Pierre-Antoine Defossez

Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan; JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

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March 2019

Mechanisms of DNA Methyltransferase Recruitment in Mammals.

Authors:

Marthe Laisné Nikhil Gupta Olivier Kirsh Sriharsa Pradhan Pierre-Antoine Defossez

Genes (Basel) 2018 Dec 10;9(12). Epub 2018 Dec 10.

Epigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France.

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December 2018

Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.

Authors:

Claire Marchal Maud de Dieuleveult Claude Saint-Ruf Nadège Guinot Laure Ferry Sara T Olalla Saad Mariana Lazarini Pierre-Antoine Defossez Benoit Miotto

Oncogenesis 2018 Oct 11;7(10):82. Epub 2018 Oct 11.

INSERM, U1016, Institut Cochin, Paris, France.

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October 2018

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.

Authors:

Xingjie Ma Marine Warnier Clotilde Raynard Mylène Ferrand Olivier Kirsh Pierre-Antoine Defossez Nadine Martin David Bernard

Aging Cell 2018 Dec 14;17(6):e12831. Epub 2018 Sep 14.

Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.

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December 2018

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

Authors:

Benoit Miotto Claire Marchal Guillaume Adelmant Nadège Guinot Ping Xie Jarrod A Marto Lingqiang Zhang Pierre-Antoine Defossez

Nucleic Acids Res 2018 05;46(9):4392-4404

Univ. Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France.

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May 2018

[Unexpected roles for a methyl-binding protein in cancer].

Authors:

Ikrame Naciri Audrey Roussel-Gervais Pierre-Antoine Defossez Olivier Kirsh

Med Sci (Paris) 2017 Aug-Sep;33(8-9):714-716. Epub 2017 Sep 18.

Équipe « Dynamique de la méthylation de l'ADN des génomes eucaryotes », Centre épigénétique et destin cellulaire, UMR7216 CNRS, université Paris Diderot, université Sorbonne Paris Cité (USPC), 35, rue Hélène Brion, 75205 Paris Cedex 13, France.

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April 2019

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Mol Cell 2017 Aug 10;67(4):550-565.e5. Epub 2017 Aug 10.

Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France. Electronic address:

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August 2017

Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Authors:

Audrey Roussel-Gervais Ikrame Naciri Olivier Kirsh Laetitia Kasprzyk Guillaume Velasco Giacomo Grillo Pierre Dubus Pierre-Antoine Defossez

Cancer Res 2017 01 4;77(1):62-73. Epub 2016 Nov 4.

University Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, Paris, France.

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January 2017

MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.

Authors:

Marc Santolini Iori Sakakibara Morgane Gauthier Francesc Ribas-Aulinas Hirotaka Takahashi Tatsuya Sawasaki Vincent Mouly Jean-Paul Concordet Pierre-Antoine Defossez Vincent Hakim Pascal Maire

Nucleic Acids Res 2016 Oct 14;44(18):8621-8640. Epub 2016 Jun 14.

Institut Cochin, Université Paris-Descartes, Centre National de la Recherche Scientifique (CNRS), UMR 8104, Paris, France Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, Paris, France

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October 2016

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program.

Authors:

Mylène Ferrand Olivier Kirsh Audrey Griveau David Vindrieux Nadine Martin Pierre-Antoine Defossez David Bernard

Aging (Albany NY) 2015 Nov;7(11):986-1003

Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69373 Lyon, France.

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November 2015

The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.

Authors:

Benoit Miotto Moredreck Chibi Ping Xie Stéphane Koundrioukoff Hanlie Moolman-Smook David Pugh Michelle Debatisse Fuchu He Lingqiang Zhang Pierre-Antoine Defossez

Cell Rep 2014 Apr 13;7(2):575-587. Epub 2014 Apr 13.

Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France. Electronic address:

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April 2014

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.

Authors:

H Irem Baymaz Alexandra Fournier Sophie Laget Zongling Ji Pascal W T C Jansen Arne H Smits Laure Ferry Anneloes Mensinga Ina Poser Andrew Sharrocks Pierre-Antoine Defossez Michiel Vermeulen

Proteomics 2014 Oct 24;14(19):2179-89. Epub 2014 Apr 24.

Molecular Cancer Research, Cancer Genomics, University Medical Center Utrecht, Utrecht, The Netherlands.

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October 2014

MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.

Authors:

Sophie Laget Benoit Miotto Hang Gyeong Chin Pierre-Olivier Estève Richard J Roberts Sriharsa Pradhan Pierre-Antoine Defossez

Epigenetics 2014 Apr 16;9(4):546-56. Epub 2014 Jan 16.

Université Paris Diderot; Sorbonne Paris Cité; Epigenetics and Cell Fate; UMR 7216 CNRS; Paris, France.

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April 2014

Ceci n'est pas une DNMT: recently discovered functions of DNMT2 and their relation to methyltransferase activity (Comment on DOI 10.1002/bies.201300088).

Authors:

Pierre-Antoine Defossez

Bioessays 2013 Dec;35(12):1024

Université Paris, CNRs UMR7216, Paris, France.

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December 2013

[Epigenetic regulation in neuronal differentiation and brain function].

Authors:

Laetitia Kasprzyk Pierre-Antoine Defossez Benoît Miotto

Biol Aujourdhui 2013 23;207(1):1-17. Epub 2013 May 23.

Unité d'Épigénétique et Destin Cellulaire, CNRS UMR7216, Université Paris Diderot 35, rue Hélène Brion, 75205 Paris Cedex 13, France.

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January 2014

On how mammalian transcription factors recognize methylated DNA.

Authors:

Bethany A Buck-Koehntop Pierre-Antoine Defossez

Epigenetics 2013 Feb 16;8(2):131-7. Epub 2013 Jan 16.

Department of Chemistry, University of Utah, Salt Lake City, UT, USA.

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February 2013

The role of methyl-binding proteins in chromatin organization and epigenome maintenance.

Authors:

Alexandra Fournier Nobuhiro Sasai Mitsuyoshi Nakao Pierre-Antoine Defossez

Brief Funct Genomics 2012 May 19;11(3):251-64. Epub 2011 Dec 19.

Institut National du Cancer (INCa), CNRS UMR7216/Université Paris Diderot, Paris, France.

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May 2012

Biological functions of methyl-CpG-binding proteins.

Authors:

Pierre-Antoine Defossez Irina Stancheva

Prog Mol Biol Transl Sci 2011 ;101:377-98

CNRS UMR7216, Université Paris 7, Paris Cedex 13, France.

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August 2011

Mammalian methyl-binding proteins: what might they do?

Authors:

Michael Joulie Benoit Miotto Pierre-Antoine Defossez

Bioessays 2010 Dec 30;32(12):1025-32. Epub 2010 Sep 30.

CNRS UMR7216, Université Paris Diderot, Paris, France.

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December 2010

The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA.

Authors:

Sophie Laget Michael Joulie Florent Le Masson Nobuhiro Sasai Elisabeth Christians Sriharsa Pradhan Richard J Roberts Pierre-Antoine Defossez

PLoS One 2010 Aug 6;5(8):e11982. Epub 2010 Aug 6.

New England Biolabs, Ipswich, Massachusetts, United States of America.

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August 2010

Sequence-specific recognition of methylated DNA by human zinc-finger proteins.

Authors:

Nobuhiro Sasai Mitsuyoshi Nakao Pierre-Antoine Defossez

Nucleic Acids Res 2010 Aug 19;38(15):5015-22. Epub 2010 Apr 19.

CNRS UMR7216, Université Paris-Diderot, Paris, France.

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August 2010

Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes.

Authors:

Nobuhiro Sasai Pierre-Antoine Defossez

Int J Dev Biol 2009 ;53(2-3):323-34

CNRS UMR 218, Institut Curie, Paris, France.

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September 2009

Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.

Authors:

Qun Yu Holly Kuzmiak Yanfei Zou Lars Olsen Pierre-Antoine Defossez Xin Bi

J Biol Chem 2009 Jan 18;284(2):740-50. Epub 2008 Nov 18.

Department of Biology, University of Rochester, Rochester, New York 14627, USA.

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January 2009

[Master and servant: epigenetic deregulations as a cause and a consequence of cancer].

Authors:

Sophie Laget Pierre-Antoine Defossez

Med Sci (Paris) 2008 Aug-Sep;24(8-9):725-30

New England Biolabs, 240 County Road, Ipswich, MA 01938, Etats-Unis.

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December 2008

The cell biology of DNA methylation in mammals.

Authors:

Egor Prokhortchouk Pierre-Antoine Defossez

Biochim Biophys Acta 2008 Nov 28;1783(11):2167-73. Epub 2008 Jul 28.

Center BioEngineering, Russian Academy of Sciences, Prospekt 60-let Oktyabrya 7-1, 117312 Moscow, Russia.

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November 2008

Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.

Authors:

Axel Weber Judith Marquardt David Elzi Nicole Forster Sven Starke Andre Glaum Daisuke Yamada Pierre-Antoine Defossez Jeffrey Delrow Robert N Eisenman Holger Christiansen Martin Eilers

EMBO J 2008 Jun 1;27(11):1563-74. Epub 2008 May 1.

Institute of Molecular Biology and Tumour Research (IMT), Marburg, Germany.

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June 2008

Assessment of sera for chromatin-immunoprecipitation.

Authors:

Juliette Nguyen Daisuke Yamada David C Schultz Pierre-Antoine Defossez

Biotechniques 2008 Jan;44(1):66, 68

Centre National de la Recherche Scientifique, Paris, France.

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January 2008

Born to bind: the BTB protein-protein interaction domain.

Authors:

Roberto Perez-Torrado Daisuke Yamada Pierre-Antoine Defossez

Bioessays 2006 Dec;28(12):1194-202

CNRS UMR218, Institut Curie, Section Recherche, Paris, France.

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December 2006

Using reverse electrophoretic mobility shift assay to measure and compare protein-DNA binding affinities.

Authors:

Guillaume J P Filion Lucie Fouvry Pierre-Antoine Defossez

Anal Biochem 2006 Oct 4;357(1):156-8. Epub 2006 Aug 4.

CNRS UMR218, Institut Curie, Section recherche, 75248 Paris Cedex 05, France.

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October 2006

[Epigenetics and cancer].

Authors:

Guillaume J P Filion Pierre-Antoine Defossez

Bull Cancer 2006 Apr;93(4):343-7

CNRS UMR218, Institut Curie, Section Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05.

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April 2006

Histone H1 of Saccharomyces cerevisiae inhibits transcriptional silencing.

Authors:

Marie Veron Yanfei Zou Qun Yu Xin Bi Abdelkader Selmi Eric Gilson Pierre-Antoine Defossez

Genetics 2006 Jun 2;173(2):579-87. Epub 2006 Apr 2.

Section Recherche, Institut Curie, CNRS UMR218, Paris, France.

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June 2006

A family of human zinc finger proteins that bind methylated DNA and repress transcription.

Authors:

Guillaume J P Filion Svetlana Zhenilo Sergey Salozhin Daisuke Yamada Egor Prokhortchouk Pierre-Antoine Defossez

Mol Cell Biol 2006 Jan;26(1):169-81

Institut Curie, CNRS UMR218, Paris 75248, France.

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January 2006

The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso.

Authors:

Pierre-Antoine Defossez Kevin F Kelly Guillaume J P Filion Roberto Pérez-Torrado Frédérique Magdinier Hervé Menoni Curtis L Nordgaard Juliet M Daniel Eric Gilson

J Biol Chem 2005 Dec 17;280(52):43017-23. Epub 2005 Oct 17.

CNRS UMR5161, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France.

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December 2005

[Proteins binding to methylated DNA: interpreters of the epigenetic code].

Authors:

Guillaume Filion Pierre-Antoine Defossez

Med Sci (Paris) 2004 Jan;20(1):7-8

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January 2004

A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast.

Authors:

Eleonore Lebrun Geneviève Fourel Pierre-Antoine Defossez Eric Gilson

Mol Cell Biol 2003 Mar;23(5):1498-508

Laboratoire de Biologie Moléculaire de la Cellule, UMR5665, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 07, France.

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March 2003

The vertebrate protein CTCF functions as an insulator in Saccharomyces cerevisiae.

Authors:

Pierre-Antoine Defossez Eric Gilson

Nucleic Acids Res 2002 Dec;30(23):5136-41

CNRS UMR 5665, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.

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December 2002

General regulatory factors (GRFs) as genome partitioners.

Authors:

Genevieve Fourel Tsuyoshi Miyake Pierre-Antoine Defossez Rong Li Eric Gilson

J Biol Chem 2002 Nov 27;277(44):41736-43. Epub 2002 Aug 27.

CNRS/ENSL 5665, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, France.

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November 2002

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Authors:

Su-Ju Lin Matt Kaeberlein Alex A Andalis Lori A Sturtz Pierre-Antoine Defossez Valeria C Culotta Gerald R Fink Leonard Guarente

Nature 2002 Jul;418(6895):344-8

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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July 2002

Publications by authors named "Pierre-Antoine Defossez"

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