Publications







Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.
Cancer Cell 2017 Aug;32(2):238-252.e9
Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:

Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.
Am J Pathol 2017 May 9;187(5):940-953. Epub 2017 Mar 9.
Microvascular and Molecular Neuro-Oncology Laboratory, New York University School of Medicine, New York, New York; Department of Neurosurgery, New York University School of Medicine, New York, New York; Division of Neuropathology, Department of Pathology, New York University School of Medicine, New York, New York; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, New York. Electronic address:



Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.
Acta Neuropathol Commun 2016 Sep 1;4(1):96. Epub 2016 Sep 1.
Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26, 6525, GA, Nijmegen, The Netherlands.


Technical feasibility of integrating 7 T anatomical MRI in image-guided radiotherapy of glioblastoma: a preparatory study.
MAGMA 2016 Jun 30;29(3):591-603. Epub 2016 Mar 30.
Department of Radiation Oncology (MAASTRO CLINIC), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Type 1 papillary renal cell carcinoma in a patient with schwannomatosis: Mosaic versus loss of SMARCB1 expression in respectively schwannoma and renal tumor cells.
Genes Chromosomes Cancer 2016 Apr 22;55(4):350-4. Epub 2016 Jan 22.
Department of Pathology, Nijmegen Center for Molecular Life Sciences (NCMLS), Radboud University Medical Center, Nijmegen, The Netherlands.


Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.
Neuro Oncol 2016 Mar 9;18(3):388-400. Epub 2015 Sep 9.
Department of Pathology, Rotterdam, the Netherlands (H.J.D., P.N.A., J.M.K., W.N.M.D.); Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands (P.J.F.); Groupe Hospitalier Pitie Salpetriere, Service de Neurologie Mazarin, Paris, France (M.S., A.I.); Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (P.W.); Department of Pathology, Free University Medical Center, Amsterdam, the Netherlands (P.W.); Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands (R.E.); Department of Pathology, UMCU, Utrecht, the Netherlands (W.S.); Department of Neurology, St. Elisabeth Hospital, Tilburg, the Netherlands (C.T.); European Organisation for Research and Treatment of Cancer Data Center, Brussels, Belgium (T.G.); Department of Neurology/Neuro-oncology, Erasmus MC Cancer Center, Rotterdam, the Netherlands (M.J.v.d.B.).

Re: a Word of Caution on New and Revolutionary Diagnostic Tests.
Cancer Cell 2016 Feb;29(2):143-4
Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; thromboDx B.V., 1098 EA Amsterdam, the Netherlands. Electronic address:

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Cell 2016 Feb;164(5):1060-1072
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.


RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.
Cancer Cell 2015 Nov 29;28(5):666-676. Epub 2015 Oct 29.
Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; thromboDx B.V., 1098 EA Amsterdam, the Netherlands. Electronic address:



Whole-genome copy-number analysis identifies new leads for chromosomal aberrations involved in the oncogenesis and metastastic behavior of uveal melanomas.
Melanoma Res 2015 Jun;25(3):200-9
Departments of aPathology bHuman Genetics cOphthalmology, Radboud University Medical Center dDepartment of Pathology, Canisius Wilhelmina Hospital, Nijmegen eDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands.


Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue.
J Neuropathol Exp Neurol 2015 May;74(5):390-400
From the Tumor Immunology Laboratory, Radboud Institute for Molecular Life Sciences (PRG, BMS, EDK-R, GJA); and Departments of Pathology (KV, PW) and Neurosurgery (HMJMP-B, ML), Radboud University Medical Center, Nijmegen; and Department of Pathology, VU University Medical Center, Amsterdam (PW), the Netherlands.

Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.
Pathol Oncol Res 2015 Apr 15;21(2):439-47. Epub 2014 Oct 15.
Department of Pathology, C66, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands,



Can excision of meningiomas be limited to resection of tumor and radiologically abnormal dura mater? Neuronavigation-guided biopsies of dural tail and seemingly normal dura mater, with a review of the literature.
World Neurosurg 2014 Dec 5;82(6):e832-6. Epub 2014 Jul 5.
Meningioma Group Amsterdam (MeGA), VU University Medical Center, Amsterdam, The Netherlands; Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.


The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.
Neuro Oncol 2014 Sep 6;16(9):1263-73. Epub 2014 Feb 6.
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (R.J.M., C.J.F.v.N.); Neurosurgical Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands (F.E.B., D.V., W.P.V.); Laboratory of Molecular Genetics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy (S.La., C.Z., A.B., F.E.B.); Department of Pathology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands (J.W.M.J., S.H.E.B.-S., P.W.); Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands (P.W.); Department of Neurogenetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (T.J.M.H.); Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (D.T., A.A.v.T.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands (W.P.V.); Department of Neurosurgery, St. Elisabeth Hospital Tilburg, The Netherlands (S.Le.); Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands (S.Le.); FIRC Institute of Molecular Oncology, Milan, Italy (A.B.)Present affiliation: Department of Clinical Genetics, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands (F.E.B.); Department of Pathology, Radboud University Medical Center Nijmegen, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands (A.A.v.T.); Department of Neurology, Radboud University Medical Centre Nijmegen, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands (S.H.E.B.-S.); Department of Pathology, Stichting PAMM, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands (J.W.M.J.).

Premature termination of SMARCB1 translation may be followed by reinitiation in schwannomatosis-associated schwannomas, but results in absence of SMARCB1 expression in rhabdoid tumors.
Acta Neuropathol 2014 Sep 17;128(3):439-48. Epub 2014 Apr 17.
Department of Genome Analysis, Academic Medical Center, Room K2-216, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands,



Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.
Sci Rep 2014 Jun 11;4:5260. Epub 2014 Jun 11.
1] Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands [2] Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands [3] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.


Clinical value of chromosome arms 19q and 11p losses in low-grade gliomas.
Neuro Oncol 2014 Mar 12;16(3):400-8. Epub 2013 Dec 12.
Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), UMRS 975, Inserm U 975, CNRS, UMR 7225, Université Pierre et Marie Curie, Paris, France (A.A., Y.M, C.C., B.B., K.M., K.H.-X., M.S., J.-Y.D., A.I.); Department of Neuropathology (H.A., K.M.); Department of Neurology 2-Mazarin (F.L.-D., K.H.-X., M.S., J.-Y.D., A.I.); Department of Neurosurgery, AP-HP, Groupe Hospitalier Pitié-Salpêtriére, Paris, France (L.C.); Department of Neurology (H.F.v.T., J.C.R.); Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands (I.S., P.W., B.Y.); Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands (P.W.).

SMARCB1 involvement in the development of leiomyoma in a patient with schwannomatosis.
Am J Surg Pathol 2014 Mar;38(3):421-5
*Department of Genome Analysis, Academic Medical Center ∥Department of Pathology, VU University Medical Center, Amsterdam §Department of Pathology, Nijmegen Center for Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands †Institute for Human Genetics, University Hospital Muenster, Muenster ‡Institute for Neuropathology, Evangelisches Krankenhaus, Bielefeld, Germany.

Multivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting.
Neuro Oncol 2013 Dec 24;15(12):1615-24. Epub 2013 Oct 24.
Corresponding Author: William Leenders, PhD, Dept of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Multiplex blood reporters for simultaneous monitoring of cellular processes.
Anal Chem 2013 Nov 16;85(21):10205-10. Epub 2013 Oct 16.
Experimental Therapeutics and Molecular Imaging Laboratory, Neuroscience Center, Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts 02129, United States.

MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951.
Clin Cancer Res 2013 Oct 15;19(19):5513-22. Epub 2013 Aug 15.
Authors' Affiliations: Departments of Neurology, Biostatistics, and Pathology, Neuro-Oncology Unit Erasmus MC, Rotterdam; AP-HP, Groupe Hospitalier Pitie Salpêtrière, Service de Neurologie 2 Mazarin and Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), Paris, France; Department of Pathology, UMCU, Utrecht; Department of Pathology, UMCG, Groningen; Department of Neurology, St. Elisabeth Hospital, Tilburg; Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen; Department of Pathology, Free University Medical Center, Amsterdam, the Netherlands; and European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium.







Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma.
FASEB J 2012 Jun 13;26(6):2639-47. Epub 2012 Mar 13.
Neuro-oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.




Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.
Cancer 2011 Jul 18;117(13):3014-26. Epub 2011 Jan 18.
Mixed Research Unit, UMR 975, INSERM, National Institute of Health and Medical Research-Pierre and Marie Curie University, Pitie-Salpetriere Group Hospital, Paris, France.




White Matter Lesions Are Not Related to β-Amyloid Deposition in an Autopsy-Based Study.
Curr Gerontol Geriatr Res 2011 8;2011:826862. Epub 2011 Dec 8.
Department of Neurology, Donders Centre for Neuroscience, Medical Centre, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands.



Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.
Neuro Oncol 2016 09 22;18(9):1253-64. Epub 2016 Mar 22.
Tumor Immunology Laboratory, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands (P.R.G., B.M.S., E.D.K.-R., G.J.A.); Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands (K.V., P.W.); Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands (S.A.J.H.B., M.L.); Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands (P.W.)

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models.
Mol Cancer Ther 2016 09 20;15(9):2166-74. Epub 2016 Jun 20.
Department of Pediatrics, Pediatric Hematology and Oncology, Cancer Center, Amsterdam, the Netherlands. Neuro-oncology Research Group Cancer Center, Amsterdam, the Netherlands.

Accurate Delineation of Glioma Infiltration by Advanced PET/MR Neuro-Imaging (FRONTIER Study): A Diagnostic Study Protocol.
Neurosurgery 2016 10;79(4):535-40
*Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; ‡Department of Physics & Medical Technology, VU University Medical Center, Amsterdam, the Netherlands; §Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands; ¶Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands; ‖Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands; #Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.




Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma.
Oncotarget 2017 09 31;8(36):60447-60452. Epub 2017 Jul 31.
VU University Medical Center, Department of Paediatrics, Division of Oncology/Haematology, Amsterdam, The Netherlands.

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