Publications by authors named "Pierre Maechler"

92Publications

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress.

Biomolecules 2020 Nov 12;10(11). Epub 2020 Nov 12.

Department of Cell Physiology and Metabolism & Faculty Diabetes Center, University of Geneva Medical Center, 1206 Geneva, Switzerland.

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November 2020

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.

Int J Mol Sci 2020 Jun 1;21(11). Epub 2020 Jun 1.

Department of Cell Physiology and Metabolism & Faculty Diabetes Center, University of Geneva Medical Center,1206 Geneva, Switzerland.

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June 2020

AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics.

Glia 2020 Sep 24;68(9):1824-1839. Epub 2020 Feb 24.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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September 2020

Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling.

Biochim Biophys Acta Mol Cell Res 2020 02 7;1867(2):118619. Epub 2019 Dec 7.

Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1211 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1211 Geneva, Switzerland. Electronic address:

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February 2020

Reply to Mishra: Prohibitin heterodimers-a complex time dependence for carcinogenesis.

J Biol Chem 2019 10;294(40):14837

Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland

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October 2019

Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset.

Diabetes 2019 12 19;68(12):2272-2286. Epub 2019 Sep 19.

Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Geneva, Switzerland

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December 2019

stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way.

J Biol Chem 2019 08 8;294(34):12581-12598. Epub 2019 Jul 8.

Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1206 Geneva, Switzerland

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August 2019

Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling.

Am J Physiol Endocrinol Metab 2019 07 26;317(1):E25-E41. Epub 2019 Mar 26.

Department of Cell Physiology and Metabolism, University of Geneva Medical Center , Geneva , Switzerland.

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July 2019

[Exposure of beta-cells to chronic fructose potentiates glucose-stimulated insulin secretion through ATP signaling].

Rev Med Suisse 2019 Feb;15(638):390-392

Département de physiologie cellulaire et métabolisme et Centre facultaire du diabète, Université de Genève, CMU, 1211 Genève 4.

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February 2019

Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion.

Pflugers Arch 2019 02 11;471(2):337-345. Epub 2018 Oct 11.

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva Medical Centre, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland.

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February 2019

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.

Diabetes 2018 10 12;67(10):1949-1961. Epub 2018 Jul 12.

Department of Cell Physiology and Metabolism, University of Geneva Medical School, Geneva, Switzerland

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October 2018

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.

Redox Biol 2017 10 21;13:541-549. Epub 2017 Jul 21.

Department of Cell Physiology and Metabolism & Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland. Electronic address:

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October 2017

Glutamate pathways of the beta-cell and the control of insulin secretion.

Authors:
Pierre Maechler

Diabetes Res Clin Pract 2017 Sep 12;131:149-153. Epub 2017 Jul 12.

Department of Cell Physiology and Metabolism & Faculty Diabetes Center, University of Geneva Medical Center, Geneva, Switzerland. Electronic address:

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September 2017

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression.

Diabetes 2017 10 7;66(10):2541-2554. Epub 2017 Jul 7.

Division of Bone Diseases, Department of Internal Medicine Specialties, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland

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October 2017