Pieter Mestdagh

Pieter Mestdagh

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Pieter Mestdagh

Publications by authors named "Pieter Mestdagh"

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SMARTer single cell total RNA sequencing.

Nucleic Acids Res 2019 Jun 19. Epub 2019 Jun 19.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1093/nar/gkz535DOI Listing
June 2019

Long noncoding RNA expression profiling in cancer: Challenges and opportunities.

Genes Chromosomes Cancer 2019 04 20;58(4):191-199. Epub 2019 Jan 20.

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/gcc.22709DOI Listing
April 2019

MicroRNA Expression Analysis Using Small RNA Sequencing Discovery and RT-qPCR-Based Validation.

Methods Mol Biol 2017 ;1654:197-208

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-7231-9_13DOI Listing
June 2018

Computational deconvolution of transcriptomics data from mixed cell populations.

Bioinformatics 2018 06;34(11):1969-1979

Center for Medical Genetics Ghent (CMGG), Ghent University, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1093/bioinformatics/bty019DOI Listing
June 2018

How long noncoding RNAs enforce their will on mitochondrial activity: regulation of mitochondrial respiration, reactive oxygen species production, apoptosis, and metabolic reprogramming in cancer.

Curr Genet 2018 Feb 6;64(1):163-172. Epub 2017 Sep 6.

Center for Medical Genetics, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00294-017-0744-1DOI Listing
February 2018

Discovering cancer vulnerabilities using high-throughput micro-RNA screening.

Nucleic Acids Res 2017 Dec;45(22):12657-12670

The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1093/nar/gkx1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728403PMC
December 2017

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche.

PLoS One 2013 27;8(6):e67411. Epub 2013 Jun 27.

San Raffaele Scientific Institute, Telethon Institute for Gene Therapy (TIGET), Milano, Italy ; Department of Experimental Medicine and Biochemical Sciences, Section of Biochemistry and Molecular Biology, University of Perugia, Perugia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694868PMC
October 2017

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Sci Rep 2017 10 9;7(1):12871. Epub 2017 Oct 9.

Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/s41598-017-13265-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634489PMC
October 2017

Reply: Direct Detection of Circulating MicroRNAs Unveiled the Absence of MicroRNA-218-5p in Smoker Subjects.

Am J Respir Crit Care Med 2017 08;196(4):533

1 Ghent University Hospital Ghent, Belgium and.

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http://dx.doi.org/10.1164/rccm.201701-0224LEDOI Listing
August 2017

MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy.

Diabetologia 2017 06 31;60(6):1114-1125. Epub 2017 Mar 31.

IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Via Stezzano 87, 24126, Bergamo, Italy.

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http://dx.doi.org/10.1007/s00125-017-4248-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423990PMC
June 2017

Long non-coding RNAs in cutaneous melanoma: clinical perspectives.

Oncotarget 2017 Jun;8(26):43470-43480

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.18632/oncotarget.16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522162PMC
June 2017

Zipper plot: visualizing transcriptional activity of genomic regions.

BMC Bioinformatics 2017 May 2;18(1):231. Epub 2017 May 2.

Center for Medical Genetics, Ghent University, De Pintelaan 185, Ghent, Belgium.

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http://dx.doi.org/10.1186/s12859-017-1651-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414305PMC
May 2017

MicroRNAs as future therapeutic targets in COPD?

Eur Respir J 2017 05 25;49(5). Epub 2017 May 25.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1183/13993003.00431-2017DOI Listing
May 2017

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

Authors:
Jan Van Deun Pieter Mestdagh Patrizia Agostinis Özden Akay Sushma Anand Jasper Anckaert Zoraida Andreu Martinez Tine Baetens Els Beghein Laurence Bertier Geert Berx Janneke Boere Stephanie Boukouris Michel Bremer Dominik Buschmann James B Byrd Clara Casert Lesley Cheng Anna Cmoch Delphine Daveloose Eva De Smedt Seyma Demirsoy Victoria Depoorter Bert Dhondt Tom A P Driedonks Aleksandra Dudek Abdou Elsharawy Ilaria Floris Andrew D Foers Kathrin Gärtner Abhishek D Garg Edward Geeurickx Jan Gettemans Farzaneh Ghazavi Bernd Giebel Tom Groot Kormelink Grace Hancock Hetty Helsmoortel Andrew F Hill Vincent Hyenne Hina Kalra David Kim Joanna Kowal Sandra Kraemer Petra Leidinger Carina Leonelli Yaxuan Liang Lien Lippens Shu Liu Alessandra Lo Cicero Shaun Martin Suresh Mathivanan Prabhu Mathiyalagan Támas Matusek Gloria Milani Marta Monguió-Tortajada Liselot M Mus Dillon C Muth Andrea Németh Esther N M Nolte-'t Hoen Lorraine O'Driscoll Roberta Palmulli Michael W Pfaffl Bjarke Primdal-Bengtson Erminia Romano Quentin Rousseau Susmita Sahoo Natalia Sampaio Monisha Samuel Benjamin Scicluna Bieke Soen Anneleen Steels Johannes V Swinnen Maarit Takatalo Safia Thaminy Clotilde Théry Joeri Tulkens Isabel Van Audenhove Susanne van der Grein Alan Van Goethem Martijn J van Herwijnen Guillaume Van Niel Nadine Van Roy Alexander R Van Vliet Niels Vandamme Suzanne Vanhauwaert Glenn Vergauwen Frederik Verweij Annelynn Wallaert Marca Wauben Kenneth W Witwer Marijke I Zonneveld Olivier De Wever Jo Vandesompele An Hendrix

Nat Methods 2017 02;14(3):228-232

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/nmeth.4185DOI Listing
February 2017

MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2017 01;195(1):43-56

1 Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1164/rccm.201506-1182OCDOI Listing
January 2017

decodeRNA- predicting non-coding RNA functions using guilt-by-association.

Database (Oxford) 2017 01;2017

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1093/database/bax042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502368PMC
January 2017

Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell-Specific Long Noncoding RNAs.

Am J Pathol 2016 09 14;186(9):2462-72. Epub 2016 Jul 14.

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.05.011DOI Listing
September 2016

Renal microRNA- and RNA-profiles in progressive chronic kidney disease.

Eur J Clin Invest 2016 Mar 21;46(3):213-26. Epub 2016 Jan 21.

Department of Internal Medicine IV - Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/eci.12585DOI Listing
March 2016

Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment.

Cancer Lett 2016 Mar 17;372(1):128-36. Epub 2015 Dec 17.

Pediatric Research Group, Department of Clinical Medicine, Faculty of Health Science, The Arctic University of Norway - UiT, NO-9037 Tromsø, Norway; Department of Pediatrics, Division of Child and Adolescent Health, UNN - University Hospital of North-Norway, NO-9038 Tromsø, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.026DOI Listing
March 2016

RT-qPCR-based quantification of small non-coding RNAs.

Methods Mol Biol 2015 ;1296:85-102

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-2547-6_9DOI Listing
December 2015

Non-coding RNAs in the pathogenesis of COPD.

Thorax 2015 Aug 20;70(8):782-91. Epub 2015 May 20.

Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206560DOI Listing
August 2015

Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.

PLoS One 2014 4;9(12):e113842. Epub 2014 Dec 4.

Laboratory of Protein Chemistry, Proteomics and Epigenetic Signalling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Antwerp, Belgium; Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, Ghent, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256227PMC
July 2015

MiR-34a deficiency accelerates medulloblastoma formation in vivo.

Int J Cancer 2015 May 25;136(10):2293-303. Epub 2014 Nov 25.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Hufelandstr. 55 45147, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29294DOI Listing
May 2015

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression.

Stem Cells 2015 May;33(5):1377-89

Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/stem.1958DOI Listing
May 2015

Identification of miRNAs contributing to neuroblastoma chemoresistance.

Comput Struct Biotechnol J 2015 29;13:307-19. Epub 2015 Apr 29.

Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1016/j.csbj.2015.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427660PMC
May 2015

Non-coding RNAs and respiratory disease.

Thorax 2015 Apr 5;70(4):388-90. Epub 2014 Nov 5.

Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206404DOI Listing
April 2015

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Int J Cancer 2015 Mar 5;136(6):1308-20. Epub 2014 Aug 5.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1002/ijc.29091DOI Listing
March 2015

An update on LNCipedia: a database for annotated human lncRNA sequences.

Nucleic Acids Res 2015 Jan 5;43(Database issue):D174-80. Epub 2014 Nov 5.

Center for Medical Genetics, Ghent University, Ghent 9000, Belgium

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http://dx.doi.org/10.1093/nar/gku1060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383901PMC
January 2015

Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level.

Int J Cancer 2014 Dec 14;135(12):2868-77. Epub 2014 May 14.

Department of Respiratory Medicine, Tumor Immunology Laboratory, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Ghent, Belgium; Department of Respiratory Medicine, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/ijc.28945DOI Listing
December 2014

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling.

J Extracell Vesicles 2014 18;3. Epub 2014 Sep 18.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.3402/jev.v3.24858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169610PMC
October 2014

Early targets of miR-34a in neuroblastoma.

Mol Cell Proteomics 2014 Aug 9;13(8):2114-31. Epub 2014 Jun 9.

From the ‡Centro di Ingegneria Genetica e Biotecnologie Avanzate (CEINGE), 80145 Naples, Italy; §Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, 80131 Naples, Italy; ‖‖Centro di Medicina Trasfusionale, Azienda Ospedaliera Federico II, 80131 Naples, Italy

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http://dx.doi.org/10.1074/mcp.M113.035808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125741PMC
August 2014

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

Int J Cancer 2013 Sep 7;133(5):1064-73. Epub 2013 Mar 7.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.28091DOI Listing
September 2013

Regulatory microRNA network identification in bovine blastocyst development.

Stem Cells Dev 2013 Jul 15;22(13):1907-20. Epub 2013 Mar 15.

Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium.

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https://www.liebertpub.com/doi/10.1089/scd.2012.0708
Publisher Site
http://dx.doi.org/10.1089/scd.2012.0708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685315PMC
July 2013

Identification of miR-145 as a key regulator of the pigmentary process.

J Invest Dermatol 2013 Jan 16;133(1):201-9. Epub 2012 Aug 16.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/jid.2012.266DOI Listing
January 2013

Accurate RT-qPCR gene expression analysis on cell culture lysates.

Sci Rep 2012 13;2:222. Epub 2012 Jan 13.

Center for Medical Genetics, Ghent University Hospital , 9000 Ghent, Belgium.

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http://dx.doi.org/10.1038/srep00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257325PMC
September 2012

microRNAs in colon cancer: a roadmap for discovery.

FEBS Lett 2012 Sep;586(19):3000-7

Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.febslet.2012.07.048DOI Listing
September 2012

miRNA expression profiling: from reference genes to global mean normalization.

Methods Mol Biol 2012 ;822:261-72

Biogazelle, Zwijnaarde, Belgium.

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http://dx.doi.org/10.1007/978-1-61779-427-8_18DOI Listing
April 2012

Whole-genome RT-qPCR microRNA expression profiling.

Methods Mol Biol 2012 ;815:121-30

Center for Medical Genetics, Ghent University, De Pintelaan 185, Ghent 9000, Belgium.

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http://dx.doi.org/10.1007/978-1-61779-424-7_10DOI Listing
March 2012

The microRNA body map: dissecting microRNA function through integrative genomics.

Nucleic Acids Res 2011 Nov 10;39(20):e136. Epub 2011 Aug 10.

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium and Life Technologies, Foster City, CA, USA.

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http://dx.doi.org/10.1093/nar/gkr646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203610PMC
November 2011

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2011 Apr 29;183(7):898-906. Epub 2010 Oct 29.

Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1164/rccm.201002-0304OCDOI Listing
April 2011

IL-1β potently stabilizes IL-6 mRNA in human astrocytes.

Biochem Pharmacol 2011 Apr 12;81(8):1004-15. Epub 2011 Feb 12.

Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), University of Ghent, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.bcp.2011.01.019DOI Listing
April 2011

Predicting outcomes for children with neuroblastoma.

Discov Med 2010 Jul;10(50):29-36

Center for Medical Genetics, Ghent University Hospital, Ghent, B-9000, Belgium.

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July 2010

MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer.

BMC Cancer 2010 Apr 29;10:173. Epub 2010 Apr 29.

Department of Surgery, National University of Ireland, Galway, Republic of Ireland.

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http://dx.doi.org/10.1186/1471-2407-10-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873395PMC
April 2010

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.

Nat Cell Biol 2010 Mar 21;12(3):247-56. Epub 2010 Feb 21.

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ncb2024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845545PMC
March 2010