Publications by authors named "Pierre Desreumaux"

100Publications

GED-0507 is a novel potential antifibrotic treatment option for pulmonary fibrosis.

Cell Mol Immunol 2020 Dec 12;17(12):1272-1274. Epub 2020 Mar 12.

Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

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December 2020

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.

Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.

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April 2019

Treatments for Crohn's Disease-Associated Bowel Damage: A Systematic Review.

Clin Gastroenterol Hepatol 2019 04 23;17(5):847-856. Epub 2018 Aug 23.

Translational Gastroenterology Research Unit, GIGA-R, University of Liège, Liège, Belgium; Hepato-Gastroenterology and Digestive Oncology Unit, University Hospital, CHU Liège, Belgium.

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April 2019

High carriage of adherent invasive in wildlife and healthy individuals.

Gut Pathog 2018 14;10:23. Epub 2018 Jun 14.

Lille Inflammation Research International Center, UMR 995 Inserm, Lille University, CHRU Lille, Lille, France.

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June 2018

Patients with Crohn's Disease with High Body Mass Index Present More Frequent and Rapid Loss of Response to Infliximab.

Inflamm Bowel Dis 2017 10;23(10):1853-1859

*CHU Lille, Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Lille, France; †CHU Lille, Dermatology Department, Claude Huriez Hospital, University of Lille 2, Lille, France; and ‡CHU Lille, Pharmacy Department, Claude Huriez Hospital, University of Lille 2, Lille, France.

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October 2017

CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis.

World J Gastroenterol 2017 Jan;23(2):336-344

Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.

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January 2017

[Enteric microflora in inflammatory bowel disease patients].

Med Sci (Paris) 2016 Nov 23;32(11):968-973. Epub 2016 Dec 23.

LIRIC UMR 995 Inserm ; université de Lille ; CHRU de Lille, faculté de médecine, Place de Verdun, F-59045, Lille Cedex, France.

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November 2016

Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.

N Engl J Med 2016 11;375(20):1946-1960

From Robarts Clinical Trials, Robarts Research Institute, Western University, London, ON (B.G.F.), University of Calgary, Calgary, AB (S.G.), and the Division of Gastroenterology and CEGIIR, University of Alberta, Edmonton (L.A.D.) - all in Canada; University of California, San Diego, La Jolla (W.J.S.), and Cedars-Sinai Medical Center, Los Angeles (S.T.) - both in California; Janssen Research and Development, Spring House (C.G., D.J., Y.L., J.R.F., J.J., L.-L.G., Y.M., O.J.A.), and Janssen Scientific Affairs, Horsham (M.A.B.) - both in Pennsylvania; the Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai (B.E.S., J.-F.C.), and New York University School of Medicine (S.K.) - both in New York; Feinberg School of Medicine, Northwestern University, Chicago (S.B.H.); University Hospitals Leuven, Leuven, Belgium (S.V., P.R.); Stellenbosch University, Stellenbosch, South Africa (W.J.V.); Semmelweis University of Budapest, Budapest, Hungary (Z.T.); the Department of Gastroenterology, Hannover Medical School, Hannover, Germany (U.S.); Atlanta Gastroenterology Specialists, Atlanta (B.A.S.); Hôpital Claude Huriez, Lille, France (P.D.); University of Washington Medical Center, Seattle (S.D.L.); and the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN (E.V.L.).

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November 2016

Adalimumab dose escalation is effective and well tolerated in Crohn's disease patients with secondary loss of response to adalimumab.

Dig Liver Dis 2017 Feb 14;49(2):163-169. Epub 2016 Nov 14.

Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Lille, France. Electronic address:

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February 2017

Probiotic Yeast Therapy for Irritable Bowel Syndrome.

J Neurogastroenterol Motil 2016 Jul;22(3):542

CHU Lille, Department of Gastroenterology, Claude Huriez Hospital, Lille, France.

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July 2016

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis.

Inflamm Bowel Dis 2016 Feb;22(2):279-92

*Inserm, LIRIC UMR995, Lille, France; †CHRU de Lille, Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Claude Huriez, LIRIC, UMR995, Lille, France; ‡Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, L'Aquila, Italy; §IBD, Lille, France; ‖Department of Pathobiology, Lerner Research Institute, and Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio; ¶Université Lille Nord de France, Lille, France; and **Department of Human Anatomy, University of Roma "La Sapienza," Roma, Italy.

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February 2016

Acrylamide induces accelerated endothelial aging in a human cell model.

Food Chem Toxicol 2015 Sep 10;83:140-5. Epub 2015 Jun 10.

Inserm U995/Team "Glycation: From Inflammation to Aging", Lille School of Medicine, Lille University, France. Electronic address:

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September 2015

Eosinophilic enteritis.

Dig Dis 2015 22;33(2):183-9. Epub 2015 Apr 22.

Clinique des maladies de l'appareil digestif et de la nutrition, Hôpital Claude Huriez, Lille, France.

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January 2016

Author's reply to Comment on "A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome" by Guillaume Pineton de Chambrun et al. [Digestive and Liver Disease 2015;47:119-24].

Dig Liver Dis 2015 May 3;47(5):437-8. Epub 2015 Feb 3.

CHU Lille, Department of Gastroenterology, Claude Huriez Hospital, Lille, France; Lille University North of France, Lille, France; INSERM U995, Lille, France. Electronic address:

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May 2015

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

ACS Med Chem Lett 2015 Feb 4;6(2):198-203. Epub 2014 Dec 4.

Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille Nord de France , E.A 4481, IFR 114, 3 rue du Pr. Laguesse, B.P. 83, F-59006 Lille Cedex, France.

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February 2015

Intestinal steroidogenesis.

Steroids 2015 Nov 2;103:64-71. Epub 2015 Jan 2.

Université de Lille, F-59000 Lille, France; Inserm U995, F-59045 Lille, France; Faculté des Sciences Pharmaceutiques et Biologiques, F-59006 Lille, France. Electronic address:

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November 2015

A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome.

Dig Liver Dis 2015 Feb 13;47(2):119-24. Epub 2014 Nov 13.

CHU Lille, Department of Gastroenterology, Claude Huriez Hospital, Lille, France; Lille University North of France, Lille, France; INSERM U995, Lille, France. Electronic address:

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February 2015

Peroxisome proliferator-activated receptor gamma in the colon: inflammation and innate antimicrobial immunity.

J Clin Gastroenterol 2014 Nov-Dec;48 Suppl 1:S23-7

*INSERM U995 †Université Lille Nord de France ‡CHU Lille, Service des maladies de l'appareil digestif et de la nutrition, Hôpital Claude Huriez, Lille, France.

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June 2015

Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis.

Gut 2015 Jun 22;64(6):901-10. Epub 2014 Jul 22.

Université Lille Nord de France, Lille, France Inserm U995, Lille, France UDSL, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.

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June 2015

Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.

Am J Physiol Gastrointest Liver Physiol 2014 Aug 29;307(3):G274-85. Epub 2014 May 29.

INSERM U995, Lille, France; Université Lille Nord de France, Lille, France; CHU Lille, Service des maladies de l'appareil digestif et de la nutrition, Hôpital Claude Huriez, Lille, France;

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August 2014

Therapeutical potential of CB₂ receptors in immune-related diseases.

Curr Mol Pharmacol 2013 Nov;6(3):183-203

Universite du Droit et de la Sante de Lille, EA 4481, Institut de Chimie Pharmaceutique Albert Lespagnol, 3 rue du Pr. Laguesse, B.P. 83, F-59006 Lille, France.

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November 2013

Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.

Bioorg Med Chem Lett 2014 Mar 28;24(5):1322-6. Epub 2014 Jan 28.

Université Lille Nord de France, EA4481, Institut de Chimie Pharmaceutique Albert Lespagnol, IFR114, 3 rue du Pr. Laguesse, BP83, F-59006 Lille, France. Electronic address:

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March 2014

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

J Med Chem 2014 Jul 12;57(13):5489-508. Epub 2014 Feb 12.

Faculté de Médecine, Intestinal Biotech Development, Amphis J et K, Boulevard du Professeur Jules Leclerc, 59045 Lille Cedex, France.

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July 2014

Preclinical studies of a specific PPARγ modulator in the control of skin inflammation.

J Invest Dermatol 2014 Apr 28;134(4):1001-1011. Epub 2013 Oct 28.

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy. Electronic address:

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April 2014

Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases.

Inflamm Bowel Dis 2013 Oct;19(11):2315-25

1Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, Marseille, France; 2Institut National de la Santé et de la Recherche Médicale (Inserm), U1104, Marseille, France; 3Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France; 4Inserm, UMR_S1090, TAGC, Marseille, France; 5Aix-Marseille University, Marseille, France; 6Oncogenetic Laboratory, Institut Paoli Calmettes, Marseille, France; 7Université Lille Nord de France, Lille, France; 8Inserm U995, Lille, France; 9CHU Lille, Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Claude, Huriez, Lille, France; 10UDSL, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France; 11Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; 12Inserm U1080, IRCAN Team 3, Nice, France; 13Université de Nice Sophia Antipolis, Nice, France; and 14Human Tissue Biobank Centre de Ressources Biologiques INSERM, Pasteur Hospital, Nice, France.

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October 2013

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

Bioorg Med Chem 2013 Sep 15;21(17):5383-94. Epub 2013 Jun 15.

Université Lille Nord de France, EA4481, Institut de Chimie Pharmaceutique Albert Lespagnol, IFR114, 3 Rue du Pr. Laguesse, BP83, F-59006 Lille, France.

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September 2013

PPAR-gamma in ulcerative colitis: a novel target for intervention.

Curr Drug Targets 2013 Nov;14(12):1501-7

Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

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November 2013

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

Chem Biol Drug Des 2013 Apr;81(4):442-54

Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université Lille-Nord de France, EA 4481, 3 rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France.

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April 2013

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation.

Cell Biosci 2012 Oct 10;2(1):34. Epub 2012 Oct 10.

Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Genopode Building, 1015, Lausanne, Switzerland.

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October 2012

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

J Med Chem 2012 May 27;55(9):4027-61. Epub 2012 Feb 27.

Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université Lille-Nord de France, EA 4481, 3 Rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France.

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May 2012

Visceral fat and gut inflammation.

Nutrition 2012 Feb;28(2):113-7

Université Lille Nord de France, Lille, France.

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February 2012

Natural history of eosinophilic gastroenteritis.

Clin Gastroenterol Hepatol 2011 Nov 30;9(11):950-956.e1. Epub 2011 Jul 30.

Univ Lille Nord de France, F-59000, Lille, France.

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November 2011

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.

Bioorg Med Chem 2011 Jun 6;19(12):3777-86. Epub 2011 May 6.

Université Lille Nord de France, ICPAL, EA 4481, IFR114, 3 rue du Professeur Laguesse, BP-83, F-59006 Lille, France.

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June 2011

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series.

J Med Chem 2010 Nov 27;53(22):7918-31. Epub 2010 Oct 27.

Université Lille-Nord de France, Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, IFR 114, 3 Rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France.

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November 2010

Obesity, visceral fat and Crohn's disease.

Curr Opin Clin Nutr Metab Care 2010 Sep;13(5):574-80

Université Lille Nord de France, France.

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September 2010

Novel polymeric film coatings for colon targeting: Drug release from coated pellets.

Eur J Pharm Sci 2009 Jun 5;37(3-4):427-33. Epub 2009 Apr 5.

College of Pharmacy, JE 2491, Universite Lille Nord de France, 3 rue du Professeur Laguesse, 59006 Lille, France.

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June 2009

Colon targeting with bacteria-sensitive films adapted to the disease state.

Eur J Pharm Biopharm 2009 Sep 4;73(1):74-81. Epub 2009 May 4.

College of Pharmacy, Lille Northern University of France, Lille, France.

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September 2009

Novel polymeric film coatings for colon targeting: how to adjust desired membrane properties.

Int J Pharm 2009 Apr 24;371(1-2):64-70. Epub 2008 Dec 24.

College of Pharmacy, JE 2491, University of Lille, 3 rue du Professeur Laguesse, 59006 Lille, France.

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April 2009

PPARgamma agonists as a new class of effective treatment for ulcerative colitis.

Inflamm Bowel Dis 2009 Jun;15(6):959-60

University of Lille 2, Huriez Hospital, Digestive Tract Diseases and Nutrition Department, Lille, France.

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June 2009

Crohn's disease: beyond antagonists of tumour necrosis factor.

Lancet 2008 Jul;372(9632):67-81

Hôpital Claude Huriez, Centre Hospitalier Universitaire de Lille, Lille, France.

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July 2008

Understanding the Mechanism of 5-ASA in Treating Colonic Inflammation.

Gastroenterol Hepatol (N Y) 2008 May;4(5):319-20

Professor of Gastroenterology Department of Hepatogastroenterology and Nutrition Director of Research in Inflammatory Digestive Diseases University of Lille, France.

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May 2008

Colonization of mice by Candida albicans is promoted by chemically induced colitis and augments inflammatory responses through galectin-3.

J Infect Dis 2008 Apr;197(7):972-80

Inserm U 799, Physiopathologie des Candidoses, Faculté de Médecine, Centre Hospitalier Régional Universitaire de Lille, Institut Fédératif de Recherche 114, Université Lille 2, , Lille, France.

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April 2008

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

Proc Natl Acad Sci U S A 2007 Aug 1;104(32):13098-103. Epub 2007 Aug 1.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, Illkirch, and Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Huriez, Lille, France.

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August 2007

How NOD2 mutations predispose to Crohn's disease?

Microbes Infect 2007 Apr 27;9(5):658-63. Epub 2007 Jan 27.

INSERM, U 795, Lille, F-59037 France.

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April 2007

Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.

Am J Gastroenterol 2007 May 13;102(5):1108-15. Epub 2007 Mar 13.

Inserm, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy-Universitè Vandoeuvre-les-Nancy, F-54511, France.

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May 2007

micro-Opioid receptor activation prevents acute hepatic inflammation and cell death.

Gut 2007 Jul 13;56(7):974-81. Epub 2007 Feb 13.

Institut National de la Santé et de la Recherche Médicale (INSERM) U795, University of Lille 2, Digestive Tract Diseases and Nutrition Department, 59037, Lille Cedex, France.

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July 2007

Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro.

Cell Microbiol 2007 May 11;9(5):1252-61. Epub 2007 Jan 11.

Department Molecular Mechanisms of Mycobacterial Infections, IPBS, CNRS UMR5089, Toulouse 31077, France.

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May 2007

[The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)].

J Soc Biol 2006 ;200(2):121-31

Laboratoire de Physiopathologie des Maladies Inflammatoires Intestinales, INSERM E114, Hôpital Huriez, Service de Gastroentérologie, 1, place de Verdun, 59000 Lille.

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April 2007

NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.

Trends Microbiol 2006 Oct 30;14(10):432-8. Epub 2006 Aug 30.

INSERM U795, University of Lille 2, Huriez Hospital, Digestive Tract Diseases and Nutrition Department, F-59037 Lille, France.

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October 2006

[Fluorescent imaging in digestive endoscopy].

Gastroenterol Clin Biol 2006 Jan;30(1):165-8

EA 2689 INSERM IFR 114, Pavillon Vancostenobel, CHRU, 59037 Lille Cedex.

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January 2006

[Narrow band image videoendoscopy in gastroterology].

Gastroenterol Clin Biol 2005 Nov;29(11):1190-2

EA 2689 INSERM IFR 114, Pavilion Vancostenobel, Service des Maladies de l'Appareil Digestif et de la Nutrition, CHRU Lille.

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November 2005

Advances and perspectives in the genetics of inflammatory bowel diseases.

Clin Gastroenterol Hepatol 2006 Feb;4(2):143-51

INSERM 0114, Hôpital Swynghedauw, Rue A. Verhaeghe, F-59037 Lille, France.

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February 2006

[NOD2/CARD15 and Crohn's disease].

Gastroenterol Clin Biol 2005 Jun-Jul;29(6-7):696-700

Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Huriez, 59037 Lille Cedex, France.

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October 2005