Piero Marchetti

Piero Marchetti

UNVERIFIED PROFILE

Are you Piero Marchetti?   Register this Author

Register author
Piero Marchetti

Piero Marchetti

Publications by authors named "Piero Marchetti"

Are you Piero Marchetti?   Register this Author

99Publications

3131Reads

35Profile Views

The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells.

J Mol Endocrinol 2019 Jul 1. Epub 2019 Jul 1.

D Eizirik, ULB, Center for Diabetes Research, ULB, Anderlecht, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-19-0066DOI Listing
July 2019

Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets.

Cell Metab 2019 Jun 14;29(6):1422-1432.e3. Epub 2019 Mar 14.

Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2019.02.012DOI Listing
June 2019

A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2019 02 14;62(2):209-211. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-018-4784-yDOI Listing
February 2019

A Call for Improved Reporting of Human Islet Characteristics in Research Articles.

Diabetes 2019 02 14;68(2):239-240. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/dbi18-0055DOI Listing
February 2019

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells.

J Innate Immun 2019 20;11(4):375-390. Epub 2019 Feb 20.

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738210PMC
February 2019

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Cell Metab 2018 12 2;28(6):946-960.e6. Epub 2018 Aug 2.

INSERM, U1016, Cochin Institute, 75014 Paris, France; CNRS, UMR8104, Cochin Institute, 75014 Paris, France; Paris Descartes University, Sorbonne Paris Cité, 75014 Paris, France; Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Cochin Hospital, 75014 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2018.07.007DOI Listing
December 2018

Probing the light scattering properties of insulin secretory granules in single live cells.

Biochem Biophys Res Commun 2018 09 14;503(4):2710-2714. Epub 2018 Aug 14.

NEST - Scuola Normale Superiore, Istituto Nanoscienze - CNR (CNR NANO), Pisa, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X183170
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2018.08.029DOI Listing
September 2018

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Diabetologia 2018 08 12;61(8):1780-1793. Epub 2018 May 12.

Unité Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Équipe Régulation de la glycémie par le système nerveux central, Université Paris Diderot, 4 rue Marie-Andrée-Lagroua-Weill-Hallé, 75205, Paris CEDEX 13, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-018-4629-8DOI Listing
August 2018

Duodenal graft complications requiring duodenectomy after pancreas and pancreas-kidney transplantation.

Am J Transplant 2018 06 9;18(6):1388-1396. Epub 2018 Jan 9.

Division of General and Transplant Surgery, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.14613DOI Listing
June 2018

MiR-184 expression is regulated by AMPK in pancreatic islets.

FASEB J 2018 05 8;32(5):2587-2600. Epub 2018 Jan 8.

Section of Cell Biology and Functional Genomics Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201701100RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207280PMC
May 2018

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.

Diabetologia 2018 04 21;61(4):770-774. Epub 2018 Jan 21.

Department of Clinical and Experimental Medicine and University Hospital, University of Pisa, via Paradisa 2, 56121, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-018-4546-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449064PMC
April 2018

MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s.

Int J Mol Sci 2018 Apr 12;19(4). Epub 2018 Apr 12.

Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, 53100 Siena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19041170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979342PMC
April 2018

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Diabetes 2018 Mar 28;67(3):385-399. Epub 2017 Dec 28.

Section of Cell Biology and Functional Genomics and Pancreatic Islet Biology and Diabetes Consortium, Imperial College London, London, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0639DOI Listing
March 2018

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Diabetologia 2018 03 5;61(3):636-640. Epub 2018 Jan 5.

ULB Center for Diabetes Research, Medical Faculty, Campus Erasme, Université Libre de Bruxelles, Route de Lennik, 808-CP618, B-1070, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-017-4536-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241216PMC
March 2018

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion.

Diabetes 2017 11 19;66(11):2849-2856. Epub 2017 Jul 19.

Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0002DOI Listing
November 2017

Update on pancreatic transplantation on the management of diabetes.

Minerva Med 2017 Oct 2;108(5):405-418. Epub 2017 May 2.

Division of General and Transplant Surgery, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy -

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0026-4806.17.05224-7DOI Listing
October 2017

Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus.

Diabetes Metab Res Rev 2017 09 18;33(6). Epub 2017 Apr 18.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dmrr.2894
Publisher Site
http://dx.doi.org/10.1002/dmrr.2894DOI Listing
September 2017

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

Diabetes 2017 09 30;66(9):2446-2458. Epub 2017 Jun 30.

Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db16-1252DOI Listing
September 2017

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

Biochem Pharmacol 2017 08 15;138:140-149. Epub 2017 May 15.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2017.05.007DOI Listing
August 2017

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.

Endocrinology 2017 08;158(8):2503-2521

Université Libre de Bruxelles Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2017-00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551554PMC
August 2017

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.

Endocrinology 2017 06;158(6):1659-1670

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2016-1773DOI Listing
June 2017

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes.

Front Cell Dev Biol 2017 23;5:55. Epub 2017 May 23.

Department of Clinical and Experimental Medicine, University of PisaPisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2017.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440564PMC
May 2017

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

Diabetologia 2017 04 6;60(4):656-667. Epub 2017 Jan 6.

ULB Center for Diabetes Research, Campus Erasme, Université Libre de Bruxelles, Route de Lennik, 808-CP618, B-1070, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-016-4201-3DOI Listing
April 2017

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cell Death Differ 2016 12 2;23(12):1995-2006. Epub 2016 Sep 2.

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cdd.2016.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136495PMC
December 2016

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Cell Metab 2016 09 21;24(3):389-401. Epub 2016 Jul 21.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, UK; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2016.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031557PMC
September 2016

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Diabetes 2016 04 28;65(4):1009-21. Epub 2016 Jan 28.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-1334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806657PMC
April 2016

Islet inflammation in type 2 diabetes.

Authors:
Piero Marchetti

Diabetologia 2016 Apr 19;59(4):668-72. Epub 2016 Feb 19.

Department of Clinical and Experimental Medicine, Cisanello University Hospital, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00125-016-3875-x
Publisher Site
http://dx.doi.org/10.1007/s00125-016-3875-xDOI Listing
April 2016

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes.

J Clin Endocrinol Metab 2016 Mar 29;101(3):1044-54. Epub 2015 Dec 29.

Departments of Medicine (F.C., R.B., J.Y.K.-M., D.A.) and Surgery (Y.O., P.R.S., L.E.R.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Clinical and Experimental Medicine (F.C.), Università Politecnica delle Marche, Ancona, Italy; and Department of Clinical and Experimental Medicine (M.M., L.M., M.S., P.M.), Islet Cell Laboratory, University of Pisa, 56100 Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2015-2860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803182PMC
March 2016

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.

Diabetes 2015 Nov 3;64(11):3808-17. Epub 2015 Aug 3.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-0362DOI Listing
November 2015

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

Diabetologia 2015 Nov 15;58(11):2554-62. Epub 2015 Aug 15.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-015-3734-1DOI Listing
November 2015

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Diabetologia 2015 Oct 23;58(10):2307-16. Epub 2015 Jun 23.

ULB-Center for Diabetes Research, Universitè Libre de Bruxelles (ULB), Route de Lennik, 808-CP618, 1070, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-015-3669-6DOI Listing
October 2015

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Diabetologia 2015 Jun 26;58(6):1260-71. Epub 2015 Mar 26.

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00125-015-3563-2
Publisher Site
http://dx.doi.org/10.1007/s00125-015-3563-2DOI Listing
June 2015

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

Biotechniques 2015 May 1;58(5):228-33. Epub 2015 May 1.

ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2144/000114285DOI Listing
May 2015

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes.

EBioMedicine 2015 May 17;2(5):378-85. Epub 2015 Mar 17.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485913PMC
May 2015

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.

Hum Mol Genet 2015 Apr 30;24(8):2274-86. Epub 2014 Dec 30.

ULB Center for Diabetes Research and, Division of Endocrinology, Erasmus Hospital, 1070, Brussels, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu745DOI Listing
April 2015

Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets.

Biochem Biophys Res Commun 2014 Oct 28;453(3):398-404. Epub 2014 Sep 28.

Department of Clinical Sciences, Lund, Medicine, Lund University, SE22184 Lund, Sweden. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X140172
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2014.09.096DOI Listing
October 2014

Optical control of insulin release using a photoswitchable sulfonylurea.

Nat Commun 2014 Oct 14;5:5116. Epub 2014 Oct 14.

Department of Chemistry, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstrasse 5-13, 81377 München, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ncomms6116
Publisher Site
http://dx.doi.org/10.1038/ncomms6116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208094PMC
October 2014

Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.

Diabetologia 2014 Sep 18;57(9):1876-83. Epub 2014 Jun 18.

Department of Clinical Sciences, Biomedical Center, C11, Lund University, SE22184, Lund, Sweden,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-014-3299-4DOI Listing
September 2014

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

ACS Chem Biol 2014 Sep 17;9(9):2111-20. Epub 2014 Jul 17.

Section of Cell Biology, Division of Medicine, and ‡National Heart and Lung Institute, Imperial College London , London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb5004064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101202PMC
September 2014

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.

Diabetes 2014 Jul 7;63(7):2516-27. Epub 2014 Mar 7.

Laboratory of Experimental Medicine, Université Libre de Bruxelles Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db13-1443DOI Listing
July 2014

Incretin-modulated beta cell energetics in intact islets of Langerhans.

Mol Endocrinol 2014 Jun 25;28(6):860-71. Epub 2014 Apr 25.

Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine (D.J.H, A.I.T., S.G.B., R.K.M., N.R.J., S.H., M.C.C., G.A.R.), Imperial College London, London W12 0NN, United Kingdom; Department of Endocrinology and Metabolism (M.B., P.M.), University of Pisa, 56126 Pisa, Italy; Cell Isolation and Transplantation Center, Department of Surgery (D.B.), Geneva University Hospitals and University of Geneva, 1205 Geneva, Switzerland; Oxford Centre for Diabetes, Endocrinology, & Metabolism (P.R.J., S.J.H.), University of Oxford, Oxford OX3 7LE, United Kingdom; NIHR Oxford Biomedical Research Centre (P.R.J., S.J.H.), Churchill Hospital, Oxford OX3 7LE, United Kingdom; and Nuffield Department of Surgical Sciences (P.R.J., S.J.H.), University of Oxford, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2014-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042069PMC
June 2014

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.

Diabetologia 2014 Mar 19;57(3):502-11. Epub 2013 Dec 19.

Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Route de Lennik, 808 - CP618, 1070, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-013-3135-2DOI Listing
March 2014