Publications by authors named "Pierre Sonveaux"

100Publications

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction.

Authors:
Arthur Colson Pierre Sonveaux Frédéric Debiève Amanda N Sferruzzi-Perri

Hum Reprod Update 2020 Dec 30. Epub 2020 Dec 30.

Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.

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December 2020

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.

Authors:
Céline A Schoonjans Barbara Mathieu Nicolas Joudiou Luca X Zampieri Davide Brusa Pierre Sonveaux Olivier Feron Bernard Gallez

J Clin Med 2020 Oct 15;9(10). Epub 2020 Oct 15.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain (Uclouvain), 1200 Brussels, Belgium.

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October 2020

Hypoxia-inducible factor 2 alpha impairs human cytotrophoblast syncytialization: New insights into placental dysfunction and fetal growth restriction.

Authors:
Arthur Colson Christophe Louis Depoix Pamela Baldin Corinne Hubinont Pierre Sonveaux Frédéric Debiève

FASEB J 2020 Nov 21;34(11):15222-15235. Epub 2020 Sep 21.

Pole of Obstetrics, Institute of Experimental and Clinical Research (IREC), UCLouvain, Brussels, Belgium.

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November 2020

Evidence of metabolic activity during low-temperature ovarian tissue preservation in different media.

Authors:
Janice de M V Vilela Marie-Madeleine Dolmans Emi Maruhashi Marine C N M Blackman Pierre Sonveaux Ana Luisa Miranda-Vilela Christiani A Amorim

J Assist Reprod Genet 2020 Oct 4;37(10):2477-2486. Epub 2020 Sep 4.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte B1.52.02, 1200, Brussels, Belgium.

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October 2020

The Risk of Arterial Thrombosis in Patients With Chronic Myeloid Leukemia Treated With Second and Third Generation BCR-ABL Tyrosine Kinase Inhibitors May Be Explained by Their Impact on Endothelial Cells: An In-Vitro Study.

Authors:
Hélène Haguet Céline Bouvy Anne-Sophie Delvigne Elise Modaffari Adeline Wannez Pierre Sonveaux Jean-Michel Dogné Jonathan Douxfils

Front Pharmacol 2020 3;11:1007. Epub 2020 Jul 3.

Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium.

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July 2020

Mitochondria in cancer.

Authors:
Debora Grasso Luca X Zampieri Tânia Capelôa Justine A Van de Velde Pierre Sonveaux

Cell Stress 2020 May 11;4(6):114-146. Epub 2020 May 11.

Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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May 2020

An EPR Study Using Cyclic Hydroxylamines To Assess The Level of Mitochondrial ROS in Superinvasive Cancer Cells.

Authors:
Samantha Scheinok Tania Capeloa Paolo E Porporato Pierre Sonveaux Bernard Gallez

Cell Biochem Biophys 2020 Sep 1;78(3):249-254. Epub 2020 Jun 1.

Biomedical Magnetic Resonance, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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September 2020

Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells.

Authors:
Luca X Zampieri Debora Grasso Caroline Bouzin Davide Brusa Rodrigue Rossignol Pierre Sonveaux

Mol Cancer Res 2020 09 29;18(9):1379-1391. Epub 2020 May 29.

Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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September 2020

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

Authors:
Léopold Thabault Lucie Brisson Chiara Brustenga Santiago A Martinez Gache Julien R C Prévost Arina Kozlova Quentin Spillier Maxime Liberelle Zohra Benyahia Joris Messens Tamara Copetti Pierre Sonveaux Raphaël Frédérick

J Med Chem 2020 05 15;63(9):4628-4643. Epub 2020 Apr 15.

Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCLouvain), B-1200 Brussels, Belgium.

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May 2020

Rosiglitazone Protects Endothelial Cells From Irradiation-Induced Mitochondrial Dysfunction.

Authors:
Bjorn Baselet Ronald B Driesen Emma Coninx Niels Belmans Tom Sieprath Ivo Lambrichts Winnok H De Vos Sarah Baatout Pierre Sonveaux An Aerts

Front Pharmacol 2020 13;11:268. Epub 2020 Mar 13.

Institute for Environment, Health and Safety, Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.

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March 2020

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells.

Authors:
Debora Grasso Hyllana C D Medeiros Luca X Zampieri Vanesa Bol Pierre Danhier Marike W van Gisbergen Caroline Bouzin Davide Brusa Vincent Grégoire Hubert Smeets Alphons P M Stassen Ludwig J Dubois Philippe Lambin Marie Dutreix Pierre Sonveaux

Front Pharmacol 2020 13;11:263. Epub 2020 Mar 13.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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March 2020

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer.

Authors:
Sofia Avnet Nicola Baldini Lucie Brisson Stine Falsig Pedersen Paolo E Porporato Pierre Sonveaux Gyorgy Szabadkai Silvia Pastorekova

Front Oncol 2019 28;9:1332. Epub 2019 Nov 28.

Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

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November 2019

Synthesis and characterization of a 5-membered ring cyclic hydroxylamine coupled to triphenylphosphonium to detect mitochondrial superoxide by EPR spectrometry.

Authors:
Samantha Scheinok Benoit Driesschaert Donatienne d'Hose Pierre Sonveaux Raphaël Robiette Bernard Gallez

Free Radic Res 2019 Dec 19;53(11-12):1135-1143. Epub 2019 Nov 19.

Université Catholique de Louvain (UCLouvain), Louvain Drug Research Institute (LDRI), Biomedical Magnetic Resonance, Brussels, Belgium.

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December 2019

Monocarboxylate transporters in cancer.

Authors:
Valéry L Payen Erica Mina Vincent F Van Hée Paolo E Porporato Pierre Sonveaux

Mol Metab 2020 03 27;33:48-66. Epub 2019 Jul 27.

Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium. Electronic address:

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March 2020

Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.

Authors:
Tamara V Milosevic Gaëlle Vertenoeil Valéry L Payen Pierre Sonveaux Paul M Tulkens Stefan N Constantinescu Françoise Van Bambeke

Int J Antimicrob Agents 2019 Nov 30;54(5):661-667. Epub 2019 Jul 30.

Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address:

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November 2019

Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.

Authors:
Cláudia Silva Ana Correia-Branco Nelson Andrade António Carlos Ferreira Miguel Luz Soares Pierre Sonveaux Jean Stephenne Fátima Martel

Eur J Pharmacol 2019 Sep 10;859:172533. Epub 2019 Jul 10.

Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. Electronic address:

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September 2019

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines.

Authors:
Tânia Capelôa Zohra Benyahia Luca X Zampieri Marine C N M Blackman Pierre Sonveaux

Semin Cell Dev Biol 2020 02 1;98:181-191. Epub 2019 Jul 1.

Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium. Electronic address:

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February 2020

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.

Authors:
Luigi Ippolito Andrea Morandi Maria Letizia Taddei Matteo Parri Giuseppina Comito Alessandra Iscaro Maria Rosaria Raspollini Francesca Magherini Elena Rapizzi Julien Masquelier Giulio G Muccioli Pierre Sonveaux Paola Chiarugi Elisa Giannoni

Oncogene 2019 07 1;38(27):5339-5355. Epub 2019 Apr 1.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.

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July 2019

Pro- and antitumor effects of mitochondrial reactive oxygen species.

Authors:
Valéry L Payen Luca X Zampieri Paolo E Porporato Pierre Sonveaux

Cancer Metastasis Rev 2019 06;38(1-2):189-203

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Avenue Hippocrate 57 box B1.57.04, 1200, Brussels, Belgium.

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June 2019

Pathological effects of ionizing radiation: endothelial activation and dysfunction.

Authors:
Bjorn Baselet Pierre Sonveaux Sarah Baatout An Aerts

Cell Mol Life Sci 2019 Feb 30;76(4):699-728. Epub 2018 Oct 30.

Radiobiology Unit, Belgian Nuclear Research Centre (SCK•CEN), Mol, Belgium.

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February 2019

Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells.

Authors:
Samantha Scheinok Philippe Leveque Pierre Sonveaux Benoit Driesschaert Bernard Gallez

Free Radic Res 2018 Oct 13;52(10):1182-1196. Epub 2018 Nov 13.

a Biomedical Magnetic Resonance , Université Catholique de Louvain, Louvain Drug Research Institute (LDRI) , Brussels , Belgium.

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October 2018

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism.

Authors:
Sofia Avnet Nicola Baldini Lucie Brisson Angelo De Milito Angela M Otto Silvia Pastoreková Paolo E Porporato Gyorgy Szabadkai Pierre Sonveaux

Front Oncol 2018 3;8:329. Epub 2018 Oct 3.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.

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October 2018

Acute iodine deficiency induces a transient VEGF-dependent microvascular response in mammary glands involving HIF-1, ROS, and mTOR.

Authors:
Jessica Vanderstraeten Hanane Derradji Pierre Sonveaux Ides M Colin Marie-Christine Many Anne-Catherine Gérard

Am J Physiol Cell Physiol 2018 10 18;315(4):C544-C557. Epub 2018 Jul 18.

Service d'Endocrino-Diabétologie, Centre Hospitalier Régional, Mons-Hainaut, Belgium.

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October 2018

Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function.

Authors:
Marie Bettonville Stefania d'Aria Kathleen Weatherly Paolo E Porporato Jinyu Zhang Sabrina Bousbata Pierre Sonveaux Michel Y Braun

Elife 2018 06 18;7. Epub 2018 Jun 18.

Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.

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June 2018

Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.

Authors:
Tamara V Milosevic Valéry L Payen Pierre Sonveaux Giulio G Muccioli Paul M Tulkens Françoise Van Bambeke

Antimicrob Agents Chemother 2018 03 23;62(3). Epub 2018 Feb 23.

Pharmacologie Cellulaire et Moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium

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March 2018

(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.

Authors:
Valéry L Payen Paolo E Porporato Pierre Danhier Thibaut Vazeille Marine C N M Blackman Bronislav H May Paul Niebes Pierre Sonveaux

Front Pharmacol 2017 4;8:869. Epub 2017 Dec 4.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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December 2017

Lactate stimulates CA IX expression in normoxic cancer cells.

Authors:
Elena Panisova Martin Kery Olga Sedlakova Lucie Brisson Michaela Debreova Martina Sboarina Pierre Sonveaux Silvia Pastorekova Eliska Svastova

Oncotarget 2017 Sep 12;8(44):77819-77835. Epub 2017 Sep 12.

Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

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September 2017

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.

Authors:
Sabrina Contino Paolo E Porporato Matthew Bird Claudia Marinangeli Rémi Opsomer Pierre Sonveaux Françoise Bontemps Ilse Dewachter Jean-Noël Octave Luc Bertrand Serena Stanga Pascal Kienlen-Campard

Front Physiol 2017 12;8:796. Epub 2017 Oct 12.

Alzheimer Research Group, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.

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October 2017

Differential Impact of Single-Dose Fe Ion and X-Ray Irradiation on Endothelial Cell Transcriptomic and Proteomic Responses.

Authors:
Bjorn Baselet Omid Azimzadeh Nadine Erbeldinger Mayur V Bakshi Till Dettmering Ann Janssen Svetlana Ktitareva Donna J Lowe Arlette Michaux Roel Quintens Kenneth Raj Marco Durante Claudia Fournier Mohammed A Benotmane Sarah Baatout Pierre Sonveaux Soile Tapio An Aerts

Front Pharmacol 2017 22;8:570. Epub 2017 Sep 22.

Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCK•CEN)Mol, Belgium.

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September 2017

Ffar2 expression regulates leukaemic cell growth in vivo.

Authors:
Laure B Bindels Paolo E Porporato Sarah Ducastel Martina Sboarina Audrey M Neyrinck Evelyne M Dewulf Olivier Feron Sophie Lestavel Patrice D Cani Bart Staels Pierre Sonveaux Nathalie M Delzenne

Br J Cancer 2017 Oct 5;117(9):1336-1340. Epub 2017 Sep 5.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73, Box B1.73.11, Brussels 1200, Belgium.

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October 2017

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Authors:
Silvia Lemma Gemma Di Pompo Paolo E Porporato Martina Sboarina Shonagh Russell Robert J Gillies Nicola Baldini Pierre Sonveaux Sofia Avnet

Biochim Biophys Acta Mol Basis Dis 2017 12 1;1863(12):3254-3264. Epub 2017 Sep 1.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address:

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December 2017

Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter.

Authors:
Valéry L Payen Myriam Y Hsu Kristin S Rädecke Elisabeth Wyart Thibaut Vazeille Caroline Bouzin Paolo E Porporato Pierre Sonveaux

Cancer Res 2017 10 21;77(20):5591-5601. Epub 2017 Aug 21.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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October 2017

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Authors:
Nicola Baldini Angelo De Milito Olivier Feron Robert J Gillies Carine Michiels Angela M Otto Silvia Pastoreková Stine F Pedersen Paolo E Porporato Pierre Sonveaux Claudiu T Supuran Sofia Avnet

Front Pharmacol 2017 4;8:411. Epub 2017 Jul 4.

Rizzoli Orthopaedic InstituteBologna, Italy.

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July 2017

Mitochondria in cancer.

Authors:
Giuseppe Gasparre Rodrigue Rossignol Pierre Sonveaux

Biochim Biophys Acta Bioenerg 2017 Aug;1858(8):553-555

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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August 2017

Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose.

Authors:
Bjorn Baselet Niels Belmans Emma Coninx Donna Lowe Ann Janssen Arlette Michaux Kevin Tabury Kenneth Raj Roel Quintens Mohammed A Benotmane Sarah Baatout Pierre Sonveaux An Aerts

Front Pharmacol 2017 25;8:213. Epub 2017 Apr 25.

Radiobiology Unit, Belgian Nuclear Research Centre (SCK•CEN), Institute for Environment, Health and SafetyMol, Belgium.

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April 2017

Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies.

Authors:
Pierre Danhier Gladys Deumer Nicolas Joudiou Caroline Bouzin Philippe Levêque Vincent Haufroid Bénédicte F Jordan Olivier Feron Pierre Sonveaux Bernard Gallez

Oncotarget 2017 Jun;8(24):38876-38885

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université Catholique de Louvain (UCL), Brussels, Belgium.

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June 2017

ROS and radiotherapy: more we care.

Authors:
Pierre Sonveaux

Oncotarget 2017 May;8(22):35482-35483

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.

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May 2017

Cancer metabolism in space and time: Beyond the Warburg effect.

Authors:
Pierre Danhier Piotr Bański Valéry L Payen Debora Grasso Luigi Ippolito Pierre Sonveaux Paolo E Porporato

Biochim Biophys Acta Bioenerg 2017 Aug 4;1858(8):556-572. Epub 2017 Feb 4.

Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52 box B1.53.09, 1200 Brussels, Belgium; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino Italy. Electronic address:

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August 2017

Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors.

Authors:
Vincent F Van Hée Daniel Labar Gwenaël Dehon Debora Grasso Vincent Grégoire Giulio G Muccioli Raphaël Frédérick Pierre Sonveaux

Oncotarget 2017 Apr;8(15):24415-24428

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL), B-1200 Brussels, Belgium.

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April 2017

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo.

Authors:
Marie-Aline Neveu Géraldine De Preter Valérie Marchand Anne Bol Jeffery R Brender Keita Saito Shun Kishimoto Paolo E Porporato Pierre Sonveaux Vincent Grégoire Olivier Feron Bénédicte F Jordan Murali C Krishna Bernard Gallez

Neoplasia 2016 Dec 24;18(12):742-752. Epub 2016 Nov 24.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain, Brussels, Belgium. Electronic address:

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December 2016

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.

Authors:
Andrea Cacace Martina Sboarina Thibaut Vazeille Pierre Sonveaux

Oncogene 2017 04 17;36(15):2074-2084. Epub 2016 Oct 17.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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April 2017

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer.

Authors:
Lucie Brisson Piotr Bański Martina Sboarina Coralie Dethier Pierre Danhier Marie-Joséphine Fontenille Vincent F Van Hée Thibaut Vazeille Morgane Tardy Jorge Falces Caroline Bouzin Paolo E Porporato Raphaël Frédérick Carine Michiels Tamara Copetti Pierre Sonveaux

Cancer Cell 2016 09;30(3):418-431

Institut de Recherche Expérimentale et Clinique (IREC), Pole of Pharmacology, Université catholique de Louvain (UCL), 1200 Brussels, Belgium. Electronic address:

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September 2016

Energy metabolism in osteoclast formation and activity.

Authors:
Silvia Lemma Martina Sboarina Paolo E Porporato Nicoletta Zini Pierre Sonveaux Gemma Di Pompo Nicola Baldini Sofia Avnet

Int J Biochem Cell Biol 2016 10 30;79:168-180. Epub 2016 Aug 30.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico Rizzoli (IOR), via di Barbiano 1/10, 40136 Bologna, Italy. Electronic address:

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October 2016

Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition.

Authors:
Aurelia De Pauw Paul Massion Belaid Sekkali Emilie Andre Caroline Dubroca Jana Kmecova Caroline Bouzin Ann Friart Catherine Sibille Patrick Gilon Delphine De Mulder Hrag Esfahani Adrien Strapart Ruben Martherus Valéry Payen Pierre Sonveaux Peter Brouckaert Stefan Janssens Jean-Luc Balligand

Cardiovasc Res 2016 10 12;112(1):478-90. Epub 2016 Aug 12.

Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Departement de Medecine Interne et Cliniques Saint-Luc, Université Catholique de Louvain, B1.53.09, 52 Ave. Mounier, 1200 Brussels, Belgium

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October 2016

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide.

Authors:
Paolo E Porporato Pierre Sonveaux

Mol Cell Oncol 2015 Jul-Sep;2(3):e968043. Epub 2014 Oct 29.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC); Université catholique de Louvain (UCL) ; Brussels, Belgium.

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June 2016

Channels and transporters in cell metabolism.

Authors:
Pierre Sonveaux Pierre Maechler Jean-Claude Martinou

Biochim Biophys Acta 2016 10 3;1863(10):2359-61. Epub 2016 Jun 3.

Department of Cell Biology, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland.

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October 2016

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.

Authors:
Tokuhiro Chano Sofia Avnet Katsuyuki Kusuzaki Gloria Bonuccelli Pierre Sonveaux Dante Rotili Antonello Mai Nicola Baldini

Am J Cancer Res 2016 15;6(4):859-75. Epub 2016 Mar 15.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico RizzoliBologna, Italy; Department of Biomedical and Neuromotor Sciences, University of BolognaBologna, Italy.

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May 2016

Monocarboxylate transporters in the brain and in cancer.

Authors:
Jhudit Pérez-Escuredo Vincent F Van Hée Martina Sboarina Jorge Falces Valéry L Payen Luc Pellerin Pierre Sonveaux

Biochim Biophys Acta 2016 10 16;1863(10):2481-97. Epub 2016 Mar 16.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52 box B1.53.09, 1200 Brussels, Belgium. Electronic address:

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October 2016

Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach.

Authors:
Jessica Vanderstraeten Hanane Derradji Julie Craps Pierre Sonveaux Ides M Colin Marie-Christine Many Anne-Catherine Gérard

Histol Histopathol 2016 Aug 3;31(8):897-909. Epub 2016 Feb 3.

Pole of Experimental Morphology, Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain (UCL), Brussels, Belgium and Department of Endocrinology and Diabetology, Regional Hospital Center (CHR) Mons-Hainaut, Belgium and Institute of life sciences (ISV), Catholic University of Louvain (UCL), Belgium.

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August 2016

Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro.

Authors:
Géraldine De Preter Pierre Danhier Paolo E Porporato Valéry L Payen Bénédicte F Jordan Pierre Sonveaux Bernard Gallez

Adv Exp Med Biol 2016 ;876:209-214

Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Avenue Mounier 73 (B1.73.08), 1200, Brussels, Belgium.

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May 2016

A Fast Hydrogen Sulfide-Releasing Donor Increases the Tumor Response to Radiotherapy.

Authors:
Géraldine De Preter Caroline Deriemaeker Pierre Danhier Lucie Brisson Thanh Trang Cao Pham Vincent Grégoire Bénédicte F Jordan Pierre Sonveaux Bernard Gallez

Mol Cancer Ther 2016 Jan 18;15(1):154-61. Epub 2015 Dec 18.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain, Brussels, Belgium.

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January 2016

Application of Electron Paramagnetic Resonance (EPR) Oximetry to Monitor Oxygen in Wounds in Diabetic Models.

Authors:
Céline M Desmet Aurore Lafosse Sophie Vériter Paolo E Porporato Pierre Sonveaux Denis Dufrane Philippe Levêque Bernard Gallez

PLoS One 2015 14;10(12):e0144914. Epub 2015 Dec 14.

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

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July 2016

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.

Authors:
Paolo E Porporato Valéry L Payen Bjorn Baselet Pierre Sonveaux

Cell Mol Life Sci 2016 Apr 8;73(7):1349-63. Epub 2015 Dec 8.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52, box B1.53.09, 1200, Brussels, Belgium.

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April 2016

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.

Authors:
Jhudit Pérez-Escuredo Rajesh K Dadhich Suveera Dhup Andrea Cacace Vincent F Van Hée Christophe J De Saedeleer Martina Sboarina Fabien Rodriguez Marie-Joséphine Fontenille Lucie Brisson Paolo E Porporato Pierre Sonveaux

Cell Cycle 2016 ;15(1):72-83

a From the Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCL) Medical School , Brussels , Belgium.

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October 2016

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.

Authors:
Valéry L Payen Paolo E Porporato Bjorn Baselet Pierre Sonveaux

Cell Mol Life Sci 2016 Apr 1;73(7):1333-48. Epub 2015 Dec 1.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 52, box B1.53.09, 1200, Brussels, Belgium.

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April 2016

Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.

Authors:
Lionel Mignion Pierre Danhier Julie Magat Paolo E Porporato Julien Masquelier Vincent Gregoire Giulio G Muccioli Pierre Sonveaux Bernard Gallez Bénédicte F Jordan

Int J Cancer 2016 Apr 9;138(8):2043-9. Epub 2015 Dec 9.

Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique De Louvain (UCL), Avenue Mounier, 73 Box B1.73.08, Brussels, Belgium.

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April 2016

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation.

Authors:
Géraldine De Preter Marie-Aline Neveu Pierre Danhier Lucie Brisson Valéry L Payen Paolo E Porporato Bénédicte F Jordan Pierre Sonveaux Bernard Gallez

Oncotarget 2016 Jan;7(3):2910-20

Louvain Drug Research Institute (LDRI), Biomedical Magnetic Resonance Research Group, Université Catholique de Louvain (UCL), Brussels, Belgium.

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January 2016

Lactate does not activate NF-κB in oxidative tumor cells.

Authors:
Vincent F Van Hée Jhudit Pérez-Escuredo Andrea Cacace Tamara Copetti Pierre Sonveaux

Front Pharmacol 2015 13;6:228. Epub 2015 Oct 13.

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain (UCL) Medical School Brussels, Belgium.

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November 2015

Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds.

Authors:
Kiran Kumar Chereddy Alessandra Lopes Salome Koussoroplis Valéry Payen Claudia Moia Huijun Zhu Pierre Sonveaux Peter Carmeliet Anne des Rieux Gaëlle Vandermeulen Véronique Préat

Nanomedicine 2015 Nov 31;11(8):1975-84. Epub 2015 Jul 31.

Louvain Drug Research Institute (LDRI) Advanced Drug Delivery and Biomaterials, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

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November 2015

Common responses of tumors and wounds to hypoxia.

Authors:
Valéry L Payen Lucie Brisson Mark W Dewhirst Pierre Sonveaux

Cancer J 2015 Mar-Apr;21(2):75-87

From the *Pole of Pharmacology & Therapeutics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL) Medical School, Brussels, Belgium; and †Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC.

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December 2015

In vivo visualization and ex vivo quantification of murine breast cancer cells in the mouse brain using MRI cell tracking and electron paramagnetic resonance.

Authors:
Pierre Danhier Julie Magat Philippe Levêque Géraldine De Preter Paolo E Porporato Caroline Bouzin Bénédicte F Jordan Gladys Demeur Vincent Haufroid Olivier Feron Pierre Sonveaux Bernard Gallez

NMR Biomed 2015 Mar 22;28(3):367-75. Epub 2015 Jan 22.

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Brussels, Belgium.

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March 2015

Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors.

Authors:
Fabienne Danhier Pierre Danhier Christophe J De Saedeleer Anne-Catherine Fruytier Nathalie Schleich Anne des Rieux Pierre Sonveaux Bernard Gallez Véronique Préat

Int J Pharm 2015 Feb 8;479(2):399-407. Epub 2015 Jan 8.

Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Avenue Mounier, 73, B1 73.12, 1200 Brussels, Belgium. Electronic address:

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February 2015

Proton channels and exchangers in cancer.

Authors:
Enrico Pierluigi Spugnini Pierre Sonveaux Christian Stock Mario Perez-Sayans Angelo De Milito Sofia Avnet Abel Garcìa Garcìa Salvador Harguindey Stefano Fais

Biochim Biophys Acta 2015 Oct 20;1848(10 Pt B):2715-26. Epub 2014 Oct 20.

Anti-Cancer Drug Section, Department of Drug Research and Medicine Evaluation, Istituto Superiore di Sanità (National Institute of Health), Rome, Italy. Electronic address:

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October 2015

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

Authors:
Kiran Kumar Chereddy Charles-Henry Her Michela Comune Claudia Moia Alessandra Lopes Paolo E Porporato Julie Vanacker Martin C Lam Lars Steinstraesser Pierre Sonveaux Huijun Zhu Lino S Ferreira Gaëlle Vandermeulen Véronique Préat

J Control Release 2014 Nov 27;194:138-47. Epub 2014 Aug 27.

Université catholique de Louvain, Louvain Drug Research Institute (LDRI), Advanced Drug Delivery and Biomaterials, Avenue E. Mounier 73 box B1.73.12, 1200 Brussels, Belgium. Electronic address:

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November 2014

A mitochondrial switch promotes tumor metastasis.

Authors:
Paolo E Porporato Valéry L Payen Jhudit Pérez-Escuredo Christophe J De Saedeleer Pierre Danhier Tamara Copetti Suveera Dhup Morgane Tardy Thibaut Vazeille Caroline Bouzin Olivier Feron Carine Michiels Bernard Gallez Pierre Sonveaux

Cell Rep 2014 Aug 24;8(3):754-66. Epub 2014 Jul 24.

Institut de Recherche Expérimentale et Clinique (IREC), Pole of Pharmacology (FATH), Université catholique de Louvain (UCL), Brussels 1200, Belgium. Electronic address:

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August 2014

Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.

Authors:
Vanesa Bol Anne Bol Caroline Bouzin Daniel Labar John A Lee Guillaume Janssens Paolo E Porporato Pierre Sonveaux Olivier Feron Vincent Grégoire

Acta Oncol 2015 Feb 9;54(2):266-74. Epub 2014 Jul 9.

Center for Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL) , Brussels , Belgium.

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February 2015

Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.

Authors:
Nihed Draoui Olivier Schicke Emmanuel Seront Caroline Bouzin Pierre Sonveaux Olivier Riant Olivier Feron

Mol Cancer Ther 2014 Jun 26;13(6):1410-8. Epub 2014 Mar 26.

Authors' Affiliations: Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels; and Molecules, Solids and Reactivity (MOST), Institute of Condensed Matter and Nanosciences (IMCN), Université catholique de Louvain, Louvain-la-Neuve, Belgium

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June 2014

Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.

Authors:
Pierre Danhier Géraldine De Preter Julie Magat Quentin Godechal Paolo E Porporato Bénédicte F Jordan Olivier Feron Pierre Sonveaux Bernard Gallez

Contrast Media Mol Imaging 2014 Mar-Apr;9(2):143-53

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Brussels, Belgium.

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October 2014

Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.

Authors:
Lars Steinstraesser Martin C Lam Frank Jacobsen Paolo E Porporato Kiran Kumar Chereddy Mustafa Becerikli Ingo Stricker Robert Ew Hancock Marcus Lehnhardt Pierre Sonveaux Véronique Préat Gaëlle Vandermeulen

Mol Ther 2014 Apr 5;22(4):734-42. Epub 2013 Dec 5.

Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Université catholique de Louvain, Brussels, Belgium.

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April 2014

Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.

Authors:
Carole de Meester Aurélie D Timmermans Magali Balteau Audrey Ginion Véronique Roelants Gauthier Noppe Paolo E Porporato Pierre Sonveaux Benoît Viollet Kei Sakamoto Olivier Feron Sandrine Horman Jean-Louis Vanoverschelde Christophe Beauloye Luc Bertrand

Cardiovasc Res 2014 Jan 8;101(1):20-9. Epub 2013 Oct 8.

Pôle de Recherche Cardiovasculaire, Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Avenue Hippocrate, 55, B1.55.05, Brussels B-1200, Belgium.

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January 2014

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.

Authors:
Nihed Draoui Olivier Schicke Antony Fernandes Xavier Drozak Fady Nahra Amélie Dumont Jonathan Douxfils Emmanuel Hermans Jean-Michel Dogné Romu Corbau Arnaud Marchand Patrick Chaltin Pierre Sonveaux Olivier Feron Olivier Riant

Bioorg Med Chem 2013 Nov 13;21(22):7107-17. Epub 2013 Sep 13.

UCL/SSS/IREC/FATH, Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue E. Mounier 53, B1.53.09, B-1200 Brussels, Belgium; Molecules, Solids and Reactivity (MOST), Institute of Condensed Matter and Nanosciences (IMCN), UCLouvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium.

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November 2013

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

Authors:
Kelly M Kennedy Peter M Scarbrough Anthony Ribeiro Rachel Richardson Hong Yuan Pierre Sonveaux Chelsea D Landon Jen-Tsan Chi Salvatore Pizzo Thies Schroeder Mark W Dewhirst

PLoS One 2013 12;8(9):e75154. Epub 2013 Sep 12.

Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America.

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June 2014

Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications.

Authors:
Pierre Danhier Christophe J De Saedeleer Oussama Karroum Géraldine De Preter Paolo E Porporato Bénédicte F Jordan Bernard Gallez Pierre Sonveaux

Semin Radiat Oncol 2013 Oct;23(4):262-72

Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL) Medical School, Brussels, Belgium; Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCL) Medical School, Brussels, Belgium.

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October 2013

Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

Authors:
Anne-Christine Hick Anne-Sophie Delmarcelle Mahé Bouquet Sabrina Klotz Tamara Copetti Celine Forez Patrick Van Der Smissen Pierre Sonveaux Jean-François Collet Olivier Feron Pierre J Courtoy Christophe E Pierreux

Dev Biol 2013 Sep 21;381(1):227-40. Epub 2013 May 21.

de Duve Institute, Université catholique de Louvain (UCL), B-1200 Brussels, Belgium.

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September 2013

Influence of cell detachment on the respiration rate of tumor and endothelial cells.

Authors:
Pierre Danhier Tamara Copetti Géraldine De Preter Philippe Leveque Olivier Feron Bénédicte F Jordan Pierre Sonveaux Bernard Gallez

PLoS One 2013 30;8(1):e53324. Epub 2013 Jan 30.

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Brussels, Belgium.

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September 2013

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

Authors:
Christophe J De Saedeleer Tamara Copetti Paolo E Porporato Julien Verrax Olivier Feron Pierre Sonveaux

PLoS One 2012 17;7(10):e46571. Epub 2012 Oct 17.

Pole of Pharmacology, Institut de Recherches Expérimentales et Cliniques (IREC), Université catholique de Louvain (UCL), Brussels, Belgium.

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April 2013

Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.

Authors:
Oussama Karroum Julie Kengen Pierre Danhier Julie Magat Lionel Mignion Caroline Bouzin Julien Verrax Nicolas Charette Peter Starkel Pedro Buc Calderon Pierre Sonveaux Oliver Feron Vincent Grégoire Bernard Gallez Bénédicte F Jordan

Radiother Oncol 2012 Oct 8;105(1):64-71. Epub 2012 Jun 8.

Université Catholique de Louvain, Brussels, Belgium.

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October 2012

Iodine-deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a vascular endothelial growth factor-hypoxia inducible factor-1-dependent, but not a reactive oxygen species-dependent, pathway.

Authors:
Anne-Catherine Gérard Kevin Humblet Cindy Wilvers Sylvie Poncin Hanane Derradji Christine de Ville de Goyet Khalil Abou-el-Ardat Sarah Baatout Pierre Sonveaux Jean-François Denef Ides M Colin

Thyroid 2012 Jul 4;22(7):699-708. Epub 2012 Jun 4.

Department of Morphology, Institute of Experimental and Clinical Research, Catholic University of Louvain, Brussels, Belgium.

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July 2012

Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.

Authors:
Bénédicte F Jordan Pierre Sonveaux

Front Pharmacol 2012 21;3:94. Epub 2012 May 21.

Nuclear Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain Medical School Brussels, Belgium.

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October 2012

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.

Authors:
Paolo E Porporato Valéry L Payen Christophe J De Saedeleer Véronique Préat Jean-Paul Thissen Olivier Feron Pierre Sonveaux

Angiogenesis 2012 Dec 3;15(4):581-92. Epub 2012 Jun 3.

Pole of Pharmacology, Université catholique de Louvain (UCL), Avenue Emmanuel Mounier 53 box B1.53.09, 1200, Brussels, Belgium.

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December 2012

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Authors:
Pierre Sonveaux Tamara Copetti Christophe J De Saedeleer Frédérique Végran Julien Verrax Kelly M Kennedy Eui Jung Moon Suveera Dhup Pierre Danhier Françoise Frérart Bernard Gallez Anthony Ribeiro Carine Michiels Mark W Dewhirst Olivier Feron

PLoS One 2012 13;7(3):e33418. Epub 2012 Mar 13.

Pole of Pharmacology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.

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August 2012

Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

Authors:
Suveera Dhup Rajesh Kumar Dadhich Paolo Ettore Porporato Pierre Sonveaux

Curr Pharm Des 2012 ;18(10):1319-30

Pole of Pharmacology, Institute of Experimental and Clinical Research-IREC, Université Catholique de Louvain-UCL Medical School, Brussels, Belgium.

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July 2012

Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

Authors:
Romain Boidot Frédérique Végran Aline Meulle Aude Le Breton Chantal Dessy Pierre Sonveaux Sarab Lizard-Nacol Olivier Feron

Cancer Res 2012 Feb 19;72(4):939-48. Epub 2011 Dec 19.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Pharmacology, Angiogenesis and Cancer Research Laboratory, Brussels, Belgium.

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February 2012

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

Authors:
Paolo E Porporato Suveera Dhup Rajesh K Dadhich Tamara Copetti Pierre Sonveaux

Front Pharmacol 2011 25;2:49. Epub 2011 Aug 25.

Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, University of Louvain Medical School Brussels, Belgium.

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November 2011

Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging.

Authors:
Quentin Godechal Florence Defresne Pierre Danhier Philippe Leveque Paolo Ettore Porporato Pierre Sonveaux Jean-François Baurain Olivier Feron Bernard Gallez

Contrast Media Mol Imaging 2011 Jul-Aug;6(4):282-8

Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université Catholique de Louvain, Avenue Mounier 73, B-1200 Brussels, Belgium.

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January 2012

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.

Authors:
Frédérique Végran Romain Boidot Carine Michiels Pierre Sonveaux Olivier Feron

Cancer Res 2011 Apr 7;71(7):2550-60. Epub 2011 Feb 7.

Université catholique de Louvain, Pole of Pharmacology & Therapeutics (UCL-FATH), Angiogenesis & Cancer Research Laboratory, Institute of Experimental and Clinical Research (IREC), Brussels, Belgium.

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April 2011

Loss of CC3/TIP30 allows tumor cells to cope with low glucose.

Authors:
Pierre Sonveaux

Cell Cycle 2011 Feb 1;10(3):376. Epub 2011 Feb 1.

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February 2011

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.

Authors:
Eui Jung Moon Pierre Sonveaux Paolo E Porporato Pierre Danhier Bernard Gallez Ines Batinic-Haberle Yu-Chih Nien Thies Schroeder Mark W Dewhirst

Proc Natl Acad Sci U S A 2010 Nov 8;107(47):20477-82. Epub 2010 Nov 8.

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

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November 2010

Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing.

Authors:
Heng Jiang Mark De Ridder Valeri N Verovski Pierre Sonveaux Bénédicte F Jordan Kalun Law Christinne Monsaert Dirk L Van den Berge Dirk Verellen Olivier Feron Bernard Gallez Guy A Storme

Int J Radiat Oncol Biol Phys 2010 Apr;76(5):1520-7

Vrije Universiteit Brussel, Cancer Research Unit, Brussels, Belgium.

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April 2010

[Cancer: when recycling becomes a weakness].

Authors:
Pierre Sonveaux Frédérique Végran Julien Verrax Christophe J De Saedeleer Caroline Diepart Bénédicte F Jordan Bernard Gallez Olivier Feron

Med Sci (Paris) 2009 Apr;25(4):327-9

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April 2009

Nitric oxide delivery to cancer: why and how?

Authors:
Pierre Sonveaux Bénédicte F Jordan Bernard Gallez Olivier Feron

Eur J Cancer 2009 May 17;45(8):1352-69. Epub 2009 Jan 17.

Unit of Pharmacology and Therapeutics, Université catholique de Louvain (UCL), Avenue E. Mounier 52, B-1200 Brussels, Belgium.

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May 2009

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

Authors:
Pierre Sonveaux Frédérique Végran Thies Schroeder Melanie C Wergin Julien Verrax Zahid N Rabbani Christophe J De Saedeleer Kelly M Kennedy Caroline Diepart Bénédicte F Jordan Michael J Kelley Bernard Gallez Miriam L Wahl Olivier Feron Mark W Dewhirst

J Clin Invest 2008 Dec 20;118(12):3930-42. Epub 2008 Nov 20.

Unit of Pharmacology & Therapeutics, Université catholique de Louvain, Brussels, Belgium.

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December 2008

The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy.

Authors:
Françoise Frérart Pierre Sonveaux Géraldine Rath Alexandra Smoos Ahlam Meqor Nicolas Charlier Bénédicte F Jordan Julie Saliez Agnès Noël Chantal Dessy Bernard Gallez Olivier Feron

Clin Cancer Res 2008 May;14(9):2768-74

Unit of Pharmacology and Therapeutics, Université catholique de Louvain, UCL-FATH, Brussels, Belgium.

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May 2008

Provascular strategy: targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment.

Authors:
Pierre Sonveaux

Radiother Oncol 2008 Mar 3;86(3):300-13. Epub 2008 Mar 3.

Unit of Pharmacology & Therapeutics, Université catholique de Louvain (UCL), Brussels, Belgium.

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March 2008

Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid.

Authors:
Anne-Catherine Gérard Sylvie Poncin Bertrand Caetano Pierre Sonveaux Jean-Nicolas Audinot Olivier Feron Ides M Colin Fabrice Soncin

Am J Pathol 2008 Mar 14;172(3):748-60. Epub 2008 Feb 14.

CNRS UMR8161, Institut de Biologie de Lille, 1, rue Calmette, 59021 Lille Cedex, France.

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March 2008

Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment.

Authors:
Julie Dewever Françoise Frérart Caroline Bouzin Christine Baudelet Réginald Ansiaux Pierre Sonveaux Bernard Gallez Chantal Dessy Olivier Feron

Am J Pathol 2007 Nov 4;171(5):1619-28. Epub 2007 Oct 4.

Unit of Pharmacology and Therapeutics (UCL-FATH 5349), Université catholique de Louvain, Brussels, Belgium.

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November 2007

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.

Authors:
Yiting Cao Pierre Sonveaux Shanling Liu Yulin Zhao Jing Mi Bryan M Clary Chuan-Yuan Li Christopher D Kontos Mark W Dewhirst

Cancer Res 2007 Apr;67(8):3835-44

Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA.

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April 2007

Regulation of HIF-1alpha stability through S-nitrosylation.

Authors:
Fang Li Pierre Sonveaux Zahid N Rabbani Shanling Liu Bin Yan Qian Huang Zeljko Vujaskovic Mark W Dewhirst Chuan-Yuan Li

Mol Cell 2007 Apr;26(1):63-74

Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.

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April 2007

Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.

Authors:
Pierre Sonveaux Irina I Lobysheva Olivier Feron Timothy J McMahon

Physiology (Bethesda) 2007 Apr;22:97-112

Université Catholique de Louvain (UCL), Unit of Pharmacology & Therapeutics, Brussels, Belgium.

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April 2007

Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature.

Authors:
Pierre Sonveaux Françoise Frérart Caroline Bouzin Agnès Brouet Julie Dewever Bénédicte F Jordan Bernard Gallez Olivier Feron

Int J Radiat Oncol Biol Phys 2007 Mar 2;67(4):1155-62. Epub 2007 Feb 2.

Unit of Pharmacology and Therapeutics, Université Catholique de Louvain Medical School, Brussels, Belgium.

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March 2007