Publications by authors named "Piero Marchetti"

99Publications

Nanoencapsulated human pancreatic islets for β-cell replacement in Type 1 diabetes.

Nanomedicine (Lond) 2020 08 16;15(18):1735-1738. Epub 2020 Jul 16.

Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.2217/nnm-2020-0166DOI Listing
August 2020

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes.

Diabetes Obes Metab 2020 Jun 1. Epub 2020 Jun 1.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1111/dom.14104DOI Listing
June 2020

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation.

Case Rep Transplant 2020 11;2020:6152035. Epub 2020 May 11.

Department of Clinical and Experimental Medicine, Division of Metabolism and Cell Transplantation, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1155/2020/6152035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238346PMC
May 2020

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes.

Semin Cell Dev Biol 2020 07 13;103:83-93. Epub 2020 May 13.

Department of Clinical and Experimental Medicine - University of Pisa, Via Savi 10, Pisa, Italy.

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http://dx.doi.org/10.1016/j.semcdb.2020.04.005DOI Listing
July 2020

Induction and Immunosuppressive Management of Pancreas Transplant Recipients.

Curr Pharm Des 2020 ;26(28):3425-3439

Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.2174/1381612826666200430111620DOI Listing
January 2020

Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description.

Diabetes Metab Syndr Obes 2020 1;13:963-978. Epub 2020 Apr 1.

Department of Clinical and Experimental Medicine, Division of Metabolism and Cell Transplantation, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.2147/DMSO.S219438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136665PMC
April 2020

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.

Stem Cell Res Ther 2020 01 3;11(1). Epub 2020 Jan 3.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik 808-CP618, 1070, Brussels, Belgium.

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http://dx.doi.org/10.1186/s13287-019-1523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942385PMC
January 2020

A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice.

Diabetologia 2020 04 23;63(4):825-836. Epub 2019 Dec 23.

ULB Center for Diabetes Research and Welbio, Medical Faculty, Université Libre de Bruxelles (ULB), Route de Lennik 808-CP618, 1070, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00125-019-05068-5DOI Listing
April 2020

The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells.

J Mol Endocrinol 2019 Aug;63(2):139-149

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1530/JME-19-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938585PMC
August 2019

Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets.

Cell Metab 2019 06 14;29(6):1422-1432.e3. Epub 2019 Mar 14.

Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.02.012DOI Listing
June 2019

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells.

J Innate Immun 2019 20;11(4):375-390. Epub 2019 Feb 20.

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium,

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http://dx.doi.org/10.1159/000496034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738210PMC
July 2020

A Call for Improved Reporting of Human Islet Characteristics in Research Articles.

Diabetes 2019 02 14;68(2):239-240. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, U.K.

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http://dx.doi.org/10.2337/dbi18-0055DOI Listing
February 2019

A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2019 02 14;62(2):209-211. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00125-018-4784-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259467PMC
February 2019

Probing the light scattering properties of insulin secretory granules in single live cells.

Biochem Biophys Res Commun 2018 09 14;503(4):2710-2714. Epub 2018 Aug 14.

NEST - Scuola Normale Superiore, Istituto Nanoscienze - CNR (CNR NANO), Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183170
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http://dx.doi.org/10.1016/j.bbrc.2018.08.029DOI Listing
September 2018

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Cell Metab 2018 12 2;28(6):946-960.e6. Epub 2018 Aug 2.

INSERM, U1016, Cochin Institute, 75014 Paris, France; CNRS, UMR8104, Cochin Institute, 75014 Paris, France; Paris Descartes University, Sorbonne Paris Cité, 75014 Paris, France; Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Cochin Hospital, 75014 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.007DOI Listing
December 2018

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Diabetologia 2018 08 12;61(8):1780-1793. Epub 2018 May 12.

Unité Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Équipe Régulation de la glycémie par le système nerveux central, Université Paris Diderot, 4 rue Marie-Andrée-Lagroua-Weill-Hallé, 75205, Paris CEDEX 13, France.

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http://dx.doi.org/10.1007/s00125-018-4629-8DOI Listing
August 2018

MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s.

Int J Mol Sci 2018 Apr 12;19(4). Epub 2018 Apr 12.

Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/ijms19041170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979342PMC
April 2018

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.

Diabetologia 2018 04 21;61(4):770-774. Epub 2018 Jan 21.

Department of Clinical and Experimental Medicine and University Hospital, University of Pisa, via Paradisa 2, 56121, Pisa, Italy.

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http://dx.doi.org/10.1007/s00125-018-4546-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449064PMC
April 2018

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Diabetologia 2018 03 5;61(3):636-640. Epub 2018 Jan 5.

ULB Center for Diabetes Research, Medical Faculty, Campus Erasme, Université Libre de Bruxelles, Route de Lennik, 808-CP618, B-1070, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00125-017-4536-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241216PMC
March 2018

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Diabetes 2018 Mar 28;67(3):385-399. Epub 2017 Dec 28.

Section of Cell Biology and Functional Genomics and Pancreatic Islet Biology and Diabetes Consortium, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db17-0639DOI Listing
March 2018

MiR-184 expression is regulated by AMPK in pancreatic islets.

FASEB J 2018 05 8;32(5):2587-2600. Epub 2018 Jan 8.

Section of Cell Biology and Functional Genomics Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1096/fj.201701100RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207280PMC
May 2018

Duodenal graft complications requiring duodenectomy after pancreas and pancreas-kidney transplantation.

Am J Transplant 2018 06 9;18(6):1388-1396. Epub 2018 Jan 9.

Division of General and Transplant Surgery, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1111/ajt.14613DOI Listing
June 2018

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion.

Diabetes 2017 11 19;66(11):2849-2856. Epub 2017 Jul 19.

Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy

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http://dx.doi.org/10.2337/db17-0002DOI Listing
November 2017

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

Diabetes 2017 09 30;66(9):2446-2458. Epub 2017 Jun 30.

Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium

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http://dx.doi.org/10.2337/db16-1252DOI Listing
September 2017

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes.

Front Cell Dev Biol 2017 23;5:55. Epub 2017 May 23.

Department of Clinical and Experimental Medicine, University of PisaPisa, Italy.

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http://dx.doi.org/10.3389/fcell.2017.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440564PMC
May 2017

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.

Endocrinology 2017 08;158(8):2503-2521

Université Libre de Bruxelles Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1210/en.2017-00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551554PMC
August 2017

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

Biochem Pharmacol 2017 08 15;138:140-149. Epub 2017 May 15.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.05.007DOI Listing
August 2017

Update on pancreatic transplantation on the management of diabetes.

Minerva Med 2017 Oct 2;108(5):405-418. Epub 2017 May 2.

Division of General and Transplant Surgery, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy -

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http://dx.doi.org/10.23736/S0026-4806.17.05224-7DOI Listing
October 2017

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.

Endocrinology 2017 06;158(6):1659-1670

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1210/en.2016-1773DOI Listing
June 2017

Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus.

Diabetes Metab Res Rev 2017 09 18;33(6). Epub 2017 Apr 18.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

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http://doi.wiley.com/10.1002/dmrr.2894
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http://dx.doi.org/10.1002/dmrr.2894DOI Listing
September 2017

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

Diabetologia 2017 04 6;60(4):656-667. Epub 2017 Jan 6.

ULB Center for Diabetes Research, Campus Erasme, Université Libre de Bruxelles, Route de Lennik, 808-CP618, B-1070, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00125-016-4201-3DOI Listing
April 2017

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cell Death Differ 2016 12 2;23(12):1995-2006. Epub 2016 Sep 2.

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1038/cdd.2016.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136495PMC
December 2016

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Cell Metab 2016 09 21;24(3):389-401. Epub 2016 Jul 21.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, UK; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031557PMC
September 2016

Islet inflammation in type 2 diabetes.

Authors:
Piero Marchetti

Diabetologia 2016 Apr 19;59(4):668-72. Epub 2016 Feb 19.

Department of Clinical and Experimental Medicine, Cisanello University Hospital, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

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http://link.springer.com/10.1007/s00125-016-3875-x
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http://dx.doi.org/10.1007/s00125-016-3875-xDOI Listing
April 2016

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Diabetes 2016 04 28;65(4):1009-21. Epub 2016 Jan 28.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db15-1334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806657PMC
April 2016

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes.

J Clin Endocrinol Metab 2016 Mar 29;101(3):1044-54. Epub 2015 Dec 29.

Departments of Medicine (F.C., R.B., J.Y.K.-M., D.A.) and Surgery (Y.O., P.R.S., L.E.R.), Columbia University College of Physicians and Surgeons, New York, New York 10032; Department of Clinical and Experimental Medicine (F.C.), Università Politecnica delle Marche, Ancona, Italy; and Department of Clinical and Experimental Medicine (M.M., L.M., M.S., P.M.), Islet Cell Laboratory, University of Pisa, 56100 Pisa, Italy.

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http://dx.doi.org/10.1210/jc.2015-2860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803182PMC
March 2016

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

Diabetologia 2015 Nov 15;58(11):2554-62. Epub 2015 Aug 15.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s00125-015-3734-1DOI Listing
November 2015

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.

Diabetes 2015 Nov 3;64(11):3808-17. Epub 2015 Aug 3.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.2337/db15-0362DOI Listing
November 2015

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes.

EBioMedicine 2015 May 17;2(5):378-85. Epub 2015 Mar 17.

ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ebiom.2015.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485913PMC
May 2015

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Diabetologia 2015 Oct 23;58(10):2307-16. Epub 2015 Jun 23.

ULB-Center for Diabetes Research, Universitè Libre de Bruxelles (ULB), Route de Lennik, 808-CP618, 1070, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00125-015-3669-6DOI Listing
October 2015