Publications by authors named "Pierpaolo Ceci"

35 Publications

High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors.

Authors:
Elisabetta Falvo Verena Damiani Giamaica Conti Federico Boschi Katia Messana Patrizio Giacomini Michele Milella Vincenzo De Laurenzi Veronica Morea Gianluca Sala Giulio Fracasso Pierpaolo Ceci

J Exp Clin Cancer Res 2021 Feb 10;40(1):63. Epub 2021 Feb 10.

CNR - National Research Council of Italy, Institute of Molecular Biology and Pathology, Rome, Italy.

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February 2021

Engineered Human Nanoferritin Bearing the Drug Genz-644282 for Cancer Therapy.

Authors:
Elisabetta Falvo Alessandro Arcovito Giamaica Conti Giuseppe Cipolla Martina Pitea Veronica Morea Verena Damiani Gianluca Sala Giulio Fracasso Pierpaolo Ceci

Pharmaceutics 2020 Oct 20;12(10). Epub 2020 Oct 20.

CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology, 00185 Rome, Italy.

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October 2020

Increasing the Magnetic Anisotropy of a Natural System: Co-Doped Magnetite Mineralized in Ferritin Shells.

Authors:
Elvira Fantechi Claudia Innocenti Anna Maria Ferretti Elisabetta Falvo Pierpaolo Ceci Francesco Pineider Claudio Sangregorio

J Nanosci Nanotechnol 2019 Aug;19(8):4964-4973

Istituto di Chimica dei Composti Organo-Metallici, Consiglio Nazionale delle Ricerche, via Madonna del Piano 10, I-50019 Sesto Fiorentino, Italy.

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August 2019

Cryo-EM structure of the human ferritin-transferrin receptor 1 complex.

Authors:
Linda Celeste Montemiglio Claudia Testi Pierpaolo Ceci Elisabetta Falvo Martina Pitea Carmelinda Savino Alessandro Arcovito Giovanna Peruzzi Paola Baiocco Filippo Mancia Alberto Boffi Amédée des Georges Beatrice Vallone

Nat Commun 2019 03 8;10(1):1121. Epub 2019 Mar 8.

Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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March 2019

Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells.

Authors:
Rossella Loria Claudia Giliberti Angelico Bedini Raffaele Palomba Giulio Caracciolo Pierpaolo Ceci Elisabetta Falvo Raffaella Marconi Rita Falcioni Gianluca Bossi Lidia Strigari

J Exp Clin Cancer Res 2019 Jan 3;38(1). Epub 2019 Jan 3.

Laboratory of Medical Physics and Expert Systems, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.

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January 2019

The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity.

Authors:
Elisabetta Falvo Francesca Malagrinò Alessandro Arcovito Francesco Fazi Gianni Colotti Elisa Tremante Patrizio Di Micco Aldo Braca Roberta Opri Alessandro Giuffrè Giulio Fracasso Pierpaolo Ceci

J Control Release 2018 04 20;275:177-185. Epub 2018 Feb 20.

Institute of Molecular Biology and Pathology, CNR - National Research Council of Italy, 00185 Rome, Italy. Electronic address:

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April 2018

Therapeutic Efficacy of the Novel Stimuli-Sensitive Nano-Ferritins Containing Doxorubicin in a Head and Neck Cancer Model.

Authors:
Verena Damiani Elisabetta Falvo Giulio Fracasso Luca Federici Martina Pitea Vincenzo De Laurenzi Gianluca Sala Pierpaolo Ceci

Int J Mol Sci 2017 Jul 18;18(7). Epub 2017 Jul 18.

Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR), Rome 00185, Italy.

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July 2017

Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.

Authors:
Giulio Fracasso Elisabetta Falvo Gianni Colotti Francesco Fazi Tiziano Ingegnere Adriana Amalfitano Giovanni Battista Doglietto Sergio Alfieri Alberto Boffi Veronica Morea Giamaica Conti Elisa Tremante Patrizio Giacomini Alessandro Arcovito Pierpaolo Ceci

J Control Release 2016 10 12;239:10-8. Epub 2016 Aug 12.

Institute of Molecular Biology and Pathology, CNR - National Research Council of Italy, 00185 Rome, Italy. Electronic address:

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October 2016

Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements.

Authors:
Elisabetta Falvo Elisa Tremante Alessandro Arcovito Massimiliano Papi Nadav Elad Alberto Boffi Veronica Morea Giamaica Conti Giuseppe Toffoli Giulio Fracasso Patrizio Giacomini Pierpaolo Ceci

Biomacromolecules 2016 Feb 30;17(2):514-22. Epub 2015 Dec 30.

Institute of Molecular Biology and Pathology CNR, National Research Council of Italy , 00185 Rome, Italy.

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February 2016

In Vivo Targeting of Cutaneous Melanoma Using an Melanoma Stimulating Hormone-Engineered Human Protein Cage with Fluorophore and Magnetic Resonance Imaging Tracers.

Authors:
Luca Vannucci Elisabetta Falvo Cristina Maria Failla Miriam Carbo Manuela Fornara Rossella Canese Serena Cecchetti Lenka Rajsiglova Dmitry Stakheev Jiri Krizan Alberto Boffi Giulia Carpinelli Veronica Morea Pierpaolo Ceci

J Biomed Nanotechnol 2015 Jan;11(1):81-92

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January 2015

A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages.

Authors:
Elvira Fantechi Claudia Innocenti Matteo Zanardelli Maria Fittipaldi Elisabetta Falvo Miriam Carbo Valbona Shullani Lorenzo Di Cesare Mannelli Carla Ghelardini Anna Maria Ferretti Alessandro Ponti Claudio Sangregorio Pierpaolo Ceci

ACS Nano 2014 May 8;8(5):4705-19. Epub 2014 Apr 8.

INSTM and Dipartimento di Chimica "U. Schiff", Università degli Studi di Firenze , via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy.

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May 2014

Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin.

Authors:
Elisabetta Falvo Elisa Tremante Rocco Fraioli Carlo Leonetti Carlotta Zamparelli Alberto Boffi Veronica Morea Pierpaolo Ceci Patrizio Giacomini

Nanoscale 2013 Dec;5(24):12278-85

CNR - National Research Council of Italy, Institute of Molecular Biology and Pathology, Rome, Italy.

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December 2013

Electrostatic assembly of binary nanoparticle superlattices using protein cages.

Authors:
Mauri A Kostiainen Panu Hiekkataipale Ari Laiho Vincent Lemieux Jani Seitsonen Janne Ruokolainen Pierpaolo Ceci

Nat Nanotechnol 2013 Jan 16;8(1):52-6. Epub 2012 Dec 16.

Molecular Materials, Department of Applied Physics, Aalto University, 00076 Espoo, Finland.

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January 2013

Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles.

Authors:
Luca Vannucci Elisabetta Falvo Manuela Fornara Patrizio Di Micco Oldrich Benada Jiri Krizan Jan Svoboda Katarina Hulikova-Capkova Veronica Morea Alberto Boffi Pierpaolo Ceci

Int J Nanomedicine 2012 16;7:1489-509. Epub 2012 Mar 16.

Institute of Microbiology, Academy of Sciences of the Czech Republic, VVI, Prague, Czech Republic.

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September 2012

Hierarchical self-assembly and optical disassembly for controlled switching of magnetoferritin nanoparticle magnetism.

Authors:
Mauri A Kostiainen Pierpaolo Ceci Manuela Fornara Panu Hiekkataipale Oksana Kasyutich Roeland J M Nolte Jeroen J L M Cornelissen Ryan D Desautels Johan van Lierop

ACS Nano 2011 Aug 15;5(8):6394-402. Epub 2011 Jul 15.

Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

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August 2011

Effect of the charge distribution along the "ferritin-like" pores of the proteins from the Dps family on the iron incorporation process.

Authors:
Pierpaolo Ceci Gisa Di Cecca Mattia Falconi Francesco Oteri Carlotta Zamparelli Emilia Chiancone

J Biol Inorg Chem 2011 Aug 6;16(6):869-80. Epub 2011 May 6.

Department of Biochemical Sciences, CNR Institute of Molecular Biology and Pathology, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy.

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August 2011

The characterization of Thermotoga maritima ferritin reveals an unusual subunit dissociation behavior and efficient DNA protection from iron-mediated oxidative stress.

Authors:
Pierpaolo Ceci Elena Forte Gisa Di Cecca Manuela Fornara Emilia Chiancone

Extremophiles 2011 May 13;15(3):431-9. Epub 2011 Apr 13.

Institute of Molecular Biology & Pathology, CNR, Rome, Italy.

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May 2011

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation.

Authors:
Paola Baiocco Andrea Ilari Pierpaolo Ceci Stefania Orsini Marina Gramiccia Trentina Di Muccio Gianni Colotti

ACS Med Chem Lett 2011 Mar 29;2(3):230-3. Epub 2010 Dec 29.

Institute of Molecular Biology and Pathology CNR, and Department of Biochemical Sciences, Sapienza University of Roma , P.le A. Moro 5, 00185 Rome, Italy.

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March 2011

Silver ion incorporation and nanoparticle formation inside the cavity of Pyrococcus furiosus ferritin: structural and size-distribution analyses.

Authors:
Oksana Kasyutich Andrea Ilari Annarita Fiorillo Dragomir Tatchev Armin Hoell Pierpaolo Ceci

J Am Chem Soc 2010 Mar;132(10):3621-7

University of Bristol, Physics Department, HH Wills Physics Laboratory, Tyndall Avenues, Bristol, BS8 1TL, UK.

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March 2010

The multifaceted capacity of Dps proteins to combat bacterial stress conditions: Detoxification of iron and hydrogen peroxide and DNA binding.

Authors:
Emilia Chiancone Pierpaolo Ceci

Biochim Biophys Acta 2010 Aug 4;1800(8):798-805. Epub 2010 Feb 4.

Department of Biochemical Sciences 'A. Rossi Fanelli', "Sapienza" University of Rome, Rome, Italy.

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August 2010

Thermosynechococcus elongatus DpsA binds Zn(II) at a unique three histidine-containing ferroxidase center and utilizes O2 as iron oxidant with very high efficiency, unlike the typical Dps proteins.

Authors:
Flaminia Alaleona Stefano Franceschini Pierpaolo Ceci Andrea Ilari Emilia Chiancone

FEBS J 2010 Feb 20;277(4):903-17. Epub 2010 Jan 20.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, University of Rome La Sapienza, Italy.

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February 2010

Role of Dps (DNA-binding proteins from starved cells) aggregation on DNA.

Authors:
Emilia Chiancone Pierpaolo Ceci

Front Biosci (Landmark Ed) 2010 Jan 1;15:122-31. Epub 2010 Jan 1.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, Sapienza, University of Rome, 00185 Rome, Italy.

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January 2010

Dps proteins prevent Fenton-mediated oxidative damage by trapping hydroxyl radicals within the protein shell.

Authors:
Giuliano Bellapadrona Matteo Ardini Pierpaolo Ceci Simonetta Stefanini Emilia Chiancone

Free Radic Biol Med 2010 Jan 3;48(2):292-7. Epub 2009 Nov 3.

CNR Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, Sapienza University of Rome, 00185 Rome, Italy.

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January 2010

Synthesis of iron oxide nanoparticles in Listeria innocua Dps (DNA-binding protein from starved cells): a study with the wild-type protein and a catalytic centre mutant.

Authors:
Pierpaolo Ceci Emilia Chiancone Oksana Kasyutich Giuliano Bellapadrona Lisa Castelli Maria Fittipaldi Dante Gatteschi Claudia Innocenti Claudio Sangregorio

Chemistry 2010 Jan;16(2):709-17

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, Sapienza, University of Rome, 00185 Rome, Italy.

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January 2010

Periplasmic Cu,Zn superoxide dismutase and cytoplasmic Dps concur in protecting Salmonella enterica serovar Typhimurium from extracellular reactive oxygen species.

Authors:
Francesca Pacello Pierpaolo Ceci Serena Ammendola Paolo Pasquali Emilia Chiancone Andrea Battistoni

Biochim Biophys Acta 2008 Feb 14;1780(2):226-32. Epub 2007 Dec 14.

Dipartimento di Biologia, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy.

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February 2008

The neutrophil-activating Dps protein of Helicobacter pylori, HP-NAP, adopts a mechanism different from Escherichia coli Dps to bind and condense DNA.

Authors:
Pierpaolo Ceci Laura Mangiarotti Claudio Rivetti Emilia Chiancone

Nucleic Acids Res 2007 19;35(7):2247-56. Epub 2007 Mar 19.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, University of Rome La Sapienza, Rome, Italy.

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June 2007

Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus.

Authors:
Stefano Franceschini Pierpaolo Ceci Flaminia Alaleona Emilia Chiancone Andrea Ilari

FEBS J 2006 Nov 3;273(21):4913-28. Epub 2006 Oct 3.

C.N.R. Institute of Molecular Biology and Pathology, University of Rome La Sapienza, Piazzale E. Moro 5, 00185 Rome, Italy.

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November 2006

Reassessment of protein stability, DNA binding, and protection of Mycobacterium smegmatis Dps.

Authors:
Pierpaolo Ceci Andrea Ilari Elisabetta Falvo Laura Giangiacomo Emilia Chiancone

J Biol Chem 2005 Oct 19;280(41):34776-85. Epub 2005 Jul 19.

National Research Council Institute of Molecular Biology and Pathology, Department of Biochemical Sciences "A. Rossi-Fanelli," University of Rome "La Sapienza," 00185 Rome, Italy.

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October 2005

The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants.

Authors:
Andrea Ilari Maria Carmela Latella Pierpaolo Ceci Federica Ribacchi Meihong Su Laura Giangiacomo Simonetta Stefanini N Dennis Chasteen Emilia Chiancone

Biochemistry 2005 Apr;44(15):5579-87

Istituto di Biologia e Patologia Molecolari CNR, Dipartimento di Scienze Biochimiche, Università La Sapienza, P.le A. Moro, 5, 00185 Roma, Italy.

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April 2005

DNA condensation and self-aggregation of Escherichia coli Dps are coupled phenomena related to the properties of the N-terminus.

Authors:
Pierpaolo Ceci Sara Cellai Elisabetta Falvo Claudio Rivetti Gian Luigi Rossi Emilia Chiancone

Nucleic Acids Res 2004 8;32(19):5935-44. Epub 2004 Nov 8.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi-Fanelli, University of Rome La Sapienza, 00185 Rome, Italy.

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December 2004