Pieter J M Leenen

Amsterdam University Medical Centers, University of Amsterdam, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

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March 2021

Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv.

Authors:

Bas C Mourik Jurriaan E M de Steenwinkel Gerjo J de Knegt Ruth Huizinga Annelies Verbon Tom H M Ottenhoff Dick van Soolingen Pieter J M Leenen

Sci Rep 2019 12 27;9(1):19922. Epub 2019 Dec 27.

Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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December 2019

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

Authors:

Adriaan A van Beek Jan Van den Bossche Pier G Mastroberardino Menno P J de Winther Pieter J M Leenen

Trends Immunol 2019 02 6;40(2):113-127. Epub 2019 Jan 6.

Department of Immunology, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

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February 2019

Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors.

Authors:

Changbin Zhu Dana A M Mustafa Merle M Krebber Ihsan Chrifi Pieter J M Leenen Dirk J Duncker Lennard Dekker Theo M Luider Johan M Kros Caroline Cheng

Oncotarget 2018 Sep 11;9(71):33500-33514. Epub 2018 Sep 11.

Division of Experimental Cardiology, Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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September 2018

Three-dimensional tubule formation assay as therapeutic screening model for ocular microvascular disorders.

Authors:

Mahnaz Shariatzadeh Maarten M Brandt Caroline Cheng Josianne C Ten Berge Aniki Rothova Pieter J M Leenen Willem A Dik

Eye (Lond) 2018 08 10;32(8):1380-1386. Epub 2018 May 10.

Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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August 2018

The interplay between critical transcription factors and microRNAs in the control of normal and malignant myelopoiesis.

Authors:

Christiaan J Stavast Pieter J M Leenen Stefan J Erkeland

Cancer Lett 2018 07 16;427:28-37. Epub 2018 Apr 16.

Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

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July 2018

Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.

Authors:

Anne H van der Spek Olga V Surovtseva Kin Ki Jim Adri van Oudenaren Matthijs C Brouwer Christina M J E Vandenbroucke-Grauls Pieter J M Leenen Diederik van de Beek Arturo Hernandez Eric Fliers Anita Boelen

Endocrinology 2018 05;159(5):2241-2252

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, AZ Amsterdam, Netherlands.

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May 2018

Pharmacodynamic Monitoring of Tacrolimus-Based Immunosuppression in CD14+ Monocytes After Kidney Transplantation.

Authors:

Nynke M Kannegieter Dennis A Hesselink Marjolein Dieterich Gretchen N de Graav Rens Kraaijeveld Ajda T Rowshani Pieter J M Leenen Carla C Baan

Ther Drug Monit 2017 10;39(5):463-471

Departments of *Internal Medicine and †Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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October 2017

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states.

Authors:

Behiye Özcan Pieter J M Leenen Patric J D Delhanty Lucy Y Baldéon-Rojas Sebastian J Neggers Aart Jan van der Lely

Diabetol Metab Syndr 2017 31;9:43. Epub 2017 May 31.

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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May 2017

Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression.

Authors:

Changbin Zhu Dana Mustafa Ping-Pin Zheng Marcel van der Weiden Andrea Sacchetti Maarten Brandt Ihsan Chrifi Dennie Tempel Pieter J M Leenen Dirk Jan Duncker Caroline Cheng Johan M Kros

Neuro Oncol 2017 05;19(5):648-659

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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May 2017

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.

Authors:

Bas C Mourik Erik Lubberts Jurriaan E M de Steenwinkel Tom H M Ottenhoff Pieter J M Leenen

Front Immunol 2017 5;8:294. Epub 2017 Apr 5.

Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.

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April 2017

CD16+ Monocytes and Skewed Macrophage Polarization toward M2 Type Hallmark Heart Transplant Acute Cellular Rejection.

Authors:

Thierry P P van den Bosch Kadir Caliskan Marina D Kraaij Alina A Constantinescu Olivier C Manintveld Pieter J M Leenen Jan H von der Thüsen Marian C Clahsen-van Groningen Carla C Baan Ajda T Rowshani

Front Immunol 2017 24;8:346. Epub 2017 Mar 24.

Department of Internal Medicine and Transplantation, Erasmus University Medical Center , Rotterdam , Netherlands.

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March 2017

The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function.

Authors:

Nynke M Kannegieter Dennis A Hesselink Marjolein Dieterich Rens Kraaijeveld Ajda T Rowshani Pieter J M Leenen Carla C Baan

PLoS One 2017 25;12(1):e0170806. Epub 2017 Jan 25.

Department of Internal Medicine, Section of Transplantation and Nephrology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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August 2017

Supplementation with WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Mice.

Authors:

Adriaan A van Beek Bruno Sovran Floor Hugenholtz Ben Meijer Joanne A Hoogerland Violeta Mihailova Corine van der Ploeg Clara Belzer Mark V Boekschoten Jan H J Hoeijmakers Wilbert P Vermeij Paul de Vos Jerry M Wells Pieter J M Leenen Claudio Nicoletti Rudi W Hendriks Huub F J Savelkoul

Front Immunol 2016 7;7:408. Epub 2016 Oct 7.

Cell Biology and Immunology Group, Wageningen University, Wageningen, Netherlands; Top Institute Food and Nutrition, Wageningen, Netherlands.

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October 2016

Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.

Authors:

Bas C Mourik Pieter J M Leenen Gerjo J de Knegt Ruth Huizinga Bram C J van der Eerden Jinshan Wang Charles R Krois Joseph L Napoli Irma A J M Bakker-Woudenberg Jurriaan E M de Steenwinkel

Am J Respir Cell Mol Biol 2017 Feb;56(2):233-241

1 Department of Medical Microbiology and Infectious Diseases.

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February 2017

The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking Outside the Cell but Also Outside the Islet and Out of the Box.

Authors:

Hemmo A Drexhage Wim A Dik Pieter J M Leenen Marjan A Versnel

Diabetes 2016 08;65(8):2130-3

Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.

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August 2016

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging mice.

Authors:

Adriaan A van Beek Floor Hugenholtz Ben Meijer Bruno Sovran Olaf Perdijk Wilbert P Vermeij Renata M C Brandt Sander Barnhoorn Jan H J Hoeijmakers Paul de Vos Pieter J M Leenen Rudi W Hendriks Huub F J Savelkoul

J Leukoc Biol 2017 04 14;101(4):811-821. Epub 2016 Jul 14.

Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands.

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April 2017

Langerhans cell histiocytosis is a neoplasm and consequently its recurrence is a relapse: In memory of Bob Arceci.

Authors:

R Maarten Egeler Satyendra Katewa Pieter J M Leenen Peter Beverley Matthew Collin Florent Ginhoux Robert J Arceci Barrett J Rollins

Pediatr Blood Cancer 2016 10 17;63(10):1704-12. Epub 2016 Jun 17.

Division of Medical Oncology, Dana-Farber Cancer Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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October 2016

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.

Authors:

Bram C J van der Eerden W Nadia H Koek Paul Roschger M Carola Zillikens Jan H Waarsing Annemiete van der Kemp Marijke Schreuders-Koedam Nadja Fratzl-Zelman Pieter J M Leenen Joost G J Hoenderop Klaus Klaushofer René J M Bindels Johannes P T M van Leeuwen

Oncotarget 2016 May;7(18):24928-41

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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May 2016

IL-1β differently stimulates proliferation and multinucleation of distinct mouse bone marrow osteoclast precursor subsets.

Authors:

Yixuan Cao Ineke D C Jansen Sara Sprangers Jan Stap Pieter J M Leenen Vincent Everts Teun J de Vries

J Leukoc Biol 2016 09 8;100(3):513-23. Epub 2016 Mar 8.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands;

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September 2016

Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D.

Authors:

Lucy Baldeón Rojas Karin Weigelt Harm de Wit Behiye Ozcan Adri van Oudenaren Fernando Sempértegui Eric Sijbrands Laura Grosse Anton-Jan van Zonneveld Hemmo A Drexhage Pieter J M Leenen

Diabetol Metab Syndr 2016 15;8. Epub 2016 Jan 15.

Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.

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January 2016

Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation.

Authors:

Lucy Baldeón R Karin Weigelt Harm de Wit Behiye Ozcan Adri van Oudenaren Fernando Sempértegui Eric Sijbrands Laura Grosse Anton-Jan van Zonneveld Hemmo A Drexhage Pieter J M Leenen

PLoS One 2015 17;10(6):e0129421. Epub 2015 Jun 17.

Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.

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April 2016

Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients.

Authors:

Lucy Baldeón R Karin Weigelt Harm de Wit Behiye Ozcan Adri van Oudenaren Fernando Sempértegui Eric Sijbrands Laura Grosse Wilma Freire Hemmo A Drexhage Pieter J M Leenen

PLoS One 2014 12;9(12):e115209. Epub 2014 Dec 12.

Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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March 2016

Immune suppression via glucocorticoid-stimulated monocytes: a novel mechanism to cope with inflammation.

Authors:

Georg Varga Jan Ehrchen Anne Brockhausen Toni Weinhage Nadine Nippe Michael Belz Athanasios Tsianakas Matthias Ross Dominik Bettenworth Tilmann Spieker Marc Wolf Ralph Lippe Klaus Tenbrock Pieter J M Leenen Johannes Roth Cord Sunderkötter

J Immunol 2014 Aug 2;193(3):1090-9. Epub 2014 Jul 2.

Institute of Immunology, University of Muenster, 48149 Muenster, Germany; Department of Dermatology, University of Muenster, 48149 Muenster, Germany;

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August 2014

M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone.

Authors:

Teun J De Vries Ton Schoenmaker David Aerts Lilyanne C Grevers Pedro P C Souza Kamran Nazmi Mark van de Wiel Bauke Ylstra Peter L Van Lent Pieter J M Leenen Vincent Everts

J Cell Physiol 2015 Jan;230(1):210-25

Department of Periodontology, University of Amsterdam VU University, MOVE Research Institute, Amsterdam, The Netherlands; Department of Oral Cell Biology, University of Amsterdam VU University, MOVE Research Institute, Amsterdam, The Netherlands.

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January 2015

Human monocytes produce interferon-gamma upon stimulation with LPS.

Authors:

Marina D Kraaij Elly J F Vereyken Pieter J M Leenen Thierry P P van den Bosch Farhad Rezaee Michiel G H Betjes Carla C Baan Ajda T Rowshani

Cytokine 2014 May 26;67(1):7-12. Epub 2014 Feb 26.

Department of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

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May 2014

MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells.

Authors:

Joey Riepsaame Adri van Oudenaren Berlinda J H den Broeder Wilfred F J van Ijcken Joris Pothof Pieter J M Leenen

Front Immunol 2013 30;4:353. Epub 2013 Oct 30.

Department of Immunology, Erasmus University Medical Center , Rotterdam , Netherlands.

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November 2013

Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection.

Authors:

Vania B L Moura Mayara M Silva Lucas F Batista Clayson M Gomes Pieter J M Leenen Ruy S Lino Milton A P Oliveira

Exp Parasitol 2013 Nov 30;135(3):599-605. Epub 2013 Sep 30.

Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235 S/N, Setor Universitário, 74605-050 Goiânia, Goiás, Brazil. Electronic address:

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November 2013

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