Piet H Van der Graaf

Piet H Van der Graaf

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Piet H Van der Graaf

Piet H Van der Graaf

Publications by authors named "Piet H Van der Graaf"

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Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

J Pharmacol Exp Ther 2019 Oct 1;371(1):15-24. Epub 2019 Aug 1.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (R.C.v.W., E.H.J.K., V.K., T.K., A.C.H., T.H., P.H.v.d.G.) and Animal Sciences and Health, Institute of Biology Leiden (A.O., H.P.S.), Leiden University, Leiden, The Netherlands; and Certara QSP, Canterbury, United Kingdom (P.H.v.d.G.)

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http://dx.doi.org/10.1124/jpet.119.260299DOI Listing
October 2019

Optimization of Cancer Treatment in the Frequency Domain.

AAPS J 2019 Sep 11;21(6):106. Epub 2019 Sep 11.

Systems Biomedicine & Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-019-0372-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739279PMC
September 2019

Pharmacometrics and/or Systems Pharmacology.

CPT Pharmacometrics Syst Pharmacol 2019 Jun 2;8(6):331-332. Epub 2019 Feb 2.

Certara, Canterbury, UK.

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http://doi.wiley.com/10.1002/psp4.12376
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http://dx.doi.org/10.1002/psp4.12376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618093PMC
June 2019

Mathematical Biology Models of Parkinson's Disease.

CPT Pharmacometrics Syst Pharmacol 2019 Feb 2;8(2):77-86. Epub 2018 Nov 2.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389348PMC
February 2019

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Sci Rep 2019 Feb 15;9(1):2149. Epub 2019 Feb 15.

Animal Sciences and Health, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-019-38530-w
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http://dx.doi.org/10.1038/s41598-019-38530-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609PMC
February 2019

Children Are Not Small Adults, but Can We Treat Them As Such?

CPT Pharmacometrics Syst Pharmacol 2019 Jan 28;8(1):34-38. Epub 2019 Jan 28.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center of Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363065PMC
January 2019

The implications of target saturation for the use of drug-target residence time.

Nat Rev Drug Discov 2018 12;18(1):82-84

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nrd.2018.234DOI Listing
December 2018

The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials.

Clin Pharmacol Ther 2018 11 14;104(5):797. Epub 2018 Jul 14.

Certara QSP, Canterbury Innovation Centre, Canterbury, UK.

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http://dx.doi.org/10.1002/cpt.1145DOI Listing
November 2018

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling.

Br J Pharmacol 2018 10 31;175(19):3832-3843. Epub 2018 Aug 31.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bph.14452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135786PMC
October 2018

Model reduction in mathematical pharmacology : Integration, reduction and linking of PBPK and systems biology models.

J Pharmacokinet Pharmacodyn 2018 08 26;45(4):537-555. Epub 2018 Mar 26.

Department of Mathematics and Statistics, University of Reading, Reading, RG6 6AX, UK.

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http://dx.doi.org/10.1007/s10928-018-9584-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061126PMC
August 2018

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

J Pharmacokinet Pharmacodyn 2018 08 18;45(4):621-635. Epub 2018 May 18.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10928-018-9593-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061075PMC
August 2018

Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction.

Br J Pharmacol 2018 08 10;175(16):3394-3406. Epub 2018 Jul 10.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bph.14385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057900PMC
August 2018

Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies.

CPT Pharmacometrics Syst Pharmacol 2018 05 25;7(5):285-287. Epub 2018 Apr 25.

Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980533PMC
May 2018

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

CPT Pharmacometrics Syst Pharmacol 2018 03 5;7(3):175-185. Epub 2018 Feb 5.

Division Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/psp4.12273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869561PMC
March 2018

Crowdsourced Asparagus Urinary Odor Population Kinetics.

CPT Pharmacometrics Syst Pharmacol 2018 01 14;7(1):34-41. Epub 2017 Dec 14.

Takeda Pharmaceuticals International Co, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/psp4.12264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784735PMC
January 2018

Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans.

Pharm Res 2018 Jan 8;35(2):26. Epub 2018 Jan 8.

Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s11095-017-2336-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783989PMC
January 2018

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

AAPS J 2017 12 4;20(1):11. Epub 2017 Dec 4.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-017-0172-7DOI Listing
December 2017

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Eur J Pharm Sci 2017 Nov 11;109S:S15-S21. Epub 2017 May 11.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.018DOI Listing
November 2017

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Eur J Pharm Sci 2017 Nov 12;109S:S32-S38. Epub 2017 May 12.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.027DOI Listing
November 2017

Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways.

Eur J Pharm Sci 2017 Nov 24;109S:S140-S148. Epub 2017 May 24.

Mathematical Institute, Leiden University, PB 9512, Leiden 2300RA, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.049DOI Listing
November 2017

A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

Eur J Pharm Sci 2017 Nov 7;109S:S161-S167. Epub 2017 Jun 7.

Certara QSP, Canterbury Innovation Centre, Canterbury CT2 7FG, UK; Systems Pharmacology Cluster, Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2017.06.009DOI Listing
November 2017

Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models.

CPT Pharmacometrics Syst Pharmacol 2017 Nov 28. Epub 2017 Nov 28.

Systems Biomedicine & Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/psp4.12266
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http://dx.doi.org/10.1002/psp4.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824121PMC
November 2017

A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback.

J Math Biol 2017 07 10;75(1):33-84. Epub 2016 Nov 10.

Leiden Academic Centre for Drug Research (LACDR), 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00285-016-1073-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487209PMC
July 2017

Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends.

Bull Math Biol 2017 Jul 27;79(7):1449-1486. Epub 2017 Jun 27.

Department of Mathematics and Statistics, University of Reading, Reading, RG6 6AX, UK.

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http://dx.doi.org/10.1007/s11538-017-0277-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498684PMC
July 2017

A combined model reduction algorithm for controlled biochemical systems.

BMC Syst Biol 2017 02 13;11(1):17. Epub 2017 Feb 13.

Department of Mathematics and Statistics, University of Reading, Reading, RG6 6AX, UK.

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http://dx.doi.org/10.1186/s12918-017-0397-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307760PMC
February 2017

Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling.

AAPS J 2017 01 26;19(1):274-285. Epub 2016 Oct 26.

Systems Pharmacology, Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, PO box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-016-0002-3DOI Listing
January 2017

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Zebrafish 2016 12 15;13(6):504-510. Epub 2016 Sep 15.

1 Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/zeb.2016.1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124745PMC
December 2016

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Metabolomics 2017 19;13(1). Epub 2016 Dec 19.

Division of Analytical Biosciences, Systems Pharmacology Cluster, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-016-1143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165030PMC
December 2016

Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.

Pharmacol Res Perspect 2016 12 17;4(6):e00270. Epub 2016 Nov 17.

Systems Pharmacology Leiden Academic Centre for Drug Research (LACDR) Leiden University Leiden The Netherlands; Certara Quantitative Systems Pharmacology Canterbury United Kingdom.

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http://dx.doi.org/10.1002/prp2.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226282PMC
December 2016

Have many estimates of efficacy and affinity been misled? Revisiting the operational model of agonism.

Drug Discov Today 2016 11 24;21(11):1735-1739. Epub 2016 Jun 24.

Laboratory of Molecular Neuropharmacology and Bioinformatics, Institut de Neurociències and Unitat de Bioestadística, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.06.019DOI Listing
November 2016

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

Trends Pharmacol Sci 2016 10 6;37(10):831-842. Epub 2016 Jul 6.

Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.06.008DOI Listing
October 2016

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

Expert Opin Drug Discov 2016 20;11(1):45-63. Epub 2015 Oct 20.

a Division of Pharmacology, Leiden Academic Centre for Drug Research , Leiden University , Einsteinweg 55, 2333 CC Leiden , The Netherlands.

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http://dx.doi.org/10.1517/17460441.2016.1100163DOI Listing
September 2016

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.

Br J Clin Pharmacol 2016 06 1;81(6):1113-23. Epub 2016 Apr 1.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bcp.12901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876184PMC
June 2016

Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.

Pharm Res 2016 Apr 1;33(4):856-67. Epub 2015 Dec 1.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s11095-015-1832-xDOI Listing
April 2016

Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.

J Pharmacol Toxicol Methods 2015 Mar-Apr;72:1-10. Epub 2014 Dec 31.

Systems Pharmacology, Leiden Academic Center of Drug Research (LACDR), Leiden University, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vascn.2014.12.008DOI Listing
December 2015

The rise of systems pharmacology in drug discovery and development.

Future Med Chem 2014 28;6(16):1731-4. Epub 2014 Jul 28.

Xenologiq Ltd, Unit 43, Canterbury Innovation Centre, University Road, Canterbury, CT2 7FG, UK.

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http://dx.doi.org/10.4155/fmc.14.66DOI Listing
August 2015

Towards integrative systems pharmacology models in oncology drug development.

Drug Discov Today Technol 2015 Aug 16;15:1-8. Epub 2015 Jul 16.

Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2015.06.004DOI Listing
August 2015

A mathematical analysis of rebound in a target-mediated drug disposition model: I.without feedback.

J Math Biol 2014 May 17;68(6):1453-78. Epub 2013 Apr 17.

Department of Mathematics, University of Surrey, Guildford, UK.

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http://dx.doi.org/10.1007/s00285-013-0675-5DOI Listing
May 2014

Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point.

J Allergy Clin Immunol 2013 Oct 15;132(4):847-55.e1-5. Epub 2013 Jun 15.

Respiratory Research Group, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2013.04.042DOI Listing
October 2013

A4S: a user-friendly graphical tool for pharmacokinetic and pharmacodynamic (PK/PD) simulation.

Comput Methods Programs Biomed 2013 May 20;110(2):203-14. Epub 2012 Nov 20.

Pharmacokinetics and Modeling, Accelera S.r.l., Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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http://dx.doi.org/10.1016/j.cmpb.2012.10.006DOI Listing
May 2013

Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology.

Interface Focus 2013 Apr;3(2):20120071

Department of Pharmacokinetics, Dynamics and Metabolism , Pfizer Worldwide R&D , Boston, MA , USA ; Neusentis, Pfizer Global Clinical Pharmacology , The Portway Building, Granta Park, Cambridge CB21 6GS , UK ; Leiden Academic Centre for Drug Research (LACDR) , Leiden RA 2300 , The Netherlands.

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http://rsfs.royalsocietypublishing.org/cgi/doi/10.1098/rsfs.
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http://dx.doi.org/10.1098/rsfs.2012.0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638475PMC
April 2013

A mathematical model of the human menstrual cycle for the administration of GnRH analogues.

J Theor Biol 2013 Mar 1;321:8-27. Epub 2012 Dec 1.

Computational Systems Biology Group, Zuse Institute Berlin (ZIB), Berlin, Germany.

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http://dx.doi.org/10.1016/j.jtbi.2012.11.020DOI Listing
March 2013

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology.

J Math Biol 2013 Mar 2;66(4-5):719-42. Epub 2012 Dec 2.

Xenologiq Ltd, Unit 7, Denne Hill Business Park, Canterbury, Kent CT4 6HD, UK.

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http://dx.doi.org/10.1007/s00285-012-0620-zDOI Listing
March 2013

Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.

J Pharmacokinet Pharmacodyn 2012 Oct 12;39(5):463-77. Epub 2012 Jul 12.

Division of Pharmacology, Gorlaeus Laboratories, Leiden-Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10928-012-9262-4DOI Listing
October 2012

CPT: Pharmacometrics and Systems Pharmacology.

CPT Pharmacometrics Syst Pharmacol 2012 Sep 26;1:e8. Epub 2012 Sep 26.

Editor-in-Chief.

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http://dx.doi.org/10.1038/psp.2012.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603471PMC
September 2012

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Drug Discov Today 2012 May 29;17(9-10):419-24. Epub 2011 Dec 29.

Pfizer, Departments of Pharmacokinetics, Dynamics and Metabolism, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

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http://dx.doi.org/10.1016/j.drudis.2011.12.020DOI Listing
May 2012

Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C.

Br J Clin Pharmacol 2012 Jan;73(1):77-92

Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

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http://dx.doi.org/10.1111/j.1365-2125.2011.04047.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248258PMC
January 2012

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.

Drug Metab Dispos 2011 Dec 8;39(12):2275-82. Epub 2011 Sep 8.

Division of Pharmacology, Leiden-Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.111.040782
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http://dx.doi.org/10.1124/dmd.111.040782DOI Listing
December 2011

Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.

J Pharmacol Toxicol Methods 2011 May-Jun;63(3):304-13. Epub 2011 Mar 17.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global R&D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK.

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http://dx.doi.org/10.1016/j.vascn.2011.03.002DOI Listing
August 2011

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry.

Curr Top Med Chem 2011 ;11(4):404-18

Discovery DMPK & BAC, Lead Generation and Medicinal Chemistry, AstraZeneca R&D Mölndal, S-43183 Mölndal, Sweden.

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http://dx.doi.org/10.2174/156802611794480864DOI Listing
July 2011

Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting in vivo potency.

J Theor Biol 2011 Jul 6;281(1):113-21. Epub 2011 May 6.

Department of Mathematics, University of Surrey, Guildford, UK.

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http://dx.doi.org/10.1016/j.jtbi.2011.04.030DOI Listing
July 2011

Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.

Pharm Res 2011 Jul 11;28(7):1460-4. Epub 2011 May 11.

Pfizer, Department of Pharmacometrics, Global Clinical Pharmacology, IPC 096, Sandwich, CT13 9NJ, UK.

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http://dx.doi.org/10.1007/s11095-011-0467-9DOI Listing
July 2011

Impact of protein binding on receptor occupancy: a two-compartment model.

J Theor Biol 2010 Aug 2;265(4):657-71. Epub 2010 Jun 2.

Mathematical Institute, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jtbi.2010.05.035DOI Listing
August 2010

Optimising in vivo pharmacology studies--Practical PKPD considerations.

J Pharmacol Toxicol Methods 2010 Mar-Apr;61(2):146-56. Epub 2010 Feb 11.

PKPD Section, Drug discovery DMPK & BAC, CVGI, AstraZeneca R&D Mölndal, S-43183 Mölndal, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S105687191000018
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http://dx.doi.org/10.1016/j.vascn.2010.02.002DOI Listing
June 2010

Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice.

Antimicrob Agents Chemother 2010 Mar 22;54(3):1179-85. Epub 2009 Dec 22.

Department of Pharmacokinetics, Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Ramsgate Road, Sandwich, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00551-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825998PMC
March 2010

Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling.

Drug Metab Pharmacokinet 2009 ;24(1):3-15

LAP&P Consultants BV, Leiden, The Netherlands.

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July 2009

Impact of plasma-protein binding on receptor occupancy: an analytical description.

J Theor Biol 2009 Jan 2;256(2):253-62. Epub 2008 Oct 2.

Mathematical Institute, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jtbi.2008.09.014DOI Listing
January 2009

A non-parametric method to analyse time-course of effect in the absence of pharmacokinetic data: application to inhaled bronchodilators.

Eur J Pharm Sci 2008 Aug 1;34(4-5):250-6. Epub 2008 May 1.

Department of Clinical Pharmacology, Pfizer Inc., Ramsgate Road IPC 191, Sandwich, Kent CT13 9NJ, UK.

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http://dx.doi.org/10.1016/j.ejps.2008.04.007DOI Listing
August 2008

The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics.

Drug Discov Today 2007 Dec 19;12(23-24):1018-24. Epub 2007 Nov 19.

Pfizer, Department of Pharmacokinetics, Dynamics, and Metabolism (PDM), Sandwich CT13 NJ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S135964460700416
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http://dx.doi.org/10.1016/j.drudis.2007.10.002DOI Listing
December 2007

Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man.

Pharm Res 2007 Nov 31;24(11):2031-9. Epub 2007 May 31.

Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratory, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://link.springer.com/10.1007/s11095-007-9336-y
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November 2007

Current methods used to investigate G protein coupled receptor oligomerisation.

J Pharmacol Toxicol Methods 2006 Jul-Aug;54(1):26-35. Epub 2005 Dec 15.

Discovery Biology, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

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http://dx.doi.org/10.1016/j.vascn.2005.11.001DOI Listing
October 2006

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo.

Pharmacol Ther 2005 Apr 23;106(1):1-18. Epub 2004 Dec 23.

Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.pharmthera.2004.10.014DOI Listing
April 2005

Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.

J Pharmacol Exp Ther 2002 Dec;303(3):1130-7

Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratories, Leiden, The Netherlands.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.102.03679
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December 2002

Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan.

Eur J Pharmacol 2002 Jun;445(1-2):43-54

Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratory, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s0014-2999(02)01665-5DOI Listing
June 2002

A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.

J Pharmacol Exp Ther 2002 Jan;300(1):330-8

Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Sylvius Laboratory, Leiden, The Netherlands.

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January 2002