR occurred in 48.7%, if not 30.9% (p<0,05). In multivariate analysis, stage, Gleason≥8 and PSMs were independent factors for BR. Treatment of BR was 36.5% radiotherapy, 24.1% HT, and 21.2% both simultaneously. Active surveillance was performed in 13.3%. Disease progression (biochemical or radiological) occurred in 23.5%. CSS was 98.93%, pT4 was the stage with the greatest mortality (10%), followed by pT3b (3.4%), p<0.05. Patients with a Gleason score ≥8 accounted for 71% CSM (p<0,05). PSMs and lymphadenectomy didn't have repercussions for survival. In multivariate analysis, Gleason≥8 was independent factor for CSM.

Conclusions: Radical prostatectomy plays an important role in multi-modal approach with good oncological control at medium follow up. Gleason score ≥8 was the factor with the greatest effect on CSM. Lymphadenectomy didn't affect CSS.
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May 2016

Outcomes of three different vertical rectus muscle transposition procedures for complete abducens nerve palsy.

J AAPOS 2015 Apr 28;19(2):150-6. Epub 2015 Mar 28.

Departments of Ophthalmology and Vision Sciences, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: To compare the efficacy of three different vertical rectus muscle transposition (VRT) techniques performed as a sole procedure to correct ocular alignment and improve abduction in cases of complete abducens nerve palsy.

Methods: The medical records of patients with complete abducens nerve palsy who underwent one of three different VRT procedures without simultaneous medial rectus weakening over a period of 20 years were retrospectively reviewed. The following procedures were used: full-tendon transposition (FTT), FTT with 4 mm resections before reinsertion (FTTR), and FTT with myopexy sutures (FTTM). We recorded the pre- and postoperative alignments, limitations of adduction and abduction, and complications. Follow-up was at least 6 months.

Results: A total of 26 patients (age range, 8-74 years) were included: 25 unilateral and 1 bilateral. Follow-up ranged from 6 to 21 months. Among 25 patients having unilateral surgery, the mean changes in esotropia were: 36.0(Δ) for FTT (n = 9), 46.4(Δ) for FTTR (n = 7), and 41.3(Δ) for FTTM (n = 9). Mean improvements in abduction grading were 0.94 for FTT (9 eyes), 1.64 for FTTR (7 eyes), and 1.41 for FTTM (11 eyes). For both measures the means were not significantly different. Three patients (2 FTT and 1 FTTM) had new postoperative vertical tropias >3(Δ). Only 1 patient (with FTTR) had an overcorrection.

Conclusions: FTTR corrected the most esotropia and improved abduction to the greatest degree, with the advantages of a low risk of creating a new vertical deviation and avoiding the risks of extra scleral sutures.
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http://dx.doi.org/10.1016/j.jaapos.2015.01.007DOI Listing
April 2015

Identification of the major ACE-inhibitory peptides produced by enzymatic hydrolysis of a protein concentrate from cuttlefish wastewater.

Mar Drugs 2014 Mar 10;12(3):1390-405. Epub 2014 Mar 10.

Scientific Instrumentation Service (SICIM), Marine Research Institute (IIM-CSIC), r/ Eduardo Cabello, 6. Vigo, Galicia 36208, Spain.

The aim of this work was the purification and identification of the major angiotensin converting enzyme (ACE) inhibitory peptides produced by enzymatic hydrolysis of a protein concentrate recovered from a cuttlefish industrial manufacturing effluent. This process consisted on the ultrafiltration of cuttlefish softening wastewater, with a 10 kDa cut-off membrane, followed by the hydrolysis with alcalase of the retained fraction. Alcalase produced ACE inhibitors reaching the highest activity (IC₅₀ = 76.8 ± 15.2 μg mL⁻¹) after 8 h of proteolysis. Sequential ultrafiltration of the 8 h hydrolysate with molecular weight cut-off (MWCO) membranes of 10 and 1 kDa resulted in the increased activity of each permeate, with a final IC₅₀ value of 58.4 ± 4.6 μg mL⁻¹. Permeate containing peptides lower than 1 kDa was separated by reversed-phase high performance liquid chromatography (RP-HPLC). Four fractions (A-D) with potent ACE inhibitory activity were isolated and their main peptides identified using high performance liquid chromatography coupled to an electrospray ion trap Fourier transform ion cyclotron resonance-mass spectrometer (HPLC-ESI-IT-FTICR) followed by comparison with databases and de novo sequencing. The amino acid sequences of the identified peptides contained at least one hydrophobic and/or a proline together with positively charged residues in at least one of the three C-terminal positions. The IC₅₀ values of the fractions ranged from 1.92 to 8.83 μg mL⁻¹, however this study fails to identify which of these peptides are ultimately responsible for the potent antihypertensive activity of these fractions.
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http://dx.doi.org/10.3390/md12031390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967217PMC
March 2014

Toxicity of binary mixtures of oil fractions to sea urchin embryos.

J Hazard Mater 2013 Dec 3;263 Pt 2:431-40. Epub 2013 Oct 3.

Grupo de Reciclado y Valoración de Residuos (REVAL), Instituto de Investigaciones Marinas (IIM-CSIC), C/ Eduardo Cabello, 6. Vigo, Pontevedra, E-36208, Spain. Electronic address:

The assumption of additive toxicity for oil compounds is related to a narcotic mode of action. However, the joint toxicity of oil fractions has not been fully investigated. A fractionation of Maya crude oil into aliphatics, aromatics and polars was performed, fractions were dissolved in dimethyl sulfoxide (DMSO) and subsequently toxicity of single fractions and binary mixtures was assessed using the sea urchin embryo test. The descriptive ability of Concentration Addition (CA), Independent Action (IA) and modifications of both models for describing the joint toxicity of mixtures has also been evaluated. The hydrocarbon content extractable with dichloromethane of the fractions dissolved in DMSO was: 12.0 ± 1.8 mg mL(-1), 39.0 ± 0.5 mg mL(-1) and 20.5 ± 2.5 mg mL(-1) for aliphatics, aromatics and polars, respectively. The toxicity of the extracts in DMSO of the fractions as EC50 (μLL(-1)) was: aliphatics (165.8-242.3)
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http://dx.doi.org/10.1016/j.jhazmat.2013.09.059DOI Listing
December 2013

Effects of spill-treating agents on growth kinetics of marine microalgae.

J Hazard Mater 2013 Dec 13;263 Pt 2:374-81. Epub 2013 Jul 13.

Grupo de Reciclado y Valorización de Materiales Residuales (REVAL), Instituto de Investigacións Mariñas (CSIC), r/Eduardo Cabello, 6, Vigo 36208, Galicia, Spain. Electronic address:

The effects of four spill-treating agents (STAs) (CytoSol, Finasol(®) OSR 51, Agma OSD 569 and OD4000) on the growth kinetics of three marine microalgae (Isochrysis galbana, Chaetoceros gracilis, Phaeodactylum tricornutum) were studied. Chlorophyll a concentration and optical density at 700 nm were assessed to describe the logistic growth of algae in batch cultures. The optical density data were initially analyzed as described for standard algal growth inhibition tests and subsequently modelled by a bivariate model, as a function of time and dose, to assess the toxic effects on growth parameters. Increasing trends in EC50 and EC10 values with time were found with the standard approach. In 8 of the 11 tests, the lag phase (λ) or the time required to achieve half the maximum biomass (τ) was significantly dependent on the STA concentration. A global parameter (EC50,τ) was calculated to summarize the effects of STAs on growth parameters in the bivariate model. The ranking of sensitivity as EC50,τ values was I. galbana>C. gracilis>P. tricornutum. For all species tested, the least toxic agent was Agma OSD 569, followed by CytoSol. The mathematical model allowed successful ecotoxicological evaluation of chemicals on microalgal growth.
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http://dx.doi.org/10.1016/j.jhazmat.2013.07.010DOI Listing
December 2013

Does theorizing on reciprocal altruism apply to the relationships of individuals with a spinal cord injury?

Evol Psychol 2012 Dec 20;10(5):818-29. Epub 2012 Dec 20.

University of Groningen and Royal Netherlands Academy of Arts and Sciences, The Netherlands.

From the perspective of reciprocal altruism, we examined the role of reciprocity in the close relationships of people inflicted with a spinal cord injury (SCI) (n = 70). We focused on the help receiver rather than on the help giver. Participants perceived more reciprocity in relationships with friends than in relationships with the partner and with family members. In these last relationships, perceptions of indebtedness were more prevalent than perceptions of deprivation. However, most negative feelings were evoked by a lack of reciprocity in partner relationships, followed by family relationships, and next by friendships. Moreover, depression was especially associated with a lack of perceived reciprocity in the relationships with family, and somewhat less with a lack of perceived reciprocity in the relationship with the partner. These results underline the importance of reciprocity in relationships, but suggest that reciprocity may be more, rather than less important in partner and family relationships.
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December 2012

Recommendations on bioanalytical method stability implications of co-administered and co-formulated drugs by Global CRO Council for Bioanalysis (GCC).

Bioanalysis 2012 Sep;4(17):2117-26

Advion Bioanalytical Laboratories, Quintiles, NY, USA.

An open letter written by the Global CRO Council for Bioanalysis (GCC) describing the GCC survey results on stability data from co-administered and co-formulated drugs was sent to multiple regulatory authorities on 14 December 2011. This letter and further discussions at different GCC meetings led to subsequent recommendations on this topic of widespread interest within the bioanalytical community over the past 2 years.
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http://dx.doi.org/10.4155/bio.12.192DOI Listing
September 2012

Effects of dietary Bacillus subtilis, Tetraselmis chuii, and Phaeodactylum tricornutum, singularly or in combination, on the immune response and disease resistance of sea bream (Sparus aurata L.).

Fish Shellfish Immunol 2012 Aug 23;33(2):342-9. Epub 2012 May 23.

Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, Regional Campus of International Excellence Campus Mare Nostrum, Murcia, Spain.

Combined or individual effects of two microalgae (Phaeodactylum tricornutum and Tetraselmis chuii) and Bacillus subtilis on immune response, gene expression, and survival to challenge with Photobacterium damselae subsp. piscicida of gilthead sea bream were investigated. To test the capacity of B. subtilis to grow employing the microalgae polysaccharides as energy and carbon source, an in vitro assay was defined, and demonstrated that the digestion product of microalgae, mainly P. tricornutum, supported the growth of B. subtilis much better than glucose. For the in vivo study, fish were distributed in six equal groups (each of two replicates) and received one of the following experimental diets: C) control, non-supplemented diet; T) T. chuii 100 g kg(-1); P) P. tricornutum 100 g kg(-1); B) B. subtilis (10(7) cfu g(-1)); BT) B. subtilis (10(7) cfu g(-1))+T. chuii (100 g kg(-1)); and BP) B. subtilis (10(7) cfu g(-1))+P. tricornutum (100 g kg(-1)). The complement activity, serum IgM level, respiratory burst, phagocytic activity, and expression of seven selected immune-related genes in head-kidney were evaluated following two and four weeks of treatment. At the end of the feeding trial, fish were challenged by intraperitoneal injection of LD(50) concentration of P. damselae subsp. piscicida and mortality was recorded. This is the first study testing the immunomodulatory capacity of the microalgae used in the present work. The dietary applications of B. subtilis, T. chuii, and P. tricornutum, singly or in combination, may exhibit up-regulating effects on gilthead sea bream immune parameters. P. tricornutum demonstrated the highest immunostimulant activity. There were no significant differences between combination feeding and feeding ingredients separately. Our results demonstrated the potential of microalgae as immunostimulants for fish, although further studies regarding the implications and effects of a stimulated immune system against pathogens, especially the protective capacity against specific diseases, are necessary.
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http://dx.doi.org/10.1016/j.fsi.2012.05.004DOI Listing
August 2012

Prevalence and predictors of sexual aggression in dating relationships of adolescents and young adults.

Psicothema 2009 May;21(2):234-40

Universidad Autónoma de Madrid, Facultad de Psicología, Madrid, Spain.

Dyadic influences among the diverse forms of aggression in dating relationships of adolescents and young adults have been reported in various studies. The goal of this research was to extend a dyadic model of physical aggression against partners to sexual aggression against partners. An urban sample of 4,052 adolescents and young adults of both genders, between 16 and 26 years old, was used. The percentage of male aggressors was significantly higher than that of the females (35.7% vs. 14.9%) and the percentage of victimization was higher for the women (25.1% vs.21.7%). Sexual aggression and sexual victimization was almost solely psychological in nature, that is, verbal coercion. As predicted by the dyadic model of physical aggression in dating relationships, sexual victimization was best predicted by sexual aggression of the individuals in this study both for males and females.
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May 2009

Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia.

Neuromuscul Disord 2009 May 11;19(5):316-23. Epub 2009 Apr 11.

AP-HP, Institute of Myology, G-H Pitié-Salpêtrière, Paris, France.

We report the clinical, histological and genetic findings in 10 families (19 patients) presenting mutations in the valosin-containing protein (VCP). The mean age at onset was 42 years. The clinical pattern was characterized by an early involvement of the proximal upper limbs with scapular winging. Axial and lower limb muscles were often affected, whereas facial, oculobulbar muscles were spared. Ten patients were wheelchair bound after a mean disease course of 9 years and six patients required canes for walking. Two patients required mechanically assisted ventilation and seven patients had reduced vital capacity. There was no cardiac involvement. Paget's disease of bone was observed in eight patients and cognitive impairment in nine patients. Seven patients died as a consequence of weakness and respiratory distress. Muscle biopsy showed rimmed vacuolar myopathy. Genetic analysis revealed missense heterozygous mutations mostly located in exon 5 of the VCP gene, four of which were not previously reported. We observed intrafamilial and interfamilial variability in terms of severity, distribution of weakness and presence or not of Paget's disease or cognitive impairment.
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http://dx.doi.org/10.1016/j.nmd.2009.02.012DOI Listing
May 2009

Comparison of cardiovascular risk factors in young Spanish men between the 1980s and after the year 2000. Data from the AGEMZA study.

Rev Esp Cardiol 2008 Dec;61(12):1260-6

Unidad de Investigación Cardiovascular, Instituto Aragonés de Ciencias de Salud, Zaragoza, Spain.

Introduction And Objectives: To investigate the cardiovascular risk profile of a sample of young Spanish men taken in the 1980s, the initial AGEMZA study cohort, and to compare the findings with those in another sample with similar characteristics taken after 2000.

Methods: The two AGEMZA study cohorts comprised young men who were resident at the Zaragoza General Military Academy, where they were studying as aspiring cadets. A descriptive study of each cohort was carried out and the participants' anthropometric characteristics, sporting and dietary habits, exposure to toxins, and biochemical and lipid profiles were analyzed. Data on the prevalence of various risk factors were obtained for each cohort and the coronary disease risk was estimated using the Framingham equation.

Results: Comparison of data on 248 subjects from the current cohort with data on 260 from the initial cohort showed the following significant changes: weight (+6.03 kg), body mass index (BMI) (+1.57), cholesterol (+12.46 mg/dL), low-density lipoprotein cholesterol (+15.8 mg/dL), high-density lipoprotein cholesterol (-4.11 mg/dL), triglycerides (+3.64 mg/dL), apolipoprotein B (+24.8 mg/dL), estimated coronary disease risk in the next 10 years (+1/1000 individuals) and estimated coronary disease risk up to the age of 65 years (+23/1000 individuals). There were significant correlations between increases in weight and BMI and lipid profile alterations.

Conclusions: The lipid profile and BMI were worse in the current sample. These findings make it essential that preventive measures for young people should be introduced and that an increased effort should be made to develop programs aimed at either stopping the progressive rise in obesity or even preventing it altogether.
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http://dx.doi.org/10.1016/s1885-5857(09)60053-0DOI Listing
December 2008

Aggression in adolescent dating relationships: prevalence, justification, and health consequences.

J Adolesc Health 2007 Apr 20;40(4):298-304. Epub 2007 Feb 20.

Department of Biological Psychology and Health Psychology, Psychology Faculty, Autonomous University of Madrid, Madrid, Spain.

Purpose: To assess the prevalence of verbally and physically aggressive behaviors in dating relationships in a sample of Spanish adolescents.

Methods: Cross-sectional self-report data were obtained with The Modified Conflict Tactics Scale (MCTS) from a representative sample of 2416 adolescents and young adults of both genders, between ages of 16 and 20 years.

Results: The results showed that a significantly higher percentage of women engaged in verbal aggression (95.3% vs. 92.8%), whereas the males engaged in more severe physical aggression (4.6% vs. 2.0%) and produced worse consequences for their female partners' health (especially slight cuts/slight bruises, broken nose, black eye, broken bone and requiring medical treatment/hospitalization). Justification for aggression also revealed differential results. Whereas women said they attacked their partners while under the influence of emotional states of intense anger (22.4% vs. 13.9%), the males said they did so in response to aggression received (13.0% vs. 6.6%). The analysis of the group differences as a function of age showed that verbal aggression was very high and was not different across the age groups. In contrast, physical aggression decreased significantly across the age groups, but health consequences became more severe with age (e.g., broken nose, black eye, broken bone, went from 1% at 16 years to 4.5% at 20 years of age).

Conclusions: These differential tendencies of aggression typology for men and women help clinicians to develop preventive interventions for every age, with the aim of diminishing their continuity in future relationships.
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http://dx.doi.org/10.1016/j.jadohealth.2006.11.137DOI Listing
April 2007

Targets and dimensions of social comparison among people with spinal cord injury and other health problems.

Br J Health Psychol 2006 Nov;11(Pt 4):677-93

Department of Psychology, University of Groningen, Groningen, The Netherlands.

The present research examined comparison targets and comparison dimensions among two Spanish samples of individuals facing serious illnesses and diseases. In Study 1, 90 older patients (mean age 66.36) with various age-related diseases, particularly cardiovascular diseases and diabetes, indicated that they compared themselves most often with others with the same disease, next with others with another disease and least with people without health problems. They compared themselves more often on their mental state, symptoms and physical activities than on their social activities. Social comparison orientation (SCO) as an individual difference characteristic was associated with more frequent comparisons with particularly similar targets, and with more frequent comparisons of one's symptoms and physical activities. Neuroticism was correlated only with more comparisons of one's symptoms. Study 2 was conducted in a sample of 70 relatively young patients (mean age 43.97) with spinal cord injury (SCI). Overall, they compared themselves more often with others than the participants in Study 1, and they compared themselves to a similar extent with people with SCI as with people with another disease and with people without health problems. While they felt on average better off than people with other diseases and other people with SCI, people with SCI felt on average worse off than people without health problems. They compared themselves more often on physical activities than on any other dimension. Higher levels of stress and uncertainty were associated with more frequent comparisons with people without SCI, and with more frequent comparisons of one's mental state, one's symptoms and one's future perspectives. The discussion focuses on the theoretical relevance of the results for social comparison theory, and on the practical relevance of the findings for interventions.
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http://dx.doi.org/10.1348/135910705X81000DOI Listing
November 2006

Two mathematical models for the correction of carbohydrate and protein interference in the determination of uronic acids by the m-hydroxydiphenyl method.

Biotechnol Appl Biochem 2005 Jun;41(Pt 3):209-16

Instituto de Investigacións Mariñas (CSIC), r/Eduardo Cabello 6, Vigo-36208, Galicia, Spain.

The most common method in the routine determination of uronic acids, the m-hydroxydiphenyl reaction, recently adapted to rapid microplate analysis, has as a main inconvenience, in any one of their modalities, interferences due to the frequent presence of proteins and neutral carbohydrates in the samples. Corresponding corrections in the literature are unsatisfactory when applied to complex matrices, and further adaptation to the microplate analysis is not free from additional problems. With particular reference to hyaluronic acid, the interactions between the principal reactants and the interfering materials are studied kinetically under realistic conditions, and simple mathematical models are proposed which satisfactorily describe the experimental results and allow adequate corrections to be made.
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http://dx.doi.org/10.1042/BA20040127DOI Listing
June 2005

The aetiology of paediatric inflammatory vulvovaginitis.

Eur J Pediatr 2004 Feb 4;163(2):105-7. Epub 2003 Dec 4.

Servicio de Microbiología y Parasitología, Cra. de Meco s/n, Alcalá de Henares, 28805 Madrid, Spain.

Unlabelled: Vulvovaginitis is the most common gynaecological problem in prepubertal girls and clear-cut data on the microbial aetiology of moderate to severe infections are lacking. Many microorganisms have been reported in several studies, but frequently the paediatrician does not know the pathogenic significance of an isolate reported in vaginal specimens of girls with vulvovaginitis. A multicentre study was performed, selecting 74 girls aged 2 to 12 years old with a clinical picture of vulvovaginitis and inflammatory cells on Gram stain. All the specimens were cultured following standard microbiological techniques and the paediatricians completed a questionnaire to highlight risk factors after interviewing the parents or tutors. The data were compared with those obtained in a control group of 11 girls without vulvovaginitis attending a clinic. Streptococcus pyogenesand Haemophilus spp.were isolated in 47 and 12 cases, respectively. Upper respiratory infection in the previous month ( P<0.001) and vulvovaginitis in the previous year ( P<0.05) were identified as significant risk factors. Foreign bodies, sexual abuse, poor hygiene and bad socioeconomic situation were not identified as risk factors for the infection.

Conclusion: Paediatric inflammatory vulvovaginitis is mainly caused by pathogens of the upper respiratory tract and the most common risk factor for this infection is to have suffered an upper respiratory tract infection in the previous month.
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http://dx.doi.org/10.1007/s00431-003-1373-xDOI Listing
February 2004

Dyadic adjustment in parents of schizophrenics.

Eur Psychiatry 2003 Aug;18(5):233-40

Department of Personality, Assessment and Psychological Treatment, Faculty of Psychology, Avenida de Tolosa 70, 20018 San Sebastián, Guipúzcoa, Spain.

Objective: To study the dyadic adjustment in couples with a schizophrenic offspring.

Method: 140 married couples, 67 with children with schizophrenia, and two control groups: 41 couples without pathology and 32 couples with pathology, were assessed with the Dyadic Adjustment Scale, the Beck Depression Inventory and the Self-Rating Anxiety Scale.

Results: The couples with a schizophrenic offspring evidenced significantly worse dyadic adjustment than did the normal controls, especially low consensus and cohesion in husbands, and low cohesion and satisfaction in wives. Anxiety and depression in mothers of schizophrenics is significantly higher than in mothers of controls.

Discussion: These findings suggest that the poor dyadic adjustment of the parents with a schizophrenic offspring could be an effect of the burden.

Conclusion: The treatment on the schizophrenia should be supplemented by interventions aimed at parents' dyadic adjustment, and mothers' anxiety and depression, so that they can be in better conditions to help their child.
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http://dx.doi.org/10.1016/s0924-9338(03)00063-4DOI Listing
August 2003